// Created by libAntimony v2.13.0
function Function_for_a_constant_rate_of_influx_of_T_cells_generated_through_the_primary_organs(alpha)
  alpha;
end

Function_for_a_constant_rate_of_influx_of_T_cells_generated_through_the_primary_organs is "Function for a constant rate of influx of T cells generated through the primary organs"

function Function_for_elimination_of_effects_of_the_tumor_immune_interaction_on_the_cancer_volume(gamma_, x, y)
  gamma_*x*y;
end

Function_for_elimination_of_effects_of_the_tumor_immune_interaction_on_the_cancer_volume is "Function for elimination of effects of the tumor immune interaction on the cancer volume"

function Function_for_increase_in_tumor_volume(mu_C, x, x_inf, v)
  mu_C*x*(1 - (x/x_inf)^v);
end

Function_for_increase_in_tumor_volume is "Function for increase in tumor volume"

function Function_for_natural_death_of_T_cells(delta, y)
  delta*y;
end

Function_for_natural_death_of_T_cells is "Function for natural death of T cells"

function Function_for_tumor_immune_interaction_on_the_immune_system(mu_I, beta, x, y)
  mu_I*(1 - beta*x)*x*y;
end

Function_for_tumor_immune_interaction_on_the_immune_system is "Function for tumor immune interaction on the immune system"


model *Ledzewicz2013___On_optimal_chemotherapy_with_a_strongly_targeted_agent_for_a_model_of_tumor_immune_system_interactions_with_generalized_logistic_growth()

  // Compartments and Species:
  compartment compartment_;
  species y in compartment_, x in compartment_;

  // Reactions:
  a_constant_rate_of_influx_of_T_cells_generated_through_the_primary_organs:  => y; compartment_*Function_for_a_constant_rate_of_influx_of_T_cells_generated_through_the_primary_organs(alpha);
  Natural_death_of_T_cells: y => ; compartment_*Function_for_natural_death_of_T_cells(delta, y);
  Tumor_immune_interaction_on_the_immune_system:  => y; compartment_*Function_for_tumor_immune_interaction_on_the_immune_system(mu_I, beta, x, y);
  Elimination_effect_of_the_tumor_immune_interaction_on_the_cancer_volume: x => ; compartment_*Function_for_elimination_of_effects_of_the_tumor_immune_interaction_on_the_cancer_volume(gamma_, x, y);
  Increase_in_tumor_volume:  => x; compartment_*Function_for_increase_in_tumor_volume(mu_C, x, x_inf, v);

  // Species initializations:
  y = 0.1;
  x = 600;

  // Compartment initializations:
  compartment_ = 1;

  // Variable initializations:
  alpha = 0.1181;
  beta = 0.00264;
  gamma_ = 1;
  delta = 0.37451;
  mu_C = 0.5599;
  mu_I = 0.00484;
  x_inf = 780;
  kappa = 1;
  v = 1;

  // Other declarations:
  const compartment_, alpha, beta, gamma_, delta, mu_C, mu_I, x_inf, kappa;
  const v;

  // Unit definitions:
  unit volume = 1e-3 litre;
  unit substance = 1e-3 mole;

  // Display Names:
  compartment_ is "compartment";
  gamma_ is "gamma";
  a_constant_rate_of_influx_of_T_cells_generated_through_the_primary_organs is "a constant rate of influx of T cells generated through the primary organs";
  Natural_death_of_T_cells is "Natural death of T cells";
  Tumor_immune_interaction_on_the_immune_system is "Tumor immune interaction on the immune system";
  Elimination_effect_of_the_tumor_immune_interaction_on_the_cancer_volume is "Elimination effect of the tumor immune interaction on the cancer volume";
  Increase_in_tumor_volume is "Increase in tumor volume";

  // CV terms:
  x class "http://identifiers.org/ncit/C94515"
  a_constant_rate_of_influx_of_T_cells_generated_through_the_primary_organs class "http://identifiers.org/go/GO:0045066"
  Natural_death_of_T_cells hypernym "http://identifiers.org/go/GO:0006924"
  Tumor_immune_interaction_on_the_immune_system class "http://identifiers.org/go/"
  Elimination_effect_of_the_tumor_immune_interaction_on_the_cancer_volume class "http://identifiers.org/go/GO:0002418"
  Increase_in_tumor_volume class "http://identifiers.org/go/GO:0002413"
end

Ledzewicz2013___On_optimal_chemotherapy_with_a_strongly_targeted_agent_for_a_model_of_tumor_immune_system_interactions_with_generalized_logistic_growth is "Ledzewicz2013 - On optimal chemotherapy with a strongly targeted agent for a model of tumor immune system interactions with generalized logistic growth"

Ledzewicz2013___On_optimal_chemotherapy_with_a_strongly_targeted_agent_for_a_model_of_tumor_immune_system_interactions_with_generalized_logistic_growth class "http://identifiers.org/mamo/MAMO_0000046",
                                                                                                                                                              "http://identifiers.org/taxonomy/9606",
                                                                                                                                                              "http://identifiers.org/ncit/"
Ledzewicz2013___On_optimal_chemotherapy_with_a_strongly_targeted_agent_for_a_model_of_tumor_immune_system_interactions_with_generalized_logistic_growth description "http://identifiers.org/ncit/",
                                                                                                                                                                    "http://identifiers.org/pubmed/23906150"
Ledzewicz2013___On_optimal_chemotherapy_with_a_strongly_targeted_agent_for_a_model_of_tumor_immune_system_interactions_with_generalized_logistic_growth model_entity_is "http://identifiers.org/biomodels.db/MODEL2003060003",
                                                                                                                                                                        "http://identifiers.org/biomodels.db/BIOMD0000000919"
Ledzewicz2013___On_optimal_chemotherapy_with_a_strongly_targeted_agent_for_a_model_of_tumor_immune_system_interactions_with_generalized_logistic_growth taxon "http://identifiers.org/taxonomy/9606"
Ledzewicz2013___On_optimal_chemotherapy_with_a_strongly_targeted_agent_for_a_model_of_tumor_immune_system_interactions_with_generalized_logistic_growth property "http://identifiers.org/mamo/MAMO_0000046"
