ComplexID	ComplexName	Organism	Synonyms	Cell line	subunits(UniProt IDs)	subunits(Entrez IDs)	Protein complex purification method	GO ID	GO description	FunCat ID	FunCat description	PubMed ID	Complex comment	Disease comment	Subunits comment	SWISSPROT organism	subunits(Protein name)	subunits(Gene name)	subunits(Gene name syn)
1	BCL6-HDAC4 complex	Human	None	U2OS osteosarcoma-derived UTA-L cells	P41182;P56524	604;9759	MI:0007-anti tag coimmunoprecipitation	GO:0006265;GO:0045892;GO:0051276;GO:0030183;GO:0005634;GO:0016575	DNA topological change;negative regulation of DNA-templated transcription;chromosome organization;B cell differentiation;nucleus;histone deacetylation	10.01.09.05;11.02.03.04.03;42.10.03;43.03.07.02.01.01;70.10	DNA conformation modification (e.g. chromatin);transcription repression;organization of chromosome structure;B-cell;nucleus	11929873	Transcriptional repression by BCL6 is thought to be achieved in part by recruiting a repressor complex containing histone deacetylases.	None	None	Homo sapiens (Human);Homo sapiens (Human)	B-cell lymphoma 6 protein;Histone deacetylase 4	BCL6;HDAC4	BCL5 LAZ3 ZBTB27 ZNF51;KIAA0288
2	BCL6-HDAC5 complex	Human	None	U2OS osteosarcoma-derived UTA-L cells	P41182;Q9UQL6	604;10014	MI:0007-anti tag coimmunoprecipitation	GO:0006265;GO:0045892;GO:0051276;GO:0030183;GO:0005634;GO:0016575	DNA topological change;negative regulation of DNA-templated transcription;chromosome organization;B cell differentiation;nucleus;histone deacetylation	10.01.09.05;11.02.03.04.03;42.10.03;43.03.07.02.01.01;70.10	DNA conformation modification (e.g. chromatin);transcription repression;organization of chromosome structure;B-cell;nucleus	11929873	Transcriptional repression by BCL6 is thought to be achieved in part by recruiting a repressor complex containing histone deacetylases.	None	None	Homo sapiens (Human);Homo sapiens (Human)	B-cell lymphoma 6 protein;Histone deacetylase 5	BCL6;HDAC5	BCL5 LAZ3 ZBTB27 ZNF51;KIAA0600
3	BCL6-HDAC7 complex	Human	None	U2OS osteosarcoma-derived UTA-L cells	P41182;Q8WUI4	604;51564	MI:0007-anti tag coimmunoprecipitation	GO:0006265;GO:0045892;GO:0051276;GO:0030183;GO:0005634;GO:0016575	DNA topological change;negative regulation of DNA-templated transcription;chromosome organization;B cell differentiation;nucleus;histone deacetylation	10.01.09.05;11.02.03.04.03;42.10.03;43.03.07.02.01.01;70.10	DNA conformation modification (e.g. chromatin);transcription repression;organization of chromosome structure;B-cell;nucleus	11929873	Transcriptional repression by BCL6 is thought to be achieved in part by recruiting a repressor complex containing histone deacetylases.	None	None	Homo sapiens (Human);Homo sapiens (Human)	B-cell lymphoma 6 protein;Histone deacetylase 7	BCL6;HDAC7	BCL5 LAZ3 ZBTB27 ZNF51;HDAC7A
4	Multisubunit ACTR coactivator complex	Human	None	different human tissues and cancer cell lines	Q09472;Q92793;Q92831;Q9Y6Q9	2033;1387;8850;8202	MI:0004-affinity chromatography technology;MI:0018-two hybrid;MI:0096-pull down	GO:0030374;GO:0004402	nuclear receptor coactivator activity;histone acetyltransferase activity	None	None	9267036	Cofactor ACTR binds directly nuclear receptors and stimulates their transcriptional activities in a hormone-dependent fashion.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone acetyltransferase p300;CREB-binding protein;Histone acetyltransferase KAT2B;Nuclear receptor coactivator 3	EP300;CREBBP;KAT2B;NCOA3	P300;CBP;PCAF;AIB1 BHLHE42 RAC3 TRAM1
10	Condensin I complex	Human	13S condensin complex	HeLa cells	O95347;Q15003;Q15021;Q9BPX3;Q9NTJ3	10592;23397;9918;64151;10051	MI:0004-affinity chromatography technology;MI:0019-coimmunoprecipitation	GO:0000279;GO:0030261;GO:0007059;GO:0051276;GO:0005694;GO:0000278	M phase;chromosome condensation;chromosome segregation;chromosome organization;chromosome;mitotic cell cycle	10.03.01.01.11;10.03.04.03;10.03.04.05;42.10.03;70.10.03;10.03.01.01	M phase;chromosome condensation;chromosome segregation/division;organization of chromosome structure;chromosome;mitotic cell cycle	11136719	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Structural maintenance of chromosomes protein 2;Condensin complex subunit 2;Condensin complex subunit 1;Condensin complex subunit 3;Structural maintenance of chromosomes protein 4	SMC2;NCAPH;NCAPD2;NCAPG;SMC4	CAPE SMC2L1;BRRN BRRN1 CAPH KIAA0074;CAPD2 CNAP1 KIAA0159;CAPG NYMEL3;CAPC SMC4L1
11	BLOC-3 (biogenesis of lysosome-related organelles complex 3)	Human	None	None	Q92902;Q9NQG7	3257;89781	MI:0019-coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0007032;GO:0007040;GO:0007033	endosome organization;lysosome organization;vacuole organization	42.22;42.25	endosome;vacuole or lysosome	12847290	The results suggest that HPS1 and HPS4 are components of a protein complex that regulates the intracellular localization of lysosomes and late endosomes and may function in a BLOC-1-dependent pathway for melanosome biogenesis.	HPS1-7 are involved in Hermansky-Pudlak syndrome (HPS), which  comprises at least seven different autosomal recessive disorders (referred to as HPS-1 through -7) that share the clinical manifestations of oculocutaneous albinism combined with platelet storage pool deficiency and do not present with the severe immunodeficiency and giant intracellular granules characteristic of Chediak-Higashi syndrome (PMID:15030569).	None	Homo sapiens (Human);Homo sapiens (Human)	BLOC-3 complex member HPS1;BLOC-3 complex member HPS4	HPS1;HPS4	HPS;KIAA1667
12	BLOC-2 (biogenesis of lysosome-related organelles complex 2)	Human	None	None	Q86YV9;Q969F9;Q9UPZ3	79803;84343;11234	MI:0019-coimmunoprecipitation;MI:0029-cosedimentation through density gradient;MI:0071-molecular sieving	GO:0007032;GO:0007040;GO:0007033	endosome organization;lysosome organization;vacuole organization	42.22;42.25	endosome;vacuole or lysosome	15030569	The results suggest that BLOC-2 is not critical for basal levels of secretion of lysosomal enzymes by fibroblasts.	HPS1-7 are involved in Hermansky-Pudlak syndrome (HPS), which  comprises at least seven different autosomal recessive disorders (referred to as HPS-1 through -7) that share the clinical manifestations of oculocutaneous albinism combined with platelet storage pool deficiency and do not present with the severe immunodeficiency and giant intracellular granules characteristic of Chediak-Higashi syndrome.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	BLOC-2 complex member HPS6;BLOC-2 complex member HPS3;BLOC-2 complex member HPS5	HPS6;HPS3;HPS5	None;None;AIBP63 KIAA1017
13	CDS1 -MUS81 complex	Human	None	HeLa cells	Q92903;Q96NY9	1040;80198	MI:0004-affinity chromatography technology	GO:0006281;GO:0006310	DNA repair;DNA recombination	10.01.05.01;10.01.05.03	DNA repair;DNA recombination	11741546	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Phosphatidate cytidylyltransferase 1;Crossover junction endonuclease MUS81	CDS1;MUS81	CDS;None
15	NCOR complex	Human	NCOR1 complex	HeLa cells	O15379;O60907;O75376;Q13227;Q92828;Q9BZK7	8841;6907;9611;2874;7464;79718	MI:0004-affinity chromatography technology;MI:0019-coimmunoprecipitation;MI:0069-mass spectrometry studies of complexes;MI:0096-pull down	GO:0006265;GO:0045892;GO:0006473;GO:0006476;GO:0051276;GO:0005634	DNA topological change;negative regulation of DNA-templated transcription;protein acetylation;protein deacetylation;chromosome organization;nucleus	10.01.09.05;11.02.03.04.03;14.07.04;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription repression;modification by acetylation, deacetylation;organization of chromosome structure;nucleus	12628926	Corepressors N-CoR and SMRT participate in diverse repression pathways and exist in large protein complexes including HDAC3, TBL1 and TBLR1. The purified N-CoR complex contains 10-12 associated proteins, including previously identified components and a novel actin-binding protein IR10. It is shown that TBL1/TBLR1 associates with N-CoR through two independent interactions: the N-terminal region and the C-terminal WD-40 repeats interact with the N-CoR RD1 and RD4 region, respectively. In vitro, TBL1/TBLR1 bind histones H2B and H4, and, importantly, repression by TBL1/TBLR1 correlates with their interaction with histones. By using specific small interference RNAs (siRNAs), the authors demonstrate that HDAC3 is essential, whereas TBL1 and TBLR1 are functionally redundant but essential for repression by unliganded thyroid hormone receptor.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone deacetylase 3;F-box-like/WD repeat-containing protein TBL1X;Nuclear receptor corepressor 1;G protein pathway suppressor 2;Coronin-2A;F-box-like/WD repeat-containing protein TBL1XR1	HDAC3;TBL1X;NCOR1;GPS2;CORO2A;TBL1XR1	None;TBL1;KIAA1047;None;IR10 WDR2;IRA1 TBLR1
23	BLOC-1 (biogenesis of lysosome-related organelles complex 1)	Human	None	None	O95295;P78537;Q6QNY0;Q6QNY1;Q8TDH9;Q96EV8;Q9NUP1;Q9UL45	23557;2647;388552;282991;63915;84062;55330;26258	MI:0019-coimmunoprecipitation	None	None	None	None	15102850	The authors identified Snapin, BLOS1, BLOS2, and BLOS3 as subunits of BLOC-1 and found that the HPS mouse model strain, reduced pigmentation, carries a nonsense mutation in BLOS3. The genes encoding these proteins may underlie the pathogenesis of novel forms of HPS in patients having no detectable mutation in any of the genes that cause HPS types 1-7.	PLDN, MUTED, CNO and DTNBP1 are involved in Hermansky-Pudlak syndrome (HPS), a genetic disorder characterized by hypopigmentation and platelet storage pool deficiency.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	SNARE-associated protein Snapin;Biogenesis of lysosome-related organelles complex 1 subunit 1;Biogenesis of lysosome-related organelles complex 1 subunit 3;Biogenesis of lysosome-related organelles complex 1 subunit 2;Biogenesis of lysosome-related organelles complex 1 subunit 5;Dysbindin;Biogenesis of lysosome-related organelles complex 1 subunit 4;Biogenesis of lysosome-related organelles complex 1 subunit 6	SNAPIN;BLOC1S1;BLOC1S3;BLOC1S2;BLOC1S5;DTNBP1;BLOC1S4;BLOC1S6	BLOC1S7 SNAP25BP SNAPAP;BLOS1 GCN5L1 RT14;BLOS3;BLOS2 CEAP;MUTED;BLOC1S8;CNO;PA, PLDN
27	Arp2/3 protein complex	Human	ARP2/3 protein complex	Neutrophils	O15143;O15144;O15145;O15511;P59998;P61158;P61160	10095;10109;10094;10092;10093;10096;10097	MI:0027-cosedimentation;MI:0071-molecular sieving	GO:0005885;GO:0030833	Arp2/3 protein complex;regulation of actin filament polymerization	None	None	9359840	None	Transcript levels of ARP2/3 complex subunits, and of nucleation promotion factors that regulate the ARP2/3 complex, were significantly lower in DLPFC layer 3 and 5 pyramidal cells in schizophrenia. In contrast, these transcripts were unaltered, or only modestly changed, in parvalbumin interneurons and DLPFC gray matter (PMID:27523502)	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Actin-related protein 2/3 complex subunit 1B;Actin-related protein 2/3 complex subunit 2;Actin-related protein 2/3 complex subunit 3;Actin-related protein 2/3 complex subunit 5;Actin-related protein 2/3 complex subunit 4;Actin-related protein 3;Actin-related protein 2	ARPC1B;ARPC2;ARPC3;ARPC5;ARPC4;ACTR3;ACTR2	ARC41;ARC34;ARC21;ARC16;ARC20;ARP3;ARP2
29	PA28gamma complex	Human	None	None	P61289	10197	MI:0071-molecular sieving;MI:0226-ion exchange chromatography	GO:0043161;GO:0005515;GO:0016504	proteasome-mediated ubiquitin-dependent protein catabolic process;protein binding;peptidase activator activity	14.13.01.01;16.01;18.02.01.01.03	proteasomal degradation (ubiquitin/proteasomal pathway);protein binding;protease activator	9325261	None	None	According to gel filtration chromatography experiments, the protein complex probably consists of seven identical subunits.	Homo sapiens (Human)	Proteasome activator complex subunit 3	PSME3	None
30	PA28 complex	Human	11S REG	None	Q06323;Q9UL46	5720;5721	MI:0071-molecular sieving;MI:0226-ion exchange chromatography	GO:0043161;GO:0006511;GO:0051098;GO:0005515;GO:0016504;GO:0005737	proteasome-mediated ubiquitin-dependent protein catabolic process;ubiquitin-dependent protein catabolic process;regulation of binding;protein binding;peptidase activator activity;cytoplasm	14.13.01.01;18.01.07;16.01;18.02.01.01.03;70.03	proteasomal degradation (ubiquitin/proteasomal pathway);regulation by binding / dissociation;protein binding;protease activator;cytoplasm	9325261	PA28 is a regulatory complex of the 20S proteasome. It acts as proteasome activator and stimulates cleavage after basic, acidic, and most hydrophobic residues in many peptides.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Proteasome activator complex subunit 1;Proteasome activator complex subunit 2	PSME1;PSME2	IFI5111;None
32	PA700 complex	Human	19S complex	None	O00231;O00232;O00233;O00487;O43242;O75832;P17980;P35998;P43686;P48556;P51665;P55036;P62191;P62195;P62333;Q13200;Q15008;Q16401;Q99460;Q9UNM6	5717;5718;5715;10213;5709;5716;5702;5701;5704;5714;5713;5710;5700;5705;5706;5708;9861;5711;5707;5719	MI:0071-molecular sieving;MI:0226-ion exchange chromatography	GO:0043161;GO:0005515;GO:0016504	proteasome-mediated ubiquitin-dependent protein catabolic process;protein binding;peptidase activator activity	14.13.01.01;16.01;18.02.01.01.03	proteasomal degradation (ubiquitin/proteasomal pathway);protein binding;protease activator	9148964	The proteasome is an essential component of the ATP-dependent proteolytic pathway in eukaryotic cells and is responsible for the degradation of most cellular proteins (for reviews see PMID:8811196 and PMID:10872471). It contains a barrel-shaped proteolytic core complex (the 20S proteasome), and is capped at one or both ends by regulatory complexes like the 19S complex (PMID:11812135), modulator (PMID:8621709), PA28 (PMID:9325261) and PA28gamma (PMID:9325261). Interferon-gamma (IFN-gamma) alters the peptide-degrading specificity of proteasomes and produces an immunoproteasome responsible for accelerated processing of nonself endogenous antigens by inducing the replacement of subunits Psmb5, Psmb6 and Psmb7 by Psmb8, Psmb9 and Psmb10, respectively.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	26S proteasome non-ATPase regulatory subunit 11;26S proteasome non-ATPase regulatory subunit 12;26S proteasome non-ATPase regulatory subunit 9;26S proteasome non-ATPase regulatory subunit 14;26S proteasome non-ATPase regulatory subunit 3;26S proteasome non-ATPase regulatory subunit 10;26S proteasome regulatory subunit 6A;26S proteasome regulatory subunit 7;26S proteasome regulatory subunit 6B;26S proteasome non-ATPase regulatory subunit 8;26S proteasome non-ATPase regulatory subunit 7;26S proteasome non-ATPase regulatory subunit 4;26S proteasome regulatory subunit 4;26S proteasome regulatory subunit 8;26S proteasome regulatory subunit 10B;26S proteasome non-ATPase regulatory subunit 2;26S proteasome non-ATPase regulatory subunit 6;26S proteasome non-ATPase regulatory subunit 5;26S proteasome non-ATPase regulatory subunit 1;26S proteasome non-ATPase regulatory subunit 13	PSMD11;PSMD12;PSMD9;PSMD14;PSMD3;PSMD10;PSMC3;PSMC2;PSMC4;PSMD8;PSMD7;PSMD4;PSMC1;PSMC5;PSMC6;PSMD2;PSMD6;PSMD5;PSMD1;PSMD13	None;None;None;POH1;None;None;TBP1;MSS1;MIP224 TBP7;None;MOV34L;MCB1;None;SUG1;SUG2;TRAP2;KIAA0107 PFAAP4;KIAA0072;None;None
36	AP1 adaptor complex	Human	None	293 cells	O43747;O75843;P56377;P61966;Q10567;Q96PC3;Q9BXS5;Q9Y6Q5	164;8906;8905;1174;162;130340;8907;10053	MI:0018-two hybrid	GO:0006886;GO:0006605;GO:0015031;GO:0016192;GO:0006900;GO:0016050;GO:0006897;GO:0030133	intracellular protein transport;protein targeting;protein transport;vesicle-mediated transport;vesicle budding from membrane;vesicle organization;endocytosis;transport vesicle	14.04;20.01.10;20.09.07;20.09.07.25;20.09.18.09.01;70.09	protein targeting, sorting and translocation;protein transport;vesicular transport (Golgi network, etc.);vesicle formation;endocytosis;intracellular transport vesicles	9733768	This adaptor-related complex participates in a transport step different from that of AP-1. It may function at some trafficking step in the complex pathways between the TGN and the cell surface.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	AP-1 complex subunit gamma-1;AP-1 complex subunit gamma-like 2;AP-1 complex subunit sigma-2;AP-1 complex subunit sigma-1A;AP-1 complex subunit beta-1;AP-1 complex subunit sigma-3;AP-1 complex subunit mu-1;AP-1 complex subunit mu-2	AP1G1;AP1G2;AP1S2;AP1S1;AP1B1;AP1S3;AP1M1;AP1M2	ADTG CLAPG1;None;None;AP19 CLAPS1;ADTB1 BAM22 CLAPB2;None;CLTNM;None
45	Gamma-secretase complex (APH1A, PSEN1, PSENEN, NCSTN)	Human	None	None	P49768;Q92542;Q96BI3;Q9NZ42	5663;23385;51107;55851	MI:0007-anti tag coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0016485;GO:0051090;GO:0007219;GO:0005886;GO:0005794	protein processing;regulation of DNA-binding transcription factor activity;Notch signaling pathway;plasma membrane;Golgi apparatus	14.07.11;18.02.09;30.05.02.14;70.02;70.08	protein processing (proteolytic);regulator of transcription factor;Notch-receptor signalling pathway;eukaryotic plasma membrane / membrane attached;Golgi	15274632	Proteolytic cleavage within the hydrophobic transmembrane domains of Notch and APP are intimately associated with a multimeric gamma-secretase complex that contains the presenilin-1 or presenilin-2 and the membrane glycoprotein nicastrin. Three variants of APH1 (APH1A short, APH1A long and APH1B) as well as two presenillin variants (PSEN1 and PSEN2) allow the formation of six different gamma-secretase complexes.	Gamma-secretase is causally implicated in Alzheimer's disease.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Presenilin-1;Nicastrin;Gamma-secretase subunit APH-1A;Gamma-secretase subunit PEN-2	PSEN1;NCSTN;APH1A;PSENEN	AD3 PS1 PSNL1;KIAA0253;PSF;PEN2
49	DNMT3B complex	Human	None	HeLa cells	O60264;O95239;O95347;Q13547;Q96ST3;Q9NTJ3;Q9UBC3	8467;24137;10592;3065;25942;10051;1789	MI:0019-coimmunoprecipitation	GO:0006306;GO:0006265;GO:0000279;GO:0007059;GO:0051276;GO:0005694;GO:0000278	DNA methylation;DNA topological change;M phase;chromosome segregation;chromosome organization;chromosome;mitotic cell cycle	10.01.09.01;10.01.09.05;10.03.01.01.11;10.03.04.05;42.10.03;70.10.03;10.03.01.01	DNA methylation;DNA conformation modification (e.g. chromatin);M phase;chromosome segregation/division;organization of chromosome structure;chromosome;mitotic cell cycle	15148359	None	The DNA methyltransferase DNMT3B is frequently overexpressed in tumor cells and is mutated in immunodeficiency, centromere instability and facial anomalies (ICF) syndrome.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5;Chromosome-associated kinesin KIF4A;Structural maintenance of chromosomes protein 2;Histone deacetylase 1;Paired amphipathic helix protein Sin3a;Structural maintenance of chromosomes protein 4;DNA	SMARCA5;KIF4A;SMC2;HDAC1;SIN3A;SMC4;DNMT3B	SNF2H, WCRF135;KIF4;CAPE SMC2L1;RPD3L1;None;CAPC SMC4L1;None
50	RAB5A-RABEP1-RABGEF complex	Human	RAB5-RABAPTIN5\u2013RABEX5 complex	HeLa cells	P20339;Q15276;Q9UJ41	5868;9135;27342	MI:0018-two hybrid;MI:0019-coimmunoprecipitation;MI:0091-chromatography technology;MI:0096-pull down	GO:0006897;GO:0061025;GO:0034058	endocytosis;membrane fusion;endosomal vesicle fusion	20.09.18.09.01	endocytosis	9323142	The Rab5-binding protein, Rabex-5, forms a tight physical complex with Rabaptin-5, and this complex is required for both the homotypic and heterotypic endosome fusion.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Ras-related protein Rab-5A;Rab GTPase-binding effector protein 1;Rab5 GDP/GTP exchange factor	RAB5A;RABEP1;RABGEF1	RAB5;RAB5EP RABPT5 RABPT5A;RABEX5
55	HDAC4-ERK1 complex	Human	None	None	P27361;P56524	5595;9759	MI:0007-anti tag coimmunoprecipitation	GO:0006265;GO:2001141;GO:0006355;GO:0000165;GO:0051276;GO:0005634	DNA topological change;regulation of RNA biosynthetic process;regulation of DNA-templated transcription;MAPK cascade;chromosome organization;nucleus	10.01.09.05;11.02.03.04;30.01.05.01.03;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcriptional control;MAPKKK cascade;organization of chromosome structure;nucleus	11114188	ERK1 activity links the Ras-MAPK signal transduction pathway to a mechanism for chromatin remodeling (i.e., histone deacetylation).	None	None	Homo sapiens (Human);Homo sapiens (Human)	Mitogen-activated protein kinase 3;Histone deacetylase 4	MAPK3;HDAC4	ERK1 PRKM3;KIAA0288
57	HDAC4-ERK2 complex	Human	None	None	P28482;P56524	5594;9759	MI:0007-anti tag coimmunoprecipitation	GO:0006265;GO:2001141;GO:0006355;GO:0000165;GO:0051276;GO:0005634	DNA topological change;regulation of RNA biosynthetic process;regulation of DNA-templated transcription;MAPK cascade;chromosome organization;nucleus	10.01.09.05;11.02.03.04;30.01.05.01.03;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcriptional control;MAPKKK cascade;organization of chromosome structure;nucleus	11114188	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Mitogen-activated protein kinase 1;Histone deacetylase 4	MAPK1;HDAC4	ERK2 PRKM1 PRKM2;KIAA0288
58	SMRT complex	Human	NCOR2 complex	HeLa nuclear extract	O15379;O60907;Q13227;Q9BZK7;Q9Y618	8841;6907;2874;79718;9612	MI:0004-affinity chromatography technology;MI:0019-coimmunoprecipitation;MI:0069-mass spectrometry studies of complexes;MI:0096-pull down	GO:0006265;GO:0045892;GO:0006473;GO:0006476;GO:0051276;GO:0005634	DNA topological change;negative regulation of DNA-templated transcription;protein acetylation;protein deacetylation;chromosome organization;nucleus	10.01.09.05;11.02.03.04.03;14.07.04;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription repression;modification by acetylation, deacetylation;organization of chromosome structure;nucleus	12628926	Corepressors N-CoR and SMRT participate in diverse repression pathways and exist in large protein complexes including HDAC3, TBL1 and TBLR1. IR10, a subunit of the N-CoR complex, does not associate with SMRT (NCOR2).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone deacetylase 3;F-box-like/WD repeat-containing protein TBL1X;G protein pathway suppressor 2;F-box-like/WD repeat-containing protein TBL1XR1;Nuclear receptor corepressor 2	HDAC3;TBL1X;GPS2;TBL1XR1;NCOR2	None;TBL1;None;IRA1 TBLR1;CTG26
59	AP3 adaptor complex	Human	None	in vitro	O00203;O14617;P53677;P59780;Q13367;Q92572;Q9Y2T2	8546;8943;10947;10239;8120;1176;26985	MI:0019-coimmunoprecipitation;MI:0051-fluorescence technology	GO:0006886;GO:0006605;GO:0015031;GO:0006892;GO:0006897;GO:0005773;GO:0005764;GO:0016192	intracellular protein transport;protein targeting;protein transport;post-Golgi vesicle-mediated transport;endocytosis;vacuole;lysosome;vesicle-mediated transport	14.04;20.01.10;20.09.07.06;20.09.18.09.01;70.25;20.09.07	protein targeting, sorting and translocation;protein transport;post Golgi transport;endocytosis;vacuole or lysosome;vesicular transport (Golgi network, etc.)	9151686	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	AP-3 complex subunit beta-1;AP-3 complex subunit delta-1;AP-3 complex subunit mu-2;AP-3 complex subunit sigma-2;AP-3 complex subunit beta-2;AP-3 complex subunit sigma-1;AP-3 complex subunit mu-1	AP3B1;AP3D1;AP3M2;AP3S2;AP3B2;AP3S1;AP3M1	ADTB3A;None;None;None;None;CLAPS3;None
61	Mi2/NuRD complex	Human	Mi2-beta-histone deacetylase complex	HeLa cells	O94776;O95983;Q09028;Q13547;Q14839;Q16576;Q92769	9219;53615;5928;3065;1108;5931;3066	MI:0004-affinity chromatography technology	GO:0006265;GO:0051276;GO:0005634;GO:0006357	DNA topological change;chromosome organization;nucleus;regulation of transcription by RNA polymerase II	10.01.09.05;42.10.03;70.10	DNA conformation modification (e.g. chromatin);organization of chromosome structure;nucleus	9790534	None	Dermatomyositis, cancer (PMID:9790534)	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Metastasis-associated protein MTA2;Methyl-CpG-binding domain protein 3;Histone-binding protein RBBP4;Histone deacetylase 1;Chromodomain-helicase-DNA-binding protein 4;Histone-binding protein RBBP7;Histone deacetylase 2	MTA2;MBD3;RBBP4;HDAC1;CHD4;RBBP7;HDAC2	MTA1L1 PID;None;RBAP48;RPD3L1;None;RBAP46;None
62	MeCP1 complex	Human	Mi2/NuRD-MBD2 complex	HeLa cells	O94776;O95983;Q09028;Q13547;Q14839;Q16576;Q92769;Q9UBB5	9219;53615;5928;3065;1108;5931;3066;8932	MI:0096-pull down	GO:0006265;GO:0045892;GO:0003677;GO:0051276;GO:0005634;GO:0016575	DNA topological change;negative regulation of DNA-templated transcription;DNA binding;chromosome organization;nucleus;histone deacetylation	10.01.09.05;11.02.03.04.03;16.03.01;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription repression;DNA binding;organization of chromosome structure;nucleus	10444591	MeCP1 protein complex represses transcription through preferential binding, remodeling, and deacetylation of methylated nucleosomes.	CHD4 is involved in dermatomyositis (PMID:9790534).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Metastasis-associated protein MTA2;Methyl-CpG-binding domain protein 3;Histone-binding protein RBBP4;Histone deacetylase 1;Chromodomain-helicase-DNA-binding protein 4;Histone-binding protein RBBP7;Histone deacetylase 2;Methyl-CpG-binding domain protein 2	MTA2;MBD3;RBBP4;HDAC1;CHD4;RBBP7;HDAC2;MBD2	MTA1L1 PID;None;RBAP48;RPD3L1;None;RBAP46;None;None
66	TRAP complex	Human	thyroid hormone receptor-associated protein complex	HeLa cells	O60244;O75448;P10827;Q15648;Q93074;Q9NVC6;Q9Y2W1;Q9Y2X0	9282;9862;7067;5469;9968;9440;9967;10025	MI:0004-affinity chromatography technology;MI:0019-coimmunoprecipitation;MI:0276-blue native page	GO:0045893;GO:0030545;GO:0009755;GO:0023052;GO:0005634	positive regulation of DNA-templated transcription;signaling receptor regulator activity;hormone-mediated signaling pathway;signaling;nucleus	11.02.03.04.01;18.02.07;30.01.09.08;30.01;70.10	transcription activation;regulator of receptor activity;hormone mediated signal transduction;cellular signalling;nucleus	8710870	The human thyroid hormone receptor-associated protein (TRAP) complex is a coactivator for nuclear receptors. Several identical subunits appear in protein complexes like DRIP/ARC, CRSP, NAT, PC2, SMCC and Mediator, indicating that unique classes of transcription activators may share common sets or subsets of cofactors.	None	TRAP97 and 93 could not be found in the Uniprot database.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mediator of RNA polymerase II transcription subunit 14;Mediator of RNA polymerase II transcription subunit 24;Thyroid hormone receptor alpha;Mediator of RNA polymerase II transcription subunit 1;Mediator of RNA polymerase II transcription subunit 12;Mediator of RNA polymerase II transcription subunit 17;Thyroid hormone receptor-associated protein 3;Mediator of RNA polymerase II transcription subunit 16	MED14;MED24;THRA;MED1;MED12;MED17;THRAP3;MED16	ARC150 CRSP2 CXorf4 DRIP150 EXLM1 RGR1 TRAP170;ARC100 CRSP4 DRIP100 KIAA0130 THRAP4 TRAP100;EAR7 ERBA1 NR1A1 THRA1 THRA2;ARC205 CRSP1 CRSP200 DRIP205 DRIP230 PBP PPARBP PPARGBP RB18A TRAP220 TRIP2;ARC240 CAGH45 HOPA KIAA0192 TNRC11 TRAP230;ARC77 CRSP6 DRIP77 DRIP80 TRAP80;BCLAF2 TRAP150;DRIP92 THRAP5
67	AP4 adaptor complex	Human	None	brain	O00189;Q9UPM8;Q9Y587;Q9Y6B7	9179;23431;11154;10717	MI:0019-coimmunoprecipitation	GO:0006886;GO:0006605;GO:0015031;GO:0005515;GO:0006892;GO:0006897;GO:0030133;GO:0005794;GO:0016192	intracellular protein transport;protein targeting;protein transport;protein binding;post-Golgi vesicle-mediated transport;endocytosis;transport vesicle;Golgi apparatus;vesicle-mediated transport	14.04;20.01.10;16.01;20.09.07.06;20.09.18.09.01;70.09;70.08;20.09.07	protein targeting, sorting and translocation;protein transport;protein binding;post Golgi transport;endocytosis;intracellular transport vesicles;Golgi;vesicular transport (Golgi network, etc.)	10436028	Adaptor protein complexes (APs) function as vesicle coat components in different membrane traffic pathways.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	AP-4 complex subunit mu-1;AP-4 complex subunit epsilon-1;AP-4 complex subunit sigma-1;AP-4 complex subunit beta-1	AP4M1;AP4E1;AP4S1;AP4B1	MUARP2;None;None;None
68	BCDX2 complex	Human	RAD51B-RAD51C-RAD51D-XRCC2 complex	in vitro	O15315;O43502;O43543;O75771	5890;5889;7516;5892	MI:0004-affinity chromatography technology;MI:0019-coimmunoprecipitation;MI:0027-cosedimentation	GO:0006281;GO:0006310;GO:0003677;GO:0005524;GO:0006974;GO:0005634	DNA repair;DNA recombination;DNA binding;ATP binding;cellular response to DNA damage stimulus;nucleus	10.01.05.01;10.01.05.03;16.03.01;16.19.03;32.01.09;70.10	DNA repair;DNA recombination;DNA binding;ATP binding;DNA damage response;nucleus	15141025	None	None	The subunits from human of AP1 adaptor complex were expressed in E.coli and purified for the further experiments (PMID:15141025).	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA repair protein RAD51 homolog 2;DNA repair protein RAD51 homolog 3;DNA repair protein XRCC2;DNA repair protein RAD51 homolog 4	RAD51B;RAD51C;XRCC2;RAD51D	RAD51L1 REC2;RAD51L2;None;RAD51L3
72	R/M complex (RAD50-MRE11 complex)	Human	None	HeLa cells	P49959;Q92878	4361;10111	MI:0071-molecular sieving	GO:0006281;GO:0003677;GO:0006974;GO:0051276;GO:0005634	DNA repair;DNA binding;cellular response to DNA damage stimulus;chromosome organization;nucleus	10.01.05.01;16.03.01;32.01.09;42.10.03;70.10	DNA repair;DNA binding;DNA damage response;organization of chromosome structure;nucleus	9651580	Mre11 by itself has 3' to 5' exonuclease activity that is increased when Mre11 is in a complex with Rad50.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Double-strand break repair protein MRE11;DNA repair protein RAD50	MRE11;RAD50	HNGS1 MRE11A;None
74	HOMER3-IP3R-TRPC1 complex	Human	HOMER3-ITPR3-TRPC1 complex	HEK 293 cells	P48995;Q14573;Q9NSC5	7220;3710;9454	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0008324;GO:0006812;GO:0005216;GO:0023052;GO:0005886	cation transmembrane transporter activity;cation transport;ion channel activity;signaling;plasma membrane	20.01.01.01;20.03.01.01;30.01;70.02	cation transport (H+, Na+, K+, Ca2+ , NH4+, etc.);ion channels;cellular signalling;eukaryotic plasma membrane / membrane attached	14505576	An adaptor protein, termed Homer, facilitates a physical association between TRPC1 and the IP(3)R that is required for the TRP channel to respond to signals. The TRPC1-Homer-IP(3)R complex is dynamic and its disassembly parallels TRPC1 channel activation. Homer's action depends on its ability to crosslink and is blocked by the dominant-negative immediate early gene form, H1a. Since H1a is transcriptionally regulated by cellular activity, this mechanism can affect both short and long-term regulation of TRPC1 function. TRPC1 is present at the plasma membrane.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Short transient receptor potential channel 1;Inositol 1,4,5-trisphosphate receptor type 3;Homer protein homolog 3	TRPC1;ITPR3;HOMER3	TRP1;None;None
81	Ubiquitin E3 ligase (SKP1A, FBXW8, CUL7, RBX1)	Human	Cul7-Rbx1-Skp1-F-Fbx29 complex	293FR cells (generated by authors)	P62877;P63208;Q14999;Q8N3Y1	9978;6500;9820;26259	MI:0004-affinity chromatography technology	GO:0016567;GO:0006511	protein ubiquitination;ubiquitin-dependent protein catabolic process	14.07.05;14.13.01.01	modification by ubiquitination, deubiquitination;proteasomal degradation (ubiquitin/proteasomal pathway)	12481031	Ubiquitin E3 ligases covalently attach ubiquitin to a lysine residue on a target protein. Polyubiquitination marks proteins for degradation by the proteasome.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase RBX1;S-phase kinase-associated protein 1;Cullin-7;F-box/WD repeat-containing protein 8	RBX1;SKP1;CUL7;FBXW8	RNF75 ROC1;EMC19 OCP2 SKP1A TCEB1L;KIAA0076;FBW6 FBW8 FBX29 FBXO29 FBXW6
86	NUMAC complex (nucleosomal methylation activator complex)	Human	CARM1-associated complex	None	O14497;P51532;P60709;Q12824;Q86X55;Q8TAQ2;Q92922;Q969G3;Q96GM5;Q96KG9	8289;6597;60;6598;10498;6601;6599;6605;6602;57410	MI:0004-affinity chromatography technology;MI:0029-cosedimentation through density gradient	GO:0006265;GO:0045893;GO:0018126;GO:0006479;GO:0003677;GO:0009755;GO:0023052;GO:0051276;GO:0005634	DNA topological change;positive regulation of DNA-templated transcription;protein hydroxylation;protein methylation;DNA binding;hormone-mediated signaling pathway;signaling;chromosome organization;nucleus	10.01.09.05;11.02.03.04.01;14.07.09;16.03.01;30.01.09.08;30.01;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription activation;posttranslational modification of amino acids (e.g. hydroxylation, methylation);DNA binding;hormone mediated signal transduction;cellular signalling;organization of chromosome structure;nucleus	14729568	In the NUMAC complex, the methylase, CARM1, acquires the ability to covalently modify nucleosomal histones.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	AT-rich interactive domain-containing protein 1A;Transcription activator BRG1;Actin, cytoplasmic 1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1;Histone-arginine methyltransferase CARM1;SWI/SNF complex subunit SMARCC2;SWI/SNF complex subunit SMARCC1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1;N-terminal kinase-like protein	ARID1A;SMARCA4;ACTB;SMARCB1;CARM1;SMARCC2;SMARCC1;SMARCE1;SMARCD1;SCYL1	BAF250 BAF250A C1orf4 OSA1 SMARCF1;BAF190A BRG1 SNF2B SNF2L4;None;BAF47, INI1, SNF5L1;PRMT4;BAF170;BAF155;BAF57;BAF60A;CVAK90 GKLP NTKL TAPK TEIF TRAP
