// Created by libAntimony v2.13.0
model *MODEL8389825246()

  // Compartments and Species:
  compartment cell;
  species $OCT4_Gene in cell, $NANOG_Gene in cell, $SOX2_Gene in cell, $GATA6_Gene in cell;
  species $CDX2_Gene in cell, $GCNF_Gene in cell, $targetGene in cell, $degradation in cell;
  species $p53 in cell, $A in cell, OCT4 in cell, SOX2 in cell, NANOG in cell;
  species GATA6 in cell, CDX2 in cell, GCNF in cell, OCT4_SOX2 in cell, Protein in cell;

  // Reactions:
  R1: $OCT4_Gene => OCT4; (a0 + a1*A + a2*OCT4*SOX2 + a3*OCT4*SOX2*NANOG)/(1 + b0*A + b1*OCT4 + b2*OCT4*SOX2 + b3*OCT4*SOX2*NANOG + b4*CDX2*OCT4 + b5*GCNF);
  R2: OCT4 => $degradation; gamma1*OCT4;
  R3: $SOX2_Gene => SOX2; (c0 + c1*OCT4*SOX2 + c2*OCT4*SOX2*NANOG)/(1 + d0*OCT4 + d1*OCT4*SOX2 + d2*OCT4*SOX2*NANOG);
  R4: SOX2 => $degradation; gamma2*SOX2;
  R5: $NANOG_Gene => NANOG; (a1*OCT4_SOX2 + a2*OCT4_SOX2*NANOG)/(1 + b1*OCT4_SOX2 + b2*OCT4_SOX2*NANOG + b3*OCT4_SOX2*GATA6);
  R6: NANOG => $degradation; gamman*NANOG;
  R7: $CDX2_Gene => CDX2; (g0 + g1*CDX2)/(1 + h0*CDX2 + h1*CDX2*OCT4);
  R8: CDX2 => $degradation; gamma4*CDX2;
  R9: $GCNF_Gene => GCNF; (i0 + i1*CDX2 + i2*GATA6)/(1 + j0*CDX2 + j1*GATA6);
  R10: GCNF => $degradation; gamma5*GCNF;
  R11: $GATA6_Gene => GATA6; (c1*OCT4_SOX2 + c2*GATA6)/(1 + d1*OCT4_SOX2 + d2*GATA6 + d3*NANOG);
  R12: GATA6 => $degradation; gammag*GATA6;

  // Species initializations:
  OCT4_Gene = 0;
  NANOG_Gene = 0;
  SOX2_Gene = 0;
  GATA6_Gene = 0;
  CDX2_Gene = 0;
  GCNF_Gene = 0;
  targetGene = 0.01;
  degradation = 0;
  p53 = 0;
  A = 10;
  OCT4 = 0.01;
  SOX2 = 0.01;
  NANOG = 0.01;
  GATA6 = 0.01;
  CDX2 = 0.01;
  GCNF = 0.01;
  OCT4_SOX2 = 0.1;
  Protein = 0;

  // Compartment initializations:
  cell = 1;

  // Variable initializations:
  a0 = 0.001;
  a1 = 0.02;
  a2 = 0.0125;
  a3 = 0.025;
  b0 = 1;
  b1 = 0.02;
  b2 = 0.0125;
  b3 = 0.03;
  b4 = 10;
  b5 = 10;
  gamma1 = 0.1;
  c0 = 0.001;
  c1 = 0.05;
  c2 = 0.0125;
  d0 = 0.001;
  d1 = 0.05;
  d2 = 0.0125;
  d3 = 0.05;
  gamma2 = 0.1;
  e0 = 0.001;
  e1 = 0.1;
  e2 = 0.1;
  f0 = 0.001;
  f1 = 0.1;
  f2 = 0.1;
  f3 = 10;
  gamma3 = 0.1;
  g0 = 0.001;
  g1 = 2;
  h0 = 2;
  h1 = 5;
  gamma4 = 0.1;
  i0 = 0.001;
  i1 = 0.1;
  i2 = 0.1;
  j0 = 0.1;
  j1 = 0.1;
  gamma5 = 0.1;
  p0 = 0.1;
  p1 = 1;
  p2 = 0.00025;
  q0 = 1;
  q1 = 0.00025;
  q2 = 15;
  gammag = 0.01;
  gamman = 0.01;

