// Created by libAntimony v2.13.0
model *MODEL1302180003()

  // Compartments and Species:
  compartment default, c1, c2;
  substanceOnly species s1 in default, s2 in c2, s3 in c1, s4 in c1, s5 in default;
  substanceOnly species s6 in c1, s7 in c1, s8 in c1, s9 in c1, s10 in c1;
  substanceOnly species s11 in c1, s12 in default, s13 in default, s119 in default;

  // Reactions:
  re3: s4 => s3; -k6*s3*(B_T - s4) + k7*s4;
  re4: s5 => s2; k_CCE*(fracK*Cao/(K3 + Cao) - s2)*(s1 - s2);
  re5: s7 => s6; k1*(R_T - half*R_T*(exp(-s12/tau_I) + exp(-s12/tau_II) + (exp(-s12/tau_I) - exp(-s12/tau_II))*(tau_I + tau_II)/(tau_I - tau_II)))*s3/(K1 + s3);
  re6: s6 => s8; k2*s6;
  re7: s2 => s3; (k3*(k_CICR*s3/(K_CICR + s3))*(s6/(K2 + s6))^3*s2 - k4*(s3/(K3 + s3))^2) + k5*s2*s2;
  re8: s3 => s9; dot_Vhi*s3^4/(K_hi^4 + s3^4);
  re9: s3 => s10; dot_Vex*s3/(K5 + s3);
  re10: s11 => s3; dot_q_inpass;
  re11: s13 => s12; re11_unisec;
  re12: s3 => s9; dot_Vp*s3^2/(K4^2 + s3^2);

  // Species initializations:
  s1 = 1500000/default;
  s1 has substance_per_volume;
  s2 = 2830000/c2;
  s2 has substance_per_volume;
  s3 = 117.2/c1;
  s3 has substance_per_volume;
  s4 = 3870/c1;
  s4 has substance_per_volume;
  s5 = 0;
  s5 has substance_per_volume;
  s6 = 0;
  s6 has substance_per_volume;
  s7 = 0;
  s7 has substance_per_volume;
  s8 = 0;
  s8 has substance_per_volume;
  s9 = 0;
  s9 has substance_per_volume;
  s10 = 0;
  s10 has substance_per_volume;
  s11 = 0;
  s11 has substance_per_volume;
  s12 = 0;
  s12 has substance_per_volume;
  s13 = 0;
  s13 has substance_per_volume;
  s119 = 0;
  s119 has substance_per_volume;

  // Compartment initializations:
  default = 1;
  default has volume;
  c1 = 1;
  c1 has volume;
  c2 = 1;
  c2 has volume;

  // Variable initializations:
  R_T = 44000;
  R_T has dimensionless;
  k1 = 0.0006;
  k1 has sub_sec;
  k2 = 1;
  k2 has inv_sec;
  k3 = 3.32;
  k3 has inv_sec;
  k4 = 2500;
  k4 has sub_sec;
  k5 = 5e-11;
  k5 has inv_sec_sub;
  k6 = 0.05;
  k6 has inv_sec_sub;
  k7 = 150;
  k7 has inv_sec;
  K1 = 0;
  K1 has substance;
  K2 = 200;
  K2 has substance;
  K3 = 150;
  K3 has substance;
  K4 = 80;
  K4 has substance;
  K5 = 321;
  K5 has substance;
  K_hi = 380;
  K_hi has substance;
  k_CICR = 1;
  k_CICR has dimensionless;
  K_CICR = 0;
  K_CICR has substance;
  k_CCE = 0;
  k_CCE has inv_sec_sub;
  B_T = 120000;
  B_T has substance;
  dot_Vp = 815;
  dot_Vp has sub_sec;
  dot_Vex = 9165;
  dot_Vex has sub_sec;
  dot_Vhi = 2380;
  dot_Vhi has sub_sec;
  dot_q_inpass = 3000;
  dot_q_inpass has sub_sec;
  Cao = 100;
  Cao has substance;
  tau_I = 66;
  tau_I has substance;
  tau_II = 0.01;
  tau_II has substance;
  half = 0.5;
  half has dimensionless;
  fracK = 7071067.81;
  fracK has substance;
  re11_unisec = 1;
  re11_unisec has sub_sec;

  // Other declarations:
  const default, c1, c2, R_T, k1, k2, k3, k4, k5, k6, k7, K1, K2, K3, K4;
  const K5, K_hi, k_CICR, K_CICR, k_CCE, B_T, dot_Vp, dot_Vex, dot_Vhi, dot_q_inpass;
  const Cao, tau_I, tau_II, half, fracK;

  // Unit definitions:
  unit time_unit = second;
  unit substance = 1e-09 mole;
  unit area = metre^2;
  unit length = metre;
  unit volume = litre;
  unit sub_sec = 1e-09 mole / second;
  unit inv_sec = 1 / second;
  unit inv_sec_sub = 1 / (1e-09 mole * second);
  unit nM_inv_s = 1e-9 mole / second;
  unit inv_nM_s = 1 / (1e-9 mole * second);
  unit substance_per_volume = 1e-09 mole / litre;

  // Display Names:
  time_unit is "time";
  c1 is "Cell";
  c2 is "ER";
  s1 is "Ca_ex";
  s2 is "Ca_s";
  s3 is "Ca_c";
  s4 is "Ca_B";
  s6 is "IP3";
  s12 is "TimeT";
  s119 is "Shear Stress";
  re3 is "re1";

  // SBO terms:
  s4.sboTerm = 297
  s5.sboTerm = 291
  s7.sboTerm = 291
  s8.sboTerm = 291
  s9.sboTerm = 291
  s10.sboTerm = 291
  s11.sboTerm = 291
  s12.sboTerm = 331
  s13.sboTerm = 291

  // CV terms:
  default identity "http://identifiers.org/go/GO:0005576"
  c1 identity "http://identifiers.org/go/GO:0005623"
  c2 identity "http://identifiers.org/go/GO:0005783"
  s1 identity "http://identifiers.org/chebi/CHEBI:29108"
  s1 container "http://identifiers.org/go/GO:0005576"
  s2 identity "http://identifiers.org/chebi/CHEBI:29108"
  s3 identity "http://identifiers.org/chebi/CHEBI:29108"
  s3 container "http://identifiers.org/go/GO:0005623"
  s4 container "http://identifiers.org/go/GO:0005623"
  s4 part "http://identifiers.org/chebi/CHEBI:29108"
  s6 hypernym "http://identifiers.org/chebi/CHEBI:203600"
end

MODEL1302180003 is "Koo2013 - Shear stress induced calcium influx and eNOS activation - Model 1"

MODEL1302180003 model_entity_is "http://identifiers.org/biomodels.db/MODEL1302180003"
MODEL1302180003 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000464"
MODEL1302180003 description "http://identifiers.org/pubmed/23708369"
MODEL1302180003 taxon "http://identifiers.org/taxonomy/9606"
MODEL1302180003 part "http://identifiers.org/go/GO:0070509"
MODEL1302180003 part "http://identifiers.org/reactome/REACT_12443.3"
MODEL1302180003 hypernym "http://identifiers.org/go/GO:0006809",
                         "http://identifiers.org/go/GO:0002537"
