// Created by libAntimony v2.13.0
function Constant_flux__irreversible(v)
  v;
end

Constant_flux__irreversible is "Constant flux (irreversible)"

function Function_for_Malignant_Cells_Growth(alpha, x)
  alpha*x;
end

Function_for_Malignant_Cells_Growth is "Function_for_Malignant_Cells_Growth"

function Function_for_Lymphocyte_Elimination_1(y, alpha)
  y/alpha;
end

Function_for_Lymphocyte_Elimination_1 is "Function_for_Lymphocyte_Elimination_1"

function Function_for_Lymphocyte_Elimination_Malignant_Cells(k, x)
  k*x;
end

Function_for_Lymphocyte_Elimination_Malignant_Cells is "Function_for_Lymphocyte_Elimination_Malignant_Cells"

function Function_for_Malignant_Cells_Death_Lymphocytes(x, y)
  x*y;
end

Function_for_Malignant_Cells_Death_Lymphocytes is "Function_for_Malignant_Cells_Death_Lymphocytes"


model *Sotolongo_Costa2003___Behavior_of_tumors_under_nonstationary_therapy()

  // Compartments and Species:
  compartment compartment_;
  species x_Malignant_Cells in compartment_, y_Lymphocytes in compartment_;

  // Reactions:
  Malignant_Cells_Growth:  => x_Malignant_Cells; compartment_*Function_for_Malignant_Cells_Growth(alpha, x_Malignant_Cells);
  Malignant_Cells_Death_Lymphocytes: x_Malignant_Cells => y_Lymphocytes; compartment_*Function_for_Malignant_Cells_Death_Lymphocytes(x_Malignant_Cells, y_Lymphocytes);
  Lymphocytes_Production:  => y_Lymphocytes; compartment_*Constant_flux__irreversible(sigma);
  Lymphocyte_Death: y_Lymphocytes => ; compartment_*Function_for_Lymphocyte_Elimination_1(y_Lymphocytes, alpha);
  Lymphocyte_Elimination_Malignant_Cells: y_Lymphocytes => ; compartment_*Function_for_Lymphocyte_Elimination_Malignant_Cells(k, x_Malignant_Cells);

  // Species initializations:
  x_Malignant_Cells = 5.3;
  y_Lymphocytes = 6.7;

  // Compartment initializations:
  compartment_ = 1;

  // Variable initializations:
  alpha = 2;
  k = 0.2;
  sigma = 0.25;

  // Other declarations:
  const compartment_, alpha, k, sigma;

  // Unit definitions:
  unit volume = 1e-3 litre;
  unit substance = 1e-3 mole;

  // Display Names:
  compartment_ is "compartment";

  // CV terms:
  compartment_ hypernym "http://identifiers.org/ncit/C94498"
  x_Malignant_Cells hypernym "http://identifiers.org/cl/CL:0001063"
  y_Lymphocytes identity "http://identifiers.org/cl/CL:0000542"
  Malignant_Cells_Growth hypernym "http://identifiers.org/ncit/C18081"
  Malignant_Cells_Death_Lymphocytes hypernym "http://identifiers.org/go/GO:0001906"
  Lymphocytes_Production hypernym "http://identifiers.org/ncit/C18081"
  Lymphocyte_Death hypernym "http://identifiers.org/go/GO:0008219"
  Lymphocyte_Elimination_Malignant_Cells hypernym "http://identifiers.org/go/cell death"
end

Sotolongo_Costa2003___Behavior_of_tumors_under_nonstationary_therapy is "Sotolongo-Costa2003 - Behavior of tumors under nonstationary therapy"

Sotolongo_Costa2003___Behavior_of_tumors_under_nonstationary_therapy description "http://identifiers.org/doi/10.1016/S0167-2789(03)00005-8"
Sotolongo_Costa2003___Behavior_of_tumors_under_nonstationary_therapy model_entity_is "http://identifiers.org/biomodels.db/MODEL1908090002",
                                                                                     "http://identifiers.org/biomodels.db/BIOMD0000000785"
Sotolongo_Costa2003___Behavior_of_tumors_under_nonstationary_therapy property "http://identifiers.org/mamo/MAMO_0000046"
Sotolongo_Costa2003___Behavior_of_tumors_under_nonstationary_therapy property "http://identifiers.org/go/GO:0002424"
