// Created by libAntimony v2.13.0
model *Proctor2010_UCHL1_ProteinAggregation()

  // Compartments and Species:
  compartment cytosol;
  substanceOnly species NatP in cytosol, MisP in cytosol, Ub in cytosol, E1 in cytosol;
  substanceOnly species E2 in cytosol, E3 in cytosol, E3_MisP in cytosol;
  substanceOnly species DUB in cytosol, Proteasome in cytosol, ROS in cytosol;
  substanceOnly species E1_Ub in cytosol, E2_Ub in cytosol, E3_MisP_Ub in cytosol;
  substanceOnly species E3_MisP_Ub2 in cytosol, E3_MisP_Ub3 in cytosol, E3_MisP_Ub4 in cytosol;
  substanceOnly species E3_MisP_Ub5 in cytosol, E3_MisP_Ub6 in cytosol, E3_MisP_Ub7 in cytosol;
  substanceOnly species E3_MisP_Ub8 in cytosol, MisP_Ub4_Proteasome in cytosol;
  substanceOnly species MisP_Ub5_Proteasome in cytosol, MisP_Ub6_Proteasome in cytosol;
  substanceOnly species MisP_Ub7_Proteasome in cytosol, MisP_Ub8_Proteasome in cytosol;
  substanceOnly species E3_MisP_Ub_DUB in cytosol, E3_MisP_Ub2_DUB in cytosol;
  substanceOnly species E3_MisP_Ub3_DUB in cytosol, E3_MisP_Ub4_DUB in cytosol;
  substanceOnly species E3_MisP_Ub5_DUB in cytosol, E3_MisP_Ub6_DUB in cytosol;
  substanceOnly species E3_MisP_Ub7_DUB in cytosol, E3_MisP_Ub8_DUB in cytosol;
  substanceOnly species AggP1 in cytosol, AggP2 in cytosol, AggP3 in cytosol;
  substanceOnly species AggP4 in cytosol, AggP5 in cytosol, SeqAggP in cytosol;
  substanceOnly species AggP_Proteasome in cytosol, $ATP in cytosol, $ADP in cytosol;
  substanceOnly species $AMP in cytosol, UCHL1 in cytosol, UCHL1_Proteasome in cytosol;
  substanceOnly species UCHL1_damaged_Proteasome in cytosol, Lysosome in cytosol;
  substanceOnly species UCHL1_damaged in cytosol, Lamp2a in cytosol, Lamp2a_UCHL1_damaged in cytosol;
  substanceOnly species Ub_UCHL1 in cytosol, SUB in cytosol, SUB_misfolded in cytosol;
  substanceOnly species E3SUB in cytosol, E3SUB_SUB_misfolded in cytosol;
  substanceOnly species E3SUB_SUB_misfolded_Ub in cytosol, E3SUB_SUB_misfolded_Ub2 in cytosol;
  substanceOnly species E3SUB_SUB_misfolded_Ub3 in cytosol, E3SUB_SUB_misfolded_Ub4 in cytosol;
  substanceOnly species E3SUB_SUB_misfolded_Ub5 in cytosol, E3SUB_SUB_misfolded_Ub6 in cytosol;
  substanceOnly species E3SUB_SUB_misfolded_Ub7 in cytosol, E3SUB_SUB_misfolded_Ub8 in cytosol;
  substanceOnly species E3SUB_SUB_misfolded_Ub_UCHL1 in cytosol, E3SUB_SUB_misfolded_Ub2_UCHL1 in cytosol;
  substanceOnly species E3SUB_SUB_misfolded_Ub3_UCHL1 in cytosol, E3SUB_SUB_misfolded_Ub4_UCHL1 in cytosol;
  substanceOnly species E3SUB_SUB_misfolded_Ub5_UCHL1 in cytosol, E3SUB_SUB_misfolded_Ub6_UCHL1 in cytosol;
  substanceOnly species E3SUB_SUB_misfolded_Ub7_UCHL1 in cytosol, E3SUB_SUB_misfolded_Ub8_UCHL1 in cytosol;
  substanceOnly species SUB_misfolded_Ub4_Proteasome in cytosol, SUB_misfolded_Ub5_Proteasome in cytosol;
  substanceOnly species SUB_misfolded_Ub6_Proteasome in cytosol, SUB_misfolded_Ub7_Proteasome in cytosol;
  substanceOnly species SUB_misfolded_Ub8_Proteasome in cytosol, asyn in cytosol;
  substanceOnly species asyn_Proteasome in cytosol, asyn_Lamp2a in cytosol;
  substanceOnly species asyn_dam in cytosol, Parkin in cytosol, Parkin_asyn_dam in cytosol;
  substanceOnly species Parkin_asyn_dam_Ub in cytosol, Parkin_asyn_dam_Ub2 in cytosol;
  substanceOnly species Parkin_asyn_dam_Ub3 in cytosol, Parkin_asyn_dam_Ub4 in cytosol;
  substanceOnly species Parkin_asyn_dam_Ub5 in cytosol, Parkin_asyn_dam_Ub6 in cytosol;
  substanceOnly species Parkin_asyn_dam_Ub7 in cytosol, Parkin_asyn_dam_Ub8 in cytosol;
  substanceOnly species Parkin_asyn_dam_Ub_DUB in cytosol, Parkin_asyn_dam_Ub2_DUB in cytosol;
  substanceOnly species Parkin_asyn_dam_Ub3_DUB in cytosol, Parkin_asyn_dam_Ub4_DUB in cytosol;
  substanceOnly species Parkin_asyn_dam_Ub5_DUB in cytosol, Parkin_asyn_dam_Ub6_DUB in cytosol;
  substanceOnly species Parkin_asyn_dam_Ub7_DUB in cytosol, Parkin_asyn_dam_Ub8_DUB in cytosol;
  substanceOnly species asyn_dam_Ub4_Proteasome in cytosol, asyn_dam_Ub5_Proteasome in cytosol;
  substanceOnly species asyn_dam_Ub6_Proteasome in cytosol, asyn_dam_Ub7_Proteasome in cytosol;
  substanceOnly species asyn_dam_Ub8_Proteasome in cytosol, AggA1 in cytosol;
  substanceOnly species AggA2 in cytosol, AggA3 in cytosol, AggA4 in cytosol;
  substanceOnly species AggA5 in cytosol, AggD1 in cytosol, AggD2 in cytosol;
  substanceOnly species AggD3 in cytosol, AggD4 in cytosol, AggD5 in cytosol;
  substanceOnly species AggU1 in cytosol, AggU2 in cytosol, AggU3 in cytosol;
  substanceOnly species AggU4 in cytosol, AggU5 in cytosol, AggS1 in cytosol;
  substanceOnly species AggS2 in cytosol, AggS3 in cytosol, AggS4 in cytosol;
  substanceOnly species AggS5 in cytosol, $Source in cytosol, $Sink in cytosol;
  substanceOnly species aggasyn in cytosol, aggasyndam in cytosol, aggParkin in cytosol;
  substanceOnly species aggUb in cytosol, aggE3 in cytosol, aggDUB in cytosol;
  substanceOnly species aggMisP in cytosol, aggUchl1 in cytosol, aggUchl1dam in cytosol;
  substanceOnly species aggSUB in cytosol, upregUb in cytosol;

  // Assignment Rules:
  Tot_MisP := E3_MisP + E3_MisP_Ub + E3_MisP_Ub_DUB + E3_MisP_Ub2 + E3_MisP_Ub2_DUB + E3_MisP_Ub3 + E3_MisP_Ub3_DUB + E3_MisP_Ub4 + E3_MisP_Ub4_DUB + E3_MisP_Ub5 + E3_MisP_Ub5_DUB + E3_MisP_Ub6 + E3_MisP_Ub6_DUB + E3_MisP_Ub7 + E3_MisP_Ub7_DUB + E3_MisP_Ub8 + E3_MisP_Ub8_DUB + MisP + MisP_Ub4_Proteasome + MisP_Ub5_Proteasome + MisP_Ub6_Proteasome + MisP_Ub7_Proteasome + MisP_Ub8_Proteasome;
  Tot_Protein := Tot_MisP + NatP;
  Ub_Conjugates := aggUb + 4*asyn_dam_Ub4_Proteasome + 5*asyn_dam_Ub5_Proteasome + 6*asyn_dam_Ub6_Proteasome + 7*asyn_dam_Ub7_Proteasome + 8*asyn_dam_Ub8_Proteasome + E1_Ub + E2_Ub + E3_MisP_Ub + E3_MisP_Ub_DUB + 2*E3_MisP_Ub2 + 2*E3_MisP_Ub2_DUB + 3*E3_MisP_Ub3 + 3*E3_MisP_Ub3_DUB + 4*E3_MisP_Ub4 + 4*E3_MisP_Ub4_DUB + 5*E3_MisP_Ub5 + 5*E3_MisP_Ub5_DUB + 6*E3_MisP_Ub6 + 6*E3_MisP_Ub6_DUB + 7*E3_MisP_Ub7 + 7*E3_MisP_Ub7_DUB + 8*E3_MisP_Ub8 + 8*E3_MisP_Ub8_DUB + E3SUB_SUB_misfolded_Ub + E3SUB_SUB_misfolded_Ub_UCHL1 + 2*E3SUB_SUB_misfolded_Ub2 + 2*E3SUB_SUB_misfolded_Ub2_UCHL1 + 3*E3SUB_SUB_misfolded_Ub3 + 3*E3SUB_SUB_misfolded_Ub3_UCHL1 + 4*E3SUB_SUB_misfolded_Ub4 + 4*E3SUB_SUB_misfolded_Ub4_UCHL1 + 5*E3SUB_SUB_misfolded_Ub5 + 5*E3SUB_SUB_misfolded_Ub5_UCHL1 + 6*E3SUB_SUB_misfolded_Ub6 + 6*E3SUB_SUB_misfolded_Ub6_UCHL1 + 7*E3SUB_SUB_misfolded_Ub7 + 7*E3SUB_SUB_misfolded_Ub7_UCHL1 + 8*E3SUB_SUB_misfolded_Ub8 + 8*E3SUB_SUB_misfolded_Ub8_UCHL1 + E3SUB_SUB_misfolded_Ub_UCHL1 + 4*MisP_Ub4_Proteasome + 5*MisP_Ub5_Proteasome + 6*MisP_Ub6_Proteasome + 7*MisP_Ub7_Proteasome + 8*MisP_Ub8_Proteasome + Parkin_asyn_dam_Ub + Parkin_asyn_dam_Ub_DUB + 2*Parkin_asyn_dam_Ub2 + 2*Parkin_asyn_dam_Ub2_DUB + 3*Parkin_asyn_dam_Ub3 + 3*Parkin_asyn_dam_Ub3_DUB + 4*Parkin_asyn_dam_Ub4 + 4*Parkin_asyn_dam_Ub4_DUB + 5*Parkin_asyn_dam_Ub5 + 5*Parkin_asyn_dam_Ub5_DUB + 6*Parkin_asyn_dam_Ub6 + 6*Parkin_asyn_dam_Ub6_DUB + 7*Parkin_asyn_dam_Ub7 + 7*Parkin_asyn_dam_Ub7_DUB + 8*Parkin_asyn_dam_Ub8 + 8*Parkin_asyn_dam_Ub8_DUB + 4*SUB_misfolded_Ub4_Proteasome + 5*SUB_misfolded_Ub5_Proteasome + 6*SUB_misfolded_Ub6_Proteasome + 7*SUB_misfolded_Ub7_Proteasome + 8*SUB_misfolded_Ub8_Proteasome + Ub_UCHL1 + upregUb;
  Tot_Ub := Ub_Conjugates + Ub;
  AggP := AggA1 + AggA2 + AggA3 + AggA4 + AggA5 + aggasyn + aggasyndam + AggD1 + AggD2 + AggD3 + AggD4 + AggD5 + aggDUB + aggE3 + aggMisP + AggP1 + AggP2 + AggP3 + AggP4 + AggP5 + aggParkin + AggS1 + AggS2 + AggS3 + AggS4 + AggS5 + aggSUB + AggU1 + AggU2 + AggU3 + AggU4 + AggU5 + aggUb + aggUchl1 + aggUchl1dam;
  Tot_asyn_dam := asyn_dam + asyn_dam_Ub4_Proteasome + asyn_dam_Ub5_Proteasome + asyn_dam_Ub6_Proteasome + asyn_dam_Ub7_Proteasome + asyn_dam_Ub8_Proteasome + asyn_dam_Ub4_Proteasome + Parkin_asyn_dam + Parkin_asyn_dam_Ub + Parkin_asyn_dam_Ub_DUB + Parkin_asyn_dam_Ub2 + Parkin_asyn_dam_Ub2_DUB + Parkin_asyn_dam_Ub3 + Parkin_asyn_dam_Ub3_DUB + Parkin_asyn_dam_Ub4 + Parkin_asyn_dam_Ub4_DUB + Parkin_asyn_dam_Ub5 + Parkin_asyn_dam_Ub5_DUB + Parkin_asyn_dam_Ub6 + Parkin_asyn_dam_Ub6_DUB + Parkin_asyn_dam_Ub7 + Parkin_asyn_dam_Ub7_DUB + Parkin_asyn_dam_Ub8 + Parkin_asyn_dam_Ub8_DUB;
  Tot_asyn := asyn + asyn_Lamp2a + asyn_Proteasome;
  Tot_UCHL1 := UCHL1 + UCHL1_substrate;
  UCHL1_substrate := E3SUB_SUB_misfolded_Ub_UCHL1 + E3SUB_SUB_misfolded_Ub2_UCHL1 + E3SUB_SUB_misfolded_Ub3_UCHL1 + E3SUB_SUB_misfolded_Ub4_UCHL1 + E3SUB_SUB_misfolded_Ub5_UCHL1 + E3SUB_SUB_misfolded_Ub6_UCHL1 + E3SUB_SUB_misfolded_Ub7_UCHL1 + E3SUB_SUB_misfolded_Ub8_UCHL1 + Lamp2a_UCHL1_damaged + Ub_UCHL1 + UCHL1_damaged + UCHL1_damaged_Proteasome + UCHL1_Proteasome;

  // Reactions:
  UbSynthesis: $Source => Ub; kubs*Source;
  UbDegradation: Ub + Proteasome => Proteasome; kubd*Proteasome*Ub*kproteff;
  UbUpregulation: MisP => MisP + 3 Ub + 3 upregUb; kubss*(MisP^6/(1500^6 + MisP^6));
  ProteinSynthesis: $Source => NatP; ksynNatP*Source;
  Misfolding: NatP + ROS => MisP + ROS; kmisfold*NatP*ROS;
  Refolding: MisP => NatP; krefold*MisP;
  MisPE3Binding: MisP + E3 => E3_MisP; kbinMisPE3*MisP*E3;
  MisPE3Release: E3_MisP => MisP + E3; krelMisPE3*E3_MisP;
  E1UbBinding: E1 + Ub + $ATP => E1_Ub + $AMP; kbinE1Ub*E1*Ub*ATP/(5000 + ATP);
  E2UbBinding: E2 + E1_Ub => E2_Ub + E1; kbinE2Ub*E2*E1_Ub;
  Monoubiquitination: E2_Ub + E3_MisP => E3_MisP_Ub + E2; kmonoUb*E2_Ub*E3_MisP;
