// Created by libAntimony v2.13.0
model *Galazzo1990_FermentationPathwayKinetics()

  // Compartments and Species:
  compartment extracellular, cytoplasm;
  species Glci in cytoplasm, ATP in cytoplasm, G6P in cytoplasm, FDP in cytoplasm;
  species PEP in cytoplasm, $Gly in cytoplasm, $EtOH in cytoplasm, $Carbo in cytoplasm;
  species $Glco in extracellular;

  // Assignment Rules:
  VappGly := parameter_4*G6P^parameter_5/(parameter_6^parameter_5 + G6P^parameter_5);
  VratioVmax := Vhk/(cytoplasm*parameter_7);

  // Reactions:
  Vhk: ATP + Glci -> G6P; cytoplasm*Vhk_Vm2/(1 + Vhk_Km2Glc/Glci + Vhk_Km2ATP/ATP + Vhk_Ks2Glc*Vhk_Km2ATP/(Glci*ATP));
  Vin: $Glco -> Glci; cytoplasm*(Vin_Vm1 - Vin_Ki1G6P*G6P);
  Vpol: ATP + G6P -> $Carbo; cytoplasm*1.1*Vpol_Vm3*G6P^Vpol_n3/(Vpol_K3Gly^Vpol_n3 + G6P^Vpol_n3)/(1 + (Vpol_Km30/0.7)*(1 + Vpol_Km3G6P/G6P));
  Vpfk: ATP + G6P -> FDP; ((cytoplasm*Vpfk_Vm4*Vpfk_g4R*0.3*G6P/Vpfk_K4F6P)*ATP/Vpfk_K4ATP)*(1 + 0.3*G6P/Vpfk_K4F6P + ATP/Vpfk_K4ATP + (Vpfk_g4R*0.3*G6P/Vpfk_K4F6P)*ATP/Vpfk_K4ATP)/((1 + 0.3*G6P/Vpfk_K4F6P + ATP/Vpfk_K4ATP + (Vpfk_g4R*0.3*G6P/Vpfk_K4F6P)*ATP/Vpfk_K4ATP)^2 + Vpfk_L40*((1 + Vpfk_c4AMP*(3 - ATP - 0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5))/Vpfk_K4AMP)/(1 + (3 - ATP - 0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5))/Vpfk_K4AMP))^2*(1 + Vpfk_c4F6P*0.3*G6P/Vpfk_K4F6P + Vpfk_c4ATP*ATP/Vpfk_K4ATP + (Vpfk_gT*Vpfk_c4F6P*0.3*G6P/Vpfk_K4F6P)*Vpfk_c4ATP*ATP/Vpfk_K4ATP)^2);
  Vgapd: FDP -> 2 ATP + 2 PEP; cytoplasm*Vgapd_Vm5/(1 + Vgapd_K5G3P/(0.01*FDP) + (Vgapd_K5NAD/Vgapd_NAD + Vgapd_K5G3P*Vgapd_K5NAD/(Vgapd_NAD*0.01*FDP) + Vgapd_K5G3P*Vgapd_K5NAD*Vgapd_NADH/(Vgapd_NAD*0.01*FDP*Vgapd_K5NADH))*(1 + 0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5)/Vgapd_K5ADP + (3 - ATP - 0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5))/Vgapd_K5AMP + ATP/Vgapd_K5ATP));
  Vpk: PEP -> ATP + $EtOH; cytoplasm*Vpk_Vm6*((PEP/Vpk_K6PEP)*0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5)/Vpk_K6ADP)*(Vpk_g6R*(1 + PEP/Vpk_K6PEP + 0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5)/Vpk_K6ADP + (Vpk_g6R*PEP/Vpk_K6PEP)*0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5)/Vpk_K6ADP) + ((Vpk_q6*Vpk_L60*((1 + Vpk_c6FDP*FDP/Vpk_K6FDP)/(1 + FDP/Vpk_K6FDP))^2*Vpk_g6T*Vpk_c6PEP*PEP/Vpk_K6PEP)*Vpk_c6ADP*0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5)/Vpk_K6ADP)*(1 + Vpk_c6PEP*PEP/Vpk_K6PEP + Vpk_c6ADP*0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5)/Vpk_K6ADP + (Vpk_g6T*Vpk_c6PEP*PEP/Vpk_K6PEP)*Vpk_c6ADP*0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5)/Vpk_K6ADP))/((1 + 9.55*10^-9/Vpk_h6)*((1 + PEP/Vpk_K6PEP + 0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5)/Vpk_K6ADP + (Vpk_g6R*PEP/Vpk_K6PEP)*0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5)/Vpk_K6ADP)^2 + Vpk_L60*((1 + Vpk_c6FDP*FDP/Vpk_K6FDP)/(1 + FDP/Vpk_K6FDP))^2*(1 + Vpk_c6PEP*PEP/Vpk_K6PEP + Vpk_c6ADP*0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5)/Vpk_K6ADP + (Vpk_g6T*Vpk_c6PEP*PEP/Vpk_K6PEP)*Vpk_c6ADP*0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5)/Vpk_K6ADP)^2));
  Vgol: 0.5 FDP -> $Gly; Vgol_Vm7*cytoplasm*((PEP/Vgol_K6PEP)*0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5)/Vgol_K6ADP)*(Vgol_g6R*(1 + PEP/Vgol_K6PEP + 0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5)/Vgol_K6ADP + (Vgol_g6R*PEP/Vgol_K6PEP)*0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5)/Vgol_K6ADP) + ((Vgol_q6*Vgol_L60*((1 + Vgol_c6FDP*FDP/Vgol_K6FDP)/(1 + FDP/Vgol_K6FDP))^2*Vgol_g6T*Vgol_c6PEP*PEP/Vgol_K6PEP)*Vgol_c6ADP*0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5)/Vgol_K6ADP)*(1 + Vgol_c6PEP*PEP/Vgol_K6PEP + Vgol_c6ADP*0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5)/Vgol_K6ADP + (Vgol_g6T*Vgol_c6PEP*PEP/Vgol_K6PEP)*Vgol_c6ADP*0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5)/Vgol_K6ADP))/((1 + 9.55*10^-9/Vgol_h6)*((1 + PEP/Vgol_K6PEP + 0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5)/Vgol_K6ADP + (Vgol_g6R*PEP/Vgol_K6PEP)*0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5)/Vgol_K6ADP)^2 + Vgol_L60*((1 + Vgol_c6FDP*FDP/Vgol_K6FDP)/(1 + FDP/Vgol_K6FDP))^2*(1 + Vgol_c6PEP*PEP/Vgol_K6PEP + Vgol_c6ADP*0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5)/Vgol_K6ADP + (Vgol_g6T*Vgol_c6PEP*PEP/Vgol_K6PEP)*Vgol_c6ADP*0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5)/Vgol_K6ADP)^2));
  Vatpase: ATP -> ; cytoplasm*Vatpase_Vm8*ATP;