87	Nup 107-160 subcomplex	Human	NPC subcomplex	HeLa cells	P52948;P55735;P57740;Q12769;Q8NFH3;Q8NFH4;Q8WUM0;Q96EE3;Q9BW27	4928;6396;57122;23279;348995;79023;55746;81929;79902	MI:0019-coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0015031;GO:0051169;GO:0000775	protein transport;nuclear transport;chromosome, centromeric region	20.01.10;20.09.01;70.10.04	protein transport;nuclear transport;centromere / kinetochore	15146057	All trafficking of macromolecules between the cytoplasm and the nucleus occurs through nuclear pore complexes (NPCs), which are supramolecular assemblies at points of fusion between the inner and outer nuclear membranes. NPCs are composed of an eightfold symmetric spoke-ring complex, cytoplasmic fibers, and a nuclear basket.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Nuclear pore complex protein Nup98-Nup96;Protein SEC13 homolog;Nuclear pore complex protein Nup107;Nuclear pore complex protein Nup160;Nucleoporin Nup43;Nucleoporin Nup37;Nuclear pore complex protein Nup133;Nucleoporin SEH1;Nuclear pore complex protein Nup85	NUP98;SEC13;NUP107;NUP160;NUP43;NUP37;NUP133;SEH1L;NUP85	ADAR2;D3S1231E SEC13A SEC13L1 SEC13R;None;KIAA0197 NUP120;None;None;None;SEC13L SEH1;NUP75 PCNT1
91	FA complex (Fanconi anemia complex), cytoplasmic	Human	None	HeLa cells	O15287;O15360;Q00597;Q9NPI8	2189;2175;2176;2188	MI:0004-affinity chromatography technology;MI:0069-mass spectrometry studies of complexes	GO:0016567;GO:0006974;GO:0005737	protein ubiquitination;cellular response to DNA damage stimulus;cytoplasm	14.07.05;32.01.09;70.03	modification by ubiquitination, deubiquitination;DNA damage response;cytoplasm	15082718	None	FA complex is involved in Fanconi anemia (FA) disease (PMID:15082718).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Fanconi anemia group G protein;Fanconi anemia group A protein;Fanconi anemia group C protein;Fanconi anemia group F protein	FANCG;FANCA;FANCC;FANCF	XRCC9;FAA FACA FANCH;FAC FACC;None
92	CD28-transactivation complex	Human	None	None	P10747;P19338	940;4691	MI:0004-affinity chromatography technology	GO:0006352;GO:2001141;GO:0006355;GO:0005634	DNA-templated transcription initiation;regulation of RNA biosynthetic process;regulation of DNA-templated transcription;nucleus	11.02.03.01.01;11.02.03.04;70.10	transcription initiation;transcriptional control;nucleus	12324461	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	T-cell-specific surface glycoprotein CD28;Nucleolin	CD28;NCL	None;None
93	Anaphase-promoting complex	Human	APC; cyclosome	None	P30260;Q13042;Q9H1A4;Q9UJX2;Q9UJX3;Q9UJX4;Q9UJX5;Q9UJX6	996;8881;64682;8697;51434;51433;29945;29882	MI:0019-coimmunoprecipitation	GO:0000278;GO:0051726;GO:0016567;GO:0005515;GO:0005634	mitotic cell cycle;regulation of cell cycle;protein ubiquitination;protein binding;nucleus	10.03.01.01;10.03.01;14.07.05;16.01;70.10	mitotic cell cycle;mitotic cell cycle and cell cycle control;modification by ubiquitination, deubiquitination;protein binding;nucleus	9469815	The initiation of anaphase and exit from mitosis depend on a multi-subunit ubiquitination complex called the anaphase-promoting complex (APC)1 or cyclosome. The APC ubiquitinates proteins such as Pds1 in budding yeast and Cut2 in fission yeast whose subsequent degradation by the 26 S proteasome is essential for the initiation of sister chromatid separation at the metaphase-anaphase transition. Later in anaphase and telophase the APC promotes the inactivation of the mitotic cyclin-dependent protein kinase 1 by ubiquitinating its activating subunit cyclin B.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cell division cycle protein 27 homolog;Cell division cycle protein 16 homolog;Anaphase-promoting complex subunit 1;Cell division cycle protein 23 homolog;Anaphase-promoting complex subunit 7;Anaphase-promoting complex subunit 5;Anaphase-promoting complex subunit 4;Anaphase-promoting complex subunit 2	CDC27;CDC16;ANAPC1;CDC23;ANAPC7;ANAPC5;ANAPC4;ANAPC2	ANAPC3 D0S1430E D17S978E;ANAPC6;TSG24;ANAPC8;APC7;APC5;APC4;APC2 KIAA1406
95	Ku antigen-NARG1 complex	Human	OCFRE-binding complex	MC3T3-E1 cells	P12956;P13010;Q9BXJ9	2547;7520;80155	MI:0004-affinity chromatography technology	GO:2001141;GO:0006355;GO:0003677	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;DNA binding	11.02.03.04;16.03.01	transcriptional control;DNA binding	12145306	This complex regulates osteocalcin gene expression.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	X-ray repair cross-complementing protein 6;X-ray repair cross-complementing protein 5;N-alpha-acetyltransferase 15, NatA auxiliary subunit	XRCC6;XRCC5;NAA15	G22P1;G22P2;GA19 NARG1 NATH TBDN100
96	Anaphase-promoting complex	Human	APC; cyclosome	None	P30260;Q13042;Q9H1A4;Q9UJX2;Q9UJX3;Q9UJX4;Q9UJX5;Q9UJX6;Q9UM13	996;8881;64682;8697;51434;51433;29945;29882;10393	MI:0019-coimmunoprecipitation	GO:0000278;GO:0051726;GO:0016567;GO:0005515;GO:0005634;GO:0006511	mitotic cell cycle;regulation of cell cycle;protein ubiquitination;protein binding;nucleus;ubiquitin-dependent protein catabolic process	10.03.01.01;10.03.01;14.07.05;16.01;70.10;14.13.01.01	mitotic cell cycle;mitotic cell cycle and cell cycle control;modification by ubiquitination, deubiquitination;protein binding;nucleus;proteasomal degradation (ubiquitin/proteasomal pathway)	10318877	The initiation of anaphase and exit from mitosis depend on a multi-subunit ubiquitination complex called the anaphase-promoting complex (APC)1 or cyclosome. The APC ubiquitinates proteins such as Pds1 in budding yeast and Cut2 in fission yeast whose subsequent degradation by the 26 S proteasome is essential for the initiation of sister chromatid separation at the metaphase-anaphase transition. Later in anaphase and telophase the APC promotes the inactivation of the mitotic cyclin-dependent protein kinase 1 by ubiquitinating its activating subunit cyclin B.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cell division cycle protein 27 homolog;Cell division cycle protein 16 homolog;Anaphase-promoting complex subunit 1;Cell division cycle protein 23 homolog;Anaphase-promoting complex subunit 7;Anaphase-promoting complex subunit 5;Anaphase-promoting complex subunit 4;Anaphase-promoting complex subunit 2;Anaphase-promoting complex subunit 10	CDC27;CDC16;ANAPC1;CDC23;ANAPC7;ANAPC5;ANAPC4;ANAPC2;ANAPC10	ANAPC3 D0S1430E D17S978E;ANAPC6;TSG24;ANAPC8;APC7;APC5;APC4;APC2 KIAA1406;APC10
98	p300-MDM2-p53 protein complex	Human	None	None	P04637;Q00987;Q09472	7157;4193;2033	MI:0091-chromatography technology	GO:2001141;GO:0006355;GO:0030234;GO:0050790;GO:0005634	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;enzyme regulator activity;regulation of catalytic activity;nucleus	11.02.03.04;18.02.01;70.10	transcriptional control;enzymatic activity regulation / enzyme regulator;nucleus	11070080	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cellular tumor antigen p53;E3 ubiquitin-protein ligase Mdm2;Histone acetyltransferase p300	TP53;MDM2;EP300	P53;None;P300
100	hNURF complex	Human	None	None	P28370;Q09028;Q12830;Q16576	6594;5928;2186;5931	MI:0071-molecular sieving;MI:0226-ion exchange chromatography	GO:0006265;GO:2001141;GO:0006355;GO:0022008;GO:0048699;GO:0051276;GO:0030182;GO:0005634	DNA topological change;regulation of RNA biosynthetic process;regulation of DNA-templated transcription;neurogenesis;generation of neurons;chromosome organization;neuron differentiation;nucleus	10.01.09.05;11.02.03.04;41.05.13;42.10.03;43.03.13;70.10	DNA conformation modification (e.g. chromatin);transcriptional control;neurogenesis;organization of chromosome structure;neuron;nucleus	14609955	NURF is a member of the ISWI-containing chromatin remodeling complexes.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Probable global transcription activator SNF2L1;Histone-binding protein RBBP4;Nucleosome-remodeling factor subunit BPTF;Histone-binding protein RBBP7	SMARCA1;RBBP4;BPTF;RBBP7	SNF2L SNF2L1;RBAP48;FAC1 FALZ;RBAP46
103	RNA polymerase II holoenzyme complex	Human	None	HeLa cells	O15514;P13984;P18074;P19387;P19388;P19447;P20226;P24928;P29083;P29084;P30876;P32780;P35269;P36954;P52434;P52435;P53803;P61218;P62487;P62875;Q00403;Q13888;Q13889;Q92759	5433;2963;2068;5432;5434;2071;6908;5430;2960;2961;5431;2965;2962;5438;5437;5439;5440;5435;5436;5441;2959;2966;2967;2968	MI:0004-affinity chromatography technology	GO:0006351;GO:0003677;GO:0005634	DNA-templated transcription;DNA binding;nucleus	11;16.03.01;70.10	TRANSCRIPTION;DNA binding;nucleus	9305922	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA-directed RNA polymerase II subunit RPB4;General transcription factor IIF subunit 2;General transcription and DNA repair factor IIH helicase subunit XPD;DNA-directed RNA polymerase II subunit RPB3;DNA-directed RNA polymerases I, II, and III subunit RPABC1;General transcription and DNA repair factor IIH helicase subunit XPB;TATA-box-binding protein;DNA-directed RNA polymerase II subunit RPB1;General transcription factor IIE subunit 1;Transcription initiation factor IIE subunit beta;DNA-directed RNA polymerase II subunit RPB2;General transcription factor IIH subunit 1;General transcription factor IIF subunit 1;DNA-directed RNA polymerase II subunit RPB9;DNA-directed RNA polymerases I, II, and III subunit RPABC3;DNA-directed RNA polymerase II subunit RPB11-a;DNA-directed RNA polymerases I, II, and III subunit RPABC4;DNA-directed RNA polymerases I, II, and III subunit RPABC2;DNA-directed RNA polymerase II subunit RPB7;DNA-directed RNA polymerases I, II, and III subunit RPABC5;Transcription initiation factor IIB;General transcription factor IIH subunit 2;General transcription factor IIH subunit 3;General transcription factor IIH subunit 4	POLR2D;GTF2F2;ERCC2;POLR2C;POLR2E;ERCC3;TBP;POLR2A;GTF2E1;GTF2E2;POLR2B;GTF2H1;GTF2F1;POLR2I;POLR2H;POLR2J;POLR2K;POLR2F;POLR2G;POLR2L;GTF2B;GTF2H2;GTF2H3;GTF2H4	None;RAP30;XPD XPDC;None;None;XPB XPBC;GTF2D1 TF2D TFIID;POLR2;TF2E1;TF2E2;None;BTF2;RAP74;None;None;POLR2J1;None;POLRF;RPB7;None;TF2B TFIIB;BTF2P44;None;None
104	RNA polymerase II core complex	Human	None	HeLa cells	O15514;P19387;P19388;P24928;P30876;P36954;P52434;P52435;P53803;P61218;P62487;P62875	5433;5432;5434;5430;5431;5438;5437;5439;5440;5435;5436;5441	MI:0004-affinity chromatography technology	GO:0006351;GO:0003677;GO:0005634	DNA-templated transcription;DNA binding;nucleus	11;16.03.01;70.10	TRANSCRIPTION;DNA binding;nucleus	9852112	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA-directed RNA polymerase II subunit RPB4;DNA-directed RNA polymerase II subunit RPB3;DNA-directed RNA polymerases I, II, and III subunit RPABC1;DNA-directed RNA polymerase II subunit RPB1;DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase II subunit RPB9;DNA-directed RNA polymerases I, II, and III subunit RPABC3;DNA-directed RNA polymerase II subunit RPB11-a;DNA-directed RNA polymerases I, II, and III subunit RPABC4;DNA-directed RNA polymerases I, II, and III subunit RPABC2;DNA-directed RNA polymerase II subunit RPB7;DNA-directed RNA polymerases I, II, and III subunit RPABC5	POLR2D;POLR2C;POLR2E;POLR2A;POLR2B;POLR2I;POLR2H;POLR2J;POLR2K;POLR2F;POLR2G;POLR2L	None;None;None;POLR2;None;None;None;POLR2J1;None;POLRF;RPB7;None
107	TFIIH transcription factor complex	Human	None	HeLa cells	P18074;P19447;P32780;P50613;P51946;P51948;Q13888;Q13889;Q92759	2068;2071;2965;1022;902;4331;2966;2967;2968	MI:0004-affinity chromatography technology	GO:0006281;GO:0007049;GO:0006355;GO:0005634	DNA repair;cell cycle;regulation of DNA-templated transcription;nucleus	10.01.05.01;10.03;11.02.03.04;70.10	DNA repair;cell cycle;transcriptional control;nucleus	9852112	Transcription factor IIH (TFIIH) is a multisubunit complex required for transcription and for DNA nucleotide excision repair.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	General transcription and DNA repair factor IIH helicase subunit XPD;General transcription and DNA repair factor IIH helicase subunit XPB;General transcription factor IIH subunit 1;Cyclin-dependent kinase 7;Cyclin-H;CDK-activating kinase assembly factor MAT1;General transcription factor IIH subunit 2;General transcription factor IIH subunit 3;General transcription factor IIH subunit 4	ERCC2;ERCC3;GTF2H1;CDK7;CCNH;MNAT1;GTF2H2;GTF2H3;GTF2H4	XPD XPDC;XPB XPBC;BTF2;CAK CAK1 CDKN7 MO15 STK1;None;CAP35 MAT1 RNF66;BTF2P44;None;None
112	Prefoldin complex	Human	PFD complex	human PFD was assembled from individual subunits of PFD	O15212;O60925;P61758;Q99471;Q9NQP4;Q9UHV9	10471;5201;7411;5204;5203;5202	MI:0040-electron microscopy;MI:0071-molecular sieving;MI:0413-electrophoretic mobility shift assay	GO:0050821;GO:0006457;GO:0007010;GO:0030036;GO:0016272	protein stabilization;protein folding;cytoskeleton organization;actin cytoskeleton organization;prefoldin complex	14.01;42.04;42.04.03	protein folding and stabilization;cytoskeleton/structural proteins;actin cytoskeleton	12456645	The biogenesis of the cytoskeletal proteins actin and tubulin involves interaction of nascent chains of each of the two proteins with the oligomeric protein prefoldin(PFD) and their subsequent transfer to the cytosolic chaperonin CCT (chaperonin containing TCP-1). PFD exists as a more complex oligomer assembled from six different proteins.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Prefoldin subunit 6;Prefoldin subunit 1;Prefoldin subunit 3;Prefoldin subunit 5;Prefoldin subunit 4;Prefoldin subunit 2	PFDN6;PFDN1;VBP1;PFDN5;PFDN4;PFDN2	HKE2 PFD6;PFD1;PFDN3;MM1 PFD5;PFD4;PFD2
114	SNAPc (small nuclear RNA-activating protein) complex	Human	PTF	None	O75971;Q13487;Q16533;Q5SXM2;Q92966	10302;6618;6617;6621;6619	MI:0019-coimmunoprecipitation	GO:2001141;GO:0006355;GO:0005515;GO:0003677;GO:0005634	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;protein binding;DNA binding;nucleus	11.02.03.04;16.01;16.03.01;70.10	transcriptional control;protein binding;DNA binding;nucleus	11056176	Additional information about the constituents of the SNAPc complex is given in PMID:7715707 and PMID:9732265.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	snRNA-activating protein complex subunit 5;snRNA-activating protein complex subunit 2;snRNA-activating protein complex subunit 1;snRNA-activating protein complex subunit 4;snRNA-activating protein complex subunit 3	SNAPC5;SNAPC2;SNAPC1;SNAPC4;SNAPC3	SNAP19;SNAP45;SNAP43;SNAP190;SNAP50
115	Polycomb repressive complex 1 (PRC1, hPRC-H)	Human	None	None	O00257;O60264;P0DMV8;P35226;P78364;Q06587;Q14781;Q8IXK0;Q8NDX5;Q96GD3;Q99496;Q9HC52	8535;8467;3303;648;1911;6015;84733;1912;80012;22955;6045;57332	MI:0004-affinity chromatography technology	GO:0006265;GO:0045892;GO:0032774;GO:0018126;GO:0006479;GO:0051276;GO:0005634	DNA topological change;negative regulation of DNA-templated transcription;RNA biosynthetic process;protein hydroxylation;protein methylation;chromosome organization;nucleus	10.01.09.05;11.02.03.04.03;11.02;14.07.09;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription repression;RNA synthesis;posttranslational modification of amino acids (e.g. hydroxylation, methylation);organization of chromosome structure;nucleus	12167701	Polycomb repressive complexes are required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones. hPRC-H apparently represents not a single complex but rather a mixture of highly related complexes, here exemplified by the M33F and Bmi1F M2 eluates. The identified beta-tubulin may be a contaminant, it needs more characterization.	None	Since the authors did not specify HSP70, we used isoform HSPA1A.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 SUMO-protein ligase CBX4;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5;Heat shock 70 kDa protein 1A;Polycomb complex protein BMI-1;Polyhomeotic-like protein 1;E3 ubiquitin-protein ligase RING1;Chromobox protein homolog 2;Polyhomeotic-like protein 2;Polyhomeotic-like protein 3;Polycomb protein SCMH1;E3 ubiquitin-protein ligase RING2;Chromobox protein homolog 8	CBX4;SMARCA5;HSPA1A;BMI1;PHC1;RING1;CBX2;PHC2;PHC3;SCMH1;RNF2;CBX8	None;SNF2H, WCRF135;HSP72 HSPA1 HSX70;PCGF4 RNF51;EDR1 PH1;RNF1;None;EDR2 PH2;EDR3 PH3;None;BAP1 DING HIPI3 RING1B;PC3 RC1
116	Polycomb repressive complex 1 (PRC1, hPRC-H)	Human	None	None	O00257;O60264;P0DMV8;P25490;P35226;P78364;Q06587;Q14781;Q8IXK0;Q8NDX5;Q96GD3;Q99496;Q9HC52	8535;8467;3303;7528;648;1911;6015;84733;1912;80012;22955;6045;57332	MI:0004-affinity chromatography technology	GO:0006265;GO:0045892;GO:0032774;GO:0018126;GO:0006479;GO:0051276;GO:0005634	DNA topological change;negative regulation of DNA-templated transcription;RNA biosynthetic process;protein hydroxylation;protein methylation;chromosome organization;nucleus	10.01.09.05;11.02.03.04.03;11.02;14.07.09;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription repression;RNA synthesis;posttranslational modification of amino acids (e.g. hydroxylation, methylation);organization of chromosome structure;nucleus	12167701	Polycomb repressive complexes are required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones. hPRC-H apparently represents not a single complex but rather a mixture of highly related complexes, here exemplified by the Hi-Trap S eluate. The identified beta-tubulin may be a contaminant, it needs more characterization.	None	Since the authors did not specify HSP70, we used isoform HSPA1A	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 SUMO-protein ligase CBX4;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5;Heat shock 70 kDa protein 1A;Transcriptional repressor protein YY1;Polycomb complex protein BMI-1;Polyhomeotic-like protein 1;E3 ubiquitin-protein ligase RING1;Chromobox protein homolog 2;Polyhomeotic-like protein 2;Polyhomeotic-like protein 3;Polycomb protein SCMH1;E3 ubiquitin-protein ligase RING2;Chromobox protein homolog 8	CBX4;SMARCA5;HSPA1A;YY1;BMI1;PHC1;RING1;CBX2;PHC2;PHC3;SCMH1;RNF2;CBX8	None;SNF2H, WCRF135;HSP72 HSPA1 HSX70;INO80S;PCGF4 RNF51;EDR1 PH1;RNF1;None;EDR2 PH2;EDR3 PH3;None;BAP1 DING HIPI3 RING1B;PC3 RC1
117	GPR56-CD81-Galpha(q/11)-Gbeta complex	Human	None	Brij 96 lysate of HEK 293 cells	P29992;P50148;P60033;P62873;Q9Y653	2767;2776;975;2782;9289	MI:0019-coimmunoprecipitation	GO:0007186	G protein-coupled receptor signaling pathway	30.05.02.24	G-protein coupled receptor signalling pathway	15004227	The central role of CD81 (and CD9 when present) suggests possible scaffolding functions for CD81 and CD9 in GPR56 signaling.	None	The Gbeta peptide identified by mass spectrometry is a sequence common to beta subunits 1-4, and the anti-Gbeta antiserum recognizes all four subunits. Since the authors did not specify Gbeta peptide, we used isoform GNB1.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein subunit alpha-11;Guanine nucleotide-binding protein G(q) subunit alpha;CD81 antigen;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;Adhesion G-protein coupled receptor G1	GNA11;GNAQ;CD81;GNB1;ADGRG1	GA11;GAQ;TAPA1 TSPAN28;None;GPR56 TM7LN4 TM7XN1
118	GPI-GnT activity complex	Human	None	JY25 cells	P37287;Q14442;Q92535;Q9BRB3	5277;5283;5279;9091	MI:0004-affinity chromatography technology	GO:0006644;GO:0008654;GO:0009395;GO:0005783	phospholipid metabolic process;phospholipid biosynthetic process;phospholipid catabolic process;endoplasmic reticulum	01.06.02.01;70.07	phospholipid metabolism;endoplasmic reticulum	9463366	This protein complex has GPI-GlcNAc transferase (GPI-GnT) activity in vitro.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Phosphatidylinositol N-acetylglucosaminyltransferase subunit A;Phosphatidylinositol N-acetylglucosaminyltransferase subunit H;Phosphatidylinositol N-acetylglucosaminyltransferase subunit C;Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q	PIGA;PIGH;PIGC;PIGQ	None;None;GPI2;GPI1
120	Lymphotoxin beta receptor complex	Human	None	COS7 cells	P01374;P36941;Q06643	4049;4055;4050	MI:0019-coimmunoprecipitation	GO:0007166;GO:0006915	cell surface receptor signaling pathway;apoptotic process	30.05;40.10.02	transmembrane signal transduction;apoptosis (type I programmed cell death)	9122217	The binding of heterotrimeric lymphotoxin, LT alpha1 beta2, to the LTbeta receptor (LTbeta R), a member of the tumor necrosis factor receptor (TNFR) superfamily, induces nuclear factor kappaB (NF-kappaB) activation and cell death in HT29 adenocarcinoma cells.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Lymphotoxin-alpha;Tumor necrosis factor receptor superfamily member 3;Lymphotoxin-beta	LTA;LTBR;LTB	TNFB TNFSF1;D12S370 TNFCR TNFR3 TNFRSF3;TNFC TNFSF3
123	Rnase/Mrp complex	Human	None	in vitro	O75817;O75818;O95059;O95707;P78345;P78346;Q969H6;Q99575;Q9BUL9;Q9H633	10248;10799;11102;10775;10557;10556;51367;10940;54913;79897	MI:0096-pull down	GO:0006401;GO:0006364;GO:0003723;GO:0005634	RNA catabolic process;rRNA processing;RNA binding;nucleus	01.03.16.01;11.04.01;16.03.03;70.10	RNA degradation;rRNA processing;RNA binding;nucleus	15096576	RNase MRP is involved in the processing of pre-rRNA and the generation of RNA primers for mitochondrial DNA replication.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Ribonuclease P protein subunit p20;Ribonuclease P protein subunit p40;Ribonuclease P protein subunit p14;Ribonuclease P protein subunit p29;Ribonuclease P protein subunit p38;Ribonuclease P protein subunit p30;Ribonuclease P/MRP protein subunit POP5;Ribonucleases P/MRP protein subunit POP1;Ribonuclease P protein subunit p25;Ribonuclease P protein subunit p21	POP7;RPP40;RPP14;POP4;RPP38;RPP30;POP5;POP1;RPP25;RPP21	RPP20;RNASEP1;None;RPP29;None;RNASEP2;None;KIAA0061;None;C6orf135 CAT60
126	CCT complex (chaperonin containing TCP1 complex)	Human	CCT micro-complex	293T cells	P17987;P40227;P48643;P49368;P50990;P50991;P78371;Q99832	6950;908;22948;7203;10694;10575;10576;10574	MI:0029-cosedimentation through density gradient;MI:0047-far western blotting;MI:0091-chromatography technology	GO:0050821;GO:0006457;GO:0005524;GO:0005737	protein stabilization;protein folding;ATP binding;cytoplasm	14.01;16.19.03;70.03	protein folding and stabilization;ATP binding;cytoplasm	9250675	The chaperonins are a family of molecular chaperones involved in protein folding, assembly and transport. The chaperonin-containing TCP-1 (CCT) is abundant in eukaryotic cytosol. CCT micro-complexes have mol. wts ranging from 120 to 250 kDa and are present in cells at lower abundance (<5%) as compared with intact CCT.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	T-complex protein 1 subunit alpha;T-complex protein 1 subunit zeta;T-complex protein 1 subunit epsilon;T-complex protein 1 subunit gamma;T-complex protein 1 subunit theta;T-complex protein 1 subunit delta;T-complex protein 1 subunit beta;T-complex protein 1 subunit eta	TCP1;CCT6A;CCT5;CCT3;CCT8;CCT4;CCT2;CCT7	CCT1 CCTA;CCT6 CCTZ;CCTE KIAA0098;CCTG TRIC5;C21orf112 CCTQ KIAA0002;CCTD SRB;99D8.1 CCTB;CCTH NIP7-1
127	NDC80 kinetochore complex	Human	None	HeLa Tet-On cells	O14777;Q8NBT2;Q9BZD4;Q9HBM1	10403;147841;83540;57405	MI:0019-coimmunoprecipitation	GO:0000278;GO:0007059;GO:0000775	mitotic cell cycle;chromosome segregation;chromosome, centromeric region	10.03.01.01;10.03.04.05;70.10.04	mitotic cell cycle;chromosome segregation/division;centromere / kinetochore	14699129	Components of the conserved NDC80 complex are required for chromosome congression, and their disruption results in mitotic arrest accompanied by multiple spindle aberrations.hSPC25 is an essential kinetochore component that plays a significant role in proper execution of mitotic events.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Kinetochore protein NDC80 homolog;Kinetochore protein Spc24;Kinetochore protein Nuf2;Kinetochore protein Spc25	NDC80;SPC24;NUF2;SPC25	HEC HEC1 KNTC2;SPBC24;CDCA1 NUF2R;SPBC25
129	PIDDsome complex	Human	None	293T cells	P42575;P78560;Q9HB75	835;8738;55367	MI:0019-coimmunoprecipitation	GO:0006919;GO:0006915	activation of cysteine-type endopeptidase activity involved in apoptotic process;apoptotic process	40.10.02.02.02;40.10.02	caspase activation;apoptosis (type I programmed cell death)	15073321	None	PIDDsome is involved in caspase-2 dependent TSA-induced cell death in prostate cancer cell lines (PMID:17110788).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Caspase-2;Death domain-containing protein CRADD;p53-induced death domain-containing protein 1	CASP2;CRADD;PIDD1	ICH1 NEDD2;RAIDD;LRDD PIDD
138	Telomere-associated protein complex	Human	Telosome complex; TRF1-TIN2 complex; Shelterin	HeLa cells	P54274;Q15554;Q96AP0;Q9BSI4;Q9NUX5;Q9NYB0	7013;7014;65057;26277;25913;54386	MI:0071-molecular sieving	GO:0003677;GO:0051276;GO:0005634;GO:0000723;GO:0019048;GO:0009615	DNA binding;chromosome organization;nucleus;telomere maintenance;modulation by virus of host process;response to virus	16.03.01;42.10.03;70.10	DNA binding;organization of chromosome structure;nucleus	15383534	TIN2 binds TRF2 directly, thereby tethering TRF2 to the TRF1 complex. The Shelterin complex protects telomeres from degradation and is therefore responsible for telomere maintenance (PMID:15383534, 32320442). Human herpesviruses 6A and 6B are able to integrate their genome into host chromosomes within the host telomeres. Components of the host shelterin protein complex, including TERF1 and TERF2 are recruited to viral telomeric sequences during infection to improve chromosomal integration. (PMID:32320442)	This complex gained particular interest in melanoma genetics as germline variants were found in 3 shelterin genes in melanoma prone families: POT1, ACD and TERF2IP (PMID:15181449).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Telomeric repeat-binding factor 1;Telomeric repeat-binding factor 2;Adrenocortical dysplasia protein homolog;TERF1-interacting nuclear factor 2;Protection of telomeres protein 1;Telomeric repeat-binding factor 2-interacting protein 1	TERF1;TERF2;ACD;TINF2;POT1;TERF2IP	PIN2 TRBF1 TRF TRF1;TRBF2, TRF2;PIP1 PTOP TINT1 TPP1;TIN2;None;DRIP5, RAP1
140	E-box sequence-binding complex	Human	Bex2 protein complex	HeLa cells	P25791;Q02577;Q86U70;Q9BXY8	4005;4808;8861;None	MI:0019-coimmunoprecipitation	GO:2001141;GO:0006355;GO:0022008;GO:0048699;GO:0005634	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;neurogenesis;generation of neurons;nucleus	11.02.03.04;41.05.13;70.10	transcriptional control;neurogenesis;nucleus	16314316	This complex may help to understand the molecular mechanisms by which hBex2 plays a role in transcriptional regulation in the brain during neurodevelopment.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Rhombotin-2;Helix-loop-helix protein 2;LIM domain-binding protein 1;Protein BEX2	LMO2;NHLH2;LDB1;BEX2	RBTN2 RBTNL1 RHOM2 TTG2;BHLHA34 HEN2 KIAA0490;CLIM2;None
142	CD147-gamma-secretase complex	Human	CD147-gamma-secretase complex (APH-1a, PS-1, PEN-2, NCT variant)	HeLa cell	P35613;P49768;Q92542;Q96BI3;Q9NZ42	682;5663;23385;51107;55851	MI:0019-coimmunoprecipitation	GO:0016485;GO:0023052;GO:0005886;GO:0005794	protein processing;signaling;plasma membrane;Golgi apparatus	14.07.11;30.01;70.02;70.08	protein processing (proteolytic);cellular signalling;eukaryotic plasma membrane / membrane attached;Golgi	15890777	CD147 in gamma-secretase complex down-modulates the production of amyloid beta-peptides (PMID:15890777).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Basigin;Presenilin-1;Nicastrin;Gamma-secretase subunit APH-1A;Gamma-secretase subunit PEN-2	BSG;PSEN1;NCSTN;APH1A;PSENEN	None;AD3 PS1 PSNL1;KIAA0253;PSF;PEN2
143	APP695-APBB1-LRP1 complex	Human	APP695-FE65-LRP1 complex	HEK 293 cells	O00213;P05067-4;Q07954	322;None;4035	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0016485	protein processing	14.07.11	protein processing (proteolytic)	15115822	None	None	Splice variant 4 (P05067-4) of APP was shown to be subunit of the protein complex.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Amyloid beta precursor protein binding family B member 1;Isoform APP695 of Amyloid-beta precursor protein;Prolow-density lipoprotein receptor-related protein 1	APBB1;APP;LRP1	FE65 RIR;A4 AD1;A2MR APR
144	Gamma-BAR-AP1 complex	Human	None	HeLa cells	O43747;O75843;P56377;P61966;Q10567;Q63HQ0;Q96PC3;Q9BXS5;Q9Y6Q5	164;8906;8905;1174;162;55435;130340;8907;10053	MI:0018-two hybrid;MI:0019-coimmunoprecipitation	GO:0006886;GO:0006605;GO:0015031;GO:0016192;GO:0006900;GO:0016050;GO:0006897;GO:0030133	intracellular protein transport;protein targeting;protein transport;vesicle-mediated transport;vesicle budding from membrane;vesicle organization;endocytosis;transport vesicle	14.04;20.01.10;20.09.07;20.09.07.25;20.09.18.09.01;70.09	protein targeting, sorting and translocation;protein transport;vesicular transport (Golgi network, etc.);vesicle formation;endocytosis;intracellular transport vesicles	15775984	The isolation of AP1 adaptor complex was described in (PMID:9733768).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	AP-1 complex subunit gamma-1;AP-1 complex subunit gamma-like 2;AP-1 complex subunit sigma-2;AP-1 complex subunit sigma-1A;AP-1 complex subunit beta-1;AP-1 complex-associated regulatory protein;AP-1 complex subunit sigma-3;AP-1 complex subunit mu-1;AP-1 complex subunit mu-2	AP1G1;AP1G2;AP1S2;AP1S1;AP1B1;AP1AR;AP1S3;AP1M1;AP1M2	ADTG CLAPG1;None;None;AP19 CLAPS1;ADTB1 BAM22 CLAPB2;C4orf16;None;CLTNM;None
149	PBAF complex (Polybromo- and BAF containing complex)	Human	SWI/SNF complex B	KB cells	O96019;P51532;P60709;Q12824;Q68CP9;Q86U86;Q8TAQ2;Q92922;Q969G3;Q96GM5	86;6597;60;6598;196528;55193;6601;6599;6605;6602	MI:0004-affinity chromatography technology;MI:0019-coimmunoprecipitation	GO:0006338;GO:0005634;GO:0003677;GO:0006355	chromatin remodeling;nucleus;DNA binding;regulation of DNA-templated transcription	70.10;16.03.01;11.02.03.04	nucleus;DNA binding;transcriptional control	11078522	None	None	Since the authors did not specify Actin as well as Actin-like protein 6, we used isoform ACTB and isoform ACTL6A, respectively. At the time of annotation, the additional member BAF240 of the protein complex was not found in the UniProt database.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Actin-like protein 6A;Transcription activator BRG1;Actin, cytoplasmic 1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1;AT-rich interactive domain-containing protein 2;Protein polybromo-1;SWI/SNF complex subunit SMARCC2;SWI/SNF complex subunit SMARCC1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1	ACTL6A;SMARCA4;ACTB;SMARCB1;ARID2;PBRM1;SMARCC2;SMARCC1;SMARCE1;SMARCD1	BAF53 BAF53A INO80K;BAF190A BRG1 SNF2B SNF2L4;None;BAF47, INI1, SNF5L1;BAF200 KIAA1557;BAF180 PB1;BAF170;BAF155;BAF57;BAF60A
152	TFIIE complex	Human	None	None	P29083;P29084	2960;2961	MI:0019-coimmunoprecipitation	GO:0006352;GO:2001141;GO:0006355;GO:0005634	DNA-templated transcription initiation;regulation of RNA biosynthetic process;regulation of DNA-templated transcription;nucleus	11.02.03.01.01;11.02.03.04;70.10	transcription initiation;transcriptional control;nucleus	9836642	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	General transcription factor IIE subunit 1;Transcription initiation factor IIE subunit beta	GTF2E1;GTF2E2	TF2E1;TF2E2
153	TFIIF complex (transcription factor IIF)	Human	None	None	P13984;P35269	2963;2962	MI:0027-cosedimentation	GO:0006352;GO:0000287;GO:0005524;GO:0005634	DNA-templated transcription initiation;magnesium ion binding;ATP binding;nucleus	11.02.03.01.01;16.17.07;16.19.03;70.10	transcription initiation;magnesium binding;ATP binding;nucleus	9836642	TFIIF facilitates activator-dependent transcription initiation on chromatin templates.	None	None	Homo sapiens (Human);Homo sapiens (Human)	General transcription factor IIF subunit 2;General transcription factor IIF subunit 1	GTF2F2;GTF2F1	RAP30;RAP74
155	TFIID complex	Human	None	None	O00268;P20226;P21675;P49848;Q12962;Q15542;Q15544;Q16594;Q6P1X5	6874;6908;6872;6878;6881;6877;6882;6880;6873	MI:0019-coimmunoprecipitation	GO:0006352;GO:2001141;GO:0006355;GO:0003677;GO:0005634	DNA-templated transcription initiation;regulation of RNA biosynthetic process;regulation of DNA-templated transcription;DNA binding;nucleus	11.02.03.01.01;11.02.03.04;16.03.01;70.10	transcription initiation;transcriptional control;DNA binding;nucleus	9836642	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transcription initiation factor TFIID subunit 4;TATA-box-binding protein;Transcription initiation factor TFIID subunit 1;Transcription initiation factor TFIID subunit 6;Transcription initiation factor TFIID subunit 10;Transcription initiation factor TFIID subunit 5;Transcription initiation factor TFIID subunit 11;Transcription initiation factor TFIID subunit 9;Transcription initiation factor TFIID subunit 2	TAF4;TBP;TAF1;TAF6;TAF10;TAF5;TAF11;TAF9;TAF2	TAF2C TAF2C1 TAF4A TAFII130 TAFII135;GTF2D1 TF2D TFIID;BA2R CCG1 CCGS TAF2A;TAF2E TAFII70;TAF2A TAF2H TAFII30;TAF2D;TAF2I;TAF2G TAFII31;CIF150 TAF2B
156	Retrotranslocation complex	Human	None	HeLa cells; HEK 293T cells	P57678;Q86TM6;Q9BUN8	50628;84447;79139	MI:0019-coimmunoprecipitation	GO:0015031;GO:0140318	protein transport;protein transporter activity	20.01.10	protein transport	16186510	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Gem-associated protein 4;E3 ubiquitin-protein ligase synoviolin;Derlin-1	GEMIN4;SYVN1;DERL1	None;HRD1 KIAA1810;DER1
159	Condensin I-PARP-1-XRCC1 complex	Human	None	HeLa cells	O95347;P09874;P18887;Q15003;Q15021;Q9BPX3;Q9NTJ3	10592;142;7515;23397;9918;64151;10051	MI:0006-anti bait coimmunoprecipitation	GO:0006281;GO:0006974;GO:0005634	DNA repair;cellular response to DNA damage stimulus;nucleus	10.01.05.01;32.01.09;70.10	DNA repair;DNA damage response;nucleus	16543152	The association between PARP-1 and XRCC1 was enhanced in response to DNA damage.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Structural maintenance of chromosomes protein 2;Poly [ADP-ribose] polymerase 1;DNA repair protein XRCC1;Condensin complex subunit 2;Condensin complex subunit 1;Condensin complex subunit 3;Structural maintenance of chromosomes protein 4	SMC2;PARP1;XRCC1;NCAPH;NCAPD2;NCAPG;SMC4	CAPE SMC2L1;ADPRT PPOL;None;BRRN BRRN1 CAPH KIAA0074;CAPD2 CNAP1 KIAA0159;CAPG NYMEL3;CAPC SMC4L1
