// Created by libAntimony v2.13.0
model *MODEL1402200004()

  // Compartments and Species:
  compartment cell, nucleus, membrane, ecm;
  substanceOnly species AcanmRNA in cell, ADAMTS5 in cell, AGEprod in cell;
  substanceOnly species Alk1 in cell, Alk1_Alk5 in cell, Alk5 in cell, Alk5_dimer in cell;
  substanceOnly species Bax in cell, Bax_Bcl2 in cell, Bax_Bcl2_Beclin in cell;
  substanceOnly species Bax_Bcl2_Beclin_I in cell, Bcl2 in cell, Bcl2_Beclin in cell;
  substanceOnly species Bcl2_Beclin_I in cell, Beclin in cell, Beclin_I in cell;
  substanceOnly species Caspase_A in cell, Caspase_I in cell, Col2mRNA in cell;
  substanceOnly species DamP in cell, IkB in cell, IkB_NFkB in cell, IL1 in cell;
  substanceOnly species Lys_A in cell, Lys_I in cell, MMP13 in cell, MMP2 in cell;
  substanceOnly species $NatP in cell, NFkB in cell, NFkB_P in cell, p38 in cell;
  substanceOnly species p38_P in cell, proMMP13 in cell, proMMP2 in cell;
  substanceOnly species RAGE in cell, ROS in cell, Runx2_A in cell, Runx2_I in cell;
  substanceOnly species Smad1 in cell, Smad1_P in cell, Smad1_P_Smad4 in cell;
  substanceOnly species Smad2 in cell, Smad2_P in cell, Smad2_P_Smad4 in cell;
  substanceOnly species Smad4 in cell, Smad7 in cell, SOD in cell, Sox9 in cell;
  substanceOnly species Sox9_A in cell, Sox9mRNA in cell, Tgfb_A in cell;
  substanceOnly species Tgfb_Alk1_Alk5 in cell, Tgfb_Alk1_Alk5_Smad7 in cell;
  substanceOnly species Tgfb_Alk5_dimer in cell, Tgfb_Alk5_dimer_Smad7 in cell;
  substanceOnly species AggFrag in ecm, Aggrecan in ecm, Aggrecan_Collagen2 in ecm;
  substanceOnly species ColFrag in ecm, Collagen2 in ecm, Integrin in ecm;
  substanceOnly species Tgfb_I in ecm, $Sink in cell, $Source in cell, IntegrinCount in ecm;

  // Reactions:
  CaspaseActivation: Caspase_I + Bax => Caspase_A + Bax; kactCasp*Caspase_I*Bax;
  CaspaseActivationByBeclin_I: Caspase_I + Beclin_I => Caspase_A + Beclin_I; kactCaspBecI*Caspase_I*Beclin_I;
  CaspaseActivationBy_p38: Caspase_I + p38_P => Caspase_A + p38_P; kactCaspp38*Caspase_I*p38_P;
  CaspaseInactivation1: Caspase_A => Caspase_I; kinactCasp*Caspase_A;
  InhibitCaspase2: Caspase_A + Bcl2_Beclin => Caspase_I + Bcl2_Beclin; kinactCaspBcl2*Caspase_A*Bcl2_Beclin;
  InhibitCaspase3: Caspase_A + Bcl2 => Caspase_I + Bcl2; kinactCaspBcl2*Caspase_A*Bcl2;
  ActivateLysosome: Lys_I + Beclin => Lys_A + Beclin; kactLys*Lys_I*Beclin;
  InhibitLysosome: Lys_A => Lys_I; kinhibLys*Lys_A;
  Bcl2Synthesis: $Source => Bcl2; ksynBcl2*Source;
  Bcl2Degradation: Bcl2 => $Sink; kdegBcl2*Bcl2;
  Bcl2DegradationStressInduced: Bcl2 + ROS => $Sink + ROS; kdegBcl2ROS*Bcl2*ROS;
  Bcl2DegradationCaspaseInduced: Bcl2 + Caspase_A => $Sink + Caspase_A; kdegBcl2Casp*Bcl2*Caspase_A;
  Bax_Bcl2Binding: Bax + Bcl2 => Bax_Bcl2; kbinBaxBcl2*Bax*Bcl2;
  Bax_Bcl2Release: Bax_Bcl2 => Bax + Bcl2; krelBaxBcl2*Bax_Bcl2;
