```json
{
  "claims": [
    {
      "claim": "Loeys-Dietz syndrome is caused by heterozygous variants in genes of the TGF-beta signalling pathway.",
      "quote": "Loeys-Dietz syndrome is caused by heterozygous variants in genes of the TGF-beta signalling pathway",
      "subject": "Loeys-Dietz syndrome",
      "predicate": "is caused by",
      "object": "heterozygous variants in genes of the TGF-beta signalling pathway",
      "negated": false,
      "qualifier": null,
      "subject_qualifier": null,
      "object_qualifier": null,
      "entities": ["Loeys-Dietz syndrome", "TGF-beta signalling pathway"],
      "citations": ["[1]"],
      "about": "domain",
      "basis": "secondary_source"
    },
    {
      "claim": "Loeys-Dietz syndrome is most often caused by heterozygous variants in TGFBR1.",
      "quote": "most often TGFBR1",
      "subject": "Loeys-Dietz syndrome",
      "predicate": "is most often caused by heterozygous variants in",
      "object": "TGFBR1",
      "negated": false,
      "qualifier": "most often",
      "subject_qualifier": null,
      "object_qualifier": null,
      "entities": ["Loeys-Dietz syndrome", "TGFBR1"],
      "citations": ["[1]"],
      "about": "domain",
      "basis": "secondary_source"
    },
    {
      "claim": "Loeys-Dietz syndrome is most often caused by heterozygous variants in TGFBR2.",
      "quote": "most often TGFBR1 or TGFBR2",
      "subject": "Loeys-Dietz syndrome",
      "predicate": "is most often caused by heterozygous variants in",
      "object": "TGFBR2",
      "negated": false,
      "qualifier": "most often",
      "subject_qualifier": null,
      "object_qualifier": null,
      "entities": ["Loeys-Dietz syndrome", "TGFBR2"],
      "citations": ["[1]"],
      "about": "domain",
      "basis": "secondary_source"
    },
    {
      "claim": "Loeys et al. described Loeys-Dietz syndrome in 2005.",
      "quote": "Loeys et al. described it in 2005",
      "subject": "Loeys et al.",
      "predicate": "described",
      "object": "Loeys-Dietz syndrome",
      "negated": false,
      "qualifier": "in 2005",
      "subject_qualifier": null,
      "object_qualifier": null,
      "entities": ["Loeys et al.", "Loeys-Dietz syndrome"],
      "citations": ["[1]"],
      "about": "work",
      "basis": null
    },
    {
      "claim": "Loeys-Dietz syndrome occurs in families with arterial tortuosity and aortic aneurysms.",
      "quote": "in families with arterial tortuosity and aortic aneurysms",
      "subject": "Loeys-Dietz syndrome",
      "predicate": "occurs in families with",
      "object": "arterial tortuosity and aortic aneurysms",
      "negated": false,
      "qualifier": null,
      "subject_qualifier": null,
      "object_qualifier": null,
      "entities": ["Loeys-Dietz syndrome", "arterial tortuosity", "aortic aneurysms"],
      "citations": ["[1]"],
      "about": "domain",
      "basis": "secondary_source"
    },
    {
      "claim": "Variants in SMAD3 cause Loeys-Dietz syndrome phenotype.",
      "quote": "Variants in SMAD3 and TGFB2 were later found to cause the same phenotype",
      "subject": "Variants in SMAD3",
      "predicate": "cause",
      "object": "Loeys-Dietz syndrome phenotype",
      "negated": false,
      "qualifier": "later found",
      "subject_qualifier": null,
      "object_qualifier": null,
      "entities": ["SMAD3", "Loeys-Dietz syndrome"],
      "citations": ["[3]"],
      "about": "domain",
      "basis": "secondary_source"
    },
    {
      "claim": "Variants in TGFB2 cause Loeys-Dietz syndrome phenotype.",
      "quote": "Variants in SMAD3 and TGFB2 were later found to cause the same phenotype",
      "subject": "Variants in TGFB2",
      "predicate": "cause",
      "object": "Loeys-Dietz syndrome phenotype",
      "negated": false,
      "qualifier": "later found",
      "subject_qualifier": null,
      "object_qualifier": null,
      "entities": ["TGFB2", "Loeys-Dietz syndrome"],
      "citations": ["[3]"],
      "about": "domain",
      "basis": "secondary_source"
    }
  ]
}
```