// Created by libAntimony v2.13.0
model *Singh2006_TCA_mtu_model1()

  // Compartments and Species:
  compartment cell;
  species $aca in cell, $oaa in cell, $coa in cell, cit in cell, icit in cell;
  species akg in cell, ssa in cell, suc in cell, sca in cell, fa in cell;
  species mal in cell, gly in cell, $biosyn in cell;

  // Reactions:
  CS: $aca + $oaa -> $coa + cit; cell*((CS_Vf_cs*(aca/CS_Kaca_cs)*(oaa/CS_Koaa_cs) - CS_Vr_cs*(coa/CS_Kcoa_cs)*(cit/CS_Kcit_cs))/((1 + aca/CS_Kaca_cs + coa/CS_Kcoa_cs)*(1 + oaa/CS_Koaa_cs + cit/CS_Kcit_cs)));
  ACN: cit -> icit; cell*((ACN_Vf_acn*(cit/ACN_Kcit_acn) - ACN_Vr_acn*(icit/ACN_Kicit_acn))/(1 + cit/ACN_Kcit_acn + icit/ACN_Kicit_acn));
  ICD1: icit -> akg; cell*((ICD1_Vf_icd1*(icit/ICD1_Kicit_icd1) - ICD1_Vr_icd1*(akg/ICD1_Kakg_icd1))/(1 + icit/ICD1_Kicit_icd1 + akg/ICD1_Kakg_icd1));
  ICD2: icit -> akg; cell*((ICD2_Vf_icd2*(icit/ICD2_Kicit_icd2) - ICD2_Vr_icd2*(akg/ICD2_Kakg_icd2))/(1 + icit/ICD2_Kicit_icd2 + akg/ICD2_Kakg_icd2));
  KDH: akg -> sca; cell*((KDH_Vf_kdh*(akg/KDH_Kakg_kdh) - KDH_Vr_kdh*(sca/KDH_Ksca_kdh))/(1 + akg/KDH_Kakg_kdh + sca/KDH_Ksca_kdh));
  KGD: akg -> ssa; cell*((KGD_Vf_kgd*(akg/KGD_Kakg_kgd) - KGD_Vr_kgd*(ssa/KGD_Kssa_kgd))/(1 + akg/KGD_Kakg_kgd + ssa/KGD_Kssa_kgd));
  SSADH: ssa -> suc; cell*((SSADH_Vf_ssadh*(ssa/SSADH_Kssa_ssadh) - SSADH_Vr_ssadh*(suc/SSADH_Ksuc_ssadh))/(1 + ssa/SSADH_Kssa_ssadh + suc/SSADH_Ksuc_ssadh));
  ScAS: sca -> suc; cell*((ScAS_Vf_scas*(sca/ScAS_Ksca_scas) - ScAS_Vr_scas*(suc/ScAS_Ksuc_scas))/(1 + sca/ScAS_Ksca_scas + suc/ScAS_Ksuc_scas));
  SDH: suc -> fa; cell*((SDH_Vf_sdh*(suc/SDH_Ksuc_sdh) - SDH_Vr_sdh*(fa/SDH_Kfa_sdh))/(1 + suc/SDH_Ksuc_sdh + fa/SDH_Kfa_sdh));
  FUM: fa -> mal; cell*((FUM_Vf_fum*(fa/FUM_Kfa_fum) - FUM_Vr_fum*(mal/FUM_Kmal_fum))/(1 + fa/FUM_Kfa_fum + mal/FUM_Kmal_fum));
  MDH: mal -> $oaa; cell*((MDH_Vf_mdh*(mal/MDH_Kmal_mdh) - MDH_Vr_mdh*(oaa/MDH_Koaa_mdh))/(1 + mal/MDH_Kmal_mdh + oaa/MDH_Koaa_mdh));
  ICL1: icit -> suc + gly; cell*((ICL1_Vf_icl1*(icit/ICL1_Kicit_icl1) - ICL1_Vr_icl1*(suc/ICL1_Ksuc_icl1)*(gly/ICL1_Kgly_icl1))/(1 + icit/ICL1_Kicit_icl1 + suc/ICL1_Ksuc_icl1 + gly/ICL1_Kgly_icl1 + (icit/ICL1_Kicit_icl1)*(suc/ICL1_Ksuc_icl1) + (suc/ICL1_Ksuc_icl1)*(gly/ICL1_Kgly_icl1)));
  ICL2: icit -> suc + gly; cell*((ICL2_Vf_icl2*(icit/ICL2_Kicit_icl2) - ICL2_Vr_icl2*(suc/ICL2_Ksuc_icl2)*(gly/ICL2_Kgly_icl2))/(1 + icit/ICL2_Kicit_icl2 + suc/ICL2_Ksuc_icl2 + gly/ICL2_Kgly_icl2 + (icit/ICL2_Kicit_icl2)*(suc/ICL2_Ksuc_icl2) + (suc/ICL2_Ksuc_icl2)*(gly/ICL2_Kgly_icl2)));
  MS: gly + $aca -> mal + $coa; cell*((MS_Vf_ms*(gly/MS_Kgly_ms)*(aca/MS_Kaca_ms) - MS_Vr_ms*(mal/MS_Kmal_ms)*(coa/MS_Kcoa_ms))/((1 + gly/MS_Kgly_ms + mal/MS_Kmal_ms)*(1 + aca/MS_Kaca_ms + coa/MS_Kcoa_ms)));
  SYN: akg -> $biosyn; cell*0.0341*((SYN_Vf_icd1*(icit/SYN_Kicit_icd1) - SYN_Vr_icd1*(akg/SYN_Kakg_icd1))/(1 + icit/SYN_Kicit_icd1 + akg/SYN_Kakg_icd1) + (SYN_Vf_icd2*(icit/SYN_Kicit_icd2) - SYN_Vr_icd2*(akg/SYN_Kakg_icd2))/(1 + icit/SYN_Kicit_icd2 + akg/SYN_Kakg_icd2));

