// Created by libAntimony v2.13.0
function Function_for_Length_of_Eclipse_Phase(b, n, tau, x, y)
  b*exp(-n*tau)*x*y;
end

Function_for_Length_of_Eclipse_Phase is "Function_for_Length_of_Eclipse_Phase"

function Function_for_Stimulation(c, y, z)
  c*y*z;
end

Function_for_Stimulation is "Function_for_Stimulation"

function Function_for_Immune_Kill(p, y, z)
  p*y*z;
end

Function_for_Immune_Kill is "Function_for_Immune_Kill"

function Function_for_Uninfected_Cells_Proliferation(r, x, y, k)
  r*x*(1 - (x + y)/k);
end

Function_for_Uninfected_Cells_Proliferation is "Function_for_Uninfected_Cells_Proliferation"


model *Wang2019_-_A_mathematical_model_of_oncolytic_virotherapy_with_time_delay()

  // Compartments and Species:
  compartment compartment_;
  species x in compartment_, I in compartment_, y in compartment_, z in compartment_;

  // Reactions:
  Uninfected_Cells_Proliferation:  => x; compartment_*Function_for_Uninfected_Cells_Proliferation(r, x, y, k);
  Uninfected_Cells_Infection: x + y => I; compartment_*b*x*y;
  Length_of_Eclipse_Phase: I => y; compartment_*Function_for_Length_of_Eclipse_Phase(b, n, tau, x, y);
  Cytotoxicity: y => ; compartment_*a*y;
  Immune_Kill: y => ; compartment_*Function_for_Immune_Kill(p, y, z);
  Stimulation:  => z; compartment_*Function_for_Stimulation(c, y, z);
  Clearance: z => ; compartment_*d*z;

  // Species initializations:
  x = 200;
  I = 0;
  y = 800;
  z = 100;

  // Compartment initializations:
  compartment_ = 1;

  // Variable initializations:
  r = 0.206;
  k = 2139;
  b = 0.000448;
  tau = 0;
  a = 1;
  p = 0.01;
  c = 0.02;
  d = 0.5;
  n = 0.01;

  // Other declarations:
  const compartment_, r, k, b, tau, a, p, c, d, n;

  // Unit definitions:
  unit volume = 1e-3 litre;
  unit time_unit = 86400 second;
  unit substance = 1e-3 mole;

  // Display Names:
  time_unit is "time";
  compartment_ is "compartment";

  // CV terms:
  compartment_ hypernym "http://identifiers.org/ncit/C94498"
  x hypernym "http://identifiers.org/cl/CL:0000000"
  I hypernym "http://identifiers.org/go/GO:0098689"
  y hypernym "http://identifiers.org/bto/BTO:0000152"
  z hypernym "http://identifiers.org/cl/CL:0000910"
  Uninfected_Cells_Proliferation hypernym "http://identifiers.org/ncit/C18081"
  Uninfected_Cells_Infection hypernym "http://identifiers.org/ncit/C3439"
  Length_of_Eclipse_Phase hypernym "http://identifiers.org/go/GO:0098689"
  Cytotoxicity hypernym "http://identifiers.org/ncit/C27988"
  Immune_Kill hypernym "http://identifiers.org/go/GO:0001906"
  Stimulation hypernym "http://identifiers.org/ncit/C39042"
  Clearance hypernym "http://identifiers.org/go/GO:0008219"
end

Wang2019_-_A_mathematical_model_of_oncolytic_virotherapy_with_time_delay is "Wang2019 - A mathematical model of oncolytic virotherapy with time delay"

Wang2019_-_A_mathematical_model_of_oncolytic_virotherapy_with_time_delay description "http://identifiers.org/pubmed/31137188"
Wang2019_-_A_mathematical_model_of_oncolytic_virotherapy_with_time_delay origin "http://identifiers.org/pubmed/11309314"
Wang2019_-_A_mathematical_model_of_oncolytic_virotherapy_with_time_delay model_entity_is "http://identifiers.org/biomodels.db/MODEL1908010001",
                                                                                         "http://identifiers.org/biomodels.db/BIOMD0000000772"
Wang2019_-_A_mathematical_model_of_oncolytic_virotherapy_with_time_delay property "http://identifiers.org/ncit/C62713"
Wang2019_-_A_mathematical_model_of_oncolytic_virotherapy_with_time_delay property "http://identifiers.org/mamo/MAMO_0000089"
