// Created by libAntimony v2.13.0
model *MODEL1302180006()

  // Compartments and Species:
  compartment default, c1;
  substanceOnly species $s3 in c1, s27 in c1, s45 in c1, s47 in c1, s48 in c1;
  substanceOnly species s50 in c1, s51 in c1, s52 in c1, s57 in c1, s58 in c1;
  substanceOnly species s60 in c1, s61 in c1, s62 in c1, s63 in c1, s64 in c1;
  substanceOnly species s65 in c1, s66 in c1, s116 in c1, s117 in c1, s118 in c1;

  // Reactions:
  re37: s51 + s47 => s45; k4*s47*s51;
  re38: s48 + s51 -> s50; k3*s51*s48 - k3r*s50;
  re41: s52 -> s48; k1*s3*s52 - k1r*s48;
  re42: s48 => s47; k2*s3*s48 - k2r*s47;
  re50: s45 -> s50; k5*s45 - k2*s3*s50;
  re51: s45 + s57 => s58; k6*s45*s57;
  re52: s58 -> s61; k5*s58 - k2*s3*s61;
  re53: s61 => s50 + s57; k7*s61;
  re54: s60 -> s62; k5*s60 - k2*s3*s62;
  re55: s58 -> s60; k10*s58*s27/(s58 + Km10) - V10r*s60/(s60 + Km10r);
  re56: s61 -> s62; k10*s61*s27/(s61 + Km10) - V10r*s62/(s62 + Km10r);
  re69: s63 => s64; re69_kCaM*(s45 + s58) + re69_kp*(s62 + s65) + re69_kpCaM*s60;
  re70: s65 => s66; V10r*s65/(s65 + Km10r);
  re71: s66 => s51 + s57; k7*s66;
  re72: s62 -> s65 + s48; k3r*s62 - k3*s65*s48;
  re131: s51 => s116; kD*s51;
  re132: s45 => s117 + s47; kD*s45;
  re133: s50 => s117 + s48; kD*s50;
  re134: s66 => s57 + s118; kD*s66;
  re135: s65 => s118 + s57; kD*s65;
  re136: s61 => s57 + s48; kD*s61;
  re137: s62 => s57 + s48; kD*s62;
  re138: s58 => s57 + s47; kD*s58;
  re139: s60 => s57 + s47; kD*s60;

  // Species initializations:
  s3 = 117.2/c1;
  s3 has substance_per_volume;
  s27 = 1.723/c1;
  s27 has substance_per_volume;
  s45 = 0.0415/c1;
  s45 has substance_per_volume;
  s47 = 2.827/c1;
  s47 has substance_per_volume;
  s48 = 347.52/c1;
  s48 has substance_per_volume;
  s50 = 2.12/c1;
  s50 has substance_per_volume;
  s51 = 34.98/c1;
  s51 has substance_per_volume;
  s52 = 7635.36/c1;
  s52 has substance_per_volume;
  s57 = 199987/c1;
  s57 has substance_per_volume;
  s58 = 1.037/c1;
  s58 has substance_per_volume;
  s60 = 0.0089/c1;
  s60 has substance_per_volume;
  s61 = 10.98/c1;
  s61 has substance_per_volume;
  s62 = 0.106/c1;
  s62 has substance_per_volume;
  s63 = 500000/c1;
  s63 has substance_per_volume;
  s64 = 0;
  s64 has substance_per_volume;
  s65 = 0.643/c1;
  s65 has substance_per_volume;
  s66 = 0.083/c1;
  s66 has substance_per_volume;
  s116 = 0;
  s116 has substance_per_volume;
  s117 = 0;
  s117 has substance_per_volume;
  s118 = 0;
  s118 has substance_per_volume;

  // Compartment initializations:
  default = 1;
  default has volume;
  c1 = 1;
  c1 has volume;

  // Variable initializations:
  k1 = 0.004;
  k1 has inv_sec_sub;
  k1r = 10.3;
  k1r has inv_sec;
  k2 = 0.08;
  k2 has inv_sec_sub;
  k2r = 1152;
  k2r has inv_sec;
  k4 = 0.015;
  k4 has inv_sec_sub;
  k3 = 0.00015;
  k3 has inv_sec_sub;
  k3r = 1.5;
  k3r has inv_sec;
  k10 = 0.1;
  k10 has inv_sec;
  Km10 = 5;
  Km10 has substance;
  Km10r = 20;
  Km10r has substance;
  V10r = 4;
  V10r has sub_sec;
  k6 = 0.002;
  k6 has inv_sec_sub;
  k7 = 1.5;
  k7 has inv_sec;
  kD = 9.45e-05;
  kD has inv_sec;
  k5 = 115.2;
  k5 has inv_sec;
  re69_kCaM = 17;
  re69_kCaM has inv_sec;
  re69_kp = 5;
  re69_kp has inv_sec;
  re69_kpCaM = 17;
  re69_kpCaM has inv_sec;

  // Other declarations:
  const default, c1, k1, k1r, k2, k2r, k4, k3, k3r, k10, Km10, Km10r, V10r;
  const k6, k7, kD, k5;

