// Created by libAntimony v2.13.0
model *MODEL1509230010()

  // Compartments and Species:
  compartment VArt, VGut, VGutLumen, VLung, VVen, VRest, VKidney, VLiver;
  compartment VKidneyTubules;
  substanceOnly species CArt in VArt, CGut in VGut, AGutlumen in VGutLumen;
  substanceOnly species CLung in VLung, CVen in VVen, CRest in VRest, CLiver in VLiver;
  substanceOnly species CMetabolized in VLiver, CKidney in VKidney, CTubules in VKidneyTubules;

  // Reactions:
  J1: CArt => CGut; (QGut/VArt)*CArt;
  J2: AGutlumen => CGut; kGutabs*AGutlumen;
  J3: CLung => CArt; (QCardiac/VLung)*CLung;
  J4: CVen => CLung; (QCardiac/VVen)*CVen;
  J5: CArt => CRest; QRest*(CArt/VArt);
  J6: CRest => CVen; (QRest/VRest)*CRest*Ratioblood2plasma/(KRest2plasma*Fraction_unbound_plasma);
  J7: CArt => CLiver; (QLiver/VArt)*CArt;
  J8: CLiver => CMetabolized; CLmetabolism*CLiver/(Kliver2plasma*Fraction_unbound_plasma);
  J9: CGut => CLiver; (QGut/VGut)*CGut;
  J10: CLiver => CVen; ((QLiver + QGut)/VLiver)*CLiver*Ratioblood2plasma/(Kliver2plasma*Fraction_unbound_plasma);
  J11: CArt => CKidney; (QKidney/VArt)*CArt;
  J12: CKidney => CTubules; (Qgfr/VKidney)*CKidney/Kkidney2plasma;
  J13: CKidney => CVen; (QKidney/VKidney)*CKidney*Ratioblood2plasma/(Kkidney2plasma*Fraction_unbound_plasma);

  // Species initializations:
  CArt = 0;
  CArt has substance_per_volume;
  CGut = 0;
  CGut has substance_per_volume;
  AGutlumen = APAP_Dose;
  AGutlumen has substance_per_volume;
  CLung = 0;
  CLung has substance_per_volume;
  CVen = 0;
  CVen has substance_per_volume;
  CRest = 0;
  CRest has substance_per_volume;
  CLiver = 0;
  CLiver has substance_per_volume;
  CMetabolized = 0;
  CMetabolized has substance_per_volume;
  CKidney = 0;
  CKidney has substance_per_volume;
  CTubules = 0;
  CTubules has substance_per_volume;

  // Compartment initializations:
  VArt = VTotal*VArt_fraction_VTotal;
  VArt has volume;
  VGut = VTotal*VGut_fraction_VTotal;
  VGut has volume;
  VGutLumen = 1;
  VGutLumen has volume;
  VLung = VTotal*VLung_fraction_VTotal;
  VLung has volume;
  VVen = VTotal*VVen_fraction_VTotal;
  VVen has volume;
  VRest = VTotal - VArt - VGut - VKidney - VLiver - VLung - VVen;
  VRest has volume;
  VKidney = VTotal*VKidney_fraction_VTotal;
  VKidney has volume;
  VLiver = VTotal*VLiver_fraction_VTotal;
  VLiver has volume;
  VKidneyTubules = 1;
  VKidneyTubules has volume;

  // Variable initializations:
  VTotal = VTotal_ref*(BW/BW_ref);
  VTotal has volume;
  VArt_fraction_VTotal = 0.0357;
  VArt_fraction_VTotal has dimensionless;
  VGut_fraction_VTotal = 0.0263;
  VGut_fraction_VTotal has dimensionless;
  VLung_fraction_VTotal = 0.0121;
  VLung_fraction_VTotal has dimensionless;
  VVen_fraction_VTotal = 0.0812;
  VVen_fraction_VTotal has dimensionless;
  VLiver_fraction_VTotal = 0.0408;
  VLiver_fraction_VTotal has dimensionless;
  VKidney_fraction_VTotal = 0.007;
  VKidney_fraction_VTotal has dimensionless;
  APAP_Dose = APAP_Dose_grams/APAP_MW;
  APAP_Dose has substance;
  APAP_Dose_grams = 1.4;
  APAP_Dose_grams has gram;
  APAP_MW = 151.2;
  APAP_MW has grams2mol;
  BW = 70;
  BW has kilogram;
  BW_ref = 1;
  BW_ref has BW_ref_unit;
  Cardiac_flow_ref = 15;
  Cardiac_flow_ref has Volumetric_Flow;
  QCardiac = Cardiac_flow_ref*(BW/BW_ref)^0.75;
  QCardiac has Volumetric_Flow;
  QGut_fraction_QCardiac = 0.205;
  QGut_fraction_QCardiac has dimensionless;
  QGut = QCardiac*QGut_fraction_QCardiac;
  QGut has Volumetric_Flow;
  QLiver_fraction_QCardiac = 0.0535;
  QLiver_fraction_QCardiac has dimensionless;
  QLiver = QCardiac*QLiver_fraction_QCardiac;
  QLiver has Volumetric_Flow;
  QKidney_fraction_QCardiac = 0.2214;
  QKidney_fraction_QCardiac has dimensionless;
  QKidney = QCardiac*QKidney_fraction_QCardiac;
  QKidney has Volumetric_Flow;
  QRest = QCardiac - QGut - QKidney - QLiver;
  QRest has Volumetric_Flow;
  QGFR_ref = 0.039;
  QGFR_ref has Volumetric_Flow;
  Qgfr = QGFR_ref*(BW/BW_ref)^0.75;
  Qgfr has Volumetric_Flow;
  kGutabs = 1.5;
  kGutabs has first_order_rate_constant;
  CLmetabolism = 9.5;
  CLmetabolism has first_order_rate_constant;
  Fraction_unbound_plasma = 0.8;
  Fraction_unbound_plasma has dimensionless;
  Ratioblood2plasma = 1.09;
  Ratioblood2plasma has dimensionless;
  Kliver2plasma = 1;
  Kliver2plasma has dimensionless;
  Kkidney2plasma = 1;
  Kkidney2plasma has dimensionless;
  KRest2plasma = 1.6;
  KRest2plasma has dimensionless;
  VTotal_ref = 0.6;
  VTotal_ref has volume;