  Polyubiquitination1: E3_MisP_Ub + E2_Ub => E3_MisP_Ub2 + E2; kpolyUb*E3_MisP_Ub*E2_Ub;
  Polyubiquitination2: E3_MisP_Ub2 + E2_Ub => E3_MisP_Ub3 + E2; kpolyUb*E3_MisP_Ub2*E2_Ub;
  Polyubiquitination3: E3_MisP_Ub3 + E2_Ub => E3_MisP_Ub4 + E2; kpolyUb*E3_MisP_Ub3*E2_Ub;
  Polyubiquitination4: E3_MisP_Ub4 + E2_Ub => E3_MisP_Ub5 + E2; kpolyUb*E3_MisP_Ub4*E2_Ub;
  Polyubiquitination5: E3_MisP_Ub5 + E2_Ub => E3_MisP_Ub6 + E2; kpolyUb*E3_MisP_Ub5*E2_Ub;
  Polyubiquitination6: E3_MisP_Ub6 + E2_Ub => E3_MisP_Ub7 + E2; kpolyUb*E3_MisP_Ub6*E2_Ub;
  Polyubiquitination7: E3_MisP_Ub7 + E2_Ub => E3_MisP_Ub8 + E2; kpolyUb*E3_MisP_Ub7*E2_Ub;
  MisPDUBbinding1: E3_MisP_Ub + DUB => E3_MisP_Ub_DUB; kbinMisPDUB*E3_MisP_Ub*DUB;
  MisPDUBbinding2: E3_MisP_Ub2 + DUB => E3_MisP_Ub2_DUB; kbinMisPDUB*E3_MisP_Ub2*DUB;
  MisPDUBbinding3: E3_MisP_Ub3 + DUB => E3_MisP_Ub3_DUB; kbinMisPDUB*E3_MisP_Ub3*DUB;
  MisPDUBbinding4: E3_MisP_Ub4 + DUB => E3_MisP_Ub4_DUB; kbinMisPDUB*E3_MisP_Ub4*DUB;
  MisPDUBbinding5: E3_MisP_Ub5 + DUB => E3_MisP_Ub5_DUB; kbinMisPDUB*E3_MisP_Ub5*DUB;
  MisPDUBbinding6: E3_MisP_Ub6 + DUB => E3_MisP_Ub6_DUB; kbinMisPDUB*E3_MisP_Ub6*DUB;
  MisPDUBbinding7: E3_MisP_Ub7 + DUB => E3_MisP_Ub7_DUB; kbinMisPDUB*E3_MisP_Ub7*DUB;
  MisPDUBbinding8: E3_MisP_Ub8 + DUB => E3_MisP_Ub8_DUB; kbinMisPDUB*E3_MisP_Ub8*DUB;
  Deubiquitination8: E3_MisP_Ub8_DUB => E3_MisP_Ub7_DUB + Ub; kactDUB*E3_MisP_Ub8_DUB;
  Deubiquitination7: E3_MisP_Ub7_DUB => E3_MisP_Ub6_DUB + Ub; kactDUB*E3_MisP_Ub7_DUB;
  Deubiquitination6: E3_MisP_Ub6_DUB => E3_MisP_Ub5_DUB + Ub; kactDUB*E3_MisP_Ub6_DUB;
  Deubiquitination5: E3_MisP_Ub5_DUB => E3_MisP_Ub4_DUB + Ub; kactDUB*E3_MisP_Ub5_DUB;
  Deubiquitination4: E3_MisP_Ub4_DUB => E3_MisP_Ub3_DUB + Ub; kactDUB*E3_MisP_Ub4_DUB;
  Deubiquitination3: E3_MisP_Ub3_DUB => E3_MisP_Ub2_DUB + Ub; kactDUB*E3_MisP_Ub3_DUB;
  Deubiquitination2: E3_MisP_Ub2_DUB => E3_MisP_Ub_DUB + Ub; kactDUB*E3_MisP_Ub2_DUB;
  Deubiquitination1: E3_MisP_Ub_DUB => E3_MisP + DUB + Ub; kactDUB*E3_MisP_Ub_DUB;
  ProteasomeBindingUb4: E3_MisP_Ub4 + Proteasome => E3 + MisP_Ub4_Proteasome; kbinProt*E3_MisP_Ub4*Proteasome;
  ProteasomeBindingUb5: E3_MisP_Ub5 + Proteasome => E3 + MisP_Ub5_Proteasome; kbinProt*E3_MisP_Ub5*Proteasome;
  ProteasomeBindingUb6: E3_MisP_Ub6 + Proteasome => E3 + MisP_Ub6_Proteasome; kbinProt*E3_MisP_Ub6*Proteasome;
  ProteasomeBindingUb7: E3_MisP_Ub7 + Proteasome => E3 + MisP_Ub7_Proteasome; kbinProt*E3_MisP_Ub7*Proteasome;
  ProteasomeBindingUb8: E3_MisP_Ub8 + Proteasome => E3 + MisP_Ub8_Proteasome; kbinProt*E3_MisP_Ub8*Proteasome;
  DeubiquitinationBoundMisP5: MisP_Ub8_Proteasome + DUB => MisP_Ub7_Proteasome + Ub + DUB; kactDUBProt*MisP_Ub8_Proteasome*DUB;
  DeubiquitinationBoundMisP4: MisP_Ub7_Proteasome + DUB => MisP_Ub6_Proteasome + Ub + DUB; kactDUBProt*MisP_Ub7_Proteasome*DUB;
  DeubiquitinationBoundMisP3: MisP_Ub6_Proteasome + DUB => MisP_Ub5_Proteasome + Ub + DUB; kactDUBProt*MisP_Ub6_Proteasome*DUB;
  DeubiquitinationBoundMisP2: MisP_Ub5_Proteasome + DUB => MisP_Ub4_Proteasome + Ub + DUB; kactDUBProt*MisP_Ub5_Proteasome*DUB;
  DeubiquitinationBoundMisP1: MisP_Ub4_Proteasome + DUB => MisP + Proteasome + 4 Ub + DUB; kactDUBProt*MisP_Ub4_Proteasome*DUB;
  ProteasomeActivity1: MisP_Ub4_Proteasome + $ATP => 4 Ub + Proteasome + $ADP; kactProt*kproteff*MisP_Ub4_Proteasome*ATP/(5000 + ATP);
  ProteasomeActivity2: MisP_Ub5_Proteasome + $ATP => 5 Ub + Proteasome + $ADP; kactProt*kproteff*MisP_Ub5_Proteasome*ATP/(5000 + ATP);
  ProteasomeActivity3: MisP_Ub6_Proteasome + $ATP => 6 Ub + Proteasome + $ADP; kactProt*kproteff*MisP_Ub6_Proteasome*ATP/(5000 + ATP);
  ProteasomeActivity4: MisP_Ub7_Proteasome + $ATP => 7 Ub + Proteasome + $ADP; kactProt*kproteff*MisP_Ub7_Proteasome*ATP/(5000 + ATP);
  ProteasomeActivity5: MisP_Ub8_Proteasome + $ATP => 8 Ub + Proteasome + $ADP; kactProt*kproteff*MisP_Ub8_Proteasome*ATP/(5000 + ATP);
  Aggregation1: 2 MisP => AggP1; kagg1*MisP*(MisP - 1)*0.5;
  Aggregation2: MisP + AggP1 => AggP2; kagg2*MisP*AggP1;
  Aggregation3: MisP + AggP2 => AggP3; kagg2*MisP*AggP2;
  Aggregation4: MisP + AggP3 => AggP4; kagg2*MisP*AggP3;
  Aggregation5: MisP + AggP4 => AggP5; kagg2*MisP*AggP4;
  Disaggregation1: AggP5 => AggP4 + MisP; kdisagg5*AggP5;
  Disaggregation2: AggP4 => AggP3 + MisP; kdisagg4*AggP4;
  Disaggregation3: AggP3 => AggP2 + MisP; kdisagg3*AggP3;
  Disaggregation4: AggP2 => AggP1 + MisP; kdisagg2*AggP2;
  Disaggregation5: AggP1 => 2 MisP; kdisagg1*AggP1;
  InclusionFormation: MisP + AggP5 => SeqAggP + 7 aggMisP; kagg2*MisP*AggP5;
  InclusionGrowth1: MisP + SeqAggP => 2 SeqAggP + aggMisP; kigrowth1*MisP*SeqAggP;
  InclusionGrowth2: E3_MisP + SeqAggP => 2 SeqAggP + aggMisP + aggE3; kigrowth2*E3_MisP*SeqAggP;
  InclusionGrowth3: E3_MisP_Ub + SeqAggP => 2 SeqAggP + aggMisP + aggUb + aggE3; kigrowth2*E3_MisP_Ub*SeqAggP;
  InclusionGrowth4: E3_MisP_Ub2 + SeqAggP => 2 SeqAggP + aggMisP + 2 aggUb + aggE3; kigrowth2*E3_MisP_Ub2*SeqAggP;
  InclusionGrowth5: E3_MisP_Ub3 + SeqAggP => 2 SeqAggP + aggMisP + 3 aggUb + aggE3; kigrowth2*E3_MisP_Ub3*SeqAggP;
  InclusionGrowth6: E3_MisP_Ub4 + SeqAggP => 2 SeqAggP + aggMisP + 4 aggUb + aggE3; kigrowth2*E3_MisP_Ub4*SeqAggP;
  InclusionGrowth7: E3_MisP_Ub5 + SeqAggP => 2 SeqAggP + aggMisP + 5 aggUb + aggE3; kigrowth2*E3_MisP_Ub5*SeqAggP;
  InclusionGrowth8: E3_MisP_Ub6 + SeqAggP => 2 SeqAggP + aggMisP + 6 aggUb + aggE3; kigrowth2*E3_MisP_Ub6*SeqAggP;
  InclusionGrowth9: E3_MisP_Ub7 + SeqAggP => 2 SeqAggP + aggMisP + 7 aggUb + aggE3; kigrowth2*E3_MisP_Ub7*SeqAggP;
  InclusionGrowth10: E3_MisP_Ub8 + SeqAggP => 2 SeqAggP + 8 aggUb + aggE3; kigrowth2*E3_MisP_Ub8*SeqAggP;
  InclusionGrowth11: E3_MisP_Ub_DUB + SeqAggP => 2 SeqAggP + aggMisP + aggUb + aggE3 + aggDUB; kigrowth2*E3_MisP_Ub_DUB*SeqAggP;
  InclusionGrowth12: E3_MisP_Ub2_DUB + SeqAggP => 2 SeqAggP + aggMisP + 2 aggUb + aggE3 + aggDUB; kigrowth2*E3_MisP_Ub2_DUB*SeqAggP;
  InclusionGrowth13: E3_MisP_Ub3_DUB + SeqAggP => 2 SeqAggP + aggMisP + 3 aggUb + aggE3 + aggDUB; kigrowth2*E3_MisP_Ub3_DUB*SeqAggP;
  InclusionGrowth14: E3_MisP_Ub4_DUB + SeqAggP => 2 SeqAggP + aggMisP + 4 aggUb + aggE3 + aggDUB; kigrowth2*E3_MisP_Ub4_DUB*SeqAggP;
  InclusionGrowth15: E3_MisP_Ub5_DUB + SeqAggP => 2 SeqAggP + aggMisP + 5 aggUb + aggE3 + aggDUB; kigrowth2*E3_MisP_Ub5_DUB*SeqAggP;
  InclusionGrowth16: E3_MisP_Ub6_DUB + SeqAggP => 2 SeqAggP + aggMisP + 6 aggUb + aggE3 + aggDUB; kigrowth2*E3_MisP_Ub6_DUB*SeqAggP;
  InclusionGrowth17: E3_MisP_Ub7_DUB + SeqAggP => 2 SeqAggP + aggMisP + 7 aggUb + aggE3 + aggDUB; kigrowth2*E3_MisP_Ub7_DUB*SeqAggP;
  InclusionGrowth18: E3_MisP_Ub8_DUB + SeqAggP => 2 SeqAggP + aggMisP + 8 aggUb + aggE3 + aggDUB; kigrowth2*E3_MisP_Ub8_DUB*SeqAggP;
  ProteasomeInhibition1: AggP1 + Proteasome => AggP_Proteasome; kbinAggProt*AggP1*Proteasome;
  ProteasomeInhibition2: AggP2 + Proteasome => AggP_Proteasome; kbinAggProt*AggP2*Proteasome;
  ProteasomeInhibition3: AggP3 + Proteasome => AggP_Proteasome; kbinAggProt*AggP3*Proteasome;
  ProteasomeInhibition4: AggP4 + Proteasome => AggP_Proteasome; kbinAggProt*AggP4*Proteasome;
  ProteasomeInhibition5: AggP5 + Proteasome => AggP_Proteasome; kbinAggProt*AggP5*Proteasome;
  ROSgenerationSmallAggP1: AggP1 => AggP1 + ROS; kgenROSAggP*AggP1;
  ROSgenerationSmallAggP2: AggP2 => AggP2 + ROS; kgenROSAggP*AggP2;
  ROSgenerationSmallAggP3: AggP3 => AggP3 + ROS; kgenROSAggP*AggP3;
  ROSgenerationSmallAggP4: AggP4 => AggP4 + ROS; kgenROSAggP*AggP4;
  ROSgenerationSmallAggP5: AggP5 => AggP5 + ROS; kgenROSAggP*AggP5;
  UCHL1Synthesis: $Source => UCHL1; ksynUCHL1*Source;
  UCHL1ProteasomeBinding: UCHL1 + Proteasome => UCHL1_Proteasome; kbinUCHL1Prot*UCHL1*Proteasome;
  UCHL1ProteasomeDegradation: UCHL1_Proteasome => Proteasome; kdegProtUCHL1*UCHL1_Proteasome*kproteff;
  UCHL1LysosomalDegradation: UCHL1 + Lysosome => Lysosome; kdegLysUCHL1*UCHL1*Lysosome;
  UCHL1damage: UCHL1 + ROS => UCHL1_damaged + ROS; kdamUCHL1*UCHL1*ROS;
  UCHL1DamgedProteasomeBinding: UCHL1_damaged + Proteasome => UCHL1_damaged_Proteasome; kbinUCHL1Prot*UCHL1_damaged*Proteasome;
  UCHL1DamagedProteasomeDegradation: UCHL1_damaged_Proteasome => Proteasome; kdegProtUCHL1*UCHL1_damaged_Proteasome*kproteff;
  UCHL1DamagedLysosomalDegradation: UCHL1_damaged + Lysosome => Lysosome; kdegLysUCHL1dam*UCHL1_damaged*Lysosome;
  UCHL1Lamp2abinding: UCHL1_damaged + Lamp2a => Lamp2a_UCHL1_damaged; kbinLamp2aUCHL1dam*UCHL1_damaged*Lamp2a;
  UCHL1Lamp2aRelease: Lamp2a_UCHL1_damaged => UCHL1_damaged + Lamp2a; krelLamp2aUCHL1dam*Lamp2a_UCHL1_damaged;
  UbUCHL1binding: Ub + UCHL1 => Ub_UCHL1; kbinUbUCHL1*Ub*UCHL1;
  UbUCHL1release: Ub_UCHL1 => Ub + UCHL1; krelUbUCHL1*Ub_UCHL1;
  SUBsynthesis: $Source => SUB; ksynSUB*Source;
  SUBmisfolding: SUB + ROS => SUB_misfolded + ROS; kmisfoldSUB*SUB*ROS;
  SUBRefolding: SUB_misfolded => SUB; krefoldSUB*SUB_misfolded;
  E3SUBBinding: SUB_misfolded + E3SUB => E3SUB_SUB_misfolded; kbinE3SUB*SUB_misfolded*E3SUB;
  E3SUBRelease: E3SUB_SUB_misfolded => SUB_misfolded + E3SUB; krelE3SUB*E3SUB_SUB_misfolded;
  SUBMonoubiquitination: E2_Ub + E3SUB_SUB_misfolded => E3SUB_SUB_misfolded_Ub + E2; kmonoUb*E2_Ub*E3SUB_SUB_misfolded;
  SUBPolyubiquitination1: E3SUB_SUB_misfolded_Ub + E2_Ub => E3SUB_SUB_misfolded_Ub2 + E2; kpolyUb*E3SUB_SUB_misfolded_Ub*E2_Ub;
