// Created by libAntimony v2.13.0
model *Curien2003_MetThr_synthesis()

  // Compartments and Species:
  compartment compartment_;
  species Phser in compartment_, $Thr in compartment_, $Cystathionine in compartment_;
  species $Hser in compartment_, $Phi in compartment_, $Cys in compartment_;
  species $AdoMet in compartment_, $CGS in compartment_, $TS in compartment_;

  // Reactions:
  v1: $Hser -> Phser; compartment_*v1_V0;
  vCys: Phser + $Cys -> $Cystathionine + $Phi; CGS*(vCys_kcat2/(1 + vCys_KmCYS/Cys))*Phser/(Phser + vCys_KmPHSER*(1 + Phi/vCys_Ki2)/(1 + vCys_KmCYS/Cys));
  vThr: Phser -> $Thr + $Phi; TS*(5.9e-4 + 0.062*AdoMet^2.9/(32^2.9 + AdoMet^2.9))*Phser/(1 + Phi/vThr_Ki3);

  // Species initializations:
  Phser = 0;
  Thr = 0;
  Cystathionine = 0;
  Hser = 0;
  Phi = 10000;
  Cys = 15;
  AdoMet = 20;
  CGS = 0.7;
  TS = 5;

  // Compartment initializations:
  compartment_ = 1;

  // Variable initializations:
  v1_V0 = 1;
  v1_V0 has microM_per_second;
  vCys_kcat2 = 30;
  vCys_kcat2 has microM;
  vCys_KmCYS = 460;
  vCys_KmCYS has microM;
  vCys_KmPHSER = 2500;
  vCys_KmPHSER has microM;
  vCys_Ki2 = 2000;
  vCys_Ki2 has microM;
  vThr_Ki3 = 1000;
  vThr_Ki3 has microM;

  // Other declarations:
  const compartment_;

  // Unit definitions:
  unit substance = 1e-6 mole;
  unit microM = 1e-6 mole / litre;
  unit sec_inverse = 1 / second;
  unit microM_per_second = 1e-6 mole / (litre * second);

  // Display Names:
  substance is "micromole";
  compartment_ is "Cell";
  Phser is "Phosphohomoserine";
  Thr is "Threonine";
  Hser is "Homoserine";
  Phi is "Inorganic phosphate";
  Cys is "Cysteine";
  AdoMet is "S-adenosylmethionine";
  CGS is "Cystathionine gamma-synthase";
  TS is "Threonine synthase";
  v1 is "Phosphohomoserine synthesis";
  vCys is "Cystathionine gamma-synthase";
  vThr is "Threonine Synthase";

  // CV terms:
  compartment_ identity "http://identifiers.org/obo.go/GO:0005623"
  Phser identity "http://identifiers.org/obo.chebi/CHEBI:15961",
                 "http://identifiers.org/kegg.compound/C01102"
  Thr identity "http://identifiers.org/obo.chebi/CHEBI:16857",
               "http://identifiers.org/kegg.compound/C00188"
  Cystathionine identity "http://identifiers.org/obo.chebi/CHEBI:17482",
                         "http://identifiers.org/kegg.compound/C02291"
  Hser identity "http://identifiers.org/obo.chebi/CHEBI:15699",
                "http://identifiers.org/kegg.compound/C00263"
  Phi identity "http://identifiers.org/obo.chebi/CHEBI:18367",
               "http://identifiers.org/kegg.compound/C00009"
  Cys identity "http://identifiers.org/obo.chebi/CHEBI:17561",
               "http://identifiers.org/kegg.compound/C00097"
  AdoMet identity "http://identifiers.org/obo.chebi/CHEBI:15414",
                  "http://identifiers.org/kegg.compound/C00019"
  CGS hypernym "http://identifiers.org/uniprot/P55217"
  TS hypernym "http://identifiers.org/uniprot/Q9S7B5"
  v1 hypernym "http://identifiers.org/ec-code/2.7.1.39",
              "http://identifiers.org/obo.go/GO:0004413"
  v1 identity "http://identifiers.org/kegg.reaction/R01775"
  vCys hypernym "http://identifiers.org/ec-code/2.5.1.48",
                "http://identifiers.org/obo.go/GO:0003962"
  vThr identity "http://identifiers.org/kegg.reaction/R01466"
  vThr hypernym "http://identifiers.org/ec-code/4.2.3.1",
                "http://identifiers.org/obo.go/GO:0004795"
end

Curien2003_MetThr_synthesis is "Curien2003_MetThr_synthesis"

Curien2003_MetThr_synthesis model_entity_is "http://identifiers.org/biomodels.db/MODEL6624146302"
Curien2003_MetThr_synthesis model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000068"
Curien2003_MetThr_synthesis description "http://identifiers.org/pubmed/14622248"
Curien2003_MetThr_synthesis part "http://identifiers.org/obo.go/GO:0019283",
                                 "http://identifiers.org/obo.go/GO:0009088"
Curien2003_MetThr_synthesis part "http://identifiers.org/kegg.pathway/map00260",
                                 "http://identifiers.org/kegg.pathway/map00271"
Curien2003_MetThr_synthesis taxon "http://identifiers.org/taxonomy/3702"
