// Created by libAntimony v2.13.0
function Function_for_Vicodin_Use_Transition_Abuse_Relapse_Nonlinear(gamma_3, A, T)
  gamma_3*A*T;
end

Function_for_Vicodin_Use_Transition_Abuse_Relapse_Nonlinear is "Function_for_Vicodin_Use_Transition_Abuse_Relapse_Nonlinear"

function Function_for_New_Vicodin_Prescriptions(lambda, rho, A)
  lambda/(1 + rho*A);
end

Function_for_New_Vicodin_Prescriptions is "Function_for_New_Vicodin_Prescriptions"


model *Caldwell2019___The_Vicodin_abuse_problem()

  // Compartments and Species:
  compartment compartment_;
  species M in compartment_, C1 in compartment_, C2 in compartment_, A in compartment_;
  species T in compartment_;

  // Reactions:
  New_Vicodin_Prescriptions:  => M; compartment_*Function_for_New_Vicodin_Prescriptions(lambda, rho, A);
  Vicodin_Use_Transition_Acute_Chronic: M => C1; compartment_*alpha_1*M;
  Vicodin_Use_Transition_Cessation: M => ; compartment_*alpha_2*M;
  Vicodin_Use_Transition_Chronic_Abuse: C2 => A; compartment_*delta*C2;
  Vicodin_Use_Transition_Chronic_Exit: C1 => ; compartment_*beta*C1;
  Vicodin_Use_Transition_Chronic: C1 => C2; compartment_*delta*C1;
  Vicodin_Use_Transition_Chronic2_Exit: C2 => ; compartment_*beta*C2;
  Vicodin_Use_Transition_Abuse_Treatment_Exit: A => T; compartment_*epsilon*A;
  Vicodin_Use_Transition_Abuse_Relapse_Linear: T => A; compartment_*gamma_1*T;
  Vicodin_Use_Transition_Abuse_Relapse_Nonlinear: T => A; compartment_*Function_for_Vicodin_Use_Transition_Abuse_Relapse_Nonlinear(gamma_3, A, T);
  Vicodin_Use_Transition_Treatment_Succesful: T => ; compartment_*gamma_2*T;

  // Species initializations:
  M = 37600000;
  C1 = 5640000;
  C2 = 3760000;
  A = 2000000;
  T = 700000;

  // Compartment initializations:
  compartment_ = 1;

  // Variable initializations:
  lambda = 3000000;
  rho = 1e-06;
  alpha_1 = 0.22;
  alpha_2 = 0.45;
  beta = 0.14;
  delta = 0.05;
  epsilon = 0.03;
  gamma_1 = 0.24;
  gamma_2 = 0.293;
  gamma_3 = 8e-10;

  // Other declarations:
  const compartment_, lambda, rho, alpha_1, alpha_2, beta, delta, epsilon;
  const gamma_1, gamma_2, gamma_3;

  // Unit definitions:
  unit volume = 1e-3 litre;
  unit time_unit = 86400 second;
  unit substance = item;

  // Display Names:
  time_unit is "time";
  compartment_ is "compartment";

  // CV terms:
  compartment_ hypernym "http://identifiers.org/ncit/C17005"
  M property "http://identifiers.org/ncit/C14140"
  C1 property "http://identifiers.org/ncit/C14141"
  C2 property "http://identifiers.org/ncit/C14141"
  A property "http://identifiers.org/ncit/C16522"
  T property "http://identifiers.org/efo/0000727"
  New_Vicodin_Prescriptions identity "http://identifiers.org/ncit/C28180"
  Vicodin_Use_Transition_Acute_Chronic property "http://identifiers.org/ncit/C14141"
  Vicodin_Use_Transition_Cessation property "http://identifiers.org/ncit/C61497"
  Vicodin_Use_Transition_Chronic_Abuse property "http://identifiers.org/ncit/C16522"
  Vicodin_Use_Transition_Chronic_Exit property "http://identifiers.org/ncit/C61497"
  Vicodin_Use_Transition_Chronic property "http://identifiers.org/ncit/C14141"
  Vicodin_Use_Transition_Chronic2_Exit property "http://identifiers.org/ncit/C61497"
  Vicodin_Use_Transition_Abuse_Treatment_Exit property "http://identifiers.org/ncit/C3479"
  Vicodin_Use_Transition_Abuse_Treatment_Exit property "http://identifiers.org/ncit/C61497"
  Vicodin_Use_Transition_Abuse_Treatment_Exit property "http://identifiers.org/ncit/C70742"
  Vicodin_Use_Transition_Abuse_Relapse_Linear hypernym "http://identifiers.org/efo/0004952"
  Vicodin_Use_Transition_Abuse_Relapse_Nonlinear hypernym "http://identifiers.org/efo/0004952"
  Vicodin_Use_Transition_Treatment_Succesful property "http://identifiers.org/ncit/C25362"
  Vicodin_Use_Transition_Treatment_Succesful property "http://identifiers.org/efo/0000727"
end

Caldwell2019___The_Vicodin_abuse_problem is "Caldwell2019 - The Vicodin abuse problem"

Caldwell2019___The_Vicodin_abuse_problem description "http://identifiers.org/pubmed/31513802"
Caldwell2019___The_Vicodin_abuse_problem model_entity_is "http://identifiers.org/biomodels.db/MODEL1910290002",
                                                         "http://identifiers.org/biomodels.db/BIOMD0000000840"
Caldwell2019___The_Vicodin_abuse_problem property "http://identifiers.org/ncit/C16522"
Caldwell2019___The_Vicodin_abuse_problem property "http://identifiers.org/mamo/MAMO_0000046"
Caldwell2019___The_Vicodin_abuse_problem property "http://identifiers.org/chebi/CHEBI:5779"
