// Created by libAntimony v2.13.0
model *Clarke2006_Smad_signalling()

  // Compartments and Species:
  compartment cytoplasm, nucleus;
  substanceOnly species receptor in cytoplasm, R_smad_cyt in cytoplasm, R_smad_P_cyt in cytoplasm;
  substanceOnly species smad4_cyt in cytoplasm, R_smad_P_smad4_cyt in cytoplasm;
  substanceOnly species R_smad_P_smad4_nuc in nucleus, R_smad_nuc in nucleus;
  substanceOnly species R_smad_P_nuc in nucleus, smad4_nuc in nucleus, Pi in nucleus;

  // Assignment Rules:
  sum_R_smad_cyt := R_smad_cyt + R_smad_P_cyt + R_smad_P_smad4_cyt;
  sum_R_smad_nuc := R_smad_nuc + R_smad_P_nuc + R_smad_P_smad4_nuc;
  sum_smad4_cyt := smad4_cyt + R_smad_P_smad4_cyt;
  sum_smad4_nuc := smad4_nuc + R_smad_P_smad4_nuc;

  // Reactions:
  reaction_1: R_smad_cyt => R_smad_P_cyt; reaction_1_KCAT*receptor*R_smad_cyt/(reaction_1_K1 + R_smad_cyt);
  reaction_5: R_smad_nuc -> R_smad_cyt; reaction_5_k5nc*R_smad_nuc - reaction_5_k5cn*R_smad_cyt;
  reaction_4: smad4_nuc -> smad4_cyt; reaction_4_k4nc*smad4_nuc - reaction_4_k4cn*smad4_cyt;
  reaction_2: R_smad_P_cyt + smad4_cyt -> R_smad_P_smad4_cyt; reaction_2_k2a*R_smad_P_cyt*smad4_cyt - reaction_2_k2d*R_smad_P_smad4_cyt;
  reaction_3: R_smad_P_smad4_cyt => R_smad_P_smad4_nuc; reaction_3_k3*R_smad_P_smad4_cyt;
  reaction_6: R_smad_P_smad4_nuc -> smad4_nuc + R_smad_P_nuc; reaction_6_k6d*R_smad_P_smad4_nuc - reaction_6_k6a*smad4_nuc*R_smad_P_nuc;
  reaction_7: R_smad_P_nuc => R_smad_nuc + Pi; reaction_7_Vmax7*R_smad_P_nuc/(reaction_7_K7 + R_smad_P_nuc);
  reaction_0: receptor => ; 100*exp(-time/90);

  // Species initializations:
  receptor = 10000/cytoplasm;
  R_smad_cyt = 162000/cytoplasm;
  R_smad_P_cyt = 0;
  smad4_cyt = 120000/cytoplasm;
  R_smad_P_smad4_cyt = 0;
  R_smad_P_smad4_nuc = 0;
  R_smad_nuc = 18000/nucleus;
  R_smad_P_nuc = 0;
  smad4_nuc = 30000/nucleus;
  Pi = 0;

  // Compartment initializations:
  cytoplasm = 1;
  nucleus = 1;

  // Variable initializations:
  reaction_1_KCAT = 3.51;
  reaction_1_KCAT has min_inv;
  reaction_1_K1 = 289000;
  reaction_1_K1 has substance;
  reaction_5_k5nc = 5.63;
  reaction_5_k5nc has min_inv;
  reaction_5_k5cn = 0.563;
  reaction_5_k5cn has min_inv;
  reaction_4_k4nc = 0.783;
  reaction_4_k4nc has min_inv;
  reaction_4_k4cn = 0.00497;
  reaction_4_k4cn has min_inv;
  reaction_2_k2a = 6.5e-05;
  reaction_2_k2a has per_item_min;
  reaction_2_k2d = 0.0399;
  reaction_2_k2d has min_inv;
  reaction_3_k3 = 16.6;
  reaction_3_k3 has min_inv;
  reaction_6_k6d = 0.0492;
  reaction_6_k6d has min_inv;
  reaction_6_k6a = 0.000144;
  reaction_6_k6a has per_item_min;
  reaction_7_Vmax7 = 17100;
  reaction_7_Vmax7 has items_per_min;
  reaction_7_K7 = 8950;
  reaction_7_K7 has substance;

