// Created by libAntimony v2.13.0
model *Obeyesekere1999_CellCycle()

  // Compartments and Species:
  compartment cell_1;
  species D_1 in cell_1, E_1 in cell_1, RS_1 in cell_1, R_1 in cell_1, X_1 in cell_1;
  species $E2F_1 in cell_1, $RP_1 in cell_1;

  // Assignment Rules:
  E2F_1 := theta_1 - RS_1;
  RP_1 := RT_1 - RS_1 - R_1;
  unpho_RB := R_1 + RS_1;

  // Reactions:
  _1:  => D_1; aD_1*(k_1*GF_1/(1 + k_1*GF_1));
  cyclinCDK4degradation_1: D_1 => ; dD_1*E_1*D_1;
  cyclin_1:  => E_1; aE_1*(1 + af_1*E2F_1);
  cycECDK2degradation_1: E_1 => ; dE_1*X_1*E_1;
  pRBpdephosphorylation_1:  => R_1; pX_1*RP_1*X_1/(qX_1 + RP_1 + X_1);
  pRBE2Fcomplexassociation_1: R_1 => RS_1; pS_1*E2F_1*R_1;
  pRBE2FcomplexdeassociationviacycDCDK4_1: RS_1 => ; pD_1*RS_1*D_1/(qD_1 + RS_1 + D_1);
  _7: RS_1 => ; pE_1*RS_1*E_1/(qE_1 + RS_1 + E_1);
  cycleprogression_1:  => X_1; aX_1*E_1 + f_1*E2F_1 + g_1*X_1^2*E_1;
  cyclebreak_1: X_1 => ; dX_1*X_1;

  // Species initializations:
  D_1 = 0.1/cell_1;
  E_1 = 0.6/cell_1;
  RS_1 = 1/cell_1;
  R_1 = 0.5/cell_1;
  X_1 = 0.7/cell_1;

  // Compartment initializations:
  cell_1 = 1;

  // Variable initializations:
  theta_1 = 1.5;
  RT_1 = 2.5;
  aD_1 = 0.4;
  k_1 = 0.05;
  GF_1 = 6.3;
  dD_1 = 0.4;
  aE_1 = 0.16;
  af_1 = 0.9;
  dE_1 = 0.2;
  pX_1 = 0.48;
  pS_1 = 0.6;
  pD_1 = 0.48;
  qD_1 = 0.6;
  pE_1 = 0.096;
  qE_1 = 0.6;
  aX_1 = 0.08;
  f_1 = 0.2;
  g_1 = 0.528;
  dX_1 = 1.04;
  qX_1 = 0.8;

  // Other declarations:
  var unpho_RB;
  const cell_1, theta_1, RT_1, aD_1, k_1, GF_1, dD_1, aE_1, af_1, dE_1, pX_1;
  const pS_1, pD_1, qD_1, pE_1, qE_1, aX_1, f_1, g_1, dX_1, qX_1;

  // Display Names:
  cell_1 is "cell";
  D_1 is "D";
  E_1 is "E";
  RS_1 is "RS";
  R_1 is "R";
  X_1 is "X";
  E2F_1 is "E2F";
  theta_1 is "theta";
  RP_1 is "RP";
  RT_1 is "RT";
  aD_1 is "aD";
  k_1 is "k";
  GF_1 is "GF";
  dD_1 is "dD";
  aE_1 is "aE";
  af_1 is "af";
  dE_1 is "dE";
  pX_1 is "pX";
  pS_1 is "pS";
  pD_1 is "pD";
  qD_1 is "qD";
  pE_1 is "pE";
  qE_1 is "qE";
  aX_1 is "aX";
  f_1 is "f";
  g_1 is "g";
  dX_1 is "dX";
  qX_1 is "qX";
  _1 is "cycD/CDK4 synthesis";
  cyclinCDK4degradation_1 is "cycD/CDK4 degradation";
  cyclin_1 is "cycE/CDK2 synthesis";
  cycECDK2degradation_1 is "cycE/CDK2 degradation";
  pRBpdephosphorylation_1 is "pRB-p dephosphorilation";
  pRBE2Fcomplexassociation_1 is "pRB/E2F complex association";
  pRBE2FcomplexdeassociationviacycDCDK4_1 is "pRB/E2F complex deassociation via cycD/CDK4";
  _7 is "pRB/E2F complex deassociation via cycE/CDK2";
  cycleprogression_1 is "cycle progression";
  cyclebreak_1 is "cycle break";

  // CV terms:
  cell_1 identity "http://identifiers.org/go/GO:0005623"
  D_1 hypernym "http://identifiers.org/uniprot/P24385"
  E_1 hypernym "http://identifiers.org/uniprot/P24864"
  RS_1 part "http://identifiers.org/uniprot/Q01094",
            "http://identifiers.org/uniprot/P06400"
  R_1 hypernym "http://identifiers.org/uniprot/P06400"
  E2F_1 hypernym "http://identifiers.org/uniprot/Q01094"
  RP_1 hypernym "http://identifiers.org/uniprot/P06400"
  _1 hypernym "http://identifiers.org/go/GO:0006412"
  cyclinCDK4degradation_1 hypernym "http://identifiers.org/go/GO:0008054"
  cyclin_1 hypernym "http://identifiers.org/go/GO:0006412"
  cycECDK2degradation_1 hypernym "http://identifiers.org/go/GO:0008054"
  pRBpdephosphorylation_1 hypernym "http://identifiers.org/go/GO:0016311"
  pRBE2Fcomplexassociation_1 hypernym "http://identifiers.org/go/GO:0006461"
  pRBE2FcomplexdeassociationviacycDCDK4_1 hypernym "http://identifiers.org/go/GO:0043624"
  _7 hypernym "http://identifiers.org/go/GO:0043624"
  cycleprogression_1 hypernym "http://identifiers.org/go/GO:0051726"
  cyclebreak_1 hypernym "http://identifiers.org/go/GO:0051726"
end

Obeyesekere1999_CellCycle is "Obeyesekere1999_CellCycle"

Obeyesekere1999_CellCycle model_entity_is "http://identifiers.org/biomodels.db/MODEL3896909694"
Obeyesekere1999_CellCycle model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000168"
Obeyesekere1999_CellCycle description "http://identifiers.org/pubmed/17886749"
Obeyesekere1999_CellCycle origin "http://identifiers.org/pubmed/9375029"
Obeyesekere1999_CellCycle parthood "http://identifiers.org/kegg.pathway/hsa04110"
Obeyesekere1999_CellCycle hypernym "http://identifiers.org/go/GO:0000278"
Obeyesekere1999_CellCycle taxon "http://identifiers.org/taxonomy/2759"
