// Created by libAntimony v2.13.0
function Constant_flux__irreversible(v)
  v;
end

Constant_flux__irreversible is "Constant flux (irreversible)"

function Function_for_Tumor_Elimination(p, k, T_C, N)
  p*k*T_C*N;
end

Function_for_Tumor_Elimination is "Function_for_Tumor_Elimination"

function Function_for_T_Cytotoxic_Infiltration_Active(T_C, T_H)
  T_C*T_H;
end

Function_for_T_Cytotoxic_Infiltration_Active is "Function_for_T_Cytotoxic_Infiltration_Active"

function Function_for_T_Cytotoxic_Death(T_C)
  T_C;
end

Function_for_T_Cytotoxic_Death is "Function_for_T_Cytotoxic_Death"

function Function_for_T_Cytotoxic_Tumor_Infiltrate_Elimination(p, k, T_C, N)
  (1 - p)*k*T_C*N;
end

Function_for_T_Cytotoxic_Tumor_Infiltrate_Elimination is "Function_for_T_Cytotoxic_Tumor_Infiltrate_Elimination"

function Function_for_Tumor_Growth(gamma_, N)
  gamma_*(1 - N)*N;
end

Function_for_Tumor_Growth is "Function_for_Tumor_Growth"

function Function_for_T_Helper_Infiltration_Active(alpha, Ntilde, T_H, N)
  alpha*N*T_H/(Ntilde^2 + N^2);
end

Function_for_T_Helper_Infiltration_Active is "Function_for_T_Helper_Infiltration_Active"


model *L2V4_Model_of_Dritschel2018___A_mathematical_model_of_cytotoxic_and_helper_T_cell_interactions_in_a_tumour_microenvironment()

  // Compartments and Species:
  compartment compartment_;
  species N_Tumour in compartment_, T_H in compartment_, T_C in compartment_;

  // Reactions:
  Tumor_Growth:  => N_Tumour; compartment_*Function_for_Tumor_Growth(gamma_, N_Tumour);
  Tumor_Elimination: N_Tumour => ; compartment_*Function_for_Tumor_Elimination(p, k, T_C, N_Tumour);
  T_Helper_Infiltration_Passive:  => T_H; compartment_*Constant_flux__irreversible(sigma_H);
  T_Cytotoxic_Infiltration_Passive:  => T_C; compartment_*Constant_flux__irreversible(sigma_C);
  T_Cytotoxic_Infiltration_Active:  => T_C; compartment_*Function_for_T_Cytotoxic_Infiltration_Active(T_C, T_H);
  T_Helper_Infiltration_Active:  => T_H; compartment_*Function_for_T_Helper_Infiltration_Active(alpha, Ntilde, T_H, N_Tumour);
  T_Cytotoxic_Death: T_C => ; compartment_*Function_for_T_Cytotoxic_Death(T_C);
  T_Cytotoxic_Tumor_Infiltrate_Elimination: T_C => ; compartment_*Function_for_T_Cytotoxic_Tumor_Infiltrate_Elimination(p, k, T_C, N_Tumour);
  T_Helper_Death: T_H => ; compartment_*delta_H*T_H;

  // Species initializations:
  N_Tumour = 0.01;
  T_H = 0.6;
  T_C = 4.5;

  // Compartment initializations:
  compartment_ = 1;

  // Variable initializations:
  gamma_ = 10;
  p = 0.5;
  k = 4.15;
  sigma_H = 0.5;
  alpha = 0.19;
  Ntilde = 0.04;
  delta_H = 1;
  sigma_C = 2;

  // Other declarations:
  const compartment_, gamma_, p, k, sigma_H, alpha, Ntilde, delta_H, sigma_C;

  // Unit definitions:
  unit volume = 1e-3 litre;
  unit time_unit = 86400 second;
  unit substance = 1e-3 mole;

  // Display Names:
  time_unit is "time";
  compartment_ is "compartment";
  gamma_ is "gamma";

  // CV terms:
  compartment_ hypernym "http://identifiers.org/ncit/C94498"
  N_Tumour hypernym "http://identifiers.org/ncit/C12922"
  T_H hypernym "http://identifiers.org/cl/CL:0000912"
  T_C hypernym "http://identifiers.org/cl/CL:0000910"
  Tumor_Growth hypernym "http://identifiers.org/ncit/C18081"
  Tumor_Elimination hypernym "http://identifiers.org/sbo/SBO:0000179"
  Tumor_Elimination hypernym "http://identifiers.org/ncit/C18246"
  T_Helper_Infiltration_Passive hypernym "http://identifiers.org/go/GO:0035684"
  T_Cytotoxic_Infiltration_Passive hypernym "http://identifiers.org/go/GO:0072683"
  T_Cytotoxic_Infiltration_Active hypernym "http://identifiers.org/go/GO:0072683"
  T_Helper_Infiltration_Active hypernym "http://identifiers.org/go/GO:0035684"
  T_Cytotoxic_Death hypernym "http://identifiers.org/go/GO:0008219"
  T_Cytotoxic_Tumor_Infiltrate_Elimination hypernym "http://identifiers.org/go/GO:0008219"
  T_Helper_Death hypernym "http://identifiers.org/go/GO:0008219"
end

L2V4_Model_of_Dritschel2018___A_mathematical_model_of_cytotoxic_and_helper_T_cell_interactions_in_a_tumour_microenvironment is "Dritschel2018 - A mathematical model of cytotoxic and helper T cell interactions in a tumour microenvironment"

L2V4_Model_of_Dritschel2018___A_mathematical_model_of_cytotoxic_and_helper_T_cell_interactions_in_a_tumour_microenvironment description "http://identifiers.org/doi/10.1080/23737867.2018.1465863"
L2V4_Model_of_Dritschel2018___A_mathematical_model_of_cytotoxic_and_helper_T_cell_interactions_in_a_tumour_microenvironment origin "http://identifiers.org/pubmed/8186756"
L2V4_Model_of_Dritschel2018___A_mathematical_model_of_cytotoxic_and_helper_T_cell_interactions_in_a_tumour_microenvironment model_entity_is "http://identifiers.org/biomodels.db/MODEL1907230003",
                                                                                                                                            "http://identifiers.org/biomodels.db/BIOMD0000000763"
L2V4_Model_of_Dritschel2018___A_mathematical_model_of_cytotoxic_and_helper_T_cell_interactions_in_a_tumour_microenvironment hypernym "http://identifiers.org/mamo/MAMO_0000046"
L2V4_Model_of_Dritschel2018___A_mathematical_model_of_cytotoxic_and_helper_T_cell_interactions_in_a_tumour_microenvironment hypernym "http://identifiers.org/go/GO:0002424"
