// Created by libAntimony v2.13.0
model *MorrisonAllegra()

  // Compartments and Species:
  compartment ext_, cell;
  species FH2f in cell, $FH2b in cell, DHFRf in cell, $DHFRtot in cell, MTX1b in cell;
  species MTX2b in cell, MTX3b in cell, MTX4b in cell, MTX5b in cell, FH4 in cell;
  species CH2FH4 in cell, CH3FH4 in cell, CHOFH4 in cell, FFH2 in cell, HCHO in cell;
  species FGAR in cell, AICAR in cell, MTX1 in cell, MTX2 in cell, MTX3 in cell;
  species MTX4 in cell, MTX5 in cell, $EMTX in ext_, $dUMP in cell, $GAR in cell;
  species $serine in cell, $formate in cell, $ATP in cell, $glutamine in cell;
  species $glycine in cell, $NADP in cell, $NADPH in cell, $homocysteine in cell;

  // Assignment Rules:
  FH2b := FH2f*DHFRf/Keq;
  DHFRtot := FH2b + DHFRf + MTX1b + MTX2b + MTX3b + MTX4b + MTX5b;

  // Reactions:
  SHMT: FH4 + $serine => CH2FH4; cell*(SHMT_Vm*(serine/SHMT_Km2/(1 + serine/SHMT_Km2))*(FH4/SHMT_Km1)/(1 + FH4/SHMT_Km1));
  SHMTr: CH2FH4 => FH4; cell*(SHMTr_Vm*(glycine/SHMTr_Km2/(1 + glycine/SHMTr_Km2))*(CH2FH4/SHMTr_Km1)/(1 + CH2FH4/SHMTr_Km1));
  HCHOtoCH2FH4: FH4 + HCHO => CH2FH4; cell*HCHOtoCH2FH4_hp*FH4*HCHO;
  CH2FH4toHCHO: CH2FH4 => FH4 + HCHO; cell*CH2FH4toHCHO_hl*CH2FH4;
  MTHFR: CH2FH4 + $NADPH => CH3FH4; cell*(MTHFR_Vm*CH2FH4*NADPH/(NADPH*CH2FH4 + CH2FH4*MTHFR_Km2 + (NADPH + MTHFR_Km2)*MTHFR_Km1*(1 + MTX1/MTHFR_Ki21 + MTX2/MTHFR_Ki22 + MTX3/MTHFR_Ki23 + MTX4/MTHFR_Ki24 + MTX5/MTHFR_Ki25 + FH2f/MTHFR_Ki1)));
  MTR: CH3FH4 + $homocysteine => FH4; cell*(MTR_Vm*(homocysteine/MTR_Km2/(1 + homocysteine/MTR_Km2))*(CH3FH4/MTR_Km1)/(1 + CH3FH4/MTR_Km1));
  HCOOHtoCHOFH4: FH4 + $formate + $ATP => CHOFH4; cell*(HCOOHtoCHOFH4_Vm/((1 + HCOOHtoCHOFH4_Km1/FH4)*(1 + HCOOHtoCHOFH4_Km2/ATP)*(1 + HCOOHtoCHOFH4_Km3/formate)));
  GARFT: CHOFH4 + $GAR => FGAR + FH4; cell*(GARFT_Vm*CHOFH4*GAR/(GAR*CHOFH4 + CHOFH4*GARFT_Km2 + (GAR + GARFT_Km2)*GARFT_Km1*(1 + MTX1/GARFT_Ki21 + MTX2/GARFT_Ki22 + MTX3/GARFT_Ki23 + MTX4/GARFT_Ki24 + MTX5/GARFT_Ki25 + FH2f/GARFT_Ki1 + FFH2/GARFT_Ki1f)));
  ATIC7: CHOFH4 + AICAR => FH4; cell*(ATIC7_Vm*CHOFH4*AICAR/(AICAR*CHOFH4 + CHOFH4*ATIC7_Km2 + (AICAR + ATIC7_Km2)*ATIC7_Km1*(1 + MTX1/ATIC7_Ki21 + MTX2/ATIC7_Ki22 + MTX3/ATIC7_Ki23 + MTX4/ATIC7_Ki24 + MTX5/ATIC7_Ki25 + FH2f/ATIC7_Ki1 + FFH2/ATIC7_Ki1f)));
  MTHFD: CH2FH4 + $NADP => CHOFH4; cell*MTHFD_Vm*(CH2FH4/MTHFD_Km1/(1 + CH2FH4/MTHFD_Km1))*(NADP/MTHFD_Km2/(1 + NADP/MTHFD_Km2));