  Bcl2_BeclinBinding: Bcl2 + Beclin => Bcl2_Beclin; kbinBcl2Beclin*Bcl2*Beclin;
  Bcl2_BeclinRelease: Bcl2_Beclin => Bcl2 + Beclin; krelBcl2Beclin*Bcl2_Beclin;
  Bcl2_Beclin_I_Binding: Bcl2 + Beclin_I => Bcl2_Beclin_I; kbinBcl2Beclin*Bcl2*Beclin_I;
  Bcl2_Beclin_I_Release: Bcl2_Beclin_I => Bcl2 + Beclin_I; krelBcl2Beclin*Bcl2_Beclin_I;
  BeclinInactivation: Beclin => Beclin_I; kinactBec*Beclin;
  BeclinInactivationByCaspase: Beclin + Caspase_A => Beclin_I + Caspase_A; kinactBecCasp*Beclin*Caspase_A;
  BeclinBindingToBax_Bcl2: Beclin + Bax_Bcl2 => Bax_Bcl2_Beclin; kbinBecToBaxBcl2*Beclin*Bax_Bcl2;
  BeclinIBindingToBax_Bcl2: Beclin_I + Bax_Bcl2 => Bax_Bcl2_Beclin_I; kbinBecToBaxBcl2*Beclin_I*Bax_Bcl2;
  BaxBindingToBcl2_Beclin: Bax + Bcl2_Beclin => Bax_Bcl2_Beclin; kbinBaxToBcl2Bec*Bax*Bcl2_Beclin;
  BaxBindingToBcl2_BeclinI: Bax + Bcl2_Beclin_I => Bax_Bcl2_Beclin_I; kbinBaxToBcl2Bec*Bax*Bcl2_Beclin_I;
  BaxDissociation_Bax_Bcl2_Beclin: Bax_Bcl2_Beclin => Bax + Bcl2_Beclin; krelBaxBcl2Bec*Bax_Bcl2_Beclin;
  BaxDissociation_Bax_Bcl2_Beclin_I: Bax_Bcl2_Beclin_I => Bax + Bcl2_Beclin_I; krelBaxBcl2Bec*Bax_Bcl2_Beclin_I;
  BeclinDissociation_Bax_Bcl2_Beclin: Bax_Bcl2_Beclin => Beclin + Bax_Bcl2; krelBecBaxBcl2*Bax_Bcl2_Beclin;
  Beclin_I_Dissociation_Bax_Bcl2_Beclin: Bax_Bcl2_Beclin_I => Beclin_I + Bax_Bcl2; krelBecBaxBcl2*Bax_Bcl2_Beclin_I;
  ROS_generation: $Source => ROS; kgenROS*Source;
  ROS_removal: ROS => $Sink; kremROS*ROS;
  Protein_Damage_by_ROS: $NatP + ROS => DamP + ROS; kdamNatP*NatP*ROS/(10 + ROS);
  Removal_DamP_by_Autophagy: DamP + Lys_A => Lys_A; kdegDamP*DamP*Lys_A;
  Production_of_AGEproducts: $Source => AGEprod; kprodAGE*Source;
  RAGE_activation: AGEprod => AGEprod + RAGE; kactRAGE*AGEprod;
  ROS_production_by_RAGE: RAGE => RAGE + ROS; kgenROSbyRAGE*RAGE;
  IkB_degradation_via_ROS: ROS + IkB_NFkB => ROS + NFkB; kdegIkB*ROS*IkB_NFkB;
  IkB_degradation_via_IL1: IL1 + IkB_NFkB => IL1 + NFkB; kdegIkB*IL1*IkB_NFkB;
  NFkB_inactivation: NFkB + IkB => IkB_NFkB; kinactNFkB*NFkB*IkB;
  RAGE_inactivation: RAGE => $Sink; kinactRAGE*RAGE;
  RAGE_upregulation_byNFkB: NFkB_P => NFkB_P + RAGE; ksynRAGE*NFkB_P;
  IL1_production: NFkB_P => NFkB_P + IL1; ksynIL1*NFkB_P;
  IL1_degradation: IL1 => $Sink; kdegIL1*IL1;
  IkB_production: NFkB_P => NFkB_P + IkB; ksynIkB*NFkB_P;
  MMP13_production: IL1 => IL1 + proMMP13; ksynMMP13*IL1;
  MMP13_removal: MMP13 => $Sink; kdegMMP13*MMP13;
  MMP2_production: IL1 => IL1 + proMMP2; ksynMMP2*IL1;
  MMP_activation: proMMP2 => MMP2; kactMMP2*proMMP2;
  MMP2_degradation: MMP2 => $Sink; kdegMMP2*MMP2;
  ADAMTS5_production: IL1 => IL1 + ADAMTS5; ksynADAMTS5*IL1;
  ADAMTS5_removal: ADAMTS5 => $Sink; kdegADAMTS5*ADAMTS5;
  Aggrecan_degradation: Aggrecan_Collagen2 + ADAMTS5 => Collagen2 + ADAMTS5 + AggFrag; kdegAggrecan*Aggrecan_Collagen2*ADAMTS5;
  Collagen_degradation: Collagen2 + MMP13 => MMP13 + ColFrag; kdegCollagen*Collagen2*MMP13;
