// Created by libAntimony v2.13.0
model *MODEL1302180004()

  // Compartments and Species:
  compartment default, c1;
  substanceOnly species s14 in c1, s15 in c1, s16 in c1, s17 in c1, s18 in c1;
  substanceOnly species s19 in c1, s20 in c1, s21 in c1, s22 in c1, s23 in c1;
  substanceOnly species s24 in c1, s25 in c1, s26 in c1, s27 in c1, s28 in c1;
  substanceOnly species s119 in default;

  // Reactions:
  re57: s22 -> s20; exp(re57_unity - (s23/re57_tf)^1.8)*re57_normal*(s23/re57_unimol)^0.8*(re57_unity - (s23/re57_tf)^1.8);
  re58: s19 => s17; re58_k2*s19*s20/(re58_Km2 + s19);
  re59: s17 => s19; re59_k3*s17*s18/(re59_Km3 + s17);
  re60: s17 + s16 -> s28; re60_k4*s17*s16 - re60_kr4*s28;
  re61: s28 => s26; re61_k8*s28*s14/(re61_Km8 + s28);
  re62: s26 => s27; re62_k10*s26*s24/(re62_Km10 + s26);
  re63: s26 => s28; re63_k7*s26*s15/(re63_Km7 + s26);
  re64: s27 => s26; re64_k9*s27*s15/(re64_Km9 + s27);
  re65: s27 => s17 + s16; re65_k11*s27*s15/(re65_Km11 + s27);
  re66: s25 => s14; re66_k5*s17*s25;
  re67: s14 => s25; re67_k6*s14;
  re68: s21 => s23; re68_unitime;

  // Species initializations:
  s14 = 0.246/c1;
  s14 has substance_per_volume;
  s15 = 150/c1;
  s15 has substance_per_volume;
  s16 = 167.616/c1;
  s16 has substance_per_volume;
  s17 = 0.345/c1;
  s17 has substance_per_volume;
  s18 = 0.1/c1;
  s18 has substance_per_volume;
  s19 = 6967.271/c1;
  s19 has substance_per_volume;
  s20 = 0.03/c1;
  s20 has substance_per_volume;
  s21 = 0;
  s21 has substance_per_volume;
  s22 = 99.97/c1;
  s22 has substance_per_volume;
  s23 = 0;
  s23 has substance_per_volume;
  s24 = 3/c1;
  s24 has substance_per_volume;
  s25 = 999.754/c1;
  s25 has substance_per_volume;
  s26 = 1.457/c1;
  s26 has substance_per_volume;
  s27 = 1.723/c1;
  s27 has substance_per_volume;
  s28 = 29.203/c1;
  s28 has substance_per_volume;
  s119 = 0;
  s119 has substance_per_volume;

  // Compartment initializations:
  default = 1;
  default has volume;
  c1 = 1;
  c1 has volume;

  // Variable initializations:
  re57_normal = 0.907;
  re57_normal has sub_sec;
  re57_unity = 1;
  re57_unity has dimensionless;
  re57_unimol = 1;
  re57_unimol has substance;
  re57_tf = 15;
  re57_tf has substance;
  re58_k2 = 0.2;
  re58_k2 has inv_sec;
  re58_Km2 = 6170;
  re58_Km2 has substance;
  re59_k3 = 7.5;
  re59_k3 has inv_sec;
  re59_Km3 = 80.9;
  re59_Km3 has substance;
  re60_k4 = 0.045;
  re60_k4 has inv_sec_sub;
  re60_kr4 = 0.089;
  re60_kr4 has inv_sec;
  re61_k8 = 20;
  re61_k8 has inv_sec;
  re61_Km8 = 80000;
  re61_Km8 has substance;
  re62_k10 = 20;
  re62_k10 has inv_sec;
  re62_Km10 = 80000;
  re62_Km10 has substance;
  re63_k7 = 0.037;
  re63_k7 has inv_sec;
  re63_Km7 = 8800;
  re63_Km7 has substance;
  re64_k9 = 0.04;
  re64_k9 has inv_sec;
  re64_Km9 = 48000;
  re64_Km9 has substance;
  re65_k11 = 0.163;
  re65_k11 has inv_sec;
  re65_Km11 = 48000;
  re65_Km11 has substance;
  re66_k5 = 0.0007;
  re66_k5 has inv_sec_sub;
  re67_k6 = 0.98;
  re67_k6 has inv_sec;
  re68_unitime = 1;
  re68_unitime has sub_sec;

