// Created by libAntimony v2.13.0
model *Brown2004_NGF_EGF_signaling()

  // Compartments and Species:
  compartment cell;
  species EGF in cell, NGF in cell, freeEGFReceptor in cell, boundEGFReceptor in cell;
  species freeNGFReceptor in cell, boundNGFReceptor in cell, SosInactive in cell;
  species SosActive in cell, P90RskInactive in cell, P90RskActive in cell;
  species RasInactive in cell, RasActive in cell, $RasGapActive in cell, Raf1Inactive in cell;
  species Raf1Active in cell, BRafInactive in cell, BRafActive in cell, MekInactive in cell;
  species MekActive in cell, ErkInactive in cell, ErkActive in cell, PI3KInactive in cell;
  species PI3KActive in cell, AktInactive in cell, AktActive in cell, C3GInactive in cell;
  species C3GActive in cell, Rap1Inactive in cell, Rap1Active in cell, $RapGapActive in cell;
  species $PP2AActive in cell, $Raf1PPtase in cell;

  // Reactions:
  EGFBindingReaction: EGF + freeEGFReceptor => boundEGFReceptor; cell*krbEGF*EGF*freeEGFReceptor;
  EGFUnbindingReaction: boundEGFReceptor => EGF + freeEGFReceptor; cell*kruEGF*boundEGFReceptor;
  NGFBindingReaction: NGF + freeNGFReceptor => boundNGFReceptor; krbNGF*NGF*freeNGFReceptor*cell;
  NGFUnbindingReaction: boundNGFReceptor => NGF + freeNGFReceptor; kruNGF*boundNGFReceptor*cell;
  SosActivationByEGFReaction: SosInactive -> SosActive; cell*(kEGF*boundEGFReceptor*SosInactive/(SosInactive + KmEGF));
  SosActivationByNGFReaction: SosInactive -> SosActive; cell*(kNGF*boundNGFReceptor*SosInactive/(SosInactive + KmNGF));
  SosDeactivationReaction: SosActive -> SosInactive; cell*(kdSos*P90RskActive*SosActive/(SosActive + KmdSos));
  RasActivationReaction: RasInactive -> RasActive; cell*(kSos*SosActive*RasInactive/(RasInactive + KmSos));
  RasDeactivationReaction: RasActive -> RasInactive; cell*(kRasGap*RasGapActive*RasActive/(RasActive + KmRasGap));
  Raf1ByRasActivationReaction: Raf1Inactive -> Raf1Active; cell*(kRasToRaf1*RasActive*Raf1Inactive/(Raf1Inactive + KmRasToRaf1));
  MekbyRaf1ActivationReaction: MekInactive -> MekActive; cell*(kpRaf1*Raf1Active*MekInactive/(MekInactive + KmpRaf1));
  MekbyBRafActivationReaction: MekInactive -> MekActive; cell*(kpBRaf*BRafActive*MekInactive/(MekInactive + KmpBRaf));
  ErkActivationReaction: ErkInactive -> ErkActive; cell*(kpMekCytoplasmic*MekActive*ErkInactive/(ErkInactive + KmpMekCytoplasmic));
  MekDeactivationReaction: MekActive -> MekInactive; cell*(kdMek*PP2AActive*MekActive/(MekActive + KmdMek));
  ErkDeactivationReaction: ErkActive -> ErkInactive; cell*(kdErk*PP2AActive*ErkActive/(ErkActive + KmdErk));
  Raf1byPPtaseDeactivationReaction: Raf1Active -> Raf1Inactive; cell*(kdRaf1*Raf1PPtase*Raf1Active/(Raf1Active + KmdRaf1));
  P90RskActivationReaction: P90RskInactive -> P90RskActive; cell*(kpP90Rsk*ErkActive*P90RskInactive/(P90RskInactive + KmpP90Rsk));
  PI3KbyEGFRActivationReaction: PI3KInactive -> PI3KActive; cell*(kPI3K*boundEGFReceptor*PI3KInactive/(PI3KInactive + KmPI3K));
  PI3KbyRasActivationReaction: PI3KInactive -> PI3KActive; cell*(kPI3KRas*RasActive*PI3KInactive/(PI3KInactive + KmPI3KRas));
  AktActivationReaction: AktInactive -> AktActive; cell*(kAkt*PI3KActive*AktInactive/(AktInactive + KmAkt));
  Raf1ByAktDeactivationReaction: Raf1Active -> Raf1Inactive; cell*(kdRaf1ByAkt*AktActive*Raf1Active/(Raf1Active + KmRaf1ByAkt));
  C3GActivationReaction: C3GInactive -> C3GActive; cell*(kC3GNGF*boundNGFReceptor*C3GInactive/(C3GInactive + KmC3GNGF));
  Rap1ActivationReaction: Rap1Inactive -> Rap1Active; cell*(kC3G*C3GActive*Rap1Inactive/(Rap1Inactive + KmC3G));
  Rap1DeactivationReaction: Rap1Active -> Rap1Inactive; cell*(kRapGap*RapGapActive*Rap1Active/(Rap1Active + KmRapGap));
  BRafByRap1ActivationReaction: BRafInactive -> BRafActive; cell*(kRap1ToBRaf*Rap1Active*BRafInactive/(BRafInactive + KmRap1ToBRaf));
  BRafbyPPtaseDeactivationReaction: BRafActive -> BRafInactive; cell*(kdBRaf*Raf1PPtase*BRafActive/(BRafActive + KmdBRaf));

