// Created by libAntimony v2.13.0
model *Vilar2006_TGFbeta()

  // Compartments and Species:
  compartment PM, Endosome;
  substanceOnly species RI in PM, RII in PM, lRIRII in PM, lRIRII_endo in Endosome;
  substanceOnly species RI_endo in Endosome, RII_endo in Endosome;

  // Reactions:
  v1: RII + RI => lRIRII; ka*ligand*RI*RII;
  v2: lRIRII => ; kcd*lRIRII;
  v3: lRIRII => ; klid*lRIRII;
  v4: lRIRII => lRIRII_endo; ki*lRIRII;
  v5:  => RI; pRI;
  v6: RI => ; kcd*RI;
  v7: RI => RI_endo; ki*RI;
  v8: RI_endo => RI; kr*RI_endo;
  v9: lRIRII_endo => RI + RII; kr*lRIRII_endo;
  v10:  => RII; pRII;
  v11: RII => ; kcd*RII;
  v12: RII => RII_endo; ki*RII;
  v13: RII_endo => RII; kr*RII_endo;

  // Events:
  event_0000001: at time >= 2500: ligand = 0.01;

  // Species initializations:
  RI = 20/PM;
  RII = 20/PM;
  lRIRII = 0;
  lRIRII_endo = 40/Endosome;
  RI_endo = 0;
  RII_endo = 0;

  // Compartment initializations:
  PM = 1;
  Endosome = 1;

  // Variable initializations:
  ligand = 3e-05;
  ka = 1;
  kcd = 0.0277777778;
  klid = 0.25;
  ki = 0.3333333333333;
  pRI = 8;
  kr = 0.0333333333333333;
  alpha = 1;
  pRII = 4;

  // Other declarations:
  var ligand;
  const PM, Endosome, ka, kcd, klid, ki, pRI, kr, alpha, pRII;

  // Unit definitions:
  unit substance = item;
  unit time_unit = 3600 second;
  unit min_inv = 1 / 3600 second;

  // Display Names:
  time_unit is "minutes";
  PM is "Plasma membrane";
  RI is "Receptor 1";
  RII is "Receptor 2";
  lRIRII is "ligand receptor complex-plasma membrane";
  lRIRII_endo is "ligand receptor complex-endosome";
  RI_endo is "Receptor 1-endosome";
  RII_endo is "Receptor 2 endosome";
  v1 is "Ligand receptor complex formation";
  v2 is "Ligand receptor complex constitutive degradation";
  v3 is "Ligand independent complex degradation";
  v4 is "Ligand receptor complex internalization";
  v5 is "RI synthesis";
  v6 is "RI constitutive degradation";
  v7 is "RI internalization";
  v8 is "RI recycling";
  v9 is "Ligand Receptor complex recycling";
  v10 is "RII synthesis";
  v11 is "RII constitutive degradation";
  v12 is "RII internalization";
  v13 is "RII recycling";

  // CV terms:
  PM identity "http://identifiers.org/obo.go/GO:0005886"
  Endosome identity "http://identifiers.org/obo.go/GO:0005768"
  RI hypernym "http://identifiers.org/uniprot/P36897"
  RII hypernym "http://identifiers.org/uniprot/P37173"
  lRIRII part "http://identifiers.org/uniprot/P01137",
              "http://identifiers.org/uniprot/P36897",
              "http://identifiers.org/uniprot/P37173"
  lRIRII_endo part "http://identifiers.org/uniprot/P01137",
                   "http://identifiers.org/uniprot/P36897",
                   "http://identifiers.org/uniprot/P37173"
  RI_endo hypernym "http://identifiers.org/uniprot/P36897"
  RII_endo hypernym "http://identifiers.org/uniprot/P37173"
  v1 identity "http://identifiers.org/obo.go/GO:0050431",
              "http://identifiers.org/obo.go/GO:0007181"
  v2 hypernym "http://identifiers.org/obo.go/GO:0030512"
  v3 hypernym "http://identifiers.org/obo.go/GO:0030512"
  v4 hypernym "http://identifiers.org/obo.go/GO:0030511"
  v5 hypernym "http://identifiers.org/obo.go/GO:0006412"
  v6 hypernym "http://identifiers.org/obo.go/GO:0032801"
  v7 hypernym "http://identifiers.org/obo.go/GO:0031623"
  v8 hypernym "http://identifiers.org/obo.go/GO:0001881"
  v9 hypernym "http://identifiers.org/obo.go/GO:0001881"
  v10 hypernym "http://identifiers.org/obo.go/GO:0006412"
  v11 hypernym "http://identifiers.org/obo.go/GO:0032801"
  v12 hypernym "http://identifiers.org/obo.go/GO:0031623"
  v13 hypernym "http://identifiers.org/obo.go/GO:0001881"
end

Vilar2006_TGFbeta is "Vilar2006_TGFbeta"

Vilar2006_TGFbeta model_entity_is "http://identifiers.org/biomodels.db/MODEL4023382414"
Vilar2006_TGFbeta model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000101"
Vilar2006_TGFbeta description "http://identifiers.org/pubmed/16446785"
Vilar2006_TGFbeta taxon "http://identifiers.org/taxonomy/131567"
Vilar2006_TGFbeta part "http://identifiers.org/reactome/REACT_6844.3"
Vilar2006_TGFbeta hypernym "http://identifiers.org/obo.go/GO:0007179"
Vilar2006_TGFbeta part "http://identifiers.org/kegg.pathway/hsa04350"
