// Created by libAntimony v2.13.0
function function_10(MK_P, MKK_PP, MKK_P, MK_PP, MKK, MK, P2, K10b, K5b, K6b, Kse2, K9b, k10b)
  k10b*P2*MK_P/K10b/(1 + MKK_PP/K5b + MKK_P/K6b + MKK/Kse2 + MK/Kse2 + MK_P/K10b + MK_PP/K9b);
end

function_10 is "10"

function function_2(MKKK_P, MKKK, P1, MKK_PP, MKK_P, MKK, Kse1, K2a, K5a, K6a, k2a)
  k2a*MKKK_P*P1/K2a/(1 + MKKK_P/K2a + MKKK/Kse1 + MKK_PP/K5a + MKK_P/K6a + MKK/Kse1);
end

function_2 is "2"

function function_3(k3, MKKK_P, MKK, K3, MKK_P, K4)
  k3*MKKK_P*MKK/K3/(1 + MKK/K3 + MKK_P/K4);
end

function_3 is "3"

function function_6(P1, MKK_P, MKK_PP, MK_P, MK_PP, MKK, MK, k6a, K6a, MKKK, MKKK_P, P2, K6b, K2a, Kse1, K5a, k6b, K5b, Kse2, K10b, K9b)
  k6a*P1*MKK_P/K6a/(1 + MKKK_P/K2a + MKKK/Kse1 + MKK_PP/K5a + MKK_P/K6a + MKK/Kse1) + k6b*P2*MKK_P/K6b/(1 + MKK_PP/K5b + MKK_P/K6b + MKK/Kse2 + MK/Kse2 + MK_P/K10b + MK_PP/K9b);
end

function_6 is "6"

function function_1(MKKK, K1, k1, Sig)
  k1*Sig*MKKK/(K1 + MKKK);
end

function_1 is "1"

function function_4(k4, MKKK_P, MKK_P, K4, MKK, K3)
  k4*MKKK_P*MKK_P/K4/(1 + MKK/K3 + MKK_P/K4);
end

function_4 is "4"

function function_5(MKK_PP, MKK_P, MK_P, MK_PP, P1, MKK, MK, k5a, K5a, MKKK, MKKK_P, k5b, P2, K5b, K6a, Kse1, K2a, K6b, Kse2, K10b, K9b)
  k5a*P1*MKK_PP/K5a/(1 + MKKK_P/K2a + MKKK/Kse1 + MKK_PP/K5a + MKK_P/K6a + MKK/Kse1) + k5b*P2*MKK_PP/K5b/(1 + MKK_PP/K5b + MKK_P/K6b + MKK/Kse2 + MK/Kse2 + MK_P/K10b + MK_PP/K9b);
end

function_5 is "5"

function function_7(k7, MKK_PP, MK, K7, MK_P, K8)
  k7*MKK_PP*MK/K7/(1 + MK/K7 + MK_P/K8);
end

function_7 is "7"

function function_9(MK_PP, MKK_PP, MKK_P, MK_P, MKK, MK, P2, K9b, K5b, K6b, Kse2, K10b, k9b)
  k9b*P2*MK_PP/K9b/(1 + MKK_PP/K5b + MKK_P/K6b + MKK/Kse2 + MK/Kse2 + MK_P/K10b + MK_PP/K9b);
end

function_9 is "9"

function function_8(k7, MKK_PP, MK_P, K8, MK, K7)
  k7*MKK_PP*MK_P/K8/(1 + MK/K7 + MK_P/K8);
end

function_8 is "8"


model *MODEL1204280036()

  // Compartments and Species:
  compartment compartment_1, compartment_2;
  species species_1 in compartment_1, species_2 in compartment_1, species_3 in compartment_1;
  species species_4 in compartment_1, species_5 in compartment_1, species_6 in compartment_1;
  species species_7 in compartment_1, species_8 in compartment_1, species_9 in compartment_1;
  species species_10 in compartment_1, species_11 in compartment_1;