  // Species initializations:
  EGF = 10002000;
  NGF = 456000;
  freeEGFReceptor = 80000;
  boundEGFReceptor = 0;
  freeNGFReceptor = 10000;
  boundNGFReceptor = 0;
  SosInactive = 120000;
  SosActive = 0;
  P90RskInactive = 120000;
  P90RskActive = 0;
  RasInactive = 120000;
  RasActive = 0;
  RasGapActive = 120000;
  Raf1Inactive = 120000;
  Raf1Active = 0;
  BRafInactive = 120000;
  BRafActive = 0;
  MekInactive = 600000;
  MekActive = 0;
  ErkInactive = 600000;
  ErkActive = 0;
  PI3KInactive = 120000;
  PI3KActive = 0;
  AktInactive = 120000;
  AktActive = 0;
  C3GInactive = 120000;
  C3GActive = 0;
  Rap1Inactive = 120000;
  Rap1Active = 0;
  RapGapActive = 120000;
  PP2AActive = 120000;
  Raf1PPtase = 120000;

  // Compartment initializations:
  cell = 1;

  // Variable initializations:
  krbEGF = 2.18503e-05;
  kruEGF = 0.0121008;
  krbNGF = 1.38209e-07;
  kruNGF = 0.00723811;
  kEGF = 694.731;
  KmEGF = 6086070;
  kNGF = 389.428;
  KmNGF = 2112.66;
  kdSos = 1611.97;
  KmdSos = 896896;
  kSos = 32.344;
  KmSos = 35954.3;
  kRasGap = 1509.36;
  KmRasGap = 1432410;
  kRasToRaf1 = 0.884096;
  KmRasToRaf1 = 62464.6;
  kpRaf1 = 185.759;
  KmpRaf1 = 4768350;
  kpBRaf = 125.089;
  KmpBRaf = 157948;
  kdMek = 2.83243;
  KmdMek = 518753;
  kpMekCytoplasmic = 9.85367;
  KmpMekCytoplasmic = 1007340;
  kdErk = 8.8912;
  KmdErk = 3496490;
  kpP90Rsk = 0.0213697;
  KmpP90Rsk = 763523;
  kPI3K = 10.6737;
  KmPI3K = 184912;
  kPI3KRas = 0.0771067;
  KmPI3KRas = 272056;
  kAkt = 0.0566279;
  KmAkt = 653951;
  kdRaf1ByAkt = 15.1212;
  KmRaf1ByAkt = 119355;
  kC3GNGF = 146.912;
  KmC3GNGF = 12876.2;
  kC3G = 1.40145;
  KmC3G = 10965.6;
  kRapGap = 27.265;
  KmRapGap = 295990;
  kRap1ToBRaf = 2.20995;
  KmRap1ToBRaf = 1025460;
  kdRaf1 = 0.126329;
  KmdRaf1 = 1061.71;
  kdBRaf = 441.287;
  KmdBRaf = 10879500;

  // Other declarations:
  const cell, krbEGF, kruEGF, krbNGF, kruNGF, kEGF, KmEGF, kNGF, KmNGF, kdSos;
  const KmdSos, kSos, KmSos, kRasGap, KmRasGap, kRasToRaf1, KmRasToRaf1, kpRaf1;
  const KmpRaf1, kpBRaf, KmpBRaf, kdMek, KmdMek, kpMekCytoplasmic, KmpMekCytoplasmic;
  const kdErk, KmdErk, kpP90Rsk, KmpP90Rsk, kPI3K, KmPI3K, kPI3KRas, KmPI3KRas;
  const kAkt, KmAkt, kdRaf1ByAkt, KmRaf1ByAkt, kC3GNGF, KmC3GNGF, kC3G, KmC3G;
  const kRapGap, KmRapGap, kRap1ToBRaf, KmRap1ToBRaf, kdRaf1, KmdRaf1, kdBRaf;
  const KmdBRaf;

  // Unit definitions:
  unit substance = item;
  unit time_unit = 60 second;

