// Created by libAntimony v2.13.0
model *Src_MitoticActivation()

  // Compartments and Species:
  compartment default;
  species srci in default, srco in default, srca in default, srcc in default;
  species Cbp_P_CSK in default, CSK_cytoplasm in default, PTP in default;
  species PTP_pY789 in default, Cbp in default, Cbp_P in default;

  // Assignment Rules:
  ptp_activity := PTP_background + Kser*PTP_pY789;
  src_activity := rho_srco*srco + rho_srca*srca + src_background + rho_srcc*srcc;

  // Reactions:
  v1: srci -> srco; (k2*ptp_activity*srci - k1*Cbp_P_CSK*srco)*default;
  v2: srco -> srca; (k3*src_activity*srco - p1*srca)*default;
  v3: srca -> srcc; (k1*Cbp_P_CSK*srca - k2*ptp_activity*srcc)*default;
  v4: srcc => srci; default*k4*p1*srcc;
  CSK_translocation: CSK_cytoplasm + Cbp_P -> Cbp_P_CSK; (Cbp_P*kCSKon*CSK_cytoplasm - kCSKoff*Cbp_P_CSK)*default;
  PTP_phosphorylation: PTP -> PTP_pY789; default*((kPTP*src_activity + p3)*PTP - p2*PTP_pY789);
  Cbp_phosphorylation: Cbp => Cbp_P; kCbp*src_activity*Cbp*default;

  // Species initializations:
  srci = 1;
  srco = 0;
  srca = 0;
  srcc = 0;
  Cbp_P_CSK = 0;
  CSK_cytoplasm = 1;
  PTP = 1;
  PTP_pY789 = 0;
  Cbp = 1;
  Cbp_P = 0;

  // Compartment initializations:
  default = 1;

  // Variable initializations:
  k1 = 1;
  k2 = 0.8;
  k3 = 1;
  k4 = 10;
  kPTP = 1;
  kCbp = 1;
  p1 = 0.05;
  p2 = 0.15;
  p3 = 0.035;
  src_background = 0.0001;
  PTP_background = 0;
  kCSKon = 0.1;
  kCSKoff = 0.01;
  rho_srca = 1;
  rho_srco = 0;
  rho_srcc = 1;
  Kser = 1;
  acsk0 = 0;

  // Other declarations:
  var ptp_activity, src_activity;
  const default, k1, k2, k3, k4, kPTP, kCbp, p1, p2, p3, src_background, PTP_background;
  const kCSKon, kCSKoff, rho_srca, rho_srco, rho_srcc, Kser, acsk0;

  // CV terms:
  default identity "http://identifiers.org/go/GO:0005623"
  srci hypernym "http://identifiers.org/uniprot/P12931"
  srco hypernym "http://identifiers.org/uniprot/P12931"
  srca hypernym "http://identifiers.org/uniprot/P12931"
  srcc hypernym "http://identifiers.org/uniprot/P12931"
  Cbp_P_CSK part "http://identifiers.org/uniprot/P41240",
                 "http://identifiers.org/uniprot/Q9NWQ8"
  CSK_cytoplasm identity "http://identifiers.org/uniprot/P41240"
  PTP hypernym "http://identifiers.org/uniprot/P18433"
  PTP_pY789 hypernym "http://identifiers.org/uniprot/P18433"
  Cbp hypernym "http://identifiers.org/uniprot/Q9NWQ8"
  Cbp_P hypernym "http://identifiers.org/uniprot/Q9NWQ8"
  v1 hypernym "http://identifiers.org/ec-code/2.7.10.2",
              "http://identifiers.org/go/GO:0004713"
  v2 hypernym "http://identifiers.org/ec-code/2.7.10.2",
              "http://identifiers.org/go/GO:0004713"
  v3 hypernym "http://identifiers.org/ec-code/2.7.10.2",
              "http://identifiers.org/go/GO:0004713"
  v4 hypernym "http://identifiers.org/ec-code/3.1.3.48",
              "http://identifiers.org/go/GO:0004725"
  CSK_translocation part "http://identifiers.org/go/GO:0006461",
                         "http://identifiers.org/go/GO:0006612"
  PTP_phosphorylation hypernym "http://identifiers.org/ec-code/2.7.10.2",
                               "http://identifiers.org/go/GO:0004713"
  Cbp_phosphorylation hypernym "http://identifiers.org/ec-code/2.7.10.2",
                               "http://identifiers.org/go/GO:0004713"
end

Src_MitoticActivation is "Fuss2006_MitoticActivation"

Src_MitoticActivation model_entity_is "http://identifiers.org/biomodels.db/MODEL7146478294"
Src_MitoticActivation model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000069"
Src_MitoticActivation description "http://identifiers.org/pubmed/16873466"
Src_MitoticActivation taxon "http://identifiers.org/taxonomy/9606"
Src_MitoticActivation hypernym "http://identifiers.org/reactome/REACT_152",
                               "http://identifiers.org/go/GO:0000278"
