// Created by libAntimony v2.13.0
model *Proctor2005_Hsp90()

  // Compartments and Species:
  compartment compartment_;
  substanceOnly species Hsp90 in compartment_, HCom in compartment_, HSF1 in compartment_;
  substanceOnly species MisP in compartment_, MCom in compartment_, TriH in compartment_;
  substanceOnly species DiH in compartment_, NatP in compartment_, AggP in compartment_;
  substanceOnly species HSE in compartment_, HSETriH in compartment_, X in compartment_;
  substanceOnly species ROS in compartment_, ATP in compartment_, ADP in compartment_;
  substanceOnly species $source in compartment_;

  // Reactions:
  proteinSynthesis: 0 $source => NatP; k1;
  misfolding: NatP + ROS => MisP + ROS; k2*NatP*ROS;
  Hsp90MisPBinding: MisP + Hsp90 => MCom; k3*MisP*Hsp90;
  unsuccessulRefolding: MCom => MisP + Hsp90; k4*MCom;
  refolding: MCom + ATP => Hsp90 + NatP + ADP; k5*MCom*ATP;
  proteinDegradation: MisP + ATP => ADP; k6*MisP*ATP;
  proteinAggregation1: 2 MisP => AggP; (MisP - 1)*k7*MisP/2;
  proteinAggregation2: MisP + AggP => 2 AggP; k7*MisP*AggP;
  Hsp90HSF1Binding: Hsp90 + HSF1 => HCom; k8*Hsp90*HSF1;
  Hsp90HSF1Release: HCom => Hsp90 + HSF1; k9*HCom;
  dimerisation: 2 HSF1 => DiH; (HSF1 - 1)*k10*HSF1/2;
  trimerisation: HSF1 + DiH => TriH; k11*HSF1*DiH;
  deTrimerisation: TriH => HSF1 + DiH; k12*TriH;
  deDimerisation: DiH => 2 HSF1; k13*DiH;
  HSETriHBinding: TriH + HSE => HSETriH; k14*HSE*TriH;
  HSETriHRelease: HSETriH => HSE + TriH; k15*HSETriH;
  Hsp90Transcription: HSETriH => HSETriH + Hsp90; k16*HSETriH;
  Hsp90Degradation: Hsp90 + ATP => ADP; k17*Hsp90*ATP;
  countTime: 0 $source => X; 1;
  ATPformation: ADP => ATP; k18*ADP;
  ATPconsumption: ATP => ADP; k19*ATP;
  radicalFormation: 0 $source => ROS; k20;
  radicalScavenging: ROS => ; k21*ROS;

  // Species initializations:
  Hsp90 = 300000/compartment_;
  HCom = 5900/compartment_;
  HSF1 = 100/compartment_;
  MisP = 0;
  MCom = 0;
  TriH = 0;
  DiH = 0;
  NatP = 6000000/compartment_;
  AggP = 0;
  HSE = 1/compartment_;
  HSETriH = 0;
  X = 0;
  ROS = 100/compartment_;
  ATP = 10000/compartment_;
  ADP = 1000/compartment_;
  source = 0;

  // Compartment initializations:
  compartment_ = 1;

  // Variable initializations:
  k1 = 10;
  k2 = 2e-05;
  k3 = 50;
  k4 = 1e-05;
  k5 = 4e-06;
  k6 = 6e-07;
  k7 = 1e-07;
  k8 = 500;
  k9 = 1;
  k10 = 0.01;
  k11 = 100;
  k12 = 0.5;
  k13 = 0.5;
  k14 = 0.05;
  k15 = 0.08;
  k16 = 1000;
  k17 = 8.02e-09;
  k18 = 12;
  k19 = 0.02;
  k20 = 0.1;
  k21 = 0.001;

  // Other declarations:
  const compartment_, k1, k2, k3, k4, k5, k6, k7, k8, k9, k10, k11, k12, k13;
  const k14, k15, k16, k17, k18, k19, k20, k21;