  ROS_production_by_DamP: DamP => DamP + ROS; kgenROSbyDamP*DamP;
  Protein_synthesis: $Source => $NatP; ksynNatP*Source;
  SOD_synthesis: NFkB_P => NFkB_P + SOD; ksynSOD*NFkB_P;
  SOD_degradation: SOD => $Sink; kdegSOD*SOD;
  ROS_removal_by_SOD: ROS + SOD => SOD; kremROSbySOD*SOD*ROS;
  p38_phosphorylation: p38 + IL1 => p38_P + IL1; kphosp38*p38*IL1;
  p38_phosphorylation_via_ROS: p38 + ROS => p38_P + ROS; kphosp38ROS*p38*ROS;
  p38_dephosphorylation: p38_P => p38; kdephosp38*p38_P;
  NFkB_activation: NFkB + p38_P => NFkB_P + p38_P; kphosNFkB*NFkB*p38_P;
  NFkB_dephosphorylation: NFkB_P => NFkB; kdephosNFkB*NFkB_P;
  ROS_production_by_p38_P: p38_P => p38_P + ROS; kgenROSbyp38*p38_P;
  Lysosome_damage_by_ROS: Lys_A + ROS => Lys_I + ROS; kdamLys*Lys_A*ROS/(10 + ROS);
  IntegrinActivationByMechanicalStress: $Source => Integrin + IntegrinCount; kactIntegrin*Source;
  IntegrinInactivation: Integrin => $Sink; kinactIntegrin*Integrin;
  Alk5Synthesis: $Source => Alk5; ksynAlk5*Source;
  TgfbActivationByIntegrin: Tgfb_I + Integrin => Tgfb_A + Integrin; kactTgfbIntegrin*Tgfb_I*Integrin;
  TgfbActivationByMMP2: Tgfb_I + MMP2 => Tgfb_A + MMP2; kactTgfbMMP2*Tgfb_I*MMP2;
  TgfbInactivation: Tgfb_A => Tgfb_I; kinactTgfb*Tgfb_A;
  Alk5Dimerisation: 2 Alk5 => Alk5_dimer; kdimerAlk5*Alk5*(Alk5 - 1)*0.5;
  Alk5Dedimerisation: Alk5_dimer => 2 Alk5; kdedimerAlk5*Alk5_dimer;
  Alk1Alk5Binding: Alk1 + Alk5 => Alk1_Alk5; kbinAlk1Alk5*Alk1*Alk5;
  Alk1Alk5Release: Alk1_Alk5 => Alk1 + Alk5; krelAlk1Alk5*Alk1_Alk5;
  TgfbReceptorBindingAlk5: Tgfb_A + Alk5_dimer => Tgfb_Alk5_dimer; kbinTgfbAlk5*Tgfb_A*Alk5_dimer;
  TgfbReceptorRelease: Tgfb_Alk5_dimer => Tgfb_A + Alk5_dimer; krelTgfbAlk5*Tgfb_Alk5_dimer;
  Tgfb_Alk5_BindingSmad7: Tgfb_Alk5_dimer + Smad7 => Tgfb_Alk5_dimer_Smad7; kbinSmad7Alk5*Tgfb_Alk5_dimer*Smad7;
  Tgfb_Alk5_Smad7Release: Tgfb_Alk5_dimer_Smad7 => Tgfb_Alk5_dimer + Smad7; krelSmad7Alk5*Tgfb_Alk5_dimer_Smad7;
  Alk5_Smad7Degradation: Tgfb_Alk5_dimer_Smad7 => Tgfb_I; kdegSmad7Alk5*Tgfb_Alk5_dimer_Smad7;
  TgfbReceptorBindingAlk1: Tgfb_A + Alk1_Alk5 => Tgfb_Alk1_Alk5; kbinTgfbAlk1*Tgfb_A*Alk1_Alk5;
  TgfbAlk1Release: Tgfb_Alk1_Alk5 => Tgfb_A + Alk1_Alk5; krelTgfbAlk1*Tgfb_Alk1_Alk5;
  Smad2Phosphorylation: Tgfb_Alk5_dimer + Smad2 => Tgfb_Alk5_dimer + Smad2_P; kphosSmad2*Tgfb_Alk5_dimer*Smad2;
  Smad2Smad4Binding: Smad2_P + Smad4 => Smad2_P_Smad4; kbinSmad2Smad4*Smad2_P*Smad4;
  Smad2PSmad4Release: Smad2_P_Smad4 => Smad2_P + Smad4; krelSmad2Smad4*Smad2_P_Smad4;
  Smad2DephosphorylationNuc: Smad2_P => Smad2; kdephosSmad2*Smad2_P;
  Smad7Synthesis: Smad2_P_Smad4 => Smad2_P_Smad4 + Smad7; ksynSmad7*Smad2_P_Smad4;
  Sox9Activation: Smad2_P_Smad4 + Sox9 => Smad2_P_Smad4 + Sox9_A; kactSox9*Smad2_P_Smad4*Sox9;
  Sox9Inactivation: Sox9_A => Sox9; kinactSox9*Sox9_A;
  Sox9BasalTranscription: $Source => Sox9mRNA; ksynSox9mRNA*Source;