  TYMS: CH2FH4 + $dUMP => FH2f; cell*(TYMS_Vm*CH2FH4*dUMP/(dUMP*CH2FH4*(1 + MTX1/TYMS_Ki21 + MTX2/TYMS_Ki22 + MTX3/TYMS_Ki23 + MTX4/TYMS_Ki24 + MTX5/TYMS_Ki25 + FH2f/TYMS_Ki1) + TYMS_Km1*dUMP*((FFH2/TYMS_Ki1f)*(MTX1/TYMS_Ki21) + (1 + FFH2/TYMS_Ki1f)*(1 + MTX2/TYMS_Ki22 + MTX3/TYMS_Ki23 + MTX4/TYMS_Ki24 + MTX5/TYMS_Ki25 + FH2f/TYMS_Ki1)) + TYMS_Km1*TYMS_Km2*(1 + MTX2/TYMS_Ki22 + MTX3/TYMS_Ki23 + MTX4/TYMS_Ki24 + MTX5/TYMS_Ki25 + FH2f/TYMS_Ki1)));
  DHFReductase: FH2f => FH4; cell*DHFReductase_kter*FH2b;
  FFH2syn: FH2f => FFH2; cell*FFH2syn_Vm*FH2f;
  ATIC12: FFH2 + AICAR => FH2f; cell*(ATIC12_Vm*FFH2*AICAR/(AICAR*FFH2 + FFH2*ATIC12_Km2 + (AICAR + ATIC12_Km2)*ATIC12_Km1*(1 + MTX1/ATIC12_Ki21 + MTX2/ATIC12_Ki22 + MTX3/ATIC12_Ki23 + MTX4/ATIC12_Ki24 + MTX5/ATIC12_Ki25 + FH2f/ATIC12_Ki1 + FFH2/ATIC12_Ki1f)));
  AICARsyn: FGAR => AICAR; cell*AICARsyn_Vm*(glutamine/AICARsyn_Km1/(1 + glutamine/AICARsyn_Km1))*(FGAR/AICARsyn_Km2/(1 + FGAR/AICARsyn_Km2));
  FPGS12: MTX1 => MTX2; cell*FPGS12_Vm*MTX1;
  FPGS23: MTX2 => MTX3; cell*FPGS23_Vm*MTX2;
  FPGS34: MTX3 => MTX4; cell*FPGS34_Vm*MTX3;
  FPGS45: MTX4 => MTX5; cell*FPGS45_Vm*MTX4;
  GGH21: MTX2 => MTX1; cell*GGH21_Vm*MTX2;
  GGH32: MTX3 => MTX2; cell*GGH32_Vm*MTX3;
  GGH43: MTX4 => MTX3; cell*GGH43_Vm*MTX4;
  GGH54: MTX5 => MTX4; cell*GGH54_Vm*MTX5;
  RFC: $EMTX => MTX1; ext_*(RFC_Vm*EMTX/(RFC_Km + EMTX));
  MTX1export: MTX1 => ; cell*MTX1export_Vm*MTX1;
  MTX2export: MTX2 => ; cell*MTX2export_Vm*MTX2;
  MTX3export: MTX3 => ; cell*MTX3export_Vm*MTX3;
  MTX4export: MTX4 => ; cell*MTX4export_Vm*MTX4;
  MTX5export: MTX5 => ; cell*MTX5export_Vm*MTX5;
  MTX1on: MTX1 + DHFRf => MTX1b; cell*MTX1on_Vm*DHFRf*MTX1;
  MTX2on: MTX2 + DHFRf => MTX2b; cell*MTX2on_Vm*DHFRf*MTX2;
  MTX3on: MTX3 + DHFRf => MTX3b; cell*MTX3on_Vm*DHFRf*MTX3;
  MTX4on: MTX4 + DHFRf => MTX4b; cell*MTX4on_Vm*DHFRf*MTX4;
  MTX5on: MTX5 + DHFRf => MTX5b; cell*MTX5on_Vm*DHFRf*MTX5;
  MTX1off: MTX1b => MTX1 + DHFRf; cell*MTX1off_Vm*MTX1b;
  MTX2off: MTX2b => MTX2 + DHFRf; cell*MTX2off_Vm*MTX2b;
  MTX3off: MTX3b => MTX3 + DHFRf; cell*MTX3off_Vm*MTX3b;
  MTX4off: MTX4b => MTX4 + DHFRf; cell*MTX4off_Vm*MTX4b;
  MTX5off: MTX5b => MTX5 + DHFRf; cell*MTX5off_Vm*MTX5b;
  DHFRfsyn:  => DHFRf; cell*(DHFRfsyn_k0 + DHFRfsyn_k1*EMTX);
  DHFRdeg: DHFRf => ; DHFRdeg_Vm*cell*(DHFRf + FH2b);
  FH2bdeg:  => FH2f; cell*FH2bdeg_Vm*FH2b;
  MTX1deg: MTX1b => MTX1; cell*MTX1deg_Vm*MTX1b;
  MTX2deg: MTX2b => MTX2; cell*MTX2deg_Vm*MTX2b;
  MTX3deg: MTX3b => MTX3; cell*MTX3deg_Vm*MTX3b;
  MTX4deg: MTX4b => MTX4; cell*MTX4deg_Vm*MTX4b;
  MTX5deg: MTX5b => MTX5; cell*MTX5deg_Vm*MTX5b;