160	Condensin II	Human	None	HeLa cells	O95347;P42695;Q6IBW4;Q86XI2;Q9NTJ3	10592;23310;29781;54892;10051	MI:0006-anti bait coimmunoprecipitation	GO:0000278;GO:0030261;GO:0051276;GO:0005634	mitotic cell cycle;chromosome condensation;chromosome organization;nucleus	10.03.01.01;10.03.04.03;42.10.03;70.10	mitotic cell cycle;chromosome condensation;organization of chromosome structure;nucleus	14532007	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Structural maintenance of chromosomes protein 2;Condensin-2 complex subunit D3;Condensin-2 complex subunit H2;Condensin-2 complex subunit G2;Structural maintenance of chromosomes protein 4	SMC2;NCAPD3;NCAPH2;NCAPG2;SMC4	CAPE SMC2L1;CAPD3 KIAA0056;CAPH2;LUZP5;CAPC SMC4L1
162	COG complex	Human	Conserved oligomeric Golgi (COG) complex	HeLa cells	P83436;Q14746;Q8WTW3;Q96JB2;Q96MW5;Q9H9E3;Q9UP83;Q9Y2V7	91949;22796;9382;83548;84342;25839;10466;57511	MI:0007-anti tag coimmunoprecipitation;MI:0040-electron microscopy;MI:0051-fluorescence technology	GO:0006486;GO:0007030;GO:0005794;GO:0017119;GO:0016192	protein glycosylation;Golgi organization;Golgi apparatus;Golgi transport complex;vesicle-mediated transport	14.07.02;42.08;70.08;20.09.07	modification with sugar residues (e.g. glycosylation, deglycosylation);Golgi;Golgi;vesicular transport (Golgi network, etc.)	11980916	The Golgi transport complex (GTC), identified in an in vitro membrane transport assay, (b) the ldlCp complex, identified in analyses of CHO cell mutants with defects in Golgi-associated glycosylation reactions, and (c) the mammalian Sec34 complex, identified by homology to yeast Sec34p, implicated in vesicular transport, are shown to be identical. They are renamed conserved oligomeric Golgi (COG) complex by the authors.	Deficiencies in COG1, COG7, COG8 cause a novel group of Cogenital Disorders of Glycosylation II (PMID:17904886).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Conserved oligomeric Golgi complex subunit 7;Conserved oligomeric Golgi complex subunit 2;Conserved oligomeric Golgi complex subunit 1;Conserved oligomeric Golgi complex subunit 3;Conserved oligomeric Golgi complex subunit 8;Conserved oligomeric Golgi complex subunit 4;Conserved oligomeric Golgi complex subunit 5;Conserved oligomeric Golgi complex subunit 6	COG7;COG2;COG1;COG3;COG8;COG4;COG5;COG6	None;LDLC;KIAA1381 LDLB;SEC34;None;None;GOLTC1 GTC90;KIAA1134
164	Cohesin-SA1 complex	Human	None	HeLa cells	O60216;Q14683;Q8WVM7;Q9UQE7	5885;8243;10274;9126	MI:0004-affinity chromatography technology;MI:0006-anti bait coimmunoprecipitation	GO:0000279;GO:0007059;GO:0003677;GO:0051276;GO:0005694;GO:0000278	M phase;chromosome segregation;DNA binding;chromosome organization;chromosome;mitotic cell cycle	10.03.01.01.11;10.03.04.05;16.03.01;42.10.03;70.10.03;10.03.01.01	M phase;chromosome segregation/division;DNA binding;organization of chromosome structure;chromosome;mitotic cell cycle	10931856	The cohesin complex binds directly to double-stranded DNA and induces the formation of large protein-DNA aggregates. (PMID: 11250156)	None	In HeLa cell extracts, the ratio between the hSA1-containing complex (h-cohesin SA1) and the hSA2-containing complex (h-cohesin SA2) is about 1:3. (PMID: 10931856)	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Double-strand-break repair protein rad21 homolog;Structural maintenance of chromosomes protein 1A;Cohesin subunit SA-1;Structural maintenance of chromosomes protein 3	RAD21;SMC1A;STAG1;SMC3	HR21 KIAA0078 NXP1 SCC1;DXS423E KIAA0178 SB1.8 SMC1 SMC1L1;SA1 SCC3;BAM BMH CSPG6 SMC3L1
166	Cohesin-SA2 complex	Human	None	HeLa cells	O60216;Q14683;Q8N3U4;Q9UQE7	5885;8243;10735;9126	MI:0004-affinity chromatography technology	GO:0000279;GO:0007059;GO:0003677;GO:0005694;GO:0000278	M phase;chromosome segregation;DNA binding;chromosome;mitotic cell cycle	10.03.01.01.11;10.03.04.05;16.03.01;70.10.03;10.03.01.01	M phase;chromosome segregation/division;DNA binding;chromosome;mitotic cell cycle	11250156	The cohesin complex binds directly to double-stranded DNA and induces the formation of large protein-DNA aggregates.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Double-strand-break repair protein rad21 homolog;Structural maintenance of chromosomes protein 1A;Cohesin subunit SA-2;Structural maintenance of chromosomes protein 3	RAD21;SMC1A;STAG2;SMC3	HR21 KIAA0078 NXP1 SCC1;DXS423E KIAA0178 SB1.8 SMC1 SMC1L1;SA2;BAM BMH CSPG6 SMC3L1
168	Protein-sorting ternary complex (EPS15, HGS, STAM2)	Human	None	HEp-2  cells	O14964;O75886;P42566	9146;10254;2060	MI:0019-coimmunoprecipitation;MI:0047-far western blotting	GO:0006886;GO:0006605;GO:0015031	intracellular protein transport;protein targeting;protein transport	14.04;20.01.10	protein targeting, sorting and translocation;protein transport	12551915	Hrs, Eps15, and STAM proteins function in a multivalent complex that sorts ubiquitinated proteins into the multivesicular body pathway.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Hepatocyte growth factor-regulated tyrosine kinase substrate;Signal transducing adapter molecule 2;Epidermal growth factor receptor substrate 15	HGS;STAM2;EPS15	HRS;HBP;AF1P
169	Protein-sorting ternary complex (EPS15, HGS, STAM1)	Human	None	HEp-2  cells	O14964;P42566;Q92783	9146;2060;8027	MI:0019-coimmunoprecipitation;MI:0047-far western blotting	GO:0006886;GO:0006605;GO:0015031	intracellular protein transport;protein targeting;protein transport	14.04;20.01.10	protein targeting, sorting and translocation;protein transport	12551915	Hrs, Eps15, and STAM proteins function in a multivalent complex that sorts ubiquitinated proteins into the multivesicular body pathway.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Hepatocyte growth factor-regulated tyrosine kinase substrate;Epidermal growth factor receptor substrate 15;Signal transducing adapter molecule 1	HGS;EPS15;STAM	HRS;AF1P;STAM1
173	MRN complex	Human	RAD50-MRE11-p95 complex; MRE11A-NBN-RAD50 complex; MRE11-RAD50-NBN complex; MRE11A-NBN-RAD50 complex	Raji cells	O60934;P49959;Q92878	4683;4361;10111	MI:0004-affinity chromatography technology	GO:0006308;GO:0006281;GO:0000075;GO:0003677;GO:0006974;GO:0005634;GO:0004519;GO:0004527	DNA catabolic process;DNA repair;cell cycle checkpoint signaling;DNA binding;cellular response to DNA damage stimulus;nucleus;endonuclease activity;exonuclease activity	01.03.16.03;10.01.05.01;10.03.01.03;16.03.01;32.01.09;70.10	DNA degradation;DNA repair;cell cycle checkpoints (checkpoints of morphogenesis, DNA-damage,-replication, mitotic phase and spindle);DNA binding;DNA damage response;nucleus	9705271	The MRN complex possesses manganese-dependent single-stranded DNA endonuclease and 3' to 5' exonuclease activities, important for recombination, repair, and genomic stability.	Rad50-MRE11-p95 protein complex is involved in Nijmegen breakage syndrome. (PMID: 10612394)	Purification of this complex has been also described in PMID: 10612394, 10346816, 12917393, 16163361, 9590181 and 15039997.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Nibrin;Double-strand break repair protein MRE11;DNA repair protein RAD50	NBN;MRE11;RAD50	NBS NBS1 P95;HNGS1 MRE11A;None
178	Respiratory chain complex I (holoenzyme), mitochondrial	Human	NADH:ubiquinone oxidoreductase (EC 1.6.5.3)	heart	O00217;O00483;O14561;O15239;O43181;O43674;O43676;O43677;O43678;O43920;O75251;O75306;O75380;O75438;O75489;O95139;O95167;O95168;O95169;O95178;O95182;O95298;O95299;O96000;P03886;P03891;P03897;P03901;P03915;P03923;P17568;P19404;P28331;P49821;P51970;P56181;P56556;Q16718;Q16795;Q86Y39;Q9NX14;Q9P0J0;Q9UI09;Q9Y6M9	4728;4697;4706;4694;4724;4711;4709;4717;4695;4725;374291;4720;4726;4707;4722;4712;4696;4710;4714;4708;4701;4718;4705;4716;4535;4536;4537;4539;4540;4541;4713;4729;4719;4723;4702;4731;4700;4698;4704;126328;54539;51079;55967;4715	MI:0006-anti bait coimmunoprecipitation	GO:0022904;GO:0005743;GO:0006119;GO:0009060;GO:1902600	respiratory electron transport chain;mitochondrial inner membrane;oxidative phosphorylation;aerobic respiration;proton transmembrane transport	02.11.07;20.01.15;70.16.05;02.13.03	regulation of electron transport and membrane-associated energy conservation;electron transport;mitochondrial inner membrane;aerobic respiration	12611891	Complex I is the first multiprotein complex of the OXPHOS system and participates in the formation of a proton gradient across the inner mitochondrial membrane coupled to transfer of electrons from NADH to ubiquinone.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial;Cytochrome c oxidase subunit NDUFA4;Acyl carrier protein, mitochondrial;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1;NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3;NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2;NADH dehydrogenase [ubiquinone] iron-sulfur protein 5;NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial;NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial;NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1;NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7;NADH dehydrogenase [ubiquinone] 1 subunit C2;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10;NADH-ubiquinone oxidoreductase chain 1;NADH-ubiquinone oxidoreductase chain 2;NADH-ubiquinone oxidoreductase chain 3;NADH-ubiquinone oxidoreductase chain 4L;NADH-ubiquinone oxidoreductase chain 5;NADH-ubiquinone oxidoreductase chain 6;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7;NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial;NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial;NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8;NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9	NDUFS8;NDUFA4;NDUFAB1;NDUFA1;NDUFS4;NDUFB5;NDUFB3;NDUFC1;NDUFA2;NDUFS5;NDUFS7;NDUFS2;NDUFS6;NDUFB1;NDUFS3;NDUFB6;NDUFA3;NDUFB4;NDUFB8;NDUFB2;NDUFA7;NDUFC2;NDUFA10;NDUFB10;MT-ND1;MT-ND2;MT-ND3;MT-ND4L;MT-ND5;MT-ND6;NDUFB7;NDUFV2;NDUFS1;NDUFV1;NDUFA8;NDUFV3;NDUFA6;NDUFA5;NDUFA9;NDUFA11;NDUFB11;NDUFA13;NDUFA12;NDUFB9	None;None;None;None;None;None;None;None;None;None;None;None;None;None;None;None;None;None;None;None;None;None;None;None;MTND1 NADH1 ND1;MTND2 NADH2 ND2;MTND3 NADH3 ND3;MTND4L NADH4L ND4L;MTND5 NADH5 ND5;MTND6 NADH6 ND6;None;None;None;UQOR1;None;None;LYRM6 NADHB14;None;NDUFS2L;None;None;GRIM19;DAP13;LYRM3 UQOR22
180	PNUTS-PPP1CA complex	Human	PNUTS-PP1 complex	HEK293T cells	P62136;Q96QC0	5499;5514	MI:0007-anti tag coimmunoprecipitation	GO:0004857	enzyme inhibitor activity	18.02.01.02	enzyme inhibitor	12574161	PNUTS exhibits a discrete nuclear compartmentalization and is found in a stable complex with PP1 in mammalian cell lysates.	None	A 50-amino acid domain in the center of PNUTS mediated both high affinity PP1 binding and inhibition of PP1 activity.	Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein phosphatase PP1-alpha catalytic subunit;Serine/threonine-protein phosphatase 1 regulatory subunit 10	PPP1CA;PPP1R10	PPP1A;CAT53 FB19 PNUTS
181	26S proteasome	Human	None	None	O14818;P17980;P20618;P25786;P25787;P25788;P25789;P28066;P28070;P28072;P28074;P35998;P43686;P49720;P49721;P55036;P60900;P62191;P62195;P62333;Q99436;Q9UNM6	5688;5702;5689;5682;5683;5684;5685;5686;5692;5694;5693;5701;5704;5691;5690;5710;5687;5700;5705;5706;5695;5719	MI:0019-coimmunoprecipitation	GO:0043161;GO:0006511;GO:0005515;GO:0006950;GO:0005737;GO:0005634	proteasome-mediated ubiquitin-dependent protein catabolic process;ubiquitin-dependent protein catabolic process;protein binding;response to stress;cytoplasm;nucleus	14.13.01.01;16.01;32.01;70.03;70.10	proteasomal degradation (ubiquitin/proteasomal pathway);protein binding;stress response;cytoplasm;nucleus	11812135	The proteasome is an essential component of the ATP-dependent proteolytic pathway in eukaryotic cells and is responsible for the degradation of most cellular proteins (for reviews see PMID:8811196 and PMID:10872471). It contains a barrel-shaped proteolytic core complex (the 20S proteasome), and is capped at one or both ends by regulatory complexes like the 19S complex (PMID:11812135), modulator (PMID:8621709), PA28 (PMID:9325261) and PA28gamma (PMID:9325261). Interferon-gamma (IFN-gamma) alters the peptide-degrading specificity of proteasomes and produces an immunoproteasome responsible for accelerated processing of nonself endogenous antigens by inducing the replacement of subunits Psmb5, Psmb6 and Psmb7 by Psmb8, Psmb9 and Psmb10, respectively.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Proteasome subunit alpha type-7;26S proteasome regulatory subunit 6A;Proteasome subunit beta type-1;Proteasome subunit alpha type-1;Proteasome subunit alpha type-2;Proteasome subunit alpha type-3;Proteasome subunit alpha type-4;Proteasome subunit alpha type-5;Proteasome subunit beta type-4;Proteasome subunit beta type-6;Proteasome subunit beta type-5;26S proteasome regulatory subunit 7;26S proteasome regulatory subunit 6B;Proteasome subunit beta type-3;Proteasome subunit beta type-2;26S proteasome non-ATPase regulatory subunit 4;Proteasome subunit alpha type-6;26S proteasome regulatory subunit 4;26S proteasome regulatory subunit 8;26S proteasome regulatory subunit 10B;Proteasome subunit beta type-7;26S proteasome non-ATPase regulatory subunit 13	PSMA7;PSMC3;PSMB1;PSMA1;PSMA2;PSMA3;PSMA4;PSMA5;PSMB4;PSMB6;PSMB5;PSMC2;PSMC4;PSMB3;PSMB2;PSMD4;PSMA6;PSMC1;PSMC5;PSMC6;PSMB7;PSMD13	HSPC;TBP1;PSC5;HC2 NU PROS30 PSC2;HC3 PSC3;HC8 PSC8;HC9 PSC9;None;PROS26;LMPY Y;LMPX MB1 X;MSS1;MIP224 TBP7;None;None;MCB1;PROS27;None;SUG1;SUG2;Z;None
186	Wave-2 complex	Human	WAVE complex; WAVE regulatory complex (WRC)	None	Q7L576;Q8IZP0;Q8WUW1;Q9Y2A7;Q9Y6W5	23191;10006;55845;10787;10163	MI:0029-cosedimentation through density gradient;MI:0091-chromatography technology	GO:0007264;GO:0016477;GO:0030036;GO:0015629	small GTPase mediated signal transduction;cell migration;actin cytoskeleton organization;actin cytoskeleton	30.01.05.05.01;34.05.01;42.04.03;70.04.03	small GTPase mediated signal transduction;cell migration;actin cytoskeleton;actin cytoskeleton	15070726	Proteins are only present in the complexed form, with the exception of Hspc (C3orf10). The complex is organized around a core of Nap and Abi. Sra is a peripheral subunit recruited on the Nap side, whereas the Wave and Hspc subunits are recruited on the Abi side of the core.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cytoplasmic FMR1-interacting protein 1;Abl interactor 1;Protein BRICK1;Nck-associated protein 1;Actin-binding protein WASF2	CYFIP1;ABI1;BRK1;NCKAP1;WASF2	KIAA0068;SSH3BP1;C3orf10;HEM2 KIAA0587 NAP1;WAVE2
189	BAF complex	Human	SWI/SNF complex A	KB cells	O14497;O94805;O96019;P51531;P51532;P60709;P63261;Q12824;Q8NFD5;Q8TAQ2;Q92922;Q969G3;Q96GM5	8289;51412;86;6595;6597;60;71;6598;57492;6601;6599;6605;6602	MI:0004-affinity chromatography technology;MI:0019-coimmunoprecipitation	GO:0006265;GO:0045893;GO:0003677;GO:0051276;GO:0005634	DNA topological change;positive regulation of DNA-templated transcription;DNA binding;chromosome organization;nucleus	10.01.09.05;11.02.03.04.01;16.03.01;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription activation;DNA binding;organization of chromosome structure;nucleus	11078522	None	None	Since the authors did not specify Actin as well as Actin-like protein 6 and ARID1, we used isoform ACTB, isoform ACTL6A or isoform ARID1A, respectively. At the time of annotation, the additional member BAF110 of the protein complex was not found in the UniProt database.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	AT-rich interactive domain-containing protein 1A;Actin-like protein 6B;Actin-like protein 6A;Probable global transcription activator SNF2L2;Transcription activator BRG1;Actin, cytoplasmic 1;Actin, cytoplasmic 2;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1;AT-rich interactive domain-containing protein 1B;SWI/SNF complex subunit SMARCC2;SWI/SNF complex subunit SMARCC1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1	ARID1A;ACTL6B;ACTL6A;SMARCA2;SMARCA4;ACTB;ACTG1;SMARCB1;ARID1B;SMARCC2;SMARCC1;SMARCE1;SMARCD1	BAF250 BAF250A C1orf4 OSA1 SMARCF1;ACTL6 BAF53B;BAF53 BAF53A INO80K;BAF190B BRM SNF2A SNF2L2;BAF190A BRG1 SNF2B SNF2L4;None;ACTG;BAF47, INI1, SNF5L1;BAF250B DAN15 KIAA1235 OSA2;BAF170;BAF155;BAF57;BAF60A
190	Mitotic checkpoint complex	Human	APC/C inhibitory factor; MCC complex	None	O43684;O60566;Q12834;Q13257	9184;701;991;4085	MI:0006-anti bait coimmunoprecipitation;MI:0071-molecular sieving;MI:0096-pull down	GO:0000075	cell cycle checkpoint signaling	10.03.01.03	cell cycle checkpoints (checkpoints of morphogenesis, DNA-damage,-replication, mitotic phase and spindle)	11535616	MCC inhibitory activity is 3,000-fold greater than that of recombinant MAD2,MCC is not generated from kinetochores, as it is also present and active in interphase cells.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mitotic checkpoint protein BUB3;Mitotic checkpoint serine/threonine-protein kinase BUB1 beta;Cell division cycle protein 20 homolog;Mitotic spindle assembly checkpoint protein MAD2A	BUB3;BUB1B;CDC20;MAD2L1	None;BUBR1 MAD3L SSK1;None;MAD2
192	PA28-20S proteasome	Human	None	None	O14818;P20618;P25786;P25787;P25788;P25789;P28066;P28070;P28072;P28074;P49720;P49721;P60900;Q06323;Q99436;Q9UL46	5688;5689;5682;5683;5684;5685;5686;5692;5694;5693;5691;5690;5687;5720;5695;5721	MI:0029-cosedimentation through density gradient	GO:0016485;GO:0043161;GO:0006511;GO:0006950;GO:0005737;GO:0005634	protein processing;proteasome-mediated ubiquitin-dependent protein catabolic process;ubiquitin-dependent protein catabolic process;response to stress;cytoplasm;nucleus	14.07.11;14.13.01.01;32.01;70.03;70.10	protein processing (proteolytic);proteasomal degradation (ubiquitin/proteasomal pathway);stress response;cytoplasm;nucleus	11676531	The proteasome is an essential component of the ATP-dependent proteolytic pathway in eukaryotic cells and is responsible for the degradation of most cellular proteins (for reviews see PMID:8811196 and PMID:10872471). It contains a barrel-shaped proteolytic core complex (the 20S proteasome), and is capped at one or both ends by regulatory complexes like the 19S complex (PMID:11812135), modulator (PMID:8621709), PA28 (PMID:9325261) and PA28gamma (PMID:9325261). Interferon-gamma (IFN-gamma) alters the peptide-degrading specificity of proteasomes and produces an immunoproteasome responsible for accelerated processing of nonself endogenous antigens by inducing the replacement of subunits Psmb5, Psmb6 and Psmb7 by Psmb8, Psmb9 and Psmb10, respectively.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Proteasome subunit alpha type-7;Proteasome subunit beta type-1;Proteasome subunit alpha type-1;Proteasome subunit alpha type-2;Proteasome subunit alpha type-3;Proteasome subunit alpha type-4;Proteasome subunit alpha type-5;Proteasome subunit beta type-4;Proteasome subunit beta type-6;Proteasome subunit beta type-5;Proteasome subunit beta type-3;Proteasome subunit beta type-2;Proteasome subunit alpha type-6;Proteasome activator complex subunit 1;Proteasome subunit beta type-7;Proteasome activator complex subunit 2	PSMA7;PSMB1;PSMA1;PSMA2;PSMA3;PSMA4;PSMA5;PSMB4;PSMB6;PSMB5;PSMB3;PSMB2;PSMA6;PSME1;PSMB7;PSME2	HSPC;PSC5;HC2 NU PROS30 PSC2;HC3 PSC3;HC8 PSC8;HC9 PSC9;None;PROS26;LMPY Y;LMPX MB1 X;None;None;PROS27;IFI5111;Z;None
193	PA700-20S-PA28 complex	Human	proteasome	None	O00231;O00232;O00233;O00487;O14818;O43242;O75832;P17980;P20618;P25786;P25787;P25788;P25789;P28066;P28070;P28072;P28074;P35998;P43686;P48556;P49720;P49721;P51665;P55036;P60900;P62191;P62195;P62333;Q06323;Q13200;Q15008;Q16401;Q99436;Q99460;Q9UL46;Q9UNM6	5717;5718;5715;10213;5688;5709;5716;5702;5689;5682;5683;5684;5685;5686;5692;5694;5693;5701;5704;5714;5691;5690;5713;5710;5687;5700;5705;5706;5720;5708;9861;5711;5695;5707;5721;5719	MI:0029-cosedimentation through density gradient	GO:0043161;GO:0005515;GO:0016504	proteasome-mediated ubiquitin-dependent protein catabolic process;protein binding;peptidase activator activity	14.13.01.01;16.01;18.02.01.01.03	proteasomal degradation (ubiquitin/proteasomal pathway);protein binding;protease activator	11676531	The proteasome is an essential component of the ATP-dependent proteolytic pathway in eukaryotic cells and is responsible for the degradation of most cellular proteins (for reviews see PMID:8811196 and PMID:10872471). It contains a barrel-shaped proteolytic core complex (the 20S proteasome), and is capped at one or both ends by regulatory complexes like the 19S complex (PMID:11812135), modulator (PMID:8621709), PA28 (PMID:9325261) and PA28gamma (PMID:9325261). Interferon-gamma (IFN-gamma) alters the peptide-degrading specificity of proteasomes and produces an immunoproteasome responsible for accelerated processing of nonself endogenous antigens by inducing the replacement of subunits Psmb5, Psmb6 and Psmb7 by Psmb8, Psmb9 and Psmb10, respectively.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	26S proteasome non-ATPase regulatory subunit 11;26S proteasome non-ATPase regulatory subunit 12;26S proteasome non-ATPase regulatory subunit 9;26S proteasome non-ATPase regulatory subunit 14;Proteasome subunit alpha type-7;26S proteasome non-ATPase regulatory subunit 3;26S proteasome non-ATPase regulatory subunit 10;26S proteasome regulatory subunit 6A;Proteasome subunit beta type-1;Proteasome subunit alpha type-1;Proteasome subunit alpha type-2;Proteasome subunit alpha type-3;Proteasome subunit alpha type-4;Proteasome subunit alpha type-5;Proteasome subunit beta type-4;Proteasome subunit beta type-6;Proteasome subunit beta type-5;26S proteasome regulatory subunit 7;26S proteasome regulatory subunit 6B;26S proteasome non-ATPase regulatory subunit 8;Proteasome subunit beta type-3;Proteasome subunit beta type-2;26S proteasome non-ATPase regulatory subunit 7;26S proteasome non-ATPase regulatory subunit 4;Proteasome subunit alpha type-6;26S proteasome regulatory subunit 4;26S proteasome regulatory subunit 8;26S proteasome regulatory subunit 10B;Proteasome activator complex subunit 1;26S proteasome non-ATPase regulatory subunit 2;26S proteasome non-ATPase regulatory subunit 6;26S proteasome non-ATPase regulatory subunit 5;Proteasome subunit beta type-7;26S proteasome non-ATPase regulatory subunit 1;Proteasome activator complex subunit 2;26S proteasome non-ATPase regulatory subunit 13	PSMD11;PSMD12;PSMD9;PSMD14;PSMA7;PSMD3;PSMD10;PSMC3;PSMB1;PSMA1;PSMA2;PSMA3;PSMA4;PSMA5;PSMB4;PSMB6;PSMB5;PSMC2;PSMC4;PSMD8;PSMB3;PSMB2;PSMD7;PSMD4;PSMA6;PSMC1;PSMC5;PSMC6;PSME1;PSMD2;PSMD6;PSMD5;PSMB7;PSMD1;PSME2;PSMD13	None;None;None;POH1;HSPC;None;None;TBP1;PSC5;HC2 NU PROS30 PSC2;HC3 PSC3;HC8 PSC8;HC9 PSC9;None;PROS26;LMPY Y;LMPX MB1 X;MSS1;MIP224 TBP7;None;None;None;MOV34L;MCB1;PROS27;None;SUG1;SUG2;IFI5111;TRAP2;KIAA0107 PFAAP4;KIAA0072;Z;None;None;None
194	PA28gamma-20S proteasome	Human	None	Placenta	O14818;P20618;P25786;P25787;P25788;P25789;P28066;P28070;P28072;P28074;P49720;P49721;P60900;P61289;Q99436	5688;5689;5682;5683;5684;5685;5686;5692;5694;5693;5691;5690;5687;10197;5695	MI:0029-cosedimentation through density gradient	GO:0016485;GO:0043161;GO:0006511;GO:0006950;GO:0005737;GO:0005634	protein processing;proteasome-mediated ubiquitin-dependent protein catabolic process;ubiquitin-dependent protein catabolic process;response to stress;cytoplasm;nucleus	14.07.11;14.13.01.01;32.01;70.03;70.10	protein processing (proteolytic);proteasomal degradation (ubiquitin/proteasomal pathway);stress response;cytoplasm;nucleus	7811265	The proteasome is an essential component of the ATP-dependent proteolytic pathway in eukaryotic cells and is responsible for the degradation of most cellular proteins (for reviews see PMID:8811196 and PMID:10872471). It contains a barrel-shaped proteolytic core complex (the 20S proteasome), and is capped at one or both ends by regulatory complexes like the 19S complex (PMID:11812135), modulator (PMID:8621709), PA28 (PMID:9325261) and PA28gamma (PMID:9325261). Interferon-gamma (IFN-gamma) alters the peptide-degrading specificity of proteasomes and produces an immunoproteasome responsible for accelerated processing of nonself endogenous antigens by inducing the replacement of subunits Psmb5, Psmb6 and Psmb7 by Psmb8, Psmb9 and Psmb10, respectively.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Proteasome subunit alpha type-7;Proteasome subunit beta type-1;Proteasome subunit alpha type-1;Proteasome subunit alpha type-2;Proteasome subunit alpha type-3;Proteasome subunit alpha type-4;Proteasome subunit alpha type-5;Proteasome subunit beta type-4;Proteasome subunit beta type-6;Proteasome subunit beta type-5;Proteasome subunit beta type-3;Proteasome subunit beta type-2;Proteasome subunit alpha type-6;Proteasome activator complex subunit 3;Proteasome subunit beta type-7	PSMA7;PSMB1;PSMA1;PSMA2;PSMA3;PSMA4;PSMA5;PSMB4;PSMB6;PSMB5;PSMB3;PSMB2;PSMA6;PSME3;PSMB7	HSPC;PSC5;HC2 NU PROS30 PSC2;HC3 PSC3;HC8 PSC8;HC9 PSC9;None;PROS26;LMPY Y;LMPX MB1 X;None;None;PROS27;None;Z
201	HUIC complex	Human	BRCA1-BARD1 complex	None	P38398;Q99728	672;580	MI:0029-cosedimentation through density gradient;MI:0226-ion exchange chromatography	GO:0000075;GO:0005634;GO:0051726	cell cycle checkpoint signaling;nucleus;regulation of cell cycle	10.03.01.03;70.10;10.03.01	cell cycle checkpoints (checkpoints of morphogenesis, DNA-damage,-replication, mitotic phase and spindle);nucleus;mitotic cell cycle and cell cycle control	11504724	The HUIC complex has been isolated after treating cells with hydroxyurea.	BRCA1 is involved in breast cancer.	None	Homo sapiens (Human);Homo sapiens (Human)	Breast cancer type 1 susceptibility protein;BRCA1-associated RING domain protein 1	BRCA1;BARD1	RNF53;None
205	Ubiquitin E3 ligase (VHL, TCEB1, TCEB2, CUL2, RBX1)	Human	VHL-Elongin BC-CUL2-RBX1 complex	None	P40337;P62877;Q13617;Q15369;Q15370	7428;9978;8453;6921;6923	MI:0028-cosedimentation in solution	GO:0016567;GO:0005515;GO:0006511	protein ubiquitination;protein binding;ubiquitin-dependent protein catabolic process	14.07.05;16.01;14.13.01.01	modification by ubiquitination, deubiquitination;protein binding;proteasomal degradation (ubiquitin/proteasomal pathway)	10535940	Ubiquitin E3 ligases covalently attach ubiquitin to a lysine residue on a target protein. Polyubiquitination marks proteins for degradation by the proteasome.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	von Hippel-Lindau disease tumor suppressor;E3 ubiquitin-protein ligase RBX1;Cullin-2;Elongin-C;Elongin-B	VHL;RBX1;CUL2;ELOC;ELOB	None;RNF75 ROC1;None;TCEB1;TCEB2
207	Ubiquitin E3 ligase (ASB2, TCEB1, TCEB2, CUL5, RNF7)	Human	Asb2-Elongin BC-Cul5-Rbx2 complex	None	Q15369;Q15370;Q93034;Q96Q27;Q9UBF6	6921;6923;8065;51676;9616	MI:0028-cosedimentation in solution	GO:0016567;GO:0005515;GO:0006511	protein ubiquitination;protein binding;ubiquitin-dependent protein catabolic process	14.07.05;16.01;14.13.01.01	modification by ubiquitination, deubiquitination;protein binding;proteasomal degradation (ubiquitin/proteasomal pathway)	16325183	Ubiquitin E3 ligases covalently attach ubiquitin to a lysine residue on a target protein. Polyubiquitination marks proteins for degradation by the proteasome.	None	The presence of Elongin BC was predicted by the authors but has not been shown experimentally.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Elongin-C;Elongin-B;Cullin-5;Ankyrin repeat and SOCS box protein 2;RING-box protein 2	ELOC;ELOB;CUL5;ASB2;RNF7	TCEB1;TCEB2;VACM1;None;RBX2 ROC2 SAG
208	Ubiquitin E3 ligase (ASB1, TCEB1, TCEB2, CUL5, RNF7)	Human	Asb1-Elongin BC-Cul5-Rbx2 complex	None	Q15369;Q15370;Q93034;Q9UBF6;Q9Y576	6921;6923;8065;9616;51665	MI:0028-cosedimentation in solution	GO:0016567;GO:0005515;GO:0006511	protein ubiquitination;protein binding;ubiquitin-dependent protein catabolic process	14.07.05;16.01;14.13.01.01	modification by ubiquitination, deubiquitination;protein binding;proteasomal degradation (ubiquitin/proteasomal pathway)	16325183	Ubiquitin E3 ligases covalently attach ubiquitin to a lysine residue on a target protein. Polyubiquitination marks proteins for degradation by the proteasome.	None	The presence of Elongin BC was predicted by the authors but has not been shown experimentally.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Elongin-C;Elongin-B;Cullin-5;RING-box protein 2;Ankyrin repeat and SOCS box protein 1	ELOC;ELOB;CUL5;RNF7;ASB1	TCEB1;TCEB2;VACM1;RBX2 ROC2 SAG;KIAA1146
209	Ubiquitin E3 ligase (ASB6, TCEB1, TCEB2, CUL5, RNF7)	Human	Asb6-Elongin BC-Cul5-Rbx2 complex	None	Q15369;Q15370;Q93034;Q9NWX5;Q9UBF6	6921;6923;8065;140459;9616	MI:0028-cosedimentation in solution	GO:0016567;GO:0005515;GO:0006511	protein ubiquitination;protein binding;ubiquitin-dependent protein catabolic process	14.07.05;16.01;14.13.01.01	modification by ubiquitination, deubiquitination;protein binding;proteasomal degradation (ubiquitin/proteasomal pathway)	16325183	Ubiquitin E3 ligases covalently attach ubiquitin to a lysine residue on a target protein. Polyubiquitination marks proteins for degradation by the proteasome.	None	The presence of Elongin BC was predicted by the authors but has not been shown experimentally.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Elongin-C;Elongin-B;Cullin-5;Ankyrin repeat and SOCS box protein 6;RING-box protein 2	ELOC;ELOB;CUL5;ASB6;RNF7	TCEB1;TCEB2;VACM1;None;RBX2 ROC2 SAG
210	Ubiquitin E3 ligase (ASB7, TCEB1, TCEB2, CUL5, RNF7)	Human	Asb7-Elongin BC-Cul5-Rbx2 complex	None	Q15369;Q15370;Q93034;Q9H672;Q9UBF6	6921;6923;8065;140460;9616	MI:0028-cosedimentation in solution	GO:0016567;GO:0005515;GO:0006511	protein ubiquitination;protein binding;ubiquitin-dependent protein catabolic process	14.07.05;16.01;14.13.01.01	modification by ubiquitination, deubiquitination;protein binding;proteasomal degradation (ubiquitin/proteasomal pathway)	16325183	Ubiquitin E3 ligases covalently attach ubiquitin to a lysine residue on a target protein. Polyubiquitination marks proteins for degradation by the proteasome.	None	The presence of Elongin BC was predicted by the authors but has not been shown experimentally.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Elongin-C;Elongin-B;Cullin-5;Ankyrin repeat and SOCS box protein 7;RING-box protein 2	ELOC;ELOB;CUL5;ASB7;RNF7	TCEB1;TCEB2;VACM1;None;RBX2 ROC2 SAG
211	Ubiquitin E3 ligase (ASB12, TCEB1, TCEB2, CUL5, RNF7)	Human	Asb12-Elongin BC-Cul5-Rbx2 complex	None	Q15369;Q15370;Q8WXK4;Q93034;Q9UBF6	6921;6923;142689;8065;9616	MI:0028-cosedimentation in solution	GO:0016567;GO:0005515;GO:0006511	protein ubiquitination;protein binding;ubiquitin-dependent protein catabolic process	14.07.05;16.01;14.13.01.01	modification by ubiquitination, deubiquitination;protein binding;proteasomal degradation (ubiquitin/proteasomal pathway)	16325183	Ubiquitin E3 ligases covalently attach ubiquitin to a lysine residue on a target protein. Polyubiquitination marks proteins for degradation by the proteasome.	None	The presence of Elongin BC was predicted by the authors but has not been shown experimentally.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Elongin-C;Elongin-B;Ankyrin repeat and SOCS box protein 12;Cullin-5;RING-box protein 2	ELOC;ELOB;ASB12;CUL5;RNF7	TCEB1;TCEB2;None;VACM1;RBX2 ROC2 SAG
213	DNA ligase IV-XRCC1 complex	Human	None	HeLa cells	P18887;P49917	7515;3981	MI:0004-affinity chromatography technology	GO:0006281;GO:0005634	DNA repair;nucleus	10.01.05.01;70.10	DNA repair;nucleus	7760816	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	DNA repair protein XRCC1;DNA ligase 4	XRCC1;LIG4	None;None
214	Ubiquitin E3 ligase (WSB1, TCEB1, TCEB2, CUL5, RBX1)	Human	WSB1-Elongin BC-CUL5-RBX1 complex	HEK-293 cells	P62877;Q15369;Q15370;Q93034;Q9Y6I7	9978;6921;6923;8065;26118	MI:0019-coimmunoprecipitation	GO:0016567;GO:0043161;GO:0006511;GO:0005515;GO:0007224;GO:0005783	protein ubiquitination;proteasome-mediated ubiquitin-dependent protein catabolic process;ubiquitin-dependent protein catabolic process;protein binding;smoothened signaling pathway;endoplasmic reticulum	14.07.05;14.13.01.01;16.01;30.05.02.16;70.07	modification by ubiquitination, deubiquitination;proteasomal degradation (ubiquitin/proteasomal pathway);protein binding;hedgehog-dependent signalling pathway;endoplasmic reticulum	15965468	Ubiquitin E3 ligases covalently attach ubiquitin to a lysine residue on a target protein. Polyubiquitination marks proteins for degradation by the proteasome. WSB-1 is a Hedgehog-inducible ubiquitin ligase that modulates thyroid hormone activation and PTHrP secretion in the developing growth plate.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase RBX1;Elongin-C;Elongin-B;Cullin-5;WD repeat and SOCS box-containing protein 1	RBX1;ELOC;ELOB;CUL5;WSB1	RNF75 ROC1;TCEB1;TCEB2;VACM1;SWIP1
218	CRSP complex	Human	cofactor required for Sp1	None	O43513;O60244;O75448;O95402;Q15648;Q6P2C8;Q9NVC6;Q9ULK4	9443;9282;9862;9441;5469;9442;9440;9439	MI:0029-cosedimentation through density gradient;MI:0226-ion exchange chromatography	GO:0045893;GO:0005515;GO:0005634	positive regulation of DNA-templated transcription;protein binding;nucleus	11.02.03.04.01;16.01;70.10	transcription activation;protein binding;nucleus	9989412	Several identical subunits appear in protein complexes like DRIP/ARC, CRSP, NAT, PC2, SMCC and Mediator, indicating that unique classes of transcription activators may share common sets or subsets of cofactors.	None	At the time of annotation, the additional 85kD component CRSP5 of the protein complex was not found in the UniProt database.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mediator of RNA polymerase II transcription subunit 7;Mediator of RNA polymerase II transcription subunit 14;Mediator of RNA polymerase II transcription subunit 24;Mediator of RNA polymerase II transcription subunit 26;Mediator of RNA polymerase II transcription subunit 1;Mediator of RNA polymerase II transcription subunit 27;Mediator of RNA polymerase II transcription subunit 17;Mediator of RNA polymerase II transcription subunit 23	MED7;MED14;MED24;MED26;MED1;MED27;MED17;MED23	ARC34 CRSP9;ARC150 CRSP2 CXorf4 DRIP150 EXLM1 RGR1 TRAP170;ARC100 CRSP4 DRIP100 KIAA0130 THRAP4 TRAP100;ARC70 CRSP7;ARC205 CRSP1 CRSP200 DRIP205 DRIP230 PBP PPARBP PPARGBP RB18A TRAP220 TRIP2;CRSP34 CRSP8;ARC77 CRSP6 DRIP77 DRIP80 TRAP80;ARC130 CRSP3 DRIP130 KIAA1216 SUR2
