// Created by libAntimony v2.13.0
function Function_for_removal_of_stem_cell_from_the_system(gamma1, I, C)
  gamma1*I*C;
end

Function_for_removal_of_stem_cell_from_the_system is "Function for removal of stem cell from the system"

function Function_for_formation_of_Stem_cell(k1, C, M1, p1, E, a1)
  k1*C*(1 - C/M1) + p1*C*E/(a1 + C);
end

Function_for_formation_of_Stem_cell is "Function for formation of Stem cell"

function Function_for_increase_in_healthy_cell_in_the_system(q, H, M3)
  q*H*(1 - H/M3);
end

Function_for_increase_in_healthy_cell_in_the_system is "Function for increase in healthy cell in the system"

function Function_for_decrease_in_healthy_cell(delta, H, T, p3, E, a3)
  delta*H*T + p3*H*E/(a3 + H);
end

Function_for_decrease_in_healthy_cell is "Function for decrease in healthy cell"

function Function_for_induction_of_tumor_cell(k2, C, M1, T, M2, p2, E, a2)
  k2*C*(C/M1)*(1 - T/M2) + p2*T*E/(a2 + T);
end

Function_for_induction_of_tumor_cell is "Function for induction of tumor cell"

function Function_for_removal_of_tumor_cell(n1, T, gamma2, I)
  n1*T + gamma2*I*T;
end

Function_for_removal_of_tumor_cell is "Function for removal of tumor cell"

function Function_for_increase_in_excess_strogen(tau)
  tau;
end

Function_for_increase_in_excess_strogen is "Function for increase in excess strogen"

function Function_for_decrease_in_strogen_content(mu, d1, C, a1, d2, T, a2, d3, H, a3, E)
  (mu + d1*C/(a1 + C) + d2*T/(a2 + T) + d3*H/(a3 + H))*E;
end

Function_for_decrease_in_strogen_content is "Function for decrease in strogen content"

function Function_for_increase_in_tumor_cell_against_cancer(s, p, I, T, w)
  s + p*I*T/(w + T);
end

Function_for_increase_in_tumor_cell_against_cancer is "Function for increase in tumor cell against cancer"

function Function_for_decrease_in_immune_cell(gamma3, I, T, n2, u, E, v)
  gamma3*I*T + n2*I + u*I*E/(v + E);
end

Function_for_decrease_in_immune_cell is "Function for decrease in immune cell"


model *Solis_perez2019___A_fractional_mathematical_model_of_breast_cancer_competition_model()

  // Compartments and Species:
  compartment compartment_;
  species C in compartment_, T in compartment_, H in compartment_, I in compartment_;
  species E in compartment_;

  // Reactions:
  Formation_of_Stem_cell:  => C; compartment_*Function_for_formation_of_Stem_cell(k1, C, M1, p1, E, a1);
  Removal_of_stem_cell_from_the_system: C => ; compartment_*Function_for_removal_of_stem_cell_from_the_system(gamma1, I, C);
  Induction_of_tumor_cell:  => T; compartment_*Function_for_induction_of_tumor_cell(k2, C, M1, T, M2, p2, E, a2);
  Removal_of_tumor_cell_y_immune_cell_and_other_immune_response: T => ; compartment_*Function_for_removal_of_tumor_cell(n1, T, gamma2, I);
  Increase_in_the_healthy_cell_in_the_system:  => H; compartment_*Function_for_increase_in_healthy_cell_in_the_system(q, H, M3);
  Decrase_of_healthy_cell_due_to_cancer: H => ; compartment_*Function_for_decrease_in_healthy_cell(delta, H, T, p3, E, a3);
  Increase_in_immune_cell_against_tumor:  => I; compartment_*Function_for_increase_in_tumor_cell_against_cancer(s, p, I, T, w);
  Decrease_in_the_density_of_immune_cell_that_provide_immune_response: I => ; compartment_*Function_for_decrease_in_immune_cell(gamma3, I, T, n2, u, E, v);
  Increase_in_Excess_strogen:  => E; compartment_*Function_for_increase_in_excess_strogen(tau);
  Decrease_in_strogen_content: E => ; compartment_*Function_for_decrease_in_strogen_content(mu, d1, C, a1, d2, T, a2, d3, H, a3, E);

  // Species initializations:
  C = 737100;
  T = 7616700;
  H = 25000000;
  I = 0;
  E = 0;

  // Compartment initializations:
  compartment_ = 1;