  // Species initializations:
  FH2f = 0.0012;
  DHFRf = 0.64;
  MTX1b = 0;
  MTX2b = 0;
  MTX3b = 0;
  MTX4b = 0;
  MTX5b = 0;
  FH4 = 0.46;
  CH2FH4 = 0.26;
  CH3FH4 = 1.63;
  CHOFH4 = 1;
  FFH2 = 0.000332;
  HCHO = 0.0074;
  FGAR = 16.49;
  AICAR = 3.695;
  MTX1 = 0;
  MTX2 = 0;
  MTX3 = 0;
  MTX4 = 0;
  MTX5 = 0;
  EMTX = 0;
  dUMP = 20.76;
  GAR = 689.6;
  serine = 123.3;
  formate = 500;
  ATP = 2980;
  glutamine = 7170;
  glycine = 1600;
  NADP = 6.73;
  NADPH = 294;
  homocysteine = 10;

  // Compartment initializations:
  ext_ = 1;
  cell = 1;

  // Variable initializations:
  Keq = 0.32;
  SHMT_Vm = 18330;
  SHMT_Km1 = 1.7;
  SHMT_Km2 = 210;
  SHMTr_Vm = 12200000;
  SHMTr_Km1 = 3200;
  SHMTr_Km2 = 10000;
  HCHOtoCH2FH4_hp = 23.2;
  CH2FH4toHCHO_hl = 0.3;
  MTHFR_Vm = 224.8;
  MTHFR_Km1 = 50;
  MTHFR_Km2 = 50;
  MTHFR_Ki1 = 0.4;
  MTHFR_Ki21 = 59;
  MTHFR_Ki22 = 21.3;
  MTHFR_Ki23 = 7.68;
  MTHFR_Ki24 = 2.77;
  MTHFR_Ki25 = 1;
  MTR_Vm = 22600;
  MTR_Km1 = 125;
  MTR_Km2 = 2900;
  HCOOHtoCHOFH4_Vm = 3600;
  HCOOHtoCHOFH4_Km1 = 230;
  HCOOHtoCHOFH4_Km2 = 56;
  HCOOHtoCHOFH4_Km3 = 1600;
  GARFT_Vm = 4126;
  GARFT_Km1 = 4.9;
  GARFT_Km2 = 52;
  GARFT_Ki1 = 5;
  GARFT_Ki1f = 1;
  GARFT_Ki21 = 84;
  GARFT_Ki22 = 60;
  GARFT_Ki23 = 43;
  GARFT_Ki24 = 31;
  GARFT_Ki25 = 22;
  ATIC7_Vm = 31675;
  ATIC7_Km1 = 5.5;
  ATIC7_Km2 = 24;
  ATIC7_Ki1 = 2.89;
  ATIC7_Ki1f = 5.3;
  ATIC7_Ki21 = 40;
  ATIC7_Ki22 = 31.5;
  ATIC7_Ki23 = 2.33;
  ATIC7_Ki24 = 3.61;
  ATIC7_Ki25 = 5.89;
  MTHFD_Vm = 68500;
  MTHFD_Km1 = 3;
  MTHFD_Km2 = 21.8;
  TYMS_Vm = 58;
  TYMS_Km1 = 2.5;
  TYMS_Km2 = 1.8;
  TYMS_Ki1 = 3;
  TYMS_Ki1f = 1.6;
  TYMS_Ki21 = 13;
  TYMS_Ki22 = 0.08;
  TYMS_Ki23 = 0.07;