219	CAND1-CUL1-RBX1 complex	Human	None	None	P62877;Q13616;Q86VP6	9978;8454;55832	MI:0007-anti tag coimmunoprecipitation	GO:0005515;GO:0010265;GO:0051444	protein binding;SCF complex assembly;negative regulation of ubiquitin-protein transferase activity	16.01	protein binding	15537541	Cand1 forms a tight complex with the Cul1-Roc1 SCF catalytic core, inhibiting the assembly of the multisubunit E3 protein-ubiquitin ligase complex.The crystal structure of the Cand1-Cul1-Roc1 ternary complex reveals the detailed mechanisms of how Cand1 participates in regulating the assembly and disassembly of the SCF ubiquitin ligase complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase RBX1;Cullin-1;Cullin-associated NEDD8-dissociated protein 1	RBX1;CUL1;CAND1	RNF75 ROC1;None;KIAA0829 TIP120 TIP120A
220	ARF-Mule complex	Human	ARF-BP1-ARF-NPM1 complex	None	P06748;Q7Z6Z7;Q8N726	4869;10075;1029	MI:0007-anti tag coimmunoprecipitation	GO:0005515;GO:0005634	protein binding;nucleus	16.01;70.10	protein binding;nucleus	15989956	ARF is an inhibitor of the ARF-BP1 protein-ubiquitin ligase.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Nucleophosmin;E3 ubiquitin-protein ligase HUWE1;Tumor suppressor ARF	NPM1;HUWE1;CDKN2A	NPM;KIAA0312 KIAA1578 UREB1;CDKN2 MLM
221	CAND1-CUL2-RBX1 complex	Human	None	None	P62877;Q13617;Q86VP6	9978;8453;55832	MI:0007-anti tag coimmunoprecipitation	GO:0010265;GO:0051444	SCF complex assembly;negative regulation of ubiquitin-protein transferase activity	None	None	12609982	Binding of Cand1 to cullins inhibits the formation of E3 protein-ubiquitin ligases.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase RBX1;Cullin-2;Cullin-associated NEDD8-dissociated protein 1	RBX1;CUL2;CAND1	RNF75 ROC1;None;KIAA0829 TIP120 TIP120A
222	CAND1-CUL3-RBX1 complex	Human	None	None	P62877;Q13618;Q86VP6	9978;8452;55832	MI:0007-anti tag coimmunoprecipitation	GO:0010265;GO:0051444	SCF complex assembly;negative regulation of ubiquitin-protein transferase activity	None	None	12609982	Binding of Cand1 to cullins inhibits the formation of E3 protein-ubiquitin ligases.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase RBX1;Cullin-3;Cullin-associated NEDD8-dissociated protein 1	RBX1;CUL3;CAND1	RNF75 ROC1;KIAA0617;KIAA0829 TIP120 TIP120A
223	CAND1-CUL4A-RBX1 complex	Human	None	None	P62877;Q13619;Q86VP6	9978;8451;55832	MI:0007-anti tag coimmunoprecipitation	GO:0010265;GO:0051444	SCF complex assembly;negative regulation of ubiquitin-protein transferase activity	None	None	12609982	Binding of Cand1 to cullins inhibits the formation of E3 protein-ubiquitin ligases.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase RBX1;Cullin-4A;Cullin-associated NEDD8-dissociated protein 1	RBX1;CUL4A;CAND1	RNF75 ROC1;None;KIAA0829 TIP120 TIP120A
224	CAND1-CUL4B-RBX1 complex	Human	None	None	P62877;Q13620;Q86VP6	9978;8450;55832	MI:0007-anti tag coimmunoprecipitation	GO:0010265;GO:0051444	SCF complex assembly;negative regulation of ubiquitin-protein transferase activity	None	None	12609982	Binding of Cand1 to cullins inhibits the formation of E3 protein-ubiquitin ligases.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase RBX1;Cullin-4B;Cullin-associated NEDD8-dissociated protein 1	RBX1;CUL4B;CAND1	RNF75 ROC1;KIAA0695;KIAA0829 TIP120 TIP120A
226	Ubiquitin E3 ligase (SKP1A, SKP2, CUL1)	Human	SKP1-SKP2-CUL1 complex	None	P63208;Q13309;Q13616	6500;6502;8454	MI:0007-anti tag coimmunoprecipitation	GO:0016567;GO:0005515;GO:0006511	protein ubiquitination;protein binding;ubiquitin-dependent protein catabolic process	14.07.05;16.01;14.13.01.01	modification by ubiquitination, deubiquitination;protein binding;proteasomal degradation (ubiquitin/proteasomal pathway)	12609982	Ubiquitin E3 ligases covalently attach ubiquitin to a lysine residue on a target protein. Polyubiquitination marks proteins for degradation by the proteasome.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	S-phase kinase-associated protein 1;S-phase kinase-associated protein 2;Cullin-1	SKP1;SKP2;CUL1	EMC19 OCP2 SKP1A TCEB1L;FBXL1;None
227	Ubiquitin E3 ligase (SKP1A, BTRC, CUL1)	Human	SCF(beta-TrCP) complex; SKP1-CUL1-beta-TrCP complex; SKP1-CUL1-BTRC1 complex	HEK293T cells	P63208;Q13616;Q9Y297	6500;8454;8945	MI:0007-anti tag coimmunoprecipitation	GO:0016567;GO:0043161;GO:0045087;GO:0051607;GO:0043123;GO:0051092;GO:0019048	protein ubiquitination;proteasome-mediated ubiquitin-dependent protein catabolic process;innate immune response;defense response to virus;positive regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of NF-kappaB transcription factor activity;modulation by virus of host process	14.07.05;14.13.01.01;36.25.16.01	modification by ubiquitination, deubiquitination;proteasomal degradation (ubiquitin/proteasomal pathway);innate immune response (invertebrates and vertebrates)	9990852	The SKP1A-BTRC-CUL1 complex is responsible for proteasome-mediated degradation of IkappB(alpha) required for NFkappB activation (PMID:9990852). The complex plays essential roles in a variety of biological processes, including also innate immune response. Viruses have evolved several strategies to evade the immune system of the host. Infection with porcine rotavirus strain OSU leads to inhibition of  NFkappaB activation by inducing proteasome-dependent degradation of BTRC protein leading to impaired SKP1A-BTRC-CUL1 complex formation. (PMID: 19180189)	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	S-phase kinase-associated protein 1;Cullin-1;F-box/WD repeat-containing protein 1A	SKP1;CUL1;BTRC	EMC19 OCP2 SKP1A TCEB1L;None;BTRCP FBW1A FBXW1A
228	SMCC complex	Human	SRB/MED-containing cofactor complex	None	O60244;O75448;O75586;P24863;P49336;Q13503;Q15648;Q9Y3C7	9282;9862;10001;892;1024;9412;5469;51003	MI:0007-anti tag coimmunoprecipitation	GO:0045893;GO:0045892;GO:0005634	positive regulation of DNA-templated transcription;negative regulation of DNA-templated transcription;nucleus	11.02.03.04.01;11.02.03.04.03;70.10	transcription activation;transcription repression;nucleus	10024883	Several identical subunits appear in protein complexes like DRIP/ARC, CRSP, NAT, PC2, SMCC and Mediator, indicating that unique classes of transcription activators may share common sets or subsets of cofactors.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mediator of RNA polymerase II transcription subunit 14;Mediator of RNA polymerase II transcription subunit 24;Mediator of RNA polymerase II transcription subunit 6;Cyclin-C;Cyclin-dependent kinase 8;Mediator of RNA polymerase II transcription subunit 21;Mediator of RNA polymerase II transcription subunit 1;Mediator of RNA polymerase II transcription subunit 31	MED14;MED24;MED6;CCNC;CDK8;MED21;MED1;MED31	ARC150 CRSP2 CXorf4 DRIP150 EXLM1 RGR1 TRAP170;ARC100 CRSP4 DRIP100 KIAA0130 THRAP4 TRAP100;ARC33;None;None;SRB7 SURB7;ARC205 CRSP1 CRSP200 DRIP205 DRIP230 PBP PPARBP PPARGBP RB18A TRAP220 TRIP2;SOH1
229	NAT complex	Human	None	None	O60244;O75586;P24863;P49336;Q13503;Q9BTT4;Q9ULK4	9282;10001;892;1024;9412;84246;9439	MI:0019-coimmunoprecipitation	GO:0045892;GO:0005515;GO:0005634	negative regulation of DNA-templated transcription;protein binding;nucleus	11.02.03.04.03;16.01;70.10	transcription repression;protein binding;nucleus	9734358	A complex, NAT, that represses activation of transcription by RNAPII has been isolated. The NAT complex is composed of approximately 20 polypeptides and includes a subset of the Srb polypeptides, hSrb7, hSrb10, and hSrb11, as well as hRgr1 and hMed6. The presence of hSrb10, hSrb11, and hRgr1 in a complex that functions to down-regulate transcription is consistent with studies in yeast demonstrating that Srb8-Srb11, as well as Rgr1, function as negative regulators of transcription in vivo. It has been suggested that the NAT complex is a subcomplex of the RNAPII holoenzyme and its function and regulation is through the RNAPII holoenzyme. Several identical subunits appear in protein complexes like DRIP/ARC, CRSP, NAT, PC2, SMCC and Mediator, indicating that unique classes of transcription activators may share common sets or subsets of cofactors.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mediator of RNA polymerase II transcription subunit 14;Mediator of RNA polymerase II transcription subunit 6;Cyclin-C;Cyclin-dependent kinase 8;Mediator of RNA polymerase II transcription subunit 21;Mediator of RNA polymerase II transcription subunit 10;Mediator of RNA polymerase II transcription subunit 23	MED14;MED6;CCNC;CDK8;MED21;MED10;MED23	ARC150 CRSP2 CXorf4 DRIP150 EXLM1 RGR1 TRAP170;ARC33;None;None;SRB7 SURB7;None;ARC130 CRSP3 DRIP130 KIAA1216 SUR2
230	Mediator complex	Human	Mediator of transcriptional regulation	None	A0JLT2;O43513;O60244;O75448;O75586;O95402;P24863;P49336;Q13503;Q15528;Q15648;Q6P2C8;Q71F56;Q71SY5;Q93074;Q96G25;Q96HR3;Q96RN5;Q9BTT4;Q9BUE0;Q9BWU1;Q9H204;Q9H944;Q9NPJ6;Q9NVC6;Q9NWA0;Q9NX70;Q9P086;Q9UHV7;Q9ULK4;Q9Y2X0;Q9Y3C7	219541;9443;9282;9862;10001;9441;892;1024;9412;6837;5469;9442;23389;81857;9968;112950;90390;51586;84246;54797;23097;80306;9477;29079;9440;55090;55588;400569;9969;9439;10025;51003	MI:0007-anti tag coimmunoprecipitation;MI:0069-mass spectrometry studies of complexes	GO:0045893;GO:0005634	positive regulation of DNA-templated transcription;nucleus	11.02.03.04.01;70.10	transcription activation;nucleus	15175163	Regulation of transcription by RNA polymerase II (Pol II) is controlled by specific combinations of sequence-specific, DNA binding regulatory transcription factors (TFs) bound to a gene's promoter and enhancer regions. These TFs interact with several multiprotein complexes that remodel the chromatin context of the promoter, integrate signals from multiple TFs to control the frequency of transcription initiation, and regulate the efficiency of transcription elongation. One such complex is the Mediator, an ~2-megadalton complex of 20 to 30 subunits that is believed to function as a molecular bridge by simultaneously interacting with both DNA-bound TFs and Pol II. Several identical subunits appear in protein complexes like DRIP/ARC, CRSP, NAT, PC2, SMCC and Mediator, indicating that unique classes of transcription activators may share common sets or subsets of cofactors.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mediator of RNA polymerase II transcription subunit 19;Mediator of RNA polymerase II transcription subunit 7;Mediator of RNA polymerase II transcription subunit 14;Mediator of RNA polymerase II transcription subunit 24;Mediator of RNA polymerase II transcription subunit 6;Mediator of RNA polymerase II transcription subunit 26;Cyclin-C;Cyclin-dependent kinase 8;Mediator of RNA polymerase II transcription subunit 21;Mediator of RNA polymerase II transcription subunit 22;Mediator of RNA polymerase II transcription subunit 1;Mediator of RNA polymerase II transcription subunit 27;Mediator of RNA polymerase II transcription subunit 13-like;Mediator of RNA polymerase II transcription subunit 25;Mediator of RNA polymerase II transcription subunit 12;Mediator of RNA polymerase II transcription subunit 8;Mediator of RNA polymerase II transcription subunit 30;Mediator of RNA polymerase II transcription subunit 15;Mediator of RNA polymerase II transcription subunit 10;Mediator of RNA polymerase II transcription subunit 18;Cyclin-dependent kinase 19;Mediator of RNA polymerase II transcription subunit 28;Mediator of RNA polymerase II transcription subunit 20;Mediator of RNA polymerase II transcription subunit 4;Mediator of RNA polymerase II transcription subunit 17;Mediator of RNA polymerase II transcription subunit 9;Mediator of RNA polymerase II transcription subunit 29;Mediator of RNA polymerase II transcription subunit 11;Mediator of RNA polymerase II transcription subunit 13;Mediator of RNA polymerase II transcription subunit 23;Mediator of RNA polymerase II transcription subunit 16;Mediator of RNA polymerase II transcription subunit 31	MED19;MED7;MED14;MED24;MED6;MED26;CCNC;CDK8;MED21;MED22;MED1;MED27;MED13L;MED25;MED12;MED8;MED30;MED15;MED10;MED18;CDK19;MED28;MED20;MED4;MED17;MED9;MED29;MED11;MED13;MED23;MED16;MED31	LCMR1;ARC34 CRSP9;ARC150 CRSP2 CXorf4 DRIP150 EXLM1 RGR1 TRAP170;ARC100 CRSP4 DRIP100 KIAA0130 THRAP4 TRAP100;ARC33;ARC70 CRSP7;None;None;SRB7 SURB7;SURF5;ARC205 CRSP1 CRSP200 DRIP205 DRIP230 PBP PPARBP PPARGBP RB18A TRAP220 TRIP2;CRSP34 CRSP8;KIAA1025 PROSIT240 THRAP2 TRAP240L;ACID1 ARC92 PTOV2;ARC240 CAGH45 HOPA KIAA0192 TNRC11 TRAP230;None;THRAP6 TRAP25;ARC105 CTG7A PCQAP TIG1 TNRC7;None;None;CDC2L6 CDK11 KIAA1028;EG1;TRFP;ARC36 DRIP36 VDRIP;ARC77 CRSP6 DRIP77 DRIP80 TRAP80;MED25;IXL;None;ARC250 KIAA0593 THRAP1 TRAP240;ARC130 CRSP3 DRIP130 KIAA1216 SUR2;DRIP92 THRAP5;SOH1
232	ARC complex	Human	activator-recruited cofactor	None	O43513;O60244;O75448;O75586;O95402;Q15648;Q71SY5;Q93074;Q96G25;Q96RN5;Q9NPJ6;Q9NVC6;Q9UHV7;Q9UKU7;Q9ULK4	9443;9282;9862;10001;9441;5469;81857;9968;112950;51586;29079;9440;9969;27034;9439	MI:0004-affinity chromatography technology	GO:0045893;GO:0005515;GO:0035556;GO:0005634	positive regulation of DNA-templated transcription;protein binding;intracellular signal transduction;nucleus	11.02.03.04.01;16.01;30.01;70.10	transcription activation;protein binding;cellular signalling;nucleus	10235267	Experiments show that the transcription coactivator ARC is required for SREBP (sterol regulatory element binding protein) control of cholesterol and lipid homeostasis. Several identical subunits appear in protein complexes like DRIP/ARC, CRSP, NAT, PC2, SMCC and Mediator, indicating that unique classes of transcription activators may share common sets or subsets of cofactors. According to authors, the ARC complex is probably identical to the DRIP complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mediator of RNA polymerase II transcription subunit 7;Mediator of RNA polymerase II transcription subunit 14;Mediator of RNA polymerase II transcription subunit 24;Mediator of RNA polymerase II transcription subunit 6;Mediator of RNA polymerase II transcription subunit 26;Mediator of RNA polymerase II transcription subunit 1;Mediator of RNA polymerase II transcription subunit 25;Mediator of RNA polymerase II transcription subunit 12;Mediator of RNA polymerase II transcription subunit 8;Mediator of RNA polymerase II transcription subunit 15;Mediator of RNA polymerase II transcription subunit 4;Mediator of RNA polymerase II transcription subunit 17;Mediator of RNA polymerase II transcription subunit 13;Isobutyryl-CoA dehydrogenase, mitochondrial;Mediator of RNA polymerase II transcription subunit 23	MED7;MED14;MED24;MED6;MED26;MED1;MED25;MED12;MED8;MED15;MED4;MED17;MED13;ACAD8;MED23	ARC34 CRSP9;ARC150 CRSP2 CXorf4 DRIP150 EXLM1 RGR1 TRAP170;ARC100 CRSP4 DRIP100 KIAA0130 THRAP4 TRAP100;ARC33;ARC70 CRSP7;ARC205 CRSP1 CRSP200 DRIP205 DRIP230 PBP PPARBP PPARGBP RB18A TRAP220 TRIP2;ACID1 ARC92 PTOV2;ARC240 CAGH45 HOPA KIAA0192 TNRC11 TRAP230;None;ARC105 CTG7A PCQAP TIG1 TNRC7;ARC36 DRIP36 VDRIP;ARC77 CRSP6 DRIP77 DRIP80 TRAP80;ARC250 KIAA0593 THRAP1 TRAP240;ARC42, IBD;ARC130 CRSP3 DRIP130 KIAA1216 SUR2
234	HuCHRAC complex	Human	None	None	O60264;Q9NRF9;Q9NRG0;Q9NRL2	8467;54107;54108;11177	MI:0226-ion exchange chromatography	GO:0006265;GO:0005515;GO:0003677;GO:0005524;GO:0005634	DNA topological change;protein binding;DNA binding;ATP binding;nucleus	10.01.09.05;16.01;16.03.01;16.19.03;70.10	DNA conformation modification (e.g. chromatin);protein binding;DNA binding;ATP binding;nucleus	10880450	HuCHRAC is a member of the ISWI-containing chromatin remodelling complexes. The polyclonal antibodies against ISWI do not discriminate between hSNF2L and hSNF2H.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5;DNA polymerase epsilon subunit 3;Chromatin accessibility complex protein 1;Bromodomain adjacent to zinc finger domain protein 1A	SMARCA5;POLE3;CHRAC1;BAZ1A	SNF2H, WCRF135;CHRAC17;CHRAC15;ACF1, WCRF180
236	WICH complex	Human	WSTF-ISWI chromatin remodeling complex	HeLa cell nuclear extracts	O60264;Q9UIG0	8467;9031	MI:0096-pull down	GO:0006265;GO:0005515;GO:0003677;GO:0005524;GO:0005694	DNA topological change;protein binding;DNA binding;ATP binding;chromosome	10.01.09.05;16.01;16.03.01;16.19.03;70.10.03	DNA conformation modification (e.g. chromatin);protein binding;DNA binding;ATP binding;chromosome	11980720	WICH is a member of the ISWI-containing chromatin remodelling complexes.	None	None	Homo sapiens (Human);Homo sapiens (Human)	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5;Tyrosine-protein kinase BAZ1B	SMARCA5;BAZ1B	SNF2H, WCRF135;WBSC10 WBSCR10 WBSCR9 WSTF
238	SWI-SNF chromatin remodeling-related-BRCA1 complex	Human	None	HeLa cells	O14497;O96019;P38398;P51531;P51532;Q12824;Q8TAQ2;Q92922;Q92925;Q969G3	8289;86;672;6595;6597;6598;6601;6599;6603;6605	MI:0004-affinity chromatography technology;MI:0071-molecular sieving	GO:0006265;GO:2001141;GO:0006355;GO:0051276;GO:0005634	DNA topological change;regulation of RNA biosynthetic process;regulation of DNA-templated transcription;chromosome organization;nucleus	10.01.09.05;11.02.03.04;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcriptional control;organization of chromosome structure;nucleus	10943845	BRCA1 interacts directly with BRG1.	BRCA1 gene is involved in breast and ovarian cancers.	Since the authors did not specify Actin-like protein 6, we used isoform ACTL6A.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	AT-rich interactive domain-containing protein 1A;Actin-like protein 6A;Breast cancer type 1 susceptibility protein;Probable global transcription activator SNF2L2;Transcription activator BRG1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1;SWI/SNF complex subunit SMARCC2;SWI/SNF complex subunit SMARCC1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1	ARID1A;ACTL6A;BRCA1;SMARCA2;SMARCA4;SMARCB1;SMARCC2;SMARCC1;SMARCD2;SMARCE1	BAF250 BAF250A C1orf4 OSA1 SMARCF1;BAF53 BAF53A INO80K;RNF53;BAF190B BRM SNF2A SNF2L2;BAF190A BRG1 SNF2B SNF2L4;BAF47, INI1, SNF5L1;BAF170;BAF155;BAF60B;BAF57
240	BRCA1-CTIP-ZBRK1 repressor complex	Human	None	None	P38398;Q99708;Q9GZX5	672;5932;59348	MI:0006-anti bait coimmunoprecipitation	GO:0045892;GO:0003677;GO:0005634	negative regulation of DNA-templated transcription;DNA binding;nucleus	11.02.03.04.03;16.03.01;70.10	transcription repression;DNA binding;nucleus	16843262	None	BRCA1 is involved in breast cancer.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Breast cancer type 1 susceptibility protein;DNA endonuclease RBBP8;Zinc finger protein 350	BRCA1;RBBP8;ZNF350	RNF53;CTIP;ZBRK1
242	BRCA1-BACH1 complex	Human	None	None	P38398;Q9BX63	672;83990	MI:0006-anti bait coimmunoprecipitation	GO:0006281;GO:0005634	DNA repair;nucleus	10.01.05.01;70.10	DNA repair;nucleus	11301010	An intact BRCA1 C-terminal region is necessary for the interaction with BACH1.	BRCA1 is involved in breast cancer.	None	Homo sapiens (Human);Homo sapiens (Human)	Breast cancer type 1 susceptibility protein;Fanconi anemia group J protein	BRCA1;BRIP1	RNF53;BACH1 FANCJ
243	RalBP1-CDC2-CCNB1 complex	Human	None	None	P06493;P14635;Q15311	983;891;10928	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0000278;GO:0006468;GO:0005634	mitotic cell cycle;protein phosphorylation;nucleus	10.03.01.01;14.07.03;70.10	mitotic cell cycle;modification by phosphorylation, dephosphorylation, autophosphorylation;nucleus	12775724	The complex was only detected in mitotic cell extracts. The authors show that RLIP76 associates with a catalytically active cyclinB\u00b7p34cdc2(cdk1) complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cyclin-dependent kinase 1;G2/mitotic-specific cyclin-B1;RalA-binding protein 1	CDK1;CCNB1;RALBP1	CDC2 CDC28A CDKN1 P34CDC2;CCNB;RLIP RLIP1 RLIP76
244	BRAFT complex	Human	BLM complex I	None	O15287;O15360;P15927;P27694;P35244;P40692;P54132;Q00597;Q13472;Q9H9A7;Q9HB96;Q9NPI8;Q9NW38	2189;2175;6118;6117;6119;4292;641;2176;7156;80010;2178;2188;55120	MI:0006-anti bait coimmunoprecipitation	GO:0051276;GO:0006281;GO:0006974;GO:0005634	chromosome organization;DNA repair;cellular response to DNA damage stimulus;nucleus	42.10.03;10.01.05.01;32.01.09;70.10	organization of chromosome structure;DNA repair;DNA damage response;nucleus	12724401	None	BRAFT complex is involved in Fanconi Anemia (FA) and Bloom Syndrome (BS).	The BRAFT complex contains several other proteins of unknown function, called FAAPs or BLAPs. FAAP 43 has been identified as FANCL/PHF9 in a following paper (PMID:12973351).	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Fanconi anemia group G protein;Fanconi anemia group A protein;Replication protein A 32 kDa subunit;Replication protein A 70 kDa DNA-binding subunit;Replication protein A 14 kDa subunit;DNA mismatch repair protein Mlh1;RecQ-like DNA helicase BLM;Fanconi anemia group C protein;DNA topoisomerase 3-alpha;RecQ-mediated genome instability protein 1;Fanconi anemia group E protein;Fanconi anemia group F protein;E3 ubiquitin-protein ligase FANCL	FANCG;FANCA;RPA2;RPA1;RPA3;MLH1;BLM;FANCC;TOP3A;RMI1;FANCE;FANCF;FANCL	XRCC9;FAA FACA FANCH;REPA2 RPA32 RPA34;REPA1 RPA70;REPA3 RPA14;COCA2;RECQ2 RECQL3;FAC FACC;TOP3;C9orf76;FACE;None;PHF9
245	FA core complex (Fanconi anemia core complex)	Human	None	None	O15287;O15360;Q00597;Q0VG06;Q8NB91;Q9H9A7;Q9HB96;Q9NPI8;Q9NW38	2189;2175;2176;80233;2187;80010;2178;2188;55120	MI:0006-anti bait coimmunoprecipitation	GO:0016567;GO:0016579;GO:0006974;GO:0005634	protein ubiquitination;protein deubiquitination;cellular response to DNA damage stimulus;nucleus	14.07.05;32.01.09;70.10	modification by ubiquitination, deubiquitination;DNA damage response;nucleus	12724401	None	FA complex is involved in Fanconi anemia (FA) disease.	FANCB and FANCL have been designated as FAAP90 and FAAP43. RMI1 has been designated as FAAP75.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Fanconi anemia group G protein;Fanconi anemia group A protein;Fanconi anemia group C protein;Fanconi anemia core complex-associated protein 100;Fanconi anemia group B protein;RecQ-mediated genome instability protein 1;Fanconi anemia group E protein;Fanconi anemia group F protein;E3 ubiquitin-protein ligase FANCL	FANCG;FANCA;FANCC;FAAP100;FANCB;RMI1;FANCE;FANCF;FANCL	XRCC9;FAA FACA FANCH;FAC FACC;C17orf70;None;C9orf76;FACE;None;PHF9
246	BLM complex III	Human	BLM-CIII complex	None	P40692;P54132;Q13472;Q9H9A7	4292;641;7156;80010	MI:0006-anti bait coimmunoprecipitation	GO:0051276;GO:0006281;GO:0006974;GO:0005634	chromosome organization;DNA repair;cellular response to DNA damage stimulus;nucleus	42.10.03;10.01.05.01;32.01.09;70.10	organization of chromosome structure;DNA repair;DNA damage response;nucleus	12724401	None	BLM complex III is involved in Bloom syndrome (BS).	Another subunit of the complex was found in the analysis, which has not been further characterized: BLAPp100.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA mismatch repair protein Mlh1;RecQ-like DNA helicase BLM;DNA topoisomerase 3-alpha;RecQ-mediated genome instability protein 1	MLH1;BLM;TOP3A;RMI1	COCA2;RECQ2 RECQL3;TOP3;C9orf76
247	RalBP1-CCNB1-AP2A-NUMB-EPN1 complex	Human	None	None	O95782;P14635;P49757;Q15311;Q9Y6I3	160;891;8650;10928;29924	MI:0019-coimmunoprecipitation	GO:0000278;GO:0006897;GO:0005634	mitotic cell cycle;endocytosis;nucleus	10.03.01.01;20.09.18.09.01;70.10	mitotic cell cycle;endocytosis;nucleus	12775724	RLIP, an effector of the RAL GTPases, is important for the mitotic cdk1 to facilitate the phosphorylation of Epsin.	None	Since the authors did not specify AP2A, we used isoform AP2A1.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	AP-2 complex subunit alpha-1;G2/mitotic-specific cyclin-B1;Protein numb homolog;RalA-binding protein 1;Epsin-1	AP2A1;CCNB1;NUMB;RALBP1;EPN1	ADTAA CLAPA1;CCNB;C14orf41;RLIP RLIP1 RLIP76;None
248	BRAFT complex	Human	None	HeLa cells	O15287;O15360;P15927;P27694;P35244;P54132;Q00597;Q13472;Q9HB96;Q9NPI8;Q9NW38	2189;2175;6118;6117;6119;641;2176;7156;2178;2188;55120	MI:0006-anti bait coimmunoprecipitation	GO:0051276;GO:0006281;GO:0016567;GO:0006974;GO:0005634	chromosome organization;DNA repair;protein ubiquitination;cellular response to DNA damage stimulus;nucleus	42.10.03;10.01.05.01;14.07.05;32.01.09;70.10	organization of chromosome structure;DNA repair;modification by ubiquitination, deubiquitination;DNA damage response;nucleus	12973351	None	None	FANCL/PHF9 (formerly called FAAP 43) is a newly identified component of the BRAFT complex.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Fanconi anemia group G protein;Fanconi anemia group A protein;Replication protein A 32 kDa subunit;Replication protein A 70 kDa DNA-binding subunit;Replication protein A 14 kDa subunit;RecQ-like DNA helicase BLM;Fanconi anemia group C protein;DNA topoisomerase 3-alpha;Fanconi anemia group E protein;Fanconi anemia group F protein;E3 ubiquitin-protein ligase FANCL	FANCG;FANCA;RPA2;RPA1;RPA3;BLM;FANCC;TOP3A;FANCE;FANCF;FANCL	XRCC9;FAA FACA FANCH;REPA2 RPA32 RPA34;REPA1 RPA70;REPA3 RPA14;RECQ2 RECQL3;FAC FACC;TOP3;FACE;None;PHF9
254	TBPIP/HOP2-MND1 complex	Human	None	testis	Q9BWT6;Q9P2W1	84057;29893	MI:0004-affinity chromatography technology	GO:0007131;GO:0000280;GO:0007059;GO:0003677;GO:0005515;GO:0005634;GO:0051321	reciprocal meiotic recombination;nuclear division;chromosome segregation;DNA binding;protein binding;nucleus;meiotic cell cycle	10.01.05.03.01;10.03.04.07;10.03.04.05;16.03.01;16.01;70.10	meiotic recombination;nuclear division;chromosome segregation/division;DNA binding;protein binding;nucleus	16407260	The complex ensures proper pairing between homologous chromosomes.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Meiotic nuclear division protein 1 homolog;Homologous-pairing protein 2 homolog	MND1;PSMC3IP	GAJ;HOP2 TBPIP
256	RAD51B-RAD51C complex	Human	None	HeLa cells	O15315;O43502	5890;5889	MI:0006-anti bait coimmunoprecipitation	GO:0006281;GO:0006310;GO:0003677;GO:0005524;GO:0005634	DNA repair;DNA recombination;DNA binding;ATP binding;nucleus	10.01.05.01;10.01.05.03;16.03.01;16.19.03;70.10	DNA repair;DNA recombination;DNA binding;ATP binding;nucleus	11751636	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	DNA repair protein RAD51 homolog 2;DNA repair protein RAD51 homolog 3	RAD51B;RAD51C	RAD51L1 REC2;RAD51L2
261	RAD51B-RAD51C-RAD51D-XRCC2-XRCC3 complex	Human	None	HeLa cells	O15315;O43502;O43542;O43543;O75771	5890;5889;7517;7516;5892	MI:0006-anti bait coimmunoprecipitation	GO:0006281;GO:0006310;GO:0003677;GO:0005524;GO:0006974;GO:0005634	DNA repair;DNA recombination;DNA binding;ATP binding;cellular response to DNA damage stimulus;nucleus	10.01.05.01;10.01.05.03;16.03.01;16.19.03;32.01.09;70.10	DNA repair;DNA recombination;DNA binding;ATP binding;DNA damage response;nucleus	11744692	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA repair protein RAD51 homolog 2;DNA repair protein RAD51 homolog 3;DNA repair protein XRCC3;DNA repair protein XRCC2;DNA repair protein RAD51 homolog 4	RAD51B;RAD51C;XRCC3;XRCC2;RAD51D	RAD51L1 REC2;RAD51L2;None;None;RAD51L3
262	RAD51L3-XRCC2 complex	Human	None	HeLa cells	O43543;O75771	7516;5892	MI:0096-pull down	GO:0006281;GO:0006310;GO:0003677;GO:0005524;GO:0006974;GO:0005634	DNA repair;DNA recombination;DNA binding;ATP binding;cellular response to DNA damage stimulus;nucleus	10.01.05.01;10.01.05.03;16.03.01;16.19.03;32.01.09;70.10	DNA repair;DNA recombination;DNA binding;ATP binding;DNA damage response;nucleus	10871607	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	DNA repair protein XRCC2;DNA repair protein RAD51 homolog 4	XRCC2;RAD51D	None;RAD51L3
265	ATR-ATRIP complex	Human	None	None	Q13535;Q8WXE1	545;84126	MI:0071-molecular sieving;MI:0091-chromatography technology	GO:0000075;GO:0003677;GO:0006974;GO:0005634	cell cycle checkpoint signaling;DNA binding;cellular response to DNA damage stimulus;nucleus	10.03.01.03;16.03.01;32.01.09;70.10	cell cycle checkpoints (checkpoints of morphogenesis, DNA-damage,-replication, mitotic phase and spindle);DNA binding;DNA damage response;nucleus	14724280	ATR and ATRIP associate with chromatin in vivo, and they exist as a large molecular weight complex that can bind single-stranded (ss)DNA cellulose in vitro. Neither ATR nor ATRIP are able to bind DNA individually, nor do they bind DNA in a cooperative manner.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein kinase ATR;ATR-interacting protein	ATR;ATRIP	FRP1;AGS1
266	RAD17-RFC complex	Human	None	HeLa cells	O75943;P35249;P35250;P40937;P40938	5884;5984;5982;5985;5983	MI:0004-affinity chromatography technology;MI:0006-anti bait coimmunoprecipitation	GO:0000075;GO:0003677;GO:0005524;GO:0006974;GO:0005634	cell cycle checkpoint signaling;DNA binding;ATP binding;cellular response to DNA damage stimulus;nucleus	10.03.01.03;16.03.01;16.19.03;32.01.09;70.10	cell cycle checkpoints (checkpoints of morphogenesis, DNA-damage,-replication, mitotic phase and spindle);DNA binding;ATP binding;DNA damage response;nucleus	11572977	RFCp38 is necessary for the association of RAD17 with the core complex RFCp36-p37-p40 to form the RAD17-RFC complex. The ATPase activity of RAD17-RFC complex is stimulated by DNA.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cell cycle checkpoint protein RAD17;Replication factor C subunit 4;Replication factor C subunit 2;Replication factor C subunit 5;Replication factor C subunit 3	RAD17;RFC4;RFC2;RFC5;RFC3	R24L;None;None;None;None
271	9-1-1 complex	Human	Checkpoint 9-1-1 complex	HeLa cells	O60671;O60921;Q99638	5810;3364;5883	MI:0004-affinity chromatography technology;MI:0040-electron microscopy	GO:0006281;GO:0000075;GO:0006974;GO:0005634	DNA repair;cell cycle checkpoint signaling;cellular response to DNA damage stimulus;nucleus	10.01.05.01;10.03.01.03;32.01.09;70.10	DNA repair;cell cycle checkpoints (checkpoints of morphogenesis, DNA-damage,-replication, mitotic phase and spindle);DNA damage response;nucleus	11907025	The checkpoint 9-1-1 complex makes a trimeric ring structure reminiscent of the PCNA ring.	None	This complex has been also isolated from K562 cells. (PMID:9872989)	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cell cycle checkpoint protein RAD1;Checkpoint protein HUS1;Cell cycle checkpoint control protein RAD9A	RAD1;HUS1;RAD9A	REC1;None;None
274	9-1-1-RAD17-RFC complex	Human	RAD17-RFC-9-1-1 checkpoint supercomplex	in vitro, human cells expressed in H5 cells	O60671;O60921;O75943;P35249;P35250;P40937;P40938;Q99638	5810;3364;5884;5984;5982;5985;5983;5883	MI:0004-affinity chromatography technology;MI:0029-cosedimentation through density gradient;MI:0040-electron microscopy	GO:0000077;GO:0003677;GO:0006974	DNA damage checkpoint signaling;DNA binding;cellular response to DNA damage stimulus	16.03.01;32.01.09	DNA binding;DNA damage response	12578958	Rad17-RFC complex binds to nicked circular, gapped and primed DNA and recruits the 9-1-1 complex in an ATP-dependent manner. The interaction is mediated mainly by binding of Rad9 to Rad17.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cell cycle checkpoint protein RAD1;Checkpoint protein HUS1;Cell cycle checkpoint protein RAD17;Replication factor C subunit 4;Replication factor C subunit 2;Replication factor C subunit 5;Replication factor C subunit 3;Cell cycle checkpoint control protein RAD9A	RAD1;HUS1;RAD17;RFC4;RFC2;RFC5;RFC3;RAD9A	REC1;None;R24L;None;None;None;None;None
278	RFC core complex	Human	None	in vitro	P35249;P35250;P40937	5984;5982;5985	MI:0006-anti bait coimmunoprecipitation	GO:0006260;GO:0003677;GO:0005524;GO:0005634	DNA replication;DNA binding;ATP binding;nucleus	10.01.03;16.03.01;16.19.03;70.10	DNA synthesis and replication;DNA binding;ATP binding;nucleus	8692848	The subunits of the RFC complex have been reconstituted in an in vitro experiment.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Replication factor C subunit 4;Replication factor C subunit 2;Replication factor C subunit 5	RFC4;RFC2;RFC5	None;None;None
279	RFC complex	Human	Activator A 1 complex	None	P35249;P35250;P35251;P40937;P40938	5984;5982;5981;5985;5983	MI:0029-cosedimentation through density gradient	GO:0006260;GO:0003677;GO:0005524;GO:0005634;GO:0000075;GO:0006281	DNA replication;DNA binding;ATP binding;nucleus;cell cycle checkpoint signaling;DNA repair	10.01.03;16.03.01;16.19.03;70.10;10.03.01.03;10.01.05.01	DNA synthesis and replication;DNA binding;ATP binding;nucleus;cell cycle checkpoints (checkpoints of morphogenesis, DNA-damage,-replication, mitotic phase and spindle);DNA repair	1670772	Activator 1 (A1) is a multiprotein complex which is essential for proliferating cell nuclear antigen (PCNA)-dependent DNA polymerase delta (pol delta) activity and efficient in vitro DNA synthesis in the SV40 dipolymerase replication system (PMID:1670772). Assembly of RFC complex involves distinct subunit interations: RFC5 and RFC3 interact with the RFC4 subunit and RFC2 interacts with RFC5 and RFC4. RFC1 interacts primarily with RFC3 and RFC2. RFC complex functions as clamp loader. The complex is necessary for loading of PCNA onto dsDNA. (PMID: 9488738)	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Replication factor C subunit 4;Replication factor C subunit 2;Replication factor C subunit 1;Replication factor C subunit 5;Replication factor C subunit 3	RFC4;RFC2;RFC1;RFC5;RFC3	None;None;RFC140;None;None
280	HMGB1-HMGB2-HSC70-ERP60-GAPDH complex	Human	None	None	P04406;P09429;P11142;P26583;P30101	2597;3146;3312;3148;2923	MI:0413-electrophoretic mobility shift assay	GO:0006281;GO:0003677;GO:0006974;GO:0005634	DNA repair;DNA binding;cellular response to DNA damage stimulus;nucleus	10.01.05.01;16.03.01;32.01.09;70.10	DNA repair;DNA binding;DNA damage response;nucleus	12517784	The protein/DNA complex was isolated from human leukemia cells deficient in components of the mismatch repair system (Nalm6). This complex detects changes in DNA structure caused by incorporation of nonnatural nucleosides and is a determinant of cell sensitivity to such DNA modifying chemotherapy. The authors show that murine fibroblasts deficient in one component of the complex, Hmgb1, are 10-fold more resistant to thiopurine treatment than their wild-type counterparts.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Glyceraldehyde-3-phosphate dehydrogenase;High mobility group protein B1;Heat shock cognate 71 kDa protein;High mobility group protein B2;Protein disulfide-isomerase A3	GAPDH;HMGB1;HSPA8;HMGB2;PDIA3	GAPD;HMG1;HSC70 HSP73 HSPA10;HMG2;ERP57 ERP60 GRP58
