// Created by libAntimony v2.13.0
model *Legewie2006_apoptosis_NC()

  // Compartments and Species:
  compartment cytosol;
  species A in cytosol, C9 in cytosol, C9X in cytosol, X in cytosol, AC9X in cytosol;
  species AC9 in cytosol, C3 in cytosol, C3_star in cytosol, C3_starX in cytosol;
  species C9_starX in cytosol, C9_star in cytosol, AC9_star in cytosol, AC9_starX in cytosol;
  species C9X_C3_star in cytosol, AC9X_C3_star in cytosol, C9_starX_C3_star in cytosol;
  species AC9_starX_C3_star in cytosol;

  // Reactions:
  v1: A + C9 -> AC9; cytosol*(k1*A*C9 - kb1*AC9);
  v2: C3 + C9 => C3_star + C9; cytosol*k2*C3*C9;
  v3: C3 + AC9 => C3_star + AC9; cytosol*k3*C3*AC9;
  v9: C9 + X -> C9X; cytosol*(k9*C9*X - k9b*C9X);
  v10: AC9 + X -> AC9X; cytosol*(k10*AC9*X - k10b*AC9X);
  v13: C9X + A -> AC9X; cytosol*(k13*C9X*A - k13b*AC9X);
  v15: C3_star + X -> C3_starX; cytosol*(k15*C3_star*X - k15b*C3_starX);
  v4: C9 + C3_star => C9_star + C3_star; cytosol*k4*C9*C3_star;
  v5: AC9 + C3_star => AC9_star + C3_star; cytosol*k5*AC9*C3_star;
  v8: C9_star + A -> AC9_star; cytosol*(k8*C9_star*A - k8b*AC9_star);
  v11: C9_star + X -> C9_starX; cytosol*(k11*C9_star*X - k11b*C9_starX);
  v12: AC9_star + X -> AC9_starX; cytosol*(k12*AC9_star*X - k12b*AC9_starX);
  v14: C9_starX + A -> AC9_starX; cytosol*(k14*C9_starX*A - k14b*AC9_starX);
  v6: C3 + C9_star => C3_star + C9_star; cytosol*k6*C3*C9_star;
  v7: C3 + AC9_star => C3_star + AC9_star; cytosol*k7*C3*AC9_star;
  v16:  => A; cytosol*(k16prod - k16*A);
  v17:  => C9; cytosol*(k17prod - k17*C9);
  v18:  => X; cytosol*(k18prod - k18*X);
  v19: C9X => ; cytosol*k19*C9X;
  v20: AC9X => ; cytosol*k20*AC9X;
  v21: AC9 => ; cytosol*k21*AC9;
  v22:  => C3; cytosol*(k22prod - k22*C3);
  v23: C3_star => ; cytosol*k23*C3_star;
  v24: C3_starX => ; cytosol*k24*C3_starX;
  v25: C9_starX => ; cytosol*k25*C9_starX;
  v26: C9_star => ; cytosol*k26*C9_star;
  v27: AC9_star => ; cytosol*k27*AC9_star;
  v28: AC9_starX => ; cytosol*k28*AC9_starX;
  v29: C9X_C3_star => ; cytosol*k29*C9X_C3_star;
  v30: AC9_starX_C3_star => ; cytosol*k30*AC9_starX_C3_star;
  v31: C9_starX_C3_star => ; cytosol*k31*C9_starX_C3_star;
  v32: AC9_starX_C3_star => ; cytosol*k32*AC9_starX_C3_star;
  v33: C3_star + C9X -> C9X_C3_star; cytosol*(a*k15*C3_star*C9X - d*k15b*C9X_C3_star);
  v34: C3_star + AC9X -> AC9X_C3_star; cytosol*(a*k15*C3_star*AC9X - d*k15b*AC9X_C3_star);
  v35: C3_star + C9_starX -> C9_starX_C3_star; cytosol*(a*k15*C3_star*C9_starX - d*k15b*C9_starX_C3_star);
  v36: C3_star + AC9_starX -> AC9_starX_C3_star; cytosol*(a*k15*C3_star*AC9_starX - d*k15b*AC9_starX_C3_star);
  v37: C9 + C3_starX -> C9X_C3_star; cytosol*(a*k9*C9*C3_starX - d*k9b*C9X_C3_star);
  v38: AC9 + C3_starX -> AC9X_C3_star; cytosol*(a*k9*AC9*C3_starX - d*k9b*AC9X_C3_star);
  v39: C9_star + C3_starX -> C9_starX_C3_star; cytosol*(a*k9*C9_star*C3_starX - d*k9b*C9_starX_C3_star);
  v40: AC9_star + C3_starX -> AC9_starX_C3_star; cytosol*(a*k9*AC9_star*C3_starX - d*k9b*AC9_starX_C3_star);
  v41: C9X_C3_star + A -> AC9X_C3_star; cytosol*(a*k1*C9X_C3_star*A - d*kb1*AC9X_C3_star);
  v42: C9_starX_C3_star + A -> AC9_starX_C3_star; cytosol*(a*k1*C9_starX_C3_star*A - d*kb1*AC9_starX_C3_star);

