// Created by libAntimony v2.13.0
model *MODEL1305280000()

  // Compartments and Species:
  compartment compartment_;
  species L in compartment_, R in compartment_, LR in compartment_, Gabg in compartment_;
  species RGabg in compartment_, LRGabg in compartment_, RRGSm in compartment_;
  species LRRGSm in compartment_, RRGSmGabg in compartment_, LRRGSmGabg in compartment_;
  species GaGTP in compartment_, Gbg in compartment_, Effector in compartment_;
  species GaGTPEffector in compartment_, RGSc in compartment_, RGSm in compartment_;
  species RGSmGaGTP in compartment_, GaGTPEffectorOFF in compartment_, RGSmGaGTPEffectorOFF in compartment_;
  species GaGDPP in compartment_, LRRGSmGaGTP in compartment_, RRGSmGaGTP in compartment_;
  species LRRGSmGaGTPEffectorOFF in compartment_, GaGDP in compartment_, P in compartment_;
  species z1 in compartment_, z2 in compartment_, z3 in compartment_;

  // Reactions:
  R1: L + R => LR; compartment_*L*R*R1_k1;
  R2: R + Gabg => RGabg; compartment_*R*Gabg*R2_k2;
  R3: LR + Gabg => LRGabg; compartment_*LR*Gabg*R3_k3;
  R4: L + RGabg => LRGabg; compartment_*L*RGabg*R4_k4;
  R5: L + RRGSm => LRRGSm; compartment_*L*RRGSm*R5_k5;
  R6: RRGSm + Gabg => RRGSmGabg; compartment_*RRGSm*Gabg*R6_k6;
  R7: LRRGSm + Gabg => LRRGSmGabg; compartment_*LRRGSm*Gabg*R7_k7;
  R8: L + RRGSmGabg => LRRGSmGabg; compartment_*L*RRGSmGabg*R8_k8;
  R9: LRGabg => LR + GaGTP + Gbg; compartment_*LRGabg*R9_k9;
  R10: Gabg => GaGTP + Gbg; compartment_*Gabg*R10_k10;
  R11: LRRGSmGabg => GaGTP + Gbg + LRRGSm; compartment_*LRRGSmGabg*R11_k11;
  R12: Effector + GaGTP => GaGTPEffector; compartment_*Effector*GaGTP*R12_k12;
  R13: RGSc => RGSm; compartment_*RGSc*R13_k13;
  R14: RGSm => RGSc; compartment_*RGSm*R14_k14;
  R15: R + RGSc => RRGSm; compartment_*R*RGSc*R15_k15;
  R16: RRGSm => R + RGSm; compartment_*RRGSm*R16_k16;
  R17: LR + RGSc => LRRGSm; compartment_*LR*RGSc*R17_k17;
  R18: LRRGSm => LR + RGSm; compartment_*LRRGSm*R18_k18;
  R19: RGabg + RGSc => RRGSmGabg; compartment_*RGabg*RGSc*R19_k19;
  R20: RRGSmGabg => RGabg + RGSm; compartment_*RRGSmGabg*R20_k20;
  R21: LRGabg + RGSc => LRRGSmGabg; compartment_*LRGabg*RGSc*R21_k21;
  R22: GaGTP + RGSc => RGSmGaGTP; compartment_*GaGTP*RGSc*R22_k22;
  R23: RGSmGaGTP => GaGTP + RGSc; compartment_*RGSmGaGTP*R23_k23;
  R24: GaGTPEffectorOFF + RGSc => RGSmGaGTPEffectorOFF; compartment_*GaGTPEffectorOFF*RGSc*R24_k24;
  R25: GaGTPEffector => GaGTPEffectorOFF; compartment_*GaGTPEffector*R25_k25;
  R26: GaGTP => GaGDPP; compartment_*GaGTP*R26_k26;
  R27: GaGTP + RGSm => RGSmGaGTP; compartment_*GaGTP*RGSm*R27_k27;
  R28: RGSmGaGTP => GaGDPP + RGSc; compartment_*RGSmGaGTP*R28_k28;
  R29: GaGTP + LRRGSm => LRRGSmGaGTP; compartment_*GaGTP*LRRGSm*R29_k29;
  R30: LRRGSmGaGTP => GaGDPP + LRRGSm; compartment_*LRRGSmGaGTP*R30_k30;
  R31: GaGTP + RRGSm => RRGSmGaGTP; compartment_*GaGTP*RRGSm*R31_k31;
  R32: RRGSmGaGTP => GaGDPP + RRGSm; compartment_*RRGSmGaGTP*R32_k32;
  R33: GaGTPEffectorOFF => GaGDPP + Effector; compartment_*GaGTPEffectorOFF*R33_k33;
  R34: GaGTPEffectorOFF + RGSm => RGSmGaGTPEffectorOFF; compartment_*GaGTPEffectorOFF*RGSm*R34_k34;
  R35: RGSmGaGTPEffectorOFF => GaGDPP + RGSc + Effector; compartment_*RGSmGaGTPEffectorOFF*R35_k35;
  R36: GaGTPEffectorOFF + LRRGSm => LRRGSmGaGTPEffectorOFF; compartment_*GaGTPEffectorOFF*LRRGSm*R36_k36;
  R37: LRRGSmGaGTPEffectorOFF => GaGDPP + LRRGSm + Effector; compartment_*LRRGSmGaGTPEffectorOFF*R37_k37;
  R38: GaGDPP => GaGDP + P; compartment_*GaGDPP*R38_k38;
  R39: GaGDP + Gbg => Gabg; compartment_*GaGDP*Gbg*R39_k39;
  R40: P => ; compartment_*P*R40_k40;
  R41:  => z1; compartment_*GaGTPEffector*ka;
  R42: z1 => z2; compartment_*z1*ka;
  R43: z2 => z3; compartment_*z2*ka;
  R44: z3 => ; compartment_*z3*ka;

