// Created by libAntimony v2.13.0
model *Markevich2004_MAPK_orderedelementary()

  // Compartments and Species:
  compartment uVol;
  species M in uVol, Mp in uVol, Mpp in uVol, MAPKK in uVol, MKP3 in uVol;
  species M_MAPKK in uVol, Mp_MAPKK in uVol, Mpp_MKP3 in uVol, Mp_MKP3_dep in uVol;
  species Mp_MKP3 in uVol, M_MKP3 in uVol;

  // Reactions:
  v1a: M + MAPKK -> M_MAPKK; uVol*(k1*M*MAPKK - k_1*M_MAPKK);
  v1b: M_MAPKK => Mp + MAPKK; uVol*k2*M_MAPKK;
  v2a: Mp + MAPKK -> Mp_MAPKK; uVol*(k3*Mp*MAPKK - k_3*Mp_MAPKK);
  v2b: Mp_MAPKK => Mpp + MAPKK; uVol*k4*Mp_MAPKK;
  v3a: Mpp + MKP3 -> Mpp_MKP3; uVol*(h1*Mpp*MKP3 - h_1*Mpp_MKP3);
  v3b: Mpp_MKP3 => Mp_MKP3_dep; uVol*h2*Mpp_MKP3;
  v3c: Mp_MKP3_dep -> Mp + MKP3; h3*Mp_MKP3_dep - h_3*Mp*MKP3;
  v4a: Mp + MKP3 -> Mp_MKP3; uVol*(h4*Mp*MKP3 - h_4*Mp_MKP3);
  v4b: Mp_MKP3 => M_MKP3; uVol*h5*Mp_MKP3;
  v4c: M_MKP3 -> M + MKP3; uVol*(h6*M_MKP3 - h_6*M*MKP3);

  // Species initializations:
  M = 500/uVol;
  Mp = 0;
  Mpp = 0;
  MAPKK = 50/uVol;
  MKP3 = 100/uVol;
  M_MAPKK = 0;
  Mp_MAPKK = 0;
  Mpp_MKP3 = 0;
  Mp_MKP3_dep = 0;
  Mp_MKP3 = 0;
  M_MKP3 = 0;

  // Compartment initializations:
  uVol = 1;

  // Variable initializations:
  k1 = 0.02;
  k_1 = 1;
  k2 = 0.01;
  k3 = 0.032;
  k_3 = 1;
  k4 = 15;
  h1 = 0.045;
  h_1 = 1;
  h2 = 0.092;
  h3 = 1;
  h_3 = 0.01;
  h4 = 0.01;
  h_4 = 1;
  h5 = 0.5;
  h6 = 0.086;
  h_6 = 0.0011;

  // Other declarations:
  const uVol, k1, k_1, k2, k3, k_3, k4, h1, h_1, h2, h3, h_3, h4, h_4, h5;
  const h6, h_6;

  // Unit definitions:
  unit substance = 1e-9 mole;

  // Display Names:
  substance is "nanomole (default)";
  MKP3 is "MKP";
  Mpp_MKP3 is "Mpp_MKP";
  Mp_MKP3_dep is "Mp_MKP";
  Mp_MKP3 is "Mp_MKP*";
  M_MKP3 is "M_MKP";
  v1a is "binding MAPK and PP-MAPKK";
  v1b is "phosphorylation of MAPK";
  v2a is "binding PP-MAPKK and P-MAPK";
  v2b is "phosphorylation of P-MAPK";
  v3a is "binding MKP and PP-MAPK";
  v3b is "dephosphorylation of PP-MAPK";
  v3c is "dissociation of MKP from P-MAPK";
  v4a is "binding MKP and P-MAPK";
  v4b is "dephosphorylation of P-MAPK";
  v4c is "dissociation of MKP from MAPK";

  // CV terms:
  M hypernym "http://identifiers.org/uniprot/P26696"
  Mp hypernym "http://identifiers.org/uniprot/P26696"
  Mpp hypernym "http://identifiers.org/uniprot/P26696"
  MAPKK identity "http://identifiers.org/uniprot/Q05116"
  MKP3 identity "http://identifiers.org/uniprot/Q90W58"
  M_MAPKK part "http://identifiers.org/uniprot/P26696",
               "http://identifiers.org/uniprot/Q05116"
  Mp_MAPKK part "http://identifiers.org/uniprot/Q05116",
                "http://identifiers.org/uniprot/P26696"
  Mpp_MKP3 part "http://identifiers.org/uniprot/Q90W58",
                "http://identifiers.org/uniprot/P26696"
  Mp_MKP3_dep part "http://identifiers.org/uniprot/Q90W58",
                   "http://identifiers.org/uniprot/P26696"
  Mp_MKP3 part "http://identifiers.org/uniprot/Q90W58",
               "http://identifiers.org/uniprot/P26696"
  M_MKP3 part "http://identifiers.org/uniprot/Q90W58",
              "http://identifiers.org/uniprot/P26696"
  v1a hypernym "http://identifiers.org/obo.go/GO:0031434",
               "http://identifiers.org/obo.go/GO:0051019"
  v1a homolog "http://identifiers.org/reactome/REACT_1780",
              "http://identifiers.org/reactome/REACT_495"
  v1b hypernym "http://identifiers.org/ec-code/2.7.12.2",
               "http://identifiers.org/obo.go/GO:0006468",
               "http://identifiers.org/obo.go/GO:0004708"
  v1b homolog "http://identifiers.org/reactome/REACT_136",
              "http://identifiers.org/reactome/REACT_2247"
  v2a hypernym "http://identifiers.org/obo.go/GO:0031434",
               "http://identifiers.org/obo.go/GO:0051019"
  v2a homolog "http://identifiers.org/reactome/REACT_1780",
              "http://identifiers.org/reactome/REACT_495"
  v2b hypernym "http://identifiers.org/ec-code/2.7.12.2",
               "http://identifiers.org/obo.go/GO:0000187",
               "http://identifiers.org/obo.go/GO:0006468",
               "http://identifiers.org/obo.go/GO:0004708"
  v2b homolog "http://identifiers.org/reactome/REACT_136",
              "http://identifiers.org/reactome/REACT_2247"
  v3a hypernym "http://identifiers.org/obo.go/GO:0031434",
               "http://identifiers.org/obo.go/GO:0051019"
  v3b hypernym "http://identifiers.org/ec-code/3.1.3.16",
               "http://identifiers.org/obo.go/GO:0000188",
               "http://identifiers.org/obo.go/GO:0006470"
  v3c hypernym "http://identifiers.org/obo.go/GO:0043241"
  v4a hypernym "http://identifiers.org/obo.go/GO:0051019"
  v4b hypernym "http://identifiers.org/ec-code/3.1.3.16"
  v4c hypernym "http://identifiers.org/obo.go/GO:0043241"
end

Markevich2004_MAPK_orderedelementary is "Markevich2004_MAPK_orderedElementary"

Markevich2004_MAPK_orderedelementary model_entity_is "http://identifiers.org/biomodels.db/MODEL6618379269"
Markevich2004_MAPK_orderedelementary model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000026"
Markevich2004_MAPK_orderedelementary description "http://identifiers.org/pubmed/14744999"
Markevich2004_MAPK_orderedelementary taxon "http://identifiers.org/taxonomy/8355"
Markevich2004_MAPK_orderedelementary hypernym "http://identifiers.org/obo.go/GO:0000165"