  TYMS_Ki24 = 0.065;
  TYMS_Ki25 = 0.047;
  DHFReductase_kter = 2109.4;
  FFH2syn_Vm = 65;
  ATIC12_Vm = 9503;
  ATIC12_Km1 = 5.3;
  ATIC12_Km2 = 24;
  ATIC12_Ki1 = 2.89;
  ATIC12_Ki1f = 5.5;
  ATIC12_Ki21 = 40;
  ATIC12_Ki22 = 31.5;
  ATIC12_Ki23 = 2.33;
  ATIC12_Ki24 = 3.61;
  ATIC12_Ki25 = 5.89;
  AICARsyn_Vm = 4656;
  AICARsyn_Km1 = 100;
  AICARsyn_Km2 = 100;
  FPGS12_Vm = 0.129;
  FPGS23_Vm = 0.369;
  FPGS34_Vm = 0.118;
  FPGS45_Vm = 0.185;
  GGH21_Vm = 0.195;
  GGH32_Vm = 0.025;
  GGH43_Vm = 0.031;
  GGH54_Vm = 0.191;
  RFC_Vm = 82.2;
  RFC_Km = 8.2;
  MTX1export_Vm = 4.65;
  MTX2export_Vm = 0;
  MTX3export_Vm = 0.063;
  MTX4export_Vm = 0.063;
  MTX5export_Vm = 0.063;
  MTX1on_Vm = 23100;
  MTX2on_Vm = 44300;
  MTX3on_Vm = 85100;
  MTX4on_Vm = 163000;
  MTX5on_Vm = 314000;
  MTX1off_Vm = 0.42;
  MTX2off_Vm = 0.42;
  MTX3off_Vm = 0.42;
  MTX4off_Vm = 0.42;
  MTX5off_Vm = 0.42;
  DHFRfsyn_k0 = 0.0192;
  DHFRfsyn_k1 = 0.04416;
  DHFRdeg_Vm = 0.03;
  FH2bdeg_Vm = 0.03;
  MTX1deg_Vm = 0.03;
  MTX2deg_Vm = 0.03;
  MTX3deg_Vm = 0.03;
  MTX4deg_Vm = 0.03;
  MTX5deg_Vm = 0.03;

  // Other declarations:
  const ext_, cell, Keq;

  // Unit definitions:
  unit substance = 1e-6 mole;
  unit time_unit = 3600 second;

  // Display Names:
  substance is "micromole (new default)";
  time_unit is "heure (new default)";
  FH2f is "dihydrofolate free";
  FH2b is "dihydrofolate bound";
  DHFRf is "dihydrofolate reductase free";
  DHFRtot is "dihydrofolate reductase total";
  FH4 is "tetrahydrofolate";
  CH2FH4 is "5,10-methylene-tetrahydrofolate";
  CH3FH4 is "5-methyl-tetrahydrofolate";
  CHOFH4 is "10-formyl-tetrahydrofolate";
  FFH2 is "10-formyl-dihydrofolate";

