// Created by libAntimony v2.13.0
model *model_0000001()

  // Compartments and Species:
  compartment cell;
  species M in cell, MpY in cell, MpT in cell, Mpp in cell, $MEK in cell;
  species $MKP3 in cell;

  // Reactions:
  v1: M => MpY; cell*(kcat1*MEK*M/Km1/(1 + M*((Km1 + Km3)/(Km1*Km3)) + MpY/Km2 + MpT/Km4));
  v2: MpY => Mpp; cell*(kcat2*MEK*MpY/Km2/(1 + M*((Km1 + Km3)/(Km1*Km3)) + MpY/Km2 + MpT/Km4));
  v3: M => MpT; cell*(kcat3*MEK*M/Km3/(1 + M*((Km1 + Km3)/(Km1*Km3)) + MpY/Km2 + MpT/Km4));
  v4: MpT => Mpp; cell*(kcat4*MEK*MpT/Km4/(1 + M*((Km1 + Km3)/(Km1*Km3)) + MpY/Km2 + MpT/Km4));
  v5: Mpp => MpT; cell*(kcat5*MKP3*Mpp/Km5/(1 + Mpp/Km5 + MpT/Km6 + MpY/Km7 + M/Km8));
  v6: MpT => M; cell*(kcat6*MKP3*MpT/Km6/(1 + Mpp/Km5 + MpT/Km6 + MpY/Km7 + M/Km8));
  v7: MpY => M; cell*(kcat7*MKP3*MpY/Km7/(1 + Mpp/Km5 + MpT/Km6 + MpY/Km7 + M/Km8));

  // Species initializations:
  M = 800;
  MpY = 0;
  MpT = 0;
  Mpp = 0;
  MEK = 180;
  MKP3 = 100;

  // Compartment initializations:
  cell = 1;

  // Variable initializations:
  Km1 = 410;
  kcat1 = 1.08;
  Km2 = 40;
  kcat2 = 0.007;
  Km3 = 20;
  kcat3 = 0.008;
  Km4 = 300;
  kcat4 = 0.45;
  Km5 = 22;
  kcat5 = 0.084;
  Km6 = 18;
  kcat6 = 0.06;
  Km7 = 34;
  kcat7 = 0.108;
  Km8 = 40;

  // Other declarations:
  const cell, Km1, kcat1, Km2, kcat2, Km3, kcat3, Km4, kcat4, Km5, kcat5;
  const Km6, kcat6, Km7, kcat7, Km8;

  // Unit definitions:
  unit substance = 1e-9 mole;

  // Display Names:
  substance is "nanomole (default)";
  M is "ERK";
  MpY is "ERK-PY";
  MpT is "ERK-PT";
  Mpp is "ERK-PP";
  v1 is "phosphorylation of ERK on Tyr";
  v2 is "phosphorylation of ERK-PY on Thr";
  v3 is "phosphorylation of ERK on Thr";
  v4 is "phosphorylation of ERK-PT on Tyr";
  v5 is "dephosphorylation of ERK-PP on Tyr";
  v6 is "dephosphorylation of ERK-PT";
  v7 is "dephosphorylation of ERK-PY";

  // CV terms:
  cell identity "http://identifiers.org/obo.go/GO:0005623"
  M hypernym "http://identifiers.org/uniprot/P26696"
  MpY hypernym "http://identifiers.org/uniprot/P26696"
  MpT hypernym "http://identifiers.org/uniprot/P26696"
  Mpp hypernym "http://identifiers.org/uniprot/P26696"
  MEK identity "http://identifiers.org/uniprot/Q05116"
  MKP3 identity "http://identifiers.org/uniprot/Q90W58"
  v1 hypernym "http://identifiers.org/ec-code/2.7.12.2",
              "http://identifiers.org/obo.go/GO:0018108",
              "http://identifiers.org/obo.go/GO:0004708"
  v1 homolog "http://identifiers.org/reactome/REACT_2247",
             "http://identifiers.org/reactome/REACT_136"
  v2 homolog "http://identifiers.org/reactome/REACT_2247",
             "http://identifiers.org/reactome/REACT_136"
  v2 hypernym "http://identifiers.org/ec-code/2.7.12.2",
              "http://identifiers.org/obo.go/GO:0018107",
              "http://identifiers.org/obo.go/GO:0000187",
              "http://identifiers.org/obo.go/GO:0004708"
  v3 hypernym "http://identifiers.org/ec-code/2.7.12.2",
              "http://identifiers.org/obo.go/GO:0018107",
              "http://identifiers.org/obo.go/GO:0004708"
  v3 homolog "http://identifiers.org/reactome/REACT_2247",
             "http://identifiers.org/reactome/REACT_136"
  v4 homolog "http://identifiers.org/reactome/REACT_2247",
             "http://identifiers.org/reactome/REACT_136"
  v4 hypernym "http://identifiers.org/ec-code/2.7.12.2",
              "http://identifiers.org/obo.go/GO:0004708",
              "http://identifiers.org/obo.go/GO:0000187",
              "http://identifiers.org/obo.go/GO:0018108"
  v5 hypernym "http://identifiers.org/ec-code/3.1.3.16",
              "http://identifiers.org/obo.go/GO:0000188",
              "http://identifiers.org/obo.go/GO:0006470"
  v6 hypernym "http://identifiers.org/ec-code/3.1.3.16",
              "http://identifiers.org/obo.go/GO:0006470"
  v7 hypernym "http://identifiers.org/ec-code/3.1.3.16",
              "http://identifiers.org/obo.go/GO:0006470"
end

model_0000001 is "Markevich2004_MAPK_phosphoRandomMM"

model_0000001 model_entity_is "http://identifiers.org/biomodels.db/MODEL6618620128"
model_0000001 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000029"
model_0000001 description "http://identifiers.org/pubmed/14744999"
model_0000001 hypernym "http://identifiers.org/obo.go/GO:0000165"
model_0000001 taxon "http://identifiers.org/taxonomy/8355"