  // Species initializations:
  Glci = 0.0345;
  ATP = 1.19;
  G6P = 1.011;
  FDP = 9.144;
  PEP = 0.0095;
  Gly = 0;
  EtOH = 0;
  Carbo = 0;
  Glco = 1;

  // Compartment initializations:
  extracellular = 1;
  cytoplasm = 1;
  VappGly has mM_per_minute;

  // Variable initializations:
  parameter_4 = 14.31;
  parameter_4 has mM_per_minute;
  parameter_5 = 8.25;
  parameter_5 has dimensionless;
  parameter_6 = 2;
  parameter_6 has mM;
  VratioVmax has dimensionless;
  parameter_7 = 68.5;
  parameter_7 has mM_per_minute;
  Vin_Vm1 = 19.7;
  Vin_Vm1 has mM_per_minute;
  Vin_Ki1G6P = 3.7;
  Vin_Ki1G6P has min_inv;
  Vhk_Vm2 = 68.5;
  Vhk_Vm2 has mM_per_minute;
  Vhk_Km2Glc = 0.11;
  Vhk_Km2Glc has mM;
  Vhk_Km2ATP = 0.1;
  Vhk_Km2ATP has mM;
  Vhk_Ks2Glc = 0.0062;
  Vhk_Ks2Glc has mM;
  Vpol_Vm3 = 14.31;
  Vpol_Vm3 has mM_per_minute;
  Vpol_n3 = 8.25;
  Vpol_n3 has dimensionless;
  Vpol_K3Gly = 2;
  Vpol_K3Gly has mM;
  Vpol_Km30 = 1;
  Vpol_Km30 has mM;
  Vpol_Km3G6P = 1.1;
  Vpol_Km3G6P has mM;
  Vpfk_Vm4 = 31.7;
  Vpfk_Vm4 has mM_per_minute;
  Vpfk_g4R = 10;
  Vpfk_g4R has dimensionless;
  Vpfk_K4F6P = 1;
  Vpfk_K4F6P has mM;
  Vpfk_K4ATP = 0.06;
  Vpfk_K4ATP has mM;
  Vpfk_L40 = 3342;
  Vpfk_L40 has dimensionless;
  Vpfk_c4AMP = 0.019;
  Vpfk_c4AMP has dimensionless;
  Vpfk_K4AMP = 0.025;
  Vpfk_K4AMP has mM;
  Vpfk_c4F6P = 0.0005;
  Vpfk_c4F6P has dimensionless;
  Vpfk_c4ATP = 1;
  Vpfk_c4ATP has dimensionless;
  Vpfk_gT = 1;
  Vpfk_gT has dimensionless;
  Vgapd_Vm5 = 49.9;
  Vgapd_Vm5 has mM_per_minute;
  Vgapd_K5G3P = 0.0025;
  Vgapd_K5G3P has mM;
  Vgapd_K5NAD = 0.18;
  Vgapd_K5NAD has dimensionless;
  Vgapd_NAD = 1.91939;
  Vgapd_NAD has mM;
  Vgapd_NADH = 0.0806142;
  Vgapd_NADH has mM;
  Vgapd_K5NADH = 0.0003;
  Vgapd_K5NADH has mM;
  Vgapd_K5ADP = 1.5;
  Vgapd_K5ADP has mM;
  Vgapd_K5AMP = 1.1;
  Vgapd_K5AMP has mM;
  Vgapd_K5ATP = 2.5;
  Vgapd_K5ATP has mM;
  Vpk_Vm6 = 3440;
  Vpk_Vm6 has mM_per_minute;
  Vpk_K6PEP = 0.00793966;
  Vpk_K6PEP has mM;
  Vpk_K6ADP = 5;
  Vpk_K6ADP has mM;
  Vpk_g6R = 0.1;
  Vpk_g6R has dimensionless;
  Vpk_q6 = 1;
  Vpk_q6 has dimensionless;
  Vpk_L60 = 164.084;
  Vpk_L60 has dimensionless;
  Vpk_c6FDP = 0.01;