  // Species initializations:
  aca = 0.5;
  oaa = 0.0003;
  coa = 0.0001;
  cit = 3.4;
  icit = 0.06;
  akg = 0.96;
  ssa = 0.03;
  suc = 2.464;
  sca = 0.04;
  fa = 0.08528;
  mal = 0.408;
  gly = 0.114;
  biosyn = 0.1;

  // Compartment initializations:
  cell = 1;

  // Variable initializations:
  CS_Vf_cs = 64.8;
  CS_Vf_cs has mmlmin;
  CS_Kaca_cs = 0.05;
  CS_Kaca_cs has mml;
  CS_Koaa_cs = 0.012;
  CS_Koaa_cs has mml;
  CS_Vr_cs = 0.648;
  CS_Vr_cs has mmlmin;
  CS_Kcoa_cs = 0.5;
  CS_Kcoa_cs has mml;
  CS_Kcit_cs = 0.12;
  CS_Kcit_cs has mml;
  ACN_Vf_acn = 31.2;
  ACN_Vf_acn has mmlmin;
  ACN_Kcit_acn = 1.7;
  ACN_Kcit_acn has mml;
  ACN_Vr_acn = 0.312;
  ACN_Vr_acn has mmlmin;
  ACN_Kicit_acn = 0.7;
  ACN_Kicit_acn has mml;
  ICD1_Vf_icd1 = 10.2;
  ICD1_Vf_icd1 has mmlmin;
  ICD1_Kicit_icd1 = 0.03;
  ICD1_Kicit_icd1 has mml;
  ICD1_Vr_icd1 = 0.102;
  ICD1_Vr_icd1 has mmlmin;
  ICD1_Kakg_icd1 = 0.3;
  ICD1_Kakg_icd1 has mml;
  ICD2_Vf_icd2 = 9.965;
  ICD2_Vf_icd2 has mmlmin;
  ICD2_Kicit_icd2 = 0.06;
  ICD2_Kicit_icd2 has mml;
  ICD2_Vr_icd2 = 0.09965;
  ICD2_Vr_icd2 has mmlmin;
  ICD2_Kakg_icd2 = 0.6;
  ICD2_Kakg_icd2 has mml;
  KDH_Vf_kdh = 57.344;
  KDH_Vf_kdh has mmlmin;
  KDH_Kakg_kdh = 0.1;
  KDH_Kakg_kdh has mml;
  KDH_Vr_kdh = 0.57344;
  KDH_Vr_kdh has mmlmin;
  KDH_Ksca_kdh = 1;
  KDH_Ksca_kdh has mml;
  KGD_Vf_kgd = 48.3;
  KGD_Vf_kgd has mmlmin;
  KGD_Kakg_kgd = 0.48;
  KGD_Kakg_kgd has mml;
  KGD_Vr_kgd = 0.483;
  KGD_Vr_kgd has mmlmin;
  KGD_Kssa_kgd = 4.8;
  KGD_Kssa_kgd has mml;
  SSADH_Vf_ssadh = 6.51;
  SSADH_Vf_ssadh has mmlmin;
  SSADH_Kssa_ssadh = 0.015;
  SSADH_Kssa_ssadh has mml;
  SSADH_Vr_ssadh = 0.0651;
  SSADH_Vr_ssadh has mmlmin;
  SSADH_Ksuc_ssadh = 0.15;
  SSADH_Ksuc_ssadh has mml;
  ScAS_Vf_scas = 1.2;
  ScAS_Vf_scas has mmlmin;
  ScAS_Ksca_scas = 0.02;