  Sox9EnhancedTranscription: Sox9_A => Sox9_A + Sox9mRNA; ksynSox9mRNASox9A*Sox9_A;
  Sox9mRNA_Degradation: Sox9mRNA => $Sink; kdegSox9mRNA*Sox9mRNA;
  Sox9Translation: Sox9mRNA => Sox9mRNA + Sox9; ksynSox9*Sox9mRNA;
  Sox9Degradation: Sox9 => $Sink; kdegSox9*Sox9;
  Collagen2EnhancedTranscriptionBySox9: Sox9_A => Sox9_A + Col2mRNA; ksynCol2mRNASox9A*Sox9_A;
  Collagen2TranscriptionBySmad2Smad4: Smad2_P_Smad4 => Smad2_P_Smad4 + Col2mRNA; ksynCol2mRNASmad*Smad2_P_Smad4;
  Col2mRNA_Degradation: Col2mRNA => $Sink; kdegCol2mRNA*Col2mRNA;
  Collagen2Translation: Col2mRNA => Col2mRNA + Collagen2; ksynCol2*Col2mRNA;
  AggrecanEnhancedTranscription: Sox9_A => Sox9_A + AcanmRNA; ksynAcanmRNASox9A*Sox9_A;
  AcanmRNA_Degradation: AcanmRNA => $Sink; kdegAcanmRNA*AcanmRNA;
  AggrecanTranslation: AcanmRNA => AcanmRNA + Aggrecan; ksynAggrecan*AcanmRNA;
  AggrecanCollagen2Binding: Aggrecan + Collagen2 => Aggrecan_Collagen2; kbinAggrecanCollagen2*Aggrecan*Collagen2;
  Runx2_InhibitionBySmad2: Runx2_A + Smad2_P_Smad4 => Runx2_I + Smad2_P_Smad4; kinactRunx2*Runx2_A*Smad2_P_Smad4;
  Alk5Degradation: Alk5 => $Sink; kdegAlk5*Alk5;
  Smad1Activation: Tgfb_Alk1_Alk5 + Smad1 => Tgfb_Alk1_Alk5 + Smad1_P; kphosSmad1*Tgfb_Alk1_Alk5*Smad1;
  Smad1Dephosphorylation: Smad1_P => Smad1; kdephosSmad1*Smad1_P;
  Smad1DephosphorylationViaSmad7: Smad1_P + Smad7 => Smad1 + Smad7; kdephosSmad1Smad7*Smad1_P*Smad7;
  Smad1Smad4Binding: Smad1_P + Smad4 => Smad1_P_Smad4; kbinSmad1Smad4*Smad1_P*Smad4;
  Smad1Smad4Release: Smad1_P_Smad4 => Smad1_P + Smad4; krelSmad1Smad4*Smad1_P_Smad4;
  Runx2ActivationBySmad1: Runx2_I + Smad1_P_Smad4 => Runx2_A + Smad1_P_Smad4; kactRunx2*Runx2_I*Smad1_P_Smad4;
  MMP13InductionByRunx2: Runx2_A => proMMP13 + Runx2_A; ksynMMP13Runx2*Runx2_A;
  Alk1Synthesis: $Source => Alk1; ksynAlk1*Source;
  Alk1Degradation: Alk1 => $Sink; kdegAlk1*Alk1;
  MMP13Activation: proMMP13 => MMP13; kactMMP13*proMMP13;
  Tgfb_Alk1_Alk5_BindingSmad7: Tgfb_Alk1_Alk5 + Smad7 => Tgfb_Alk1_Alk5_Smad7; kbinSmad7Alk1*Tgfb_Alk1_Alk5*Smad7;
  Tgfb_Alk1_Alk5_Smad7Release: Tgfb_Alk1_Alk5_Smad7 => Tgfb_Alk1_Alk5 + Smad7; krelSmad7Alk1*Tgfb_Alk1_Alk5_Smad7;
  Alk1_Smad7Degradation: Tgfb_Alk1_Alk5_Smad7 => Tgfb_I; kdegSmad7Alk1*Tgfb_Alk1_Alk5_Smad7;
  Smad7Degradation: Smad7 => $Sink; kdegSmad7*Smad7;

  // Species initializations:
  AcanmRNA = 0;
  ADAMTS5 = 0;
  AGEprod = 0;
  Alk1 = 500/cell;
  Alk1_Alk5 = 0;
  Alk5 = 500/cell;
  Alk5_dimer = 0;
  Bax = 0;
  Bax_Bcl2 = 90/cell;
  Bax_Bcl2_Beclin = 10/cell;
  Bax_Bcl2_Beclin_I = 0;
  Bcl2 = 30/cell;
  Bcl2_Beclin = 25/cell;
  Bcl2_Beclin_I = 0;
  Beclin = 75/cell;
  Beclin_I = 0;
  Caspase_A = 0;
  Caspase_I = 100/cell;
  Col2mRNA = 0;
  DamP = 0;
  IkB = 0;
  IkB_NFkB = 100/cell;
  IL1 = 0;
  Lys_A = 40/cell;
  Lys_I = 360/cell;
  MMP13 = 0;
  MMP2 = 0;
  NatP = 1500/cell;
  NFkB = 0;
  NFkB_P = 0;
  p38 = 100/cell;
