// Created by libAntimony v2.13.0
function Constant_flux__irreversible(v)
  v;
end

Constant_flux__irreversible is "Constant flux (irreversible)"

function Menten_Explicit_Enzyme_12(Kcat, km, species_0, species_15)
  Kcat*species_0*species_15/(km + species_15);
end

Menten_Explicit_Enzyme_12 is "Menten_Explicit_Enzyme_12"

function MM_Explicit_Enzyme_5(kcat, km, species_23, species_27)
  kcat*species_27*species_23/(km + species_23);
end

MM_Explicit_Enzyme_5 is "MM Explicit Enzyme_5"

function Menten_Explicit_Enzyme_14(Kcat, km, species_14, species_17)
  Kcat*species_14*species_17/(km + species_17);
end

Menten_Explicit_Enzyme_14 is "Menten_Explicit_Enzyme_14"

function Menten_Explicit_Enzyme_9(Kcat, km, species_10, species_26)
  Kcat*species_26*species_10/(km + species_10);
end

Menten_Explicit_Enzyme_9 is "Menten_Explicit_Enzyme_9"

function MM_Explicit_Enzyme_7(kcat, km, species_24, species_4)
  kcat*species_4*species_24/(km + species_24);
end

MM_Explicit_Enzyme_7 is "MM Explicit Enzyme_7"

function Menten_Explicit_Enzyme_4(Kcat, km, species_4, species_7)
  Kcat*species_4*species_7/(km + species_7);
end

Menten_Explicit_Enzyme_4 is "Menten_Explicit_Enzyme_4"

function Menten_Explicit_Enzyme_6(Kcat, km, species_6, species_9)
  Kcat*species_6*species_9/(km + species_9);
end

Menten_Explicit_Enzyme_6 is "Menten_Explicit_Enzyme_6"

function MM_Explicit_Enzyme_4(kcat, km, species_21, species_24)
  kcat*species_21*species_24/(km + species_24);
end

MM_Explicit_Enzyme_4 is "MM Explicit Enzyme_4"

function Menten_Explicit_Enzyme_2(Kcat, km, species_2, species_5)
  Kcat*species_2*species_5/(km + species_5);
end

Menten_Explicit_Enzyme_2 is "Menten_Explicit_Enzyme_2"

function Menten_Explicit_Enzyme_7(Kcat, km, species_26, species_8)
  Kcat*species_26*species_8/(km + species_8);
end

Menten_Explicit_Enzyme_7 is "Menten_Explicit_Enzyme_7"

function Menten_Explicit_Enzyme_11(Kcat, km, species_12, species_2)
  Kcat*species_12*species_2/(km + species_2);
end

Menten_Explicit_Enzyme_11 is "Menten_Explicit_Enzyme_11"

function Menten_Explicit_Enzyme_15(Kcat, km, species_16, species_6)
  Kcat*species_16*species_6/(km + species_6);
end

Menten_Explicit_Enzyme_15 is "Menten_Explicit_Enzyme_15"

function MM_Explicit_Enzyme_1(kcat, km, species_0, species_20)
  kcat*species_0*species_20/(km + species_20);
end

MM_Explicit_Enzyme_1 is "MM Explicit Enzyme_1"

function Menten_Explicit_Enzyme_10(Kcat, km, species_10, species_13)
  Kcat*species_10*species_13/(km + species_13);
end

Menten_Explicit_Enzyme_10 is "Menten_Explicit_Enzyme_10"

function Menten_Explicit_Enzyme_5(Kcat, km, species_27, species_6)
  Kcat*species_27*species_6/(km + species_6);
end

Menten_Explicit_Enzyme_5 is "Menten_Explicit_Enzyme_5"

function Menten_Explicit_Enzyme_8(Kcat, km, species_11, species_8)
  Kcat*species_8*species_11/(km + species_11);
end

Menten_Explicit_Enzyme_8 is "Menten_Explicit_Enzyme_8"

function Menten_Explicit_Enzyme_13(Kcat, km, species_15, species_4)
  Kcat*species_4*species_15/(km + species_15);
end