  // Events:
  Ligand_addition: at time >= 14: L = L + Ligand_conc;

  // Species initializations:
  L = 0;
  L has nanoMolar;
  R = 205;
  R has nanoMolar;
  LR = 0;
  LR has nanoMolar;
  Gabg = 0;
  Gabg has nanoMolar;
  RGabg = 0;
  RGabg has nanoMolar;
  LRGabg = 0;
  LRGabg has nanoMolar;
  RRGSm = 0;
  RRGSm has nanoMolar;
  LRRGSm = 0;
  LRRGSm has nanoMolar;
  RRGSmGabg = 0;
  RRGSmGabg has nanoMolar;
  LRRGSmGabg = 0;
  LRRGSmGabg has nanoMolar;
  GaGTP = 0;
  GaGTP has nanoMolar;
  Gbg = 205;
  Gbg has nanoMolar;
  Effector = 305;
  Effector has nanoMolar;
  GaGTPEffector = 0;
  GaGTPEffector has nanoMolar;
  RGSc = 60;
  RGSc has nanoMolar;
  RGSm = 0;
  RGSm has nanoMolar;
  RGSmGaGTP = 0;
  RGSmGaGTP has nanoMolar;
  GaGTPEffectorOFF = 0;
  GaGTPEffectorOFF has nanoMolar;
  RGSmGaGTPEffectorOFF = 0;
  RGSmGaGTPEffectorOFF has nanoMolar;
  GaGDPP = 0;
  GaGDPP has nanoMolar;
  LRRGSmGaGTP = 0;
  LRRGSmGaGTP has nanoMolar;
  RRGSmGaGTP = 0;
  RRGSmGaGTP has nanoMolar;
  LRRGSmGaGTPEffectorOFF = 0;
  LRRGSmGaGTPEffectorOFF has nanoMolar;
  GaGDP = 205;
  GaGDP has nanoMolar;
  P = 0;
  P has nanoMolar;
  z1 = 0;
  z1 has nanoMolar;
  z2 = 0;
  z2 has nanoMolar;
  z3 = 0;
  z3 has nanoMolar;

  // Compartment initializations:
  compartment_ = 1;

