// Created by libAntimony v2.13.0
model *Lebeda2008_BoNT_Paralysis_3stepModel()

  // Compartments and Species:
  compartment extracellular, endosome, neuroplasm;
  species free in extracellular, bound in extracellular, translocate in endosome;
  species lytic in neuroplasm;

  // Assignment Rules:
  tension := 1 - lytic;

  // Reactions:
  endocytosis: bound => translocate; endocytosis_kT*bound*extracellular;
  translocation: translocate => lytic; translocation_kL*translocate*endosome;
  binding: free => bound; binding_kB*free*extracellular;

  // Species initializations:
  free = 1;
  bound = 0;
  translocate = 0;
  lytic = 0;

  // Compartment initializations:
  extracellular = 1;
  endosome = 1;
  neuroplasm = 1;

  // Variable initializations:
  endocytosis_kT = 0.141;
  endocytosis_kT has pmin;
  translocation_kL = 0.013;
  translocation_kL has pmin;
  binding_kB = 0.058;
  binding_kB has pmin;

  // Other declarations:
  var tension;
  const extracellular, endosome, neuroplasm;

  // Unit definitions:
  unit substance = dimensionless;
  unit volume = dimensionless;
  unit time_unit = 60 second;
  unit pmin = 1 / 60 second;

  // Display Names:
  substance is "relative concentration";
  volume is "normalized volume";
  time_unit is "min";
  pmin is "perminute";
  free is "free_BoNT/A";
  bound is "bound_BoNT/A";
  translocate is "transloc_BoNT/A";
  lytic is "lytic_BoNT/A";

  // CV terms:
  extracellular identity "http://identifiers.org/go/GO:0005615"
  endosome identity "http://identifiers.org/go/GO:0031904"
  neuroplasm hypernym "http://identifiers.org/go/GO:0005829",
                      "http://identifiers.org/go/GO:0043679"
  free identity "http://identifiers.org/kegg.compound/C07946"
  bound part "http://identifiers.org/kegg.compound/C07946"
  translocate part "http://identifiers.org/kegg.compound/C07946"
  lytic hypernym "http://identifiers.org/kegg.compound/C07946"
  endocytosis homolog "http://identifiers.org/reactome/REACT_11086.1"
  translocation hypernym "http://identifiers.org/reactome/REACT_11085.1"
  binding hypernym "http://identifiers.org/reactome/REACT_11084.1"
end

Lebeda2008_BoNT_Paralysis_3stepModel is "Lebeda2008 - BoNT paralysis (3 step model)"

Lebeda2008_BoNT_Paralysis_3stepModel model_entity_is "http://identifiers.org/biomodels.db/MODEL1009070000"
Lebeda2008_BoNT_Paralysis_3stepModel model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000267"
Lebeda2008_BoNT_Paralysis_3stepModel description "http://identifiers.org/pubmed/18551355"
Lebeda2008_BoNT_Paralysis_3stepModel origin "http://identifiers.org/pubmed/6243359"
Lebeda2008_BoNT_Paralysis_3stepModel hypernym "http://identifiers.org/reactome/REACT_11184.1",
                                              "http://identifiers.org/go/GO:0009405",
                                              "http://identifiers.org/go/GO:0006898",
                                              "http://identifiers.org/go/GO:0033264",
                                              "http://identifiers.org/go/GO:0032223"
Lebeda2008_BoNT_Paralysis_3stepModel taxon "http://identifiers.org/taxonomy/9606",
                                           "http://identifiers.org/taxonomy/10116",
                                           "http://identifiers.org/taxonomy/10090"
Lebeda2008_BoNT_Paralysis_3stepModel property "http://identifiers.org/doid/DOID:11976"
