// Created by libAntimony v2.13.0
model *MODEL1403310001()

  // Compartments and Species:
  compartment default, c2, compartment_;
  species $w in compartment_, IFNb_mRNA in compartment_, IFNb_env in c2, STATP2n in compartment_;
  species SOCS1m in compartment_, IRF7m in compartment_, IRF7Pn in compartment_;
  species IFNa_mRNA in compartment_, IFNa_env in c2, TNFam in compartment_;
  species TNFenv in c2, STATm in compartment_, STAT in compartment_;

  // Assignment Rules:
  NS := r5*time^n3/(bm^n3 + time^n3);
  IC1 := (1 + sp*(NS/delta1)^n1)/(1 + (NS/delta1)^n1);
  IC2 := (1 + sv*(NS/delta2)^n2)/(1 + (NS/delta2)^n2);
  IC2ifa := (1 + 3*sv*(NS/delta2)^n2)/(1 + (NS/delta2)^n2);
  TJ := (TJtot*(IFNb_env + IFNa_env)/(K3 + IFNb_env + IFNa_env))*1/(1 + K9*SOCS1m/delta);

  // Reactions:
  J1: $w => IFNb_mRNA; (r0*IC1 + k15*IRF7Pn)*IC2 - IFNb_mRNA*ln(2)/tao1;
  J2: $w => IFNb_env; (1000000000*C*vmax2/NA)*IFNb_mRNA/(K2 + IFNb_mRNA);
  J3: $w => STATP2n; K5*TJ*STAT/2/(K5 + STAT) - STATP2n*ln(2)/tao3;
  J4: $w => SOCS1m; (r3*IC1 + k8*STATP2n)*IC2 - SOCS1m*ln(2)/tao4;
  J5: $w => IRF7m; (k11*STATP2n + k14*IRF7Pn)*IC2 - IRF7m*ln(2)/tao6;
  J6: $w => IRF7Pn; k12*IC1*IRF7m;
  J7: $w => IFNa_mRNA; k16*IRF7Pn*IC2ifa - IFNa_mRNA*ln(2)/tao8;
  J8: $w => IFNa_env; (1000000000*C*vmax17/NA)*IFNa_mRNA/(K17 + IFNa_mRNA);
  J9: $w => TNFam; (r1*IC1 + rmax20*TNFenv/(K20 + TNFenv))*IC2 - TNFam*ln(2)/tao9;
  J10: $w => TNFenv; (1000000000*C*vmax19/NA)*TNFam/(K19 + TNFam);
  J11: $w => STATm; (r4*IC1 + k26*STATP2n)*IC2 - STATm*ln(2)/tao12;
  J12: $w => STAT; k28*STATm - STAT*ln(2)/tao13;

  // Species initializations:
  w = 0;
  IFNb_mRNA = 0;
  IFNb_env = 0;
  STATP2n = 0;
  SOCS1m = 0;
  IRF7m = 0;
  IRF7Pn = 0;
  IFNa_mRNA = 0;
  IFNa_env = 0;
  TNFam = 0;
  TNFenv = 0;
  STATm = 0;
  STAT = 0.1;

  // Compartment initializations:
  default = 1;
  default has volume;
  c2 = 1;
  c2 has volume;
  compartment_ = 1;
  compartment_ has volume;