  // Reactions:
  reaction_1: species_1 => species_2; compartment_1*function_1(species_1, parameter_1, reaction_1_k1, species_11);
  reaction_2: species_2 => species_1; compartment_1*function_2(species_2, species_1, species_9, species_5, species_4, species_3, parameter_11, parameter_2, parameter_5, parameter_6, reaction_2_k2a);
  reaction_3: species_3 => species_4; compartment_1*function_3(reaction_3_k3, species_2, species_3, parameter_3, species_4, parameter_4);
  reaction_4: species_4 => species_5; compartment_1*function_4(reaction_4_k4, species_2, species_4, parameter_4, species_3, parameter_3);
  reaction_5: species_5 => species_4; compartment_1*function_5(species_5, species_4, species_7, species_8, species_9, species_3, species_6, reaction_5_k5a, parameter_5, species_1, species_2, reaction_5_k5b, species_10, parameter_13, parameter_6, parameter_11, parameter_2, parameter_14, parameter_12, parameter_10, parameter_9);
  reaction_6: species_4 => species_3; compartment_1*function_6(species_9, species_4, species_5, species_7, species_8, species_3, species_6, reaction_6_k6a, parameter_6, species_1, species_2, species_10, parameter_14, parameter_2, parameter_11, parameter_5, reaction_6_k6b, parameter_13, parameter_12, parameter_10, parameter_9);
  reaction_7: species_6 => species_7; compartment_1*function_7(reaction_7_k7, species_5, species_6, parameter_7, species_7, parameter_8);
  reaction_8: species_7 => species_8; compartment_1*function_8(reaction_8_k7, species_5, species_7, parameter_8, species_6, parameter_7);
  reaction_9: species_8 => species_7; compartment_1*function_9(species_8, species_9, species_4, species_7, species_3, species_6, species_10, parameter_9, parameter_13, parameter_14, parameter_12, parameter_10, reaction_9_k9b);
  reaction_10: species_7 => species_6; compartment_1*function_10(species_7, species_5, species_4, species_8, species_3, species_6, species_10, parameter_10, parameter_13, parameter_14, parameter_12, parameter_9, reaction_10_k10b);

  // Species initializations:
  species_1 = 300;
  species_2 = 0;
  species_3 = 1199.99994221325;
  species_4 = 0;
  species_5 = 0;
  species_6 = 1199.99994221325;
  species_7 = 0;
  species_8 = 0;
  species_9 = 100;
  species_10 = 200;
  species_11 = 20;

  // Compartment initializations:
  compartment_1 = 1;
  compartment_2 = 1;

  // Variable initializations:
  parameter_1 = 100;
  parameter_2 = 54.3;
  parameter_3 = 50.5;
  parameter_4 = 500;
  parameter_5 = 24.3;
  parameter_6 = 108.6;
  parameter_7 = 50.5;
  parameter_8 = 500;
  parameter_9 = 24.3;
  parameter_10 = 108.6;
  parameter_11 = 3e+51;
  parameter_12 = 3e+51;
  parameter_13 = 24.3;
  parameter_14 = 108.6;
  reaction_1_k1 = 1;
  reaction_2_k2a = 0.086;
  reaction_3_k3 = 0.01;
  reaction_4_k4 = 15;
  reaction_5_k5a = 0.092;
  reaction_5_k5b = 0.092;
  reaction_6_k6a = 0.086;
  reaction_6_k6b = 0.086;
  reaction_7_k7 = 0.01;
  reaction_8_k7 = 15;
  reaction_9_k9b = 0.092;
  reaction_10_k10b = 0.086;

  // Other declarations:
  const compartment_1, compartment_2, parameter_1, parameter_2, parameter_3;
  const parameter_4, parameter_5, parameter_6, parameter_7, parameter_8, parameter_9;
  const parameter_10, parameter_11, parameter_12, parameter_13, parameter_14;

