// Created by libAntimony v2.13.0
model *MODEL1306190001()

  // Compartments and Species:
  compartment compartment_;
  species N0 in compartment_, N1 in compartment_, N2 in compartment_;

  // Assignment Rules:
  T := N0 + N1 + N2;
  f0 := r0*N0*(1 - T/K);
  p00 := 1 - p01;
  f1 := r1*N1*(1 - T/K);
  p11 := 1 - p12;

  // Reactions:
  R0X: N0 => ; d0*N0;
  R01: N0 => N0 + N1; p01*f0;
  R00: N0 => 2 N0; p00*f0;
  R1X: N1 => ; d1*N1;
  R12: N1 => N1 + N2; p12*f1;
  R11: N1 => 2 N1; p11*f1;
  R2X: N2 => ; d2*N2;

  // Species initializations:
  N0 = 1.75444831412765/compartment_;
  N1 = 27.40585059/compartment_;
  N2 = 45.6191494109/compartment_;

  // Compartment initializations:
  compartment_ = 1;

  // Variable initializations:
  d0 = 0.1;
  d0 has per_day;
  d1 = 0.420467092599869;
  d1 has per_day;
  d2 = 1.10138534772246;
  d2 has per_day;
  T has cell;
  K = 120;
  K has cell;
  r0 = 1.83898685224665;
  r0 has per_day;
  f0 has cell_per_day;
  p00 has dimensionless;
  p01 = 0.855699855699856;
  p01 has dimensionless;
  r1 = 5.88010232010212;
  r1 has per_day;
  f1 has cell_per_day;
  p11 has dimensionless;
  p12 = 0.827377484810943;
  p12 has dimensionless;

  // Other declarations:
  var T, f0, p00, f1, p11;
  const compartment_, d0, d1, d2, K, r0, p01, r1, p12;

  // Unit definitions:
  unit substance = item;
  unit time_unit = 86400 second;
  unit volume = dimensionless;
  unit per_day = 1 / 86400 second;
  unit cell = item;
  unit cell_per_day = item / 86400 second;

  // Display Names:
  substance is "cell";
  time_unit is "day";
  per_day is "per day";
  cell_per_day is "cell per_day";
  compartment_ is "crypt";
  T is "cellularity";
  K is "capacity";
  f0 is "N0 division rate";
  f1 is "N1 division rate";
  R0X is "N0 death";
  R01 is "N0 differentiation";
  R00 is "N0 renewal";
  R1X is "N1 death";
  R12 is "N1 differentiation";
  R11 is "N1 renewal";
  R2X is "N2 death";

  // CV terms:
  compartment_ hypernym "http://identifiers.org/bto/BTO:0000305"
  N0 hypernym "http://identifiers.org/cl/CL:0000034"
  N1 hypernym "http://identifiers.org/cl/CL:0000034"
  N2 hypernym "http://identifiers.org/cl/CL:0000034"
end

MODEL1306190001 is "Smallbone2013 - Colon Crypt cycle - Version 1"

MODEL1306190001 model_entity_is "http://identifiers.org/biomodels.db/MODEL1306190001"
MODEL1306190001 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000519"
MODEL1306190001 description "http://identifiers.org/pubmed/24354351"
MODEL1306190001 model_entity_is "http://identifiers.org/biomodels.db/MODEL1306190001"
MODEL1306190001 origin "http://identifiers.org/biomodels.db/BIOMD0000000520"
MODEL1306190001 hypernym "http://identifiers.org/go/GO:0048863"
MODEL1306190001 container "http://identifiers.org/bto/BTO:0000305"
MODEL1306190001 taxon "http://identifiers.org/taxonomy/39107"
MODEL1306190001 property "http://identifiers.org/mamo/MAMO_0000046"