  // Variable initializations:
  r5 = 1;
  r5 has dimensionless;
  n3 = 8;
  n3 has substance;
  bm = 4.5;
  bm has substance;
  sp = 0.1;
  sp has substance;
  delta1 = 0.1;
  delta1 has substance;
  n1 = 5;
  n1 has substance;
  sv = 0.1;
  sv has substance;
  delta2 = 0.4;
  delta2 has substance;
  n2 = 5;
  n2 has substance;
  TJtot = 0.0001;
  TJtot has substance;
  K3 = 0.0043;
  K3 has substance;
  K9 = 780;
  K9 has substance;
  delta = 0.0003;
  delta has substance;
  r0 = 0.003;
  r0 has substance;
  k15 = 3.6e-05;
  k15 has substance;
  tao1 = 2.5;
  tao1 has substance;
  C = 500000;
  C has substance;
  vmax2 = 72000;
  vmax2 has substance;
  NA = 6.023e+23;
  NA has substance;
  K2 = 72000;
  K2 has substance;
  K5 = 0.01;
  K5 has substance;
  tao3 = 0.56;
  tao3 has substance;
  r3 = 1e-07;
  r3 has substance;
  k8 = 0.0036;
  k8 has substance;
  tao4 = 0.46;
  tao4 has substance;
  k11 = 0.00036;
  k11 has substance;
  k14 = 3.204e-07;
  k14 has substance;
  tao6 = 1;
  k12 = 3600;
  k12 has substance;
  k16 = 3600;
  k16 has substance;
  tao8 = 2;
  tao8 has substance;
  vmax17 = 72000;
  vmax17 has substance;
  K17 = 0.002;
  K17 has substance;
  r1 = 0.00025;
  r1 has substance;
  rmax20 = 0.001;
  rmax20 has substance;
  K20 = 0.0006;
  K20 has substance;
  tao9 = 2;
  tao9 has substance;
  vmax19 = 154800;
  vmax19 has substance;
  K19 = 0.004;
  K19 has substance;
  r4 = 1e-06;
  r4 has substance;
  k26 = 0.360085;
  k26 has substance;
  tao12 = 1;
  tao12 has substance;
  k28 = 360;
  k28 has substance;
  tao13 = 15;
  tao13 has substance;

  // Other declarations:
  var NS, IC1, IC2, IC2ifa, TJ;
  const default, c2, compartment_, r5, n3, bm, sp, delta1, n1, sv, delta2;
  const n2, TJtot, K3, K9, delta, r0, k15, tao1, C, vmax2, NA, K2, K5, tao3;
  const r3, k8, tao4, k11, k14, tao6, k12, k16, tao8, vmax17, K17, r1, rmax20;
  const K20, tao9, vmax19, K19, r4, k26, tao12, k28, tao13;

  // Unit definitions:
  unit substance = 1e-06 mole;
  unit volume = litre;
  unit area = metre^2;
  unit length = metre;
  unit time_unit = 3600 second;

  // Display Names:
  time_unit is "time";
  c2 is "Environment";
  compartment_ is "Cell";

  // SBO terms:
  default.sboTerm = 290
  c2.sboTerm = 290
  compartment_.sboTerm = 290
  w.sboTerm = 291

  // CV terms:
  c2 hypernym "http://identifiers.org/bto/BTO:0000316"
  compartment_ hypernym "http://identifiers.org/bto/BTO:0002042"
  IFNb_mRNA encodement "http://identifiers.org/interpro/IPR015588"
  IFNb_env hypernym "http://identifiers.org/interpro/IPR015588"
  STATP2n hypernym "http://identifiers.org/interpro/IPR001217"
  SOCS1m encodement "http://identifiers.org/interpro/IPR028411"
  IRF7m encodement "http://identifiers.org/uniprot/Q92985"
  IRF7Pn hypernym "http://identifiers.org/uniprot/Q92985"
  IFNa_mRNA hypernym "http://identifiers.org/interpro/IPR015589"
  IFNa_env hypernym "http://identifiers.org/interpro/IPR015589"
  TNFam hypernym "http://identifiers.org/uniprot/P01375"
  TNFenv hypernym "http://identifiers.org/uniprot/P01375"
  STATm encodement "http://identifiers.org/interpro/IPR001217"
  STAT hypernym "http://identifiers.org/interpro/IPR001217"
end

MODEL1403310001 is "Fribourg2014 - Dynamics of viral antagonism and innate immune response (H1N1 influenza A virus - NC/99)"

MODEL1403310001 model_entity_is "http://identifiers.org/biomodels.db/MODEL1403310001"
MODEL1403310001 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000529"
MODEL1403310001 description "http://identifiers.org/pubmed/24594370"
MODEL1403310001 origin "http://identifiers.org/pubmed/20159146",
                       "http://identifiers.org/pubmed/20739535"
MODEL1403310001 hypernym "http://identifiers.org/go/GO:0009814"
MODEL1403310001 taxon "http://identifiers.org/taxonomy/9606",
                      "http://identifiers.org/taxonomy/381512"
MODEL1403310001 container "http://identifiers.org/cl/CL:0001056"
MODEL1403310001 property "http://identifiers.org/mamo/MAMO_0000046"
MODEL1403310001 version "http://identifiers.org/doid/DOID:8469"