Menten_Explicit_Enzyme_13 is "Menten_Explicit_Enzyme_13"

function Menten_Explicit_Enzyme_3(Kcat, km, species_28, species_4)
  Kcat*species_28*species_4/(km + species_4);
end

Menten_Explicit_Enzyme_3 is "Menten_Explicit_Enzyme_3"

function MM_Explicit_Enzyme_2(kcat, km, species_19, species_22)
  kcat*species_19*species_22/(km + species_22);
end

MM_Explicit_Enzyme_2 is "MM Explicit Enzyme_2"

function Menten_Explicit_Enzyme_1(Kcat, km, species_0, species_3)
  Kcat*species_0*species_3/(km + species_3);
end

Menten_Explicit_Enzyme_1 is "Menten_Explicit_Enzyme_1"

function MM_Explicit_Enzyme_3(kcat, km, species_21, species_29)
  kcat*species_29*species_21/(km + species_21);
end

MM_Explicit_Enzyme_3 is "MM Explicit Enzyme_3"

function MM_Explicit_Enzyme_6(kcat, km, species_23, species_9)
  kcat*species_23*species_9/(km + species_9);
end

MM_Explicit_Enzyme_6 is "MM Explicit Enzyme_6"


model *MODEL1611280000()

  // Compartments and Species:
  compartment compartment_0;
  species species_0 in compartment_0, species_1 in compartment_0, species_2 in compartment_0;
  species species_3 in compartment_0, species_4 in compartment_0, species_5 in compartment_0;
  species species_6 in compartment_0, species_7 in compartment_0, species_8 in compartment_0;
  species species_9 in compartment_0, species_10 in compartment_0, species_11 in compartment_0;
  species species_12 in compartment_0, species_13 in compartment_0, species_14 in compartment_0;
  species species_15 in compartment_0, species_16 in compartment_0, species_17 in compartment_0;
  species species_18 in compartment_0, species_19 in compartment_0, species_20 in compartment_0;
  species species_21 in compartment_0, species_22 in compartment_0, species_23 in compartment_0;
  species species_24 in compartment_0, $species_25 in compartment_0, $species_26 in compartment_0;
  species $species_27 in compartment_0, $species_28 in compartment_0, $species_29 in compartment_0;
  species $species_30 in compartment_0;

