// Created by libAntimony v2.13.0
function Constant_flux__irreversible(v)
  v;
end

Constant_flux__irreversible is "Constant flux (irreversible)"

function Loss_of_intracellular_choline_0(k1, a, b)
  k1*a*b;
end

Loss_of_intracellular_choline_0 is "Loss of intracellular choline"

function Effect_of_extracellular_ACh_0(k3, a)
  k3*a;
end

Effect_of_extracellular_ACh_0 is "Effect of extracellular ACh"

function Decrease_in_the_extracellular_concentration_of_beta_amyloid_0(k4, b)
  k4*b;
end

Decrease_in_the_extracellular_concentration_of_beta_amyloid_0 is "Decrease in the extracellular concentration of beta-amyloid"


model *MODEL1410200000()

  // Compartments and Species:
  compartment Brain;
  species a in Brain, b in Brain, $aRel in Brain;

  // Assignment Rules:
  aRel := a/50;

  // Reactions:
  Loss_of_intracellular_choline: a => ; Brain*Loss_of_intracellular_choline_0(k1, a, b);
  Abeta_formation_from_APP:  => b; Brain*Constant_flux__irreversible(k2);
  Effect_of_extracellular_ACh: b => ; Brain*Effect_of_extracellular_ACh_0(k3, a);
  Decrease_in_the_extracellular_concentration_of_beta_amyloid: b => ; Brain*Decrease_in_the_extracellular_concentration_of_beta_amyloid_0(k4, b);

  // Species initializations:
  a = 50;
  b = 0;

  // Compartment initializations:
  Brain = 1;

  // Variable initializations:
  k1 = 0.007;
  k2 = 0.33;
  k3 = 0.0042;
  k4 = 0.01;

  // Other declarations:
  const Brain, k1, k2, k3, k4;

  // Unit definitions:
  unit volume = 1e-3 litre;
  unit time_unit = 86400 second;
  unit substance = 1e-3 mole;

  // Display Names:
  time_unit is "time";
  Loss_of_intracellular_choline is "Loss of intracellular choline";
  Abeta_formation_from_APP is "Abeta formation from APP";
  Effect_of_extracellular_ACh is "Effect of extracellular ACh";
  Decrease_in_the_extracellular_concentration_of_beta_amyloid is "Decrease in the extracellular concentration of beta-amyloid";

  // CV terms:
  Brain identity "http://identifiers.org/bto/BTO:0000142"
  a identity "http://identifiers.org/chebi/CHEBI:15355"
  b identity "http://identifiers.org/uniprot/P05067"
  aRel identity "http://identifiers.org/chebi/CHEBI:15355"
end

MODEL1410200000 is "Ehrenstein1997 - The choline-leakage hypothesis in Alzheimer's disease"

MODEL1410200000 model_entity_is "http://identifiers.org/biomodels.db/MODEL1410200000"
MODEL1410200000 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000553"
MODEL1410200000 description "http://identifiers.org/pubmed/9284295"
MODEL1410200000 taxon "http://identifiers.org/taxonomy/9606"
MODEL1410200000 hypernym "http://identifiers.org/go/GO:0008292"
MODEL1410200000 version "http://identifiers.org/doid/DOID:10652"