  // Unit definitions:
  unit volume = 1e-3 litre;
  unit substance = 1e-9 mole;

  // Display Names:
  compartment_1 is "compartment";
  compartment_2 is "No Name";
  species_1 is "MKKK";
  species_2 is "MKKK_P";
  species_3 is "MKK";
  species_4 is "MKK_P";
  species_5 is "MKK_PP";
  species_6 is "MK";
  species_7 is "MK_P";
  species_8 is "MK_PP";
  species_9 is "P1";
  species_10 is "P2";
  species_11 is "Sig";
  parameter_1 is "K1";
  parameter_2 is "K2a";
  parameter_3 is "K3";
  parameter_4 is "K4";
  parameter_5 is "K5a";
  parameter_6 is "K6a";
  parameter_7 is "K7";
  parameter_8 is "K8";
  parameter_9 is "K9b";
  parameter_10 is "K10b";
  parameter_11 is "Kse1";
  parameter_12 is "Kse2";
  parameter_13 is "K5b";
  parameter_14 is "K6b";
  reaction_1 is "1";
  reaction_2 is "2";
  reaction_3 is "3";
  reaction_4 is "4";
  reaction_5 is "5";
  reaction_6 is "6";
  reaction_7 is "7";
  reaction_8 is "8";
  reaction_9 is "9";
  reaction_10 is "10";

  // CV terms:
  compartment_1 hypernym "http://identifiers.org/go/GO:0005623"
  species_1 hypernym "http://identifiers.org/uniprot/P04049"
  species_2 hypernym "http://identifiers.org/uniprot/P04049",
                     "http://identifiers.org/kegg.compound/C00562"
  species_3 hypernym "http://identifiers.org/uniprot/Q02750"
  species_4 hypernym "http://identifiers.org/uniprot/Q02750",
                     "http://identifiers.org/kegg.compound/C00562"
  species_5 hypernym "http://identifiers.org/uniprot/Q02750",
                     "http://identifiers.org/kegg.compound/C00562"
  species_6 hypernym "http://identifiers.org/uniprot/P27361"
  species_7 hypernym "http://identifiers.org/uniprot/P27361",
                     "http://identifiers.org/kegg.compound/C00562"
  species_8 hypernym "http://identifiers.org/uniprot/P27361",
                     "http://identifiers.org/kegg.compound/C00562"
  species_9 hypernym "http://identifiers.org/uniprot/P51452"
  species_10 hypernym "http://identifiers.org/uniprot/P51452"
  species_11 hypernym "http://identifiers.org/uniprot/P61225"
  reaction_1 hypernym "http://identifiers.org/go/GO:0016310"
  reaction_2 hypernym "http://identifiers.org/go/GO:0016311"
  reaction_3 hypernym "http://identifiers.org/go/GO:0016310"
  reaction_4 hypernym "http://identifiers.org/go/GO:0016310"
  reaction_5 hypernym "http://identifiers.org/go/GO:0016311"
  reaction_6 hypernym "http://identifiers.org/go/GO:0016311"
  reaction_7 hypernym "http://identifiers.org/go/GO:0016310"
  reaction_8 hypernym "http://identifiers.org/go/GO:0016310"
  reaction_9 hypernym "http://identifiers.org/go/GO:0016311"
  reaction_10 hypernym "http://identifiers.org/go/GO:0016311"
end

MODEL1204280036 is "Sarma2012 - Interaction topologies of MAPK cascade (M4_K2_QSS_USEQ)"

MODEL1204280036 model_entity_is "http://identifiers.org/biomodels.db/MODEL1204280036"
MODEL1204280036 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000432"
MODEL1204280036 description "http://identifiers.org/pubmed/22748295"
MODEL1204280036 origin "http://identifiers.org/pubmed/19897477"
MODEL1204280036 taxon "http://identifiers.org/taxonomy/131567"
MODEL1204280036 hypernym "http://identifiers.org/go/GO:0000165"