  // Other declarations:
  const cell, a0, a1, a2, a3, b0, b1, b2, b3, b4, b5, gamma1, c0, c1, c2;
  const d0, d1, d2, d3, gamma2, e0, e1, e2, f0, f1, f2, f3, gamma3, g0, g1;
  const h0, h1, gamma4, i0, i1, i2, j0, j1, gamma5, p0, p1, p2, q0, q1, q2;
  const gammag, gamman;

  // CV terms:
  OCT4_Gene hypernym "http://identifiers.org/ensembl/ENSG00000204531"
  OCT4_Gene encodement "http://identifiers.org/uniprot/Q01860"
  NANOG_Gene hypernym "http://identifiers.org/ensembl/ENSG00000176654"
  NANOG_Gene encodement "http://identifiers.org/uniprot/Q8N7R0"
  SOX2_Gene hypernym "http://identifiers.org/ensembl/ENSG00000165661"
  SOX2_Gene encodement "http://identifiers.org/uniprot/Q6ZRP7"
  GATA6_Gene hypernym "http://identifiers.org/ensembl/ENSG00000141448"
  GATA6_Gene encodement "http://identifiers.org/uniprot/Q92908"
  CDX2_Gene hypernym "http://identifiers.org/ensembl/ENSG00000165556"
  CDX2_Gene encodement "http://identifiers.org/uniprot/Q99626"
  GCNF_Gene hypernym "http://identifiers.org/ensembl/ENSG00000148200"
  GCNF_Gene encodement "http://identifiers.org/uniprot/Q15406"
  p53 hypernym "http://identifiers.org/uniprot/P04637"
  A hypernym "http://identifiers.org/obo.go/GO:0042813"
  OCT4 hypernym "http://identifiers.org/uniprot/Q01860"
  SOX2 hypernym "http://identifiers.org/uniprot/Q6ZRP7"
  NANOG hypernym "http://identifiers.org/uniprot/Q8N7R0"
  GATA6 hypernym "http://identifiers.org/uniprot/Q92908"
  CDX2 hypernym "http://identifiers.org/uniprot/Q99626"
  GCNF hypernym "http://identifiers.org/uniprot/Q15406"
  OCT4_SOX2 part "http://identifiers.org/uniprot/Q6ZRP7"
  OCT4_SOX2 part "http://identifiers.org/uniprot/Q01860"
  R1 hypernym "http://identifiers.org/obo.go/GO:0010467"
  R2 hypernym "http://identifiers.org/obo.go/GO:0030163"
  R3 hypernym "http://identifiers.org/obo.go/GO:0010467"
  R4 hypernym "http://identifiers.org/obo.go/GO:0030163"
  R5 hypernym "http://identifiers.org/obo.go/GO:0010467"
  R6 hypernym "http://identifiers.org/obo.go/GO:0030163"
  R7 hypernym "http://identifiers.org/obo.go/GO:0010467"
  R8 hypernym "http://identifiers.org/obo.go/GO:0030163"
  R9 hypernym "http://identifiers.org/obo.go/GO:0010467"
  R10 hypernym "http://identifiers.org/obo.go/GO:0030163"
  R11 hypernym "http://identifiers.org/obo.go/GO:0010467"
  R12 hypernym "http://identifiers.org/obo.go/GO:0030163"
end

MODEL8389825246 is "Chickarmane2008 - Stem cell lineage - NANOG GATA-6 switch"

MODEL8389825246 model_entity_is "http://identifiers.org/biomodels.db/MODEL8389825246"
MODEL8389825246 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000210"
MODEL8389825246 description "http://identifiers.org/pubmed/18941526"
MODEL8389825246 origin "http://identifiers.org/biomodels.db/BIOMD0000000204",
                       "http://identifiers.org/biomodels.db/BIOMD0000000203"
MODEL8389825246 hypernym "http://identifiers.org/obo.go/GO:0048863",
                         "http://identifiers.org/obo.go/GO:0001830",
                         "http://identifiers.org/obo.go/GO:0042663"
MODEL8389825246 taxon "http://identifiers.org/taxonomy/9606"