  SUBPolyubiquitination2: E3SUB_SUB_misfolded_Ub2 + E2_Ub => E3SUB_SUB_misfolded_Ub3 + E2; kpolyUb*E3SUB_SUB_misfolded_Ub2*E2_Ub;
  SUBPolyubiquitination3: E3SUB_SUB_misfolded_Ub3 + E2_Ub => E3SUB_SUB_misfolded_Ub4 + E2; kpolyUb*E3SUB_SUB_misfolded_Ub3*E2_Ub;
  SUBPolyubiquitination4: E3SUB_SUB_misfolded_Ub4 + E2_Ub => E3SUB_SUB_misfolded_Ub5 + E2; kpolyUb*E3SUB_SUB_misfolded_Ub4*E2_Ub;
  SUBPolyubiquitination5: E3SUB_SUB_misfolded_Ub5 + E2_Ub => E3SUB_SUB_misfolded_Ub6 + E2; kpolyUb*E3SUB_SUB_misfolded_Ub5*E2_Ub;
  SUBPolyubiquitination6: E3SUB_SUB_misfolded_Ub6 + E2_Ub => E3SUB_SUB_misfolded_Ub7 + E2; kpolyUb*E3SUB_SUB_misfolded_Ub6*E2_Ub;
  SUBPolyubiquitination7: E3SUB_SUB_misfolded_Ub7 + E2_Ub => E3SUB_SUB_misfolded_Ub8 + E2; kpolyUb*E3SUB_SUB_misfolded_Ub7*E2_Ub;
  SUBUCHL1binding1: E3SUB_SUB_misfolded_Ub + UCHL1 => E3SUB_SUB_misfolded_Ub_UCHL1; kbinSUBUCHL1*E3SUB_SUB_misfolded_Ub*UCHL1;
  SUBUCHL1binding2: E3SUB_SUB_misfolded_Ub2 + UCHL1 => E3SUB_SUB_misfolded_Ub2_UCHL1; kbinSUBUCHL1*E3SUB_SUB_misfolded_Ub2*UCHL1;
  SUBUCHL1binding3: E3SUB_SUB_misfolded_Ub3 + UCHL1 => E3SUB_SUB_misfolded_Ub3_UCHL1; kbinSUBUCHL1*E3SUB_SUB_misfolded_Ub3*UCHL1;
  SUBUCHL1binding4: E3SUB_SUB_misfolded_Ub4 + UCHL1 => E3SUB_SUB_misfolded_Ub4_UCHL1; kbinSUBUCHL1*E3SUB_SUB_misfolded_Ub4*UCHL1;
  SUBUCHL1binding5Ub_UCHL1: E3SUB_SUB_misfolded_Ub5 + UCHL1 => E3SUB_SUB_misfolded_Ub5_UCHL1; kbinSUBUCHL1*E3SUB_SUB_misfolded_Ub5*UCHL1;
  SUBUCHL1binding6: E3SUB_SUB_misfolded_Ub6 + UCHL1 => E3SUB_SUB_misfolded_Ub6_UCHL1; kbinSUBUCHL1*E3SUB_SUB_misfolded_Ub6*UCHL1;
  SUBUCHL1binding7: E3SUB_SUB_misfolded_Ub7 + UCHL1 => E3SUB_SUB_misfolded_Ub7_UCHL1; kbinSUBUCHL1*E3SUB_SUB_misfolded_Ub7*UCHL1;
  SUBUCHL1binding8: E3SUB_SUB_misfolded_Ub8 + UCHL1 => E3SUB_SUB_misfolded_Ub8_UCHL1; kbinSUBUCHL1*E3SUB_SUB_misfolded_Ub8*UCHL1;
  SUBDeubiquitination8: E3SUB_SUB_misfolded_Ub8_UCHL1 => E3SUB_SUB_misfolded_Ub7_UCHL1 + Ub; kactUchl1*E3SUB_SUB_misfolded_Ub8_UCHL1;
  SUBDeubiquitination7: E3SUB_SUB_misfolded_Ub7_UCHL1 => E3SUB_SUB_misfolded_Ub6_UCHL1 + Ub; kactUchl1*E3SUB_SUB_misfolded_Ub7_UCHL1;
  SUBDeubiquitination6: E3SUB_SUB_misfolded_Ub6_UCHL1 => E3SUB_SUB_misfolded_Ub5_UCHL1 + Ub; kactUchl1*E3SUB_SUB_misfolded_Ub6_UCHL1;
  SUBDeubiquitination5: E3SUB_SUB_misfolded_Ub5_UCHL1 => E3SUB_SUB_misfolded_Ub4_UCHL1 + Ub; kactUchl1*E3SUB_SUB_misfolded_Ub5_UCHL1;
  SUBDeubiquitination4: E3SUB_SUB_misfolded_Ub4_UCHL1 => E3SUB_SUB_misfolded_Ub3_UCHL1 + Ub; kactUchl1*E3SUB_SUB_misfolded_Ub4_UCHL1;
  SUBDeubiquitination3: E3SUB_SUB_misfolded_Ub3_UCHL1 => E3SUB_SUB_misfolded_Ub2_UCHL1 + Ub; kactUchl1*E3SUB_SUB_misfolded_Ub3_UCHL1;
  SUBDeubiquitination2: E3SUB_SUB_misfolded_Ub2_UCHL1 => E3SUB_SUB_misfolded_Ub_UCHL1 + Ub; kactUchl1*E3SUB_SUB_misfolded_Ub2_UCHL1;
  SUBDeubiquitination1: E3SUB_SUB_misfolded_Ub_UCHL1 => E3SUB_SUB_misfolded + UCHL1 + Ub; kactUchl1*E3SUB_SUB_misfolded_Ub_UCHL1;
  SUBProteasomeBindingUb4: E3SUB_SUB_misfolded_Ub4 + Proteasome => SUB_misfolded_Ub4_Proteasome + E3SUB; kbinProt*E3SUB_SUB_misfolded_Ub4*Proteasome;
  SUBProteasomeBindingUb5: E3SUB_SUB_misfolded_Ub5 + Proteasome => SUB_misfolded_Ub5_Proteasome + E3SUB; kbinProt*E3SUB_SUB_misfolded_Ub5*Proteasome;
  SUBProteasomeBindingUb6: E3SUB_SUB_misfolded_Ub6 + Proteasome => SUB_misfolded_Ub6_Proteasome + E3SUB; kbinProt*E3SUB_SUB_misfolded_Ub6*Proteasome;
  SUBProteasomeBindingUb7: E3SUB_SUB_misfolded_Ub7 + Proteasome => SUB_misfolded_Ub7_Proteasome + E3SUB; kbinProt*E3SUB_SUB_misfolded_Ub7*Proteasome;
  SUBProteasomeBindingUb8: E3SUB_SUB_misfolded_Ub8 + Proteasome => SUB_misfolded_Ub8_Proteasome + E3SUB; kbinProt*E3SUB_SUB_misfolded_Ub8*Proteasome;
  DeubiquitinationBoundSUB8: SUB_misfolded_Ub8_Proteasome + DUB => SUB_misfolded_Ub7_Proteasome + Ub + DUB; kactDUBProt*SUB_misfolded_Ub8_Proteasome*DUB;
  DeubiquitinationBoundSUB7: SUB_misfolded_Ub7_Proteasome + DUB => SUB_misfolded_Ub6_Proteasome + Ub + DUB; kactDUBProt*SUB_misfolded_Ub7_Proteasome*DUB;
  DeubiquitinationBoundSUB6: SUB_misfolded_Ub6_Proteasome + DUB => SUB_misfolded_Ub5_Proteasome + Ub + DUB; kactDUBProt*SUB_misfolded_Ub6_Proteasome*DUB;
  DeubiquitinationBoundSUB5: SUB_misfolded_Ub5_Proteasome + DUB => SUB_misfolded_Ub4_Proteasome + Ub + DUB; kactDUBProt*SUB_misfolded_Ub5_Proteasome*DUB;
  DeubiquitinationBoundSUB4: SUB_misfolded_Ub4_Proteasome + DUB => SUB_misfolded + Proteasome + 4 Ub + DUB; kactDUBProt*SUB_misfolded_Ub4_Proteasome*DUB;
  SUBDegradationUb4: SUB_misfolded_Ub4_Proteasome + $ATP => 4 Ub + Proteasome + $ADP; kactProt*SUB_misfolded_Ub4_Proteasome*kproteff*ATP/(5000 + ATP);
  SUBDegradationUb5: SUB_misfolded_Ub5_Proteasome + $ATP => 5 Ub + Proteasome + $ADP; kactProt*SUB_misfolded_Ub5_Proteasome*kproteff*ATP/(5000 + ATP);
  SUBDegradationUb6: SUB_misfolded_Ub6_Proteasome + $ATP => 6 Ub + Proteasome + $ADP; kactProt*SUB_misfolded_Ub6_Proteasome*kproteff*ATP/(5000 + ATP);
  SUBDegradationUb7: SUB_misfolded_Ub7_Proteasome + $ATP => 7 Ub + Proteasome + $ADP; kactProt*SUB_misfolded_Ub7_Proteasome*kproteff*ATP/(5000 + ATP);
  SUBDegradationUb8: SUB_misfolded_Ub8_Proteasome + $ATP => 8 Ub + Proteasome + $ADP; kactProt*SUB_misfolded_Ub8_Proteasome*kproteff*ATP/(5000 + ATP);
  asynSynthesis1: $Source => asyn; ksynasyn*Source;
  asynProt20Sbinding: asyn + Proteasome => asyn_Proteasome; kbinasynProt*asyn*Proteasome;
  asynProt20Sdegradation: asyn_Proteasome => Proteasome; kdegasynProt*kproteff*asyn_Proteasome;
  asynLamp2aBinding: asyn + Lamp2a => asyn_Lamp2a; kbinasynLamp2a*asyn*Lamp2a;
  asynCMAdegradation: asyn_Lamp2a => Lamp2a; kCMAasyn*asyn_Lamp2a;
  asynDamage: asyn + ROS => asyn_dam + ROS; kdamasyn*ROS*asyn;
  asyn_damParkinBinding: asyn_dam + Parkin => Parkin_asyn_dam; kbinasynParkin*asyn_dam*Parkin;
  asyn_damParkinRelease: Parkin_asyn_dam => asyn_dam + Parkin; krelasynParkin*Parkin_asyn_dam;
  AsynMonoubiquitination: E2_Ub + Parkin_asyn_dam => Parkin_asyn_dam_Ub + E2; kmonoUb*E2_Ub*Parkin_asyn_dam;
  AsynPolyubiquitination1: Parkin_asyn_dam_Ub + E2_Ub => Parkin_asyn_dam_Ub2 + E2; kpolyUb*Parkin_asyn_dam_Ub*E2_Ub;
  AsynPolyubiquitination2: Parkin_asyn_dam_Ub2 + E2_Ub => Parkin_asyn_dam_Ub3 + E2; kpolyUb*Parkin_asyn_dam_Ub2*E2_Ub;
  AsynPolyubiquitination3: Parkin_asyn_dam_Ub3 + E2_Ub => Parkin_asyn_dam_Ub4 + E2; kpolyUb*Parkin_asyn_dam_Ub3*E2_Ub;
  AsynPolyubiquitination4: Parkin_asyn_dam_Ub4 + E2_Ub => Parkin_asyn_dam_Ub5 + E2; kpolyUb*Parkin_asyn_dam_Ub4*E2_Ub;
  AsynPolyubiquitination5: Parkin_asyn_dam_Ub5 + E2_Ub => Parkin_asyn_dam_Ub6 + E2; kpolyUb*Parkin_asyn_dam_Ub5*E2_Ub;
  AsynPolyubiquitination6: Parkin_asyn_dam_Ub6 + E2_Ub => Parkin_asyn_dam_Ub7 + E2; kpolyUb*Parkin_asyn_dam_Ub6*E2_Ub;
  AsynPolyubiquitination7: Parkin_asyn_dam_Ub7 + E2_Ub => Parkin_asyn_dam_Ub8 + E2; kpolyUb*Parkin_asyn_dam_Ub7*E2_Ub;
  AsynDUBbindingUb8: Parkin_asyn_dam_Ub8 + DUB => Parkin_asyn_dam_Ub8_DUB; kbinasynDUB*Parkin_asyn_dam_Ub8*DUB;
  AsynDUBbindingUb7: Parkin_asyn_dam_Ub7 + DUB => Parkin_asyn_dam_Ub7_DUB; kbinasynDUB*Parkin_asyn_dam_Ub7*DUB;
  AsynDUBbindingUb6: Parkin_asyn_dam_Ub6 + DUB => Parkin_asyn_dam_Ub6_DUB; kbinasynDUB*Parkin_asyn_dam_Ub6*DUB;
  AsynDUBbindingUb5: Parkin_asyn_dam_Ub5 + DUB => Parkin_asyn_dam_Ub5_DUB; kbinasynDUB*Parkin_asyn_dam_Ub5*DUB;
  AsynDUBbindingUb4: Parkin_asyn_dam_Ub4 + DUB => Parkin_asyn_dam_Ub4_DUB; kbinasynDUB*Parkin_asyn_dam_Ub4*DUB;
  AsynDUBbindingUb3: Parkin_asyn_dam_Ub3 + DUB => Parkin_asyn_dam_Ub3_DUB; kbinasynDUB*Parkin_asyn_dam_Ub3*DUB;
  AsynDUBbindingUb2: Parkin_asyn_dam_Ub2 + DUB => Parkin_asyn_dam_Ub2_DUB; kbinasynDUB*Parkin_asyn_dam_Ub2*DUB;
  AsynDUBbindingUb1: Parkin_asyn_dam_Ub + DUB => Parkin_asyn_dam_Ub_DUB; kbinasynDUB*Parkin_asyn_dam_Ub*DUB;
  AsynDeubiquitinationUb8: Parkin_asyn_dam_Ub8_DUB => Parkin_asyn_dam_Ub7_DUB + Ub; kactDUB*Parkin_asyn_dam_Ub8_DUB;
  AsynDeubiquitinationUb7: Parkin_asyn_dam_Ub7_DUB => Parkin_asyn_dam_Ub6_DUB + Ub; kactDUB*Parkin_asyn_dam_Ub7_DUB;
  AsynDeubiquitinationUb6: Parkin_asyn_dam_Ub6_DUB => Parkin_asyn_dam_Ub5_DUB + Ub; kactDUB*Parkin_asyn_dam_Ub6_DUB;
  AsynDeubiquitinationUb5: Parkin_asyn_dam_Ub5_DUB => Parkin_asyn_dam_Ub4_DUB + Ub; kactDUB*Parkin_asyn_dam_Ub5_DUB;
  AsynDeubiquitinationUb4: Parkin_asyn_dam_Ub4_DUB => Parkin_asyn_dam_Ub3_DUB + Ub; kactDUB*Parkin_asyn_dam_Ub4_DUB;
  AsynDeubiquitinationUb3: Parkin_asyn_dam_Ub3_DUB => Parkin_asyn_dam_Ub2_DUB + Ub; kactDUB*Parkin_asyn_dam_Ub3_DUB;
  AsynDeubiquitinationUb2: Parkin_asyn_dam_Ub2_DUB => Parkin_asyn_dam_Ub_DUB + Ub; kactDUB*Parkin_asyn_dam_Ub2_DUB;
  AsynDeubiquitinationUb1: Parkin_asyn_dam_Ub_DUB => Parkin_asyn_dam + DUB + Ub; kactDUB*Parkin_asyn_dam_Ub_DUB;
  AsynProteasomeBindingUb4: Parkin_asyn_dam_Ub4 + Proteasome => asyn_dam_Ub4_Proteasome + Parkin; kbinProt*Parkin_asyn_dam_Ub4*Proteasome;
  AsynProteasomeBindingUb5: Parkin_asyn_dam_Ub5 + Proteasome => asyn_dam_Ub5_Proteasome + Parkin; kbinProt*Parkin_asyn_dam_Ub5*Proteasome;
  AsynProteasomeBindingUb6: Parkin_asyn_dam_Ub6 + Proteasome => asyn_dam_Ub6_Proteasome + Parkin; kbinProt*Parkin_asyn_dam_Ub6*Proteasome;
  AsynProteasomeBindingUb7: Parkin_asyn_dam_Ub7 + Proteasome => asyn_dam_Ub7_Proteasome + Parkin; kbinProt*Parkin_asyn_dam_Ub7*Proteasome;
  AsynProteasomeBindingUb8: Parkin_asyn_dam_Ub8 + Proteasome => asyn_dam_Ub8_Proteasome + Parkin; kbinProt*Parkin_asyn_dam_Ub8*Proteasome;