  // Display Names:
  substance is "item (default)";
  time_unit is "minute (default)";
  EGFBindingReaction is "EGF binding";
  EGFUnbindingReaction is "EFG unbinding";
  NGFBindingReaction is "NGF binding";
  NGFUnbindingReaction is "NGF unbinding";
  SosActivationByEGFReaction is "SOS activation by EGF";
  SosActivationByNGFReaction is "SOS activation by NGF";
  SosDeactivationReaction is "SOS deactivation";
  RasActivationReaction is "Ras activation";
  RasDeactivationReaction is "Ras deactivation";
  Raf1ByRasActivationReaction is "Raf1 activation by Ras";
  MekbyRaf1ActivationReaction is "Mek activation by Raf1";
  MekbyBRafActivationReaction is "Mek activation by B-Raf";
  ErkActivationReaction is "Erk activation";
  MekDeactivationReaction is "Mek deactivation";
  ErkDeactivationReaction is "Erk deactivation";
  Raf1byPPtaseDeactivationReaction is "Raf1 deactivation by PPase";
  P90RskActivationReaction is "P90Rsk activation";
  PI3KbyEGFRActivationReaction is "PI3K activation by EGFR";
  PI3KbyRasActivationReaction is "PI3K activation by Ras";
  AktActivationReaction is "Akt activation";
  Raf1ByAktDeactivationReaction is "Raf1 deactivation by Akt";
  C3GActivationReaction is "C3G activation";
  Rap1ActivationReaction is "Rap1 activation";
  Rap1DeactivationReaction is "Rap1 deactivation";
  BRafByRap1ActivationReaction is "BRaf activation by Rap1";
  BRafbyPPtaseDeactivationReaction is "BRaf deactivation by PPase";