  ScAS_Ksca_scas has mml;
  ScAS_Vr_scas = 0.012;
  ScAS_Vr_scas has mmlmin;
  ScAS_Ksuc_scas = 5;
  ScAS_Ksuc_scas has mml;
  SDH_Vf_sdh = 1.02;
  SDH_Vf_sdh has mmlmin;
  SDH_Ksuc_sdh = 0.12;
  SDH_Ksuc_sdh has mml;
  SDH_Vr_sdh = 1.02;
  SDH_Vr_sdh has mmlmin;
  SDH_Kfa_sdh = 0.15;
  SDH_Kfa_sdh has mml;
  FUM_Vf_fum = 87.7;
  FUM_Vf_fum has mmlmin;
  FUM_Kfa_fum = 0.25;
  FUM_Kfa_fum has mml;
  FUM_Vr_fum = 87.7;
  FUM_Vr_fum has mmlmin;
  FUM_Kmal_fum = 2.38;
  FUM_Kmal_fum has mml;
  MDH_Vf_mdh = 184;
  MDH_Vf_mdh has mmlmin;
  MDH_Kmal_mdh = 0.833;
  MDH_Kmal_mdh has mml;
  MDH_Vr_mdh = 184;
  MDH_Vr_mdh has mmlmin;
  MDH_Koaa_mdh = 0.0443;
  MDH_Koaa_mdh has mml;
  ICL1_Vf_icl1 = 1.172;
  ICL1_Vf_icl1 has mmlmin;
  ICL1_Kicit_icl1 = 0.145;
  ICL1_Kicit_icl1 has mml;
  ICL1_Vr_icl1 = 0.01172;
  ICL1_Vr_icl1 has mmlmin;
  ICL1_Ksuc_icl1 = 0.59;
  ICL1_Ksuc_icl1 has mml;
  ICL1_Kgly_icl1 = 0.13;
  ICL1_Kgly_icl1 has mml;
  ICL2_Vf_icl2 = 0.391;
  ICL2_Vf_icl2 has mmlmin;
  ICL2_Kicit_icl2 = 1.3;
  ICL2_Kicit_icl2 has mml;
  ICL2_Vr_icl2 = 0.00391;
  ICL2_Vr_icl2 has mmlmin;
  ICL2_Ksuc_icl2 = 5.9;
  ICL2_Ksuc_icl2 has mml;
  ICL2_Kgly_icl2 = 1.3;
  ICL2_Kgly_icl2 has mml;
  MS_Vf_ms = 20;
  MS_Vf_ms has mmlmin;
  MS_Kgly_ms = 0.057;
  MS_Kgly_ms has mml;
  MS_Kaca_ms = 0.03;
  MS_Kaca_ms has mml;
  MS_Vr_ms = 0.2;
  MS_Vr_ms has mmlmin;
  MS_Kmal_ms = 1;
  MS_Kmal_ms has mml;
  MS_Kcoa_ms = 0.1;
  MS_Kcoa_ms has mml;
  SYN_Vf_icd1 = 10.2;
  SYN_Vf_icd1 has mmlmin;
  SYN_Kicit_icd1 = 0.03;
  SYN_Kicit_icd1 has mml;
  SYN_Vr_icd1 = 0.102;
  SYN_Vr_icd1 has mmlmin;
  SYN_Kakg_icd1 = 0.3;
  SYN_Kakg_icd1 has mml;
  SYN_Vf_icd2 = 9.965;
  SYN_Vf_icd2 has mmlmin;
  SYN_Kicit_icd2 = 0.06;
  SYN_Kicit_icd2 has mml;
  SYN_Vr_icd2 = 0.09965;
  SYN_Vr_icd2 has mmlmin;
  SYN_Kakg_icd2 = 0.6;
  SYN_Kakg_icd2 has mml;