  Vpk_c6FDP has dimensionless;
  Vpk_K6FDP = 0.2;
  Vpk_K6FDP has mM;
  Vpk_g6T = 1;
  Vpk_g6T has dimensionless;
  Vpk_c6PEP = 0.000158793;
  Vpk_c6PEP has dimensionless;
  Vpk_c6ADP = 1;
  Vpk_c6ADP has dimensionless;
  Vpk_h6 = 1.14815e-07;
  Vpk_h6 has dimensionless;
  Vgol_Vm7 = 203;
  Vgol_Vm7 has mM_per_minute;
  Vgol_K6PEP = 0.00793966;
  Vgol_K6PEP has mM;
  Vgol_K6ADP = 5;
  Vgol_K6ADP has mM;
  Vgol_g6R = 0.1;
  Vgol_g6R has dimensionless;
  Vgol_q6 = 1;
  Vgol_q6 has dimensionless;
  Vgol_L60 = 164.084;
  Vgol_L60 has dimensionless;
  Vgol_c6FDP = 0.01;
  Vgol_c6FDP has dimensionless;
  Vgol_K6FDP = 0.2;
  Vgol_K6FDP has mM;
  Vgol_g6T = 1;
  Vgol_g6T has dimensionless;
  Vgol_c6PEP = 0.000158793;
  Vgol_c6PEP has dimensionless;
  Vgol_c6ADP = 1;
  Vgol_c6ADP has dimensionless;
  Vgol_h6 = 1.14815e-07;
  Vgol_h6 has dimensionless;
  Vatpase_Vm8 = 25.1;
  Vatpase_Vm8 has min_inv;

  // Other declarations:
  var VappGly, VratioVmax;
  const extracellular, cytoplasm, parameter_4, parameter_5, parameter_6, parameter_7;

  // Unit definitions:
  unit substance = 1e-3 mole;
  unit time_unit = 60 second;
  unit mM = 1e-3 mole / litre;
  unit mM_per_minute = 1e-3 mole / (litre * 60 second);
  unit min_inv = 1 / 60 second;

  // Display Names:
  substance is "millimole";
  time_unit is "minute";
  mM is "milliMolar";
  mM_per_minute is "mM per minute";
  min_inv is "minute_inverse";
  extracellular is "Extracellular";
  cytoplasm is "Cytoplasm";
  Glci is "Glucose inside the cell";
  G6P is "Glucose 6-phosphate";
  FDP is "Fructose 1,6-phosphate";
  PEP is "Phosphoenol pyruvate";
  Gly is "Glycerol";
  EtOH is "Ethanol";
  Carbo is "Glycogen and Trehalose";
  Glco is "Glucose outside the cell";
  parameter_4 is "Trehalose and Glycogen formation_Vm3";
  parameter_5 is "Trehalose and Glycogen formation_n3";
  parameter_6 is "Trehalose and Glycogen formation_K3Gly";
  VratioVmax is "VratioVmax_ATP";
  Vhk is "Hexokinase";
  parameter_7 is "Hexokinase_Vm2";
  Vin is "Glucose in";
  Vpol is "Trehalose and Glycogen formation";
  Vpfk is "Phosphofructokinase";
  Vgapd is "GAPD";
  Vpk is "Pyruvate kinase";
  Vgol is "Glycerol synthesis";
  Vatpase is "ATPase";