  // Variable initializations:
  k1 = 0.75;
  k2 = 0.514;
  q = 0.7;
  M1 = 2270000;
  M2 = 22700000;
  M3 = 25000000;
  gamma1 = 3e-07;
  gamma2 = 3e-06;
  gamma3 = 1e-07;
  p1 = 600;
  p2 = 0;
  p3 = 100;
  a1 = 1135000;
  a2 = 11350000;
  a3 = 1250000;
  n1 = 0.01;
  n2 = 0.29;
  delta = 6e-08;
  s = 13000;
  p = 0.2;
  w = 300000;
  u = 0.2;
  v = 400;
  tau = 2700;
  d1 = 0.01;
  d2 = 0.01;
  d3 = 0.01;
  mu = 0.97;

  // Other declarations:
  const compartment_, k1, k2, q, M1, M2, M3, gamma1, gamma2, gamma3, p1, p2;
  const p3, a1, a2, a3, n1, n2, delta, s, p, w, u, v, tau, d1, d2, d3, mu;

  // Unit definitions:
  unit volume = 1e-3 litre;
  unit time_unit = 86400 second;
  unit substance = 1e-3 mole;

  // Display Names:
  time_unit is "time";
  compartment_ is "compartment";
  Formation_of_Stem_cell is "Formation of Stem cell";
  Removal_of_stem_cell_from_the_system is "Removal of stem cell from the system";
  Induction_of_tumor_cell is "Induction of tumor cell";
  Removal_of_tumor_cell_y_immune_cell_and_other_immune_response is "Removal of tumor cell y immune cell and other immune response";
  Increase_in_the_healthy_cell_in_the_system is "Increase in the healthy cell in the system";
  Decrase_of_healthy_cell_due_to_cancer is "Decrase of healthy cell due to cancer";
  Increase_in_immune_cell_against_tumor is "Increase in immune cell against tumor";
  Decrease_in_the_density_of_immune_cell_that_provide_immune_response is "Decrease in the density of immune cell that provide immune response";
  Increase_in_Excess_strogen is "Increase in Excess strogen";
  Decrease_in_strogen_content is "Decrease in strogen content";

  // CV terms:
  C instance "http://identifiers.org/bto/BTO:0006293"
  T instance "http://identifiers.org/ncit/C12922"
  H property "http://identifiers.org/ncit/C115935"
  I instance "http://identifiers.org/ncit/C132890"
  Formation_of_Stem_cell instance "http://identifiers.org/ncit/C25513"
  Removal_of_stem_cell_from_the_system instance "http://identifiers.org/ncit/C64914"
  Induction_of_tumor_cell instance "http://identifiers.org/ncit/C25533"
  Removal_of_tumor_cell_y_immune_cell_and_other_immune_response instance "http://identifiers.org/ncit/"
  Increase_in_the_healthy_cell_in_the_system instance "http://identifiers.org/ncit/C25533"
  Decrase_of_healthy_cell_due_to_cancer instance "http://identifiers.org/ncit/C25640"
  Increase_in_immune_cell_against_tumor instance "http://identifiers.org/ncit/C25533"
  Decrease_in_the_density_of_immune_cell_that_provide_immune_response instance "http://identifiers.org/ncit/C25640"
  Increase_in_Excess_strogen instance "http://identifiers.org/ncit/C25533"
  Decrease_in_strogen_content instance "http://identifiers.org/ncit/C25640"
end

Solis_perez2019___A_fractional_mathematical_model_of_breast_cancer_competition_model is "Solis-perez2019 - A fractional mathematical model of breast cancer competition model"

Solis_perez2019___A_fractional_mathematical_model_of_breast_cancer_competition_model instance "http://identifiers.org/mamo/MAMO_0000046",
                                                                                              "http://identifiers.org/taxonomy/9606",
                                                                                              "http://identifiers.org/ncit/C4872"
Solis_perez2019___A_fractional_mathematical_model_of_breast_cancer_competition_model description "http://identifiers.org/ncit/C4872",
                                                                                                 "http://identifiers.org/doi/10.1016/j.chaos.2019.06.027"
Solis_perez2019___A_fractional_mathematical_model_of_breast_cancer_competition_model origin "http://identifiers.org/doi/10.1007/s12591-017-0346-x"
Solis_perez2019___A_fractional_mathematical_model_of_breast_cancer_competition_model model_entity_is "http://identifiers.org/biomodels.db/MODEL1912180005",
                                                                                                     "http://identifiers.org/biomodels.db/BIOMD0000000903"
Solis_perez2019___A_fractional_mathematical_model_of_breast_cancer_competition_model property "http://identifiers.org/mamo/MAMO_0000046"
Solis_perez2019___A_fractional_mathematical_model_of_breast_cancer_competition_model taxon "http://identifiers.org/taxonomy/9606"
