// Created by libAntimony v2.13.0
model *Abell2011_CalciumSignaling_WithAdaptation()

  // Compartments and Species:
  compartment cytosol, outside, mitochondria, ER_store;
  species CaI in cytosol, IP3 in cytosol, g in cytosol, mwaf195932_a72c_4552_8cf2_b349b15d39c4 in cytosol;
  species mw0ebc76ad_49d7_4845_8f88_04d443fbe7f3 in cytosol, mw7cb2644a_384a_4bbb_93fd_fd686e01d7cb in cytosol;
  species mwd6b792d8_c983_42c1_b3bc_2494d6a3363e in outside, mw013a7c64_a9ec_483c_b3b8_ed658337ee95 in mitochondria;
  species CaS in ER_store;

  // Reactions:
  kPLC:  => IP3; R*CaI;
  JPump: CaI => CaS; mw0ebc76ad_49d7_4845_8f88_04d443fbe7f3*CaI^2/(CaI^2 + k2^2);
  JChannel: CaS => CaI; (1 - mwd8bf5d8f_ad00_4119_bde1_91015ef2cd7c)*(L + ((1 - g)*A*IP3^2/(IP3^2 + mw92b257b7_00af_4fd6_a11b_8e4655a4ba65^2))*CaI^2/(CaI^2 + mw78dd80b8_e003_4c62_81d1_547d001767af^2))*CaS;
  kPhosphatase: IP3 => ; D*IP3;
  inhibition_parameter1:  => g; (E*CaI^4/(CaI^4 + mwf998b218_be11_4aa4_81ae_41141861fb42^4))*(1 - g);
  inhibition_parameter2: g => ; F*g;
  mwbdcd6a40_1ae7_4c86_a99f_1fba0b8beaf7:  => CaI; mw7cb2644a_384a_4bbb_93fd_fd686e01d7cb*(mw0ad64e84_bb75_4be4_a9c3_2d4741b0f45f + mwfe8e89cf_3c67_4dd5_939e_b4cfee2e0778^8/(CaS^8 + mwfe8e89cf_3c67_4dd5_939e_b4cfee2e0778^8));
  mw530793e3_76b2_4483_be11_e94364306712: CaI => ; mwaf195932_a72c_4552_8cf2_b349b15d39c4*CaI^2/(CaI^2 + mw3a93c3a6_623a_44fe_84e9_a47823defd1f^2);
  mw5658298a_d96a_4b97_9a4f_6f06dad35824:  => mwaf195932_a72c_4552_8cf2_b349b15d39c4; mwd3b36919_202a_4fed_a3c8_1a3a60594404*mwfbff577a_4e9c_40fe_8777_eb0ceade28c9*mwd21d3f76_d133_4053_8e44_02a538657e0a*CaI^4/((mwd3b36919_202a_4fed_a3c8_1a3a60594404 - 1)*0.05^4 + CaI^4);
  mw700bd02b_9fc4_47e7_864a_967c03874dd6: mwaf195932_a72c_4552_8cf2_b349b15d39c4 => ; mwaf195932_a72c_4552_8cf2_b349b15d39c4*mwfbff577a_4e9c_40fe_8777_eb0ceade28c9;
  mw06f8fde4_d97b_4d5f_b71e_d93aa53e9932:  => mw0ebc76ad_49d7_4845_8f88_04d443fbe7f3; (1/mwd3b36919_202a_4fed_a3c8_1a3a60594404)*B*mwfbff577a_4e9c_40fe_8777_eb0ceade28c9*((mwd3b36919_202a_4fed_a3c8_1a3a60594404 - 1)*2^4 + CaS^4)/CaS^4;
  mw8021d532_dd9b_4e34_a865_c2bb1689b0b5:  => mw7cb2644a_384a_4bbb_93fd_fd686e01d7cb; ((1/(mwd3b36919_202a_4fed_a3c8_1a3a60594404*mwd3b36919_202a_4fed_a3c8_1a3a60594404))*mw004dcb62_da5f_41c7_a7bd_033574894f48*mwfbff577a_4e9c_40fe_8777_eb0ceade28c9*((mwd3b36919_202a_4fed_a3c8_1a3a60594404 - 1)*2^2 + CaS^2)/CaS^2)*((mwd3b36919_202a_4fed_a3c8_1a3a60594404 - 1)*0.05^2 + CaI^2)/CaI^2;
  mw1f122e51_99cb_4a32_a12e_4c2921920a17: mw7cb2644a_384a_4bbb_93fd_fd686e01d7cb => ; mw7cb2644a_384a_4bbb_93fd_fd686e01d7cb*mwfbff577a_4e9c_40fe_8777_eb0ceade28c9;
  mw89d547e1_8d48_4cd2_ba3d_e4390294089d: mw0ebc76ad_49d7_4845_8f88_04d443fbe7f3 => ; mw0ebc76ad_49d7_4845_8f88_04d443fbe7f3*mwfbff577a_4e9c_40fe_8777_eb0ceade28c9;
  mwa61047ec_49c1_47b2_b78e_4d84a33d432a: CaI => mw013a7c64_a9ec_483c_b3b8_ed658337ee95; mwa3072851_e3e4_4767_ac41_49fa7c0de7a7*CaI^4/(CaI^4 + mwe3841c25_6042_49c2_9feb_90cbf6751167^4);
  ERtoMito: CaS => mw013a7c64_a9ec_483c_b3b8_ed658337ee95; mwd8bf5d8f_ad00_4119_bde1_91015ef2cd7c*(L + ((1 - g)*A*IP3^2/(IP3^2 + mw92b257b7_00af_4fd6_a11b_8e4655a4ba65^2))*CaI^2/(CaI^2 + mw78dd80b8_e003_4c62_81d1_547d001767af^2))*CaS;
  mw1c50c3d1_dab9_423a_8373_6a4c75479b54: mw013a7c64_a9ec_483c_b3b8_ed658337ee95 => CaI; mw219cf65d_18cc_4f7e_ab5a_5b87cda6fc43*mw013a7c64_a9ec_483c_b3b8_ed658337ee95/(mw013a7c64_a9ec_483c_b3b8_ed658337ee95 + 0.01);