  p38_P = 0;
  proMMP13 = 0;
  proMMP2 = 0;
  RAGE = 0;
  ROS = 2/cell;
  Runx2_A = 0;
  Runx2_I = 100/cell;
  Smad1 = 600/cell;
  Smad1_P = 0;
  Smad1_P_Smad4 = 0;
  Smad2 = 600/cell;
  Smad2_P = 0;
  Smad2_P_Smad4 = 0;
  Smad4 = 600/cell;
  Smad7 = 0;
  SOD = 2/cell;
  Sox9 = 100/cell;
  Sox9_A = 0;
  Sox9mRNA = 10/cell;
  Tgfb_A = 0;
  Tgfb_Alk1_Alk5 = 0;
  Tgfb_Alk1_Alk5_Smad7 = 0;
  Tgfb_Alk5_dimer = 0;
  Tgfb_Alk5_dimer_Smad7 = 0;
  AggFrag = 0;
  Aggrecan = 0;
  Aggrecan_Collagen2 = 1000/ecm;
  ColFrag = 0;
  Collagen2 = 0;
  Integrin = 0;
  Tgfb_I = 200/ecm;
  Sink = 0;
  Source = 1/cell;
  IntegrinCount = 0;

  // Compartment initializations:
  cell = 1;
  nucleus = 1;
  membrane = 1;
  ecm = 1;

  // Variable initializations:
  kactCasp = 1e-07;
  kactCaspBecI = 8.3e-07;
  kactCaspp38 = 8e-07;
  kactIntegrin = 4e-07;
  kactLys = 1e-08;
  kactMMP13 = 0.0001;
  kactMMP2 = 1e-07;
  kactNFkB = 0.0001;
  kactRAGE = 0.001;
  kactRunx2 = 0.001;
  kactSox9 = 5e-06;
  kactTgfbIntegrin = 0.001;
  kactTgfbMMP2 = 1e-07;
  kbinAggrecanCollagen2 = 0.0001;
  kbinAlk1Alk5 = 5e-05;
  kbinBaxBcl2 = 1.67;
  kbinBaxToBcl2Bec = 0.000167;
  kbinBcl2Beclin = 7.5e-05;
  kbinBecToBaxBcl2 = 1.67e-05;
  kbinSmad1Smad4 = 5e-05;
  kbinSmad2Smad4 = 0.0001;
  kbinSmad7Alk1 = 0.5;
  kbinSmad7Alk5 = 2e-05;
  kbinTgfbAlk1 = 2e-05;
  kbinTgfbAlk5 = 3e-05;
  kdamLys = 5e-06;
  kdamNatP = 8e-06;
  kdedimerAlk5 = 0.001;
  kdegAcanmRNA = 9e-06;
  kdegADAMTS5 = 5e-05;
  kdegAggrecan = 1e-09;
  kdegAlk1 = 1.2e-08;
  kdegAlk5 = 4e-07;
  kdegBcl2 = 0.000167;
  kdegBcl2Casp = 0.00167;
  kdegBcl2ROS = 0.00167;
  kdegCol2mRNA = 1.07e-05;
  kdegCollagen = 1e-08;
  kdegDamP = 4e-05;
  kdegIkB = 1e-06;
  kdegIL1 = 0.005;
  kdegMMP13 = 6.4e-06;
  kdegMMP2 = 6.4e-06;
  kdegSmad7 = 0.005;
  kdegSmad7Alk1 = 5e-06;
  kdegSmad7Alk5 = 1e-05;
  kdegSOD = 0.001;
  kdegSox9 = 4.8e-05;
  kdegSox9mRNA = 0.0001;
  kdegTgfb = 0.00578;
  kdephosNFkB = 0.01;
  kdephosp38 = 0.01;
  kdephosSmad1 = 0.0005;
  kdephosSmad1Smad7 = 0.0006;
  kdephosSmad2 = 0.006;
  kdimerAlk5 = 0.0002;
  kgenROS = 0.0005;
  kgenROSbyDamP = 0.0001;
  kgenROSbyp38 = 0.0001;
  kgenROSbyRAGE = 0.0004;
  kinactBec = 5e-10;
  kinactBecCasp = 1e-08;
  kinactCasp = 0.0003;
  kinactCaspBcl2 = 0.0003;
  kinactIntegrin = 0.0005;
  kinactNFkB = 0.1;
  kinactRAGE = 0.001;
  kinactRunx2 = 0.0005;
  kinactSox9 = 0.0015;
  kinactTgfb = 0.05;
  kinhibLys = 7e-06;
  kphosNFkB = 0.001;
  kphosp38 = 1e-07;
  kphosp38ROS = 0.0001;
  kphosSmad1 = 2e-05;
  kphosSmad2 = 4e-05;
  kprodAGE = 1e-06;
  krelAlk1Alk5 = 0.01;
  krelBaxBcl2 = 0.00167;
  krelBaxBcl2Bec = 0.00167;
  krelBcl2Beclin = 0.0005;
  krelBecBaxBcl2 = 0.0167;
  krelSmad1Smad4 = 0.0167;
  krelSmad2Smad4 = 0.0167;
  krelSmad7Alk1 = 0.001;
  krelSmad7Alk5 = 1e-06;
  krelTgfbAlk1 = 1e-06;
  krelTgfbAlk5 = 1e-06;
  kremROS = 0.000383;
  kremROSbySOD = 0.0001;
  ksynAcanmRNA = 0;