  // Other declarations:
  const cell;

  // Unit definitions:
  unit time_unit = 60 second;
  unit substance = 1e-3 mole;
  unit mmlmin = 1e-3 mole / (litre * 60 second);
  unit mml = 1e-3 mole / litre;

  // Display Names:
  time_unit is "min";
  substance is "mmole";
  mmlmin is "mM_per_min";
  mml is "mM";

  // SBO terms:
  aca.sboTerm = 247
  oaa.sboTerm = 247
  coa.sboTerm = 247
  cit.sboTerm = 247
  icit.sboTerm = 247
  akg.sboTerm = 247
  ssa.sboTerm = 247
  suc.sboTerm = 247
  sca.sboTerm = 247
  fa.sboTerm = 247
  mal.sboTerm = 247
  gly.sboTerm = 247
  CS_Vf_cs.sboTerm = 350
  CS_Kaca_cs.sboTerm = 322
  CS_Koaa_cs.sboTerm = 322
  CS_Vr_cs.sboTerm = 353
  CS_Kcoa_cs.sboTerm = 323
  CS_Kcit_cs.sboTerm = 323
  ACN_Vf_acn.sboTerm = 350
  ACN_Kcit_acn.sboTerm = 322
  ACN_Vr_acn.sboTerm = 353
  ACN_Kicit_acn.sboTerm = 323
  ICD1_Vf_icd1.sboTerm = 350
  ICD1_Kicit_icd1.sboTerm = 322
  ICD1_Vr_icd1.sboTerm = 353
  ICD1_Kakg_icd1.sboTerm = 323
  ICD2_Vf_icd2.sboTerm = 350
  ICD2_Kicit_icd2.sboTerm = 322
  ICD2_Vr_icd2.sboTerm = 353
  ICD2_Kakg_icd2.sboTerm = 323
  KDH_Vf_kdh.sboTerm = 350
  KDH_Kakg_kdh.sboTerm = 322
  KDH_Vr_kdh.sboTerm = 353
  KDH_Ksca_kdh.sboTerm = 323
  KGD_Vf_kgd.sboTerm = 350
  KGD_Kakg_kgd.sboTerm = 322
  KGD_Vr_kgd.sboTerm = 353
  KGD_Kssa_kgd.sboTerm = 323
  SSADH_Vf_ssadh.sboTerm = 350
  SSADH_Kssa_ssadh.sboTerm = 322
  SSADH_Vr_ssadh.sboTerm = 353
  SSADH_Ksuc_ssadh.sboTerm = 323
  ScAS_Vf_scas.sboTerm = 350
  ScAS_Ksca_scas.sboTerm = 322
  ScAS_Vr_scas.sboTerm = 353
  ScAS_Ksuc_scas.sboTerm = 323
  SDH_Vf_sdh.sboTerm = 350
  SDH_Ksuc_sdh.sboTerm = 322
  SDH_Vr_sdh.sboTerm = 353
  SDH_Kfa_sdh.sboTerm = 323
  FUM_Vf_fum.sboTerm = 350
  FUM_Kfa_fum.sboTerm = 322
  FUM_Vr_fum.sboTerm = 353
  FUM_Kmal_fum.sboTerm = 323
  MDH_Vf_mdh.sboTerm = 350
  MDH_Kmal_mdh.sboTerm = 322
  MDH_Vr_mdh.sboTerm = 353
  MDH_Koaa_mdh.sboTerm = 323
  ICL1_Vf_icl1.sboTerm = 350
  ICL1_Kicit_icl1.sboTerm = 322
  ICL1_Vr_icl1.sboTerm = 353
  ICL1_Ksuc_icl1.sboTerm = 323
  ICL1_Kgly_icl1.sboTerm = 323
  ICL2_Vf_icl2.sboTerm = 350
  ICL2_Kicit_icl2.sboTerm = 322
  ICL2_Vr_icl2.sboTerm = 353
  ICL2_Ksuc_icl2.sboTerm = 323
  ICL2_Kgly_icl2.sboTerm = 323
  MS_Vf_ms.sboTerm = 350
  MS_Kgly_ms.sboTerm = 322
  MS_Kaca_ms.sboTerm = 322
  MS_Vr_ms.sboTerm = 353
  MS_Kmal_ms.sboTerm = 323
  MS_Kcoa_ms.sboTerm = 323
  SYN_Vf_icd1.sboTerm = 350
  SYN_Kicit_icd1.sboTerm = 322
  SYN_Vr_icd1.sboTerm = 353
  SYN_Kakg_icd1.sboTerm = 323
  SYN_Vf_icd2.sboTerm = 350
  SYN_Kicit_icd2.sboTerm = 322
  SYN_Vr_icd2.sboTerm = 353
  SYN_Kakg_icd2.sboTerm = 323