  // Species initializations:
  A = 20;
  C9 = 20;
  C9X = 0;
  X = 40;
  AC9X = 0;
  AC9 = 0;
  C3 = 200;
  C3_star = 0;
  C3_starX = 0;
  C9_starX = 0;
  C9_star = 0;
  AC9_star = 0;
  AC9_starX = 0;
  C9X_C3_star = 0;
  AC9X_C3_star = 0;
  C9_starX_C3_star = 0;
  AC9_starX_C3_star = 0;

  // Compartment initializations:
  cytosol = 1;

  // Variable initializations:
  k1 = 0.002;
  kb1 = 0.1;
  k2 = 5e-06;
  k3 = 0.00035;
  k9 = 0.001;
  k9b = 0.001;
  k10 = 0.001;
  k10b = 0.001;
  k13 = 0.002;
  k13b = 0.1;
  k15 = 0.003;
  k15b = 0.001;
  k4 = 0.0002;
  k5 = 0.0002;
  k8 = 0.002;
  k8b = 0.1;
  k11 = 0.001;
  k11b = 0.001;
  k12 = 0.001;
  k12b = 0.001;
  k14 = 0.002;
  k14b = 0.1;
  k6 = 5e-05;
  k7 = 0.0035;
  k16 = 0.001;
  k16prod = 0.02;
  k17 = 0.001;
  k17prod = 0.02;
  k18 = 0.001;
  k18prod = 0.04;
  k19 = 0.001;
  k20 = 0.001;
  k21 = 0.001;
  k22 = 0.001;
  k22prod = 0.2;
  k23 = 0.001;
  k24 = 0.001;
  k25 = 0.001;
  k26 = 0.001;
  k27 = 0.001;
  k28 = 0.001;
  k29 = 0.001;
  k30 = 0.001;
  k31 = 0.001;
  k32 = 0.001;
  a = 1;
  d = 1;
  k41 = 1;
  k42 = 1;

  // Other declarations:
  const cytosol, k1, kb1, k2, k3, k9, k9b, k10, k10b, k13, k13b, k15, k15b;
  const k4, k5, k8, k8b, k11, k11b, k12, k12b, k14, k14b, k6, k7, k16, k16prod;
  const k17, k17prod, k18, k18prod, k19, k20, k21, k22, k22prod, k23, k24;
  const k25, k26, k27, k28, k29, k30, k31, k32, a, d, k41, k42;

  // Unit definitions:
  unit substance = 1e-9 mole;
  unit nM_per_sec = 1e-9 mole / (litre * second);
  unit per_nM_per_sec = litre / (1e-9 mole * second);
  unit nM = 1e-9 mole / litre;
  unit sec_inverse = 1 / second;