282	SNF2h-cohesin-NuRD complex	Human	ISWI (SNF2h)-containing chromatin remodeling complex	None	O60216;O60264;O94776;O95983;Q09028;Q12873;Q13330;Q13547;Q14683;Q16576;Q8N3U4;Q8WVM7;Q92769;Q9NRL2;Q9UBB5;Q9UQE7	5885;8467;9219;53615;5928;1107;9112;3065;8243;5931;10735;10274;3066;11177;8932;9126	MI:0071-molecular sieving;MI:0226-ion exchange chromatography	GO:0006265;GO:0003677;GO:0051276;GO:0005694	DNA topological change;DNA binding;chromosome organization;chromosome	10.01.09.05;16.03.01;42.10.03;70.10.03	DNA conformation modification (e.g. chromatin);DNA binding;organization of chromosome structure;chromosome	12198550	The association of the complex with chromatin can be regulated by the state of DNA methylation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Double-strand-break repair protein rad21 homolog;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5;Metastasis-associated protein MTA2;Methyl-CpG-binding domain protein 3;Histone-binding protein RBBP4;Chromodomain-helicase-DNA-binding protein 3;Metastasis-associated protein MTA1;Histone deacetylase 1;Structural maintenance of chromosomes protein 1A;Histone-binding protein RBBP7;Cohesin subunit SA-2;Cohesin subunit SA-1;Histone deacetylase 2;Bromodomain adjacent to zinc finger domain protein 1A;Methyl-CpG-binding domain protein 2;Structural maintenance of chromosomes protein 3	RAD21;SMARCA5;MTA2;MBD3;RBBP4;CHD3;MTA1;HDAC1;SMC1A;RBBP7;STAG2;STAG1;HDAC2;BAZ1A;MBD2;SMC3	HR21 KIAA0078 NXP1 SCC1;SNF2H, WCRF135;MTA1L1 PID;None;RBAP48;None;None;RPD3L1;DXS423E KIAA0178 SB1.8 SMC1 SMC1L1;RBAP46;SA2;SA1 SCC3;None;ACF1, WCRF180;None;BAM BMH CSPG6 SMC3L1
283	SIN3 complex	Human	Histone deacetylase complex	HeLa cells; 293T cells	O00422;O75446;Q09028;Q13547;Q16576;Q92769;Q96ST3	10284;8819;5928;3065;5931;3066;25942	MI:0004-affinity chromatography technology;MI:0019-coimmunoprecipitation;MI:0047-far western blotting	GO:0006265;GO:0045892;GO:0006473;GO:0006476;GO:0051276	DNA topological change;negative regulation of DNA-templated transcription;protein acetylation;protein deacetylation;chromosome organization	10.01.09.05;11.02.03.04.03;14.07.04;42.10.03	DNA conformation modification (e.g. chromatin);transcription repression;modification by acetylation, deacetylation;organization of chromosome structure	9651585	None	None	The human SAP30 complex is active in deacetylating core histone octamers, but inactive in deacetylating nucleosomal histones due to the inability of the histone binding proteins RbAp46 and RbAp48 to gain access to nucleosomal histones.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone deacetylase complex subunit SAP18;Histone deacetylase complex subunit SAP30;Histone-binding protein RBBP4;Histone deacetylase 1;Histone-binding protein RBBP7;Histone deacetylase 2;Paired amphipathic helix protein Sin3a	SAP18;SAP30;RBBP4;HDAC1;RBBP7;HDAC2;SIN3A	None;None;RBAP48;RPD3L1;RBAP46;None;None
285	PCNA-MLH1-PMS1 complex	Human	None	None	P12004;P40692;P54277	5111;4292;5378	MI:0107-surface plasmon resonance	GO:0006260;GO:0006281;GO:0005634	DNA replication;DNA repair;nucleus	10.01.03;10.01.05.01;70.10	DNA synthesis and replication;DNA repair;nucleus	16303135	The authors show that PCNA interacts with MSH2-MSH6 with a higher affinity than with MLH1-PMS1. PCNA acts as a scaffold for consecutive protein-protein interactions.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Proliferating cell nuclear antigen;DNA mismatch repair protein Mlh1;PMS1 protein homolog 1	PCNA;MLH1;PMS1	None;COCA2;PMSL1
286	PCNA-MSH2-MSH6 complex	Human	None	None	P12004;P43246;P52701	5111;4436;2956	MI:0107-surface plasmon resonance	GO:0006260;GO:0006281;GO:0005634	DNA replication;DNA repair;nucleus	10.01.03;10.01.05.01;70.10	DNA synthesis and replication;DNA repair;nucleus	16303135	The authors show that PCNA interacts with MSH2-MSH6 with a higher affinity than with MLH1-PMS1.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Proliferating cell nuclear antigen;DNA mismatch repair protein Msh2;DNA mismatch repair protein Msh6	PCNA;MSH2;MSH6	None;None;GTBP
287	ARC-L complex	Human	None	None	O43513;O60244;O75448;O75586;P24863;P49336;Q13503;Q15648;Q71SY5;Q93074;Q96RN5;Q9NVC6;Q9UHV7;Q9ULK4	9443;9282;9862;10001;892;1024;9412;5469;81857;9968;51586;9440;9969;9439	MI:0004-affinity chromatography technology;MI:0029-cosedimentation through density gradient	GO:0005515;GO:0051090;GO:0005694	protein binding;regulation of DNA-binding transcription factor activity;chromosome	16.01;18.02.09;70.10.03	protein binding;regulator of transcription factor;chromosome	11834832	Experiemts show that the transcription coactivator ARC is required for SREBP (sterol regulatory element binding protein) control of cholesterol and lipid homeostasis. The activator-recruited cofactor ARC consists of the two distinct multisubunit complexes ARC-L and CRSP; Information about four small components of the protein complex is not available in the article. Several identical subunits appear in protein complexes like DRIP/ARC, CRSP, NAT, PC2, SMCC and Mediator, indicating that unique classes of transcription activators may share common sets or subsets of cofactors.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mediator of RNA polymerase II transcription subunit 7;Mediator of RNA polymerase II transcription subunit 14;Mediator of RNA polymerase II transcription subunit 24;Mediator of RNA polymerase II transcription subunit 6;Cyclin-C;Cyclin-dependent kinase 8;Mediator of RNA polymerase II transcription subunit 21;Mediator of RNA polymerase II transcription subunit 1;Mediator of RNA polymerase II transcription subunit 25;Mediator of RNA polymerase II transcription subunit 12;Mediator of RNA polymerase II transcription subunit 15;Mediator of RNA polymerase II transcription subunit 17;Mediator of RNA polymerase II transcription subunit 13;Mediator of RNA polymerase II transcription subunit 23	MED7;MED14;MED24;MED6;CCNC;CDK8;MED21;MED1;MED25;MED12;MED15;MED17;MED13;MED23	ARC34 CRSP9;ARC150 CRSP2 CXorf4 DRIP150 EXLM1 RGR1 TRAP170;ARC100 CRSP4 DRIP100 KIAA0130 THRAP4 TRAP100;ARC33;None;None;SRB7 SURB7;ARC205 CRSP1 CRSP200 DRIP205 DRIP230 PBP PPARBP PPARGBP RB18A TRAP220 TRIP2;ACID1 ARC92 PTOV2;ARC240 CAGH45 HOPA KIAA0192 TNRC11 TRAP230;ARC105 CTG7A PCQAP TIG1 TNRC7;ARC77 CRSP6 DRIP77 DRIP80 TRAP80;ARC250 KIAA0593 THRAP1 TRAP240;ARC130 CRSP3 DRIP130 KIAA1216 SUR2
290	MSH2-MLH1-PMS2-PCNA DNA-repair initiation complex	Human	None	HeLa cells	P12004;P40692;P43246;P54278	5111;4292;4436;5395	MI:0006-anti bait coimmunoprecipitation	GO:0006281;GO:0003677;GO:0006974;GO:0005634	DNA repair;DNA binding;cellular response to DNA damage stimulus;nucleus	10.01.05.01;16.03.01;32.01.09;70.10	DNA repair;DNA binding;DNA damage response;nucleus	9469823	Formation of the initiation complex is ATP-dependent.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Proliferating cell nuclear antigen;DNA mismatch repair protein Mlh1;DNA mismatch repair protein Msh2;Mismatch repair endonuclease PMS2	PCNA;MLH1;MSH2;PMS2	None;COCA2;None;PMSL2
291	MSH2-MLH1-PMS2 DNA-repair initiation complex	Human	None	HeLa cells	P40692;P43246;P54278	4292;4436;5395	MI:0006-anti bait coimmunoprecipitation	GO:0006281;GO:0003677;GO:0005634	DNA repair;DNA binding;nucleus	10.01.05.01;16.03.01;70.10	DNA repair;DNA binding;nucleus	9469823	Formation of the initiation complex is ATP-dependent.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA mismatch repair protein Mlh1;DNA mismatch repair protein Msh2;Mismatch repair endonuclease PMS2	MLH1;MSH2;PMS2	COCA2;None;PMSL2
297	PCNA-DNA polymerase delta complex	Human	None	HEK293 cells	P12004;P28340;P49005;Q15054;Q9HCU8	5111;5424;5425;10714;57804	MI:0006-anti bait coimmunoprecipitation;MI:0071-molecular sieving;MI:0096-pull down	GO:0006260;GO:0006281;GO:0005634	DNA replication;DNA repair;nucleus	10.01.03;10.01.05.01;70.10	DNA synthesis and replication;DNA repair;nucleus	11328591	PPLD3 stabilizes the polymerase delta complex and increases the affinity of polymerase delta for PCNA.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Proliferating cell nuclear antigen;DNA polymerase delta catalytic subunit;DNA polymerase delta subunit 2;DNA polymerase delta subunit 3;DNA polymerase delta subunit 4	PCNA;POLD1;POLD2;POLD3;POLD4	None;POLD;None;KIAA0039;POLDS
298	VEGF transcriptional complex	Human	None	PANC-1 cells ; PC-3 cells	P27695;P40763;Q16665;Q99966	328;6774;3091;4435	MI:0019-coimmunoprecipitation	GO:2001141;GO:0006355;GO:0005634	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;nucleus	11.02.03.04;70.10	transcriptional control;nucleus	15735682	None	This complex regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA-(apurinic or apyrimidinic site) endonuclease;Signal transducer and activator of transcription 3;Hypoxia-inducible factor 1-alpha;Cbp/p300-interacting transactivator 1	APEX1;STAT3;HIF1A;CITED1	APE APE1 APEX APX HAP1 REF1;APRF;BHLHE78 MOP1 PASD8;MSG1
299	CBP-IRF3 complex	Human	CREBBP-IRF3 complex	293T cells	Q14653;Q92793	3661;1387	MI:0019-coimmunoprecipitation;MI:0114-x-ray crystallography	GO:0006355	regulation of DNA-templated transcription	11.02.03.04	transcriptional control	16154084	The crystal structure of IRF-3 in complex with CBP reveals that CBP interacts with a hydrophobic surface on IRF-3, which in latent IRF-3 is covered by its autoinhibitory elements.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Interferon regulatory factor 3;CREB-binding protein	IRF3;CREBBP	None;CBP
300	PC2 complex	Human	None	None	O43513;O60244;O75448;O75586;Q13503;Q6P2C8;Q9BTT4;Q9H944;Q9NVC6;Q9Y2W1;Q9Y2X0;Q9Y3C7	9443;9282;9862;10001;9412;9442;84246;9477;9440;9967;10025;51003	MI:0071-molecular sieving;MI:0226-ion exchange chromatography	GO:0045893;GO:0005515;GO:0005634	positive regulation of DNA-templated transcription;protein binding;nucleus	11.02.03.04.01;16.01;70.10	transcription activation;protein binding;nucleus	10882111	According to the authors, PC2 is a submodule of TRAP/SMCC. Several identical subunits appear in protein complexes like DRIP/ARC, CRSP, NAT, PC2, SMCC and Mediator, indicating that unique classes of transcription activators may share common sets or subsets of cofactors.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mediator of RNA polymerase II transcription subunit 7;Mediator of RNA polymerase II transcription subunit 14;Mediator of RNA polymerase II transcription subunit 24;Mediator of RNA polymerase II transcription subunit 6;Mediator of RNA polymerase II transcription subunit 21;Mediator of RNA polymerase II transcription subunit 27;Mediator of RNA polymerase II transcription subunit 10;Mediator of RNA polymerase II transcription subunit 20;Mediator of RNA polymerase II transcription subunit 17;Thyroid hormone receptor-associated protein 3;Mediator of RNA polymerase II transcription subunit 16;Mediator of RNA polymerase II transcription subunit 31	MED7;MED14;MED24;MED6;MED21;MED27;MED10;MED20;MED17;THRAP3;MED16;MED31	ARC34 CRSP9;ARC150 CRSP2 CXorf4 DRIP150 EXLM1 RGR1 TRAP170;ARC100 CRSP4 DRIP100 KIAA0130 THRAP4 TRAP100;ARC33;SRB7 SURB7;CRSP34 CRSP8;None;TRFP;ARC77 CRSP6 DRIP77 DRIP80 TRAP80;BCLAF2 TRAP150;DRIP92 THRAP5;SOH1
301	SMCC complex	Human	SRB/MED-containing cofactor complex	None	O43513;O60244;O75448;O75586;P24863;P49336;Q13503;Q15648;Q6P2C8;Q93074;Q9BTT4;Q9H944;Q9NVC6;Q9UHV7;Q9Y2W1;Q9Y2X0;Q9Y3C7	9443;9282;9862;10001;892;1024;9412;5469;9442;9968;84246;9477;9440;9969;9967;10025;51003	MI:0007-anti tag coimmunoprecipitation	GO:2001141;GO:0006355;GO:0005515;GO:0005634	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;protein binding;nucleus	11.02.03.04;16.01;70.10	transcriptional control;protein binding;nucleus	10882111	Several identical subunits appear in protein complexes like DRIP/ARC, CRSP, NAT, PC2, SMCC and Mediator, indicating that unique classes of transcription activators may share common sets or subsets of cofactors.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mediator of RNA polymerase II transcription subunit 7;Mediator of RNA polymerase II transcription subunit 14;Mediator of RNA polymerase II transcription subunit 24;Mediator of RNA polymerase II transcription subunit 6;Cyclin-C;Cyclin-dependent kinase 8;Mediator of RNA polymerase II transcription subunit 21;Mediator of RNA polymerase II transcription subunit 1;Mediator of RNA polymerase II transcription subunit 27;Mediator of RNA polymerase II transcription subunit 12;Mediator of RNA polymerase II transcription subunit 10;Mediator of RNA polymerase II transcription subunit 20;Mediator of RNA polymerase II transcription subunit 17;Mediator of RNA polymerase II transcription subunit 13;Thyroid hormone receptor-associated protein 3;Mediator of RNA polymerase II transcription subunit 16;Mediator of RNA polymerase II transcription subunit 31	MED7;MED14;MED24;MED6;CCNC;CDK8;MED21;MED1;MED27;MED12;MED10;MED20;MED17;MED13;THRAP3;MED16;MED31	ARC34 CRSP9;ARC150 CRSP2 CXorf4 DRIP150 EXLM1 RGR1 TRAP170;ARC100 CRSP4 DRIP100 KIAA0130 THRAP4 TRAP100;ARC33;None;None;SRB7 SURB7;ARC205 CRSP1 CRSP200 DRIP205 DRIP230 PBP PPARBP PPARGBP RB18A TRAP220 TRIP2;CRSP34 CRSP8;ARC240 CAGH45 HOPA KIAA0192 TNRC11 TRAP230;None;TRFP;ARC77 CRSP6 DRIP77 DRIP80 TRAP80;ARC250 KIAA0593 THRAP1 TRAP240;BCLAF2 TRAP150;DRIP92 THRAP5;SOH1
302	INO80 chromatin remodeling complex	Human	INO80 complex	None	O96019;P15923;Q53TQ3;Q6P4R8;Q6PI98;Q8NBZ0;Q96EZ8;Q9C086;Q9H981;Q9H9F9;Q9ULG1;Q9Y230;Q9Y265	86;6929;54891;4798;125476;283899;10445;83444;93973;79913;54617;10856;8607	MI:0007-anti tag coimmunoprecipitation	GO:0006265;GO:0003677;GO:0005524;GO:0051276;GO:0005694	DNA topological change;DNA binding;ATP binding;chromosome organization;chromosome	10.01.09.05;16.03.01;16.19.03;42.10.03;70.10.03	DNA conformation modification (e.g. chromatin);DNA binding;ATP binding;organization of chromosome structure;chromosome	16230350	INO80 complex exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Actin-like protein 6A;Transcription factor E2-alpha;INO80 complex subunit D;Nuclear factor related to kappa-B-binding protein;INO80 complex subunit C;INO80 complex subunit E;Microspherule protein 1;INO80 complex subunit B;Actin-related protein 8;Actin-related protein 5;Chromatin-remodeling ATPase INO80;RuvB-like 2;RuvB-like 1	ACTL6A;TCF3;INO80D;NFRKB;INO80C;INO80E;MCRS1;INO80B;ACTR8;ACTR5;INO80;RUVBL2;RUVBL1	BAF53 BAF53A INO80K;BHLHB21 E2A ITF1;;INO80G;C18orf37;CCDC95;INO80Q MSP58;HMGA1L4 PAPA1 ZNHIT4;ARP8 INO80N;ARP5;INO80A INOC1 KIAA1259;INO80J TIP48 TIP49B;INO80H NMP238 TIP49 TIP49A
304	SRCAP complex	Human	SRCAP-associated chromatin remodeling complex	HEK293 cells	O43257;O95619;O96019;P0C0S5;Q15906;Q6ZRS2;Q96CJ1;Q9GZN1;Q9Y230;Q9Y265	10467;8089;86;3015;6944;10847;55840;64431;10856;8607	MI:0007-anti tag coimmunoprecipitation	GO:0006338;GO:0005634	chromatin remodeling;nucleus	70.10	nucleus	15647280	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Zinc finger HIT domain-containing protein 1;YEATS domain-containing protein 4;Actin-like protein 6A;Histone H2A.Z;Vacuolar protein sorting-associated protein 72 homolog;Helicase SRCAP;ELL-associated factor 2;Actin-related protein 6;RuvB-like 2;RuvB-like 1	ZNHIT1;YEATS4;ACTL6A;H2AZ1;VPS72;SRCAP;EAF2;ACTR6;RUVBL2;RUVBL1	CGBP1 ZNFN4A1;GAS41;BAF53 BAF53A INO80K;H2AFZ H2AZ;TCFL1 YL1;KIAA0309;TRAITS;None;INO80J TIP48 TIP49B;INO80H NMP238 TIP49 TIP49A
305	40S ribosomal subunit, cytoplasmic	Human	small ribosomal subunit, cytoplasmic	None	P08708;P08865;P15880;P22090;P23396;P25398;P39019;P42677;P46781;P46782;P46783;P60866;P61247;P62081;P62241;P62244;P62249;P62263;P62266;P62269;P62273;P62277;P62280;P62701;P62753;P62841;P62847;P62851;P62854;P62857;P62861;P62979;P63220	6218;3921;6187;6192;6188;6206;6223;6232;6203;6193;6204;6224;6189;6201;6202;6210;6217;6208;6228;6222;6235;6207;6205;6191;6194;6209;6229;6230;6231;6234;2197;6233;6227	MI:0363-inferred by author	GO:0006412;GO:0005737	translation;cytoplasm	12.04;70.03	translation;cytoplasm	14681386	None	None	Since the authors did not specify RPS4Y, we used isoform RPS4Y1	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	40S ribosomal protein S17;40S ribosomal protein SA;40S ribosomal protein S2;40S ribosomal protein S4, Y isoform 1;40S ribosomal protein S3;40S ribosomal protein S12;40S ribosomal protein S19;40S ribosomal protein S27;40S ribosomal protein S9;40S ribosomal protein S5;40S ribosomal protein S10;40S ribosomal protein S20;40S ribosomal protein S3a;40S ribosomal protein S7;40S ribosomal protein S8;40S ribosomal protein S15a;40S ribosomal protein S16;40S ribosomal protein S14;40S ribosomal protein S23;40S ribosomal protein S18;40S ribosomal protein S29;40S ribosomal protein S13;40S ribosomal protein S11;40S ribosomal protein S4, X isoform;40S ribosomal protein S6;40S ribosomal protein S15;40S ribosomal protein S24;40S ribosomal protein S25;40S ribosomal protein S26;40S ribosomal protein S28;FAU ubiquitin-like and ribosomal protein S30;Ubiquitin-40S ribosomal protein S27a;40S ribosomal protein S21	RPS17;RPSA;RPS2;RPS4Y1;RPS3;RPS12;RPS19;RPS27;RPS9;RPS5;RPS10;RPS20;RPS3A;RPS7;RPS8;RPS15A;RPS16;RPS14;RPS23;RPS18;RPS29;RPS13;RPS11;RPS4X;RPS6;RPS15;RPS24;RPS25;RPS26;RPS28;FAU;RPS27A;RPS21	RPS17L;LAMBR LAMR1;RPS4;RPS4Y;None;None;None;MPS1;None;None;None;None;FTE1 MFTL;None;None;None;None;None;None;D6S218E;None;None;None;CCG2 RPS4 SCAR;None;RIG;None;None;None;None;None;UBA80 UBCEP1;None
306	Ribosome, cytoplasmic	Human	None	None	P05386;P05387;P05388;P08708;P08865;P15880;P18077;P18124;P18621;P22090;P23396;P25398;P26373;P27635;P30050;P32969;P35268;P36578;P39019;P39023;P40429;P42677;P42766;P46776;P46777;P46778;P46779;P46781;P46782;P46783;P47914;P49207;P50914;P60866;P61247;P61254;P61313;P61353;P61513;P61927;P62081;P62241;P62244;P62249;P62263;P62266;P62269;P62273;P62277;P62280;P62424;P62701;P62750;P62753;P62829;P62841;P62847;P62851;P62854;P62857;P62861;P62888;P62891;P62899;P62906;P62910;P62913;P62917;P62945;P62979;P62987;P63173;P63220;P83731;P83881;P84098;Q02543;Q02878;Q07020;Q9Y3U8	6176;6181;6175;6218;3921;6187;6165;6129;6139;6192;6188;6206;6137;6134;6136;6133;6146;6124;6223;6122;23521;6232;11224;6157;6125;6144;6158;6203;6193;6204;6159;6164;9045;6224;6189;6154;6138;6155;6168;6167;6201;6202;6210;6217;6208;6228;6222;6235;6207;6205;6130;6191;6147;6194;9349;6209;6229;6230;6231;6234;2197;6156;6170;6160;4736;6161;6135;6132;6171;6233;7311;6169;6227;6152;6173;6143;6142;6128;6141;25873	MI:0363-inferred by author	GO:0006412;GO:0005737	translation;cytoplasm	12.04;70.03	translation;cytoplasm	14681386	None	None	Since the authors did not specify RPS4Y, we used isoform RPS4Y1	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	60S acidic ribosomal protein P1;60S acidic ribosomal protein P2;60S acidic ribosomal protein P0;40S ribosomal protein S17;40S ribosomal protein SA;40S ribosomal protein S2;60S ribosomal protein L35a;60S ribosomal protein L7;60S ribosomal protein L17;40S ribosomal protein S4, Y isoform 1;40S ribosomal protein S3;40S ribosomal protein S12;60S ribosomal protein L13;60S ribosomal protein L10;60S ribosomal protein L12;60S ribosomal protein L9;60S ribosomal protein L22;60S ribosomal protein L4;40S ribosomal protein S19;60S ribosomal protein L3;60S ribosomal protein L13a;40S ribosomal protein S27;60S ribosomal protein L35;60S ribosomal protein L27a;60S ribosomal protein L5;60S ribosomal protein L21;60S ribosomal protein L28;40S ribosomal protein S9;40S ribosomal protein S5;40S ribosomal protein S10;60S ribosomal protein L29;60S ribosomal protein L34;60S ribosomal protein L14;40S ribosomal protein S20;40S ribosomal protein S3a;60S ribosomal protein L26;60S ribosomal protein L15;60S ribosomal protein L27;60S ribosomal protein L37a;60S ribosomal protein L37;40S ribosomal protein S7;40S ribosomal protein S8;40S ribosomal protein S15a;40S ribosomal protein S16;40S ribosomal protein S14;40S ribosomal protein S23;40S ribosomal protein S18;40S ribosomal protein S29;40S ribosomal protein S13;40S ribosomal protein S11;60S ribosomal protein L7a;40S ribosomal protein S4, X isoform;60S ribosomal protein L23a;40S ribosomal protein S6;60S ribosomal protein L23;40S ribosomal protein S15;40S ribosomal protein S24;40S ribosomal protein S25;40S ribosomal protein S26;40S ribosomal protein S28;FAU ubiquitin-like and ribosomal protein S30;60S ribosomal protein L30;60S ribosomal protein L39;60S ribosomal protein L31;60S ribosomal protein L10a;60S ribosomal protein L32;60S ribosomal protein L11;60S ribosomal protein L8;60S ribosomal protein L41;Ubiquitin-40S ribosomal protein S27a;Ubiquitin-60S ribosomal protein L40;60S ribosomal protein L38;40S ribosomal protein S21;60S ribosomal protein L24;60S ribosomal protein L36a;60S ribosomal protein L19;60S ribosomal protein L18a;60S ribosomal protein L6;60S ribosomal protein L18;60S ribosomal protein L36	RPLP1;RPLP2;RPLP0;RPS17;RPSA;RPS2;RPL35A;RPL7;RPL17;RPS4Y1;RPS3;RPS12;RPL13;RPL10;RPL12;RPL9;RPL22;RPL4;RPS19;RPL3;RPL13A;RPS27;RPL35;RPL27A;RPL5;RPL21;RPL28;RPS9;RPS5;RPS10;RPL29;RPL34;RPL14;RPS20;RPS3A;RPL26;RPL15;RPL27;RPL37A;RPL37;RPS7;RPS8;RPS15A;RPS16;RPS14;RPS23;RPS18;RPS29;RPS13;RPS11;RPL7A;RPS4X;RPL23A;RPS6;RPL23;RPS15;RPS24;RPS25;RPS26;RPS28;FAU;RPL30;RPL39;RPL31;RPL10A;RPL32;RPL11;RPL8;RPL41;RPS27A;UBA52;RPL38;RPS21;RPL24;RPL36A;RPL19;RPL18A;RPL6;RPL18;RPL36	RRP1;D11S2243E RPP2;None;RPS17L;LAMBR LAMR1;RPS4;None;None;None;RPS4Y;None;None;BBC1;DXS648E QM;None;None;None;RPL1;None;None;None;MPS1;None;None;None;None;None;None;None;None;None;None;None;None;FTE1 MFTL;None;EC45;None;None;None;None;None;None;None;None;None;D6S218E;None;None;None;SURF-3 SURF3;CCG2 RPS4 SCAR;None;None;None;RIG;None;None;None;None;None;None;None;None;NEDD6;None;None;None;None;UBA80 UBCEP1;UBCEP2;None;None;None;RPL44;None;None;TXREB1;None;None
308	60S ribosomal subunit, cytoplasmic	Human	large ribosomal subunit, cytoplasmic	None	P05386;P05387;P05388;P18077;P18124;P18621;P26373;P27635;P30050;P32969;P35268;P36578;P39023;P40429;P42766;P46776;P46777;P46778;P46779;P47914;P49207;P50914;P61254;P61313;P61353;P61513;P61927;P62424;P62750;P62829;P62888;P62891;P62899;P62906;P62910;P62913;P62917;P62945;P62987;P63173;P83731;P83881;P84098;Q02543;Q02878;Q07020;Q9Y3U8	6176;6181;6175;6165;6129;6139;6137;6134;6136;6133;6146;6124;6122;23521;11224;6157;6125;6144;6158;6159;6164;9045;6154;6138;6155;6168;6167;6130;6147;9349;6156;6170;6160;4736;6161;6135;6132;6171;7311;6169;6152;6173;6143;6142;6128;6141;25873	MI:0363-inferred by author	GO:0006412;GO:0005737	translation;cytoplasm	12.04;70.03	translation;cytoplasm	14681386	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	60S acidic ribosomal protein P1;60S acidic ribosomal protein P2;60S acidic ribosomal protein P0;60S ribosomal protein L35a;60S ribosomal protein L7;60S ribosomal protein L17;60S ribosomal protein L13;60S ribosomal protein L10;60S ribosomal protein L12;60S ribosomal protein L9;60S ribosomal protein L22;60S ribosomal protein L4;60S ribosomal protein L3;60S ribosomal protein L13a;60S ribosomal protein L35;60S ribosomal protein L27a;60S ribosomal protein L5;60S ribosomal protein L21;60S ribosomal protein L28;60S ribosomal protein L29;60S ribosomal protein L34;60S ribosomal protein L14;60S ribosomal protein L26;60S ribosomal protein L15;60S ribosomal protein L27;60S ribosomal protein L37a;60S ribosomal protein L37;60S ribosomal protein L7a;60S ribosomal protein L23a;60S ribosomal protein L23;60S ribosomal protein L30;60S ribosomal protein L39;60S ribosomal protein L31;60S ribosomal protein L10a;60S ribosomal protein L32;60S ribosomal protein L11;60S ribosomal protein L8;60S ribosomal protein L41;Ubiquitin-60S ribosomal protein L40;60S ribosomal protein L38;60S ribosomal protein L24;60S ribosomal protein L36a;60S ribosomal protein L19;60S ribosomal protein L18a;60S ribosomal protein L6;60S ribosomal protein L18;60S ribosomal protein L36	RPLP1;RPLP2;RPLP0;RPL35A;RPL7;RPL17;RPL13;RPL10;RPL12;RPL9;RPL22;RPL4;RPL3;RPL13A;RPL35;RPL27A;RPL5;RPL21;RPL28;RPL29;RPL34;RPL14;RPL26;RPL15;RPL27;RPL37A;RPL37;RPL7A;RPL23A;RPL23;RPL30;RPL39;RPL31;RPL10A;RPL32;RPL11;RPL8;RPL41;UBA52;RPL38;RPL24;RPL36A;RPL19;RPL18A;RPL6;RPL18;RPL36	RRP1;D11S2243E RPP2;None;None;None;None;BBC1;DXS648E QM;None;None;None;RPL1;None;None;None;None;None;None;None;None;None;None;None;EC45;None;None;None;SURF-3 SURF3;None;None;None;None;None;NEDD6;None;None;None;None;UBCEP2;None;None;RPL44;None;None;TXREB1;None;None
310	Cell cycle kinase complex CDC2	Human	None	HeLa cells	O95067;P06493;P12004;P14635;P24385;P38936	9133;983;5111;891;595;1026	MI:0006-anti bait coimmunoprecipitation	GO:0000278	mitotic cell cycle	10.03.01.01	mitotic cell cycle	7903056	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	G2/mitotic-specific cyclin-B2;Cyclin-dependent kinase 1;Proliferating cell nuclear antigen;G2/mitotic-specific cyclin-B1;G1/S-specific cyclin-D1;Cyclin-dependent kinase inhibitor 1	CCNB2;CDK1;PCNA;CCNB1;CCND1;CDKN1A	None;CDC2 CDC28A CDKN1 P34CDC2;None;CCNB;BCL1 PRAD1;CAP20 CDKN1 CIP1 MDA6 PIC1 SDI1 WAF1
311	Cell cycle kinase complex CDK2	Human	None	HeLa cells	P12004;P24385;P24941;P38936	5111;595;1017;1026	MI:0006-anti bait coimmunoprecipitation	GO:0000278	mitotic cell cycle	10.03.01.01	mitotic cell cycle	7903056	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Proliferating cell nuclear antigen;G1/S-specific cyclin-D1;Cyclin-dependent kinase 2;Cyclin-dependent kinase inhibitor 1	PCNA;CCND1;CDK2;CDKN1A	None;BCL1 PRAD1;CDKN2;CAP20 CDKN1 CIP1 MDA6 PIC1 SDI1 WAF1
312	Cell cycle kinase complex CDK4	Human	None	HeLa cells	P11802;P12004;P24385;P38936	1019;5111;595;1026	MI:0006-anti bait coimmunoprecipitation	GO:0000278	mitotic cell cycle	10.03.01.01	mitotic cell cycle	7903056	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cyclin-dependent kinase 4;Proliferating cell nuclear antigen;G1/S-specific cyclin-D1;Cyclin-dependent kinase inhibitor 1	CDK4;PCNA;CCND1;CDKN1A	None;None;BCL1 PRAD1;CAP20 CDKN1 CIP1 MDA6 PIC1 SDI1 WAF1
313	Cell cycle kinase complex CDK5	Human	None	HeLa cells	P12004;P24385;P30281;P38936;Q00535	5111;595;896;1026;1020	MI:0006-anti bait coimmunoprecipitation	GO:0000278;GO:0006468	mitotic cell cycle;protein phosphorylation	10.03.01.01;14.07.03	mitotic cell cycle;modification by phosphorylation, dephosphorylation, autophosphorylation	7903056	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Proliferating cell nuclear antigen;G1/S-specific cyclin-D1;G1/S-specific cyclin-D3;Cyclin-dependent kinase inhibitor 1;Cyclin-dependent kinase 5	PCNA;CCND1;CCND3;CDKN1A;CDK5	None;BCL1 PRAD1;None;CAP20 CDKN1 CIP1 MDA6 PIC1 SDI1 WAF1;CDKN5 PSSALRE
314	PCNA-p21 complex	Human	None	None	P12004;P38936	5111;1026	MI:0114-x-ray crystallography	GO:0000075;GO:0005634	cell cycle checkpoint signaling;nucleus	10.03.01.03;70.10	cell cycle checkpoints (checkpoints of morphogenesis, DNA-damage,-replication, mitotic phase and spindle);nucleus	8861913	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Proliferating cell nuclear antigen;Cyclin-dependent kinase inhibitor 1	PCNA;CDKN1A	None;CAP20 CDKN1 CIP1 MDA6 PIC1 SDI1 WAF1
315	28S ribosomal subunit, mitochondrial	Human	Small ribosomal subunit, mitochondrial	None	O15235;O60783;P51398;P82650;P82663;P82664;P82673;P82675;P82909;P82912;P82914;P82921;P82930;P82932;P82933;Q92552;Q92665;Q96EL2;Q9BYN8;Q9NP92;Q9NVS2;Q9Y291;Q9Y2Q9;Q9Y2R5;Q9Y2R9;Q9Y399;Q9Y3D3;Q9Y3D5;Q9Y3D9;Q9Y676	6183;63931;7818;56945;64432;55173;None;64969;92259;64963;64960;54460;65993;64968;64965;23107;10240;64951;64949;10884;55168;51650;28957;51373;51081;51116;51021;51023;51649;28973	MI:0363-inferred by author	GO:0006412;GO:0005759	translation;mitochondrial matrix	12.04;70.16.07	translation;mitochondrial matrix	14681386	With the exception of MRPS12, all proteins of the small ribosomal subunit from ribosomes of Bos taurus were identified in a proteomic approach (PMID:11279123).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	28S ribosomal protein S12, mitochondrial;28S ribosomal protein S14, mitochondrial;28S ribosomal protein S29, mitochondrial;28S ribosomal protein S22, mitochondrial;28S ribosomal protein S25, mitochondrial;28S ribosomal protein S10, mitochondrial;28S ribosomal protein S35, mitochondrial;28S ribosomal protein S5, mitochondrial;Alpha-ketoglutarate dehydrogenase component 4;28S ribosomal protein S11, mitochondrial;28S ribosomal protein S15, mitochondrial;28S ribosomal protein S21, mitochondrial;28S ribosomal protein S34, mitochondrial;28S ribosomal protein S6, mitochondrial;28S ribosomal protein S9, mitochondrial;28S ribosomal protein S27, mitochondrial;28S ribosomal protein S31, mitochondrial;28S ribosomal protein S24, mitochondrial;28S ribosomal protein S26, mitochondrial;39S ribosomal protein S30, mitochondrial;39S ribosomal protein S18a, mitochondrial;28S ribosomal protein S33, mitochondrial;28S ribosomal protein S28, mitochondrial;28S ribosomal protein S17, mitochondrial;28S ribosomal protein S7, mitochondrial;28S ribosomal protein S2, mitochondrial;28S ribosomal protein S16, mitochondrial;28S ribosomal protein S18c, mitochondrial;28S ribosomal protein S23, mitochondrial;28S ribosomal protein S18b, mitochondrial	MRPS12;MRPS14;DAP3;MRPS22;MRPS25;MRPS10;MRPS35;MRPS5;MRPS36;MRPS11;MRPS15;MRPS21;MRPS34;MRPS6;MRPS9;MRPS27;MRPS31;MRPS24;MRPS26;MRPS30;MRPS18A;MRPS33;MRPS28;MRPS17;MRPS7;MRPS2;MRPS16;MRPS18C;MRPS23;MRPS18B	RPMS12 RPSM12;None;MRPS29;C3orf5 RPMS22;RPMS25;None;MRPS28;None;KGD4;RPMS11;RPMS15;RPMS21;None;C21orf101 RPMS6;RPMS9;KIAA0264;IMOGN38;None;C20orf193 RPMS13;PDCD9;None;None;MRPS35;RPMS17;None;None;RPMS16;None;None;C6orf14
320	55S ribosome, mitochondrial	Human	None	None	O15235;O60783;O75394;P09001;P49406;P51398;P52815;P82650;P82663;P82664;P82673;P82675;P82909;P82912;P82914;P82921;P82930;P82932;P82933;P83111;Q13084;Q13405;Q16540;Q4U2R6;Q5T653;Q6P161;Q6P1L8;Q7Z2W9;Q7Z7F7;Q7Z7H8;Q86TS9;Q8IXM3;Q8N5N7;Q8N983;Q8TCC3;Q92552;Q92665;Q96A35;Q96DV4;Q96EL2;Q96EL3;Q96GC5;Q9BQ48;Q9BRJ2;Q9BYC8;Q9BYC9;Q9BYD1;Q9BYD2;Q9BYD3;Q9BYD6;Q9BYN8;Q9BZE1;Q9H0U6;Q9H2W6;Q9H9J2;Q9HD33;Q9NP92;Q9NQ50;Q9NRX2;Q9NVS2;Q9NWU5;Q9NX20;Q9NYK5;Q9NZE8;Q9P015;Q9P0J6;Q9P0M9;Q9Y291;Q9Y2Q9;Q9Y2R5;Q9Y2R9;Q9Y399;Q9Y3B7;Q9Y3D3;Q9Y3D5;Q9Y3D9;Q9Y676;Q9Y6G3	6183;63931;9553;11222;9801;7818;6182;56945;64432;55173;None;64969;92259;64963;64960;54460;65993;64968;64965;114294;10573;740;6150;51258;51069;116541;64928;219927;128308;124995;122704;64975;54534;84545;51263;23107;10240;79590;64978;64951;116540;51642;64981;84311;64983;55052;28998;65005;51073;65008;64949;51253;29074;26589;65080;57129;10884;64976;63875;55168;29093;54948;54148;51318;29088;64979;51264;51650;28957;51373;51081;51116;65003;51021;51023;51649;28973;28977	MI:0363-inferred by author	GO:0006412;GO:0005759	translation;mitochondrial matrix	12.04;70.16.07	translation;mitochondrial matrix	14681386	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	28S ribosomal protein S12, mitochondrial;28S ribosomal protein S14, mitochondrial;39S ribosomal protein L33, mitochondrial;39S ribosomal protein L3, mitochondrial;39S ribosomal protein L19, mitochondrial;28S ribosomal protein S29, mitochondrial;39S ribosomal protein L12, mitochondrial;28S ribosomal protein S22, mitochondrial;28S ribosomal protein S25, mitochondrial;28S ribosomal protein S10, mitochondrial;28S ribosomal protein S35, mitochondrial;28S ribosomal protein S5, mitochondrial;Alpha-ketoglutarate dehydrogenase component 4;28S ribosomal protein S11, mitochondrial;28S ribosomal protein S15, mitochondrial;28S ribosomal protein S21, mitochondrial;28S ribosomal protein S34, mitochondrial;28S ribosomal protein S6, mitochondrial;28S ribosomal protein S9, mitochondrial;Serine beta-lactamase-like protein LACTB, mitochondrial;39S ribosomal protein L28, mitochondrial;39S ribosomal protein L49, mitochondrial;39S ribosomal protein L23, mitochondrial;39S ribosomal protein L51, mitochondrial;39S ribosomal protein L2, mitochondrial;39S ribosomal protein L54, mitochondrial;39S ribosomal protein L14, mitochondrial;39S ribosomal protein L21, mitochondrial;39S ribosomal protein L55, mitochondrial;39S ribosomal protein L10, mitochondrial;39S ribosomal protein L52, mitochondrial;39S ribosomal protein L41, mitochondrial;39S ribosomal protein L50, mitochondrial;39S ribosomal protein L43, mitochondrial;39S ribosomal protein L30, mitochondrial;28S ribosomal protein S27, mitochondrial;28S ribosomal protein S31, mitochondrial;39S ribosomal protein L24, mitochondrial;39S ribosomal protein L38, mitochondrial;28S ribosomal protein S24, mitochondrial;39S ribosomal protein L53, mitochondrial;39S ribosomal protein L48, mitochondrial;39S ribosomal protein L34, mitochondrial;39S ribosomal protein L45, mitochondrial;39S ribosomal protein L32, mitochondrial;39S ribosomal protein L20, mitochondrial;39S ribosomal protein L13, mitochondrial;39S ribosomal protein L9, mitochondrial;39S ribosomal protein L4, mitochondrial;39S ribosomal protein L1, mitochondrial;28S ribosomal protein S26, mitochondrial;39S ribosomal protein L37, mitochondrial;39S ribosomal protein L18, mitochondrial;39S ribosomal protein L46, mitochondrial;39S ribosomal protein L44, mitochondrial;39S ribosomal protein L47, mitochondrial;39S ribosomal protein S30, mitochondrial;39S ribosomal protein L40, mitochondrial;39S ribosomal protein L17, mitochondrial;39S ribosomal protein S18a, mitochondrial;39S ribosomal protein L22, mitochondrial;39S ribosomal protein L16, mitochondrial;39S ribosomal protein L39, mitochondrial;39S ribosomal protein L35, mitochondrial;39S ribosomal protein L15, mitochondrial;39S ribosomal protein L36, mitochondrial;39S ribosomal protein L27, mitochondrial;28S ribosomal protein S33, mitochondrial;28S ribosomal protein S28, mitochondrial;28S ribosomal protein S17, mitochondrial;28S ribosomal protein S7, mitochondrial;28S ribosomal protein S2, mitochondrial;39S ribosomal protein L11, mitochondrial;28S ribosomal protein S16, mitochondrial;28S ribosomal protein S18c, mitochondrial;28S ribosomal protein S23, mitochondrial;28S ribosomal protein S18b, mitochondrial;39S ribosomal protein L42, mitochondrial	MRPS12;MRPS14;MRPL33;MRPL3;MRPL19;DAP3;MRPL12;MRPS22;MRPS25;MRPS10;MRPS35;MRPS5;MRPS36;MRPS11;MRPS15;MRPS21;MRPS34;MRPS6;MRPS9;LACTB;MRPL28;MRPL49;MRPL23;MRPL51;MRPL2;MRPL54;MRPL14;MRPL21;MRPL55;MRPL10;MRPL52;MRPL41;MRPL50;MRPL43;MRPL30;MRPS27;MRPS31;MRPL24;MRPL38;MRPS24;MRPL53;MRPL48;MRPL34;MRPL45;MRPL32;MRPL20;MRPL13;MRPL9;MRPL4;MRPL1;MRPS26;MRPL37;MRPL18;MRPL46;MRPL44;MRPL47;MRPS30;MRPL40;MRPL17;MRPS18A;MRPL22;MRPL16;MRPL39;MRPL35;MRPL15;MRPL36;MRPL27;MRPS33;MRPS28;MRPS17;MRPS7;MRPS2;MRPL11;MRPS16;MRPS18C;MRPS23;MRPS18B;MRPL42	RPMS12 RPSM12;None;C2orf1;MRL3 RPML3;KIAA0104 MRPL15;MRPS29;MRPL7 RPML12;C3orf5 RPMS22;RPMS25;None;MRPS28;None;KGD4;RPMS11;RPMS15;RPMS21;None;C21orf101 RPMS6;RPMS9;MRPL56;MAAT1;C11orf4 NOF1;L23MRP RPL23L;MRP64;None;None;MRPL32 RPML32;None;None;MRPL8 RPML8;None;BMRP MRPL27 RPML27;None;None;MRPL28 RPML28;KIAA0264;IMOGN38;None;None;None;None;None;None;None;None;None;None;None;None;None;C20orf193 RPMS13;MRPL2 RPML2;None;C15orf4 LIECG2;None;NCM1;PDCD9;NLVCF URIM;LIP2;None;MRPL25 RPML25;None;C21orf92 MRPL5 RPML5;None;None;BRIP1;None;None;MRPS35;RPMS17;None;None;None;RPMS16;None;None;C6orf14;MRPL31 MRPS32 RPML31
