// Created by libAntimony v2.13.0
model *MODEL1304190000()

  // Compartments and Species:
  compartment cellvolume;
  species IR in cellvolume, IRp in cellvolume, IRins in cellvolume, IRip in cellvolume;
  species IRi in cellvolume, IRS1 in cellvolume, IRS1p in cellvolume, IRS1p307 in cellvolume;
  species IRS1307 in cellvolume, X in cellvolume, Xp in cellvolume, PKB in cellvolume;
  species PKB308p in cellvolume, PKB473p in cellvolume, PKB308p473p in cellvolume;
  species mTORC1 in cellvolume, mTORC1a in cellvolume, mTORC2 in cellvolume;
  species mTORC2a in cellvolume, AS160 in cellvolume, AS160p in cellvolume;
  species GLUT4m in cellvolume, GLUT4 in cellvolume, S6K in cellvolume, S6Kp in cellvolume;
  species S6 in cellvolume, S6p in cellvolume;

  // Assignment Rules:
  measuredIRp := scaleIR*(IRp + IRip);
  measuredIRint := IRi + IRip;
  measuredIRS1p := scaleIRS1*(IRS1p + IRS1p307);
  measuredIRS1307 := scaleIRS1307*(IRS1p307 + IRS1307);
  measuredPKB308p := scalePKB308*(PKB308p + PKB308p473p);
  measuredPKB473p := scalePKB473*(PKB473p + PKB308p473p);
  measuredAS160p := scaleAS160*AS160p;
  measuredmTORC1a := mTORC1a;
  measuredS6Kp := scaleS6K*S6Kp;
  measuredS6p := scaleS6*S6p;
  measuredmTORC2a := mTORC2a;
  glucoseuptake := k8*GLUT4m*gluc + glut1*gluc;

  // Reactions:
  v1a: IR => IRins; IR*k1a*insulin;
  v1basal: IR => IRp; k1basal*IR;
  v1c: IRins => IRp; IRins*k1c;
  v1d: IRp => IRip; IRp*k1d;
  v1e: IRip => IRi; IRip*k1f*Xp;
  v1g: IRp => IR; IRp*k1g;
  v1r: IRi => IR; IRi*k1r;
  v2a: IRS1 => IRS1p; IRS1*k2a*IRip;
  v2b: IRS1p => IRS1; IRS1p*k2b;
  v2c: IRS1p => IRS1p307; IRS1p*k2c*mTORC1a*diabetes;
  v2d: IRS1p307 => IRS1p; IRS1p307*k2d;
  v2f: IRS1p307 => IRS1307; IRS1p307*k2f;
  v2basal: IRS1 => IRS1307; IRS1*k2basal;
  v2g: IRS1307 => IRS1; IRS1307*k2g;
  v3a: X => Xp; X*k3a*IRS1p;
  v3b: Xp => X; Xp*k3b;
  v5a: mTORC1 => mTORC1a; mTORC1*(k5a1*PKB308p473p + k5a2*PKB308p);
  v5b: mTORC1a => mTORC1; mTORC1a*k5b;
  v5c: mTORC2 => mTORC2a; mTORC2*k5c*IRip;
  v5d: mTORC2a => mTORC2; k5d*mTORC2a;
  v4a: PKB => PKB308p; k4a*PKB*IRS1p;
  v4b: PKB308p => PKB; k4b*PKB308p;
  v4c: PKB308p => PKB308p473p; k4c*PKB308p*mTORC2a;
  v4e: PKB473p => PKB308p473p; k4e*PKB473p*IRS1p307;
  v4f: PKB308p473p => PKB473p; k4f*PKB308p473p;
  v4h: PKB473p => PKB; k4h*PKB473p;
  v6f1: AS160 => AS160p; AS160*(k6f1*PKB308p473p + k6f2*PKB473p^n6/(km6^n6 + PKB473p^n6));
  v6b1: AS160p => AS160; AS160p*k6b;
  v7f: GLUT4 => GLUT4m; GLUT4*k7f*AS160p;
  v7b: GLUT4m => GLUT4; GLUT4m*k7b;
  v9f1: S6K => S6Kp; S6K*k9f1*mTORC1a^n9/(km9^n9 + mTORC1a^n9);
  v9b1: S6Kp => S6K; S6Kp*k9b1;
  v9f2: S6 => S6p; S6*k9f2*S6Kp;
  v9b2: S6p => S6; S6p*k9b2;