  // Variable initializations:
  Ligand_conc = 0.1;
  Ligand_conc has nanoMolar;
  ka = 1.5;
  ka has FirstOrder;
  R1_k1 = 0.0025;
  R1_k1 has SecondOrder;
  R2_k2 = 0.005;
  R2_k2 has SecondOrder;
  R3_k3 = 0.02;
  R3_k3 has SecondOrder;
  R4_k4 = 0.005;
  R4_k4 has SecondOrder;
  R5_k5 = 0.005;
  R5_k5 has SecondOrder;
  R6_k6 = 0.005;
  R6_k6 has SecondOrder;
  R7_k7 = 0.02;
  R7_k7 has SecondOrder;
  R8_k8 = 0.005;
  R8_k8 has SecondOrder;
  R9_k9 = 50;
  R9_k9 has FirstOrder;
  R10_k10 = 0.2;
  R10_k10 has FirstOrder;
  R11_k11 = 40;
  R11_k11 has FirstOrder;
  R12_k12 = 10;
  R12_k12 has SecondOrder;
  R13_k13 = 0.0005;
  R13_k13 has FirstOrder;
  R14_k14 = 0.005;
  R14_k14 has FirstOrder;
  R15_k15 = 0.1;
  R15_k15 has SecondOrder;
  R16_k16 = 100;
  R16_k16 has FirstOrder;
  R17_k17 = 0.1;
  R17_k17 has SecondOrder;
  R18_k18 = 100;
  R18_k18 has FirstOrder;
  R19_k19 = 0.1;
  R19_k19 has SecondOrder;
  R20_k20 = 0.1;
  R20_k20 has FirstOrder;
  R21_k21 = 0.1;
  R21_k21 has SecondOrder;
  R22_k22 = 60;
  R22_k22 has SecondOrder;
  R23_k23 = 0.05;
  R23_k23 has FirstOrder;
  R24_k24 = 0.0001;
  R24_k24 has SecondOrder;
  R25_k25 = 1;
  R25_k25 has FirstOrder;
  R26_k26 = 0.005;
  R26_k26 has FirstOrder;
  R27_k27 = 500;
  R27_k27 has SecondOrder;
  R28_k28 = 2.5;
  R28_k28 has FirstOrder;
  R29_k29 = 100;
  R29_k29 has SecondOrder;
  R30_k30 = 2.5;
  R30_k30 has FirstOrder;
  R31_k31 = 0.5;
  R31_k31 has SecondOrder;
  R32_k32 = 0.5;
  R32_k32 has FirstOrder;
  R33_k33 = 0.005;
  R33_k33 has FirstOrder;
  R34_k34 = 50;
  R34_k34 has SecondOrder;
  R35_k35 = 0.3;
  R35_k35 has FirstOrder;
  R36_k36 = 50;
  R36_k36 has SecondOrder;
  R37_k37 = 0.3;
  R37_k37 has FirstOrder;
  R38_k38 = 1000;
  R38_k38 has FirstOrder;
  R39_k39 = 1000;
  R39_k39 has SecondOrder;
  R40_k40 = 10;
  R40_k40 has FirstOrder;

  // Other declarations:
  const compartment_, Ligand_conc, ka;

  // Unit definitions:
  unit nanoMolar = 1e-9 mole / litre;
  unit hour = 3600 second;
  unit FirstOrder = 1 / 3600 second;
  unit SecondOrder = litre / (1e-9 mole * 3600 second);
  unit nanoMolar_volume = 1e-9 mole;

  // Display Names:
  nanoMolar is "nM";
  hour is "hr";
  FirstOrder is "1/hr";
  SecondOrder is "1/(nM*hr)";
  compartment_ is "cell";
  R1 is "Receptor-Ligand association";
  R2 is "Receptor-Gprotein association";
  R3 is "LR-Gprotein association";
  R4 is "Ligand-RGabg association";
  R5 is "Ligand-RRGSm association";
  R6 is "RRGSm-Gprotein association";
  R7 is "LRRGSm-Gprotein association";
  R8 is "Ligand-RRGSmGabg association";
  R9 is "Gprotein activation by LR";
  R10 is "Gprotein spontaneous activation";
  R11 is "Gprotein activation by LRRGSm";
  R12 is "Effector-GaGTP association";
  R13 is "RGS in cytosol moves to membrane";
  R14 is "RGS in membrane moves to cytosol";
  R15 is "Receptor recruits RGSc to membrane";
  R16 is "R-RGSm dissociation";
  R17 is "LR recruits RGSc to membrane";
  R18 is "LR-RGSm dissociation";
  R19 is "RGabg recruits RGSc to membrane";
  R20 is "RRGSmGabg dissociation";
  R21 is "LRGabg recruits RGSc to membrane";
  R22 is "GaGTP recruits RGSc to membrane";
  R23 is "RGSmGaGTP dissociation";
  R24 is "GaGTPEffectorOFF recruits RGS from cytosol";
  R25 is "Effector turns off";
  R26 is "GaGTP hydrolyzes GTP";
  R27 is "GaGTP-RGSm association";
  R28 is "RGSmGaGTP hydrolyzes GTP";
  R29 is "GaGTP-LRRGSm association";
  R30 is "LRRGSmGaGTP hydrolyzes GTP";
  R31 is "GaGTP-RRGSm association";
  R32 is "RRGSmGaGTP hydrolyzes GTP";
  R33 is "GaGTPEffectorOFF hydrolyzes GTP";
  R34 is "GaGTPEffectorOFF-RGSm association";
  R35 is "RGSmGaGTPEffectorOFF hydrolyzes GTP";
  R36 is "GaGTPEffectorOFF-LRRGSm association";
  R37 is "LRRGSmGaGTPEffectorOFF hydrolyzes GTP";
  R38 is "Phosphate release";
  R39 is "Gprotein subunits association";
  R40 is "Phosphate degradation";
  R41 is "Delay 1";
  R42 is "Delay 2";
  R43 is "Delay 3";
  R44 is "Final output";

