// Created by libAntimony v2.13.0
function growth_immune(y, I, Ie, u, C, R)
  y*I*(1 - I/(Ie + u*(C + 0.001*R)*I));
end

growth_immune is "growth immune"

function killing(a0, C, I)
  a0*C*I;
end

killing is "killing"

function logistic_growth(K, k, mod, pro)
  k*pro*(1 - (pro + mod)/K);
end

logistic_growth is "logistic growth"


model *Wilkie2013r___immune_induced_cancer_dormancy_and_immune_evasion_resistance()

  // Compartments and Species:
  compartment tumor_microenvironment;
  species C in tumor_microenvironment, I in tumor_microenvironment, R in tumor_microenvironment;

  // Assignment Rules:
  b0 := a0*f;

  // Reactions:
  immune_growth:  => I; tumor_microenvironment*growth_immune(y, I, Ie, u, C, R);
  cancer_logistic_growth:  => C; tumor_microenvironment*logistic_growth(K, a, R, C);
  cancer_killing: C => ; tumor_microenvironment*killing(a0, C, I);
  resistant_logistic_growth:  => R; tumor_microenvironment*logistic_growth(K, b, C, R);
  resistant_killing: R => ; tumor_microenvironment*killing(b0, R, I);

  // Species initializations:
  C = 9000;
  C has substance_per_volume;
  I = 100;
  I has substance_per_volume;
  R = 1000;
  R has substance_per_volume;

  // Compartment initializations:
  tumor_microenvironment = 1;
  tumor_microenvironment has volume;

  // Variable initializations:
  a = 0.2;
  a has unit_0;
  K = 10000000000;
  K has unit_0;
  a0 = 0.0001;
  a0 has unit_0;
  y = 0.2;
  y has unit_0;
  Ie = 100;
  Ie has unit_0;
  u = 0.001;
  u has unit_0;
  b = 0.2;
  b has unit_0;
  b0 has unit_0;
  f = 1;
  f has unit_0;

  // Other declarations:
  var b0;
  const tumor_microenvironment, a, K, a0, y, Ie, u, b, f;

  // Unit definitions:
  unit length = metre;
  unit area = metre^2;
  unit volume = 1e-3 litre;
  unit time_unit = time_unit;
  unit substance = 1e-3 mole;
  unit unit_0 = 1 / dimensionless^-0;
  unit extent = substance;
  unit substance_per_volume = 1e-3 mole / 1e-3 litre;

  // Display Names:
  time_unit is "time";
  unit_0 is "1";
  tumor_microenvironment is "tumor microenvironment";
  immune_growth is "immune growth";
  cancer_logistic_growth is "cancer logistic growth";
  cancer_killing is "cancer killing";
  resistant_logistic_growth is "resistant logistic growth";
  resistant_killing is "resistant killing";

  // CV terms:
  tumor_microenvironment hypernym "http://identifiers.org/ncit/C94498"
  C hypernym "http://identifiers.org/cl/CL:0001064"
  I hypernym "http://identifiers.org/ncit/C28241"
  R hypernym "http://identifiers.org/cl/CL:0001064"
  a hypernym "http://identifiers.org/sbo/SBO:0000610"
  K hypernym "http://identifiers.org/sbo/SBO:0000661"
  a0 hypernym "http://identifiers.org/ncit/C25201"
  y hypernym "http://identifiers.org/sbo/SBO:0000610"
  Ie hypernym "http://identifiers.org/sbo/SBO:0000193"
  u hypernym "http://identifiers.org/ncit/C64638"
  b hypernym "http://identifiers.org/sbo/SBO:0000610"
  b0 hypernym "http://identifiers.org/ncit/C25201"
  f hypernym "http://identifiers.org/ncit/C44256"
  immune_growth hypernym "http://identifiers.org/sbo/SBO:0000393"
  cancer_logistic_growth hypernym "http://identifiers.org/sbo/SBO:0000393"
  cancer_logistic_growth hypernym "http://identifiers.org/go/GO:0008283"
  cancer_killing hypernym "http://identifiers.org/go/GO:0002419"
  cancer_killing hypernym "http://identifiers.org/sbo/SBO:0000179"
  resistant_logistic_growth hypernym "http://identifiers.org/sbo/SBO:0000393"
  resistant_logistic_growth hypernym "http://identifiers.org/go/GO:0008283"
  resistant_killing hypernym "http://identifiers.org/go/GO:0002419"
  resistant_killing hypernym "http://identifiers.org/sbo/SBO:0000179"
end

Wilkie2013r___immune_induced_cancer_dormancy_and_immune_evasion_resistance is "Wilkie2013r - immune-induced cancer dormancy and immune evasion-resistance"

Wilkie2013r___immune_induced_cancer_dormancy_and_immune_evasion_resistance description "http://identifiers.org/pubmed/24511375"
Wilkie2013r___immune_induced_cancer_dormancy_and_immune_evasion_resistance model_entity_is "http://identifiers.org/biomodels.db/MODEL1907170001",
                                                                                           "http://identifiers.org/biomodels.db/BIOMD0000000752"
Wilkie2013r___immune_induced_cancer_dormancy_and_immune_evasion_resistance hypernym "http://identifiers.org/go/GO:0002418"
Wilkie2013r___immune_induced_cancer_dormancy_and_immune_evasion_resistance property "http://identifiers.org/mamo/MAMO_0000046"
Wilkie2013r___immune_induced_cancer_dormancy_and_immune_evasion_resistance taxon "http://identifiers.org/taxonomy/9606"