  DeubiquitinationBoundasyn_damUb8: asyn_dam_Ub8_Proteasome + DUB => asyn_dam_Ub7_Proteasome + Ub + DUB; kactDUBProt*asyn_dam_Ub8_Proteasome*DUB;
  DeubiquitinationBoundasynDamUb7: asyn_dam_Ub7_Proteasome + DUB => asyn_dam_Ub6_Proteasome + Ub + DUB; kactDUBProt*asyn_dam_Ub7_Proteasome*DUB;
  DeubiquitinationBoundasynDamUb6: asyn_dam_Ub6_Proteasome + DUB => asyn_dam_Ub5_Proteasome + Ub + DUB; kactDUBProt*asyn_dam_Ub6_Proteasome*DUB;
  DeubiquitinationBoundasynDamUb5: asyn_dam_Ub5_Proteasome + DUB => asyn_dam_Ub4_Proteasome + Ub + DUB; kactDUBProt*asyn_dam_Ub5_Proteasome*DUB;
  DeubiquitinationBoundasynDamUb4: asyn_dam_Ub4_Proteasome + DUB => asyn_dam + Proteasome + 4 Ub + DUB; kactDUBProt*asyn_dam_Ub4_Proteasome*DUB;
  AsynProteasomeActivityUb4: asyn_dam_Ub4_Proteasome + $ATP => 4 Ub + Proteasome + $ADP; kactProt*kproteff*asyn_dam_Ub4_Proteasome*ATP/(5000 + ATP);
  AsynDegradationUb5: asyn_dam_Ub5_Proteasome + $ATP => 5 Ub + Proteasome + $ADP; kactProt*kproteff*asyn_dam_Ub5_Proteasome*ATP/(5000 + ATP);
  AsynDegradationUb6: asyn_dam_Ub6_Proteasome + $ATP => 6 Ub + Proteasome + $ADP; kactProt*kproteff*asyn_dam_Ub6_Proteasome*ATP/(5000 + ATP);
  AsynDegradationUb7: asyn_dam_Ub7_Proteasome + $ATP => 7 Ub + Proteasome + $ADP; kactProt*kproteff*asyn_dam_Ub7_Proteasome*ATP/(5000 + ATP);
  AsynDegradationUb8: asyn_dam_Ub8_Proteasome + $ATP => 8 Ub + Proteasome + $ADP; kactProt*kproteff*asyn_dam_Ub8_Proteasome*ATP/(5000 + ATP);
  Aggregationasyn1: 2 asyn => AggA1; kaggasyn1*asyn*(asyn - 1)*0.5;
  Aggregationasyn2: asyn + AggA1 => AggA2; kaggasyn2*asyn*AggA1;
  Aggregationasyn3: asyn + AggA2 => AggA3; kaggasyn2*asyn*AggA2;
  Aggregationasyn4: asyn + AggA3 => AggA4; kaggasyn2*asyn*AggA3;
  Aggregationasyn5: asyn + AggA4 => AggA5; kaggasyn2*asyn*AggA4;
  DisAggregationasyn1: AggA5 => AggA4 + asyn; kdisaggasyn5*AggA5;
  DisAggregationasyn2: AggA4 => AggA3 + asyn; kdisaggasyn4*AggA4;
  DisAggregationasyn3: AggA3 => AggA2 + asyn; kdisaggasyn3*AggA3;
  DisAggregationasyn4: AggA2 => AggA1 + asyn; kdisaggasyn2*AggA2;
  DisAggregationasyn5: AggA1 => 2 asyn; kdisaggasyn1*AggA1;
  AggA1ProteasomeInhibition: AggA1 + Proteasome => AggP_Proteasome; kbinAggProt*AggA1*Proteasome;
  AggA2ProteasomeInhibition: AggA2 + Proteasome => AggP_Proteasome; kbinAggProt*AggA2*Proteasome;
  AggA3ProteasomeInhibition: AggA3 + Proteasome => AggP_Proteasome; kbinAggProt*AggA3*Proteasome;
  AggA4ProteasomeInhibition: AggA4 + Proteasome => AggP_Proteasome; kbinAggProt*AggA4*Proteasome;
  AggA5ProteasomeInhibition: AggA5 + Proteasome => AggP_Proteasome; kbinAggProt*AggA5*Proteasome;
  AsynInclusionFormation: asyn + AggA5 => SeqAggP + 7 aggasyn; kaggasyn2*asyn*AggA5;
  AsynInclusionGrowth: SeqAggP + asyn => 2 SeqAggP + aggasyn; kigrowth1*SeqAggP*asyn;
  ROSgenerationSmallAggA1: AggA1 => AggA1 + ROS; kgenROSAggP*AggA1;
  ROSgenerationSmallAggA2: AggA2 => AggA2 + ROS; kgenROSAggP*AggA2;
  ROSgenerationSmallAggA3: AggA3 => AggA3 + ROS; kgenROSAggP*AggA3;
  ROSgenerationSmallAggA4: AggA4 => AggA4 + ROS; kgenROSAggP*AggA4;
  ROSgenerationSmallAggA5: AggA5 => AggA5 + ROS; kgenROSAggP*AggA5;
  AggregationAsynDam1: 2 asyn_dam => AggD1; kagg1dam*asyn_dam*(asyn_dam - 1)*0.5;
  AggregationAsynDam2: asyn_dam + AggD1 => AggD2; kagg2dam*asyn_dam*AggD1;
  AggregationAsynDam3: asyn_dam + AggD2 => AggD3; kagg2dam*asyn_dam*AggD2;
  AggregationAsynDam4: asyn_dam + AggD3 => AggD4; kagg2dam*asyn_dam*AggD3;
  AggregationAsynDam5: asyn_dam + AggD4 => AggD5; kagg2dam*asyn_dam*AggD4;
  DisaggregationAsynDam1: AggD5 => AggD4 + asyn_dam; kdisaggasyndam5*AggD5;
  DisaggregationAsynDam2: AggD4 => AggD3 + asyn_dam; kdisaggasyndam4*AggD4;
  DisaggregationAsynDam3: AggD3 => AggD2 + asyn_dam; kdisaggasyndam3*AggD3;
  DisaggregationAsynDam4: AggD2 => AggD1 + asyn_dam; kdisaggasyndam2*AggD2;
  DisaggregationAsynDam5: AggD1 => 2 asyn_dam; kdisaggasyndam1*AggD1;
  AggD1ProteasomeInhibition: AggD1 + Proteasome => AggP_Proteasome; kbinAggProt*AggD1*Proteasome;
  AggD2ProteasomeInhibition: AggD2 + Proteasome => AggP_Proteasome; kbinAggProt*AggD2*Proteasome;
  AggD3ProteasomeInhibition: AggD3 + Proteasome => AggP_Proteasome; kbinAggProt*AggD3*Proteasome;
  AggD4ProteasomeInhibition: AggD4 + Proteasome => AggP_Proteasome; kbinAggProt*AggD4*Proteasome;
  AggD5ProteasomeInhibition: AggD5 + Proteasome => AggP_Proteasome; kbinAggProt*AggD5*Proteasome;
  AsynDamInclusionFormation: asyn_dam + AggD5 => SeqAggP + 7 aggasyndam; kagg2dam*asyn_dam*AggD5;
  AsynDamInclusionGrowth1: SeqAggP + asyn_dam => 2 SeqAggP + aggasyndam; kigrowth1*SeqAggP*asyn_dam;
  AsynDamInclusionGrowth2: SeqAggP + Parkin_asyn_dam => 2 SeqAggP + aggasyndam + aggParkin; kigrowth2*SeqAggP*Parkin_asyn_dam;
  AsynDamInclusionGrowth3: SeqAggP + Parkin_asyn_dam_Ub => 2 SeqAggP + aggasyndam + aggUb + aggParkin; kigrowth2*SeqAggP*Parkin_asyn_dam_Ub;
  AsynDamInclusionGrowth4: SeqAggP + Parkin_asyn_dam_Ub2 => 2 SeqAggP + aggasyndam + 2 aggUb + aggParkin; kigrowth2*SeqAggP*Parkin_asyn_dam_Ub2;
  AsynDamInclusionGrowth5: SeqAggP + Parkin_asyn_dam_Ub3 => 2 SeqAggP + aggasyndam + 3 aggUb + aggParkin; kigrowth2*SeqAggP*Parkin_asyn_dam_Ub3;
  AsynDamInclusionGrowth6: SeqAggP + Parkin_asyn_dam_Ub4 => 2 SeqAggP + aggasyndam + 4 aggUb + aggParkin; kigrowth2*SeqAggP*Parkin_asyn_dam_Ub4;
  AsynDamInclusionGrowth7: SeqAggP + Parkin_asyn_dam_Ub5 => 2 SeqAggP + aggasyndam + 5 aggUb + aggParkin; kigrowth2*SeqAggP*Parkin_asyn_dam_Ub5;
  AsynDamInclusionGrowth8: SeqAggP + Parkin_asyn_dam_Ub6 => 2 SeqAggP + aggasyndam + 6 aggUb + aggParkin; kigrowth2*SeqAggP*Parkin_asyn_dam_Ub6;
  AsynDamInclusionGrowth9: SeqAggP + Parkin_asyn_dam_Ub7 => 2 SeqAggP + aggasyndam + 7 aggUb + aggParkin; kigrowth2*SeqAggP*Parkin_asyn_dam_Ub7;
  AsynDamInclusionGrowth10: SeqAggP + Parkin_asyn_dam_Ub8 => 2 SeqAggP + aggasyndam + 8 aggUb + aggParkin; kigrowth2*SeqAggP*Parkin_asyn_dam_Ub8;
  AsynDamInclusionGrowth11: SeqAggP + Parkin_asyn_dam_Ub_DUB => 2 SeqAggP + aggasyndam + aggUb + aggParkin; kigrowth2*SeqAggP*Parkin_asyn_dam_Ub_DUB;
  AsynDamInclusionGrowth12: SeqAggP + Parkin_asyn_dam_Ub2_DUB => 2 SeqAggP + aggasyndam + 2 aggUb + aggParkin; kigrowth2*SeqAggP*Parkin_asyn_dam_Ub2_DUB;
  AsynDamInclusionGrowth13: SeqAggP + Parkin_asyn_dam_Ub3_DUB => 2 SeqAggP + aggasyndam + 3 aggUb + aggParkin; kigrowth2*SeqAggP*Parkin_asyn_dam_Ub3_DUB;
  AsynDamInclusionGrowth14: SeqAggP + Parkin_asyn_dam_Ub4_DUB => 2 SeqAggP + aggasyndam + 4 aggUb + aggParkin; kigrowth2*SeqAggP*Parkin_asyn_dam_Ub4_DUB;
  AsynDamInclusionGrowth15: SeqAggP + Parkin_asyn_dam_Ub5_DUB => 2 SeqAggP + aggasyndam + 5 aggUb + aggParkin; kigrowth2*SeqAggP*Parkin_asyn_dam_Ub5_DUB;
  AsynDamInclusionGrowth16: SeqAggP + Parkin_asyn_dam_Ub6_DUB => 2 SeqAggP + aggasyndam + 6 aggUb + aggParkin; kigrowth2*SeqAggP*Parkin_asyn_dam_Ub6_DUB;
  AsynDamInclusionGrowth17: SeqAggP + Parkin_asyn_dam_Ub7_DUB => 2 SeqAggP + aggasyndam + 7 aggUb + aggParkin; kigrowth2*SeqAggP*Parkin_asyn_dam_Ub7_DUB;
  AsynDamInclusionGrowth18: SeqAggP + Parkin_asyn_dam_Ub8_DUB => 2 SeqAggP + aggasyndam + 8 aggUb + aggParkin; kigrowth2*SeqAggP*Parkin_asyn_dam_Ub8_DUB;
  ROSgenerationSmallAggD1: AggD1 => AggD1 + ROS; kgenROSAggP*AggD1;
  ROSgenerationSmallAggD2: AggD2 => AggD2 + ROS; kgenROSAggP*AggD2;
  ROSgenerationSmallAggD3: AggD3 => AggD3 + ROS; kgenROSAggP*AggD3;
  ROSgenerationSmallAggD4: AggD4 => AggD4 + ROS; kgenROSAggP*AggD4;
  ROSgenerationSmallAggD5: AggD5 => AggD5 + ROS; kgenROSAggP*AggD5;
  AggregationUCHL1Dam1: 2 UCHL1_damaged => AggU1; kagg1dam*UCHL1_damaged*(UCHL1_damaged - 1)*0.5;
  AggregationUCHL1Dam2: UCHL1_damaged + AggU1 => AggU2; kagg2dam*UCHL1_damaged*AggU1;
  AggregationUCHL1Dam3: UCHL1_damaged + AggU2 => AggU3; kagg2dam*UCHL1_damaged*AggU2;
  AggregationUCHL1Dam4: UCHL1_damaged + AggU3 => AggU4; kagg2dam*UCHL1_damaged*AggU3;
  AggregationUCHL1Dam5: UCHL1_damaged + AggU4 => AggU5; kagg2dam*UCHL1_damaged*AggU4;
  DisaggregationUCHL1Dam1: AggU5 => AggU4 + UCHL1_damaged; kdisagguchl1dam5*AggU5;
  DisaggregationUCHL1Dam2: AggU4 => AggU3 + UCHL1_damaged; kdisagguchl1dam4*AggU4;
  DisaggregationUCHL1Dam3: AggU3 => AggU2 + UCHL1_damaged; kdisagguchl1dam3*AggU3;
  DisaggregationUCHL1Dam4: AggU2 => AggU1 + UCHL1_damaged; kdisagguchl1dam2*AggU2;
  DisaggregationUCHL1Dam5: AggU1 => 2 UCHL1_damaged; kdisagguchl1dam1*AggU1;
  AggU1ProteasomeInhibition: AggU1 + Proteasome => AggP_Proteasome; kbinAggProt*AggU1*Proteasome;
  AggU2ProteasomeInhibition: AggU2 + Proteasome => AggP_Proteasome; kbinAggProt*AggU2*Proteasome;
  AggU3ProteasomeInhibition: AggU3 + Proteasome => AggP_Proteasome; kbinAggProt*AggU3*Proteasome;
  AggU4ProteasomeInhibition: AggU4 + Proteasome => AggP_Proteasome; kbinAggProt*AggU4*Proteasome;
  AggU5ProteasomeInhibition: AggU5 + Proteasome => AggP_Proteasome; kbinAggProt*AggU5*Proteasome;
  UCHL1DamInclusionFormation: UCHL1_damaged + AggU5 => SeqAggP + 7 aggUchl1dam; kagg2dam*UCHL1_damaged*AggU5;
  UCHL1DamagedSequestering: SeqAggP + UCHL1_damaged => 2 SeqAggP + aggUchl1dam; kigrowth1*SeqAggP*UCHL1_damaged;
  UCHL1DamagedLamp2aSequestering: SeqAggP + Lamp2a_UCHL1_damaged => 2 SeqAggP + aggUchl1dam; kigrowth1*SeqAggP*Lamp2a_UCHL1_damaged;
  ROSgenerationSmallAggU1: AggU1 => AggU1 + ROS; kgenROSAggP*AggU1;
  ROSgenerationSmallAggU2: AggU2 => AggU2 + ROS; kgenROSAggP*AggU2;
  ROSgenerationSmallAggU3: AggU3 => AggU3 + ROS; kgenROSAggP*AggU3;
  ROSgenerationSmallAggU4: AggU4 => AggU4 + ROS; kgenROSAggP*AggU4;