  // SBO terms:
  compartment_.sboTerm = 290
  L.sboTerm = 280
  R.sboTerm = 244
  LR.sboTerm = 296
  Gabg.sboTerm = 297
  RGabg.sboTerm = 297
  LRGabg.sboTerm = 296
  RRGSm.sboTerm = 297
  LRRGSm.sboTerm = 296
  RRGSmGabg.sboTerm = 297
  LRRGSmGabg.sboTerm = 296
  GaGTP.sboTerm = 296
  Gbg.sboTerm = 297
  RGSc.sboTerm = 252
  RGSm.sboTerm = 252
  RGSmGaGTP.sboTerm = 296
  GaGDPP.sboTerm = 296
  LRRGSmGaGTP.sboTerm = 296
  RRGSmGaGTP.sboTerm = 296
  GaGDP.sboTerm = 296
  P.sboTerm = 247

  // CV terms:
  compartment_ hypernym "http://identifiers.org/go/GO:0005623"
  L hypernym "http://identifiers.org/biomodels.sbo/SBO:0000280"
  R hypernym "http://identifiers.org/interpro/IPR000239"
  LR part "http://identifiers.org/interpro/IPR000239",
          "http://identifiers.org/biomodels.sbo/SBO:0000280"
  Gabg part "http://identifiers.org/interpro/IPR001019",
            "http://identifiers.org/interpro/IPR001632",
            "http://identifiers.org/interpro/IPR001770"
  RGabg part "http://identifiers.org/interpro/IPR000239",
             "http://identifiers.org/interpro/IPR001019",
             "http://identifiers.org/interpro/IPR001632",
             "http://identifiers.org/interpro/IPR001770"
  LRGabg part "http://identifiers.org/interpro/IPR000239",
              "http://identifiers.org/interpro/IPR001019",
              "http://identifiers.org/interpro/IPR001632",
              "http://identifiers.org/interpro/IPR001770",
              "http://identifiers.org/biomodels.sbo/SBO:0000280"
  RRGSm part "http://identifiers.org/interpro/IPR000239",
             "http://identifiers.org/interpro/IPR000342"
  RRGSm container "http://identifiers.org/fma/FMA:63841"
  LRRGSm container "http://identifiers.org/fma/FMA:63841"
  LRRGSm part "http://identifiers.org/interpro/IPR000239",
              "http://identifiers.org/interpro/IPR000342",
              "http://identifiers.org/biomodels.sbo/SBO:0000280"
  RRGSmGabg part "http://identifiers.org/interpro/IPR000239",
                 "http://identifiers.org/interpro/IPR000342",
                 "http://identifiers.org/interpro/IPR001019",
                 "http://identifiers.org/interpro/IPR001632",
                 "http://identifiers.org/interpro/IPR001770"
  RRGSmGabg container "http://identifiers.org/fma/FMA:63841"
  LRRGSmGabg container "http://identifiers.org/fma/FMA:63841"
  LRRGSmGabg part "http://identifiers.org/interpro/IPR000239",
                  "http://identifiers.org/interpro/IPR001019",
                  "http://identifiers.org/interpro/IPR000342",
                  "http://identifiers.org/interpro/IPR001632",
                  "http://identifiers.org/interpro/IPR001770",
                  "http://identifiers.org/biomodels.sbo/SBO:0000280"
  GaGTP part "http://identifiers.org/chebi/CHEBI:15996",
             "http://identifiers.org/interpro/IPR001019"
  Gbg part "http://identifiers.org/interpro/IPR001632",
           "http://identifiers.org/interpro/IPR001770"
  Effector hypernym "http://identifiers.org/chebi/CHEBI:35224"
  GaGTPEffector part "http://identifiers.org/chebi/CHEBI:15996",
                     "http://identifiers.org/interpro/IPR001019"
  GaGTPEffector hypernym "http://identifiers.org/chebi/CHEBI:35224"
  RGSc container "http://identifiers.org/fma/FMA:66835"
  RGSc hypernym "http://identifiers.org/interpro/IPR000342"