  // Other declarations:
  const default, c1;

  // Unit definitions:
  unit time_unit = second;
  unit substance = 1e-09 mole;
  unit area = metre^2;
  unit length = metre;
  unit volume = litre;
  unit sub_sec = 1e-09 mole / second;
  unit inv_sec = 1 / second;
  unit inv_sec_sub = 1 / (1e-09 mole * second);
  unit nM_inv_s = 1e-9 mole / second;
  unit inv_nM_s = 1 / (1e-9 mole * second);
  unit substance_per_volume = 1e-09 mole / litre;

  // Display Names:
  time_unit is "time";
  c1 is "Cell";
  s14 is "PDK1";
  s15 is "PP2A";
  s16 is "AKT";
  s17 is "PI3P";
  s18 is "PTEN";
  s19 is "PIP2";
  s20 is "p-PI3K";
  s21 is "s3";
  s22 is "PI3K";
  s23 is "Time";
  s24 is "PDK2";
  s25 is "PDK1_cyto";
  s26 is "p-AKT:PI3P";
  s27 is "pp-AKT:PI3P";
  s28 is "AKT:PI3P";
  s119 is "Shear Stress";

  // SBO terms:
  s21.sboTerm = 291

  // CV terms:
  c1 identity "http://identifiers.org/go/GO:0005623"
  s14 hypernym "http://identifiers.org/uniprot/O15530"
  s15 hypernym "http://identifiers.org/go/GO:0000159"
  s16 hypernym "http://identifiers.org/uniprot/P31749"
  s17 hypernym "http://identifiers.org/pubchem.compound/53480352"
  s18 hypernym "http://identifiers.org/uniprot/P60484"
  s19 hypernym "http://identifiers.org/chebi/CHEBI:18348"
  s20 property "http://identifiers.org/psimod/MOD:00696"
  s20 property "http://identifiers.org/interpro/IPR000403"
  s22 property "http://identifiers.org/interpro/IPR000403"
  s24 hypernym "http://identifiers.org/uniprot/Q15119"
  s25 hypernym "http://identifiers.org/uniprot/O15530"
  s25 container "http://identifiers.org/go/GO:0005622"
  s26 part "http://identifiers.org/uniprot/P31749",
           "http://identifiers.org/pubchem.compound/53480352"
  s26 property "http://identifiers.org/psimod/MOD:00696"
  s27 part "http://identifiers.org/uniprot/P31749",
           "http://identifiers.org/pubchem.compound/53480352"
  s27 property "http://identifiers.org/psimod/MOD:00696"
  s28 part "http://identifiers.org/uniprot/P31749",
           "http://identifiers.org/pubchem.compound/53480352"
  s119 container "http://identifiers.org/go/GO:0005576"
end

MODEL1302180004 is "Koo2013 - Shear stress induced AKT and eNOS phosphorylation - Model 2"

MODEL1302180004 model_entity_is "http://identifiers.org/biomodels.db/MODEL1302180004"
MODEL1302180004 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000465"
MODEL1302180004 description "http://identifiers.org/pubmed/23708369"
MODEL1302180004 taxon "http://identifiers.org/taxonomy/9606"
MODEL1302180004 hypernym "http://identifiers.org/reactome/REACT_12443.3"
MODEL1302180004 hypernym "http://identifiers.org/go/GO:0034405"
MODEL1302180004 hypernym "http://identifiers.org/go/GO:0006809",
                         "http://identifiers.org/go/GO:0002537"