  // Reactions:
  reaction_0: $species_25 + species_1 -> species_0; compartment_0*(reaction_0_k1*species_25*species_1 - reaction_0_k2*species_0);
  reaction_1: species_3 => species_2; compartment_0*Menten_Explicit_Enzyme_1(reaction_1_Kcat, reaction_1_km, species_0, species_3);
  reaction_2: species_2 => species_3; compartment_0*reaction_2_k1*species_2;
  reaction_3: species_5 => species_4; compartment_0*Menten_Explicit_Enzyme_2(reaction_3_Kcat, reaction_3_km, species_2, species_5);
  reaction_4: species_4 => species_5; compartment_0*Menten_Explicit_Enzyme_3(reaction_4_Kcat, reaction_4_km, species_28, species_4);
  reaction_5: species_7 => species_6; compartment_0*Menten_Explicit_Enzyme_4(reaction_5_Kcat, reaction_5_km, species_4, species_7);
  reaction_6: species_6 => species_7; compartment_0*Menten_Explicit_Enzyme_5(reaction_6_Kcat, reaction_6_km, species_27, species_6);
  reaction_7: species_9 => species_8; compartment_0*Menten_Explicit_Enzyme_6(reaction_7_Kcat, reaction_7_km, species_6, species_9);
  reaction_8: species_8 => species_9; compartment_0*Menten_Explicit_Enzyme_7(reaction_8_Kcat, reaction_8_km, species_26, species_8);
  reaction_9: species_11 => species_10; compartment_0*Menten_Explicit_Enzyme_8(reaction_9_Kcat, reaction_9_km, species_11, species_8);
  reaction_10: species_10 => species_11; compartment_0*Menten_Explicit_Enzyme_9(reaction_10_Kcat, reaction_10_km, species_10, species_26);
  reaction_11: species_13 => species_12; compartment_0*Menten_Explicit_Enzyme_10(reaction_11_Kcat, reaction_11_km, species_10, species_13);
  reaction_12: species_12 => species_13; compartment_0*reaction_12_k1*species_12;
  reaction_13: species_2 => species_3; compartment_0*Menten_Explicit_Enzyme_11(reaction_13_Kcat, reaction_13_km, species_12, species_2);
  reaction_14: species_15 => species_14; compartment_0*Menten_Explicit_Enzyme_12(reaction_14_Kcat, reaction_14_km, species_0, species_15);
  reaction_15: species_15 => species_14; compartment_0*Menten_Explicit_Enzyme_13(reaction_15_Kcat, reaction_15_km, species_15, species_4);
  reaction_16: species_14 => species_15; compartment_0*reaction_16_k1*species_14;
  reaction_17: species_17 => species_16; compartment_0*Menten_Explicit_Enzyme_14(reaction_17_Kcat, reaction_17_km, species_14, species_17);
  reaction_18: species_16 => species_17; compartment_0*reaction_18_k1*species_16;
  reaction_19: species_6 => species_7; compartment_0*Menten_Explicit_Enzyme_15(reaction_19_Kcat, reaction_19_km, species_16, species_6);
  reaction_20: species_0 => species_18; compartment_0*reaction_20_k1*species_0;
  reaction_21: species_20 => species_19; compartment_0*MM_Explicit_Enzyme_1(reaction_21_kcat, reaction_21_km, species_0, species_20);
  reaction_22: species_19 => species_20; compartment_0*reaction_22_k1*species_19;
  reaction_23: species_22 => species_21; compartment_0*MM_Explicit_Enzyme_2(reaction_23_kcat, reaction_23_km, species_19, species_22);
  reaction_24: species_21 => species_22; compartment_0*MM_Explicit_Enzyme_3(reaction_24_kcat, reaction_24_km, species_21, species_29);
  reaction_25: species_24 => species_23; compartment_0*MM_Explicit_Enzyme_4(reaction_25_kcat, reaction_25_km, species_21, species_24);
  reaction_26: species_23 => species_24; compartment_0*MM_Explicit_Enzyme_5(reaction_26_kcat, reaction_26_km, species_23, species_27);
  reaction_27: species_9 => species_8; compartment_0*MM_Explicit_Enzyme_6(reaction_27_kcat, reaction_27_km, species_23, species_9);
  reaction_28: $species_30 => species_1; compartment_0*Constant_flux__irreversible(reaction_28_v);
  reaction_29: species_1 => species_18; compartment_0*reaction_29_k1*species_1;
  reaction_30: species_24 => species_23; compartment_0*MM_Explicit_Enzyme_7(reaction_30_kcat, reaction_30_km, species_24, species_4);

  // Species initializations:
  species_0 = 0;
  species_1 = 80000;
  species_2 = 0;
  species_3 = 120000;
  species_4 = 0;
  species_5 = 120000;
  species_6 = 0;
  species_7 = 120000;
  species_8 = 0;
  species_9 = 600000;
  species_10 = 0;
  species_11 = 600000;
  species_12 = 0;
  species_13 = 120000;
  species_14 = 0;
  species_15 = 120000;
  species_16 = 0;
  species_17 = 120000;
  species_18 = 0;
  species_19 = 0;
  species_20 = 120000;
  species_21 = 0;
  species_22 = 120000;
  species_23 = 0;
  species_24 = 120000;
  species_25 = 10002000;
  species_26 = 120000;
  species_27 = 120000;
  species_28 = 120000;
  species_29 = 120000;
  species_30 = 1;

  // Compartment initializations:
  compartment_0 = 1;