  ROSgenerationSmallAggU5: AggU5 => AggU5 + ROS; kgenROSAggP*AggU5;
  SUBAggregation1: 2 SUB_misfolded => AggS1; kaggSUB1*SUB_misfolded*(SUB_misfolded - 1)*0.5;
  SUBAggregation2: SUB_misfolded + AggS1 => AggS2; kaggSUB2*SUB_misfolded*AggS1;
  SUBAggregation3: SUB_misfolded + AggS2 => AggS3; kaggSUB2*SUB_misfolded*AggS2;
  SUBAggregation4: SUB_misfolded + AggS3 => AggS4; kaggSUB2*SUB_misfolded*AggS3;
  SUBAggregation5: SUB_misfolded + AggS4 => AggS5; kaggSUB2*SUB_misfolded*AggS4;
  SUBDisaggregation1: AggS5 => AggS4 + SUB_misfolded; kdisaggSUB5*AggS5;
  SUBDisaggregation2: AggS4 => AggS3 + SUB_misfolded; kdisaggSUB4*AggS4;
  SUBDisaggregation3: AggS3 => AggS2 + SUB_misfolded; kdisaggSUB3*AggS3;
  SUBDisaggregation4: AggS2 => AggS1 + SUB_misfolded; kdisaggSUB2*AggS2;
  SUBDisaggregation5: AggS1 => 2 SUB_misfolded; kdisaggSUB1*AggS1;
  AggS1ProteasomeInhibition: AggS1 + Proteasome => AggP_Proteasome; kbinAggProt*AggS1*Proteasome;
  AggS2ProteasomeInhibition: AggS2 + Proteasome => AggP_Proteasome; kbinAggProt*AggS2*Proteasome;
  AggS3ProteasomeInhibition: AggS3 + Proteasome => AggP_Proteasome; kbinAggProt*AggS3*Proteasome;
  AggS4ProteasomeInhibition: AggS4 + Proteasome => AggP_Proteasome; kbinAggProt*AggS4*Proteasome;
  AggS5ProteasomeInhibition: AggS5 + Proteasome => AggP_Proteasome; kbinAggProt*AggS5*Proteasome;
  SUBInclusionFormation: AggS5 + SUB_misfolded => SeqAggP + 7 aggSUB; kaggSUB2*AggS5*SUB_misfolded;
  SUBInclusionGrowth0: SeqAggP + SUB_misfolded => 2 SeqAggP + aggSUB; kigrowth1*SeqAggP*SUB_misfolded;
  SUBInclusionGrowth1: E3SUB_SUB_misfolded + SeqAggP => 2 SeqAggP + aggSUB; kigrowth2*E3SUB_SUB_misfolded*SeqAggP;
  SUBInclusionGrowth2: E3SUB_SUB_misfolded_Ub + SeqAggP => 2 SeqAggP + aggSUB + aggUb; kigrowth2*E3SUB_SUB_misfolded_Ub*SeqAggP;
  SUBInclusionGrowth3: E3SUB_SUB_misfolded_Ub2 + SeqAggP => 2 SeqAggP + aggSUB + 2 aggUb; kigrowth2*E3SUB_SUB_misfolded_Ub2*SeqAggP;
  SUBInclusionGrowth4: E3SUB_SUB_misfolded_Ub3 + SeqAggP => 2 SeqAggP + aggSUB + 3 aggUb; kigrowth2*E3SUB_SUB_misfolded_Ub3*SeqAggP;
  SUBInclusionGrowth5: E3SUB_SUB_misfolded_Ub4 + SeqAggP => 2 SeqAggP + aggSUB + 4 aggUb; kigrowth2*E3SUB_SUB_misfolded_Ub4*SeqAggP;
  SUBInclusionGrowth6: E3SUB_SUB_misfolded_Ub5 + SeqAggP => 2 SeqAggP + aggSUB + 5 aggUb; kigrowth2*E3SUB_SUB_misfolded_Ub5*SeqAggP;
  SUBInclusionGrowth7: E3SUB_SUB_misfolded_Ub6 + SeqAggP => 2 SeqAggP + aggSUB + 6 aggUb; kigrowth2*E3SUB_SUB_misfolded_Ub6*SeqAggP;
  SUBInclusionGrowth8: E3SUB_SUB_misfolded_Ub7 + SeqAggP => 2 SeqAggP + aggSUB + 7 aggUb; kigrowth2*E3SUB_SUB_misfolded_Ub7*SeqAggP;
  SUBInclusionGrowth9: E3SUB_SUB_misfolded_Ub8 + SeqAggP => 2 SeqAggP + aggSUB + 8 aggUb; kigrowth2*E3SUB_SUB_misfolded_Ub8*SeqAggP;
  SUBInclusionGrowth10: E3SUB_SUB_misfolded_Ub_UCHL1 + SeqAggP => 2 SeqAggP + aggSUB + aggUchl1 + aggUb; kigrowth2*E3SUB_SUB_misfolded_Ub_UCHL1*SeqAggP;
  SUBInclusionGrowth11: E3SUB_SUB_misfolded_Ub2_UCHL1 + SeqAggP => 2 SeqAggP + aggSUB + aggUchl1 + 2 aggUb; kigrowth2*E3SUB_SUB_misfolded_Ub2_UCHL1*SeqAggP;
  SUBInclusionGrowth12: E3SUB_SUB_misfolded_Ub3_UCHL1 + SeqAggP => 2 SeqAggP + aggSUB + aggUchl1 + 3 aggUb; kigrowth2*E3SUB_SUB_misfolded_Ub3_UCHL1*SeqAggP;
  SUBInclusionGrowth13: E3SUB_SUB_misfolded_Ub4_UCHL1 + SeqAggP => 2 SeqAggP + aggSUB + aggUchl1 + 4 aggUb; kigrowth2*E3SUB_SUB_misfolded_Ub4_UCHL1*SeqAggP;
  SUBInclusionGrowth14: E3SUB_SUB_misfolded_Ub5_UCHL1 + SeqAggP => 2 SeqAggP + aggSUB + aggUchl1 + 5 aggUb; kigrowth2*E3SUB_SUB_misfolded_Ub5_UCHL1*SeqAggP;
  SUBInclusionGrowth15: E3SUB_SUB_misfolded_Ub6_UCHL1 + SeqAggP => 2 SeqAggP + aggSUB + aggUchl1 + 6 aggUb; kigrowth2*E3SUB_SUB_misfolded_Ub6_UCHL1*SeqAggP;
  SUBInclusionGrowth16: E3SUB_SUB_misfolded_Ub7_UCHL1 + SeqAggP => 2 SeqAggP + aggSUB + aggUchl1 + 7 aggUb; kigrowth2*E3SUB_SUB_misfolded_Ub7_UCHL1*SeqAggP;
  SUBInclusionGrowth17: E3SUB_SUB_misfolded_Ub8_UCHL1 + SeqAggP => 2 SeqAggP + aggSUB + aggUchl1 + 8 aggUb; kigrowth2*E3SUB_SUB_misfolded_Ub8_UCHL1*SeqAggP;
  ROSgenerationSmallAggS1: AggS1 => AggS1 + ROS; kgenROSAggP*AggS1;
  ROSgenerationSmallAggS2: AggS2 => AggS2 + ROS; kgenROSAggP*AggS2;
  ROSgenerationSmallAggS3: AggS3 => AggS3 + ROS; kgenROSAggP*AggS3;
  ROSgenerationSmallAggS4: AggS4 => AggS4 + ROS; kgenROSAggP*AggS4;
  ROSgenerationSmallAggS5: AggS5 => AggS5 + ROS; kgenROSAggP*AggS5;
  radicalFormation: $Source => ROS; kgenROS*Source;
  radicalScavenging: ROS => $Sink; kremROS*ROS;

  // Species initializations:
  NatP = 6000/cytosol;
  MisP = 80/cytosol;
  Ub = 1500/cytosol;
  E1 = 105/cytosol;
  E2 = 50/cytosol;
  E3 = 300/cytosol;
  E3_MisP = 2/cytosol;
  DUB = 160/cytosol;
  Proteasome = 1500/cytosol;
  ROS = 10/cytosol;
  E1_Ub = 795/cytosol;
  E2_Ub = 950/cytosol;
  E3_MisP_Ub = 0;
  E3_MisP_Ub2 = 0;
  E3_MisP_Ub3 = 0;
  E3_MisP_Ub4 = 0;
  E3_MisP_Ub5 = 0;
  E3_MisP_Ub6 = 0;
  E3_MisP_Ub7 = 0;
  E3_MisP_Ub8 = 300/cytosol;
  MisP_Ub4_Proteasome = 0;
  MisP_Ub5_Proteasome = 1/cytosol;
  MisP_Ub6_Proteasome = 2/cytosol;
  MisP_Ub7_Proteasome = 10/cytosol;
  MisP_Ub8_Proteasome = 350/cytosol;
  E3_MisP_Ub_DUB = 100/cytosol;
  E3_MisP_Ub2_DUB = 100/cytosol;
  E3_MisP_Ub3_DUB = 100/cytosol;
  E3_MisP_Ub4_DUB = 100/cytosol;
  E3_MisP_Ub5_DUB = 100/cytosol;
  E3_MisP_Ub6_DUB = 100/cytosol;
  E3_MisP_Ub7_DUB = 100/cytosol;
  E3_MisP_Ub8_DUB = 100/cytosol;
  AggP1 = 0;
  AggP2 = 0;
  AggP3 = 0;
  AggP4 = 0;
  AggP5 = 0;
  SeqAggP = 0;
  AggP_Proteasome = 0;
  ATP = 10000/cytosol;
  ADP = 1000/cytosol;
  AMP = 1000/cytosol;
  UCHL1 = 5785/cytosol;
  UCHL1_Proteasome = 10/cytosol;
  UCHL1_damaged_Proteasome = 0;
  Lysosome = 1200/cytosol;
  UCHL1_damaged = 0;
  Lamp2a = 200/cytosol;
  Lamp2a_UCHL1_damaged = 0;
  Ub_UCHL1 = 500/cytosol;
  SUB = 815/cytosol;
  SUB_misfolded = 5/cytosol;
  E3SUB = 160/cytosol;
  E3SUB_SUB_misfolded = 5/cytosol;
  E3SUB_SUB_misfolded_Ub = 0;
  E3SUB_SUB_misfolded_Ub2 = 0;
  E3SUB_SUB_misfolded_Ub3 = 0;
  E3SUB_SUB_misfolded_Ub4 = 0;
  E3SUB_SUB_misfolded_Ub5 = 0;
  E3SUB_SUB_misfolded_Ub6 = 0;
  E3SUB_SUB_misfolded_Ub7 = 0;
  E3SUB_SUB_misfolded_Ub8 = 15/cytosol;
  E3SUB_SUB_misfolded_Ub_UCHL1 = 20/cytosol;
  E3SUB_SUB_misfolded_Ub2_UCHL1 = 20/cytosol;
  E3SUB_SUB_misfolded_Ub3_UCHL1 = 25/cytosol;
  E3SUB_SUB_misfolded_Ub4_UCHL1 = 25/cytosol;
  E3SUB_SUB_misfolded_Ub5_UCHL1 = 30/cytosol;
  E3SUB_SUB_misfolded_Ub6_UCHL1 = 30/cytosol;
  E3SUB_SUB_misfolded_Ub7_UCHL1 = 40/cytosol;
  E3SUB_SUB_misfolded_Ub8_UCHL1 = 40/cytosol;
  SUB_misfolded_Ub4_Proteasome = 0;
  SUB_misfolded_Ub5_Proteasome = 0;
  SUB_misfolded_Ub6_Proteasome = 0;
  SUB_misfolded_Ub7_Proteasome = 5/cytosol;
  SUB_misfolded_Ub8_Proteasome = 20/cytosol;
  asyn = 3000/cytosol;
  asyn_Proteasome = 0;
  asyn_Lamp2a = 0;
  asyn_dam = 0;
  Parkin = 4800/cytosol;
  Parkin_asyn_dam = 0;
  Parkin_asyn_dam_Ub = 0;
  Parkin_asyn_dam_Ub2 = 0;
  Parkin_asyn_dam_Ub3 = 0;
  Parkin_asyn_dam_Ub4 = 0;
  Parkin_asyn_dam_Ub5 = 0;
  Parkin_asyn_dam_Ub6 = 0;
  Parkin_asyn_dam_Ub7 = 0;
  Parkin_asyn_dam_Ub8 = 0;
  Parkin_asyn_dam_Ub_DUB = 0;
  Parkin_asyn_dam_Ub2_DUB = 0;
  Parkin_asyn_dam_Ub3_DUB = 0;
  Parkin_asyn_dam_Ub4_DUB = 0;
  Parkin_asyn_dam_Ub5_DUB = 0;
  Parkin_asyn_dam_Ub6_DUB = 0;
  Parkin_asyn_dam_Ub7_DUB = 0;
  Parkin_asyn_dam_Ub8_DUB = 0;
  asyn_dam_Ub4_Proteasome = 0;
  asyn_dam_Ub5_Proteasome = 0;
  asyn_dam_Ub6_Proteasome = 0;
  asyn_dam_Ub7_Proteasome = 0;
  asyn_dam_Ub8_Proteasome = 0;
  AggA1 = 0;
  AggA2 = 0;
  AggA3 = 0;
  AggA4 = 0;
  AggA5 = 0;
  AggD1 = 0;
  AggD2 = 0;
  AggD3 = 0;
  AggD4 = 0;
  AggD5 = 0;
  AggU1 = 0;
  AggU2 = 0;
  AggU3 = 0;
  AggU4 = 0;
  AggU5 = 0;
  AggS1 = 0;
  AggS2 = 0;
  AggS3 = 0;
  AggS4 = 0;
  AggS5 = 0;
  Source = 1/cytosol;
  Sink = 1/cytosol;
  aggasyn = 0;
  aggasyndam = 0;
  aggParkin = 0;
  aggUb = 0;
  aggE3 = 0;
  aggDUB = 0;
  aggMisP = 0;
  aggUchl1 = 0;
  aggUchl1dam = 0;
  aggSUB = 0;
  upregUb = 0;

  // Compartment initializations:
  cytosol = 1;

  // Variable initializations:
  ksynNatP = 2.4;
  kmisfold = 4e-05;
  krefold = 8e-05;
  kbinMisPE3 = 0.0001;
  krelMisPE3 = 0.0002;
  kbinE1Ub = 0.0002;
  kbinE2Ub = 0.001;
  kmonoUb = 0.001;
  kpolyUb = 0.01;
  kactDUB = 0.0001;
  kbinProt = 5e-06;
  kactDUBProt = 1e-06;
  kactProt = 0.01;
  kagg1 = 1e-12;
  kagg2 = 1e-10;
  kdisagg1 = 1e-08;
  kdisagg2 = 8e-09;
  kdisagg3 = 6e-09;
  kdisagg4 = 4e-09;
  kdisagg5 = 2e-09;
  kigrowth1 = 5e-09;
  kigrowth2 = 5e-09;
  kbinAggProt = 5e-09;
  kbinMisPDUB = 2e-07;
  kgenROS = 0.01;
  kremROS = 0.001;
  kubs = 0.009;
  kubd = 4.4e-09;
  kubss = 0.1;
  ksynUCHL1 = 0.022;
  kbinUCHL1Prot = 4e-10;
  kdegProtUCHL1 = 0.01;
  kdegLysUCHL1 = 2.7e-09;
  kdamUCHL1 = 1e-08;
  kbinLamp2aUCHL1dam = 1e-05;
  krelLamp2aUCHL1dam = 5e-05;
  kdegLysUCHL1dam = 2.7e-09;
  kbinUbUCHL1 = 3e-06;
  krelUbUCHL1 = 0.05;
  kactUchl1 = 0.0001;
  kbinSUBUCHL1 = 4e-08;
  ksynSUB = 0.13;
  kmisfoldSUB = 2e-05;
  krefoldSUB = 5e-05;
  kbinE3SUB = 0.0005;
  krelE3SUB = 0.0002;
  ksynasyn = 0.028;
  kbinasynProt = 1.7e-09;
  kdegasynProt = 0.01;
  kbinasynLamp2a = 4e-08;
  kCMAasyn = 0.001;
  kdamasyn = 5e-08;
  kbinasynDUB = 2e-07;
  kbinasynParkin = 0.0001;
  krelasynParkin = 0.0002;
  kaggasyn1 = 5e-12;
  kaggasyn2 = 5e-10;
  kdisaggasyn1 = 1e-08;
  kdisaggasyn2 = 8e-09;
  kdisaggasyn3 = 6e-09;
  kdisaggasyn4 = 4e-09;
  kdisaggasyn5 = 2e-09;
  kgenROSAggP = 2e-05;