  // Unit definitions:
  unit time_unit = second;
  unit substance = 1e-09 mole;
  unit area = metre^2;
  unit length = metre;
  unit volume = litre;
  unit sub_sec = 1e-09 mole / second;
  unit inv_sec = 1 / second;
  unit inv_sec_sub = 1 / (1e-09 mole * second);
  unit nM_inv_s = 1e-9 mole / second;
  unit inv_nM_s = 1 / (1e-9 mole * second);
  unit substance_per_volume = 1e-09 mole / litre;

  // Display Names:
  time_unit is "time";
  c1 is "Cell";
  s3 is "Ca_c";
  s27 is "pp-AKT:PI3P";
  s45 is "eNOS-CaM-Ca4";
  s47 is "CaM-Ca4";
  s48 is "CaM-Ca2";
  s50 is "eNOS-CaM-Ca2";
  s51 is "eNOS-Cav-1";
  s52 is "Calmodulin";
  s57 is "Hsp90";
  s58 is "Hsp90-eNOS-CaM-Ca4";
  s60 is "Hsp90-p-eNOS-CaM-Ca4";
  s61 is "Hsp90-eNOS-CaM-Ca2";
  s62 is "Hsp90-p-eNOS-CaM-Ca2";
  s63 is "L-Arg";
  s64 is "NO";
  s65 is "Hsp90-p-eNOS";
  s66 is "Hsp90-eNOS";
  s116 is "sa49_degraded";

  // SBO terms:
  s45.sboTerm = 297
  s47.sboTerm = 297
  s48.sboTerm = 297
  s50.sboTerm = 297
  s51.sboTerm = 297
  s58.sboTerm = 297
  s60.sboTerm = 297
  s61.sboTerm = 297
  s62.sboTerm = 297
  s63.sboTerm = 291
  s65.sboTerm = 297
  s66.sboTerm = 297
  s116.sboTerm = 291
  s117.sboTerm = 291
  s118.sboTerm = 291

  // CV terms:
  c1 identity "http://identifiers.org/go/GO:0005623"
  s3 identity "http://identifiers.org/chebi/CHEBI:29108"
  s3 container "http://identifiers.org/go/GO:0005623"
  s27 part "http://identifiers.org/uniprot/P31749",
           "http://identifiers.org/pubchem.compound/53480352"
  s27 property "http://identifiers.org/psimod/MOD:00696"
  s45 part "http://identifiers.org/chebi/CHEBI:29108",
           "http://identifiers.org/uniprot/P62158"
  s47 part "http://identifiers.org/chebi/CHEBI:29108",
           "http://identifiers.org/uniprot/P62158"
  s48 part "http://identifiers.org/chebi/CHEBI:29108",
           "http://identifiers.org/uniprot/P62158"
  s50 part "http://identifiers.org/chebi/CHEBI:29108",
           "http://identifiers.org/uniprot/P62158"
  s51 part "http://identifiers.org/uniprot/Q03135"
  s51 hypernym "http://identifiers.org/go/GO:0051001"
  s52 hypernym "http://identifiers.org/uniprot/P62158"
  s57 hypernym "http://identifiers.org/uniprot/P08238"
  s58 part "http://identifiers.org/chebi/CHEBI:29108",
           "http://identifiers.org/uniprot/P08238",
           "http://identifiers.org/uniprot/P62158"
  s60 property "http://identifiers.org/chebi/CHEBI:29108",
               "http://identifiers.org/uniprot/P08238",
               "http://identifiers.org/uniprot/P62158"
  s60 property "http://identifiers.org/psimod/MOD:00696"
  s61 part "http://identifiers.org/chebi/CHEBI:29108",
           "http://identifiers.org/uniprot/P08238",
           "http://identifiers.org/uniprot/P62158"
  s62 property "http://identifiers.org/psimod/MOD:00696"
  s62 part "http://identifiers.org/chebi/CHEBI:29108",
           "http://identifiers.org/uniprot/P08238",
           "http://identifiers.org/uniprot/P62158"
  s63 hypernym "http://identifiers.org/chebi/CHEBI:16467"
  s64 hypernym "http://identifiers.org/chebi/CHEBI:16480"
  s65 part "http://identifiers.org/uniprot/P08238"
  s65 property "http://identifiers.org/psimod/MOD:00696"
  s66 part "http://identifiers.org/uniprot/P08238"
end

MODEL1302180006 is "Koo2013 - Shear stress induced NO production - Model 4"

MODEL1302180006 model_entity_is "http://identifiers.org/biomodels.db/MODEL1302180006"
MODEL1302180006 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000467"
MODEL1302180006 description "http://identifiers.org/pubmed/23708369"
MODEL1302180006 taxon "http://identifiers.org/taxonomy/9606"
MODEL1302180006 hypernym "http://identifiers.org/reactome/REACT_12443.3"
MODEL1302180006 hypernym "http://identifiers.org/go/GO:0006809",
                         "http://identifiers.org/go/GO:0002537"
