// Created by libAntimony v2.13.0
function Constant_flux__irreversible(v)
  v;
end

Constant_flux__irreversible is "Constant flux (irreversible)"

function stimulation(p, T, E, g)
  p*T*E/(g + T);
end

stimulation is "stimulation"

function t_d(a, b, T)
  a*b*T*T;
end

t_d is "t-d"

function growth(a, T)
  a*T;
end

growth is "growth"

function interaction(k, sub, mod)
  k*sub*mod;
end

interaction is "interaction"


model *Figueredo2013_1___immunointeraction_base_model()

  // Compartments and Species:
  compartment tumor_microenvironment;
  species T in tumor_microenvironment, E in tumor_microenvironment;

  // Reactions:
  tumor_growth:  => T; tumor_microenvironment*growth(a, T);
  tumor_death: T => ; tumor_microenvironment*t_d(a, b, T);
  tumor_killing: T => ; tumor_microenvironment*interaction(n, T, E);
  immune_stimulation:  => E; tumor_microenvironment*stimulation(p, T, E, g);
  immune_exhaustion: E => ; tumor_microenvironment*interaction(m, E, T);
  immune_death: E => ; tumor_microenvironment*d*E;
  immune_source:  => E; tumor_microenvironment*Constant_flux__irreversible(s);

  // Species initializations:
  T = 50;
  T has substance_per_volume;
  E = 5;
  E has substance_per_volume;

  // Compartment initializations:
  tumor_microenvironment = 1;
  tumor_microenvironment has volume;

  // Variable initializations:
  a = 1.636;
  a has unit_0;
  b = 0.004;
  b has unit_0;
  n = 1;
  n has unit_0;
  p = 1.131;
  p has unit_0;
  g = 20.19;
  g has unit_0;
  m = 0.00311;
  m has unit_0;
  d = 2;
  d has unit_0;
  s = 0.318;
  s has unit_0;

  // Other declarations:
  const tumor_microenvironment, a, b, n, p, g, m, d, s;

  // Unit definitions:
  unit length = metre;
  unit area = metre^2;
  unit volume = 1e-3 litre;
  unit time_unit = time_unit;
  unit substance = 1e-3 mole;
  unit unit_0 = 1 / dimensionless^-0;
  unit extent = substance;
  unit substance_per_volume = 1e-3 mole / 1e-3 litre;

  // Display Names:
  time_unit is "time";
  unit_0 is "1";
  tumor_microenvironment is "tumor microenvironment";
  tumor_growth is "tumor growth";
  tumor_death is "tumor death";
  tumor_killing is "tumor killing";
  immune_stimulation is "immune stimulation";
  immune_exhaustion is "immune exhaustion";
  immune_death is "immune death";
  immune_source is "immune source";

  // CV terms:
  tumor_microenvironment hypernym "http://identifiers.org/ncit/C94498"
  T hypernym "http://identifiers.org/cl/CL:0001064"
  E hypernym "http://identifiers.org/ncit/C28241"
  a hypernym "http://identifiers.org/sbo/SBO:0000610"
  b hypernym "http://identifiers.org/ncit/C53346"
  p hypernym "http://identifiers.org/sbo/SBO:0000610"
  g hypernym "http://identifiers.org/sbo/SBO:0000193"
  m hypernym "http://identifiers.org/ncit/C53346"
  d hypernym "http://identifiers.org/ncit/C53346"
  s hypernym "http://identifiers.org/sbo/SBO:0000610"
  tumor_growth hypernym "http://identifiers.org/go/GO:0008283"
  tumor_growth hypernym "http://identifiers.org/sbo/SBO:0000393"
  tumor_death hypernym "http://identifiers.org/go/GO:0008219"
  tumor_death hypernym "http://identifiers.org/sbo/SBO:0000179"
  tumor_killing hypernym "http://identifiers.org/go/GO:0002419"
  tumor_killing hypernym "http://identifiers.org/sbo/SBO:0000179"
  immune_stimulation hypernym "http://identifiers.org/sbo/SBO:0000393"
  immune_stimulation hypernym "http://identifiers.org/go/GO:0008283"
  immune_exhaustion hypernym "http://identifiers.org/go/GO:0008219"
  immune_exhaustion hypernym "http://identifiers.org/sbo/SBO:0000179"
  immune_death hypernym "http://identifiers.org/sbo/SBO:0000179"
  immune_death hypernym "http://identifiers.org/go/GO:0008219"
  immune_source hypernym "http://identifiers.org/sbo/SBO:0000393"
  immune_source hypernym "http://identifiers.org/go/GO:0008283"
end

Figueredo2013_1___immunointeraction_base_model is "Figueredo2013/1 - immunointeraction base model"

Figueredo2013_1___immunointeraction_base_model description "http://identifiers.org/pubmed/23734575"
Figueredo2013_1___immunointeraction_base_model model_entity_is "http://identifiers.org/biomodels.db/MODEL1907180001",
                                                               "http://identifiers.org/biomodels.db/BIOMD0000000753"
Figueredo2013_1___immunointeraction_base_model hypernym "http://identifiers.org/go/GO:0002418"
Figueredo2013_1___immunointeraction_base_model property "http://identifiers.org/mamo/MAMO_0000046"
Figueredo2013_1___immunointeraction_base_model taxon "http://identifiers.org/taxonomy/9606"