  // Variable initializations:
  reaction_0_k1 = 2.18503e-05;
  reaction_0_k2 = 0.121008;
  reaction_1_Kcat = 694.731;
  reaction_1_km = 6086070;
  reaction_2_k1 = 2.5;
  reaction_3_Kcat = 32.344;
  reaction_3_km = 35954.3;
  reaction_4_Kcat = 1509.36;
  reaction_4_km = 1432410;
  reaction_5_Kcat = 0.884096;
  reaction_5_km = 62464.6;
  reaction_6_Kcat = 0.126329;
  reaction_6_km = 1061.71;
  reaction_7_Kcat = 185.759;
  reaction_7_km = 4768350;
  reaction_8_Kcat = 2.83243;
  reaction_8_km = 518753;
  reaction_9_Kcat = 9.85367;
  reaction_9_km = 1007340;
  reaction_10_Kcat = 8.8912;
  reaction_10_km = 3496490;
  reaction_11_Kcat = 0.0213697;
  reaction_11_km = 763523;
  reaction_12_k1 = 0.005;
  reaction_13_Kcat = 1611.97;
  reaction_13_km = 896896;
  reaction_14_Kcat = 10.6737;
  reaction_14_km = 184912;
  reaction_15_Kcat = 0.0771067;
  reaction_15_km = 272056;
  reaction_16_k1 = 0.005;
  reaction_17_Kcat = 0.0566279;
  reaction_17_km = 653951;
  reaction_18_k1 = 0.005;
  reaction_19_Kcat = 15.1212;
  reaction_19_km = 119355;
  reaction_20_k1 = 0.2;
  reaction_21_kcat = 694.731;
  reaction_21_km = 6086070;
  reaction_22_k1 = 2.5;
  reaction_23_kcat = 32.344;
  reaction_23_km = 35954.3;
  reaction_24_kcat = 1509.36;
  reaction_24_km = 1432410;
  reaction_25_kcat = 0.884096;
  reaction_25_km = 62464.6;
  reaction_26_kcat = 0.126329;
  reaction_26_km = 1061.71;
  reaction_27_kcat = 185.759;
  reaction_27_km = 4768350;
  reaction_28_v = 100;
  reaction_29_k1 = 0.00125;
  reaction_30_kcat = 0.884096;
  reaction_30_km = 62464.6;

  // Other declarations:
  const compartment_0;

  // Unit definitions:
  unit volume = 1e-3 litre;
  unit time_unit = 60 second;
  unit substance = 1e-3 mole;

  // Display Names:
  time_unit is "time";
  compartment_0 is "compartment";
  species_0 is "boundEGFReceptor";
  species_1 is "freeEGFReceptor";
  species_2 is "SosActive";
  species_3 is "SosInactive";
  species_4 is "RasActive";
  species_5 is "RasInactive";
  species_6 is "Raf1Active";
  species_7 is "Raf1Inactive";
  species_8 is "MekActive";
  species_9 is "MekInactive";
  species_10 is "ErkActive";
  species_11 is "ErkInactive";
  species_12 is "P90RskActive";
  species_13 is "P90RskInactive";
  species_14 is "PI3KActive";
  species_15 is "PI3KInactive";
  species_16 is "AktActive";
  species_17 is "AktInactive";
  species_18 is "degradedEGFReceptor";
  species_19 is "C3GActive";
  species_20 is "C3GInactive";
  species_21 is "Rap1Active";
  species_22 is "Rap1Inactive";
  species_23 is "bRafActive";
  species_24 is "bRafInactive";
  species_25 is "EGF";
  species_26 is "PP2AActive";
  species_27 is "Raf1PPtase";
  species_28 is "RasGapActive";
  species_29 is "Rap1Gap";
  species_30 is "proEGFReceptor";
  reaction_0 is "EGF_Binding_Unbinding";
  reaction_1 is "Sos_Activation";
  reaction_2 is "Sos_Deactivation";
  reaction_3 is "Ras_Activation";
  reaction_4 is "Ras_Deactivation";
  reaction_5 is "Raf1_Activation";
  reaction_6 is "Raf1_Deactivation";
  reaction_7 is "Mek_Activation";
  reaction_8 is "Mek_Deactivation";
  reaction_9 is "Erk_Activation";
  reaction_10 is "Erk_Deactivation";
  reaction_11 is "P90Rsk_Activation";
  reaction_12 is "P90Rsk_Deactivation";
  reaction_13 is "Sos_Feedback_Deactivation";
  reaction_14 is "PI3K_Activation_EGFR";
  reaction_15 is "PI3K_Activation_Ras";
  reaction_16 is "PI3K_Deactivation";
  reaction_17 is "Akt_Activation";
  reaction_18 is "Akt_Deactivation";
  reaction_19 is "Raf1_Deactivation_Akt";
  reaction_20 is "EGFReceptor_Degradation";
  reaction_21 is "C3G_Activation";
  reaction_22 is "C3G_Deactivation";
  reaction_23 is "Rap1_Activation";
  reaction_24 is "Rap1_Deactivation";
  reaction_25 is "bRaf_Activation";
  reaction_26 is "bRaf_Deactivation";
  reaction_27 is "Mek_Activation_bRaf";
  reaction_28 is "EGFReceptor_Production";
  reaction_29 is "EGFReceptor_Degradtion_Free";
  reaction_30 is "bRaf_Activation_Ras";