  // CV terms:
  aca hypernym "http://identifiers.org/obo.chebi/CHEBI:15351",
               "http://identifiers.org/kegg.compound/C00024"
  oaa hypernym "http://identifiers.org/obo.chebi/CHEBI:30744",
               "http://identifiers.org/kegg.compound/C00036"
  coa hypernym "http://identifiers.org/obo.chebi/CHEBI:15346",
               "http://identifiers.org/kegg.compound/C00010"
  cit hypernym "http://identifiers.org/obo.chebi/CHEBI:30769",
               "http://identifiers.org/kegg.compound/C00158"
  icit hypernym "http://identifiers.org/obo.chebi/CHEBI:30887",
                "http://identifiers.org/kegg.compound/C00311"
  akg hypernym "http://identifiers.org/obo.chebi/CHEBI:30915",
               "http://identifiers.org/kegg.compound/C00026"
  ssa hypernym "http://identifiers.org/obo.chebi/CHEBI:16265",
               "http://identifiers.org/kegg.compound/C00232"
  suc hypernym "http://identifiers.org/obo.chebi/CHEBI:15741",
               "http://identifiers.org/kegg.compound/C00042"
  sca hypernym "http://identifiers.org/obo.chebi/CHEBI:15380",
               "http://identifiers.org/kegg.compound/C00091"
  fa hypernym "http://identifiers.org/obo.chebi/CHEBI:18012",
              "http://identifiers.org/kegg.compound/C00122"
  mal hypernym "http://identifiers.org/obo.chebi/CHEBI:6650",
               "http://identifiers.org/kegg.compound/C00711"
  gly hypernym "http://identifiers.org/obo.chebi/CHEBI:16891",
               "http://identifiers.org/kegg.compound/C00048"
  CS hypernym "http://identifiers.org/kegg.reaction/R00351"
  ACN hypernym "http://identifiers.org/kegg.reaction/R01324"
  ICD1 hypernym "http://identifiers.org/kegg.reaction/R00709"
  ICD2 hypernym "http://identifiers.org/kegg.reaction/R00709"
  KDH hypernym "http://identifiers.org/kegg.reaction/R08549"
  KGD hypernym "http://identifiers.org/kegg.reaction/R00272"
  SSADH hypernym "http://identifiers.org/kegg.reaction/R00714"
  ScAS hypernym "http://identifiers.org/kegg.reaction/R00407"
  SDH hypernym "http://identifiers.org/kegg.reaction/R00402"
  FUM hypernym "http://identifiers.org/kegg.reaction/R01082"
  MDH hypernym "http://identifiers.org/kegg.reaction/R00342"
  ICL1 hypernym "http://identifiers.org/kegg.reaction/R00479"
  ICL2 hypernym "http://identifiers.org/kegg.reaction/R00479"
  MS hypernym "http://identifiers.org/kegg.reaction/R00472"
  SYN hypernym "http://identifiers.org/obo.go/GO:0006103"
end

Singh2006_TCA_mtu_model1 is "Singh2006_TCA_mtu_model1"

Singh2006_TCA_mtu_model1 model_entity_is "http://identifiers.org/biomodels.db/MODEL8584292730"
Singh2006_TCA_mtu_model1 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000219"
Singh2006_TCA_mtu_model1 description "http://identifiers.org/pubmed/16887020"
Singh2006_TCA_mtu_model1 taxon "http://identifiers.org/taxonomy/1773"
Singh2006_TCA_mtu_model1 homolog "http://identifiers.org/reactome/REACT_1785"
Singh2006_TCA_mtu_model1 version "http://identifiers.org/obo.go/GO:0006097",
                                 "http://identifiers.org/obo.go/GO:0006099"
Singh2006_TCA_mtu_model1 hypernym "http://identifiers.org/kegg.pathway/ko00020"