  // Other declarations:
  var VTotal, QCardiac, QGut, QLiver, QKidney, QRest, Qgfr;
  const VArt, VArt_fraction_VTotal, VGut, VGut_fraction_VTotal, VGutLumen;
  const VLung, VLung_fraction_VTotal, VVen, VVen_fraction_VTotal, VRest, VKidney;
  const VLiver, VLiver_fraction_VTotal, VKidney_fraction_VTotal, VKidneyTubules;
  const APAP_Dose, APAP_Dose_grams, APAP_MW, BW, BW_ref, Cardiac_flow_ref;
  const QGut_fraction_QCardiac, QLiver_fraction_QCardiac, QKidney_fraction_QCardiac;
  const QGFR_ref, kGutabs, CLmetabolism, Fraction_unbound_plasma, Ratioblood2plasma;
  const Kliver2plasma, Kkidney2plasma, KRest2plasma, VTotal_ref;

  // Unit definitions:
  unit time_unit = 3600 second;
  unit first_order_rate_constant = 1 / 3600 second;
  unit Volumetric_Flow = litre / 3600 second;
  unit volume = litre;
  unit substance = mole;
  unit grams2mol = gram / mole;
  unit BW_ref_unit = kilogram;
  unit substance_per_volume = mole / litre;

  // Display Names:
  time_unit is "hour";
  volume is "litre";
  substance is "mole";
  BW_ref_unit is "BW_ref";
  J1 is "J01";
  J2 is "J02";
  J3 is "J03";
  J4 is "J04";
  J5 is "J05";
  J6 is "J06";
  J7 is "J07";
  J8 is "J08";
  J9 is "J09";

  // SBO terms:
  VArt.sboTerm = 290
  VTotal.sboTerm = 468
  VArt_fraction_VTotal.sboTerm = 380
  VGut.sboTerm = 290
  VGut_fraction_VTotal.sboTerm = 380
  VGutLumen.sboTerm = 290
  VLung.sboTerm = 290
  VLung_fraction_VTotal.sboTerm = 380
  VVen.sboTerm = 290
  VVen_fraction_VTotal.sboTerm = 380
  VRest.sboTerm = 290
  VKidney.sboTerm = 290
  VLiver.sboTerm = 290
  VLiver_fraction_VTotal.sboTerm = 380
  VKidney_fraction_VTotal.sboTerm = 380
  VKidneyTubules.sboTerm = 290
  CArt.sboTerm = 247
  CGut.sboTerm = 247
  AGutlumen.sboTerm = 247
  APAP_Dose.sboTerm = 2
  CLung.sboTerm = 247
  CVen.sboTerm = 247
  CRest.sboTerm = 247
  CLiver.sboTerm = 247
  CMetabolized.sboTerm = 247
  CKidney.sboTerm = 247
  CTubules.sboTerm = 247
  APAP_Dose_grams.sboTerm = 504
  APAP_MW.sboTerm = 2
  BW.sboTerm = 2
  BW_ref.sboTerm = 381
  Cardiac_flow_ref.sboTerm = 380
  QCardiac.sboTerm = 16
  QGut_fraction_QCardiac.sboTerm = 380
  QGut.sboTerm = 16
  QLiver_fraction_QCardiac.sboTerm = 380
  QLiver.sboTerm = 16
  QKidney_fraction_QCardiac.sboTerm = 380
  QKidney.sboTerm = 16
  QRest.sboTerm = 16
  QGFR_ref.sboTerm = 380
  Qgfr.sboTerm = 16
  kGutabs.sboTerm = 16
  CLmetabolism.sboTerm = 16
  Fraction_unbound_plasma.sboTerm = 470
  Ratioblood2plasma.sboTerm = 470
  Kliver2plasma.sboTerm = 281
  Kkidney2plasma.sboTerm = 281
  KRest2plasma.sboTerm = 281
  VTotal_ref.sboTerm = 380
  J1.sboTerm = 185
  J2.sboTerm = 185
  J3.sboTerm = 185
  J4.sboTerm = 185
  J5.sboTerm = 185
  J6.sboTerm = 185
  J7.sboTerm = 185
  J8.sboTerm = 182
  J9.sboTerm = 185
  J10.sboTerm = 185
  J11.sboTerm = 185
  J12.sboTerm = 185
  J13.sboTerm = 185
end

MODEL1509230010 is "Sluka2016  - Acetaminophen PBPK"

MODEL1509230010.sboTerm = 167

MODEL1509230010 model_entity_is "http://identifiers.org/biomodels.db/MODEL1509230010"
MODEL1509230010 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000619"
MODEL1509230010 description "http://identifiers.org/pubmed/27636091"
MODEL1509230010 origin "http://identifiers.org/pubmed/20421935"
MODEL1509230010 hypernym "http://identifiers.org/go/GO:0042910",
                         "http://identifiers.org/go/GO:0017144"
MODEL1509230010 taxon "http://identifiers.org/taxonomy/9606"
MODEL1509230010 property "http://identifiers.org/mamo/MAMO_0000203"