  // Display Names:
  substance is "nanomole";
  cytosol is "Cytosol";
  A is "APAF-1";
  C9 is "Caspase 9";
  C9X is "Caspase 9-XIAP complex";
  X is "XIAP";
  AC9X is "APAF-1-Caspase 9-XIAP complex";
  AC9 is "APAF-1-Caspase 9 complex";
  C3 is "Caspase 3";
  C3_star is "Caspase 3 cleaved";
  C3_starX is "Caspase 3 cleaved - XIAP complex";
  C9_starX is "Caspase 9 cleaved-XIAP complex";
  C9_star is "Caspase 9 cleaved";
  AC9_star is "APAF-1-Caspase 9 cleaved complex";
  AC9_starX is "Apaf-1-Caspase 9 cleaved -XIAP complex";
  C9X_C3_star is "Apaf-1-Caspase 9 cleaved -XIAP complex";
  AC9X_C3_star is "Apaf-1-Caspase 9 cleaved -XIAP complex";
  C9_starX_C3_star is "Apaf-1-Caspase 9 cleaved -XIAP complex";
  AC9_starX_C3_star is "Apaf-1-Caspase 9 cleaved -XIAP complex";
  v1 is "Caspase 9 / Apaf-1 binding";
  v2 is "Caspase 3 cleavage by Caspase 9";
  v3 is "Caspase 3 cleavage by Caspase 9-Apaf-1";
  v9 is "Caspase 9 Xiap binding";
  v10 is "Caspase 9-Apaf-1 Xiap binding";
  v13 is "Caspase 9-Xiap Apaf-1 binding";
  v15 is "cleaved Caspase 3-Xiap binding";
  v4 is "Caspase 9 cleavage by cleaved caspase 3";
  v5 is "Caspase 9 cleavage by cleaved caspase 3 when Apaf-1 is bound";
  v8 is "cleaved Caspase 9 Apaf-1 binding";
  v11 is "cleaved Caspase 9 XIAP binding";
  v12 is "cleaved Caspase 9-Apaf-1 XIAP binding";
  v14 is "cleaved Caspase 9-Xiap Apaf-1 binding";
  v6 is "Caspase 3 cleavage by cleaved Caspase 9";
  v7 is "Caspase 3 cleavage by cleaved Caspase 9 - Apaf-1";
  v16 is "Apaf-1 turnover";
  v17 is "Caspase 9 turnover";
  v18 is "Xiap turnover";
  v19 is "Caspase 9-Xiap degradation";
  v20 is "Apaf-1-Caspase 9-Xiap degradation";
  v21 is "Apaf-1-Caspase 9 degradation";
  v22 is "Caspase 3 turnover";
  v23 is "Caspase 3 cleaved degradation";
  v24 is "Caspase 3 cleaved-Xiap degradation";
  v25 is "Caspase 9 cleaved-Xiap degradation";
  v26 is "Caspase 9 cleaved degradation";
  v27 is "Apaf-1 Caspase 9 cleaved degradation";
  v28 is "Apaf-1 Caspase 9 cleaved-Xiap degradation";
  v29 is "Caspase9-Xiap-Caspase3_star degradation";
  v30 is "Apaf-1-Caspase9-Xiap-Caspase3_star degradation";
  v31 is "Caspase9_star-Xiap-Caspase3_star degradation";
  v32 is "Apaf-1-Caspase9_star-Xiap-Caspase3_star degradation";
  v33 is "Cleaved-Caspase 3 binding with Xiap-Caspase 9";
  v34 is "Cleaved-Caspase 3 binding with Apaf-Xiap-Caspase 9";
  v35 is "Cleaved-Caspase 3 binding with Cleaved-Xiap-Caspase 9";
  v36 is "Apaf-Xiap-cleaved Caspase 9 binding with cleaved Caspase 3";
  v37 is "Binding of Caspase 9 to cleaved Caspase 3-Xiap";
  v38 is "Binding of Apaf-Caspase 9 to cleaved Caspase 3-Xiap";
  v39 is "Binding of cleaved Caspase 9 to cleaved Caspase 3-Xiap";
  v40 is "Binding of cleaved Caspase 9-Apaf-1 to cleaved Caspase 3-Xiap";
  v41 is "Binding of Caspase 9-Xiap-cleaved Caspase 3 with Apaf";
  v42 is "Binding of cleaved Caspase 9-Xiap-cleaved Caspase 3 with Apaf";