  kagg1dam = 1e-05;
  kagg2dam = 0.005;
  kdisaggasyndam1 = 1e-08;
  kdisaggasyndam2 = 8e-09;
  kdisaggasyndam3 = 6e-09;
  kdisaggasyndam4 = 4e-09;
  kdisaggasyndam5 = 2e-09;
  kdisagguchl1dam1 = 1e-08;
  kdisagguchl1dam2 = 8e-09;
  kdisagguchl1dam3 = 6e-09;
  kdisagguchl1dam4 = 4e-09;
  kdisagguchl1dam5 = 2e-09;
  kaggSUB1 = 1e-12;
  kaggSUB2 = 1e-10;
  kdisaggSUB1 = 1e-08;
  kdisaggSUB2 = 8e-09;
  kdisaggSUB3 = 6e-09;
  kdisaggSUB4 = 4e-09;
  kdisaggSUB5 = 2e-09;
  kproteff = 1;

  // Other declarations:
  var kproteff, Tot_MisP, Tot_Protein, Ub_Conjugates, Tot_Ub, AggP, Tot_asyn_dam;
  var Tot_asyn, Tot_UCHL1, UCHL1_substrate;
  const cytosol, ksynNatP, kmisfold, krefold, kbinMisPE3, krelMisPE3, kbinE1Ub;
  const kbinE2Ub, kmonoUb, kpolyUb, kactDUB, kbinProt, kactDUBProt, kactProt;
  const kagg1, kagg2, kdisagg1, kdisagg2, kdisagg3, kdisagg4, kdisagg5, kigrowth1;
  const kigrowth2, kbinAggProt, kbinMisPDUB, kgenROS, kremROS, kubs, kubd;
  const kubss, ksynUCHL1, kbinUCHL1Prot, kdegProtUCHL1, kdegLysUCHL1, kdamUCHL1;
  const kbinLamp2aUCHL1dam, krelLamp2aUCHL1dam, kdegLysUCHL1dam, kbinUbUCHL1;
  const krelUbUCHL1, kactUchl1, kbinSUBUCHL1, ksynSUB, kmisfoldSUB, krefoldSUB;
  const kbinE3SUB, krelE3SUB, ksynasyn, kbinasynProt, kdegasynProt, kbinasynLamp2a;
  const kCMAasyn, kdamasyn, kbinasynDUB, kbinasynParkin, krelasynParkin, kaggasyn1;
  const kaggasyn2, kdisaggasyn1, kdisaggasyn2, kdisaggasyn3, kdisaggasyn4;
  const kdisaggasyn5, kgenROSAggP, kagg1dam, kagg2dam, kdisaggasyndam1, kdisaggasyndam2;
  const kdisaggasyndam3, kdisaggasyndam4, kdisaggasyndam5, kdisagguchl1dam1;
  const kdisagguchl1dam2, kdisagguchl1dam3, kdisagguchl1dam4, kdisagguchl1dam5;
  const kaggSUB1, kaggSUB2, kdisaggSUB1, kdisaggSUB2, kdisaggSUB3, kdisaggSUB4;
  const kdisaggSUB5;

  // Unit definitions:
  unit substance = item;

  // SBO terms:
  NatP.sboTerm = 245
  MisP.sboTerm = 245
  Ub.sboTerm = 245
  E1.sboTerm = 14
  E2.sboTerm = 14
  E3.sboTerm = 14
  E3_MisP.sboTerm = 296
  DUB.sboTerm = 14
  Proteasome.sboTerm = 296
  ROS.sboTerm = 245
  E1_Ub.sboTerm = 296
  E2_Ub.sboTerm = 296
  E3_MisP_Ub.sboTerm = 296
  E3_MisP_Ub2.sboTerm = 296
  E3_MisP_Ub3.sboTerm = 296
  E3_MisP_Ub4.sboTerm = 296
  E3_MisP_Ub5.sboTerm = 296
  E3_MisP_Ub6.sboTerm = 296
  E3_MisP_Ub7.sboTerm = 296
  E3_MisP_Ub8.sboTerm = 296
  MisP_Ub4_Proteasome.sboTerm = 296
  MisP_Ub5_Proteasome.sboTerm = 296
  MisP_Ub6_Proteasome.sboTerm = 296
  MisP_Ub7_Proteasome.sboTerm = 296
  MisP_Ub8_Proteasome.sboTerm = 296
  E3_MisP_Ub_DUB.sboTerm = 296
  E3_MisP_Ub2_DUB.sboTerm = 296
  E3_MisP_Ub3_DUB.sboTerm = 296
  E3_MisP_Ub4_DUB.sboTerm = 296
  E3_MisP_Ub5_DUB.sboTerm = 296
  E3_MisP_Ub6_DUB.sboTerm = 296
  E3_MisP_Ub7_DUB.sboTerm = 296
  E3_MisP_Ub8_DUB.sboTerm = 296
  AggP1.sboTerm = 543
  AggP2.sboTerm = 543
  AggP3.sboTerm = 543
  AggP4.sboTerm = 543
  AggP5.sboTerm = 543
  SeqAggP.sboTerm = 543
  AggP_Proteasome.sboTerm = 296
  ATP.sboTerm = 247
  ADP.sboTerm = 247
  AMP.sboTerm = 247
  UCHL1.sboTerm = 245
  UCHL1_Proteasome.sboTerm = 296
  UCHL1_damaged_Proteasome.sboTerm = 296
  Lysosome.sboTerm = 290
  UCHL1_damaged.sboTerm = 245
  Lamp2a.sboTerm = 245
  Lamp2a_UCHL1_damaged.sboTerm = 296
  Ub_UCHL1.sboTerm = 296
  SUB.sboTerm = 245
  SUB_misfolded.sboTerm = 245
  E3SUB.sboTerm = 14
  E3SUB_SUB_misfolded.sboTerm = 14
  E3SUB_SUB_misfolded_Ub.sboTerm = 296
  E3SUB_SUB_misfolded_Ub2.sboTerm = 296
  E3SUB_SUB_misfolded_Ub3.sboTerm = 296
  E3SUB_SUB_misfolded_Ub4.sboTerm = 296
  E3SUB_SUB_misfolded_Ub5.sboTerm = 296
  E3SUB_SUB_misfolded_Ub6.sboTerm = 296
  E3SUB_SUB_misfolded_Ub7.sboTerm = 296
  E3SUB_SUB_misfolded_Ub8.sboTerm = 296
  E3SUB_SUB_misfolded_Ub_UCHL1.sboTerm = 296
  E3SUB_SUB_misfolded_Ub2_UCHL1.sboTerm = 296
  E3SUB_SUB_misfolded_Ub3_UCHL1.sboTerm = 296
  E3SUB_SUB_misfolded_Ub4_UCHL1.sboTerm = 296
  E3SUB_SUB_misfolded_Ub5_UCHL1.sboTerm = 296
  E3SUB_SUB_misfolded_Ub6_UCHL1.sboTerm = 296
  E3SUB_SUB_misfolded_Ub7_UCHL1.sboTerm = 296
  E3SUB_SUB_misfolded_Ub8_UCHL1.sboTerm = 296
  SUB_misfolded_Ub4_Proteasome.sboTerm = 296
  SUB_misfolded_Ub5_Proteasome.sboTerm = 296
  SUB_misfolded_Ub6_Proteasome.sboTerm = 296
  SUB_misfolded_Ub7_Proteasome.sboTerm = 296
  SUB_misfolded_Ub8_Proteasome.sboTerm = 296
  asyn.sboTerm = 245
  asyn_Proteasome.sboTerm = 296
  asyn_Lamp2a.sboTerm = 296
  asyn_dam.sboTerm = 245
  Parkin.sboTerm = 245
  Parkin_asyn_dam.sboTerm = 296
  Parkin_asyn_dam_Ub.sboTerm = 296
  Parkin_asyn_dam_Ub2.sboTerm = 296
  Parkin_asyn_dam_Ub3.sboTerm = 296
  Parkin_asyn_dam_Ub4.sboTerm = 296
  Parkin_asyn_dam_Ub5.sboTerm = 296
  Parkin_asyn_dam_Ub6.sboTerm = 296
  Parkin_asyn_dam_Ub7.sboTerm = 296
  Parkin_asyn_dam_Ub8.sboTerm = 296
  Parkin_asyn_dam_Ub_DUB.sboTerm = 296
  Parkin_asyn_dam_Ub2_DUB.sboTerm = 296
  Parkin_asyn_dam_Ub3_DUB.sboTerm = 296
  Parkin_asyn_dam_Ub4_DUB.sboTerm = 296
  Parkin_asyn_dam_Ub5_DUB.sboTerm = 296
  Parkin_asyn_dam_Ub6_DUB.sboTerm = 296
  Parkin_asyn_dam_Ub7_DUB.sboTerm = 296
  Parkin_asyn_dam_Ub8_DUB.sboTerm = 296
  asyn_dam_Ub4_Proteasome.sboTerm = 296
  asyn_dam_Ub5_Proteasome.sboTerm = 296
  asyn_dam_Ub6_Proteasome.sboTerm = 296
  asyn_dam_Ub7_Proteasome.sboTerm = 296
  asyn_dam_Ub8_Proteasome.sboTerm = 296
  AggA1.sboTerm = 543
  AggA2.sboTerm = 543
  AggA3.sboTerm = 543
  AggA4.sboTerm = 543
  AggA5.sboTerm = 543
  AggD1.sboTerm = 543
  AggD2.sboTerm = 543
  AggD3.sboTerm = 543
  AggD4.sboTerm = 543
  AggD5.sboTerm = 543
  AggU1.sboTerm = 543
  AggU2.sboTerm = 543
  AggU3.sboTerm = 543
  AggU4.sboTerm = 543
  AggU5.sboTerm = 543
  AggS1.sboTerm = 543
  AggS2.sboTerm = 543
  AggS3.sboTerm = 543
  AggS4.sboTerm = 543
  AggS5.sboTerm = 543
  Source.sboTerm = 291
  Sink.sboTerm = 291
  aggasyn.sboTerm = 543
  aggasyndam.sboTerm = 543
  aggParkin.sboTerm = 543
  aggUb.sboTerm = 543
  aggE3.sboTerm = 543
  aggDUB.sboTerm = 543
  aggMisP.sboTerm = 543
  aggUchl1.sboTerm = 543
  aggUchl1dam.sboTerm = 543
  aggSUB.sboTerm = 543
  upregUb.sboTerm = 245
  ksynNatP.sboTerm = 153
  kmisfold.sboTerm = 153
  krefold.sboTerm = 156
  kbinMisPE3.sboTerm = 153
  krelMisPE3.sboTerm = 156
  kbinE1Ub.sboTerm = 9
  kbinE2Ub.sboTerm = 9
  kmonoUb.sboTerm = 9
  kpolyUb.sboTerm = 9
  kactDUB.sboTerm = 9
  kbinProt.sboTerm = 9
  kactDUBProt.sboTerm = 9
  kactProt.sboTerm = 9
  kagg1.sboTerm = 9
  kagg2.sboTerm = 9
  kdisagg1.sboTerm = 9
  kdisagg2.sboTerm = 9
  kdisagg3.sboTerm = 9
  kdisagg4.sboTerm = 9
  kdisagg5.sboTerm = 9
  kigrowth1.sboTerm = 9
  kigrowth2.sboTerm = 9
  kbinAggProt.sboTerm = 9
  kbinMisPDUB.sboTerm = 9
  kgenROS.sboTerm = 9
  kremROS.sboTerm = 9
  kubs.sboTerm = 9
  kubd.sboTerm = 9
  kubss.sboTerm = 9
  ksynUCHL1.sboTerm = 9
  kbinUCHL1Prot.sboTerm = 9
  kdegProtUCHL1.sboTerm = 9
  kdegLysUCHL1.sboTerm = 9
  kdamUCHL1.sboTerm = 9
  kbinLamp2aUCHL1dam.sboTerm = 9
  krelLamp2aUCHL1dam.sboTerm = 9
  kdegLysUCHL1dam.sboTerm = 9
  kbinUbUCHL1.sboTerm = 9
  krelUbUCHL1.sboTerm = 9
  kactUchl1.sboTerm = 9
  kbinSUBUCHL1.sboTerm = 9
  ksynSUB.sboTerm = 9
  kmisfoldSUB.sboTerm = 9
  krefoldSUB.sboTerm = 9
  kbinE3SUB.sboTerm = 9
  krelE3SUB.sboTerm = 9
  ksynasyn.sboTerm = 9
  kbinasynProt.sboTerm = 9
  kdegasynProt.sboTerm = 9
  kbinasynLamp2a.sboTerm = 9
  kCMAasyn.sboTerm = 9
  kdamasyn.sboTerm = 9
  kbinasynDUB.sboTerm = 9
  kbinasynParkin.sboTerm = 9
  krelasynParkin.sboTerm = 9
  kaggasyn1.sboTerm = 9
  kaggasyn2.sboTerm = 9
  kdisaggasyn1.sboTerm = 9
  kdisaggasyn2.sboTerm = 9
  kdisaggasyn3.sboTerm = 9
  kdisaggasyn4.sboTerm = 9
  kdisaggasyn5.sboTerm = 9
  kgenROSAggP.sboTerm = 9
  kagg1dam.sboTerm = 9
  kagg2dam.sboTerm = 9
  kdisaggasyndam1.sboTerm = 9
  kdisaggasyndam2.sboTerm = 9
  kdisaggasyndam3.sboTerm = 9
  kdisaggasyndam4.sboTerm = 9
  kdisaggasyndam5.sboTerm = 9
  kdisagguchl1dam1.sboTerm = 9
  kdisagguchl1dam2.sboTerm = 9
  kdisagguchl1dam3.sboTerm = 9
  kdisagguchl1dam4.sboTerm = 9
  kdisagguchl1dam5.sboTerm = 9
  kaggSUB1.sboTerm = 9
  kaggSUB2.sboTerm = 9
  kdisaggSUB1.sboTerm = 9
  kdisaggSUB2.sboTerm = 9
  kdisaggSUB3.sboTerm = 9
  kdisaggSUB4.sboTerm = 9
  kdisaggSUB5.sboTerm = 9
  kproteff.sboTerm = 9
  Tot_MisP.sboTerm = 360
  Tot_Protein.sboTerm = 360
  Ub_Conjugates.sboTerm = 360
  Tot_Ub.sboTerm = 360
  AggP.sboTerm = 360
  Tot_asyn_dam.sboTerm = 360
  Tot_asyn.sboTerm = 360
  Tot_UCHL1.sboTerm = 360
  UCHL1_substrate.sboTerm = 360
  UbSynthesis.sboTerm = 393
  UbDegradation.sboTerm = 179
  UbUpregulation.sboTerm = 375
  ProteinSynthesis.sboTerm = 393
  Misfolding.sboTerm = 375
  Refolding.sboTerm = 375
  MisPE3Binding.sboTerm = 526
  MisPE3Release.sboTerm = 180
  E1UbBinding.sboTerm = 526
  E2UbBinding.sboTerm = 526
  Monoubiquitination.sboTerm = 526
  Polyubiquitination1.sboTerm = 526
  Polyubiquitination2.sboTerm = 526
  Polyubiquitination3.sboTerm = 526
  Polyubiquitination4.sboTerm = 526
  Polyubiquitination5.sboTerm = 526
  Polyubiquitination6.sboTerm = 526
  Polyubiquitination7.sboTerm = 526
  MisPDUBbinding1.sboTerm = 526
  MisPDUBbinding2.sboTerm = 526
  MisPDUBbinding3.sboTerm = 526
  MisPDUBbinding4.sboTerm = 526
  MisPDUBbinding5.sboTerm = 526
  MisPDUBbinding6.sboTerm = 526
  MisPDUBbinding7.sboTerm = 526
  MisPDUBbinding8.sboTerm = 526
  Deubiquitination8.sboTerm = 180
  Deubiquitination7.sboTerm = 180
  Deubiquitination6.sboTerm = 180
  Deubiquitination5.sboTerm = 180