  // Species initializations:
  CaI = 0.05/cytosol;
  IP3 = 0;
  g = 0.002/cytosol;
  mwaf195932_a72c_4552_8cf2_b349b15d39c4 = 0.013/cytosol;
  mw0ebc76ad_49d7_4845_8f88_04d443fbe7f3 = 0.266/cytosol;
  mw7cb2644a_384a_4bbb_93fd_fd686e01d7cb = 0.02/cytosol;
  mwd6b792d8_c983_42c1_b3bc_2494d6a3363e = 1000/outside;
  mw013a7c64_a9ec_483c_b3b8_ed658337ee95 = 0;
  CaS = 2/ER_store;

  // Compartment initializations:
  cytosol = 1;
  outside = 1;
  mitochondria = 1;
  ER_store = 1;

  // Variable initializations:
  A = 3;
  B = 0.266;
  D = 2;
  E = 5;
  F = 0.018;
  k2 = 0.175;
  L = 0.01;
  R = 1;
  mw92b257b7_00af_4fd6_a11b_8e4655a4ba65 = 0.175;
  mw0ad64e84_bb75_4be4_a9c3_2d4741b0f45f = 0.0346;
  mwfe8e89cf_3c67_4dd5_939e_b4cfee2e0778 = 1;
  mw004dcb62_da5f_41c7_a7bd_033574894f48 = 0.02;
  mw78dd80b8_e003_4c62_81d1_547d001767af = 0.13;
  mw3a93c3a6_623a_44fe_84e9_a47823defd1f = 0.2;
  mwd21d3f76_d133_4053_8e44_02a538657e0a = 0.013;
  mwf998b218_be11_4aa4_81ae_41141861fb42 = 1;
  mwfbff577a_4e9c_40fe_8777_eb0ceade28c9 = 1e-06;
  mwd8bf5d8f_ad00_4119_bde1_91015ef2cd7c = 0.03;
  mwe3841c25_6042_49c2_9feb_90cbf6751167 = 0.6;
  mw219cf65d_18cc_4f7e_ab5a_5b87cda6fc43 = 0.005;
  mwa3072851_e3e4_4767_ac41_49fa7c0de7a7 = 0.03;
  mwd3b36919_202a_4fed_a3c8_1a3a60594404 = 8;

  // Other declarations:
  var cytosol, ER_store;
  const outside, mitochondria, A, B, D, E, F, k2, L, R, mw92b257b7_00af_4fd6_a11b_8e4655a4ba65;
  const mw0ad64e84_bb75_4be4_a9c3_2d4741b0f45f, mwfe8e89cf_3c67_4dd5_939e_b4cfee2e0778;
  const mw004dcb62_da5f_41c7_a7bd_033574894f48, mw78dd80b8_e003_4c62_81d1_547d001767af;
  const mw3a93c3a6_623a_44fe_84e9_a47823defd1f, mwd21d3f76_d133_4053_8e44_02a538657e0a;
  const mwf998b218_be11_4aa4_81ae_41141861fb42, mwfbff577a_4e9c_40fe_8777_eb0ceade28c9;
  const mwd8bf5d8f_ad00_4119_bde1_91015ef2cd7c, mwe3841c25_6042_49c2_9feb_90cbf6751167;
  const mw219cf65d_18cc_4f7e_ab5a_5b87cda6fc43, mwa3072851_e3e4_4767_ac41_49fa7c0de7a7;
  const mwd3b36919_202a_4fed_a3c8_1a3a60594404;