  // CV terms:
  cell identity "http://identifiers.org/go/GO:0005623"
  EGF identity "http://identifiers.org/uniprot/P07522"
  NGF identity "http://identifiers.org/uniprot/P25427"
  freeEGFReceptor identity "http://identifiers.org/uniprot/Q9QX70"
  boundEGFReceptor part "http://identifiers.org/uniprot/Q9QX70",
                        "http://identifiers.org/uniprot/P07522"
  freeNGFReceptor identity "http://identifiers.org/uniprot/P35739"
  boundNGFReceptor part "http://identifiers.org/uniprot/P35739",
                        "http://identifiers.org/uniprot/P25427"
  SosInactive hypernym "http://identifiers.org/ensembl/ENSRNOP00000009359",
                       "http://identifiers.org/uniprot/Q9Z1I1"
  SosActive hypernym "http://identifiers.org/ensembl/ENSRNOP00000009359",
                     "http://identifiers.org/uniprot/Q9Z1I1"
  P90RskInactive version "http://identifiers.org/uniprot/Q9Z1I2",
                         "http://identifiers.org/uniprot/Q63531"
  P90RskActive version "http://identifiers.org/uniprot/Q9Z1I2",
                       "http://identifiers.org/uniprot/Q63531"
  RasInactive hypernym "http://identifiers.org/interpro/IPR003577"
  RasActive hypernym "http://identifiers.org/interpro/IPR003577"
  RasGapActive identity "http://identifiers.org/uniprot/P50904"
  Raf1Inactive hypernym "http://identifiers.org/uniprot/P11345"
  Raf1Active hypernym "http://identifiers.org/uniprot/P11345"
  BRafInactive hypernym "http://identifiers.org/uniprot/Q99MC6"
  BRafActive hypernym "http://identifiers.org/uniprot/Q99MC6"
  MekInactive hypernym "http://identifiers.org/uniprot/Q01986",
                       "http://identifiers.org/uniprot/P36506"
  MekActive hypernym "http://identifiers.org/uniprot/Q01986",
                     "http://identifiers.org/uniprot/P36506"
  ErkInactive hypernym "http://identifiers.org/uniprot/P21708",
                       "http://identifiers.org/uniprot/P63086"
  ErkActive hypernym "http://identifiers.org/uniprot/P21708",
                     "http://identifiers.org/uniprot/P63086"
  PI3KInactive part "http://identifiers.org/interpro/IPR015433"
  PI3KInactive hypernym "http://identifiers.org/go/GO:0005942"
  PI3KActive part "http://identifiers.org/interpro/IPR015433"
  PI3KActive hypernym "http://identifiers.org/go/GO:0005942"
  AktInactive version "http://identifiers.org/uniprot/P47196",
                      "http://identifiers.org/uniprot/P47197",
                      "http://identifiers.org/uniprot/Q63484"
  AktActive version "http://identifiers.org/uniprot/P47196",
                    "http://identifiers.org/uniprot/P47197",
                    "http://identifiers.org/uniprot/Q63484"
  C3GInactive hypernym "http://identifiers.org/uniprot/Q9QYV3"
  C3GActive hypernym "http://identifiers.org/uniprot/Q9QYV3"
  Rap1Inactive version "http://identifiers.org/uniprot/P10113",
                       "http://identifiers.org/uniprot/Q62636"
  Rap1Active version "http://identifiers.org/uniprot/P10113",
                     "http://identifiers.org/uniprot/Q62636"
  RapGapActive identity "http://identifiers.org/uniprot/P47736"
  PP2AActive identity "http://identifiers.org/go/GO:0000159"
  EGFBindingReaction identity "http://identifiers.org/go/GO:0048408"
  EGFBindingReaction hypernym "http://identifiers.org/go/GO:0045741"
  EGFUnbindingReaction hypernym "http://identifiers.org/go/GO:0007175"
  NGFBindingReaction hypernym "http://identifiers.org/go/GO:0051396"
  NGFBindingReaction identity "http://identifiers.org/go/GO:0048406"
  NGFUnbindingReaction hypernym "http://identifiers.org/go/GO:0051395"
  SosActivationByEGFReaction hypernym "http://identifiers.org/ec-code/2.7.1.37",
                                      "http://identifiers.org/go/GO:0004716"
  SosActivationByNGFReaction hypernym "http://identifiers.org/ec-code/2.7.1.37",
                                      "http://identifiers.org/go/GO:0004716"
  SosDeactivationReaction hypernym "http://identifiers.org/ec-code/2.7.1.37"
  RasActivationReaction identity "http://identifiers.org/go/GO:0046579"
  RasDeactivationReaction identity "http://identifiers.org/go/GO:0046580"
  Raf1ByRasActivationReaction hypernym "http://identifiers.org/ec-code/2.7.1.37",
                                       "http://identifiers.org/go/GO:0008349",
                                       "http://identifiers.org/go/GO:0000185"
  MekbyRaf1ActivationReaction hypernym "http://identifiers.org/ec-code/2.7.1.37",
                                       "http://identifiers.org/go/GO:0004709",
                                       "http://identifiers.org/go/GO:0000186"
  MekbyBRafActivationReaction hypernym "http://identifiers.org/ec-code/2.7.1.37",
                                       "http://identifiers.org/go/GO:0004709",
                                       "http://identifiers.org/go/GO:0000186"
  ErkActivationReaction hypernym "http://identifiers.org/ec-code/2.7.1.37",
                                 "http://identifiers.org/go/GO:0000187",
                                 "http://identifiers.org/go/GO:0004708"
  MekDeactivationReaction hypernym "http://identifiers.org/ec-code/3.1.3.16"
  ErkDeactivationReaction hypernym "http://identifiers.org/ec-code/3.1.3.16",
                                   "http://identifiers.org/go/GO:0000188"
  Raf1byPPtaseDeactivationReaction hypernym "http://identifiers.org/ec-code/3.1.3.16"
  P90RskActivationReaction hypernym "http://identifiers.org/ec-code/2.7.1.37",
                                    "http://identifiers.org/go/GO:0004707"
  PI3KbyEGFRActivationReaction hypernym "http://identifiers.org/ec-code/2.7.1.37"
  PI3KbyRasActivationReaction hypernym "http://identifiers.org/ec-code/2.7.1.37",
                                       "http://identifiers.org/go/GO:0008349"
  AktActivationReaction hypernym "http://identifiers.org/go/GO:0045860"
  Raf1ByAktDeactivationReaction hypernym "http://identifiers.org/ec-code/2.7.1.37"
  C3GActivationReaction hypernym "http://identifiers.org/ec-code/2.7.1.37",
                                 "http://identifiers.org/go/GO:0004716"
  Rap1ActivationReaction identity "http://identifiers.org/go/GO:0046582"
  BRafByRap1ActivationReaction hypernym "http://identifiers.org/ec-code/2.7.1.37",
                                        "http://identifiers.org/go/GO:0000185"
  BRafbyPPtaseDeactivationReaction hypernym "http://identifiers.org/ec-code/3.1.3.16"
end

Brown2004_NGF_EGF_signaling is "Brown2004 - NGF and EGF signaling"

Brown2004_NGF_EGF_signaling model_entity_is "http://identifiers.org/biomodels.db/MODEL6619514794"
Brown2004_NGF_EGF_signaling model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000033"
Brown2004_NGF_EGF_signaling description "http://identifiers.org/pubmed/16204838"
Brown2004_NGF_EGF_signaling hypernym "http://identifiers.org/go/GO:0070371"
Brown2004_NGF_EGF_signaling taxon "http://identifiers.org/taxonomy/131567"
Brown2004_NGF_EGF_signaling property "http://identifiers.org/mamo/MAMO_0000046"
Brown2004_NGF_EGF_signaling part "http://identifiers.org/go/GO:0048011",
                                 "http://identifiers.org/go/GO:0007173"