  // CV terms:
  ext_ identity "http://identifiers.org/go/GO:0005615"
  cell identity "http://identifiers.org/go/GO:0005623"
  FH2f hypernym "http://identifiers.org/chebi/CHEBI:15633",
                "http://identifiers.org/kegg.compound/C00415"
  FH2b hypernym "http://identifiers.org/chebi/CHEBI:15633",
                "http://identifiers.org/kegg.compound/C00415"
  DHFRf identity "http://identifiers.org/uniprot/P00374"
  DHFRtot identity "http://identifiers.org/uniprot/P00374"
  MTX1b identity "http://identifiers.org/kegg.compound/C01937"
  MTX2b identity "http://identifiers.org/kegg.compound/C01937"
  MTX3b identity "http://identifiers.org/kegg.compound/C01937"
  MTX4b identity "http://identifiers.org/kegg.compound/C01937"
  MTX5b identity "http://identifiers.org/kegg.compound/C01937"
  FH4 identity "http://identifiers.org/chebi/CHEBI:20506",
               "http://identifiers.org/kegg.compound/C00101"
  CH2FH4 identity "http://identifiers.org/chebi/CHEBI:15636",
                  "http://identifiers.org/kegg.compound/C00143"
  CH3FH4 identity "http://identifiers.org/chebi/CHEBI:15641",
                  "http://identifiers.org/kegg.compound/C00440"
  CHOFH4 identity "http://identifiers.org/chebi/CHEBI:15637",
                  "http://identifiers.org/kegg.compound/C00234"
  FFH2 identity "http://identifiers.org/chebi/CHEBI:15634",
                "http://identifiers.org/kegg.compound/C03204"
  HCHO identity "http://identifiers.org/chebi/CHEBI:16842",
                "http://identifiers.org/kegg.compound/C00067"
  FGAR identity "http://identifiers.org/kegg.compound/C04376"
  AICAR identity "http://identifiers.org/chebi/CHEBI:18406",
                 "http://identifiers.org/kegg.compound/C04677"
  MTX1 identity "http://identifiers.org/kegg.compound/C01937"
  MTX2 identity "http://identifiers.org/kegg.compound/C01937"
  MTX3 identity "http://identifiers.org/kegg.compound/C01937"
  MTX4 identity "http://identifiers.org/kegg.compound/C01937"
  MTX5 identity "http://identifiers.org/kegg.compound/C01937"
  EMTX identity "http://identifiers.org/kegg.compound/C01937"
  dUMP identity "http://identifiers.org/chebi/CHEBI:17622",
                "http://identifiers.org/kegg.compound/C00365"
  GAR identity "http://identifiers.org/kegg.compound/C03838"
  serine identity "http://identifiers.org/chebi/CHEBI:17115",
                  "http://identifiers.org/kegg.compound/C00065"
  formate identity "http://identifiers.org/chebi/CHEBI:15740",
                   "http://identifiers.org/kegg.compound/C00058"
  ATP identity "http://identifiers.org/chebi/CHEBI:15422",
               "http://identifiers.org/kegg.compound/C00002"
  glutamine identity "http://identifiers.org/chebi/CHEBI:18050",
                     "http://identifiers.org/kegg.compound/C00064"
  glycine identity "http://identifiers.org/chebi/CHEBI:15428",
                   "http://identifiers.org/kegg.compound/C00037"
  NADP identity "http://identifiers.org/chebi/CHEBI:18009",
                "http://identifiers.org/kegg.compound/C00006"
  NADPH identity "http://identifiers.org/chebi/CHEBI:16474",
                 "http://identifiers.org/kegg.compound/C00005"
  homocysteine identity "http://identifiers.org/chebi/CHEBI:17230",