  ksynAcanmRNASox9A = 4.6e-06;
  ksynADAMTS5 = 0.0005;
  ksynAggrecan = 1e-06;
  ksynAlk1 = 5e-06;
  ksynAlk5 = 5e-06;
  ksynBcl2 = 0.002;
  ksynCol2 = 1e-07;
  ksynCol2mRNA = 0;
  ksynCol2mRNASmad = 1e-06;
  ksynCol2mRNASox9A = 1e-06;
  ksynIkB = 0.001;
  ksynIL1 = 0.005;
  ksynMMP13 = 3.2e-05;
  ksynMMP13Runx2 = 1.5e-06;
  ksynMMP2 = 5e-06;
  ksynNatP = 0;
  ksynRAGE = 0.0001;
  ksynSmad7 = 1e-05;
  ksynSOD = 0.002;
  ksynSox9 = 0.00048;
  ksynSox9mRNA = 1e-05;
  ksynSox9mRNASox9A = 5e-06;

  // Other declarations:
  const cell, nucleus, membrane, ecm, kactCasp, kactCaspBecI, kactCaspp38;
  const kactIntegrin, kactLys, kactMMP13, kactMMP2, kactNFkB, kactRAGE, kactRunx2;
  const kactSox9, kactTgfbIntegrin, kactTgfbMMP2, kbinAggrecanCollagen2, kbinAlk1Alk5;
  const kbinBaxBcl2, kbinBaxToBcl2Bec, kbinBcl2Beclin, kbinBecToBaxBcl2, kbinSmad1Smad4;
  const kbinSmad2Smad4, kbinSmad7Alk1, kbinSmad7Alk5, kbinTgfbAlk1, kbinTgfbAlk5;
  const kdamLys, kdamNatP, kdedimerAlk5, kdegAcanmRNA, kdegADAMTS5, kdegAggrecan;
  const kdegAlk1, kdegAlk5, kdegBcl2, kdegBcl2Casp, kdegBcl2ROS, kdegCol2mRNA;
  const kdegCollagen, kdegDamP, kdegIkB, kdegIL1, kdegMMP13, kdegMMP2, kdegSmad7;
  const kdegSmad7Alk1, kdegSmad7Alk5, kdegSOD, kdegSox9, kdegSox9mRNA, kdegTgfb;
  const kdephosNFkB, kdephosp38, kdephosSmad1, kdephosSmad1Smad7, kdephosSmad2;
  const kdimerAlk5, kgenROS, kgenROSbyDamP, kgenROSbyp38, kgenROSbyRAGE, kinactBec;
  const kinactBecCasp, kinactCasp, kinactCaspBcl2, kinactIntegrin, kinactNFkB;
  const kinactRAGE, kinactRunx2, kinactSox9, kinactTgfb, kinhibLys, kphosNFkB;
  const kphosp38, kphosp38ROS, kphosSmad1, kphosSmad2, kprodAGE, krelAlk1Alk5;
  const krelBaxBcl2, krelBaxBcl2Bec, krelBcl2Beclin, krelBecBaxBcl2, krelSmad1Smad4;
  const krelSmad2Smad4, krelSmad7Alk1, krelSmad7Alk5, krelTgfbAlk1, krelTgfbAlk5;
  const kremROS, kremROSbySOD, ksynAcanmRNA, ksynAcanmRNASox9A, ksynADAMTS5;
  const ksynAggrecan, ksynAlk1, ksynAlk5, ksynBcl2, ksynCol2, ksynCol2mRNA;
  const ksynCol2mRNASmad, ksynCol2mRNASox9A, ksynIkB, ksynIL1, ksynMMP13;
  const ksynMMP13Runx2, ksynMMP2, ksynNatP, ksynRAGE, ksynSmad7, ksynSOD;
  const ksynSox9, ksynSox9mRNA, ksynSox9mRNASox9A;

  // Unit definitions:
  unit substance = item;

  // SBO terms:
  Alk5_dimer.sboTerm = 607
  Sink.sboTerm = 291
  Source.sboTerm = 291

  // CV terms:
  cell hypernym "http://identifiers.org/go/GO:0005623"
  nucleus hypernym "http://identifiers.org/go/GO:0005634"
  membrane hypernym "http://identifiers.org/go/GO:0016020"
  ecm hypernym "http://identifiers.org/go/GO:0065010"
  AcanmRNA hypernym "http://identifiers.org/uniprot/P16112"
  ADAMTS5 hypernym "http://identifiers.org/uniprot/Q9UNA0"
  Alk1 hypernym "http://identifiers.org/uniprot/P37023"
  Alk1_Alk5 part "http://identifiers.org/uniprot/P37023",
                 "http://identifiers.org/uniprot/P36897"