  Deubiquitination4.sboTerm = 180
  Deubiquitination3.sboTerm = 180
  Deubiquitination2.sboTerm = 180
  Deubiquitination1.sboTerm = 180
  ProteasomeBindingUb4.sboTerm = 526
  ProteasomeBindingUb5.sboTerm = 526
  ProteasomeBindingUb6.sboTerm = 526
  ProteasomeBindingUb7.sboTerm = 526
  ProteasomeBindingUb8.sboTerm = 526
  DeubiquitinationBoundMisP5.sboTerm = 180
  DeubiquitinationBoundMisP4.sboTerm = 180
  DeubiquitinationBoundMisP3.sboTerm = 180
  DeubiquitinationBoundMisP2.sboTerm = 180
  DeubiquitinationBoundMisP1.sboTerm = 180
  ProteasomeActivity1.sboTerm = 179
  ProteasomeActivity2.sboTerm = 179
  ProteasomeActivity3.sboTerm = 179
  ProteasomeActivity4.sboTerm = 179
  ProteasomeActivity5.sboTerm = 179

  // CV terms:
  NatP hypernym "http://identifiers.org/chebi/CHEBI:36080"
  MisP hypernym "http://identifiers.org/chebi/CHEBI:36080"
  Ub hypernym "http://identifiers.org/uniprot/P62988"
  E1 hypernym "http://identifiers.org/interpro/IPR000011"
  E2 hypernym "http://identifiers.org/interpro/IPR000608"
  E3 hypernym "http://identifiers.org/interpro/IPR000569"
  E3_MisP part "http://identifiers.org/chebi/CHEBI:36080",
               "http://identifiers.org/interpro/IPR000569"
  DUB hypernym "http://identifiers.org/interpro/IPR001394"
  Proteasome hypernym "http://identifiers.org/go/GO:0000502"
  ROS hypernym "http://identifiers.org/chebi/CHEBI:26523"
  E1_Ub part "http://identifiers.org/uniprot/P62988",
             "http://identifiers.org/interpro/IPR000011"
  E2_Ub part "http://identifiers.org/uniprot/P62988",
             "http://identifiers.org/interpro/IPR000608"
  E3_MisP_Ub part "http://identifiers.org/chebi/CHEBI:36080",
                  "http://identifiers.org/uniprot/P62988",
                  "http://identifiers.org/interpro/IPR000569"
  E3_MisP_Ub2 part "http://identifiers.org/chebi/CHEBI:36080",
                   "http://identifiers.org/uniprot/P62988",
                   "http://identifiers.org/interpro/IPR000569"
  E3_MisP_Ub3 part "http://identifiers.org/chebi/CHEBI:36080",
                   "http://identifiers.org/uniprot/P62988",
                   "http://identifiers.org/interpro/IPR000569"
  E3_MisP_Ub4 part "http://identifiers.org/chebi/CHEBI:36080",
                   "http://identifiers.org/uniprot/P62988",
                   "http://identifiers.org/interpro/IPR000569"
  E3_MisP_Ub5 part "http://identifiers.org/chebi/CHEBI:36080",
                   "http://identifiers.org/uniprot/P62988",
                   "http://identifiers.org/interpro/IPR000569"
  E3_MisP_Ub6 part "http://identifiers.org/chebi/CHEBI:36080",
                   "http://identifiers.org/uniprot/P62988",
                   "http://identifiers.org/interpro/IPR000569"
  E3_MisP_Ub7 part "http://identifiers.org/chebi/CHEBI:36080",
                   "http://identifiers.org/uniprot/P62988",
                   "http://identifiers.org/interpro/IPR000569"
  E3_MisP_Ub8 part "http://identifiers.org/chebi/CHEBI:36080",
                   "http://identifiers.org/uniprot/P62988",
                   "http://identifiers.org/interpro/IPR000569"
  MisP_Ub4_Proteasome identity "http://identifiers.org/chebi/CHEBI:36080",
                               "http://identifiers.org/uniprot/P62988"
  MisP_Ub5_Proteasome part "http://identifiers.org/chebi/CHEBI:36080",
                           "http://identifiers.org/uniprot/P62988",
                           "http://identifiers.org/go/GO:0000502"
  MisP_Ub6_Proteasome part "http://identifiers.org/chebi/CHEBI:36080",
                           "http://identifiers.org/uniprot/P62988",
                           "http://identifiers.org/go/GO:0000502"
  MisP_Ub7_Proteasome part "http://identifiers.org/chebi/CHEBI:36080",
                           "http://identifiers.org/uniprot/P62988",
                           "http://identifiers.org/go/GO:0000502"
  MisP_Ub8_Proteasome part "http://identifiers.org/chebi/CHEBI:36080",
                           "http://identifiers.org/uniprot/P62988",
                           "http://identifiers.org/go/GO:0000502"
  E3_MisP_Ub_DUB part "http://identifiers.org/chebi/CHEBI:36080",
                      "http://identifiers.org/uniprot/P62988",
                      "http://identifiers.org/interpro/IPR001394",
                      "http://identifiers.org/interpro/IPR000569"
  E3_MisP_Ub2_DUB part "http://identifiers.org/chebi/CHEBI:36080",
                       "http://identifiers.org/uniprot/P62988",
                       "http://identifiers.org/interpro/IPR001394",
                       "http://identifiers.org/interpro/IPR000569"
  E3_MisP_Ub3_DUB part "http://identifiers.org/chebi/CHEBI:36080",
                       "http://identifiers.org/uniprot/P62988",
                       "http://identifiers.org/interpro/IPR001394",
                       "http://identifiers.org/interpro/IPR000569"
  E3_MisP_Ub4_DUB part "http://identifiers.org/chebi/CHEBI:36080",
                       "http://identifiers.org/uniprot/P62988",
                       "http://identifiers.org/interpro/IPR001394",
                       "http://identifiers.org/interpro/IPR000569"
  E3_MisP_Ub5_DUB part "http://identifiers.org/chebi/CHEBI:36080",
                       "http://identifiers.org/uniprot/P62988",
                       "http://identifiers.org/interpro/IPR001394",
                       "http://identifiers.org/interpro/IPR000569"
  E3_MisP_Ub6_DUB part "http://identifiers.org/chebi/CHEBI:36080",
                       "http://identifiers.org/uniprot/P62988",
                       "http://identifiers.org/interpro/IPR001394",
                       "http://identifiers.org/interpro/IPR000569"
  E3_MisP_Ub7_DUB part "http://identifiers.org/chebi/CHEBI:36080",
                       "http://identifiers.org/uniprot/P62988",
                       "http://identifiers.org/interpro/IPR001394",
                       "http://identifiers.org/interpro/IPR000569"
  E3_MisP_Ub8_DUB part "http://identifiers.org/chebi/CHEBI:36080",
                       "http://identifiers.org/uniprot/P62988",
                       "http://identifiers.org/interpro/IPR001394",
                       "http://identifiers.org/interpro/IPR000569"
  AggP_Proteasome part "http://identifiers.org/go/GO:0000502"
  ATP hypernym "http://identifiers.org/chebi/CHEBI:15422"
  ADP hypernym "http://identifiers.org/chebi/CHEBI:16761"
  AMP hypernym "http://identifiers.org/chebi/CHEBI:16027"
  UCHL1 hypernym "http://identifiers.org/uniprot/P09936"
  UCHL1_Proteasome part "http://identifiers.org/uniprot/P09936",
                        "http://identifiers.org/go/GO:0000502"
  UCHL1_damaged_Proteasome part "http://identifiers.org/uniprot/P09936",
                                "http://identifiers.org/go/GO:0000502"
  Lysosome hypernym "http://identifiers.org/go/GO:0005764"
  UCHL1_damaged hypernym "http://identifiers.org/uniprot/P09936"
  Lamp2a hypernym "http://identifiers.org/uniprot/P13473"
  Lamp2a_UCHL1_damaged hypernym "http://identifiers.org/uniprot/P09936",
                                "http://identifiers.org/uniprot/P13473"
  Ub_UCHL1 part "http://identifiers.org/uniprot/P09936",
                "http://identifiers.org/uniprot/P62988"
  E3SUB hypernym "http://identifiers.org/interpro/IPR000569"
  E3SUB_SUB_misfolded hypernym "http://identifiers.org/interpro/IPR000569"
  E3SUB_SUB_misfolded_Ub part "http://identifiers.org/uniprot/P62988",
                              "http://identifiers.org/interpro/IPR000569"
  E3SUB_SUB_misfolded_Ub2 part "http://identifiers.org/uniprot/P62988",
                               "http://identifiers.org/interpro/IPR000569"
  E3SUB_SUB_misfolded_Ub3 part "http://identifiers.org/uniprot/P62988",
                               "http://identifiers.org/interpro/IPR000569"
  E3SUB_SUB_misfolded_Ub4 part "http://identifiers.org/uniprot/P62988",
                               "http://identifiers.org/interpro/IPR000569"
  E3SUB_SUB_misfolded_Ub5 part "http://identifiers.org/uniprot/P62988",
                               "http://identifiers.org/interpro/IPR000569"
  E3SUB_SUB_misfolded_Ub6 identity "http://identifiers.org/uniprot/P62988",
                                   "http://identifiers.org/interpro/IPR000569"
  E3SUB_SUB_misfolded_Ub7 part "http://identifiers.org/uniprot/P62988",
                               "http://identifiers.org/interpro/IPR000569"
  E3SUB_SUB_misfolded_Ub8 part "http://identifiers.org/uniprot/P62988",
                               "http://identifiers.org/interpro/IPR000569"
  E3SUB_SUB_misfolded_Ub_UCHL1 part "http://identifiers.org/uniprot/P09936",
                                    "http://identifiers.org/uniprot/P62988",
                                    "http://identifiers.org/interpro/IPR000569"
  E3SUB_SUB_misfolded_Ub2_UCHL1 part "http://identifiers.org/uniprot/P09936",
                                     "http://identifiers.org/uniprot/P62988",
                                     "http://identifiers.org/interpro/IPR000569"
  E3SUB_SUB_misfolded_Ub3_UCHL1 part "http://identifiers.org/uniprot/P09936",
                                     "http://identifiers.org/uniprot/P62988",
                                     "http://identifiers.org/interpro/IPR000569"
  E3SUB_SUB_misfolded_Ub4_UCHL1 part "http://identifiers.org/uniprot/P09936",
