// Created by libAntimony v2.13.0
model *Model_1()

  // Compartments and Species:
  compartment compartment_1;
  species $species_1 in compartment_1, $species_20 in compartment_1, $species_15 in compartment_1;
  species $species_13 in compartment_1, $species_11 in compartment_1, $species_2 in compartment_1;
  species $species_18 in compartment_1, $species_21 in compartment_1, $species_17 in compartment_1;
  species $species_16 in compartment_1, $species_3 in compartment_1, $species_26 in compartment_1;
  species species_22 in compartment_1, $species_6 in compartment_1, $species_4 in compartment_1;
  species $species_9 in compartment_1, $species_5 in compartment_1, $species_10 in compartment_1;
  species $species_7 in compartment_1, $species_25 in compartment_1, $species_8 in compartment_1;
  species $species_12 in compartment_1, $species_19 in compartment_1, $species_14 in compartment_1;
  species $species_23 in compartment_1, $species_24 in compartment_1;

  // Assignment Rules:
  parameter_9 := parameter_8/parameter_10;
  species_20 := species_8 - 2*species_13 - species_17;
  species_15 := species_14 - 2*species_11 - species_16;
  species_11 := (parameter_13 + 1)*species_1 - parameter_13*species_13;
  species_18 := species_19 - species_17;
  species_21 := species_12 - species_16;
  species_16 := (parameter_13 + 1)*species_2 - parameter_13*species_17;
  species_9 := species_7*(parameter_21/(1 + parameter_21));
  species_10 := (parameter_13 + 1)*(parameter_14 - species_3) - parameter_13*species_6;
  species_25 := species_7*(1/(1 + parameter_21));
  parameter_21 := (parameter_16/(1 - parameter_16))*((parameter_4 + 1)/parameter_4);
  species_12 := (parameter_13 + 1)*parameter_15 - parameter_13*species_19;
  species_14 := (parameter_13 + 1)*species_3 - parameter_13*species_8;
  parameter_19 := parameter_3;
  species_23 := species_5 + species_7 + species_24 + species_26;
  parameter_10 := 0.171;
  parameter_20 := (species_10 + species_14)/Metabolite_9;

  // Rate Rules:
  species_1' = (1/(1 + parameter_13))*(parameter_9*(parameter_13*species_20^2 + species_15^2) - parameter_8*(parameter_13*species_13 + species_11));
  species_13' = parameter_9*species_20^2 - (parameter_8 + parameter_3*parameter_11)*species_13;
  species_2' = (1/(parameter_13 + 1))*(parameter_9*(parameter_13*species_18*species_20 + species_15*species_21) - parameter_8*(parameter_13*species_17 + species_16));
  species_17' = parameter_9*species_18*species_20 - (parameter_8 + parameter_3*parameter_11)*species_17;
  species_3' = (1/(1 + parameter_13))*(parameter_13*parameter_6*species_26*(parameter_17/(parameter_17 + species_22))*species_6 - parameter_7*species_15);
  species_26' = parameter_1*(parameter_22*species_24 - parameter_12*(1 - parameter_28)*species_26);
  species_6' = parameter_2*species_10 - (parameter_3 + parameter_6*species_26*(parameter_17/(parameter_17 + species_22)))*species_6;
  species_4' = parameter_1*(parameter_27 + parameter_26*species_16 - (parameter_18*species_9 + parameter_25)*species_4);
  species_5' = parameter_1*((1 - parameter_5)*(1 - parameter_16) - (parameter_4 + (1 - parameter_28))*species_5);
  species_7' = parameter_1*(parameter_4*species_5 - (1 - parameter_28)*species_25 - parameter_18*species_4*species_9);
  species_8' = parameter_6*species_26*(parameter_17/(parameter_17 + species_22))*species_6 + parameter_2*species_15 - parameter_3*(species_20 + parameter_11*(species_17 + 2*species_13));
  species_19' = parameter_19*species_21 - parameter_3*(species_18 + parameter_11*species_17);
  species_24' = parameter_1*(parameter_18*species_4*species_9 - (parameter_22 + parameter_12*(1 - parameter_28))*species_24);

  // Species initializations:
  species_1 = 0;
  species_13 = 0;
  species_2 = 0;
  species_17 = 0;
  species_3 = 0;
  species_26 = 0;
  species_22 = 0;
  species_6 = parameter_14*parameter_2*(1 + parameter_13)/(parameter_3 + parameter_13*parameter_2);
  species_4 = parameter_23*parameter_24;
  species_5 = (1 - parameter_16)/(parameter_4 + 1);
  species_7 = (parameter_16 + parameter_4)/(1 + parameter_4);
  species_8 = 0;
  species_19 = parameter_15;
  species_24 = 0;