  Alk5 hypernym "http://identifiers.org/uniprot/P36897"
  Alk5_dimer hypernym "http://identifiers.org/uniprot/P36897"
  Bax hypernym "http://identifiers.org/uniprot/Q07812"
  Bax_Bcl2 part "http://identifiers.org/uniprot/Q07812",
                "http://identifiers.org/uniprot/P10415"
  Bax_Bcl2_Beclin part "http://identifiers.org/uniprot/Q07812",
                       "http://identifiers.org/uniprot/P10415",
                       "http://identifiers.org/uniprot/Q14457"
  Bax_Bcl2_Beclin_I part "http://identifiers.org/uniprot/Q07812",
                         "http://identifiers.org/uniprot/P10415",
                         "http://identifiers.org/uniprot/Q14457"
  Bcl2 hypernym "http://identifiers.org/uniprot/P10415"
  Bcl2_Beclin part "http://identifiers.org/uniprot/P10415",
                   "http://identifiers.org/uniprot/Q14457"
  Bcl2_Beclin_I part "http://identifiers.org/uniprot/P10415",
                     "http://identifiers.org/uniprot/Q14457"
  Beclin hypernym "http://identifiers.org/uniprot/Q14457"
  Beclin_I hypernym "http://identifiers.org/uniprot/Q14457"
  Caspase_A hypernym "http://identifiers.org/uniprot/P42574"
  Caspase_I hypernym "http://identifiers.org/uniprot/P42574"
  Col2mRNA hypernym "http://identifiers.org/uniprot/P02458"
  IkB hypernym "http://identifiers.org/uniprot/P25963"
  IkB_NFkB part "http://identifiers.org/uniprot/P25963",
                "http://identifiers.org/uniprot/Q04206"
  IL1 hypernym "http://identifiers.org/uniprot/P01583"
  Lys_A hypernym "http://identifiers.org/go/GO:0005764"
  Lys_I hypernym "http://identifiers.org/go/GO:0005764"
  MMP13 hypernym "http://identifiers.org/uniprot/P45452"
  MMP2 hypernym "http://identifiers.org/uniprot/P08253"
  NFkB hypernym "http://identifiers.org/uniprot/Q04206"
  NFkB_P hypernym "http://identifiers.org/uniprot/Q04206"
  NFkB_P identity "http://identifiers.org/pr/PR:000037070"
  p38 hypernym "http://identifiers.org/uniprot/Q16539"
  p38_P hypernym "http://identifiers.org/uniprot/Q16539"
  p38_P identity "http://identifiers.org/pr/PR:000037070"
  proMMP13 hypernym "http://identifiers.org/uniprot/P45452"
  proMMP2 hypernym "http://identifiers.org/uniprot/P08253"
  RAGE hypernym "http://identifiers.org/uniprot/Q15109"
  ROS hypernym "http://identifiers.org/chebi/CHEBI:26523"
  Runx2_A hypernym "http://identifiers.org/uniprot/Q13950"
  Runx2_I hypernym "http://identifiers.org/uniprot/Q13950"
  Smad1 hypernym "http://identifiers.org/uniprot/Q15797"
  Smad1_P hypernym "http://identifiers.org/uniprot/Q15797"
  Smad1_P identity "http://identifiers.org/pr/PR:000037070"
  Smad1_P_Smad4 part "http://identifiers.org/uniprot/Q15797",
                     "http://identifiers.org/uniprot/Q13485"
  Smad1_P_Smad4 identity "http://identifiers.org/pr/PR:000037070"
  Smad2 hypernym "http://identifiers.org/uniprot/Q15796"
  Smad2_P hypernym "http://identifiers.org/uniprot/Q15796"