  // Unit definitions:
  unit substance = item;

  // Display Names:
  unsuccessulRefolding is "unsuccessfulRefolding";

  // CV terms:
  compartment_ hypernym "http://identifiers.org/go/GO:0005623"
  Hsp90 identity "http://identifiers.org/interpro/IPR001404"
  HCom hypernym "http://identifiers.org/go/GO:0043234"
  HSF1 hypernym "http://identifiers.org/interpro/IPR000232"
  MCom hypernym "http://identifiers.org/go/GO:0043234"
  TriH hypernym "http://identifiers.org/go/GO:0043234"
  TriH part "http://identifiers.org/interpro/IPR000232"
  DiH hypernym "http://identifiers.org/go/GO:0043234"
  DiH part "http://identifiers.org/interpro/IPR000232"
  ROS hypernym "http://identifiers.org/chebi/CHEBI:26523"
  ATP identity "http://identifiers.org/chebi/CHEBI:15422",
               "http://identifiers.org/kegg.compound/C00002"
  ADP identity "http://identifiers.org/chebi/CHEBI:16761",
               "http://identifiers.org/kegg.compound/C00008"
  proteinSynthesis hypernym "http://identifiers.org/go/GO:0009059"
  misfolding version "http://identifiers.org/go/GO:0022417"
  Hsp90MisPBinding hypernym "http://identifiers.org/go/GO:0051879"
  unsuccessulRefolding hypernym "http://identifiers.org/go/GO:0043624"
  refolding hypernym "http://identifiers.org/go/GO:0042026",
                     "http://identifiers.org/go/GO:0016887"
  proteinDegradation hypernym "http://identifiers.org/go/GO:0016887"
  proteinAggregation1 hypernym "http://identifiers.org/go/GO:0043623"
  proteinAggregation2 hypernym "http://identifiers.org/go/GO:0043623"
  Hsp90HSF1Binding hypernym "http://identifiers.org/go/GO:0051879"
  Hsp90HSF1Release hypernym "http://identifiers.org/go/GO:0043624"
  dimerisation hypernym "http://identifiers.org/go/GO:0043623"
  trimerisation hypernym "http://identifiers.org/go/GO:0043623"
  deTrimerisation hypernym "http://identifiers.org/go/GO:0043624"
  deDimerisation hypernym "http://identifiers.org/go/GO:0043624"
  HSETriHBinding hypernym "http://identifiers.org/go/GO:0043623"
  HSETriHRelease hypernym "http://identifiers.org/go/GO:0043624"
  Hsp90Transcription hypernym "http://identifiers.org/go/GO:0006351"
  Hsp90Degradation hypernym "http://identifiers.org/go/GO:0044257",
                            "http://identifiers.org/go/GO:0016887"
  ATPformation hypernym "http://identifiers.org/go/GO:0006757"
  ATPconsumption hypernym "http://identifiers.org/go/GO:0016887"
  radicalFormation parthood "http://identifiers.org/go/GO:0006800"
  radicalScavenging hypernym "http://identifiers.org/go/GO:0016209"
end

Proctor2005_Hsp90 is "Proctor2005 - Actions of chaperones and their role in ageing"

Proctor2005_Hsp90 model_entity_is "http://identifiers.org/biomodels.db/MODEL2223638385"
Proctor2005_Hsp90 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000091"
Proctor2005_Hsp90 description "http://identifiers.org/pubmed/15610770"
Proctor2005_Hsp90 hypernym "http://identifiers.org/go/GO:0051085",
                           "http://identifiers.org/go/GO:0007569",
                           "http://identifiers.org/go/GO:0009408"
Proctor2005_Hsp90 taxon "http://identifiers.org/taxonomy/131567"
Proctor2005_Hsp90 version "http://identifiers.org/doid/DOID:10652",
                          "http://identifiers.org/doid/DOID:14330",
                          "http://identifiers.org/doid/DOID:83"