  // Compartment initializations:
  compartment_1 = 1;

  // Variable initializations:
  parameter_13 = 2.27;
  parameter_8 = 60;
  parameter_6 = 21.3715;
  parameter_17 = 0.196565;
  parameter_7 = 24;
  parameter_23 = 2;
  parameter_24 = 2;
  parameter_1 = 0.32;
  parameter_27 = 0;
  parameter_26 = 0;
  parameter_18 = 100;
  parameter_25 = 0.35;
  parameter_16 = 0.05;
  parameter_4 = 0.08;
  parameter_5 = 0;
  parameter_28 = 0;
  parameter_14 = 1;
  parameter_2 = 20;
  parameter_3 = 9.36;
  parameter_11 = 5.7;
  parameter_15 = 1;
  parameter_22 = 24.5383;
  parameter_12 = 4;
  Metabolite_9 = species_10;

  // Other declarations:
  var parameter_9, parameter_21, parameter_19, parameter_10, parameter_20;
  const compartment_1, parameter_13, parameter_8, parameter_6, parameter_17;
  const parameter_7, parameter_23, parameter_24, parameter_1, parameter_27;
  const parameter_26, parameter_18, parameter_25, parameter_16, parameter_4;
  const parameter_5, parameter_28, parameter_14, parameter_2, parameter_3;
  const parameter_11, parameter_15, parameter_22, parameter_12, Metabolite_9;

  // Unit definitions:
  unit volume = dimensionless;
  unit time_unit = 3600 second;
  unit substance = dimensionless;

  // Display Names:
  time_unit is "time";
  compartment_1 is "Cell";
  species_1 is "S22";
  parameter_13 is "a";
  parameter_9 is "kon";
  species_20 is "pS2fc";
  species_15 is "pS2fn";
  parameter_8 is "koff";
  species_13 is "S22c";
  species_11 is "S22n";
  species_2 is "S24";
  species_18 is "S4fc";
  species_21 is "S4fn";
  species_17 is "S24c";
  species_16 is "S24n";
  species_3 is "pS2tot";
  parameter_6 is "kp";
  species_26 is "Ract";
  parameter_17 is "KSBI";
  species_22 is "SBI";
  species_6 is "S2c";
  parameter_7 is "kdp";
  species_4 is "TGF";
  parameter_23 is "Tmax in ng/ml";
  parameter_24 is "TSca";
  parameter_1 is "kd";
  parameter_27 is "k'synTbas";
  parameter_26 is "k'synT";
  parameter_18 is "k'T";
  species_9 is "Rcom_S";
  parameter_25 is "k'cc";
  species_5 is "R";
  parameter_16 is "rc0";
  parameter_4 is "alpha";
  parameter_5 is "CHX";
  parameter_28 is "MG132";
  parameter_14 is "S2tot";
  parameter_2 is "kex";
  parameter_3 is "kin";
  species_10 is "S2n";
  species_7 is "Rcom";
  species_25 is "Rcom_I";
  species_8 is "pS2c";
  parameter_11 is "CIF";
  parameter_21 is "Ktr";
  species_12 is "S4n";
  parameter_15 is "S4tot";
  species_19 is "S4c";
  species_14 is "pS2n";
  parameter_19 is "kex4";
  species_23 is "Rtot";
  species_24 is "RT";
  parameter_22 is "k'act";
  parameter_12 is "D";
  parameter_10 is "KDiss";
  parameter_20 is "Total Nuc S2 for fit";
  Metabolite_9 is "Initial for S2n";

  // SBO terms:
  species_1.sboTerm = 297
  parameter_13.sboTerm = 360
  parameter_9.sboTerm = 337
  parameter_8.sboTerm = 282
  species_13.sboTerm = 297
  species_11.sboTerm = 297
  species_2.sboTerm = 297
  species_17.sboTerm = 297
  species_16.sboTerm = 297
  parameter_6.sboTerm = 9
  parameter_17.sboTerm = 282
  species_22.sboTerm = 390
  parameter_7.sboTerm = 9
  parameter_23.sboTerm = 470
  parameter_24.sboTerm = 470
  parameter_1.sboTerm = 9
  parameter_27.sboTerm = 9
  parameter_26.sboTerm = 9
  parameter_18.sboTerm = 9
  parameter_25.sboTerm = 9
  parameter_16.sboTerm = 540
  parameter_4.sboTerm = 9
  parameter_5.sboTerm = 390
  parameter_28.sboTerm = 9
  parameter_14.sboTerm = 361
  parameter_2.sboTerm = 9
  parameter_3.sboTerm = 9
  parameter_11.sboTerm = 380
  parameter_21.sboTerm = 281
  parameter_15.sboTerm = 361
  parameter_19.sboTerm = 9
  parameter_22.sboTerm = 9
  parameter_12.sboTerm = 360
  parameter_10.sboTerm = 282
  parameter_20.sboTerm = 360
  Metabolite_9.sboTerm = 360

