// Created by libAntimony v2.13.0
model *BIOMD0000000641()

  // Compartments and Species:
  compartment nucleus;
  species $Timeract in nucleus, $Damage in nucleus, $Timerinact in nucleus;
  species $Timertot in nucleus, $CellCact in nucleus, $CellCina in nucleus;
  species $Effectoract in nucleus, $CellCycletot in nucleus, $Effectorina in nucleus;
  species $Effectortot in nucleus, $HR in nucleus, $NHEJ in nucleus;

  // Assignment Rules:
  Damage := HR + NHEJ;
  Timerinact := Timertot - Timeract;
  CellCina := CellCycletot - CellCact;
  Effectorina := Effectortot - Effectoract;

  // Rate Rules:
  Timeract' = Kd2t*Damage*Timerinact/(Km1 + Timerinact) - Kti2t*Timeract/(Km1 + Timeract);
  CellCact' = (Kcc2a + CellCact)*CellCina/(Km10 + CellCina) - Kt2cc*Timeract*CellCact/(Km10 + CellCact) - Kch2cc*CellCact*Effectoract/(Km10 + CellCact);
  Effectoract' = Kd2ch*Damage*Effectorina/(Km10 + Effectorina) - Kcc2ch*CellCact*Effectoract/(Km10 + Effectoract);
  HR' = -HR*0.2;
  NHEJ' = -NHEJ*0.5;

  // Species initializations:
  Timeract = 0;
  Timeract has substance_per_volume;
  Damage has substance_per_volume;
  Timerinact has substance_per_volume;
  Timertot = 10;
  Timertot has substance_per_volume;
  CellCact = 0.999999999999999;
  CellCact has substance_per_volume;
  CellCina has substance_per_volume;
  Effectoract = 0;
  Effectoract has substance_per_volume;
  CellCycletot = 10;
  CellCycletot has substance_per_volume;
  Effectorina has substance_per_volume;
  Effectortot = 10;
  Effectortot has substance_per_volume;
  HR = 3;
  HR has substance_per_volume;
  NHEJ = 7;
  NHEJ has substance_per_volume;

  // Compartment initializations:
  nucleus = 1;
  nucleus has volume;

  // Variable initializations:
  Kd2t = 2;
  Km1 = 1;
  Kti2t = 10;
  Kcc2a = 1;
  Km10 = 10;
  Kt2cc = 10;
  Kch2cc = 1;
  Kd2ch = 1;
  Kcc2ch = 1;

  // Other declarations:
  const nucleus, Kd2t, Km1, Kti2t, Kcc2a, Km10, Kt2cc, Kch2cc, Kd2ch, Kcc2ch;

  // Unit definitions:
  unit length = metre;
  unit area = metre^2;
  unit volume = 1e-3 litre;
  unit time_unit = time_unit;
  unit substance = 1e-3 mole;
  unit extent = substance;
  unit substance_per_volume = 1e-3 mole / 1e-3 litre;

  // Display Names:
  time_unit is "time";

  // CV terms:
  nucleus hypernym "http://identifiers.org/go/GO:0005634"
  Timeract hypernym "http://identifiers.org/uniprot/Q13315"
  Damage property "http://identifiers.org/go/GO:0042769"
  Timerinact hypernym "http://identifiers.org/uniprot/Q13315"
  Timertot hypernym "http://identifiers.org/uniprot/Q13315"
  CellCact hypernym "http://identifiers.org/uniprot/P53350"
  CellCina hypernym "http://identifiers.org/uniprot/P53350"
  Effectoract hypernym "http://identifiers.org/uniprot/Q13535"
  CellCycletot hypernym "http://identifiers.org/uniprot/P53350"
  Effectorina hypernym "http://identifiers.org/uniprot/Q13535"
  Effectortot hypernym "http://identifiers.org/uniprot/Q13535"
  HR hypernym "http://identifiers.org/go/GO:0000724"
  NHEJ hypernym "http://identifiers.org/go/GO:0006303"
end

BIOMD0000000641 is "Jaiswal2017 - Cell cycle arrest"

BIOMD0000000641 model_entity_is "http://identifiers.org/biomodels.db/MODEL1704030000"
BIOMD0000000641 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000641"
BIOMD0000000641 description "http://identifiers.org/pubmed/28607002"
BIOMD0000000641 hypernym "http://identifiers.org/go/GO:0007095",
                         "urn:miriam:pw:+PW%3A0001362"
BIOMD0000000641 container "http://identifiers.org/bto/BTO:0004910"
BIOMD0000000641 property "urn:miriam:mamo:MAMO%3A0000046"
BIOMD0000000641 taxon "http://identifiers.org/taxonomy/9606"
