```json
{"claims": [
  {"claim": "Loeys-Dietz syndrome is caused by heterozygous variants in genes of the TGF-beta signalling pathway.",
   "quote": "Loeys-Dietz syndrome is caused by heterozygous variants in genes of the TGF-beta\nsignalling pathway",
   "subject": "Loeys-Dietz syndrome",
   "predicate": "is caused by",
   "object": "heterozygous variants in genes of the TGF-beta signalling pathway",
   "negated": false,
   "qualifier": null,
   "subject_qualifier": null,
   "object_qualifier": null,
   "entities": ["Loeys-Dietz syndrome", "TGF-beta signalling pathway"],
   "citations": ["[1]"],
   "about": "domain",
   "basis": "secondary_source"},

  {"claim": "Loeys-Dietz syndrome is most often caused by variants in TGFBR1 or TGFBR2.",
   "quote": "most often TGFBR1 or TGFBR2",
   "subject": "Loeys-Dietz syndrome",
   "predicate": "is most often caused by variants in",
   "object": "TGFBR1 or TGFBR2",
   "negated": false,
   "qualifier": "most often",
   "subject_qualifier": null,
   "object_qualifier": null,
   "entities": ["Loeys-Dietz syndrome", "TGFBR1", "TGFBR2"],
   "citations": ["[1]"],
   "about": "domain",
   "basis": "secondary_source"},

  {"claim": "Loeys et al. described Loeys-Dietz syndrome in 2005.",
   "quote": "Loeys et al. described it\nin 2005 in families with arterial tortuosity and aortic aneurysms",
   "subject": "Loeys et al.",
   "predicate": "described in",
   "object": "2005",
   "negated": false,
   "qualifier": null,
   "subject_qualifier": null,
   "object_qualifier": null,
   "entities": ["Loeys et al.", "Loeys-Dietz syndrome"],
   "citations": ["[1]"],
   "about": "work",
   "basis": null},

  {"claim": "Loeys et al. described Loeys-Dietz syndrome in families with arterial tortuosity and aortic aneurysms.",
   "quote": "Loeys et al. described it\nin 2005 in families with arterial tortuosity and aortic aneurysms",
   "subject": "Loeys et al.",
   "predicate": "described Loeys-Dietz syndrome in",
   "object": "families with arterial tortuosity and aortic aneurysms",
   "negated": false,
   "qualifier": null,
   "subject_qualifier": null,
   "object_qualifier": null,
   "entities": ["Loeys et al.", "Loeys-Dietz syndrome", "arterial tortuosity", "aortic aneurysms"],
   "citations": ["[1]"],
   "about": "work",
   "basis": null},

  {"claim": "Variants in SMAD3 were later found to cause the same phenotype as Loeys-Dietz syndrome caused by TGFBR1/TGFBR2 variants.",
   "quote": "Variants in\nSMAD3 and TGFB2 were later found to cause the same phenotype",
   "subject": "Variants in SMAD3",
   "predicate": "were later found to cause",
   "object": "the same phenotype as Loeys-Dietz syndrome",
   "negated": false,
   "qualifier": "later found",
   "subject_qualifier": null,
   "object_qualifier": null,
   "entities": ["SMAD3", "Loeys-Dietz syndrome"],
   "citations": ["[3]"],
   "about": "domain",
   "basis": "secondary_source"},

  {"claim": "Variants in TGFB2 were later found to cause the same phenotype as Loeys-Dietz syndrome caused by TGFBR1/TGFBR2 variants.",
   "quote": "Variants in\nSMAD3 and TGFB2 were later found to cause the same phenotype",
   "subject": "Variants in TGFB2",
   "predicate": "were later found to cause",
   "object": "the same phenotype as Loeys-Dietz syndrome",
   "negated": false,
   "qualifier": "later found",
   "subject_qualifier": null,
   "object_qualifier": null,
   "entities": ["TGFB2", "Loeys-Dietz syndrome"],
   "citations": ["[3]"],
   "about": "domain",
   "basis": "secondary_source"}
]}
```