  // CV terms:
  compartment_1 hypernym "http://identifiers.org/go/GO:0005623"
  species_1 part "http://identifiers.org/uniprot/Q15796"
  species_20 hypernym "http://identifiers.org/uniprot/Q15796"
  species_20 container "http://identifiers.org/go/GO:0005737"
  species_15 hypernym "http://identifiers.org/uniprot/Q15796"
  species_15 container "http://identifiers.org/go/GO:0005634"
  species_13 part "http://identifiers.org/uniprot/Q15796"
  species_13 container "http://identifiers.org/go/GO:0005737"
  species_11 part "http://identifiers.org/uniprot/Q15796"
  species_11 container "http://identifiers.org/go/GO:0005634"
  species_2 part "http://identifiers.org/uniprot/Q15796",
                 "http://identifiers.org/uniprot/Q13485"
  species_18 hypernym "http://identifiers.org/uniprot/Q13485"
  species_18 container "http://identifiers.org/go/GO:0005737"
  species_21 hypernym "http://identifiers.org/uniprot/Q13485"
  species_21 container "http://identifiers.org/go/GO:0005634"
  species_17 part "http://identifiers.org/uniprot/Q15796",
                  "http://identifiers.org/uniprot/Q13485"
  species_17 container "http://identifiers.org/go/GO:0005737"
  species_16 part "http://identifiers.org/uniprot/Q15796",
                  "http://identifiers.org/uniprot/Q13485"
  species_16 container "http://identifiers.org/go/GO:0005634"
  species_3 part "http://identifiers.org/uniprot/Q15796",
                 "http://identifiers.org/kegg.compound/C00562"
  species_26 hypernym "http://identifiers.org/uniprot/P36897"
  species_22 hypernym "http://identifiers.org/chebi/CHEBI:35222"
  species_6 hypernym "http://identifiers.org/uniprot/Q15796"
  species_6 container "http://identifiers.org/go/GO:0005737"
  species_4 hypernym "http://identifiers.org/uniprot/P01137"
  species_9 hypernym "http://identifiers.org/uniprot/P36897"
  species_9 container "http://identifiers.org/go/GO:0016020"
  species_5 hypernym "http://identifiers.org/uniprot/P36897"
  species_5 container "http://identifiers.org/go/GO:0005622"
  species_10 hypernym "http://identifiers.org/uniprot/Q15796"
  species_10 container "http://identifiers.org/go/GO:0005634"
  species_7 hypernym "http://identifiers.org/uniprot/P36897"
  species_7 container "http://identifiers.org/go/GO:0005622"
  species_25 hypernym "http://identifiers.org/uniprot/P36897"
  species_8 part "http://identifiers.org/uniprot/Q15796",
                 "http://identifiers.org/kegg.compound/C00562"
  species_8 container "http://identifiers.org/go/GO:0005737"
  species_12 hypernym "http://identifiers.org/uniprot/Q13485"
  species_12 container "http://identifiers.org/go/GO:0005634"
  species_19 part "http://identifiers.org/uniprot/Q13485"
  species_19 container "http://identifiers.org/go/GO:0005737"
  species_14 part "http://identifiers.org/uniprot/Q15796",
                  "http://identifiers.org/kegg.compound/C00562"
  species_14 container "http://identifiers.org/go/GO:0005634"
  species_23 hypernym "http://identifiers.org/uniprot/P36897"
  species_24 hypernym "http://identifiers.org/uniprot/P36897"
end

Model_1 is "Vizan2013 - TGF pathway long term signaling"

Model_1 model_entity_is "http://identifiers.org/biomodels.db/MODEL1203120000"
Model_1 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000499"
Model_1 description "http://identifiers.org/pubmed/24327760"
Model_1 model_entity_is "http://identifiers.org/biomodels.db/MODEL1203120000"
Model_1 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000499"
Model_1 origin "http://identifiers.org/biomodels.db/BIOMD0000000173"
Model_1 taxon "http://identifiers.org/taxonomy/9606"
Model_1 hypernym "http://identifiers.org/go/GO:0007179",
                 "http://identifiers.org/go/GO:0060395"