  // Species initializations:
  IR = 99.8737104842408;
  IRp = 0.00186253217635894;
  IRins = 0;
  IRip = 0.0188430465801578;
  IRi = 0.105583925473107;
  IRS1 = 82.9671997523599;
  IRS1p = 0.00119481841136737;
  IRS1p307 = 0.327454355438396;
  IRS1307 = 16.7041510257561;
  X = 99.9983336594667;
  Xp = 0.00166634053318549;
  PKB = 68.1806649661901;
  PKB308p = 13.2964849666951;
  PKB473p = 16.8171941560617;
  PKB308p473p = 1.70566051030056;
  mTORC1 = 86.5002472240273;
  mTORC1a = 13.4997527759726;
  mTORC2 = 99.8478148461591;
  mTORC2a = 0.152185153840861;
  AS160 = 83.8141018591099;
  AS160p = 16.1858981408903;
  GLUT4m = 26.523878746229;
  GLUT4 = 73.476121253771;
  S6K = 99.2731987219547;
  S6Kp = 0.72680127804522;
  S6 = 92.7596420796038;
  S6p = 7.24035792039603;

  // Compartment initializations:
  cellvolume = 1;

  // Variable initializations:
  diabetes = 1;
  k1a = 0.6331;
  k1basal = 0.03683;
  k1c = 0.8768;
  k1d = 31.01;
  k1f = 1840;
  k1g = 1944;
  k1r = 0.5471;
  k2a = 3.227;
  k2c = 5759;
  k2basal = 0.04228;
  k2b = 3424;
  k2d = 280.8;
  k2f = 2.913;
  k2g = 0.2671;
  k3a = 0.001377;
  k3b = 0.09876;
  k4a = 5790;
  k4b = 34.8;
  k4c = 4.456;
  k4e = 42.84;
  k4f = 143.6;
  k4h = 0.5361;
  k5a1 = 1.842;
  k5a2 = 0.05506;
  k5b = 24.83;
  k5d = 1.06;
  km5 = 2.65;
  k5c = 0.08575;
  k6f1 = 2.652;
  k6f2 = 36.93;
  km6 = 30.54;
  n6 = 2.137;
  k6b = 65.18;
  k7f = 50.98;
  k7b = 2286;
  k8 = 724.2;
  glut1 = 7042;
  k9f1 = 0.1298;
  k9b1 = 0.04441;
  k9f2 = 3.329;
  k9b2 = 31;
  km9 = 5873;
  n9 = 0.9855;
  scaleIR = 5.2022;
  scaleIRS1 = 0.37615;
  scaleIRS1ds = 14.892;
  scaleIRS1307 = 0.058663;
  scalePKB308 = 0.043564;
  scalePKB473 = 0.012996;
  scaleAS160 = 0.026656;
  scaleGLUCOSE = 0.040513;
  scaleS6K = 0.74654;
  scaleS6 = 0.11494;
  gluc = 0.05;
  insulin = 10;

  // Other declarations:
  var measuredIRp, measuredIRint, measuredIRS1p, measuredIRS1307, measuredPKB308p;
  var measuredPKB473p, measuredAS160p, measuredmTORC1a, measuredS6Kp, measuredS6p;
  var measuredmTORC2a, glucoseuptake;
  const cellvolume, diabetes, k1a, k1basal, k1c, k1d, k1f, k1g, k1r, k2a;
  const k2c, k2basal, k2b, k2d, k2f, k2g, k3a, k3b, k4a, k4b, k4c, k4e, k4f;
  const k4h, k5a1, k5a2, k5b, k5d, km5, k5c, k6f1, k6f2, km6, n6, k6b, k7f;
  const k7b, k8, glut1, k9f1, k9b1, k9f2, k9b2, km9, n9, scaleIR, scaleIRS1;
  const scaleIRS1ds, scaleIRS1307, scalePKB308, scalePKB473, scaleAS160, scaleGLUCOSE;
  const scaleS6K, scaleS6, gluc, insulin;