  RGSm container "http://identifiers.org/fma/FMA:63841"
  RGSm hypernym "http://identifiers.org/interpro/IPR000342"
  RGSmGaGTP container "http://identifiers.org/fma/FMA:63841"
  RGSmGaGTP part "http://identifiers.org/chebi/CHEBI:15996",
                 "http://identifiers.org/interpro/IPR000342",
                 "http://identifiers.org/interpro/IPR001019"
  GaGTPEffectorOFF part "http://identifiers.org/chebi/CHEBI:15996",
                        "http://identifiers.org/interpro/IPR001019"
  GaGTPEffectorOFF property "http://identifiers.org/pato/PATO:0002355"
  GaGTPEffectorOFF hypernym "http://identifiers.org/chebi/CHEBI:35224"
  RGSmGaGTPEffectorOFF hypernym "http://identifiers.org/chebi/CHEBI:35224"
  RGSmGaGTPEffectorOFF part "http://identifiers.org/chebi/CHEBI:15996",
                            "http://identifiers.org/interpro/IPR000342",
                            "http://identifiers.org/interpro/IPR001019"
  RGSmGaGTPEffectorOFF property "http://identifiers.org/pato/PATO:0002355"
  GaGDPP part "http://identifiers.org/chebi/CHEBI:17552",
              "http://identifiers.org/interpro/IPR001019"
  GaGDPP property "http://identifiers.org/pato/PATO:0002220"
  LRRGSmGaGTP part "http://identifiers.org/chebi/CHEBI:15996",
                   "http://identifiers.org/interpro/IPR000342",
                   "http://identifiers.org/interpro/IPR000239",
                   "http://identifiers.org/interpro/IPR001019",
                   "http://identifiers.org/biomodels.sbo/SBO:0000280"
  RRGSmGaGTP part "http://identifiers.org/chebi/CHEBI:15996",
                  "http://identifiers.org/interpro/IPR000239",
                  "http://identifiers.org/interpro/IPR000342",
                  "http://identifiers.org/interpro/IPR001019"
  LRRGSmGaGTPEffectorOFF part "http://identifiers.org/chebi/CHEBI:15996",
                              "http://identifiers.org/interpro/IPR000239",
                              "http://identifiers.org/interpro/IPR001019",
                              "http://identifiers.org/interpro/IPR000342",
                              "http://identifiers.org/biomodels.sbo/SBO:0000280"
  LRRGSmGaGTPEffectorOFF hypernym "http://identifiers.org/chebi/CHEBI:35224"
  LRRGSmGaGTPEffectorOFF property "http://identifiers.org/pato/PATO:0002355"
  GaGDP part "http://identifiers.org/chebi/CHEBI:17552",
             "http://identifiers.org/interpro/IPR001019"
  P hypernym "http://identifiers.org/chebi/CHEBI:18367"
  z1 property "http://identifiers.org/biomodels.sbo/SBO:0000225"
  z2 property "http://identifiers.org/biomodels.sbo/SBO:0000225"
  z3 property "http://identifiers.org/biomodels.sbo/SBO:0000225"
end

MODEL1305280000 is "Croft2013 - GPCR-RGS interaction that compartmentalizes RGS activity"

MODEL1305280000 model_entity_is "http://identifiers.org/biomodels.db/MODEL1305280000"
MODEL1305280000 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000479"
MODEL1305280000 description "http://identifiers.org/pubmed/23900842"
MODEL1305280000 origin "http://identifiers.org/biomodels.db/BIOMD0000000439",
                       "http://identifiers.org/pubmed/15313578"
MODEL1305280000 taxon "http://identifiers.org/taxonomy/4932"
MODEL1305280000 hypernym "http://identifiers.org/go/GO:0043087"
MODEL1305280000 property "http://identifiers.org/mamo/MAMO_0000046"