  // CV terms:
  compartment_0 model_entity_is "http://identifiers.org/go/GO:0005623"
  species_0 hypernym "http://identifiers.org/uniprot/Q9QX70"
  species_1 hypernym "http://identifiers.org/uniprot/Q9QX70"
  species_2 hypernym "http://identifiers.org/uniprot/Q9Z1I1"
  species_3 hypernym "http://identifiers.org/uniprot/Q9Z1I1"
  species_4 hypernym "http://identifiers.org/interpro/IPR020849"
  species_5 hypernym "http://identifiers.org/interpro/IPR020849"
  species_6 hypernym "http://identifiers.org/uniprot/P11345"
  species_7 hypernym "http://identifiers.org/uniprot/P11345"
  species_8 hypernym "http://identifiers.org/uniprot/P36506"
  species_8 hypernym "http://identifiers.org/uniprot/Q01986"
  species_9 hypernym "http://identifiers.org/uniprot/Q01986"
  species_9 hypernym "http://identifiers.org/uniprot/P36506"
  species_10 hypernym "http://identifiers.org/uniprot/P63086"
  species_10 hypernym "http://identifiers.org/uniprot/P21708"
  species_11 hypernym "http://identifiers.org/uniprot/P21708"
  species_11 hypernym "http://identifiers.org/uniprot/P63086"
  species_12 hypernym "http://identifiers.org/uniprot/Q9Z1I2"
  species_12 hypernym "http://identifiers.org/uniprot/Q63531"
  species_13 hypernym "http://identifiers.org/uniprot/Q9Z1I2"
  species_13 hypernym "http://identifiers.org/uniprot/Q63531"
  species_14 hypernym "http://identifiers.org/uniprot/Q63787"
  species_15 hypernym "http://identifiers.org/uniprot/Q63787"
  species_16 hypernym "http://identifiers.org/uniprot/P47196"
  species_16 hypernym "http://identifiers.org/uniprot/P47197"
  species_16 hypernym "http://identifiers.org/uniprot/Q63484"
  species_17 hypernym "http://identifiers.org/uniprot/Q63484"
  species_17 hypernym "http://identifiers.org/uniprot/P47197"
  species_17 hypernym "http://identifiers.org/uniprot/P47196"
  species_18 hypernym "http://identifiers.org/uniprot/Q9QX70"
  species_19 hypernym "http://identifiers.org/uniprot/Q9QYV3"
  species_20 hypernym "http://identifiers.org/uniprot/Q9QYV3"
  species_21 hypernym "http://identifiers.org/uniprot/Q62636"
  species_22 hypernym "http://identifiers.org/uniprot/Q62636"
  species_23 hypernym "http://identifiers.org/uniprot/F1M9C3"
  species_24 hypernym "http://identifiers.org/uniprot/F1M9C3"
  species_25 hypernym "http://identifiers.org/uniprot/P07522"
  species_26 hypernym "http://identifiers.org/go/GO:0000159"
  species_27 hypernym "http://identifiers.org/go/GO:1903293"
  species_28 hypernym "http://identifiers.org/uniprot/P50904"
  species_29 hypernym "http://identifiers.org/uniprot/F1LV89"
  species_30 hypernym "http://identifiers.org/uniprot/Q9QX70"