  // CV terms:
  cytosol identity "http://identifiers.org/obo.go/GO:0005829"
  A hypernym "http://identifiers.org/uniprot/O14727"
  C9 hypernym "http://identifiers.org/uniprot/P55211"
  C9X part "http://identifiers.org/uniprot/P98170",
           "http://identifiers.org/uniprot/P55211"
  X hypernym "http://identifiers.org/uniprot/P98170"
  AC9X part "http://identifiers.org/uniprot/P98170",
            "http://identifiers.org/uniprot/P55211",
            "http://identifiers.org/uniprot/O14727"
  AC9 part "http://identifiers.org/uniprot/P55211",
           "http://identifiers.org/uniprot/O14727"
  C3 hypernym "http://identifiers.org/uniprot/P42574"
  C3_star hypernym "http://identifiers.org/uniprot/P42574"
  C3_starX part "http://identifiers.org/uniprot/P98170",
                "http://identifiers.org/uniprot/P42574"
  C9_starX part "http://identifiers.org/uniprot/P98170",
                "http://identifiers.org/uniprot/P55211"
  C9_star hypernym "http://identifiers.org/uniprot/P55211"
  AC9_star part "http://identifiers.org/uniprot/P55211",
                "http://identifiers.org/uniprot/O14727"
  AC9_starX part "http://identifiers.org/uniprot/P98170",
                 "http://identifiers.org/uniprot/P55211",
                 "http://identifiers.org/uniprot/O14727"
  C9X_C3_star part "http://identifiers.org/uniprot/P98170",
                   "http://identifiers.org/uniprot/P55211"
  AC9X_C3_star part "http://identifiers.org/uniprot/P98170",
                    "http://identifiers.org/uniprot/P55211",
                    "http://identifiers.org/uniprot/O14727"
  C9_starX_C3_star part "http://identifiers.org/uniprot/P42574",
                        "http://identifiers.org/uniprot/P98170",
                        "http://identifiers.org/uniprot/P55211"
  AC9_starX_C3_star part "http://identifiers.org/uniprot/P42574",
                         "http://identifiers.org/uniprot/P55211",
                         "http://identifiers.org/uniprot/P98170",
                         "http://identifiers.org/uniprot/O14727"
  v1 hypernym "http://identifiers.org/obo.go/GO:0005515"
  v2 hypernym "http://identifiers.org/obo.go/GO:0030693",
              "http://identifiers.org/obo.go/GO:0006919"
  v2 identity "http://identifiers.org/ec-code/3.4.22.62"
  v3 identity "http://identifiers.org/ec-code/3.4.22.62"
  v3 hypernym "http://identifiers.org/obo.go/GO:0006919"
  v9 hypernym "http://identifiers.org/obo.go/GO:0043027",
              "http://identifiers.org/obo.go/GO:0005515"
  v10 hypernym "http://identifiers.org/obo.go/GO:0043027",
               "http://identifiers.org/obo.go/GO:0005515"
  v13 hypernym "http://identifiers.org/obo.go/GO:0005515"
  v15 hypernym "http://identifiers.org/obo.go/GO:0043027",
               "http://identifiers.org/obo.go/GO:0005515"
  v4 identity "http://identifiers.org/ec-code/3.4.22.56",
              "http://identifiers.org/obo.go/GO:0030693"
  v5 identity "http://identifiers.org/ec-code/3.4.22.56",
              "http://identifiers.org/obo.go/GO:0030693"
  v8 hypernym "http://identifiers.org/obo.go/GO:0005515"
  v11 hypernym "http://identifiers.org/obo.go/GO:0006412",
               "http://identifiers.org/obo.go/GO:0005515"
  v12 hypernym "http://identifiers.org/obo.go/GO:0043027",
               "http://identifiers.org/obo.go/GO:0005515"
  v14 hypernym "http://identifiers.org/obo.go/GO:0005515"
  v6 hypernym "http://identifiers.org/obo.go/GO:0030693"
  v6 identity "http://identifiers.org/ec-code/3.4.22.62"
  v7 hypernym "http://identifiers.org/obo.go/GO:0030693"
  v7 identity "http://identifiers.org/ec-code/3.4.22.62"
  v16 hypernym "http://identifiers.org/obo.go/GO:0044257"
  v17 hypernym "http://identifiers.org/obo.go/GO:0044257"
  v18 hypernym "http://identifiers.org/obo.go/GO:0044257"
  v19 hypernym "http://identifiers.org/obo.go/GO:0044257"
  v20 hypernym "http://identifiers.org/obo.go/GO:0044257"
  v21 hypernym "http://identifiers.org/obo.go/GO:0044257"
  v22 hypernym "http://identifiers.org/obo.go/GO:0044257"
  v23 hypernym "http://identifiers.org/obo.go/GO:0044257"
  v24 hypernym "http://identifiers.org/obo.go/GO:0044257"
  v25 hypernym "http://identifiers.org/obo.go/GO:0044257"
  v26 hypernym "http://identifiers.org/obo.go/GO:0044257"
  v27 hypernym "http://identifiers.org/obo.go/GO:0044257"
  v28 hypernym "http://identifiers.org/obo.go/GO:0044257"
  v29 hypernym "http://identifiers.org/obo.go/GO:0044257"
  v30 hypernym "http://identifiers.org/obo.go/GO:0044257"
  v31 hypernym "http://identifiers.org/obo.go/GO:0044257"
  v32 hypernym "http://identifiers.org/obo.go/GO:0044257"
  v33 hypernym "http://identifiers.org/obo.go/GO:0005515"
  v34 hypernym "http://identifiers.org/obo.go/GO:0005515"
  v35 hypernym "http://identifiers.org/obo.go/GO:0005515"
  v36 hypernym "http://identifiers.org/obo.go/GO:0005515"
  v37 hypernym "http://identifiers.org/obo.go/GO:0005515"
  v38 hypernym "http://identifiers.org/obo.go/GO:0005515"
  v39 hypernym "http://identifiers.org/obo.go/GO:0005515"
  v40 hypernym "http://identifiers.org/obo.go/GO:0005515"
  v41 hypernym "http://identifiers.org/obo.go/GO:0005515"
  v42 hypernym "http://identifiers.org/obo.go/GO:0005515"
end

Legewie2006_apoptosis_NC is "Legewie2006_apoptosis_NC"

Legewie2006_apoptosis_NC model_entity_is "http://identifiers.org/biomodels.db/MODEL8567941122"
Legewie2006_apoptosis_NC model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000103"
Legewie2006_apoptosis_NC description "http://identifiers.org/pubmed/16978046"
Legewie2006_apoptosis_NC taxon "http://identifiers.org/taxonomy/131567"
Legewie2006_apoptosis_NC hypernym "http://identifiers.org/obo.go/GO:0006915"
Legewie2006_apoptosis_NC parthood "http://identifiers.org/kegg.pathway/hsa04210"
