// Created by libAntimony v2.13.0
model *RanGTP_gradient()

  // Compartments and Species:
  compartment nucleus, cytoplasm;
  species RanGDP_nuc in nucleus, RCC1_RanGDP in nucleus, $GDP in nucleus;
  species RCC1 in nucleus, RCC1_RanGTP in nucleus, RCC1_Ran in nucleus, $GTP in nucleus;
  species RanGTP_nuc in nucleus, RanGAP in cytoplasm, RanBP1 in cytoplasm;
  species RanGTP_cy in cytoplasm, RanGTP_RanBP1 in cytoplasm, RanGDP_cy in cytoplasm;

  // Reactions:
  RCC1_binding: RanGDP_nuc + RCC1 -> RCC1_RanGDP; nucleus*(RCC1_binding_r1*RanGDP_nuc*RCC1 - RCC1_binding_r8*RCC1_RanGDP);
  GDP_dissociation: RCC1_RanGDP -> RCC1_Ran + $GDP; nucleus*(GDP_dissociation_r2*RCC1_RanGDP - GDP_dissociation_r7*RCC1_Ran*GDP);
  GTP_binding: RCC1_Ran + $GTP -> RCC1_RanGTP; nucleus*(GTP_binding_r3*RCC1_Ran*GTP - GTP_binding_r6*RCC1_RanGTP);
  RanGTP_release: RCC1_RanGTP -> RanGTP_nuc + RCC1; nucleus*(RanGTP_release_r4*RCC1_RanGTP - RanGTP_release_r5*RanGTP_nuc*RCC1);
  Cytoplasmic_transfer: RanGTP_nuc -> RanGTP_cy; Cytoplasmic_transfer_kpermRanGTP*nucleus*(RanGTP_nuc - RanGTP_cy);
  Nucleoplasmic_transfer: RanGDP_nuc -> RanGDP_cy; Nucleoplasmic_transfer_kpermRanGDP*nucleus*(RanGDP_nuc - RanGDP_cy);
  RanGTP_binding: RanGTP_cy + RanBP1 -> RanGTP_RanBP1; (RanGTP_binding_kon*RanGTP_cy*RanBP1 - RanGTP_binding_koff*RanGTP_RanBP1)*cytoplasm;
  RanBP1_RanGDP: RanGTP_RanBP1 -> RanGDP_cy + RanBP1; cytoplasm*RanBP1_RanGDP_kcat*RanGTP_RanBP1*RanGAP/(RanGTP_RanBP1 + RanBP1_RanGDP_Km);
  RanGAP_RanGDP: RanGTP_cy -> RanGDP_cy; cytoplasm*RanGAP_RanGDP_kcat_GAP*RanGTP_cy*RanGAP/(RanGAP_RanGDP_Km_GAP + RanGTP_cy);

  // Species initializations:
  RanGDP_nuc = 0;
  RCC1_RanGDP = 0;
  GDP = 1.6;
  RCC1 = 0.7;
  RCC1_RanGTP = 0;
  RCC1_Ran = 0;
  GTP = 500;
  RanGTP_nuc = 0;
  RanGAP = 0.7;
  RanBP1 = 2;
  RanGTP_cy = 0;
  RanGTP_RanBP1 = 0;
  RanGDP_cy = 5;

  // Compartment initializations:
  nucleus = 1.2e-11;
  cytoplasm = 1.8e-11;

  // Variable initializations:
  RCC1_binding_r1 = 74;
  RCC1_binding_r1 has pmicroMpsec;
  RCC1_binding_r8 = 55;
  RCC1_binding_r8 has psec;
  GDP_dissociation_r2 = 21;
  GDP_dissociation_r2 has psec;
  GDP_dissociation_r7 = 11;
  GDP_dissociation_r7 has pmicroMpsec;
  GTP_binding_r3 = 0.6;
  GTP_binding_r3 has pmicroMpsec;
  GTP_binding_r6 = 19;
  GTP_binding_r6 has psec;
  RanGTP_release_r4 = 55;
  RanGTP_release_r4 has psec;
  RanGTP_release_r5 = 100;
  RanGTP_release_r5 has pmicroMpsec;
  Cytoplasmic_transfer_kpermRanGTP = 0.03;
  Cytoplasmic_transfer_kpermRanGTP has psec;
  Nucleoplasmic_transfer_kpermRanGDP = 0.12;
  Nucleoplasmic_transfer_kpermRanGDP has psec;
  RanGTP_binding_kon = 0.3;
  RanGTP_binding_kon has pmicroMpsec;
  RanGTP_binding_koff = 0.0004;
  RanGTP_binding_koff has psec;
  RanBP1_RanGDP_kcat = 10.8;
  RanBP1_RanGDP_kcat has psec;
  RanBP1_RanGDP_Km = 0.1;
  RanBP1_RanGDP_Km has microM;
  RanGAP_RanGDP_kcat_GAP = 10.6;
  RanGAP_RanGDP_kcat_GAP has psec;
  RanGAP_RanGDP_Km_GAP = 0.7;
  RanGAP_RanGDP_Km_GAP has microM;