  reaction_0 identity "http://identifiers.org/sbo/SBO:0000012"
  reaction_1 identity "http://identifiers.org/sbo/SBO:0000029"
  reaction_2 identity "http://identifiers.org/sbo/SBO:0000012"
  reaction_3 identity "http://identifiers.org/sbo/SBO:0000029"
  reaction_4 identity "http://identifiers.org/sbo/SBO:0000029"
  reaction_5 identity "http://identifiers.org/sbo/SBO:0000029"
  reaction_6 identity "http://identifiers.org/sbo/SBO:0000029"
  reaction_7 identity "http://identifiers.org/sbo/SBO:0000029"
  reaction_8 identity "http://identifiers.org/sbo/SBO:0000029"
  reaction_9 identity "http://identifiers.org/sbo/SBO:0000029"
  reaction_10 identity "http://identifiers.org/sbo/SBO:0000029"
  reaction_11 identity "http://identifiers.org/sbo/SBO:0000029"
  reaction_12 identity "http://identifiers.org/sbo/SBO:0000012"
  reaction_13 identity "http://identifiers.org/sbo/SBO:0000029"
  reaction_14 identity "http://identifiers.org/sbo/SBO:0000029"
  reaction_15 identity "http://identifiers.org/sbo/SBO:0000029"
  reaction_16 identity "http://identifiers.org/sbo/SBO:0000012"
  reaction_17 identity "http://identifiers.org/sbo/SBO:0000029"
  reaction_18 identity "http://identifiers.org/sbo/SBO:0000012"
  reaction_19 identity "http://identifiers.org/sbo/SBO:0000029"
  reaction_20 identity "http://identifiers.org/sbo/SBO:0000029"
  reaction_21 identity "http://identifiers.org/sbo/SBO:0000029"
  reaction_22 identity "http://identifiers.org/sbo/SBO:0000012"
  reaction_23 identity "http://identifiers.org/sbo/SBO:0000029"
  reaction_24 identity "http://identifiers.org/sbo/SBO:0000029"
  reaction_25 identity "http://identifiers.org/sbo/SBO:0000029"
  reaction_26 identity "http://identifiers.org/sbo/SBO:0000029"
  reaction_27 identity "http://identifiers.org/sbo/SBO:0000029"
  reaction_28 identity "http://identifiers.org/sbo/SBO:0000001"
  reaction_29 identity "http://identifiers.org/sbo/SBO:0000029"
  reaction_30 identity "http://identifiers.org/sbo/SBO:0000029"
end

MODEL1611280000 is "Orton2009 - Modelling cancerous mutations in the EGFR/ERK pathway - EGF Model"

MODEL1611280000 model_entity_is "http://identifiers.org/biomodels.db/MODEL1611280000"
MODEL1611280000 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000623"
MODEL1611280000 description "http://identifiers.org/pubmed/19804630"
MODEL1611280000 origin "http://identifiers.org/biomodels.db/BIOMD0000000033"
MODEL1611280000 hypernym "http://identifiers.org/go/GO:0007173"
MODEL1611280000 taxon "http://identifiers.org/taxonomy/10116"
MODEL1611280000 container "http://identifiers.org/bto/BTO:0001009"
MODEL1611280000 property "http://identifiers.org/doid/DOID:162"