                                     "http://identifiers.org/uniprot/P62988",
                                     "http://identifiers.org/interpro/IPR000569"
  E3SUB_SUB_misfolded_Ub5_UCHL1 part "http://identifiers.org/uniprot/P09936",
                                     "http://identifiers.org/uniprot/P62988",
                                     "http://identifiers.org/interpro/IPR000569"
  E3SUB_SUB_misfolded_Ub6_UCHL1 part "http://identifiers.org/uniprot/P09936",
                                     "http://identifiers.org/uniprot/P62988",
                                     "http://identifiers.org/interpro/IPR000569"
  E3SUB_SUB_misfolded_Ub7_UCHL1 part "http://identifiers.org/uniprot/P09936",
                                     "http://identifiers.org/uniprot/P62988",
                                     "http://identifiers.org/interpro/IPR000569"
  E3SUB_SUB_misfolded_Ub8_UCHL1 part "http://identifiers.org/uniprot/P09936",
                                     "http://identifiers.org/uniprot/P62988",
                                     "http://identifiers.org/interpro/IPR000569"
  SUB_misfolded_Ub4_Proteasome part "http://identifiers.org/uniprot/P62988",
                                    "http://identifiers.org/go/GO:0000502"
  SUB_misfolded_Ub5_Proteasome part "http://identifiers.org/uniprot/P62988",
                                    "http://identifiers.org/go/GO:0000502"
  SUB_misfolded_Ub6_Proteasome part "http://identifiers.org/uniprot/P62988",
                                    "http://identifiers.org/go/GO:0000502"
  SUB_misfolded_Ub7_Proteasome part "http://identifiers.org/uniprot/P62988",
                                    "http://identifiers.org/go/GO:0000502"
  SUB_misfolded_Ub8_Proteasome part "http://identifiers.org/uniprot/P62988",
                                    "http://identifiers.org/go/GO:0000502"
  asyn hypernym "http://identifiers.org/uniprot/P37840"
  asyn_Proteasome part "http://identifiers.org/uniprot/P37840",
                       "http://identifiers.org/go/GO:0000502"
  asyn_Lamp2a part "http://identifiers.org/uniprot/P13473",
                   "http://identifiers.org/uniprot/P37840"
  asyn_dam hypernym "http://identifiers.org/uniprot/P37840"
  Parkin hypernym "http://identifiers.org/uniprot/O60260"
  Parkin_asyn_dam part "http://identifiers.org/uniprot/O60260",
                       "http://identifiers.org/uniprot/P37840"
  Parkin_asyn_dam_Ub part "http://identifiers.org/uniprot/O60260",
                          "http://identifiers.org/uniprot/P37840",
                          "http://identifiers.org/uniprot/P62988"
  Parkin_asyn_dam_Ub2 part "http://identifiers.org/uniprot/O60260",
                           "http://identifiers.org/uniprot/P37840",
                           "http://identifiers.org/uniprot/P62988"
  Parkin_asyn_dam_Ub3 part "http://identifiers.org/uniprot/O60260",
                           "http://identifiers.org/uniprot/P37840",
                           "http://identifiers.org/uniprot/P62988"
  Parkin_asyn_dam_Ub4 part "http://identifiers.org/uniprot/O60260",
                           "http://identifiers.org/uniprot/P37840",
                           "http://identifiers.org/uniprot/P62988"
  Parkin_asyn_dam_Ub5 part "http://identifiers.org/uniprot/O60260",
                           "http://identifiers.org/uniprot/P37840",
                           "http://identifiers.org/uniprot/P62988"
  Parkin_asyn_dam_Ub6 part "http://identifiers.org/uniprot/O60260",
                           "http://identifiers.org/uniprot/P37840",
                           "http://identifiers.org/uniprot/P62988"
  Parkin_asyn_dam_Ub7 part "http://identifiers.org/uniprot/O60260",
                           "http://identifiers.org/uniprot/P37840",
                           "http://identifiers.org/uniprot/P62988"
  Parkin_asyn_dam_Ub8 part "http://identifiers.org/uniprot/O60260",
                           "http://identifiers.org/uniprot/P37840",
                           "http://identifiers.org/uniprot/P62988"
  Parkin_asyn_dam_Ub_DUB part "http://identifiers.org/uniprot/O60260",
                              "http://identifiers.org/uniprot/P37840",
                              "http://identifiers.org/uniprot/P62988"
  Parkin_asyn_dam_Ub2_DUB part "http://identifiers.org/uniprot/O60260",
                               "http://identifiers.org/uniprot/P37840",
                               "http://identifiers.org/uniprot/P62988"
  Parkin_asyn_dam_Ub3_DUB part "http://identifiers.org/uniprot/O60260",
                               "http://identifiers.org/uniprot/P37840",
                               "http://identifiers.org/uniprot/P62988"
  Parkin_asyn_dam_Ub4_DUB part "http://identifiers.org/uniprot/O60260",
                               "http://identifiers.org/uniprot/P37840",
                               "http://identifiers.org/uniprot/P62988"
  Parkin_asyn_dam_Ub5_DUB part "http://identifiers.org/uniprot/O60260",
                               "http://identifiers.org/uniprot/P37840",
                               "http://identifiers.org/uniprot/P62988"
  Parkin_asyn_dam_Ub6_DUB part "http://identifiers.org/uniprot/O60260",
                               "http://identifiers.org/uniprot/P37840",
                               "http://identifiers.org/uniprot/P62988"
  Parkin_asyn_dam_Ub7_DUB part "http://identifiers.org/uniprot/O60260",
                               "http://identifiers.org/uniprot/P37840",
                               "http://identifiers.org/uniprot/P62988"
  Parkin_asyn_dam_Ub8_DUB part "http://identifiers.org/uniprot/O60260",
                               "http://identifiers.org/uniprot/P37840",
                               "http://identifiers.org/uniprot/P62988"
  asyn_dam_Ub4_Proteasome part "http://identifiers.org/uniprot/P37840",
                               "http://identifiers.org/uniprot/P62988",
                               "http://identifiers.org/go/GO:0000502"
  asyn_dam_Ub5_Proteasome part "http://identifiers.org/uniprot/P37840",
                               "http://identifiers.org/uniprot/P62988",
                               "http://identifiers.org/go/GO:0000502"
  asyn_dam_Ub6_Proteasome part "http://identifiers.org/uniprot/P37840",
                               "http://identifiers.org/uniprot/P62988",
                               "http://identifiers.org/go/GO:0000502"
  asyn_dam_Ub7_Proteasome part "http://identifiers.org/uniprot/P37840",
                               "http://identifiers.org/uniprot/P62988",
                               "http://identifiers.org/go/GO:0000502"
  asyn_dam_Ub8_Proteasome part "http://identifiers.org/uniprot/P37840",
                               "http://identifiers.org/uniprot/P62988",
                               "http://identifiers.org/go/GO:0000502"
  AggA1 hypernym "http://identifiers.org/uniprot/P37840"
  AggA2 hypernym "http://identifiers.org/uniprot/P37840"
  AggA3 hypernym "http://identifiers.org/uniprot/P37840"
  AggA4 hypernym "http://identifiers.org/uniprot/P37840"
  AggA5 hypernym "http://identifiers.org/uniprot/P37840"
  AggD1 hypernym "http://identifiers.org/uniprot/P37840"
  AggD2 hypernym "http://identifiers.org/uniprot/P37840"
  AggD3 hypernym "http://identifiers.org/uniprot/P37840"
  AggD4 hypernym "http://identifiers.org/uniprot/P37840"
  AggD5 hypernym "http://identifiers.org/uniprot/P37840"
  AggU1 hypernym "http://identifiers.org/uniprot/P09936"
  AggU2 hypernym "http://identifiers.org/uniprot/P09936"
  AggU3 hypernym "http://identifiers.org/uniprot/P09936"
  AggU4 hypernym "http://identifiers.org/uniprot/P09936"
  AggU5 parthood "http://identifiers.org/uniprot/P09936"
  aggasyn hypernym "http://identifiers.org/uniprot/P37840"
  aggasyndam hypernym "http://identifiers.org/uniprot/P37840"
  aggParkin hypernym "http://identifiers.org/uniprot/O60260"
  aggUb hypernym "http://identifiers.org/uniprot/P62988"
  aggE3 hypernym "http://identifiers.org/interpro/IPR000569"
  aggDUB hypernym "http://identifiers.org/interpro/IPR001394"
  aggUchl1 hypernym "http://identifiers.org/uniprot/P09936"
  aggUchl1dam hypernym "http://identifiers.org/uniprot/P09936"
  upregUb hypernym "http://identifiers.org/uniprot/P62988"
end

Proctor2010_UCHL1_ProteinAggregation is "Proctor2010 - UCHL1 Protein Aggregation"

Proctor2010_UCHL1_ProteinAggregation model_entity_is "http://identifiers.org/biomodels.db/MODEL0912070000"
Proctor2010_UCHL1_ProteinAggregation model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000293"
Proctor2010_UCHL1_ProteinAggregation description "http://identifiers.org/pubmed/20949132"
Proctor2010_UCHL1_ProteinAggregation origin "http://identifiers.org/biomodels.db/BIOMD0000000105"
Proctor2010_UCHL1_ProteinAggregation hypernym "http://identifiers.org/go/GO:0004843",
                                              "http://identifiers.org/go/GO:0070841",
                                              "http://identifiers.org/go/GO:0032435"
Proctor2010_UCHL1_ProteinAggregation parthood "http://identifiers.org/kegg.pathway/ko05012"
Proctor2010_UCHL1_ProteinAggregation taxon "http://identifiers.org/taxonomy/9606"
Proctor2010_UCHL1_ProteinAggregation version "http://identifiers.org/doid/DOID:1289"
Proctor2010_UCHL1_ProteinAggregation property "http://identifiers.org/doid/DOID:14330"