  // SBO terms:
  cellvolume.sboTerm = 290

  // CV terms:
  cellvolume identity "http://identifiers.org/go/GO:0005623"
  IR hypernym "http://identifiers.org/uniprot/P06213"
  IRp hypernym "http://identifiers.org/uniprot/P06213",
               "http://identifiers.org/kegg.compound/C00562"
  IRins part "http://identifiers.org/uniprot/P06213",
             "http://identifiers.org/uniprot/P01308"
  IRip hypernym "http://identifiers.org/uniprot/P06213",
                "http://identifiers.org/kegg.compound/C00562"
  IRi hypernym "http://identifiers.org/uniprot/P06213"
  IRS1 hypernym "http://identifiers.org/uniprot/P35568"
  IRS1p hypernym "http://identifiers.org/uniprot/P35568",
                 "http://identifiers.org/kegg.compound/C00562"
  IRS1p307 hypernym "http://identifiers.org/uniprot/P35568",
                    "http://identifiers.org/kegg.compound/C00562",
                    "http://identifiers.org/psimod/MOD:00046"
  IRS1307 hypernym "http://identifiers.org/uniprot/P35568"
  X hypernym "http://identifiers.org/chebi/CHEBI:36080",
             "http://identifiers.org/fma/FMA:74531"
  Xp hypernym "http://identifiers.org/kegg.compound/C00562",
              "http://identifiers.org/fma/FMA:74531"
  PKB hypernym "http://identifiers.org/uniprot/P31751"
  PKB308p hypernym "http://identifiers.org/uniprot/P31751",
                   "http://identifiers.org/kegg.compound/C00562"
  PKB473p hypernym "http://identifiers.org/uniprot/P31751",
                   "http://identifiers.org/kegg.compound/C00562"
  PKB308p473p hypernym "http://identifiers.org/uniprot/P31751",
                       "http://identifiers.org/kegg.compound/C00562"
  mTORC1 part "http://identifiers.org/uniprot/P42345",
              "http://identifiers.org/uniprot/Q8N122"
  mTORC1a part "http://identifiers.org/uniprot/P42345",
               "http://identifiers.org/uniprot/Q8N122"
  mTORC2 part "http://identifiers.org/uniprot/P42345",
              "http://identifiers.org/uniprot/Q6R327"
  mTORC2a part "http://identifiers.org/uniprot/P42345",
               "http://identifiers.org/uniprot/Q6R327"
  AS160 hypernym "http://identifiers.org/uniprot/O60343"
  AS160p hypernym "http://identifiers.org/uniprot/O60343"
  AS160p property "http://identifiers.org/pato/PATO:0002220"
  GLUT4m hypernym "http://identifiers.org/uniprot/P14672"
  GLUT4m container "http://identifiers.org/go/GO:0005886"
  GLUT4 hypernym "http://identifiers.org/uniprot/P14672"
  S6K hypernym "http://identifiers.org/uniprot/P23443"
  S6Kp hypernym "http://identifiers.org/uniprot/P23443",
                "http://identifiers.org/kegg.compound/C00562"
  S6 hypernym "http://identifiers.org/uniprot/P62753"
  S6p hypernym "http://identifiers.org/uniprot/P62753",
               "http://identifiers.org/kegg.compound/C00562"
end

MODEL1304190000 is "Brännmark2013 - Insulin signalling in human adipocytes (normal condition)"

MODEL1304190000 model_entity_is "http://identifiers.org/biomodels.db/MODEL1304190000"
MODEL1304190000 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000448"
MODEL1304190000 description "http://identifiers.org/pubmed/23400783"
MODEL1304190000 origin "http://identifiers.org/biomodels.db/BIOMD0000000343"
MODEL1304190000 taxon "http://identifiers.org/taxonomy/9606"
MODEL1304190000 hypernym "http://identifiers.org/go/GO:0032869"
MODEL1304190000 property "http://identifiers.org/mamo/MAMO_0000046"
MODEL1304190000 property "http://identifiers.org/doid/DOID:9352"