  // Display Names:
  outside is "Outside";
  mitochondria is "mito";
  mwaf195932_a72c_4552_8cf2_b349b15d39c4 is "PMCA";
  mw0ebc76ad_49d7_4845_8f88_04d443fbe7f3 is "SERCA";
  mw7cb2644a_384a_4bbb_93fd_fd686e01d7cb is "STIM";
  mwd6b792d8_c983_42c1_b3bc_2494d6a3363e is "CaO";
  mw013a7c64_a9ec_483c_b3b8_ed658337ee95 is "CaM";
  A is "IP3R";
  B is "SERCA0";
  D is "IP3degradation";
  E is "IP3Rinhibition";
  F is "IP3Rrecovery";
  k2 is "kSERCA";
  L is "ERleak";
  mw92b257b7_00af_4fd6_a11b_8e4655a4ba65 is "kIP3R";
  mw0ad64e84_bb75_4be4_a9c3_2d4741b0f45f is "PMleak";
  mwfe8e89cf_3c67_4dd5_939e_b4cfee2e0778 is "kSTIM";
  mw004dcb62_da5f_41c7_a7bd_033574894f48 is "STIM0";
  mw78dd80b8_e003_4c62_81d1_547d001767af is "kIP3Rca";
  mw3a93c3a6_623a_44fe_84e9_a47823defd1f is "kPMCA";
  mwd21d3f76_d133_4053_8e44_02a538657e0a is "PMCA0";
  mwf998b218_be11_4aa4_81ae_41141861fb42 is "kG";
  mwfbff577a_4e9c_40fe_8777_eb0ceade28c9 is "ProtDeg";
  mwd8bf5d8f_ad00_4119_bde1_91015ef2cd7c is "DirTransf";
  mwe3841c25_6042_49c2_9feb_90cbf6751167 is "kUnip";
  mw219cf65d_18cc_4f7e_ab5a_5b87cda6fc43 is "MitNaCaEx";
  mwa3072851_e3e4_4767_ac41_49fa7c0de7a7 is "Uniport";
  mwd3b36919_202a_4fed_a3c8_1a3a60594404 is "cr";
  kPLC is "PLC: Receptor and Ca2+ regulated IP3 production";
  JPump is "SERCA: Pumps Ca2+ into ER Ca2+ stores";
  JChannel is "IP3R: IP3 and Ca2+ regulated Ca2+ channel,  plus leak";
  kPhosphatase is "IP3 phosphatase:  Degradation of IP3";
  inhibition_parameter1 is "Inhibition of IP3R (mechanism not well understood)";
  inhibition_parameter2 is "Recovery of IP3R from Ca2+ iinhibition when Ca2+ drops";
  mwbdcd6a40_1ae7_4c86_a99f_1fba0b8beaf7 is "Regulation of Orai by STIM, plus leak";
  mw530793e3_76b2_4483_be11_e94364306712 is "PMCA:  Pumps Ca2+ across PM out of cell";
  mw5658298a_d96a_4b97_9a4f_6f06dad35824 is "PMCA synthesis";
  mw700bd02b_9fc4_47e7_864a_967c03874dd6 is "PMCA degradation";
  mw06f8fde4_d97b_4d5f_b71e_d93aa53e9932 is "SERCA synthesis";
  mw8021d532_dd9b_4e34_a865_c2bb1689b0b5 is "STIM/Orai synthesis";
  mw1f122e51_99cb_4a32_a12e_4c2921920a17 is "STIM/Orai degradation";
  mw89d547e1_8d48_4cd2_ba3d_e4390294089d is "SERCA degradation";
  mwa61047ec_49c1_47b2_b78e_4d84a33d432a is "CytToMito";
  mw1c50c3d1_dab9_423a_8373_6a4c75479b54 is "MitoToCytosol";

  // SBO terms:
  cytosol.sboTerm = 290
  outside.sboTerm = 290
  mitochondria.sboTerm = 290
  ER_store.sboTerm = 290
  CaI.sboTerm = 247
  IP3.sboTerm = 247
  mwaf195932_a72c_4552_8cf2_b349b15d39c4.sboTerm = 242
  mw0ebc76ad_49d7_4845_8f88_04d443fbe7f3.sboTerm = 242
  mw7cb2644a_384a_4bbb_93fd_fd686e01d7cb.sboTerm = 252
  mwd6b792d8_c983_42c1_b3bc_2494d6a3363e.sboTerm = 247
  mw013a7c64_a9ec_483c_b3b8_ed658337ee95.sboTerm = 247
  CaS.sboTerm = 247

