// Created by libAntimony v2.13.0
model *BIOMD0000000462()

  // Compartments and Species:
  compartment cell;
  substanceOnly species Abeta in cell, AbDim in cell, AbP in cell, $Source in cell;
  substanceOnly species $Sink in cell, Nep in cell;

  // Reactions:
  Abetaproduction: $Source => Abeta; kprod*Source;
  AbetaDegradation: Abeta + Nep => $Sink + Nep; kdeg*Abeta*Nep*0.001;
  AbetaDimerisation: 2 Abeta => AbDim; kdimer*Abeta*(Abeta - 1)*0.5;
  AbetaDedimerisation: AbDim => 2 Abeta; kdedimer*AbDim;
  AbetaPlaqueFormation: 2 AbDim => 4 AbP; kpf*AbDim*(AbDim - 1)*0.5;
  AbetaPlaqueGrowth: Abeta + AbP => 2 AbP; kpg*Abeta*AbP^2/(kpghalf^2 + AbP^2);
  AbetaDisaggregation: AbP => Abeta; kdisagg*AbP;
  NepDegradation: Nep => $Sink; kdegNep*Nep;

  // Species initializations:
  Abeta = 0;
  AbDim = 0;
  AbP = 0;
  Source = 1/cell;
  Sink = 1/cell;
  Nep = 1000/cell;

  // Compartment initializations:
  cell = 1;

  // Variable initializations:
  kprod = 1.86e-05;
  kdeg = 2.1e-05;
  kdimer = 1.1783e-07;
  kdedimer = 8.4655e-06;
  kdisagg = 5.4357e-05;
  kpf = 2.785e-06;
  kpg = 0.00574;
  kpghalf = 4;
  kdegNep = 1.8e-10;

  // Other declarations:
  const cell, kprod, kdeg, kdimer, kdedimer, kdisagg, kpf, kpg, kpghalf, kdegNep;

  // Unit definitions:
  unit substance = item;

  // Display Names:
  Abeta is "AbetaMonomer";
  AbDim is "AbetaDimer";
  AbP is "AbetaPlaque";
  Nep is "Neprilysin";

  // SBO terms:
  Source.sboTerm = 291
  Sink.sboTerm = 291

  // CV terms:
  Abeta hypernym "http://identifiers.org/chebi/CHEBI:64645"
  AbDim hypernym "http://identifiers.org/chebi/CHEBI:64645",
                 "http://identifiers.org/go/GO:0043234"
  AbP hypernym "http://identifiers.org/chebi/CHEBI:64645",
               "http://identifiers.org/bto/BTO:0002774"
  Nep hypernym "http://identifiers.org/uniprot/P08473"
end

BIOMD0000000462 is "Proctor2012 - Role of Amyloid-beta dimers in aggregation formation"

BIOMD0000000462 model_entity_is "http://identifiers.org/biomodels.db/MODEL1202290000"
BIOMD0000000462 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000462"
BIOMD0000000462 description "http://identifiers.org/pubmed/22748062"
BIOMD0000000462 property "http://identifiers.org/doid/DOID:10652"
BIOMD0000000462 hypernym "http://identifiers.org/go/GO:0097242",
                         "http://identifiers.org/go/GO:0070841"
BIOMD0000000462 taxon "http://identifiers.org/taxonomy/9606"