  // Other declarations:
  const nucleus, cytoplasm;

  // Unit definitions:
  unit substance = 1e-6 mole;
  unit microMpsec = 1e-6 mole / (second * litre);
  unit pmicroMpsec = litre / (1e-6 mole * second);
  unit psec = 1 / second;
  unit microM = 1e-6 mole / litre;

  // CV terms:
  nucleus identity "http://identifiers.org/go/GO:0005634"
  cytoplasm identity "http://identifiers.org/go/GO:0005737"
  RanGDP_nuc part "http://identifiers.org/uniprot/P62826",
                  "http://identifiers.org/kegg.compound/C00035"
  RCC1_RanGDP part "http://identifiers.org/chebi/CHEBI:17552",
                   "http://identifiers.org/uniprot/P18754",
                   "http://identifiers.org/uniprot/P62826",
                   "http://identifiers.org/kegg.compound/C00035"
  GDP identity "http://identifiers.org/chebi/CHEBI:17552",
               "http://identifiers.org/kegg.compound/C00035"
  RCC1 encoder "http://identifiers.org/ensembl/ENSG00000180198"
  RCC1 identity "http://identifiers.org/uniprot/P18754"
  RCC1_RanGTP part "http://identifiers.org/chebi/CHEBI:15996",
                   "http://identifiers.org/uniprot/P62826",
                   "http://identifiers.org/uniprot/P18754",
                   "http://identifiers.org/kegg.compound/C00044"
  RCC1_Ran part "http://identifiers.org/uniprot/P18754",
                "http://identifiers.org/uniprot/P62826"
  GTP identity "http://identifiers.org/chebi/CHEBI:15996",
               "http://identifiers.org/kegg.compound/C00044"
  RanGTP_nuc part "http://identifiers.org/uniprot/P62826",
                  "http://identifiers.org/kegg.compound/C00044"
  RanGAP hypernym "http://identifiers.org/interpro/IPR000331"
  RanGAP identity "http://identifiers.org/uniprot/P46060"
  RanBP1 hypernym "http://identifiers.org/interpro/IPR000156"
  RanBP1 identity "http://identifiers.org/uniprot/P43487"
  RanGTP_cy part "http://identifiers.org/uniprot/P62826",
                 "http://identifiers.org/kegg.compound/C00044"
  RanGTP_RanBP1 part "http://identifiers.org/uniprot/P62826",
                     "http://identifiers.org/uniprot/P43487",
                     "http://identifiers.org/kegg.compound/C00044"
  RanGDP_cy part "http://identifiers.org/uniprot/P62826",
                 "http://identifiers.org/kegg.compound/C00035"
  RCC1_binding hypernym "http://identifiers.org/go/GO:0006461"
  GDP_dissociation hypernym "http://identifiers.org/go/GO:0005087"
  GTP_binding hypernym "http://identifiers.org/go/GO:0005525"
  RanGTP_release hypernym "http://identifiers.org/go/GO:0043241"
  Cytoplasmic_transfer hypernym "http://identifiers.org/go/GO:0006913"
  Nucleoplasmic_transfer hypernym "http://identifiers.org/go/GO:0006913"
  RanGTP_binding hypernym "http://identifiers.org/go/GO:0006461"
  RanBP1_RanGDP hypernym "http://identifiers.org/go/GO:0043241"
  RanGAP_RanGDP hypernym "http://identifiers.org/go/GO:0032860"
end

RanGTP_gradient is "Görlich2003_RanGTP_gradient"

RanGTP_gradient model_entity_is "http://identifiers.org/biomodels.db/MODEL4969417017"
RanGTP_gradient model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000192"
RanGTP_gradient description "http://identifiers.org/pubmed/12606574"
RanGTP_gradient taxon "http://identifiers.org/taxonomy/9606"
RanGTP_gradient hypernym "http://identifiers.org/go/GO:0008536"
RanGTP_gradient parthood "http://identifiers.org/reactome/REACT_9507"
