Passengers who take prescription or over-the-counter medications should review this guidance before travel and discuss their specific medications with their physician when obtaining medical clearance. The low-gravity transit environment and the elevated g-loads during departure and arrival burns can affect how certain medications behave in the body.

Medications that are contraindicated or require physician review for spaceflight include: anticoagulants (warfarin/Coumadin, rivaroxaban/Xarelto, apixaban/Eliquis, dabigatran/Pradaxa, and related drugs) — the fluid shifts in low gravity affect distribution and the g-load burns add cardiovascular stress; discuss dosing with the prescribing physician and the Pelorus Voyages flight surgeon in advance. Diuretics (furosemide/Lasix, hydrochlorothiazide/HCTZ, spironolactone/Aldactone) — the fluid redistribution in low gravity can interact unpredictably with diuretic action; increased monitoring is required. Vestibular suppressants (meclizine/Antivert, dimenhydrinate/Dramamine, promethazine/Phenergan, scopolamine patch) — these are commonly used for motion sickness adaptation and are stocked in the medical bay; passengers who anticipate needing them may obtain them from the medical bay rather than bringing their own. Benzodiazepines (diazepam/Valium, lorazepam/Ativan, alprazolam/Xanax) — acceptable for occasional use but not recommended as the sole coping strategy for a multi-week voyage; discuss with prescribing physician.

Medications that are specifically prohibited aboard Pelorus Voyages vessels due to fire or contamination risk include: liquid oxygen concentrators (solid-state supplemental oxygen is available from the medical bay as an alternative), aerosol inhalers using flammable propellants (dry powder inhalers and soft mist inhalers are acceptable alternatives), and controlled substance injectable medications unless declared in advance and transported in certified sealed containers.

All prescription medications must be carried in their original pharmacy-labelled containers. If a medication name on the label differs from the name used in the passenger's medical documents — due to a brand-versus-generic difference, an international naming convention, or a reformulation — the passenger should carry documentation from the prescribing physician clarifying the equivalence. Customs and security authorities at interplanetary waypoints have increasingly diverse pharmacopeias and naming conventions; the original container and a physician letter are the most reliable documentation.

A sufficient supply of all essential medications for the full voyage plus a 14-day buffer should be packed in the passenger's carry-on, not checked baggage. The 14-day buffer accounts for the possibility of a scrub, a diversion, or an extension of any leg. Medications in checked baggage that are separated from the passenger in a baggage incident are not readily replaceable mid-voyage.
