// Created by libAntimony v2.13.0
model *MODEL1407230000()

  // Compartments and Species:
  compartment Hypctol;
  species COP1 in Hypctol, HY5 in Hypctol, $FHY3 in Hypctol, DWD in Hypctol;
  species CDW in Hypctol;
  substanceOnly species CS in Hypctol, CD in Hypctol, CDCS in Hypctol, UVR8M in Hypctol;
  substanceOnly species UCS in Hypctol, UVR8D in Hypctol, RUP in Hypctol;
  substanceOnly species UR in Hypctol, UVR8_M in Hypctol;

  // Assignment Rules:
  UM_Total := 2*UCS + UVR8M + UR;
  COP1_Total := 2*UCS + 2*CDCS + CS;

  // Reactions:
  r1:  => CS; ks1*(1 + UV*n3*(HY5 + FHY3)) - kdr1*(1 + n1*UV)*CS;
  r2:  => RUP; ks2*(1 + UV*UCS) - kdr2*RUP;
  r3: 2 UVR8M => UVR8D; k1*UVR8M^2;
  r4: 2 CS + 2 UVR8M -> UCS; ka1*CS^2*UVR8M^2 - kd1*UCS;
  r5: 2 CS + CD -> CDCS; ka2*CS^2*CD - kd2*CDCS;
  r6: UVR8M + RUP => UR; ka3*UVR8M*RUP;
  r7: 2 UR => UVR8D + 2 RUP; kd3*UR^2;
  r8: UVR8D => 2 UVR8M; k2*UVR8D;
  r9:  => HY5; ks3*(1 + n2*UV) - kdr3*(CDCS/(kdr3a + CDCS) + CDW/(kdr3b + CDW) - UCS/(ksr + UCS))*HY5;
  r10: CD + DWD -> CDW; ka4*CD*DWD - kd4*CDW;

  // Species initializations:
  CS = 0.2/Hypctol;
  CS has mole_per_volume;
  CD = 10/Hypctol;
  CD has mole_per_volume;
  CDCS = 2/Hypctol;
  CDCS has mole_per_volume;
  UVR8M = 0;
  UVR8M has mole_per_volume;
  UCS = 0;
  UCS has mole_per_volume;
  UVR8D = 20/Hypctol;
  UVR8D has mole_per_volume;
  RUP = 0;
  RUP has mole_per_volume;
  UR = 0;
  UR has mole_per_volume;
  UVR8_M = 0;
  UVR8_M has mole_per_volume;
  COP1 = 4.2/Hypctol;
  HY5 = 0.25/Hypctol;
  FHY3 = 5/Hypctol;
  DWD = 20/Hypctol;
  CDW = 0;

  // Compartment initializations:
  Hypctol = 1;

  // Variable initializations:
  ks1 = 0.23;
  ks2 = 4.0526;
  kdr1 = 0.1;
  kdr2 = 0.2118;
  k1 = 0.0043;
  k2 = 161.62;
  ka1 = 0.0372;
  ka2 = 0.0611;
  ka3 = 4.7207;
  kd1 = 94.3524;
  kd2 = 50.6973;
  kd3 = 0.5508;
  ks3 = 0.4397;
  kdr3 = 1.246;
  UV = 1;
  ka4 = 10.1285;
  kd4 = 1.1999;
  n1 = 3;
  n2 = 2;
  n3 = 3.5;
  kdr3a = 0.9735;
  kdr3b = 0.406;
  ksr = 0.7537;

  // Other declarations:
  var UM_Total, COP1_Total;
  const Hypctol, ks1, ks2, kdr1, kdr2, k1, k2, ka1, ka2, ka3, kd1, kd2, kd3;
  const ks3, kdr3, UV, ka4, kd4, n1, n2, n3, kdr3a, kdr3b, ksr;

  // Unit definitions:
  unit mole_per_volume = mole / litre;

  // CV terms:
  Hypctol hypernym "http://identifiers.org/bto/BTO:0000613"
  CS part "http://identifiers.org/uniprot/Q9SYX2",
          "http://identifiers.org/uniprot/P43254"
  CD part "http://identifiers.org/uniprot/Q8LGH4",
          "http://identifiers.org/uniprot/Q9M086"
  CDCS part "http://identifiers.org/uniprot/P43254",
            "http://identifiers.org/uniprot/Q9SYX2",
            "http://identifiers.org/uniprot/Q9M086",
            "http://identifiers.org/uniprot/Q8LGH4"
  UVR8M hypernym "http://identifiers.org/uniprot/Q9FN03"
  UCS part "http://identifiers.org/uniprot/Q9SYX2",
           "http://identifiers.org/uniprot/P43254",
           "http://identifiers.org/uniprot/Q9FN03"
  UVR8D hypernym "http://identifiers.org/uniprot/Q9FN03"
  RUP hypernym "http://identifiers.org/uniprot/Q9LTJ6"
  UR part "http://identifiers.org/uniprot/Q9LTJ6",
          "http://identifiers.org/uniprot/Q9FFA7"
  UVR8_M hypernym "http://identifiers.org/uniprot/Q9FN03"
  COP1 hypernym "http://identifiers.org/uniprot/P43254"
  HY5 hypernym "http://identifiers.org/uniprot/O24646"
  FHY3 hypernym "http://identifiers.org/uniprot/Q9LIE5"
  DWD hypernym "http://identifiers.org/interpro/IPR001680"
  CDW part "http://identifiers.org/uniprot/Q8LGH4",
           "http://identifiers.org/uniprot/Q9M086",
           "http://identifiers.org/interpro/IPR001680"
end

MODEL1407230000 is "Ouyang2014 - photomorphogenic UV-B signalling network"

MODEL1407230000 model_entity_is "http://identifiers.org/biomodels.db/MODEL1407230000"
MODEL1407230000 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000545"
MODEL1407230000 description "http://identifiers.org/pubmed/25049395"
MODEL1407230000 taxon "http://identifiers.org/taxonomy/3702"
MODEL1407230000 hypernym "http://identifiers.org/go/GO:0009640"
