// Created by libAntimony v2.13.0
model *BIOMD0000000010()

  // Compartments and Species:
  compartment uVol;
  species MKKK in uVol, MKKK_P in uVol, MKK in uVol, MKK_P in uVol, MKK_PP in uVol;
  species MAPK in uVol, MAPK_P in uVol, MAPK_PP in uVol;

  // Reactions:
  J0: MKKK => MKKK_P; uVol*J0_V1*MKKK/((1 + (MAPK_PP/J0_Ki)^J0_n)*(J0_K1 + MKKK));
  J1: MKKK_P => MKKK; uVol*J1_V2*MKKK_P/(J1_KK2 + MKKK_P);
  J2: MKK => MKK_P; uVol*J2_k3*MKKK_P*MKK/(J2_KK3 + MKK);
  J3: MKK_P => MKK_PP; uVol*J3_k4*MKKK_P*MKK_P/(J3_KK4 + MKK_P);
  J4: MKK_PP => MKK_P; uVol*J4_V5*MKK_PP/(J4_KK5 + MKK_PP);
  J5: MKK_P => MKK; uVol*J5_V6*MKK_P/(J5_KK6 + MKK_P);
  J6: MAPK => MAPK_P; uVol*J6_k7*MKK_PP*MAPK/(J6_KK7 + MAPK);
  J7: MAPK_P => MAPK_PP; uVol*J7_k8*MKK_PP*MAPK_P/(J7_KK8 + MAPK_P);
  J8: MAPK_PP => MAPK_P; uVol*J8_V9*MAPK_PP/(J8_KK9 + MAPK_PP);
  J9: MAPK_P => MAPK; uVol*J9_V10*MAPK_P/(J9_KK10 + MAPK_P);

  // Species initializations:
  MKKK = 90;
  MKKK_P = 10;
  MKK = 280;
  MKK_P = 10;
  MKK_PP = 10;
  MAPK = 280;
  MAPK_P = 10;
  MAPK_PP = 10;

  // Compartment initializations:
  uVol = 1;

  // Variable initializations:
  J0_V1 = 2.5;
  J0_Ki = 9;
  J0_n = 1;
  J0_K1 = 10;
  J1_V2 = 0.25;
  J1_KK2 = 8;
  J2_k3 = 0.025;
  J2_KK3 = 15;
  J3_k4 = 0.025;
  J3_KK4 = 15;
  J4_V5 = 0.75;
  J4_KK5 = 15;
  J5_V6 = 0.75;
  J5_KK6 = 15;
  J6_k7 = 0.025;
  J6_KK7 = 15;
  J7_k8 = 0.025;
  J7_KK8 = 15;
  J8_V9 = 0.5;
  J8_KK9 = 15;
  J9_V10 = 0.5;
  J9_KK10 = 15;

  // Other declarations:
  const uVol;

  // Unit definitions:
  unit substance = 1e-9 mole;

  // Display Names:
  substance is "nanomole";
  MKKK is "Mos";
  MKKK_P is "Mos-P";
  MKK is "Mek1";
  MKK_P is "Mek1-P";
  MKK_PP is "Mek1-PP";
  MAPK is "Erk2";
  MAPK_P is "Erk2-P";
  MAPK_PP is "Erk2-PP";
  J0 is "MAPKKK activation";
  J1 is "MAPKKK inactivation";
  J2 is "phosphorylation of MAPKK";
  J3 is "phosphorylation of MAPKK-P";
  J4 is "dephosphorylation of MAPKK-PP";
  J5 is "dephosphorylation of MAPKK-P";
  J6 is "phosphorylation of MAPK";
  J7 is "phosphorylation of MAPK-P";
  J8 is "dephosphorylation of MAPK-PP";
  J9 is "dephosphorylation of MAPK-P";

  // CV terms:
  MKKK hypernym "http://identifiers.org/uniprot/P09560"
  MKKK_P hypernym "http://identifiers.org/uniprot/P09560"
  MKK hypernym "http://identifiers.org/uniprot/Q05116"
  MKK_P hypernym "http://identifiers.org/uniprot/Q05116"
  MKK_PP hypernym "http://identifiers.org/uniprot/Q05116"
  MAPK hypernym "http://identifiers.org/uniprot/P26696"
  MAPK_P hypernym "http://identifiers.org/uniprot/P26696"
  MAPK_PP hypernym "http://identifiers.org/uniprot/P26696"
  J0 homolog "http://identifiers.org/reactome/REACT_525"
  J0 hypernym "http://identifiers.org/ec-code/2.7.11.1",
              "http://identifiers.org/go/GO:0000185",
              "http://identifiers.org/go/GO:0008349"
  J1 hypernym "http://identifiers.org/ec-code/3.1.3.16",
              "http://identifiers.org/go/GO:0051390",
              "http://identifiers.org/go/GO:0006470"
  J2 homolog "http://identifiers.org/reactome/REACT_614"
  J2 hypernym "http://identifiers.org/ec-code/2.7.11.25",
              "http://identifiers.org/go/GO:0004709",
              "http://identifiers.org/go/GO:0006468"
  J3 homolog "http://identifiers.org/reactome/REACT_614"
  J3 hypernym "http://identifiers.org/ec-code/2.7.11.25",
              "http://identifiers.org/go/GO:0000186",
              "http://identifiers.org/go/GO:0006468",
              "http://identifiers.org/go/GO:0004709"
  J4 hypernym "http://identifiers.org/ec-code/3.1.3.16",
              "http://identifiers.org/go/GO:0006470",
              "http://identifiers.org/go/GO:0051389"
  J5 hypernym "http://identifiers.org/ec-code/3.1.3.16",
              "http://identifiers.org/go/GO:0006470"
  J6 version "http://identifiers.org/reactome/REACT_136",
             "http://identifiers.org/reactome/REACT_2247"
  J6 hypernym "http://identifiers.org/ec-code/2.7.12.2",
              "http://identifiers.org/go/GO:0004708",
              "http://identifiers.org/go/GO:0006468"
  J7 version "http://identifiers.org/reactome/REACT_136",
             "http://identifiers.org/reactome/REACT_2247"
  J7 hypernym "http://identifiers.org/ec-code/2.7.12.2",
              "http://identifiers.org/go/GO:0006468",
              "http://identifiers.org/go/GO:0004708",
              "http://identifiers.org/go/GO:0000187"
  J8 hypernym "http://identifiers.org/ec-code/3.1.3.16",
              "http://identifiers.org/go/GO:0000188",
              "http://identifiers.org/go/GO:0006470"
  J9 hypernym "http://identifiers.org/ec-code/3.1.3.16",
              "http://identifiers.org/go/GO:0006470"
end

BIOMD0000000010 is "Kholodenko2000 - Ultrasensitivity and negative feedback bring oscillations in MAPK cascade"

BIOMD0000000010 model_entity_is "http://identifiers.org/biomodels.db/MODEL6615119181"
BIOMD0000000010 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000010"
BIOMD0000000010 description "http://identifiers.org/pubmed/10712587"
BIOMD0000000010 hypernym "http://identifiers.org/go/GO:0000165"
BIOMD0000000010 homolog "http://identifiers.org/reactome/REACT_634"
BIOMD0000000010 taxon "http://identifiers.org/taxonomy/8355"