322	DNA-PK-Ku complex	Human	DNA-PK-Ku antigen complex; DNA-PK-Ku70-Ku80 complex	HeLa cells	P12956;P13010;P78527	2547;7520;5591	MI:0029-cosedimentation through density gradient;MI:0040-electron microscopy	GO:0006468;GO:0046777;GO:0003677;GO:0005634;GO:0006303	protein phosphorylation;protein autophosphorylation;DNA binding;nucleus;double-strand break repair via nonhomologous end joining	14.07.03;16.03.01;70.10	modification by phosphorylation, dephosphorylation, autophosphorylation;DNA binding;nucleus	16713581	For assembly of the DNA-PK-Ku70-Ku80 complex presence of DNA is necessary. DNA-bound Ku directs the recruitment of the catalytic subunit DNA-Pk via a small helical domain at the C-terminus of Ku80. (PMID: 16713581)	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	X-ray repair cross-complementing protein 6;X-ray repair cross-complementing protein 5;DNA-dependent protein kinase catalytic subunit	XRCC6;XRCC5;PRKDC	G22P1;G22P2;HYRC HYRC1
324	39S ribosomal subunit, mitochondrial	Human	Large ribosomal subunit, mitochondrial	None	O75394;P09001;P49406;P52815;P83111;Q13084;Q13405;Q16540;Q4U2R6;Q5T653;Q6P161;Q6P1L8;Q7Z2W9;Q7Z7F7;Q7Z7H8;Q86TS9;Q8IXM3;Q8N5N7;Q8N983;Q8TCC3;Q96A35;Q96DV4;Q96EL3;Q96GC5;Q9BQ48;Q9BRJ2;Q9BYC8;Q9BYC9;Q9BYD1;Q9BYD2;Q9BYD3;Q9BYD6;Q9BZE1;Q9H0U6;Q9H2W6;Q9H9J2;Q9HD33;Q9NQ50;Q9NRX2;Q9NWU5;Q9NX20;Q9NYK5;Q9NZE8;Q9P015;Q9P0J6;Q9P0M9;Q9Y3B7;Q9Y6G3	9553;11222;9801;6182;114294;10573;740;6150;51258;51069;116541;64928;219927;128308;124995;122704;64975;54534;84545;51263;79590;64978;116540;51642;64981;84311;64983;55052;28998;65005;51073;65008;51253;29074;26589;65080;57129;64976;63875;29093;54948;54148;51318;29088;64979;51264;65003;28977	MI:0363-inferred by author	GO:0006412;GO:0005759	translation;mitochondrial matrix	12.04;70.16.07	translation;mitochondrial matrix	14681386	With the exception of MRPL36 and MRPL42, all proteins of the large ribosomal subunit from ribosomes of Bos taurus were identified in a proteomic approach (PMID:11551941).	None	At the time of annotation, about half of the bovine subunits were not found in the UniProt database.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	39S ribosomal protein L33, mitochondrial;39S ribosomal protein L3, mitochondrial;39S ribosomal protein L19, mitochondrial;39S ribosomal protein L12, mitochondrial;Serine beta-lactamase-like protein LACTB, mitochondrial;39S ribosomal protein L28, mitochondrial;39S ribosomal protein L49, mitochondrial;39S ribosomal protein L23, mitochondrial;39S ribosomal protein L51, mitochondrial;39S ribosomal protein L2, mitochondrial;39S ribosomal protein L54, mitochondrial;39S ribosomal protein L14, mitochondrial;39S ribosomal protein L21, mitochondrial;39S ribosomal protein L55, mitochondrial;39S ribosomal protein L10, mitochondrial;39S ribosomal protein L52, mitochondrial;39S ribosomal protein L41, mitochondrial;39S ribosomal protein L50, mitochondrial;39S ribosomal protein L43, mitochondrial;39S ribosomal protein L30, mitochondrial;39S ribosomal protein L24, mitochondrial;39S ribosomal protein L38, mitochondrial;39S ribosomal protein L53, mitochondrial;39S ribosomal protein L48, mitochondrial;39S ribosomal protein L34, mitochondrial;39S ribosomal protein L45, mitochondrial;39S ribosomal protein L32, mitochondrial;39S ribosomal protein L20, mitochondrial;39S ribosomal protein L13, mitochondrial;39S ribosomal protein L9, mitochondrial;39S ribosomal protein L4, mitochondrial;39S ribosomal protein L1, mitochondrial;39S ribosomal protein L37, mitochondrial;39S ribosomal protein L18, mitochondrial;39S ribosomal protein L46, mitochondrial;39S ribosomal protein L44, mitochondrial;39S ribosomal protein L47, mitochondrial;39S ribosomal protein L40, mitochondrial;39S ribosomal protein L17, mitochondrial;39S ribosomal protein L22, mitochondrial;39S ribosomal protein L16, mitochondrial;39S ribosomal protein L39, mitochondrial;39S ribosomal protein L35, mitochondrial;39S ribosomal protein L15, mitochondrial;39S ribosomal protein L36, mitochondrial;39S ribosomal protein L27, mitochondrial;39S ribosomal protein L11, mitochondrial;39S ribosomal protein L42, mitochondrial	MRPL33;MRPL3;MRPL19;MRPL12;LACTB;MRPL28;MRPL49;MRPL23;MRPL51;MRPL2;MRPL54;MRPL14;MRPL21;MRPL55;MRPL10;MRPL52;MRPL41;MRPL50;MRPL43;MRPL30;MRPL24;MRPL38;MRPL53;MRPL48;MRPL34;MRPL45;MRPL32;MRPL20;MRPL13;MRPL9;MRPL4;MRPL1;MRPL37;MRPL18;MRPL46;MRPL44;MRPL47;MRPL40;MRPL17;MRPL22;MRPL16;MRPL39;MRPL35;MRPL15;MRPL36;MRPL27;MRPL11;MRPL42	C2orf1;MRL3 RPML3;KIAA0104 MRPL15;MRPL7 RPML12;MRPL56;MAAT1;C11orf4 NOF1;L23MRP RPL23L;MRP64;None;None;MRPL32 RPML32;None;None;MRPL8 RPML8;None;BMRP MRPL27 RPML27;None;None;MRPL28 RPML28;None;None;None;None;None;None;None;None;None;None;None;None;MRPL2 RPML2;None;C15orf4 LIECG2;None;NCM1;NLVCF URIM;LIP2;MRPL25 RPML25;None;C21orf92 MRPL5 RPML5;None;None;BRIP1;None;None;MRPL31 MRPS32 RPML31
328	Ku antigen complex	Human	Ku70-Ku80 complex; Ku complex	HeLa cells	P12956;P13010	2547;7520	MI:0029-cosedimentation through density gradient;MI:0091-chromatography technology	GO:0006281;GO:0003677;GO:0006974;GO:0005634	DNA repair;DNA binding;cellular response to DNA damage stimulus;nucleus	10.01.05.01;16.03.01;32.01.09;70.10	DNA repair;DNA binding;DNA damage response;nucleus	16713581	In the absence of added DNA Ku70-Ku80 copurify without DNA-PKcs.	None	None	Homo sapiens (Human);Homo sapiens (Human)	X-ray repair cross-complementing protein 6;X-ray repair cross-complementing protein 5	XRCC6;XRCC5	G22P1;G22P2
335	p54(nrb)-PSF-matrin3 complex	Human	None	None	P23246;P43243;Q15233	6421;9782;4841	MI:0030-cross-linking study	GO:0003723;GO:0050658;GO:0051033;GO:0005634	RNA binding;RNA transport;RNA transmembrane transporter activity;nucleus	16.03.03;20.01.21;70.10	RNA binding;RNA transport;nucleus	11525732	This complex binds specifically to inosine-containing RNAs and anchors hyperedited RNAs to the nuclear matrix.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Splicing factor, proline- and glutamine-rich;Matrin-3;Non-POU domain-containing octamer-binding protein	SFPQ;MATR3;NONO	PSF;KIAA0723;NRB54
336	DNA ligase IV-XRCC4-AHNK complex	Human	AHNAK-LX complex	None	P49917;Q09666;Q13426	3981;79026;7518	MI:0004-affinity chromatography technology;MI:0006-anti bait coimmunoprecipitation	GO:0006281;GO:0006312;GO:0003677;GO:0005634	DNA repair;mitotic recombination;DNA binding;nucleus	10.01.05.01;10.01.05.03.03;16.03.01;70.10	DNA repair;somatic / mitotic recombination;DNA binding;nucleus	15177040	AHNAK stimulates the double-stranded ligation activity of DNA ligase IV-XRCC4 complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA ligase 4;Neuroblast differentiation-associated protein AHNAK;DNA repair protein XRCC4	LIG4;AHNAK;XRCC4	None;PM227;None
338	40S ribosomal subunit, cytoplasmic	Human	small ribosomal subunit, cytoplasmic	HeLa cells	P08708;P08865;P15880;P23396;P25398;P39019;P46781;P46782;P46783;P60866;P61247;P62081;P62241;P62244;P62249;P62263;P62266;P62269;P62273;P62277;P62280;P62701;P62753;P62841;P62847;P62851;P62854;P62857;P62861;P62979;P63220	6218;3921;6187;6188;6206;6223;6203;6193;6204;6224;6189;6201;6202;6210;6217;6208;6228;6222;6235;6207;6205;6191;6194;6209;6229;6230;6231;6234;2197;6233;6227	MI:0004-affinity chromatography technology;MI:0029-cosedimentation through density gradient	GO:0006412;GO:0005737	translation;cytoplasm	12.04;70.03	translation;cytoplasm	15883184	None	None	RPS27 was not detected in this study. RPS4Y1 and RPSY2 could not be detected, since HeLa cells were used, which contain no Y chromosome.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	40S ribosomal protein S17;40S ribosomal protein SA;40S ribosomal protein S2;40S ribosomal protein S3;40S ribosomal protein S12;40S ribosomal protein S19;40S ribosomal protein S9;40S ribosomal protein S5;40S ribosomal protein S10;40S ribosomal protein S20;40S ribosomal protein S3a;40S ribosomal protein S7;40S ribosomal protein S8;40S ribosomal protein S15a;40S ribosomal protein S16;40S ribosomal protein S14;40S ribosomal protein S23;40S ribosomal protein S18;40S ribosomal protein S29;40S ribosomal protein S13;40S ribosomal protein S11;40S ribosomal protein S4, X isoform;40S ribosomal protein S6;40S ribosomal protein S15;40S ribosomal protein S24;40S ribosomal protein S25;40S ribosomal protein S26;40S ribosomal protein S28;FAU ubiquitin-like and ribosomal protein S30;Ubiquitin-40S ribosomal protein S27a;40S ribosomal protein S21	RPS17;RPSA;RPS2;RPS3;RPS12;RPS19;RPS9;RPS5;RPS10;RPS20;RPS3A;RPS7;RPS8;RPS15A;RPS16;RPS14;RPS23;RPS18;RPS29;RPS13;RPS11;RPS4X;RPS6;RPS15;RPS24;RPS25;RPS26;RPS28;FAU;RPS27A;RPS21	RPS17L;LAMBR LAMR1;RPS4;None;None;None;None;None;None;None;FTE1 MFTL;None;None;None;None;None;None;D6S218E;None;None;None;CCG2 RPS4 SCAR;None;RIG;None;None;None;None;None;UBA80 UBCEP1;None
343	Sarcoglycan-sarcospan complex SG-SPN	Human	None	None	Q13326;Q14714;Q16585;Q16586;Q92629	6445;8082;6443;6442;6444	MI:0019-coimmunoprecipitation	GO:0006941;GO:0007517;GO:0005886	striated muscle contraction;muscle organ development;plasma membrane	36.25.09.03;45.03.12;70.02	striated muscle contraction;muscle;eukaryotic plasma membrane / membrane attached	10189375	The authors demonstrate that assembly of the SG subcomplex is a prerequisite for targeting SPN to the sarcolemma and that the SG- SPN subcomplex functions to stabilize alpha -dystroglycan to the muscle plasma membrane.	SGCB, SGCG and SGCD are involved in muscular dystrophy and cardiomyopathy (PMID:15117830).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Gamma-sarcoglycan;Sarcospan;Beta-sarcoglycan;Alpha-sarcoglycan;Delta-sarcoglycan	SGCG;SSPN;SGCB;SGCA;SGCD	None;KRAG;None;ADL DAG2;None
348	DNA ligase IV-XRCC4 complex	Human	LX complex; LIG4-XRCC4 complex	lymphoblasts	P49917;Q13426	3981;7518	MI:0007-anti tag coimmunoprecipitation;MI:0030-cross-linking study;MI:0071-molecular sieving;MI:0404-comigration in non denaturing gel electrophoresis	GO:0003677;GO:0005634;GO:0006302	DNA binding;nucleus;double-strand break repair	16.03.01;70.10	DNA binding;nucleus	10945980	XRCC4 serves as a molecular bridge to target DNA ligase IV to a DNA double-strand break (PMID: 9259561). Cross-linking experiments suggest that an XRCC4\u00b7XRCC4 dimer interface forms the core of the tetramer, and that the DNL IV polypeptides are in contact with XRCC4 but not with one another. (PMID: 10945980)	None	Purification of this complex has been also described in PMID: 9242410, 9259561, 11702069, and 12589063.	Homo sapiens (Human);Homo sapiens (Human)	DNA ligase 4;DNA repair protein XRCC4	LIG4;XRCC4	None;None
350	DNA ligase IV-XRCC4-PNK complex	Human	None	None	P49917;Q13426;Q96T60	3981;7518;11284	MI:0007-anti tag coimmunoprecipitation	GO:0006281;GO:0005694	DNA repair;chromosome	10.01.05.01;70.10.03	DNA repair;chromosome	15385968	Interaction of PNK with XRCC4 is dependent on the phosphothreonine-binding activity of the FHA domain.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA ligase 4;DNA repair protein XRCC4;Bifunctional polynucleotide phosphatase/kinase	LIG4;XRCC4;PNKP	None;None;None
353	DNA ligase IV-condensin complex	Human	None	None	O95347;P49917;Q9NTJ3	10592;3981;10051	MI:0019-coimmunoprecipitation;MI:0402-chromatin immunoprecipitation assay;MI:0428-imaging technique	GO:0006281;GO:0007049;GO:0005694	DNA repair;cell cycle;chromosome	10.01.05.01;10.03;70.10.03	DNA repair;cell cycle;chromosome	12589063	DNA ligase IV interacts with SMC2L1 protein.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Structural maintenance of chromosomes protein 2;DNA ligase 4;Structural maintenance of chromosomes protein 4	SMC2;LIG4;SMC4	CAPE SMC2L1;None;CAPC SMC4L1
359	DNA ligase IV-XRCC4-XLF complex	Human	None	None	P49917;Q13426;Q9H9Q4	3981;7518;79840	MI:0007-anti tag coimmunoprecipitation	GO:0006281;GO:0005634	DNA repair;nucleus	10.01.05.01;70.10	DNA repair;nucleus	16439205	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA ligase 4;DNA repair protein XRCC4;Non-homologous end-joining factor 1	LIG4;XRCC4;NHEJ1	None;None;XLF
361	Artemis-DNA-PK complex	Human	None	HEK293T cells	P78527;Q96SD1	5591;64421	MI:0007-anti tag coimmunoprecipitation	GO:0006281;GO:0003677;GO:0006974;GO:0005634;GO:0004519;GO:0033151	DNA repair;DNA binding;cellular response to DNA damage stimulus;nucleus;endonuclease activity;V(D)J recombination	10.01.05.01;16.03.01;32.01.09;70.10	DNA repair;DNA binding;DNA damage response;nucleus	11955432	Upon complex formation, DNA-PKcs phosphorylates Artemis, and Artemis acquires endonucleolytic activity on 5' and 3' overhangs, as well as hairpins. Finally, the Artemis:DNA-PKcs complex can open hairpins generated by the RAG complex.	None	None	Homo sapiens (Human);Homo sapiens (Human)	DNA-dependent protein kinase catalytic subunit;Protein artemis	PRKDC;DCLRE1C	HYRC HYRC1;ARTEMIS ASCID SCIDA SNM1C
362	DNA ligase III-XRCC1-PNK-DNA-pol III multiprotein complex	Human	None	None	P06746;P18887;P49916;Q96T60	5423;7515;3980;11284	MI:0006-anti bait coimmunoprecipitation	GO:0006281;GO:0006974;GO:0005634	DNA repair;cellular response to DNA damage stimulus;nucleus	10.01.05.01;32.01.09;70.10	DNA repair;DNA damage response;nucleus	11163244	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA polymerase beta;DNA repair protein XRCC1;DNA ligase 3;Bifunctional polynucleotide phosphatase/kinase	POLB;XRCC1;LIG3;PNKP	None;None;None;None
365	DNA ligase III-XRCC1 complex	Human	LIG3-XRCC1 complex	HeLa cells	P18887;P49916	7515;3980	MI:0071-molecular sieving	GO:0006281;GO:0005634	DNA repair;nucleus	10.01.05.01;70.10	DNA repair;nucleus	16060670	DNA polymerase beta promotes recruitment of the DNA ligase III-XRCC1 complex to sites of base excision repair. However, Pol-beta is not stably complexed with the XRCC1-Lig3 heterodimer.	None	None	Homo sapiens (Human);Homo sapiens (Human)	DNA repair protein XRCC1;DNA ligase 3	XRCC1;LIG3	None;None
368	ERCC1-ERCC4-MSH2 complex	Human	None	None	P07992;P43246;Q92889	2067;4436;2072	MI:0006-anti bait coimmunoprecipitation;MI:0071-molecular sieving	GO:0006308;GO:0006281;GO:0006974;GO:0005634	DNA catabolic process;DNA repair;cellular response to DNA damage stimulus;nucleus	01.03.16.03;10.01.05.01;32.01.09;70.10	DNA degradation;DNA repair;DNA damage response;nucleus	14706347	None	ERCC4 is involved in xeroderma pigmentosum group F.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA excision repair protein ERCC-1;DNA mismatch repair protein Msh2;DNA repair endonuclease XPF	ERCC1;MSH2;ERCC4	None;None;ERCC11 XPF
369	MSH2-MSH6-PMS2-MLH1 complex	Human	MMR complex 2	HeLa nuclear extracts	P40692;P43246;P52701;P54278	4292;4436;2956;5395	MI:0006-anti bait coimmunoprecipitation;MI:0031-protein cross-linking with a bifunctional reagent	GO:0006281;GO:0003677;GO:0006974;GO:0005634	DNA repair;DNA binding;cellular response to DNA damage stimulus;nucleus	10.01.05.01;16.03.01;32.01.09;70.10	DNA repair;DNA binding;DNA damage response;nucleus	10748159	The protein complex specifically binds to mismatched DNA. Interactions occur without addition of ATP.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA mismatch repair protein Mlh1;DNA mismatch repair protein Msh2;DNA mismatch repair protein Msh6;Mismatch repair endonuclease PMS2	MLH1;MSH2;MSH6;PMS2	COCA2;None;GTBP;PMSL2
370	MSH2-MSH6-PMS1-MLH1 complex	Human	MMR complex 1	None	P40692;P43246;P52701;P54277	4292;4436;2956;5378	MI:0006-anti bait coimmunoprecipitation;MI:0031-protein cross-linking with a bifunctional reagent	GO:0006281;GO:0003677;GO:0006974;GO:0005634	DNA repair;DNA binding;cellular response to DNA damage stimulus;nucleus	10.01.05.01;16.03.01;32.01.09;70.10	DNA repair;DNA binding;DNA damage response;nucleus	10748159	The protein complex specifically binds to mismatched DNA. Interactions occur without addition of ATP.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA mismatch repair protein Mlh1;DNA mismatch repair protein Msh2;DNA mismatch repair protein Msh6;PMS1 protein homolog 1	MLH1;MSH2;MSH6;PMS1	COCA2;None;GTBP;PMSL1
376	PCNA-MutS-alpha-MutL-alpha-DNA complex	Human	PCNA-MSH2-MSH6-MLH1-PMS2 complex	HeLa cells	P12004;P40692;P43246;P52701;P54278	5111;4292;4436;2956;5395	MI:0019-coimmunoprecipitation;MI:0031-protein cross-linking with a bifunctional reagent	GO:0006281;GO:0003677;GO:0006974;GO:0005634	DNA repair;DNA binding;cellular response to DNA damage stimulus;nucleus	10.01.05.01;16.03.01;32.01.09;70.10	DNA repair;DNA binding;DNA damage response;nucleus	16204460	MutS-alpha, consisting of MSH2 and MSH6 proteins, and PCNA bind to DNA to form an initial complex. MutL-alpha, consisting of MLH1 and PMS2, binds to the complex when the DNA is damaged.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Proliferating cell nuclear antigen;DNA mismatch repair protein Mlh1;DNA mismatch repair protein Msh2;DNA mismatch repair protein Msh6;Mismatch repair endonuclease PMS2	PCNA;MLH1;MSH2;MSH6;PMS2	None;COCA2;None;GTBP;PMSL2
379	MutL-alpha complex	Human	MLH1-PMS2 complex	HCT-116, N87, SNU-1, SNU-638, HeLa, AGS, KATO-III, and SNU-16 cells	P40692;P54278	4292;5395	MI:0006-anti bait coimmunoprecipitation	GO:0006281;GO:0003677;GO:0006974;GO:0005634	DNA repair;DNA binding;cellular response to DNA damage stimulus;nucleus	10.01.05.01;16.03.01;32.01.09;70.10	DNA repair;DNA binding;DNA damage response;nucleus	10748105	Normal levels of hMLH1 protein appear to be important in maintaining normal levels of hPMS1 and hPMS2 proteins, suggesting that PMS proteins are unstable in the absence of hMLH1.	None	None	Homo sapiens (Human);Homo sapiens (Human)	DNA mismatch repair protein Mlh1;Mismatch repair endonuclease PMS2	MLH1;PMS2	COCA2;PMSL2
380	MutL-beta complex	Human	MLH1-PMS1 complex	None	P40692;P54277	4292;5378	MI:0006-anti bait coimmunoprecipitation	GO:0006281;GO:0003677;GO:0006974;GO:0005634	DNA repair;DNA binding;cellular response to DNA damage stimulus;nucleus	10.01.05.01;16.03.01;32.01.09;70.10	DNA repair;DNA binding;DNA damage response;nucleus	10748105	The results provide evidence for the association of hPMS1 with hMLH1 as a heterodimer in human epithelial cancer cells. Normal levels of hMLH1 protein appear to be important in maintaining normal levels of hPMS1 and hPMS2 proteins, suggesting that PMS proteins are unstable in the absence of hMLH1.	None	None	Homo sapiens (Human);Homo sapiens (Human)	DNA mismatch repair protein Mlh1;PMS1 protein homolog 1	MLH1;PMS1	COCA2;PMSL1
386	Ubiquitin E3 ligase (UBADC1, RNF123)	Human	KPC complex; KPC1-KPC2 ubiquitin-protein ligase	None	Q5XPI4;Q9BSL1	63891;10422	MI:0007-anti tag coimmunoprecipitation	GO:0016567;GO:0043161;GO:0006511;GO:0005515;GO:0005737	protein ubiquitination;proteasome-mediated ubiquitin-dependent protein catabolic process;ubiquitin-dependent protein catabolic process;protein binding;cytoplasm	14.07.05;14.13.01.01;16.01;70.03	modification by ubiquitination, deubiquitination;proteasomal degradation (ubiquitin/proteasomal pathway);protein binding;cytoplasm	15531880	Ubiquitin E3 ligases covalently attach ubiquitin to a lysine residue on a target protein. Polyubiquitination marks proteins for degradation by the proteasome. The cyclin-dependent kinase inhibitor p27(Kip1) is degraded at the G0-G1 transition of the cell cycle by the ubiquitin-proteasome pathway. Overexpression of KPC promoted the degradation of p27(Kip1), whereas a dominant-negative mutant of KPC1 delayed p27(Kip1) degradation. The nuclear export of p27(Kip1) by CRM1 seems to be necessary for KPC-mediated proteolysis.	None	None	Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase RNF123;Ubiquitin-associated domain-containing protein 1	RNF123;UBAC1	KPC1;GBDR1 KPC2 UBADC1
387	MCM complex	Human	None	None	P25205;P33991;P33992;P33993;P49736;Q14566	4172;4173;4174;4176;4171;4175	MI:0226-ion exchange chromatography	GO:0051276;GO:0006260;GO:0005524;GO:0005694	chromosome organization;DNA replication;ATP binding;chromosome	42.10.03;10.01.03;16.19.03;70.10.03	organization of chromosome structure;DNA synthesis and replication;ATP binding;chromosome	8798650	None	The MCM proteins are highly expressed in malignant human cancer cells and pre-cancerous cells undergoing malignant transformation (PMID:16101384).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA replication licensing factor MCM3;DNA replication licensing factor MCM4;DNA replication licensing factor MCM5;DNA replication licensing factor MCM7;DNA replication licensing factor MCM2;DNA replication licensing factor MCM6	MCM3;MCM4;MCM5;MCM7;MCM2;MCM6	None;CDC21;CDC46;CDC47 MCM2;BM28 CCNL1 CDCL1 KIAA0030;None
390	Ubiquitin E3 ligase (SKP1A, FBXW2, CUL1)	Human	SCF(hFBW2) E3 complex	None	P63208;Q13616;Q9UKT8	6500;8454;26190	MI:0007-anti tag coimmunoprecipitation	GO:0016567;GO:0043161;GO:0006511;GO:0005515;GO:0030878;GO:0005737	protein ubiquitination;proteasome-mediated ubiquitin-dependent protein catabolic process;ubiquitin-dependent protein catabolic process;protein binding;thyroid gland development;cytoplasm	14.07.05;14.13.01.01;16.01;47.03.21.03.06;70.03	modification by ubiquitination, deubiquitination;proteasomal degradation (ubiquitin/proteasomal pathway);protein binding;thyroid gland;cytoplasm	15640526	The GCM proteins GCMa/1 and GCMb/2 are novel zinc-containing transcription factors critical for glial cell differentiation in fly and for placental as well as parathyroid gland development in mouse. Experiments identify the SCF(hFBW2) E3 complex as the key machinery that targets hGCMa to the ubiquitin-proteasome degradation system.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	S-phase kinase-associated protein 1;Cullin-1;F-box/WD repeat-containing protein 2	SKP1;CUL1;FBXW2	EMC19 OCP2 SKP1A TCEB1L;None;FBW2 FWD2
391	Ubiquitin E3 ligase (DDB1, CUL4A, RBX1)	Human	Ddb1-Cul4a-Roc1 complex; CUL4-DDB1 E3 ubiquitin ligase	HEK293T cells	P62877;Q13619;Q16531	9978;8451;1642	MI:0676-tandem affinity purification	GO:0016567;GO:0005515;GO:0006974;GO:0006511;GO:0045087;GO:0051607;GO:0019048	protein ubiquitination;protein binding;cellular response to DNA damage stimulus;ubiquitin-dependent protein catabolic process;innate immune response;defense response to virus;modulation by virus of host process	14.07.05;16.01;32.01.09;14.13.01.01;36.25.16.01	modification by ubiquitination, deubiquitination;protein binding;DNA damage response;proteasomal degradation (ubiquitin/proteasomal pathway);innate immune response (invertebrates and vertebrates)	16964240	Ubiquitin E3 ligases covalently attach ubiquitin to a lysine residue on a target protein. Polyubiquitination marks proteins for degradation by the proteasome (PMID: 16964240). Viruses have evolved several strategies to evade the immune system of the host. Hepatitis B virus X protein, like paramyxovirus SV5-V protein, hijack the CUL4-DDB1 E3 ubiquitin ligase complex to promote polyubiquitination and rapid turnover of STAT proteins, thereby blocking the antiviral response of the host cells (PMID:19966799, PMID:10559305).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase RBX1;Cullin-4A;DNA damage-binding protein 1	RBX1;CUL4A;DDB1	RNF75 ROC1;None;XAP1
393	Succinyl-CoA synthetase, GDP-forming	Human	succinyl-CoA ligase	None	P53597;Q96I99	8802;8801	MI:0027-cosedimentation	GO:0006163;GO:0006144;GO:0008152;GO:0005515;GO:0005525;GO:0005739	purine nucleotide metabolic process;purine nucleobase metabolic process;metabolic process;protein binding;GTP binding;mitochondrion	01.03.01;01;16.01;16.19.05;70.16	purin nucleotide/nucleoside/nucleobase metabolism;METABOLISM;protein binding;GTP binding;mitochondrion	15234968	None	A deletion in SUCLG1, a gene that encodes the alpha subunit of the Krebs-cycle enzyme succinate-coenzyme A ligase (SUCL) causes fatal infantile lactic acidosis(PMID:17668387).	None	Homo sapiens (Human);Homo sapiens (Human)	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial;Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial	SUCLG1;SUCLG2	None;None
394	Succinyl-CoA synthetase, ADP-forming	Human	succinyl-CoA ligase	None	P53597;Q9P2R7	8802;8803	MI:0027-cosedimentation	GO:0006163;GO:0006144;GO:0008152;GO:0005515;GO:0005524;GO:0005739	purine nucleotide metabolic process;purine nucleobase metabolic process;metabolic process;protein binding;ATP binding;mitochondrion	01.03.01;01;16.01;16.19.03;70.16	purin nucleotide/nucleoside/nucleobase metabolism;METABOLISM;protein binding;ATP binding;mitochondrion	15234968	None	A deletion in SUCLG1, a gene that encodes the alpha subunit of the Krebs-cycle enzyme succinate-coenzyme A ligase (SUCL) causes fatal infantile lactic acidosis(PMID:17668387).	None	Homo sapiens (Human);Homo sapiens (Human)	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial;Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	SUCLG1;SUCLA2	None;None
404	Isocitrate dehydrogenase, cytoplasmic	Human	IDH1 homodimer	None	O75874	3417	MI:0096-pull down	GO:0008152;GO:0050661;GO:0005737;GO:0005777	metabolic process;NADP binding;cytoplasm;peroxisome	01;16.21.07;70.03;70.19	METABOLISM;NAD/NADP binding;cytoplasm;peroxisome	15173171	Isocitrate dehydrogenases (IDHs) catalyze the oxidative decarboxylation of isocitrate to alpha-ketoglutarate. The isocitrate dehydrogenase complex appears as homodimer.	None	None	Homo sapiens (Human)	Isocitrate dehydrogenase [NADP] cytoplasmic	IDH1	PICD
407	Guanylyl cyclase, soluble (GUCY1A2, GUCY1B3)	Human	None	None	P33402;Q02153	2977;2983	MI:0028-cosedimentation in solution	GO:0009187;GO:0005515;GO:0005737	cyclic nucleotide metabolic process;protein binding;cytoplasm	01.03.10;16.01;70.03	metabolism of cyclic and unusual nucleotides;protein binding;cytoplasm	1683630	Two soluble guanylyl cyclase complexes were found in mammals.  The GUCY1A3-GUCY1B3 complex exhibits higher guanylyl cyclase activity than the GUCY1A2-GUCY1B3 complex.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Guanylate cyclase soluble subunit alpha-2;Guanylate cyclase soluble subunit beta-1	GUCY1A2;GUCY1B1	GUC1A2 GUCSA2;GUC1B3 GUCSB3 GUCY1B3
408	Guanylyl cyclase, soluble (GUCY1A3, GUCY1B3)	Human	None	None	Q02108;Q02153	2982;2983	MI:0028-cosedimentation in solution	GO:0009187;GO:0005515;GO:0005737	cyclic nucleotide metabolic process;protein binding;cytoplasm	01.03.10;16.01;70.03	metabolism of cyclic and unusual nucleotides;protein binding;cytoplasm	1683630	Two soluble guanylyl cyclase complexes were found in mammals.  The GUCY1A3-GUCY1B3 complex exhibits higher guanylyl cyclase activity than the GUCY1A2-GUCY1B3 complex.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Guanylate cyclase soluble subunit alpha-1;Guanylate cyclase soluble subunit beta-1	GUCY1A1;GUCY1B1	GUC1A3 GUCSA3 GUCY1A3;GUC1B3 GUCSB3 GUCY1B3
415	EXO1-MLH1-PMS2 complex	Human	None	HeLa cells	P40692;P54278;Q9UQ84	4292;5395;9156	MI:0006-anti bait coimmunoprecipitation	GO:0006308;GO:0006974;GO:0005634;GO:0006298	DNA catabolic process;cellular response to DNA damage stimulus;nucleus;mismatch repair	01.03.16.03;32.01.09;70.10	DNA degradation;DNA damage response;nucleus	11427529	The authors propose  the involvement of hExoI as a downstream effector in MMR (DNA mismatch repair) and/or DNA recombination.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA mismatch repair protein Mlh1;Mismatch repair endonuclease PMS2;Exonuclease 1	MLH1;PMS2;EXO1	COCA2;PMSL2;EXOI HEX1
419	Farnesyltransferase	Human	None	None	P49354;P49356	2339;2342	MI:0114-x-ray crystallography	GO:0006497;GO:0005515	protein lipidation;protein binding	14.07.01;16.01	modification with fatty acids (e.g. myristylation, palmitylation, farnesylation);protein binding	11687658	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha;Protein farnesyltransferase subunit beta	FNTA;FNTB	None;None
422	CAV3-DAG1 complex	Human	Beta-dystroglycan-caveolin-3 complex	muscle	P56539;Q14118	859;1605	MI:0019-coimmunoprecipitation;MI:0029-cosedimentation through density gradient;MI:0096-pull down	GO:0005886;GO:0065003	plasma membrane;protein-containing complex assembly	70.02	eukaryotic plasma membrane / membrane attached	10988290	Caveolin-3 can effectively block the interaction of dystrophin with beta-dystroglycan.	DAG1 is involved in muscular dystrophy and cardiomyopathy (PMID:15117830).	None	Homo sapiens (Human);Homo sapiens (Human)	Caveolin-3;Dystroglycan 1	CAV3;DAG1	None;None
424	EXO1-MLH1-PCNA complex	Human	None	in vitro	P12004;P40692;Q9UQ84	5111;4292;9156	MI:0663-confocal microscopy	GO:0006308;GO:0006281;GO:0006974;GO:0005634	DNA catabolic process;DNA repair;cellular response to DNA damage stimulus;nucleus	01.03.16.03;10.01.05.01;32.01.09;70.10	DNA degradation;DNA repair;DNA damage response;nucleus	14676842	EXO1 plays a role in events at the replication sites as well as a functional role in the DNA mismatch repair and/or recombination processes.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Proliferating cell nuclear antigen;DNA mismatch repair protein Mlh1;Exonuclease 1	PCNA;MLH1;EXO1	None;COCA2;EXOI HEX1
425	MSH4-MSH5-GPS2 complex	Human	None	None	O15457;O43196;Q13227	4438;4439;2874	MI:0007-anti tag coimmunoprecipitation;MI:0096-pull down;MI:0437-protein three hybrid	GO:0006281;GO:0007131;GO:0006974	DNA repair;reciprocal meiotic recombination;cellular response to DNA damage stimulus	10.01.05.01;10.01.05.03.01;32.01.09	DNA repair;meiotic recombination;DNA damage response	16122992	The association with GPS2 is mediated through the interface of hMSH4-hMSH5 complex and the N-terminal region of GPS2.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	MutS protein homolog 4;MutS protein homolog 5;G protein pathway suppressor 2	MSH4;MSH5;GPS2	None;None;None
426	Meprin A	Human	PABA peptide hydrolase	None	Q16819;Q16820	4224;4225	MI:0019-coimmunoprecipitation	GO:0005515;GO:0005886;GO:0030163	protein binding;plasma membrane;protein catabolic process	16.01;70.02;14.13	protein binding;eukaryotic plasma membrane / membrane attached;protein/peptide degradation	8262185	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Meprin A subunit alpha;Meprin A subunit beta	MEP1A;MEP1B	None;None
428	Molybdopterin synthase	Human	None	in vitro	O96007;O96033	4338;4338	MI:0071-molecular sieving	GO:0051191;GO:0009110;GO:0005515;GO:0032324	prosthetic group biosynthetic process;vitamin biosynthetic process;protein binding;molybdopterin cofactor biosynthetic process	01.07.01;16.01	biosynthesis of vitamins, cofactors, and prosthetic groups;protein binding	12732628	Molybdenum cofactor (Moco)1 biosynthesis is an ancient, ubiquitous, and highly conserved pathway leading to the biochemical activation of molybdenum. Moco is essential for the activity of sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase in humans. MOCS2A and MOCS2B are encoded on a single bicistronic mRNA.	Human Moco deficiency leads to the pleiotropic loss of all three of these molybdoenzymes and usually progresses to death at an early age.	None	Homo sapiens (Human);Homo sapiens (Human)	Molybdopterin synthase catalytic subunit;Molybdopterin synthase sulfur carrier subunit	MOCS2;MOCS2	MCBPE MOCO1;MOCO1
429	Phosphatidylinositol 3-kinase complex (PIK3C3, PIK3R4)	Human	Ptdlns 3-kinase-pl150 complex	U937 cells, Jurkat 6 cells, HL60 cells	Q8NEB9;Q99570	5289;30849	MI:0019-coimmunoprecipitation	GO:0006605;GO:0005515;GO:0007167;GO:0005886;GO:0046854;GO:0090160	protein targeting;protein binding;enzyme-linked receptor protein signaling pathway;plasma membrane;phosphatidylinositol phosphate biosynthetic process;Golgi to lysosome transport	14.04;16.01;30.05.01;70.02	protein targeting, sorting and translocation;protein binding;receptor enzyme mediated signalling;eukaryotic plasma membrane / membrane attached	7628435	The homologous Vps34p-Vps15p complex in yeast mediates protein trafficking. Both human Ptdlns 3-kinase (VPS34) and  yeast Vps34p have identical restricted specificities, using only Ptdlns and not PtdIns4P or PtdIns(4,5P)2 as substrate.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Phosphatidylinositol 3-kinase catalytic subunit type 3;Phosphoinositide 3-kinase regulatory subunit 4	PIK3C3;PIK3R4	VPS34;VPS15