  // CV terms:
  extracellular identity "http://identifiers.org/go/GO:0005576"
  cytoplasm identity "http://identifiers.org/go/GO:0005737"
  Glci identity "http://identifiers.org/chebi/CHEBI:17234",
                "http://identifiers.org/kegg.compound/C00293"
  ATP identity "http://identifiers.org/chebi/CHEBI:15422",
               "http://identifiers.org/kegg.compound/C00002"
  G6P identity "http://identifiers.org/chebi/CHEBI:17665",
               "http://identifiers.org/kegg.compound/C00668"
  FDP identity "http://identifiers.org/chebi/CHEBI:16905",
               "http://identifiers.org/kegg.compound/C00354"
  PEP identity "http://identifiers.org/chebi/CHEBI:18021",
               "http://identifiers.org/kegg.compound/C00074"
  Gly identity "http://identifiers.org/chebi/CHEBI:17754",
               "http://identifiers.org/kegg.compound/C00116"
  EtOH identity "http://identifiers.org/chebi/CHEBI:16236",
                "http://identifiers.org/kegg.compound/C00469"
  Carbo part "http://identifiers.org/chebi/CHEBI:28087",
             "http://identifiers.org/chebi/CHEBI:27082"
  Carbo part "http://identifiers.org/kegg.compound/C00182",
             "http://identifiers.org/kegg.compound/C01083",
             "http://identifiers.org/chebi/CHEBI:28087"
  Glco identity "http://identifiers.org/chebi/CHEBI:17234",
                "http://identifiers.org/kegg.compound/C00293"
  Vhk homolog "http://identifiers.org/reactome/REACT_1318"
  Vhk identity "http://identifiers.org/ec-code/2.7.1.2",
               "http://identifiers.org/kegg.reaction/R00299"
  Vin homolog "http://identifiers.org/reactome/REACT_2092"
  Vin identity "http://identifiers.org/go/GO:0046323"
  Vpol homolog "http://identifiers.org/reactome/REACT_1736"
  Vpol part "http://identifiers.org/go/GO:0005978",
            "http://identifiers.org/go/GO:0005992"
  Vpfk part "http://identifiers.org/reactome/REACT_736",
            "http://identifiers.org/reactome/REACT_1164"
  Vpfk part "http://identifiers.org/kegg.reaction/R00771",
            "http://identifiers.org/kegg.reaction/R00756"
  Vgapd part "http://identifiers.org/kegg.reaction/R00658",
             "http://identifiers.org/kegg.reaction/R01518",
             "http://identifiers.org/kegg.reaction/R01512",
             "http://identifiers.org/kegg.reaction/R01061",
             "http://identifiers.org/kegg.reaction/R01015",
             "http://identifiers.org/kegg.reaction/R01070"
  Vgapd part "http://identifiers.org/ec-code/2.7.2.3",
             "http://identifiers.org/ec-code/5.4.2.1",
             "http://identifiers.org/ec-code/1.2.1.12",
             "http://identifiers.org/ec-code/5.3.1.1",
             "http://identifiers.org/ec-code/4.1.2.13",
             "http://identifiers.org/ec-code/4.2.1.11"
  Vpk hypernym "http://identifiers.org/go/GO:0043458"
  Vpk identity "http://identifiers.org/ec-code/2.7.1.40"
  Vgol hypernym "http://identifiers.org/go/GO:0006114"
  Vatpase hypernym "http://identifiers.org/ec-code/3.6.1.3",
                   "http://identifiers.org/go/GO:0016887"
end

Galazzo1990_FermentationPathwayKinetics is "Galazzo1990_FermentationPathwayKinetics"

Galazzo1990_FermentationPathwayKinetics model_entity_is "http://identifiers.org/biomodels.db/MODEL6624154196"
Galazzo1990_FermentationPathwayKinetics model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000063"
Galazzo1990_FermentationPathwayKinetics description "http://identifiers.org/doi/10.1016/0141-0229(90)90033-M"
Galazzo1990_FermentationPathwayKinetics homolog "http://identifiers.org/reactome/REACT_723"
Galazzo1990_FermentationPathwayKinetics identity "http://identifiers.org/kegg.pathway/sce00010"
Galazzo1990_FermentationPathwayKinetics hypernym "http://identifiers.org/go/GO:0019660"
Galazzo1990_FermentationPathwayKinetics property "http://identifiers.org/mamo/MAMO_0000046"
Galazzo1990_FermentationPathwayKinetics taxon "http://identifiers.org/taxonomy/4932"
Galazzo1990_FermentationPathwayKinetics part "http://identifiers.org/go/GO:0006096"