  // Other declarations:
  var sum_R_smad_cyt, sum_R_smad_nuc, sum_smad4_cyt, sum_smad4_nuc;
  const cytoplasm, nucleus;

  // Unit definitions:
  unit time_unit = 60 second;
  unit substance = item;
  unit min_inv = 1 / 60 second;
  unit items_per_min = item / 60 second;
  unit per_item_min = 1 / (item * 60 second);

  // Display Names:
  time_unit is "minutes";
  items_per_min is "items per min";
  per_item_min is "per item per min";
  receptor is "receptors";
  R_smad_cyt is "R-Smad_cyt";
  R_smad_P_cyt is "R-Smad-P_cyt";
  smad4_cyt is "Smad4_cyt";
  R_smad_P_smad4_cyt is "R-Smad-P-Smad4_cyt";
  R_smad_P_smad4_nuc is "R-Smad-P-Smad4_nuc";
  R_smad_nuc is "R-Smad_nuc";
  R_smad_P_nuc is "R-Smad-P_nuc";
  smad4_nuc is "Smad4_nuc";
  sum_smad4_cyt is "sum_Smad4_cyt";
  sum_smad4_nuc is "sum_Smad4_nuc";
  reaction_1 is "Phosphorylation";
  reaction_5 is "R-Smad translocation";
  reaction_4 is "Smad4 translocation";
  reaction_2 is "Complex formation";
  reaction_3 is "Complex translocation";
  reaction_6 is "Complex in nucleus";
  reaction_7 is "Dephosphorylation";
  reaction_0 is "Receptor degradation";

  // CV terms:
  cytoplasm identity "http://identifiers.org/obo.go/GO:0005737"
  nucleus identity "http://identifiers.org/obo.go/GO:0005634"
  receptor part "http://identifiers.org/uniprot/P36897",
                "http://identifiers.org/uniprot/P37173"
  R_smad_cyt homolog "http://identifiers.org/uniprot/Q15796"
  R_smad_P_cyt homolog "http://identifiers.org/uniprot/Q15796"
  smad4_cyt homolog "http://identifiers.org/uniprot/Q13485"
  R_smad_P_smad4_cyt part "http://identifiers.org/uniprot/Q13485",
                          "http://identifiers.org/uniprot/Q15796"
  R_smad_P_smad4_nuc part "http://identifiers.org/uniprot/Q15796",
                          "http://identifiers.org/uniprot/Q13485"
  R_smad_nuc homolog "http://identifiers.org/uniprot/Q15796"
  R_smad_P_nuc homolog "http://identifiers.org/uniprot/Q15796"
  smad4_nuc homolog "http://identifiers.org/uniprot/Q13485"
  Pi identity "http://identifiers.org/obo.chebi/CHEBI:18367",
              "http://identifiers.org/kegg.compound/C00009"
  reaction_1 identity "http://identifiers.org/ec-code/2.7.11.30",
                      "http://identifiers.org/obo.go/GO:0030618",
                      "http://identifiers.org/obo.go/GO:0004674"
  reaction_5 identity "http://identifiers.org/obo.go/GO:0007184"
  reaction_4 identity "http://identifiers.org/obo.go/GO:0006611"
  reaction_2 identity "http://identifiers.org/obo.go/GO:0030616",
                      "http://identifiers.org/obo.go/GO:0007183"
  reaction_3 identity "http://identifiers.org/obo.go/GO:0007184"
  reaction_6 identity "http://identifiers.org/obo.go/GO:0043624"
  reaction_7 identity "http://identifiers.org/obo.go/GO:0006470"
  reaction_0 identity "http://identifiers.org/obo.go/GO:0032801"
end

Clarke2006_Smad_signalling is "Clarke2006_Smad_signalling"

Clarke2006_Smad_signalling model_entity_is "http://identifiers.org/biomodels.db/MODEL4024559990"
Clarke2006_Smad_signalling model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000112"
Clarke2006_Smad_signalling description "http://identifiers.org/pubmed/17186703"
Clarke2006_Smad_signalling taxon "http://identifiers.org/taxonomy/452646"
Clarke2006_Smad_signalling parthood "http://identifiers.org/kegg.pathway/hsa04350"
Clarke2006_Smad_signalling identity "http://identifiers.org/obo.go/GO:0007179"