  // CV terms:
  cytosol hypernym "http://identifiers.org/obo.go/GO:0005829"
  outside hypernym "http://identifiers.org/obo.go/GO:0005576"
  mitochondria hypernym "http://identifiers.org/obo.go/GO:0005739"
  ER_store hypernym "http://identifiers.org/obo.go/GO:0005783"
  CaI hypernym "http://identifiers.org/obo.chebi/CHEBI:29108",
               "http://identifiers.org/kegg.compound/C00076"
  IP3 hypernym "http://identifiers.org/obo.chebi/CHEBI:16595",
               "http://identifiers.org/kegg.compound/C01255"
  g hypernym "http://identifiers.org/obo.go/GO:0019855"
  mwaf195932_a72c_4552_8cf2_b349b15d39c4 hypernym "http://identifiers.org/uniprot/Q9V4C7"
  mw0ebc76ad_49d7_4845_8f88_04d443fbe7f3 hypernym "http://identifiers.org/uniprot/P22700"
  mw7cb2644a_384a_4bbb_93fd_fd686e01d7cb hypernym "http://identifiers.org/uniprot/P83094"
  mwd6b792d8_c983_42c1_b3bc_2494d6a3363e hypernym "http://identifiers.org/obo.chebi/CHEBI:29108",
                                                  "http://identifiers.org/kegg.compound/C00076"
  mw013a7c64_a9ec_483c_b3b8_ed658337ee95 hypernym "http://identifiers.org/obo.chebi/CHEBI:29108",
                                                  "http://identifiers.org/kegg.compound/C00076"
  CaS hypernym "http://identifiers.org/obo.chebi/CHEBI:29108",
               "http://identifiers.org/kegg.compound/C00076"
  kPLC hypernym "http://identifiers.org/obo.go/GO:0032959"
  JPump hypernym "http://identifiers.org/obo.go/GO:0060401"
  JChannel hypernym "http://identifiers.org/obo.go/GO:0051209"
  kPhosphatase hypernym "http://identifiers.org/obo.go/GO:0032961"
  inhibition_parameter1 hypernym "http://identifiers.org/obo.go/GO:0031586"
  inhibition_parameter2 hypernym "http://identifiers.org/obo.go/GO:0031587"
  mwbdcd6a40_1ae7_4c86_a99f_1fba0b8beaf7 hypernym "http://identifiers.org/obo.go/GO:0032234"
  mw530793e3_76b2_4483_be11_e94364306712 hypernym "http://identifiers.org/obo.go/GO:0006816"
  mw5658298a_d96a_4b97_9a4f_6f06dad35824 hypernym "http://identifiers.org/obo.go/GO:0009058"
  mw700bd02b_9fc4_47e7_864a_967c03874dd6 hypernym "http://identifiers.org/obo.go/GO:0009056"
  mw06f8fde4_d97b_4d5f_b71e_d93aa53e9932 hypernym "http://identifiers.org/obo.go/GO:0009058"
  mw8021d532_dd9b_4e34_a865_c2bb1689b0b5 hypernym "http://identifiers.org/obo.go/GO:0009058"
  mw1f122e51_99cb_4a32_a12e_4c2921920a17 hypernym "http://identifiers.org/obo.go/GO:0009056"
  mw89d547e1_8d48_4cd2_ba3d_e4390294089d hypernym "http://identifiers.org/obo.go/GO:0009056"
  mwa61047ec_49c1_47b2_b78e_4d84a33d432a hypernym "http://identifiers.org/obo.go/GO:0006851"
  ERtoMito hypernym "http://identifiers.org/obo.go/GO:0006889",
                    "http://identifiers.org/obo.go/GO:0006851"
  mw1c50c3d1_dab9_423a_8373_6a4c75479b54 hypernym "http://identifiers.org/obo.go/GO:0006851"
end

Abell2011_CalciumSignaling_WithAdaptation is "Abell2011_CalciumSignaling_WithAdaptation"

Abell2011_CalciumSignaling_WithAdaptation model_entity_is "http://identifiers.org/biomodels.db/MODEL1108050001"
Abell2011_CalciumSignaling_WithAdaptation model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000355"
Abell2011_CalciumSignaling_WithAdaptation description "http://identifiers.org/pubmed/21844332"
Abell2011_CalciumSignaling_WithAdaptation taxon "http://identifiers.org/taxonomy/7215"
Abell2011_CalciumSignaling_WithAdaptation hypernym "http://identifiers.org/obo.go/GO:0019722"