430	18S U11/U12 snRNP	Human	None	None	O43143;O75533;P14678;P62304;P62306;P62308;P62314;P62316;P62318;P67809;Q13435;Q15393;Q15427;Q15696;Q16560;Q6IEG0;Q6P2Q9;Q8N8D1;Q8TBF4;Q96LT9;Q9BV90;Q9BWJ5;Q9UDW3;Q9Y3B4	1665;23451;6628;6635;6636;6637;6632;6633;6634;4904;10992;23450;10262;8233;11066;154007;10594;10081;85437;55599;79622;83443;55954;51639	MI:0029-cosedimentation through density gradient;MI:0069-mass spectrometry studies of complexes	GO:0000398;GO:0006397;GO:0005634	mRNA splicing, via spliceosome;mRNA processing;nucleus	11.04.03;70.10	mRNA processing (splicing, 5'-, 3'-end processing);nucleus	15146077	U12-type spliceosomes excise U12-type introns, which comprise less than 1% of all human introns.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	ATP-dependent RNA helicase DHX15;Splicing factor 3B subunit 1;Small nuclear ribonucleoprotein-associated proteins B and B';Small nuclear ribonucleoprotein E;Small nuclear ribonucleoprotein F;Small nuclear ribonucleoprotein G;Small nuclear ribonucleoprotein Sm D1;Small nuclear ribonucleoprotein Sm D2;Small nuclear ribonucleoprotein Sm D3;Y-box-binding protein 1;Splicing factor 3B subunit 2;Splicing factor 3B subunit 3;Splicing factor 3B subunit 4;U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2;U11/U12 small nuclear ribonucleoprotein 35 kDa protein;U11/U12 small nuclear ribonucleoprotein 48 kDa protein;Pre-mRNA-processing-splicing factor 8;Programmed cell death protein 7;Zinc finger CCHC-type and RNA-binding motif-containing protein 1;RNA-binding region-containing protein 3;U11/U12 small nuclear ribonucleoprotein 25 kDa protein;Splicing factor 3B subunit 5;Zinc finger matrin-type protein 5;Splicing factor 3B subunit 6	DHX15;SF3B1;SNRPB;SNRPE;SNRPF;SNRPG;SNRPD1;SNRPD2;SNRPD3;YBX1;SF3B2;SF3B3;SF3B4;ZRSR2;SNRNP35;SNRNP48;PRPF8;PDCD7;ZCRB1;RNPC3;SNRNP25;SF3B5;ZMAT5;SF3B6	DBP1 DDX15;SAP155;COD SNRPB1;None;PBSCF;PBSCG;None;SNRPD1;None;NSEP1 YB1;SAP145;KIAA0017 SAP130;SAP49;U2AF1-RS2 U2AF1L2 U2AF1RS2 URP;HM1 U1SNRNPBP;C6orf151;PRPC8;None;None;KIAA1839 RBM40 RNP SNRNP65;C16orf33;SF3B10;None;SAP14 SF3B14 SF3B14A
432	N-NOS-CHIP-HSP70-1 complex	Human	None	None	P0DMV8;P29475;Q9UNE7	3303;4842;10273	MI:0019-coimmunoprecipitation	GO:0043161;GO:0006511;GO:0005737	proteasome-mediated ubiquitin-dependent protein catabolic process;ubiquitin-dependent protein catabolic process;cytoplasm	14.13.01.01;70.03	proteasomal degradation (ubiquitin/proteasomal pathway);cytoplasm	15466472	Cells for analysis were treated with lactacystin, a selective inhibitor of the proteasome. The authors found that CHIP acts to ubiquitylate nNOS and that hsp70 and hsp40 can facilitate this conjugation reaction.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Heat shock 70 kDa protein 1A;Nitric oxide synthase, brain;E3 ubiquitin-protein ligase CHIP	HSPA1A;NOS1;STUB1	HSP72 HSPA1 HSX70;None;CHIP
433	BASC complex (BRCA1-associated genome surveillance complex)	Human	None	None	O60934;P35249;P35250;P35251;P38398;P40692;P43246;P49959;P52701;P54132;Q13315;Q92878	4683;5984;5982;5981;672;4292;4436;4361;2956;641;472;10111	MI:0019-coimmunoprecipitation;MI:0071-molecular sieving;MI:0226-ion exchange chromatography	GO:0006281;GO:0006974;GO:0005634	DNA repair;cellular response to DNA damage stimulus;nucleus	10.01.05.01;32.01.09;70.10	DNA repair;DNA damage response;nucleus	10783165	The BASC complex may serve as a sensor for DNA damage.	BRCA1 is involved in breast cancer.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Nibrin;Replication factor C subunit 4;Replication factor C subunit 2;Replication factor C subunit 1;Breast cancer type 1 susceptibility protein;DNA mismatch repair protein Mlh1;DNA mismatch repair protein Msh2;Double-strand break repair protein MRE11;DNA mismatch repair protein Msh6;RecQ-like DNA helicase BLM;Serine-protein kinase ATM;DNA repair protein RAD50	NBN;RFC4;RFC2;RFC1;BRCA1;MLH1;MSH2;MRE11;MSH6;BLM;ATM;RAD50	NBS NBS1 P95;None;None;RFC140;RNF53;COCA2;None;HNGS1 MRE11A;GTBP;RECQ2 RECQL3;None;None
434	BASC (Ab 80) complex (BRCA1-associated genome surveillance complex)	Human	None	None	P35249;P35250;P35251;P38398;P40692;P43246;P52701;P54132	5984;5982;5981;672;4292;4436;2956;641	MI:0007-anti tag coimmunoprecipitation	GO:0006281;GO:0006974;GO:0005634	DNA repair;cellular response to DNA damage stimulus;nucleus	10.01.05.01;32.01.09;70.10	DNA repair;DNA damage response;nucleus	10783165	For isolation of the BASC complex (Ab 80), polyclonal antibodies against GST-BRCA1 1021-1552 were used.	BRCA1 is involved in breast cancer.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Replication factor C subunit 4;Replication factor C subunit 2;Replication factor C subunit 1;Breast cancer type 1 susceptibility protein;DNA mismatch repair protein Mlh1;DNA mismatch repair protein Msh2;DNA mismatch repair protein Msh6;RecQ-like DNA helicase BLM	RFC4;RFC2;RFC1;BRCA1;MLH1;MSH2;MSH6;BLM	None;None;RFC140;RNF53;COCA2;None;GTBP;RECQ2 RECQL3
435	BASC (Ab 81) complex (BRCA1-associated genome surveillance complex)	Human	None	None	P35249;P35250;P35251;P38398;P40692;Q13315	5984;5982;5981;672;4292;472	MI:0019-coimmunoprecipitation;MI:0071-molecular sieving;MI:0226-ion exchange chromatography	GO:0006281;GO:0006974;GO:0005634	DNA repair;cellular response to DNA damage stimulus;nucleus	10.01.05.01;32.01.09;70.10	DNA repair;DNA damage response;nucleus	10783165	For isolation of the BASC complex (Ab 81), polyclonal antibodies against GST-BRCA1 1501-1861 were used.	BRCA1 is involved in breast cancer.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Replication factor C subunit 4;Replication factor C subunit 2;Replication factor C subunit 1;Breast cancer type 1 susceptibility protein;DNA mismatch repair protein Mlh1;Serine-protein kinase ATM	RFC4;RFC2;RFC1;BRCA1;MLH1;ATM	None;None;RFC140;RNF53;COCA2;None
436	BASC (Ab C-20) complex (BRCA1-associated genome surveillance complex)	Human	None	None	P38398;P52701;Q92878	672;2956;10111	MI:0007-anti tag coimmunoprecipitation	GO:0006281;GO:0006974;GO:0005634	DNA repair;cellular response to DNA damage stimulus;nucleus	10.01.05.01;32.01.09;70.10	DNA repair;DNA damage response;nucleus	10783165	For isolation of the BASC complex (Ab C-20), polyclonal antibodies against the carboxy-terminal epitope of BRCA1 were used.	BRCA1 is involved in breast cancer.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Breast cancer type 1 susceptibility protein;DNA mismatch repair protein Msh6;DNA repair protein RAD50	BRCA1;MSH6;RAD50	RNF53;GTBP;None
438	GCN5-TRRAP histone acetyltransferase complex	Human	GCN5-TRRAP-HAT complex	None	O75486;O75528;O75529;P38398;P43246;P52701;Q12962;Q16594;Q92830;Q9Y4A5	8464;10474;27097;672;4436;2956;6881;6880;2648;8295	MI:0004-affinity chromatography technology;MI:0029-cosedimentation through density gradient	GO:0006281;GO:0006265;GO:2001141;GO:0006355;GO:0006974;GO:0051276	DNA repair;DNA topological change;regulation of RNA biosynthetic process;regulation of DNA-templated transcription;cellular response to DNA damage stimulus;chromosome organization	10.01.05.01;10.01.09.05;11.02.03.04;32.01.09;42.10.03	DNA repair;DNA conformation modification (e.g. chromatin);transcriptional control;DNA damage response;organization of chromosome structure	16260778	hGCN5/TRRAP HAT complex subclass is required for the multiple functions of BRCA1 (PMID:16260778).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transcription initiation protein SPT3 homolog;Transcriptional adapter 3;TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L;Breast cancer type 1 susceptibility protein;DNA mismatch repair protein Msh2;DNA mismatch repair protein Msh6;Transcription initiation factor TFIID subunit 10;Transcription initiation factor TFIID subunit 9;Histone acetyltransferase KAT2A;Transformation/transcription domain-associated protein	SUPT3H;TADA3;TAF5L;BRCA1;MSH2;MSH6;TAF10;TAF9;KAT2A;TRRAP	SPT3;ADA3 TADA3L;PAF65B;RNF53;None;GTBP;TAF2A TAF2H TAFII30;TAF2G TAFII31;GCN5 GCN5L2;PAF400
441	TFTC-type histone acetyl transferase complex	Human	None	None	O60244;O75448;P03372;Q15648;Q92830;Q93074;Q9NVC6;Q9UHV7;Q9ULK4;Q9Y2X0;Q9Y4A5	9282;9862;2099;5469;2648;9968;9440;9969;9439;10025;8295	MI:0029-cosedimentation through density gradient;MI:0091-chromatography technology;MI:0096-pull down	GO:0006265;GO:2001141;GO:0006355;GO:0023052;GO:0051276;GO:0005634;GO:0005102;GO:0016573	DNA topological change;regulation of RNA biosynthetic process;regulation of DNA-templated transcription;signaling;chromosome organization;nucleus;signaling receptor binding;histone acetylation	10.01.09.05;11.02.03.04;30.01;42.10.03;70.10;16.01.01	DNA conformation modification (e.g. chromatin);transcriptional control;cellular signalling;organization of chromosome structure;nucleus;receptor binding	11931763	This complex is a coactivator of estrogen receptor alpha (ERalpha).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mediator of RNA polymerase II transcription subunit 14;Mediator of RNA polymerase II transcription subunit 24;Estrogen receptor;Mediator of RNA polymerase II transcription subunit 1;Histone acetyltransferase KAT2A;Mediator of RNA polymerase II transcription subunit 12;Mediator of RNA polymerase II transcription subunit 17;Mediator of RNA polymerase II transcription subunit 13;Mediator of RNA polymerase II transcription subunit 23;Mediator of RNA polymerase II transcription subunit 16;Transformation/transcription domain-associated protein	MED14;MED24;ESR1;MED1;KAT2A;MED12;MED17;MED13;MED23;MED16;TRRAP	ARC150 CRSP2 CXorf4 DRIP150 EXLM1 RGR1 TRAP170;ARC100 CRSP4 DRIP100 KIAA0130 THRAP4 TRAP100;ESR NR3A1;ARC205 CRSP1 CRSP200 DRIP205 DRIP230 PBP PPARBP PPARGBP RB18A TRAP220 TRIP2;GCN5 GCN5L2;ARC240 CAGH45 HOPA KIAA0192 TNRC11 TRAP230;ARC77 CRSP6 DRIP77 DRIP80 TRAP80;ARC250 KIAA0593 THRAP1 TRAP240;ARC130 CRSP3 DRIP130 KIAA1216 SUR2;DRIP92 THRAP5;PAF400
443	BP-SMAD complex	Human	None	trunk; head	O14867;O15198;O95452;P17980;P19447;P50539;Q13118;Q15582	571;4093;10804;5702;2071;4601;7071;7045	MI:0019-coimmunoprecipitation	GO:0045893;GO:0005634	positive regulation of DNA-templated transcription;nucleus	11.02.03.04.01;70.10	transcription activation;nucleus	16101586	Homozygous knockout mice for the homeobox protein Msx1 (Hox7) die at birth exhibiting severe abnormalities limited to the craniofacial region, including a complete cleft of the secondary palate. Results suggest that the BP-SMAD complex is required for transcriptional activation of the mouse Msx1 gene.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transcription regulator protein BACH1;Mothers against decapentaplegic homolog 9;Gap junction beta-6 protein;26S proteasome regulatory subunit 6A;General transcription and DNA repair factor IIH helicase subunit XPB;Max-interacting protein 1;Krueppel-like factor 10;Transforming growth factor-beta-induced protein ig-h3	BACH1;SMAD9;GJB6;PSMC3;ERCC3;MXI1;KLF10;TGFBI	None;MADH6 MADH9 SMAD8;None;TBP1;XPB XPBC;BHLHC11;TIEG TIEG1;BIGH3
460	CRB1-MPP5- PATJ complex	Human	CRB1-MPP5-INADL complex	MDCK cells	P82279;Q8N3R9;Q8NI35	23418;64398;10207	MI:0019-coimmunoprecipitation	GO:0051211;GO:0009798;GO:0007043;GO:0030054	anisotropic cell growth;axis specification;cell-cell junction assembly;cell junction	40.01.03;41.05.19;42.06.04;70.06	directional cell growth (morphogenesis);asymmetries and axis determination;intercellular junction (gap junction/adherens junction);cell junction	11927608	This complex  appears to be evolutionarily conserved and likely plays an important role in protein targeting and cell polarity.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein crumbs homolog 1;Protein PALS1;InaD-like protein	CRB1;PALS1;PATJ	None;MPP5;CIPP INADL
461	CRB1-MPP4-MPP5 complex	Human	None	eye	P82279;Q8N3R9;Q96JB8	23418;64398;58538	MI:0019-coimmunoprecipitation	GO:0009583;GO:0009416;GO:0007601	detection of light stimulus;response to light stimulus;visual perception	34.11.01;34.11.01.03	photoperception and response;visual transduction	15914641	This complex is localized in outer limiting membrane.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein crumbs homolog 1;Protein PALS1;MAGUK p55 subfamily member 4	CRB1;PALS1;MPP4	None;MPP5;ALS2CR5 DLG6
462	TFTC complex (TATA-binding protein-free TAF-II-containing complex)	Human	None	HeLa cells	O00268;O15265;O75486;O75528;O75529;P49848;Q12962;Q15393;Q15542;Q15545;Q16514;Q16594;Q6P1X5;Q92830;Q9Y4A5;Q9Y6J9	6874;6314;8464;10474;27097;6878;6881;23450;6877;6879;6883;6880;6873;2648;8295;10629	MI:0004-affinity chromatography technology;MI:0006-anti bait coimmunoprecipitation;MI:0071-molecular sieving	GO:0006265;GO:0006352;GO:0045893;GO:0051276;GO:0005634;GO:0016573	DNA topological change;DNA-templated transcription initiation;positive regulation of DNA-templated transcription;chromosome organization;nucleus;histone acetylation	10.01.09.05;11.02.03.01.01;11.02.03.04.01;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription initiation;transcription activation;organization of chromosome structure;nucleus	9603525	TFTC complex can replace TFIID in vitro, indicating that multiple preinitiation complexes may play an important role in regulating gene expression.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transcription initiation factor TFIID subunit 4;Ataxin-7;Transcription initiation protein SPT3 homolog;Transcriptional adapter 3;TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L;Transcription initiation factor TFIID subunit 6;Transcription initiation factor TFIID subunit 10;Splicing factor 3B subunit 3;Transcription initiation factor TFIID subunit 5;Transcription initiation factor TFIID subunit 7;Transcription initiation factor TFIID subunit 12;Transcription initiation factor TFIID subunit 9;Transcription initiation factor TFIID subunit 2;Histone acetyltransferase KAT2A;Transformation/transcription domain-associated protein;TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L	TAF4;ATXN7;SUPT3H;TADA3;TAF5L;TAF6;TAF10;SF3B3;TAF5;TAF7;TAF12;TAF9;TAF2;KAT2A;TRRAP;TAF6L	TAF2C TAF2C1 TAF4A TAFII130 TAFII135;SCA7;SPT3;ADA3 TADA3L;PAF65B;TAF2E TAFII70;TAF2A TAF2H TAFII30;KIAA0017 SAP130;TAF2D;TAF2F TAFII55;TAF15 TAF2J TAFII20;TAF2G TAFII31;CIF150 TAF2B;GCN5 GCN5L2;PAF400;PAF65A
463	TFIID complex	Human	TFIID(beta) transcription factor complex	HeLa cells	O00268;P20226;P21675;P49848;Q12962;Q15542;Q15543;Q15544;Q15545;Q16514;Q16594	6874;6908;6872;6878;6881;6877;6884;6882;6879;6883;6880	MI:0004-affinity chromatography technology;MI:0006-anti bait coimmunoprecipitation;MI:0071-molecular sieving	GO:0006352;GO:0006355;GO:0003677;GO:0005634	DNA-templated transcription initiation;regulation of DNA-templated transcription;DNA binding;nucleus	11.02.03.01.01;11.02.03.04;16.03.01;70.10	transcription initiation;transcriptional control;DNA binding;nucleus	9603525	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transcription initiation factor TFIID subunit 4;TATA-box-binding protein;Transcription initiation factor TFIID subunit 1;Transcription initiation factor TFIID subunit 6;Transcription initiation factor TFIID subunit 10;Transcription initiation factor TFIID subunit 5;Transcription initiation factor TFIID subunit 13;Transcription initiation factor TFIID subunit 11;Transcription initiation factor TFIID subunit 7;Transcription initiation factor TFIID subunit 12;Transcription initiation factor TFIID subunit 9	TAF4;TBP;TAF1;TAF6;TAF10;TAF5;TAF13;TAF11;TAF7;TAF12;TAF9	TAF2C TAF2C1 TAF4A TAFII130 TAFII135;GTF2D1 TF2D TFIID;BA2R CCG1 CCGS TAF2A;TAF2E TAFII70;TAF2A TAF2H TAFII30;TAF2D;TAF2K TAFII18;TAF2I;TAF2F TAFII55;TAF15 TAF2J TAFII20;TAF2G TAFII31
466	Gamma-secretase complex (APH1A, PSEN1, PSENEN, NCSTN)	Human	Gamma-secretase complex	None	P49768;Q92542;Q96BI3;Q9NZ42	5663;23385;51107;55851	MI:0019-coimmunoprecipitation	GO:0016485;GO:0007219;GO:0005886;GO:0005794	protein processing;Notch signaling pathway;plasma membrane;Golgi apparatus	14.07.11;30.05.02.14;70.02;70.08	protein processing (proteolytic);Notch-receptor signalling pathway;eukaryotic plasma membrane / membrane attached;Golgi	15286082	Proteolytic cleavage within the hydrophobic transmembrane domains of Notch and APP are intimately associated with a multimeric gamma-secretase complex that contains the presenilin-1 or presenilin-2 and the membrane glycoprotein nicastrin. Three variants of APH1 (APH1A short, APH1A long and APH1B) as well as two presenillin variants (PSEN1 and PSEN2) allow the formation of six different gamma-secretase complexes.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Presenilin-1;Nicastrin;Gamma-secretase subunit APH-1A;Gamma-secretase subunit PEN-2	PSEN1;NCSTN;APH1A;PSENEN	AD3 PS1 PSNL1;KIAA0253;PSF;PEN2
467	Gamma-secretase complex (APH1B, PSEN2, PSENEN, NCSTN)	Human	None	None	P49810;Q8WW43;Q92542;Q9NZ42	5664;83464;23385;55851	MI:0019-coimmunoprecipitation	GO:0016485;GO:0051090;GO:0023052;GO:0007219;GO:0005886;GO:0005794	protein processing;regulation of DNA-binding transcription factor activity;signaling;Notch signaling pathway;plasma membrane;Golgi apparatus	14.07.11;18.02.09;30.01;30.05.02.14;70.02;70.08	protein processing (proteolytic);regulator of transcription factor;cellular signalling;Notch-receptor signalling pathway;eukaryotic plasma membrane / membrane attached;Golgi	15286082	Proteolytic cleavage within the hydrophobic transmembrane domains of Notch and APP are intimately associated with a multimeric gamma-secretase complex that contains the presenilin-1 or presenilin-2 and the membrane glycoprotein nicastrin. Three variants of APH1 (APH1A short, APH1A long and APH1B) as well as two presenilin variants (PSEN1 and PSEN2) allow the formation of six different gamma-secretase complexes.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Presenilin-2;Gamma-secretase subunit APH-1B;Nicastrin;Gamma-secretase subunit PEN-2	PSEN2;APH1B;NCSTN;PSENEN	AD4 PS2 PSNL2 STM2;PSFL;KIAA0253;PEN2
468	Gamma-secretase complex (APH1A, PSEN2, PSENEN, NCSTN)	Human	None	None	P49810;Q92542;Q96BI3;Q9NZ42	5664;23385;51107;55851	MI:0019-coimmunoprecipitation	GO:0016485;GO:0051090;GO:0023052;GO:0007219;GO:0005886;GO:0005794	protein processing;regulation of DNA-binding transcription factor activity;signaling;Notch signaling pathway;plasma membrane;Golgi apparatus	14.07.11;18.02.09;30.01;30.05.02.14;70.02;70.08	protein processing (proteolytic);regulator of transcription factor;cellular signalling;Notch-receptor signalling pathway;eukaryotic plasma membrane / membrane attached;Golgi	15286082	Proteolytic cleavage within the hydrophobic transmembrane domains of Notch and APP are intimately associated with a multimeric gamma-secretase complex that contains the presenilin-1 or presenilin-2 and the membrane glycoprotein nicastrin. Three variants of APH1 (APH1A short, APH1A long and APH1B) as well as two presenillin variants (PSEN1 and PSEN2) allow the formation of six different gamma-secretase complexes.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Presenilin-2;Nicastrin;Gamma-secretase subunit APH-1A;Gamma-secretase subunit PEN-2	PSEN2;NCSTN;APH1A;PSENEN	AD4 PS2 PSNL2 STM2;KIAA0253;PSF;PEN2
469	TFIID-beta complex	Human	TFIID(beta) transcription factor complex	None	O00268;P20226;P21675;P49848;Q12962;Q15542;Q15543;Q15544;Q15545;Q16514;Q16594;Q6P1X5	6874;6908;6872;6878;6881;6877;6884;6882;6879;6883;6880;6873	MI:0004-affinity chromatography technology;MI:0006-anti bait coimmunoprecipitation;MI:0040-electron microscopy;MI:0428-imaging technique	GO:0006352;GO:2001141;GO:0006355;GO:0005634	DNA-templated transcription initiation;regulation of RNA biosynthetic process;regulation of DNA-templated transcription;nucleus	11.02.03.01.01;11.02.03.04;70.10	transcription initiation;transcriptional control;nucleus	10591645	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transcription initiation factor TFIID subunit 4;TATA-box-binding protein;Transcription initiation factor TFIID subunit 1;Transcription initiation factor TFIID subunit 6;Transcription initiation factor TFIID subunit 10;Transcription initiation factor TFIID subunit 5;Transcription initiation factor TFIID subunit 13;Transcription initiation factor TFIID subunit 11;Transcription initiation factor TFIID subunit 7;Transcription initiation factor TFIID subunit 12;Transcription initiation factor TFIID subunit 9;Transcription initiation factor TFIID subunit 2	TAF4;TBP;TAF1;TAF6;TAF10;TAF5;TAF13;TAF11;TAF7;TAF12;TAF9;TAF2	TAF2C TAF2C1 TAF4A TAFII130 TAFII135;GTF2D1 TF2D TFIID;BA2R CCG1 CCGS TAF2A;TAF2E TAFII70;TAF2A TAF2H TAFII30;TAF2D;TAF2K TAFII18;TAF2I;TAF2F TAFII55;TAF15 TAF2J TAFII20;TAF2G TAFII31;CIF150 TAF2B
470	TFTC complex (TATA-binding protein-free TAF-II-containing complex)	Human	None	None	O00268;O15265;O75486;O75528;O75529;P49848;Q12962;Q15393;Q15542;Q15543;Q15545;Q16514;Q16594;Q6P1X5;Q92830;Q9Y4A5;Q9Y6J9	6874;6314;8464;10474;27097;6878;6881;23450;6877;6884;6879;6883;6880;6873;2648;8295;10629	MI:0004-affinity chromatography technology;MI:0006-anti bait coimmunoprecipitation;MI:0040-electron microscopy;MI:0428-imaging technique	GO:0006265;GO:0006352;GO:0045893;GO:0051276;GO:0005634;GO:0016573	DNA topological change;DNA-templated transcription initiation;positive regulation of DNA-templated transcription;chromosome organization;nucleus;histone acetylation	10.01.09.05;11.02.03.01.01;11.02.03.04.01;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription initiation;transcription activation;organization of chromosome structure;nucleus	10591645	None	None	Three other subunits of the complex were found in the analysis, which have not been further characterized. In following publications these proteins were identified as ataxin-7, splicing factor 3B subunit 3 and PAF65A.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transcription initiation factor TFIID subunit 4;Ataxin-7;Transcription initiation protein SPT3 homolog;Transcriptional adapter 3;TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L;Transcription initiation factor TFIID subunit 6;Transcription initiation factor TFIID subunit 10;Splicing factor 3B subunit 3;Transcription initiation factor TFIID subunit 5;Transcription initiation factor TFIID subunit 13;Transcription initiation factor TFIID subunit 7;Transcription initiation factor TFIID subunit 12;Transcription initiation factor TFIID subunit 9;Transcription initiation factor TFIID subunit 2;Histone acetyltransferase KAT2A;Transformation/transcription domain-associated protein;TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L	TAF4;ATXN7;SUPT3H;TADA3;TAF5L;TAF6;TAF10;SF3B3;TAF5;TAF13;TAF7;TAF12;TAF9;TAF2;KAT2A;TRRAP;TAF6L	TAF2C TAF2C1 TAF4A TAFII130 TAFII135;SCA7;SPT3;ADA3 TADA3L;PAF65B;TAF2E TAFII70;TAF2A TAF2H TAFII30;KIAA0017 SAP130;TAF2D;TAF2K TAFII18;TAF2F TAFII55;TAF15 TAF2J TAFII20;TAF2G TAFII31;CIF150 TAF2B;GCN5 GCN5L2;PAF400;PAF65A
471	PCAF complex	Human	PCAF histone acetylase-associated complex	HeLa cells	O75478;O75486;O75528;O75529;Q12962;Q16514;Q16594;Q92831;Q9Y4A5;Q9Y6J9	6871;8464;10474;27097;6881;6883;6880;8850;8295;10629	MI:0004-affinity chromatography technology;MI:0006-anti bait coimmunoprecipitation	GO:0006265;GO:0006351;GO:2001141;GO:0006355;GO:0006473;GO:0051276;GO:0005634	DNA topological change;DNA-templated transcription;regulation of RNA biosynthetic process;regulation of DNA-templated transcription;protein acetylation;chromosome organization;nucleus	10.01.09.05;11;11.02.03.04;14.07.04;42.10.03;70.10	DNA conformation modification (e.g. chromatin);TRANSCRIPTION;transcriptional control;modification by acetylation, deacetylation;organization of chromosome structure;nucleus	9674425	None	None	PCAF is a complex consisting of more than 20 different proteins. Several proteins have not been characterized in this study.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transcriptional adapter 2-alpha;Transcription initiation protein SPT3 homolog;Transcriptional adapter 3;TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L;Transcription initiation factor TFIID subunit 10;Transcription initiation factor TFIID subunit 12;Transcription initiation factor TFIID subunit 9;Histone acetyltransferase KAT2B;Transformation/transcription domain-associated protein;TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L	TADA2A;SUPT3H;TADA3;TAF5L;TAF10;TAF12;TAF9;KAT2B;TRRAP;TAF6L	TADA2L;SPT3;ADA3 TADA3L;PAF65B;TAF2A TAF2H TAFII30;TAF15 TAF2J TAFII20;TAF2G TAFII31;PCAF;PAF400;PAF65A
472	Prolyl 4-hydroxylase (alpha(I)-type)	Human	None	in vitro	P07237;P13674	5034;5033	MI:0027-cosedimentation	GO:0018126;GO:0006479;GO:0005515;GO:0005783	protein hydroxylation;protein methylation;protein binding;endoplasmic reticulum	14.07.09;16.01;70.07	posttranslational modification of amino acids (e.g. hydroxylation, methylation);protein binding;endoplasmic reticulum	7753822	Prolyl 4-hydroxylase (EC 1.14.11.2) catalyzes the formation of 4-hydroxyproline in collagens and related proteins.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Protein disulfide-isomerase;Prolyl 4-hydroxylase subunit alpha-1	P4HB;P4HA1	ERBA2L PDI PDIA1 PO4DB;P4HA
474	Prolyl 4-hydroxylase (alpha(III)-type)	Human	None	HEK293 cells	P07237;Q7Z4N8	5034;283208	MI:0027-cosedimentation	GO:0018126;GO:0006479;GO:0005515;GO:0005783	protein hydroxylation;protein methylation;protein binding;endoplasmic reticulum	14.07.09;16.01;70.07	posttranslational modification of amino acids (e.g. hydroxylation, methylation);protein binding;endoplasmic reticulum	14500733	Prolyl 4-hydroxylase (EC 1.14.11.2) catalyzes the formation of 4-hydroxyproline in collagens and related proteins.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Protein disulfide-isomerase;Prolyl 4-hydroxylase subunit alpha-3	P4HB;P4HA3	ERBA2L PDI PDIA1 PO4DB;None
475	STAGA complex	Human	STAGA coactivator complex; SPT3-TAF9-GCN5 acetyltransferase complex	None	O75486;O75528;O75529;O94864;Q12962;Q15393;Q16514;Q16594;Q92830;Q96BN2;Q9Y4A5;Q9Y6J9	8464;10474;27097;9913;6881;23450;6883;6880;2648;117143;8295;10629	MI:0004-affinity chromatography technology;MI:0007-anti tag coimmunoprecipitation	GO:0006265;GO:0045893;GO:0006974;GO:0051276;GO:0005634;GO:0016573	DNA topological change;positive regulation of DNA-templated transcription;cellular response to DNA damage stimulus;chromosome organization;nucleus;histone acetylation	10.01.09.05;11.02.03.04.01;32.01.09;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription activation;DNA damage response;organization of chromosome structure;nucleus	11564863	None	None	Three other subunits of the complex were found in the analysis, which have not been further characterized: STAF60, STAF55, STAF46.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transcription initiation protein SPT3 homolog;Transcriptional adapter 3;TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L;STAGA complex 65 subunit gamma;Transcription initiation factor TFIID subunit 10;Splicing factor 3B subunit 3;Transcription initiation factor TFIID subunit 12;Transcription initiation factor TFIID subunit 9;Histone acetyltransferase KAT2A;Transcriptional adapter 1;Transformation/transcription domain-associated protein;TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L	SUPT3H;TADA3;TAF5L;SUPT7L;TAF10;SF3B3;TAF12;TAF9;KAT2A;TADA1;TRRAP;TAF6L	SPT3;ADA3 TADA3L;PAF65B;KIAA0764;TAF2A TAF2H TAFII30;KIAA0017 SAP130;TAF15 TAF2J TAFII20;TAF2G TAFII31;GCN5 GCN5L2;TADA1L;PAF400;PAF65A
476	STAGA complex	Human	STAGA coactivator complex; SPT3-TAF9-GCN5 acetyltransferase complex	None	O15265;O75486;O75528;O75529;O94864;Q12962;Q15393;Q16514;Q16594;Q92830;Q96BN2;Q9Y4A5;Q9Y6J9	6314;8464;10474;27097;9913;6881;23450;6883;6880;2648;117143;8295;10629	MI:0006-anti bait coimmunoprecipitation	GO:0006265;GO:0045893;GO:0006974;GO:0051276;GO:0005634;GO:0016573	DNA topological change;positive regulation of DNA-templated transcription;cellular response to DNA damage stimulus;chromosome organization;nucleus;histone acetylation	10.01.09.05;11.02.03.04.01;32.01.09;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription activation;DNA damage response;organization of chromosome structure;nucleus	15115762	This complex is a coactivator required for transcription of a subset of RNA polymerase II-dependent genes.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Ataxin-7;Transcription initiation protein SPT3 homolog;Transcriptional adapter 3;TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L;STAGA complex 65 subunit gamma;Transcription initiation factor TFIID subunit 10;Splicing factor 3B subunit 3;Transcription initiation factor TFIID subunit 12;Transcription initiation factor TFIID subunit 9;Histone acetyltransferase KAT2A;Transcriptional adapter 1;Transformation/transcription domain-associated protein;TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L	ATXN7;SUPT3H;TADA3;TAF5L;SUPT7L;TAF10;SF3B3;TAF12;TAF9;KAT2A;TADA1;TRRAP;TAF6L	SCA7;SPT3;ADA3 TADA3L;PAF65B;KIAA0764;TAF2A TAF2H TAFII30;KIAA0017 SAP130;TAF15 TAF2J TAFII20;TAF2G TAFII31;GCN5 GCN5L2;TADA1L;PAF400;PAF65A
478	STAGA core complex	Human	SPT3-TAF9-GCN5 acetyltransferase complex	None	O75486;Q16594;Q92830	8464;6880;2648	MI:0007-anti tag coimmunoprecipitation	GO:0006265;GO:0045893;GO:0051276;GO:0005634;GO:0016573	DNA topological change;positive regulation of DNA-templated transcription;chromosome organization;nucleus;histone acetylation	10.01.09.05;11.02.03.04.01;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription activation;organization of chromosome structure;nucleus	9726987	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transcription initiation protein SPT3 homolog;Transcription initiation factor TFIID subunit 9;Histone acetyltransferase KAT2A	SUPT3H;TAF9;KAT2A	SPT3;TAF2G TAFII31;GCN5 GCN5L2
485	TFIID complex, B-cell specific	Human	None	Daudi cells	O00268;P20226;P21675;P49848;Q12962;Q15542;Q15543;Q15544;Q15545;Q16514;Q16594;Q92750	6874;6908;6872;6878;6881;6877;6884;6882;6879;6883;6880;6875	MI:0004-affinity chromatography technology	GO:0006352;GO:2001141;GO:0006355;GO:0003677;GO:0005634	DNA-templated transcription initiation;regulation of RNA biosynthetic process;regulation of DNA-templated transcription;DNA binding;nucleus	11.02.03.01.01;11.02.03.04;16.03.01;70.10	transcription initiation;transcriptional control;DNA binding;nucleus	8858156	TAF-II-105 (TAF4B) is a cell-type specific subunit of TFIID complex. Up to now TAF-II-105 is only found in differentiated B cells.Isolation of TBP and TAF9-TAF13 was not shown in this paper.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transcription initiation factor TFIID subunit 4;TATA-box-binding protein;Transcription initiation factor TFIID subunit 1;Transcription initiation factor TFIID subunit 6;Transcription initiation factor TFIID subunit 10;Transcription initiation factor TFIID subunit 5;Transcription initiation factor TFIID subunit 13;Transcription initiation factor TFIID subunit 11;Transcription initiation factor TFIID subunit 7;Transcription initiation factor TFIID subunit 12;Transcription initiation factor TFIID subunit 9;Transcription initiation factor TFIID subunit 4B	TAF4;TBP;TAF1;TAF6;TAF10;TAF5;TAF13;TAF11;TAF7;TAF12;TAF9;TAF4B	TAF2C TAF2C1 TAF4A TAFII130 TAFII135;GTF2D1 TF2D TFIID;BA2R CCG1 CCGS TAF2A;TAF2E TAFII70;TAF2A TAF2H TAFII30;TAF2D;TAF2K TAFII18;TAF2I;TAF2F TAFII55;TAF15 TAF2J TAFII20;TAF2G TAFII31;TAF2C2 TAFII105
486	WIP-WASp-actin-myosin-IIa complex	Human	None	NK cells	O43516;P19105;P35579;P42768;P60660;P62736	7456;10627;4627;7454;4637;59	MI:0019-coimmunoprecipitation	GO:0050896;GO:0030036;GO:0005856	response to stimulus;actin cytoskeleton organization;cytoskeleton	36.25;42.04.03;70.04	animal specific systemic sensing and response;actin cytoskeleton;cytoskeleton	16606694	The multiprotein complex is important for NK cell function. Killer cell immunoglobulin-like receptor inhibitory signaling affects proteins involved in cytoskeletal rearrangements. WIP plays a central role in the formation of the complex and in the regulation of NK cell activity.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	WAS/WASL-interacting protein family member 1;Myosin regulatory light chain 12A;Myosin-9;Actin nucleation-promoting factor WAS;Myosin light polypeptide 6;Actin, aortic smooth muscle	WIPF1;MYL12A;MYH9;WAS;MYL6;ACTA2	WASPIP WIP;MLCB MRLC3 RLC;None;IMD2;None;ACTSA ACTVS
490	TFIIA complex	Human	None	HeLa cells	P52655;P52657	2957;2958	MI:0004-affinity chromatography technology	GO:0006352;GO:2001141;GO:0006355;GO:0005634	DNA-templated transcription initiation;regulation of RNA biosynthetic process;regulation of DNA-templated transcription;nucleus	11.02.03.01.01;11.02.03.04;70.10	transcription initiation;transcriptional control;nucleus	2247058	TFIIA is a heterotrimer of an alpha (p35), a beta (p19) and a gamma subunit (p12).	None	GTF2A1 encodes both the alpha and beta subunits. (PMID: 8224848)	Homo sapiens (Human);Homo sapiens (Human)	Transcription initiation factor IIA subunit 1;Transcription initiation factor IIA subunit 2	GTF2A1;GTF2A2	TF2A1;TF2A2
492	DA complex	Human	TFIID-TFIIA complex	None	O00268;P20226;P21675;P49848;P52655;P52657;Q12962;Q15542;Q15543;Q15544;Q15545;Q16514;Q16594;Q5VWG9;Q6P1X5	6874;6908;6872;6878;2957;2958;6881;6877;6884;6882;6879;6883;6880;83860;6873	MI:0091-chromatography technology	GO:0006352;GO:2001141;GO:0006355;GO:0003677;GO:0005634	DNA-templated transcription initiation;regulation of RNA biosynthetic process;regulation of DNA-templated transcription;DNA binding;nucleus	11.02.03.01.01;11.02.03.04;16.03.01;70.10	transcription initiation;transcriptional control;DNA binding;nucleus	2247058	DA is a multiprotein complex consisting of TFIID complex and TFIIA complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transcription initiation factor TFIID subunit 4;TATA-box-binding protein;Transcription initiation factor TFIID subunit 1;Transcription initiation factor TFIID subunit 6;Transcription initiation factor IIA subunit 1;Transcription initiation factor IIA subunit 2;Transcription initiation factor TFIID subunit 10;Transcription initiation factor TFIID subunit 5;Transcription initiation factor TFIID subunit 13;Transcription initiation factor TFIID subunit 11;Transcription initiation factor TFIID subunit 7;Transcription initiation factor TFIID subunit 12;Transcription initiation factor TFIID subunit 9;Transcription initiation factor TFIID subunit 3;Transcription initiation factor TFIID subunit 2	TAF4;TBP;TAF1;TAF6;GTF2A1;GTF2A2;TAF10;TAF5;TAF13;TAF11;TAF7;TAF12;TAF9;TAF3;TAF2	TAF2C TAF2C1 TAF4A TAFII130 TAFII135;GTF2D1 TF2D TFIID;BA2R CCG1 CCGS TAF2A;TAF2E TAFII70;TF2A1;TF2A2;TAF2A TAF2H TAFII30;TAF2D;TAF2K TAFII18;TAF2I;TAF2F TAFII55;TAF15 TAF2J TAFII20;TAF2G TAFII31;None;CIF150 TAF2B