  Smad2_P identity "http://identifiers.org/pr/PR:000037070"
  Smad2_P_Smad4 part "http://identifiers.org/uniprot/Q15796",
                     "http://identifiers.org/uniprot/Q13485"
  Smad2_P_Smad4 identity "http://identifiers.org/pr/PR:000037070"
  Smad4 hypernym "http://identifiers.org/uniprot/Q13485"
  Smad7 hypernym "http://identifiers.org/uniprot/O15105"
  SOD hypernym "http://identifiers.org/uniprot/P00441"
  Sox9 hypernym "http://identifiers.org/uniprot/P48436"
  Sox9_A hypernym "http://identifiers.org/uniprot/P48436"
  Sox9mRNA encodement "http://identifiers.org/uniprot/P48436"
  Tgfb_A hypernym "http://identifiers.org/uniprot/P01137"
  Tgfb_Alk1_Alk5 part "http://identifiers.org/uniprot/P01137",
                      "http://identifiers.org/uniprot/P37023",
                      "http://identifiers.org/uniprot/P36897",
                      "http://identifiers.org/uniprot/O15105"
  Tgfb_Alk1_Alk5_Smad7 part "http://identifiers.org/uniprot/P01137",
                            "http://identifiers.org/uniprot/P37023",
                            "http://identifiers.org/uniprot/P36897",
                            "http://identifiers.org/uniprot/O15105"
  Tgfb_Alk5_dimer part "http://identifiers.org/uniprot/P01137",
                       "http://identifiers.org/uniprot/P36897"
  Tgfb_Alk5_dimer_Smad7 part "http://identifiers.org/uniprot/P01137",
                             "http://identifiers.org/uniprot/P36897",
                             "http://identifiers.org/uniprot/O15105"
  AggFrag hypernym "http://identifiers.org/uniprot/P16112"
  AggFrag property "http://identifiers.org/pato/PATO:0001444"
  Aggrecan hypernym "http://identifiers.org/uniprot/P16112"
  Aggrecan_Collagen2 part "http://identifiers.org/uniprot/P16112",
                          "http://identifiers.org/uniprot/P02458"
  ColFrag hypernym "http://identifiers.org/uniprot/P02458"
  ColFrag property "http://identifiers.org/pato/PATO:0001444"
  Collagen2 hypernym "http://identifiers.org/uniprot/P02458"
  Integrin hypernym "http://identifiers.org/go/GO:0008305"
  Tgfb_I hypernym "http://identifiers.org/uniprot/P01137"
  IntegrinCount hypernym "http://identifiers.org/go/GO:0008305"
  IntegrinCount identity "http://identifiers.org/pato/PATO:0000070"
end

MODEL1402200004 is "Hui2016 - Age-related changes in articular cartilage"

MODEL1402200004 model_entity_is "http://identifiers.org/biomodels.db/MODEL1402200004"
MODEL1402200004 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000560"
MODEL1402200004 description "http://identifiers.org/pubmed/25475114"
MODEL1402200004 property "http://identifiers.org/doid/DOID:8398"
MODEL1402200004 hypernym "http://identifiers.org/go/GO:0001322",
                         "http://identifiers.org/go/GO:0051216"
MODEL1402200004 taxon "http://identifiers.org/taxonomy/10090"
MODEL1402200004 container "http://identifiers.org/fma/FMA:35175"