                        "http://identifiers.org/kegg.compound/C05330"
  SHMT identity "http://identifiers.org/kegg.reaction/R00945"
  SHMT hypernym "http://identifiers.org/ec-code/2.1.2.1"
  SHMTr identity "http://identifiers.org/kegg.reaction/R00945"
  SHMTr hypernym "http://identifiers.org/ec-code/2.1.2.1"
  MTHFR identity "http://identifiers.org/kegg.reaction/R01224"
  MTHFR hypernym "http://identifiers.org/ec-code/1.5.1.20"
  MTR identity "http://identifiers.org/kegg.reaction/R00946"
  MTR hypernym "http://identifiers.org/ec-code/2.1.1.13"
  HCOOHtoCHOFH4 identity "http://identifiers.org/kegg.reaction/R00943"
  HCOOHtoCHOFH4 hypernym "http://identifiers.org/ec-code/6.3.4.3"
  GARFT identity "http://identifiers.org/kegg.reaction/R04325",
                 "http://identifiers.org/reactome/REACT_1509"
  GARFT hypernym "http://identifiers.org/ec-code/2.1.2.2"
  ATIC7 identity "http://identifiers.org/kegg.reaction/R04560",
                 "http://identifiers.org/reactome/REACT_812"
  ATIC7 hypernym "http://identifiers.org/ec-code/2.1.2.3"
  MTHFD part "http://identifiers.org/ec-code/1.5.1.5",
             "http://identifiers.org/ec-code/6.3.4.3",
             "http://identifiers.org/kegg.reaction/R01220",
             "http://identifiers.org/kegg.reaction/R01655"
  TYMS identity "http://identifiers.org/kegg.reaction/R02101"
  TYMS hypernym "http://identifiers.org/ec-code/2.1.1.45"
  DHFReductase identity "http://identifiers.org/kegg.reaction/R00939"
  DHFReductase hypernym "http://identifiers.org/ec-code/1.5.1.3"
  FFH2syn identity "http://identifiers.org/kegg.reaction/R02238"
  FFH2syn hypernym "http://identifiers.org/ec-code/6.3.4.17"
  ATIC12 hypernym "http://identifiers.org/ec-code/2.1.2.3"
  ATIC12 identity "http://identifiers.org/kegg.reaction/R04560"
  AICARsyn hypernym "http://identifiers.org/ec-code/6.3.5.3"
  FPGS12 hypernym "http://identifiers.org/ec-code/6.3.2.17"
  FPGS23 hypernym "http://identifiers.org/ec-code/6.3.2.17"
  FPGS34 hypernym "http://identifiers.org/ec-code/6.3.2.17"
  FPGS45 hypernym "http://identifiers.org/ec-code/6.3.2.17"
  GGH21 hypernym "http://identifiers.org/ec-code/3.4.19.9"
  GGH32 hypernym "http://identifiers.org/ec-code/3.4.19.9"
  GGH43 identity "http://identifiers.org/ec-code/3.4.19.9"
  GGH54 identity "http://identifiers.org/ec-code/3.4.19.9"
  RFC identity "http://identifiers.org/go/GO:0008517"
  MTX1export identity "http://identifiers.org/go/GO:0008517"
  MTX2export identity "http://identifiers.org/go/GO:0008517"
  MTX3export identity "http://identifiers.org/go/GO:0008517"
  MTX4export hypernym "http://identifiers.org/go/GO:0008517"
  MTX5export hypernym "http://identifiers.org/go/GO:0008517"
end

MorrisonAllegra is "Morrison1989 - Folate Cycle"

MorrisonAllegra model_entity_is "http://identifiers.org/biomodels.db/MODEL6617317313"
MorrisonAllegra model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000018"
MorrisonAllegra description "http://identifiers.org/pubmed/2732237"
MorrisonAllegra taxon "http://identifiers.org/taxonomy/9606"
MorrisonAllegra part "http://identifiers.org/kegg.pathway/map00670",
                     "http://identifiers.org/kegg.pathway/map00790"
MorrisonAllegra hypernym "http://identifiers.org/go/GO:0046655"
MorrisonAllegra property "http://identifiers.org/doid/DOID:1612"