493	DAB complex	Human	TFIID-TFIIA-TFIIB complex	None	O00268;P20226;P21675;P49848;P52655;P52657;Q00403;Q12962;Q15542;Q15543;Q15544;Q15545;Q16514;Q16594;Q5VWG9;Q6P1X5	6874;6908;6872;6878;2957;2958;2959;6881;6877;6884;6882;6879;6883;6880;83860;6873	MI:0091-chromatography technology	GO:0006352;GO:2001141;GO:0006355;GO:0003677;GO:0005634	DNA-templated transcription initiation;regulation of RNA biosynthetic process;regulation of DNA-templated transcription;DNA binding;nucleus	11.02.03.01.01;11.02.03.04;16.03.01;70.10	transcription initiation;transcriptional control;DNA binding;nucleus	2247058	DAB is a multiprotein complex consisting of TFIID complex, TFIIA complex and TFIIB.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transcription initiation factor TFIID subunit 4;TATA-box-binding protein;Transcription initiation factor TFIID subunit 1;Transcription initiation factor TFIID subunit 6;Transcription initiation factor IIA subunit 1;Transcription initiation factor IIA subunit 2;Transcription initiation factor IIB;Transcription initiation factor TFIID subunit 10;Transcription initiation factor TFIID subunit 5;Transcription initiation factor TFIID subunit 13;Transcription initiation factor TFIID subunit 11;Transcription initiation factor TFIID subunit 7;Transcription initiation factor TFIID subunit 12;Transcription initiation factor TFIID subunit 9;Transcription initiation factor TFIID subunit 3;Transcription initiation factor TFIID subunit 2	TAF4;TBP;TAF1;TAF6;GTF2A1;GTF2A2;GTF2B;TAF10;TAF5;TAF13;TAF11;TAF7;TAF12;TAF9;TAF3;TAF2	TAF2C TAF2C1 TAF4A TAFII130 TAFII135;GTF2D1 TF2D TFIID;BA2R CCG1 CCGS TAF2A;TAF2E TAFII70;TF2A1;TF2A2;TF2B TFIIB;TAF2A TAF2H TAFII30;TAF2D;TAF2K TAFII18;TAF2I;TAF2F TAFII55;TAF15 TAF2J TAFII20;TAF2G TAFII31;None;CIF150 TAF2B
497	TAF4-TAF12 subcomplex of TFIID complex	Human	None	None	O00268;Q16514	6874;6883	MI:0004-affinity chromatography technology;MI:0114-x-ray crystallography	GO:0006352;GO:2001141;GO:0006355;GO:0005515;GO:0005634	DNA-templated transcription initiation;regulation of RNA biosynthetic process;regulation of DNA-templated transcription;protein binding;nucleus	11.02.03.01.01;11.02.03.04;16.01;70.10	transcription initiation;transcriptional control;protein binding;nucleus	12237304	TAF12 forms a histone-like heterodimer with TAF4, rather than homodimerizing as suggested earlier (PMID:8598932).	None	None	Homo sapiens (Human);Homo sapiens (Human)	Transcription initiation factor TFIID subunit 4;Transcription initiation factor TFIID subunit 12	TAF4;TAF12	TAF2C TAF2C1 TAF4A TAFII130 TAFII135;TAF15 TAF2J TAFII20
499	RYK-WNT1 complex	Human	None	293T cells	P04628;P34925	7471;6259	MI:0019-coimmunoprecipitation	GO:0016055	Wnt signaling pathway	30.05.02.20	Wnt signalling pathway	15454084	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Proto-oncogene Wnt-1;Tyrosine-protein kinase RYK	WNT1;RYK	INT1;JTK5A
500	RYK-WNT3A complex	Human	None	293T cells	P34925;P56704	6259;89780	MI:0019-coimmunoprecipitation	GO:0016055	Wnt signaling pathway	30.05.02.20	Wnt signalling pathway	15454084	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Tyrosine-protein kinase RYK;Protein Wnt-3a	RYK;WNT3A	JTK5A;None
501	DVL1-RYK complex	Human	None	293T cells	O14640;P34925	1855;6259	MI:0019-coimmunoprecipitation	GO:0016055	Wnt signaling pathway	30.05.02.20	Wnt signalling pathway	15454084	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Segment polarity protein dishevelled homolog DVL-1;Tyrosine-protein kinase RYK	DVL1;RYK	None;JTK5A
508	TFIID complex	Human	None	None	O00268;P20226;P21675;P49848;Q12962;Q15542;Q15544;Q15545;Q16514;Q16594	6874;6908;6872;6878;6881;6877;6882;6879;6883;6880	MI:0006-anti bait coimmunoprecipitation	GO:0006352;GO:2001141;GO:0006355;GO:0003677;GO:0005634	DNA-templated transcription initiation;regulation of RNA biosynthetic process;regulation of DNA-templated transcription;DNA binding;nucleus	11.02.03.01.01;11.02.03.04;16.03.01;70.10	transcription initiation;transcriptional control;DNA binding;nucleus	8663456	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transcription initiation factor TFIID subunit 4;TATA-box-binding protein;Transcription initiation factor TFIID subunit 1;Transcription initiation factor TFIID subunit 6;Transcription initiation factor TFIID subunit 10;Transcription initiation factor TFIID subunit 5;Transcription initiation factor TFIID subunit 11;Transcription initiation factor TFIID subunit 7;Transcription initiation factor TFIID subunit 12;Transcription initiation factor TFIID subunit 9	TAF4;TBP;TAF1;TAF6;TAF10;TAF5;TAF11;TAF7;TAF12;TAF9	TAF2C TAF2C1 TAF4A TAFII130 TAFII135;GTF2D1 TF2D TFIID;BA2R CCG1 CCGS TAF2A;TAF2E TAFII70;TAF2A TAF2H TAFII30;TAF2D;TAF2I;TAF2F TAFII55;TAF15 TAF2J TAFII20;TAF2G TAFII31
509	TFIID complex	Human	None	None	O00268;P20226;P21675;P49848;Q12962;Q15542;Q15543;Q15544;Q15545;Q16514;Q16594;Q92804	6874;6908;6872;6878;6881;6877;6884;6882;6879;6883;6880;8148	MI:0006-anti bait coimmunoprecipitation	GO:0006352;GO:2001141;GO:0006355;GO:0003677;GO:0005634	DNA-templated transcription initiation;regulation of RNA biosynthetic process;regulation of DNA-templated transcription;DNA binding;nucleus	11.02.03.01.01;11.02.03.04;16.03.01;70.10	transcription initiation;transcriptional control;DNA binding;nucleus	8890175	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transcription initiation factor TFIID subunit 4;TATA-box-binding protein;Transcription initiation factor TFIID subunit 1;Transcription initiation factor TFIID subunit 6;Transcription initiation factor TFIID subunit 10;Transcription initiation factor TFIID subunit 5;Transcription initiation factor TFIID subunit 13;Transcription initiation factor TFIID subunit 11;Transcription initiation factor TFIID subunit 7;Transcription initiation factor TFIID subunit 12;Transcription initiation factor TFIID subunit 9;TATA-binding protein-associated factor 2N	TAF4;TBP;TAF1;TAF6;TAF10;TAF5;TAF13;TAF11;TAF7;TAF12;TAF9;TAF15	TAF2C TAF2C1 TAF4A TAFII130 TAFII135;GTF2D1 TF2D TFIID;BA2R CCG1 CCGS TAF2A;TAF2E TAFII70;TAF2A TAF2H TAFII30;TAF2D;TAF2K TAFII18;TAF2I;TAF2F TAFII55;TAF15 TAF2J TAFII20;TAF2G TAFII31;RBP56 TAF2N
513	TFTC complex (TATA-binding protein-free TAF-II-containing complex)	Human	None	None	O00268;O15265;O75486;O75528;O75529;P49848;Q12962;Q15393;Q15542;Q15545;Q16514;Q16594;Q6P1X5;Q92830;Q9HBM6;Q9Y4A5;Q9Y6J9	6874;6314;8464;10474;27097;6878;6881;23450;6877;6879;6883;6880;6873;2648;51616;8295;10629	MI:0004-affinity chromatography technology;MI:0006-anti bait coimmunoprecipitation;MI:0071-molecular sieving	GO:0006265;GO:0006352;GO:0045893;GO:0006473;GO:0051276;GO:0005634	DNA topological change;DNA-templated transcription initiation;positive regulation of DNA-templated transcription;protein acetylation;chromosome organization;nucleus	10.01.09.05;11.02.03.01.01;11.02.03.04.01;14.07.04;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription initiation;transcription activation;modification by acetylation, deacetylation;organization of chromosome structure;nucleus	15899866	Gene expression profiling revealed that Taf9 and Taf9b control the expression of different sets of genes.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transcription initiation factor TFIID subunit 4;Ataxin-7;Transcription initiation protein SPT3 homolog;Transcriptional adapter 3;TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L;Transcription initiation factor TFIID subunit 6;Transcription initiation factor TFIID subunit 10;Splicing factor 3B subunit 3;Transcription initiation factor TFIID subunit 5;Transcription initiation factor TFIID subunit 7;Transcription initiation factor TFIID subunit 12;Transcription initiation factor TFIID subunit 9;Transcription initiation factor TFIID subunit 2;Histone acetyltransferase KAT2A;Transcription initiation factor TFIID subunit 9B;Transformation/transcription domain-associated protein;TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L	TAF4;ATXN7;SUPT3H;TADA3;TAF5L;TAF6;TAF10;SF3B3;TAF5;TAF7;TAF12;TAF9;TAF2;KAT2A;TAF9B;TRRAP;TAF6L	TAF2C TAF2C1 TAF4A TAFII130 TAFII135;SCA7;SPT3;ADA3 TADA3L;PAF65B;TAF2E TAFII70;TAF2A TAF2H TAFII30;KIAA0017 SAP130;TAF2D;TAF2F TAFII55;TAF15 TAF2J TAFII20;TAF2G TAFII31;CIF150 TAF2B;GCN5 GCN5L2;TAF9L;PAF400;PAF65A
514	TFIID-beta complex	Human	None	None	O00268;P20226;P21675;P49848;Q12962;Q15542;Q15543;Q15544;Q15545;Q16514;Q16594;Q9HBM6	6874;6908;6872;6878;6881;6877;6884;6882;6879;6883;6880;51616	MI:0004-affinity chromatography technology;MI:0006-anti bait coimmunoprecipitation;MI:0071-molecular sieving	GO:0006352;GO:2001141;GO:0006355;GO:0003677;GO:0005634	DNA-templated transcription initiation;regulation of RNA biosynthetic process;regulation of DNA-templated transcription;DNA binding;nucleus	11.02.03.01.01;11.02.03.04;16.03.01;70.10	transcription initiation;transcriptional control;DNA binding;nucleus	15899866	Gene expression profiling revealed that Taf9 and Taf9b control the expression of different sets of genes.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transcription initiation factor TFIID subunit 4;TATA-box-binding protein;Transcription initiation factor TFIID subunit 1;Transcription initiation factor TFIID subunit 6;Transcription initiation factor TFIID subunit 10;Transcription initiation factor TFIID subunit 5;Transcription initiation factor TFIID subunit 13;Transcription initiation factor TFIID subunit 11;Transcription initiation factor TFIID subunit 7;Transcription initiation factor TFIID subunit 12;Transcription initiation factor TFIID subunit 9;Transcription initiation factor TFIID subunit 9B	TAF4;TBP;TAF1;TAF6;TAF10;TAF5;TAF13;TAF11;TAF7;TAF12;TAF9;TAF9B	TAF2C TAF2C1 TAF4A TAFII130 TAFII135;GTF2D1 TF2D TFIID;BA2R CCG1 CCGS TAF2A;TAF2E TAFII70;TAF2A TAF2H TAFII30;TAF2D;TAF2K TAFII18;TAF2I;TAF2F TAFII55;TAF15 TAF2J TAFII20;TAF2G TAFII31;TAF9L
517	AKAP5-PRKAR2A-PPP3CA complex	Human	CNA\u2013AKAP79\u2013PKA complex,	None	P13861;P24588;Q08209	5576;9495;5530	MI:0055-fluorescent resonance energy transfer	GO:0006605;GO:0015031;GO:0006468;GO:0006470;GO:0005886;GO:0005856;GO:0048167;GO:0019722	protein targeting;protein transport;protein phosphorylation;protein dephosphorylation;plasma membrane;cytoskeleton;regulation of synaptic plasticity;calcium-mediated signaling	14.04;20.01.10;14.07.03;70.02;70.04;30.01.09.03	protein targeting, sorting and translocation;protein transport;modification by phosphorylation, dephosphorylation, autophosphorylation;eukaryotic plasma membrane / membrane attached;cytoskeleton;Ca2+ mediated signal transduction	12507994	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	cAMP-dependent protein kinase type II-alpha regulatory subunit;A-kinase anchor protein 5;Protein phosphatase 3 catalytic subunit alpha	PRKAR2A;AKAP5;PPP3CA	PKR2, PRKAR2;AKAP79;CALNA CNA
518	AKAP250-PKA-PDE4D complex	Human	None	HEK293 cells	P17612;Q02952;Q08499	5566;9590;5144	MI:0019-coimmunoprecipitation;MI:0415-enzymatic study	GO:0006886;GO:0006605;GO:0008104;GO:0030234;GO:0050790;GO:0019933;GO:0005886	intracellular protein transport;protein targeting;protein localization;enzyme regulator activity;regulation of catalytic activity;cAMP-mediated signaling;plasma membrane	14.04;18.01.03;18.02.01;30.01.09.07;70.02	protein targeting, sorting and translocation;regulation by localization;enzymatic activity regulation / enzyme regulator;cAMP/cGMP mediated signal transduction;eukaryotic plasma membrane / membrane attached	16642035	PDE4D protein isoforms were specified as PDE4D5 and PDE4D3. The authors identified gravin as the AKAP responsible for the localized regulation of cAMP levels by PKA and PDE4 activity.	None	Since the authors did not specify PKA catalytic subunit, we used PRKACA.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	cAMP-dependent protein kinase catalytic subunit alpha;A-kinase anchor protein 12;cAMP-specific 3',5'-cyclic phosphodiesterase 4D	PRKACA;AKAP12;PDE4D	PKACA;AKAP250;DPDE3
519	AMY-1-S-AKAP84-RII-beta complex	Human	None	None	P31323;Q92667;Q99417	5577;8165;26292	MI:0019-coimmunoprecipitation	GO:0019933;GO:0007276;GO:0005739	cAMP-mediated signaling;gamete generation;mitochondrion	30.01.09.07;41.05.25;70.16	cAMP/cGMP mediated signal transduction;gametogenesis;mitochondrion	11483602	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	cAMP-dependent protein kinase type II-beta regulatory subunit;A-kinase anchor protein 1, mitochondrial;c-Myc-binding protein	PRKAR2B;AKAP1;MYCBP	None;AKAP149 PRKA1;AMY1
520	KCNQ1 macromolecular complex	Human	None	heart muscle	P13861;P17612;P51787;P62136;Q99996	5576;5566;3784;5499;10142	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0005216;GO:0019933;GO:0050896	ion channel activity;cAMP-mediated signaling;response to stimulus	20.03.01.01;30.01.09.07;36.25	ion channels;cAMP/cGMP mediated signal transduction;animal specific systemic sensing and response	11799244	This complex is required for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	cAMP-dependent protein kinase type II-alpha regulatory subunit;cAMP-dependent protein kinase catalytic subunit alpha;Potassium voltage-gated channel subfamily KQT member 1;Serine/threonine-protein phosphatase PP1-alpha catalytic subunit;A-kinase anchor protein 9	PRKAR2A;PRKACA;KCNQ1;PPP1CA;AKAP9	PKR2, PRKAR2;PKACA;KCNA8 KCNA9 KVLQT1;PPP1A;AKAP350 AKAP450 KIAA0803
521	Polycystin-1-E-cadherin-beta-catenin complex	Human	None	epithelium	P12830;P35222;P98161	999;1499;5310	MI:0019-coimmunoprecipitation	GO:0045216;GO:0007043;GO:0030855;GO:0002009;GO:0001822;GO:0005886;GO:0005737	cell-cell junction organization;cell-cell junction assembly;epithelial cell differentiation;morphogenesis of an epithelium;kidney development;plasma membrane;cytoplasm	42.06.04;45.03.09;47.03.07.01;70.02;70.03	intercellular junction (gap junction/adherens junction);epithelium;kidney;eukaryotic plasma membrane / membrane attached;cytoplasm	14718571	Complex is disrupted in ADPKD cells.	Polycystin-1-E-cadherin-beta-catenin complex is involved in autosomal dominant polycystic kidney disease (ADPKD). The authors suggest that the expression of mutant polycystin-1 in ADPKD cells, which fails to be cell surface-expressed and assemble into multiprotein complexes with E-cadherin, results in altered cell-cell adhesion and polycystin-1 signaling, thereby triggering dedifferentiation.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cadherin-1;Catenin beta-1;Polycystin-1	CDH1;CTNNB1;PKD1	CDHE UVO;CTNNB;None
522	Polycystin-1-E-cadherin-beta-catenin-Flotillin-2 complex	Human	None	kidney epithelium	P12830;P35222;P98161;Q14254	999;1499;5310;2319	MI:0019-coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0030301	cholesterol transport	None	None	16038619	The authors conclude that even though the large multiprotein complex formed by polycystin-1, E-cadherin, beta-catenin and flotillin-2 is not associated with typical lipid rafts, it contains cholesterol molecules that mediate interactions between complexed proteins and may represent a specific membrane domain organization.	PKD1 is involved in ADPKD (autosomal dominant polycystic kidney disease).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cadherin-1;Catenin beta-1;Polycystin-1;Flotillin-2	CDH1;CTNNB1;PKD1;FLOT2	CDHE UVO;CTNNB;None;ESA1 M17S1
525	TIP60 histone acetylase complex	Human	TIP60-HAT complex	HeLa cells	O96019;Q92993;Q9Y230;Q9Y265;Q9Y4A5	86;10524;10856;8607;8295	MI:0007-anti tag coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0006281;GO:0006915;GO:0003677	DNA repair;apoptotic process;DNA binding	10.01.05.01;40.10.02;16.03.01	DNA repair;apoptosis (type I programmed cell death);DNA binding	10966108	The TIP60 histone acetylase complex plays a role in DNA repair and apoptosis.	None	Additional unknown members of the TIP60 complex (p160, p150, p100, p70, p57, p40, p31, p29) have been isolated.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Actin-like protein 6A;Histone acetyltransferase KAT5;RuvB-like 2;RuvB-like 1;Transformation/transcription domain-associated protein	ACTL6A;KAT5;RUVBL2;RUVBL1;TRRAP	BAF53 BAF53A INO80K;HTATIP, TIP60;INO80J TIP48 TIP49B;INO80H NMP238 TIP49 TIP49A;PAF400
527	TRPC3-TRPC4 channel complex, redox-sensitive	Human	None	None	Q13507;Q9UBN4	7222;7223	MI:0019-coimmunoprecipitation;MI:0055-fluorescent resonance energy transfer	GO:0008324;GO:0006812;GO:0005216;GO:0000302;GO:0006979;GO:0005886	cation transmembrane transporter activity;cation transport;ion channel activity;response to reactive oxygen species;response to oxidative stress;plasma membrane	20.01.01.01;20.03.01.01;32.01.01;70.02	cation transport (H+, Na+, K+, Ca2+ , NH4+, etc.);ion channels;oxidative stress response;eukaryotic plasma membrane / membrane attached	16537542	Complex analysed in the HEK293 expression system. The authors propose TRPC3 and TRPC4 as subunits of native endothelial cation channels that are governed by the cellular redox state.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Short transient receptor potential channel 3;Short transient receptor potential channel 4	TRPC3;TRPC4	TRP3;None
528	NuA4/Tip60-HAT complex	Human	None	None	O95619;O96019;Q15014;Q92993;Q96L91;Q9H0E9;Q9H2F5;Q9HAF1;Q9NPF5;Q9NV56;Q9NXR8;Q9UBU8;Q9Y230;Q9Y265;Q9Y4A5	8089;86;9643;10524;57634;10902;80314;64769;55929;55257;54556;10933;10856;8607;8295	MI:0004-affinity chromatography technology	GO:0051276;GO:0006281;GO:0006265;GO:0003677;GO:0005634;GO:0016573	chromosome organization;DNA repair;DNA topological change;DNA binding;nucleus;histone acetylation	42.10.03;10.01.05.01;10.01.09.05;16.03.01;70.10	organization of chromosome structure;DNA repair;DNA conformation modification (e.g. chromatin);DNA binding;nucleus	12963728	The NuA4 histone acetyltransferase (HAT) multisubunit complex is responsible for acetylation of histone H4 and H2A N-terminal tails in yeast. The NuA4/Tip60 HAT complex is highly conserved in eukaryotes playing primary roles in transcription, cellular response to DNA damage, and cell cycle control.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	YEATS domain-containing protein 4;Actin-like protein 6A;Mortality factor 4-like protein 2;Histone acetyltransferase KAT5;E1A-binding protein p400;Bromodomain-containing protein 8;Enhancer of polycomb homolog 1;Chromatin modification-related protein MEAF6;DNA methyltransferase 1-associated protein 1;MRG/MORF4L-binding protein;Inhibitor of growth protein 3;Mortality factor 4-like protein 1;RuvB-like 2;RuvB-like 1;Transformation/transcription domain-associated protein	YEATS4;ACTL6A;MORF4L2;KAT5;EP400;BRD8;EPC1;MEAF6;DMAP1;MRGBP;ING3;MORF4L1;RUVBL2;RUVBL1;TRRAP	GAS41;BAF53 BAF53A INO80K;KIAA0026 MRGX;HTATIP, TIP60;CAGH32 KIAA1498 KIAA1818 TNRC12;SMAP, SMAP2;None;C1orf149 CENP-28 EAF6;KIAA1425;C20orf20;None;MRG15;INO80J TIP48 TIP49B;INO80H NMP238 TIP49 TIP49A;PAF400
529	NuA4/Tip60-HAT complex	Human	None	None	O95619;O96019;Q15014;Q15906;Q92993;Q96L91;Q9H0E9;Q9H2F5;Q9HAF1;Q9NPF5;Q9NV56;Q9NXR8;Q9UBU8;Q9Y230;Q9Y265;Q9Y4A5	8089;86;9643;6944;10524;57634;10902;80314;64769;55929;55257;54556;10933;10856;8607;8295	MI:0007-anti tag coimmunoprecipitation	GO:0051276;GO:0006281;GO:0006265;GO:0003677;GO:0005634;GO:0016573	chromosome organization;DNA repair;DNA topological change;DNA binding;nucleus;histone acetylation	42.10.03;10.01.05.01;10.01.09.05;16.03.01;70.10	organization of chromosome structure;DNA repair;DNA conformation modification (e.g. chromatin);DNA binding;nucleus	15647280	The NuA4 histone acetyltransferase (HAT) multisubunit complex is responsible for acetylation of histone H4 and H2A N-terminal tails in yeast. The NuA4/Tip60 HAT complex is highly conserved in eukaryotes playing primary roles in transcription, cellular response to DNA damage, and cell cycle control.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	YEATS domain-containing protein 4;Actin-like protein 6A;Mortality factor 4-like protein 2;Vacuolar protein sorting-associated protein 72 homolog;Histone acetyltransferase KAT5;E1A-binding protein p400;Bromodomain-containing protein 8;Enhancer of polycomb homolog 1;Chromatin modification-related protein MEAF6;DNA methyltransferase 1-associated protein 1;MRG/MORF4L-binding protein;Inhibitor of growth protein 3;Mortality factor 4-like protein 1;RuvB-like 2;RuvB-like 1;Transformation/transcription domain-associated protein	YEATS4;ACTL6A;MORF4L2;VPS72;KAT5;EP400;BRD8;EPC1;MEAF6;DMAP1;MRGBP;ING3;MORF4L1;RUVBL2;RUVBL1;TRRAP	GAS41;BAF53 BAF53A INO80K;KIAA0026 MRGX;TCFL1 YL1;HTATIP, TIP60;CAGH32 KIAA1498 KIAA1818 TNRC12;SMAP, SMAP2;None;C1orf149 CENP-28 EAF6;KIAA1425;C20orf20;None;MRG15;INO80J TIP48 TIP49B;INO80H NMP238 TIP49 TIP49A;PAF400
531	XPA-ERCC1-ERCC4 complex	Human	None	HeLacells	P07992;P23025;Q92889	2067;7507;2072	MI:0004-affinity chromatography technology	GO:0006281;GO:0006950;GO:0005634	DNA repair;response to stress;nucleus	10.01.05.01;32.01;70.10	DNA repair;stress response;nucleus	8197175	None	ERCC4 is involved in Xeroderma pigmentosum group F.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA excision repair protein ERCC-1;DNA repair protein complementing XP-A cells;DNA repair endonuclease XPF	ERCC1;XPA;ERCC4	None;XPAC;ERCC11 XPF
533	IMP3-IMP4-MPP10 complex	Human	None	Hep-2 cells	O00566;Q96G21;Q9NV31	10199;92856;55272	MI:0019-coimmunoprecipitation;MI:0029-cosedimentation through density gradient;MI:0096-pull down	GO:0005515;GO:0003723;GO:0005634;GO:0065003	protein binding;RNA binding;nucleus;protein-containing complex assembly	16.01;16.03.03;70.10	protein binding;RNA binding;nucleus	12655004	The formation of the hImp3-hMpp10-hImp4 complex correlates with the nucleolar localization of these proteins.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	U3 small nucleolar ribonucleoprotein protein MPP10;U3 small nucleolar ribonucleoprotein protein IMP4;U3 small nucleolar ribonucleoprotein protein IMP3	MPHOSPH10;IMP4;IMP3	MPP10;BXDC4;C15orf12 MRPS4
535	TRAP complex	Human	thyroid hormone receptor-associated protein complex	None	O60244;O75448;O75586;P10827;P24863;Q13503;Q15648;Q6P2C8;Q93074;Q9BTT4;Q9NPJ6;Q9NVC6;Q9UHV7;Q9Y2W1;Q9Y2X0;Q9Y3C7	9282;9862;10001;7067;892;9412;5469;9442;9968;84246;29079;9440;9969;9967;10025;51003	MI:0004-affinity chromatography technology	GO:2001141;GO:0006355;GO:0051090;GO:0009755;GO:0023052;GO:0005634	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;regulation of DNA-binding transcription factor activity;hormone-mediated signaling pathway;signaling;nucleus	11.02.03.04;18.02.09;30.01.09.08;30.01;70.10	transcriptional control;regulator of transcription factor;hormone mediated signal transduction;cellular signalling;nucleus	10198638	The human thyroid hormone receptor-associated protein (TRAP) complex is a coactivator for nuclear receptors.  Several identical subunits appear in protein complexes like DRIP/ARC, CRSP, NAT, PC2, SMCC and Mediator, indicating that unique classes of transcription activators may share common sets or subsets of cofactors.	None	Two, up to now uncharacterized members of the complex have been additionally isolated: TRAP97 and TRAP93.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mediator of RNA polymerase II transcription subunit 14;Mediator of RNA polymerase II transcription subunit 24;Mediator of RNA polymerase II transcription subunit 6;Thyroid hormone receptor alpha;Cyclin-C;Mediator of RNA polymerase II transcription subunit 21;Mediator of RNA polymerase II transcription subunit 1;Mediator of RNA polymerase II transcription subunit 27;Mediator of RNA polymerase II transcription subunit 12;Mediator of RNA polymerase II transcription subunit 10;Mediator of RNA polymerase II transcription subunit 4;Mediator of RNA polymerase II transcription subunit 17;Mediator of RNA polymerase II transcription subunit 13;Thyroid hormone receptor-associated protein 3;Mediator of RNA polymerase II transcription subunit 16;Mediator of RNA polymerase II transcription subunit 31	MED14;MED24;MED6;THRA;CCNC;MED21;MED1;MED27;MED12;MED10;MED4;MED17;MED13;THRAP3;MED16;MED31	ARC150 CRSP2 CXorf4 DRIP150 EXLM1 RGR1 TRAP170;ARC100 CRSP4 DRIP100 KIAA0130 THRAP4 TRAP100;ARC33;EAR7 ERBA1 NR1A1 THRA1 THRA2;None;SRB7 SURB7;ARC205 CRSP1 CRSP200 DRIP205 DRIP230 PBP PPARBP PPARGBP RB18A TRAP220 TRIP2;CRSP34 CRSP8;ARC240 CAGH45 HOPA KIAA0192 TNRC11 TRAP230;None;ARC36 DRIP36 VDRIP;ARC77 CRSP6 DRIP77 DRIP80 TRAP80;ARC250 KIAA0593 THRAP1 TRAP240;BCLAF2 TRAP150;DRIP92 THRAP5;SOH1
536	TRPC1-TRPC3-TRPC7 complex	Human	None	None	P48995;Q13507;Q9HCX4	7220;7222;57113	MI:0019-coimmunoprecipitation	GO:0008324;GO:0006812;GO:0015267;GO:0006875;GO:0005886	cation transmembrane transporter activity;cation transport;channel activity;cellular metal ion homeostasis;plasma membrane	20.01.01.01;20.03.01;34.01.01.01;70.02	cation transport (H+, Na+, K+, Ca2+ , NH4+, etc.);channel / pore class transport;homeostasis of metal ions (Na, K, Ca etc.);eukaryotic plasma membrane / membrane attached	15972814	The results indicate that endogenous TRPC1, TRPC3, and TRPC7 participate in forming heteromeric store-operated channels, whereas TRPC3 and TRPC7 can also participate in forming heteromeric receptor-operated channels.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Short transient receptor potential channel 1;Short transient receptor potential channel 3;Short transient receptor potential channel 7	TRPC1;TRPC3;TRPC7	TRP1;TRP3;TRP7
541	IGF1-IGFBP3-ALS complex	Human	None	maternal serum	P05019;P17936;P35858	3479;3486;3483	MI:0004-affinity chromatography technology	GO:0050896	response to stimulus	36.25	animal specific systemic sensing and response	9795367	Circulating levels of IGF-I, IGFBP-3 and ALS, and their degree of association in the ternary complex in the fetus increased with gestational age.	IGF1 is implicated in the pathophysiology of pre-eclampsia.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Insulin-like growth factor I;Insulin-like growth factor-binding protein 3;Insulin-like growth factor-binding protein complex acid labile subunit	IGF1;IGFBP3;IGFALS	IBP1;IBP3;ALS
547	SMCC complex	Human	SRB/MED-containing cofactor complex	None	O60244;O75448;O75586;P24863;P49336;Q13503;Q15648;Q6P2C8;Q93074;Q9NPJ6;Q9NVC6;Q9UHV7;Q9Y2W1;Q9Y2X0	9282;9862;10001;892;1024;9412;5469;9442;9968;29079;9440;9969;9967;10025	MI:0004-affinity chromatography technology	GO:2001141;GO:0006355;GO:0005515;GO:0051090;GO:0005634	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;protein binding;regulation of DNA-binding transcription factor activity;nucleus	11.02.03.04;16.01;18.02.09;70.10	transcriptional control;protein binding;regulator of transcription factor;nucleus	10198638	Several identical subunits appear in protein complexes like DRIP/ARC, CRSP, NAT, PC2, SMCC and Mediator, indicating that unique classes of transcription activators may share common sets or subsets of cofactors.	None	In SMCC two, up to now uncharacterized members of the complex have been additionally isolated: TRAP97 and TRAP93.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mediator of RNA polymerase II transcription subunit 14;Mediator of RNA polymerase II transcription subunit 24;Mediator of RNA polymerase II transcription subunit 6;Cyclin-C;Cyclin-dependent kinase 8;Mediator of RNA polymerase II transcription subunit 21;Mediator of RNA polymerase II transcription subunit 1;Mediator of RNA polymerase II transcription subunit 27;Mediator of RNA polymerase II transcription subunit 12;Mediator of RNA polymerase II transcription subunit 4;Mediator of RNA polymerase II transcription subunit 17;Mediator of RNA polymerase II transcription subunit 13;Thyroid hormone receptor-associated protein 3;Mediator of RNA polymerase II transcription subunit 16	MED14;MED24;MED6;CCNC;CDK8;MED21;MED1;MED27;MED12;MED4;MED17;MED13;THRAP3;MED16	ARC150 CRSP2 CXorf4 DRIP150 EXLM1 RGR1 TRAP170;ARC100 CRSP4 DRIP100 KIAA0130 THRAP4 TRAP100;ARC33;None;None;SRB7 SURB7;ARC205 CRSP1 CRSP200 DRIP205 DRIP230 PBP PPARBP PPARGBP RB18A TRAP220 TRIP2;CRSP34 CRSP8;ARC240 CAGH45 HOPA KIAA0192 TNRC11 TRAP230;ARC36 DRIP36 VDRIP;ARC77 CRSP6 DRIP77 DRIP80 TRAP80;ARC250 KIAA0593 THRAP1 TRAP240;BCLAF2 TRAP150;DRIP92 THRAP5
548	DRIP complex	Human	vitamine-D-receptor interacting protein complex	Namalwa B cells	O43513;O60244;O75448;O75586;O95402;P11473;P28702;Q15648;Q93074;Q9NPJ6;Q9NVC6;Q9UHV7;Q9ULK4;Q9Y2X0	9443;9282;9862;10001;9441;7421;6257;5469;9968;29079;9440;9969;9439;10025	MI:0004-affinity chromatography technology;MI:0047-far western blotting	GO:0045893;GO:0051090;GO:0009755;GO:0005634;GO:0016573	positive regulation of DNA-templated transcription;regulation of DNA-binding transcription factor activity;hormone-mediated signaling pathway;nucleus;histone acetylation	11.02.03.04.01;18.02.09;30.01.09.08;70.10	transcription activation;regulator of transcription factor;hormone mediated signal transduction;nucleus	9637681	Nuclear receptors such as the steroid and thyroid hormone and vitamins A and D receptors, are known to regulate transcription by binding their cognate lipophilic ligands and subsequently undergoing a conformational change that alters their ability to interact with coregulatory proteins. These coregulatory proteins typically consist of complexes like DRIP that either repress (corepressors) or activate (coactivators) transcription. Several identical subunits appear in protein complexes like DRIP/ARC, CRSP, NAT, PC2, SMCC and Mediator, indicating that unique classes of transcription activators may share common sets or subsets of cofactors.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mediator of RNA polymerase II transcription subunit 7;Mediator of RNA polymerase II transcription subunit 14;Mediator of RNA polymerase II transcription subunit 24;Mediator of RNA polymerase II transcription subunit 6;Mediator of RNA polymerase II transcription subunit 26;Vitamin D3 receptor;Retinoic acid receptor RXR-beta;Mediator of RNA polymerase II transcription subunit 1;Mediator of RNA polymerase II transcription subunit 12;Mediator of RNA polymerase II transcription subunit 4;Mediator of RNA polymerase II transcription subunit 17;Mediator of RNA polymerase II transcription subunit 13;Mediator of RNA polymerase II transcription subunit 23;Mediator of RNA polymerase II transcription subunit 16	MED7;MED14;MED24;MED6;MED26;VDR;RXRB;MED1;MED12;MED4;MED17;MED13;MED23;MED16	ARC34 CRSP9;ARC150 CRSP2 CXorf4 DRIP150 EXLM1 RGR1 TRAP170;ARC100 CRSP4 DRIP100 KIAA0130 THRAP4 TRAP100;ARC33;ARC70 CRSP7;NR1I1;NR2B2;ARC205 CRSP1 CRSP200 DRIP205 DRIP230 PBP PPARBP PPARGBP RB18A TRAP220 TRIP2;ARC240 CAGH45 HOPA KIAA0192 TNRC11 TRAP230;ARC36 DRIP36 VDRIP;ARC77 CRSP6 DRIP77 DRIP80 TRAP80;ARC250 KIAA0593 THRAP1 TRAP240;ARC130 CRSP3 DRIP130 KIAA1216 SUR2;DRIP92 THRAP5
550	NOS3-CAV1-NOSTRIN complex	Human	None	whole blood and lymph	P29474;Q03135;Q8IVI9	4846;857;115677	MI:0019-coimmunoprecipitation;MI:0663-confocal microscopy	GO:0006886;GO:0006605;GO:0015031;GO:0005886	intracellular protein transport;protein targeting;protein transport;plasma membrane	14.04;20.01.10;70.02	protein targeting, sorting and translocation;protein transport;eukaryotic plasma membrane / membrane attached	16807357	Translocation of endothelial nitric-oxide synthase involves a ternary complex with caveolin-1 and NOSTRIN.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Nitric oxide synthase, endothelial;Caveolin-1;Nostrin	NOS3;CAV1;NOSTRIN	None;CAV;None
551	core-histone (H2A/H2B/H3/H4)-TDIF2-TDT complex	Human	None	in vitro	P04053;P62805;P68431;Q16777;Q16778;Q5QJE6	1791;None;None;8338;8349;30836	MI:0019-coimmunoprecipitation	GO:0005634;GO:0006338;GO:0003677	nucleus;chromatin remodeling;DNA binding	70.10;16.03.01	nucleus;DNA binding	12786946	The authors propose a dual function for TdIF2 in the N region synthesis. One is the function as an inhibitor of TdT. The other is that of a chromatin remodeling protein.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA nucleotidylexotransferase;Histone H4;Histone H3.1;Histone H2A type 2-C;Histone H2B type 2-E;Deoxynucleotidyltransferase terminal-interacting protein 2	DNTT;H4C1;H3C1;H2AC20;H2BC21;DNTTIP2	TDT;H4/A H4FA HIST1H4A;H3FA,HIST1H3A;H2AFQ HIST2H2AC;H2BFQ HIST2H2BE;ERBP, TDIF2
552	IFNAR1-IFNAR2-IFNB1 complex	Human	IFN alpha receptor-IFN beta1 complex; Type I IFN receptor-IFN beta1 complex; Type I interferon receptor-Interferon beta1 complex; IFNAR1-IFNAR2-IFNB1 complex	in vitro	P01574;P17181;P48551	3456;3454;3455	MI:0030-cross-linking study;MI:0071-molecular sieving	GO:0060337;GO:0045087;GO:0019221;GO:0051607	type I interferon signaling pathway;innate immune response;cytokine-mediated signaling pathway;defense response to virus	36.25.16.01	innate immune response (invertebrates and vertebrates)	10493588	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Interferon beta;Interferon alpha/beta receptor 1;Interferon alpha/beta receptor 2	IFNB1;IFNAR1;IFNAR2	IFB IFNB;IFNAR;IFNABR IFNARB
553	RHOA-IP3R-TRPC1 complex	Human	None	None	P48995;P61586;Q14643	7220;387;3708	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0008324;GO:0006812;GO:0005216;GO:0006875;GO:0005886	cation transmembrane transporter activity;cation transport;ion channel activity;cellular metal ion homeostasis;plasma membrane	20.01.01.01;20.03.01.01;34.01.01.01;70.02	cation transport (H+, Na+, K+, Ca2+ , NH4+, etc.);ion channels;homeostasis of metal ions (Na, K, Ca etc.);eukaryotic plasma membrane / membrane attached	12766172	Cells were stimulated with thrombin. The authors showed that thrombin stimulation of endothelial cells induced translocation of Rho, and subsequent co-localization of Rho with TRPC1 and IP3R at the plasmalemma.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Short transient receptor potential channel 1;Transforming protein RhoA;Inositol 1,4,5-trisphosphate receptor type 1	TRPC1;RHOA;ITPR1	TRP1;ARH12 ARHA RHO12;INSP3R1
554	PBAF complex	Human	Polybromo- and BAF containing complex; SWI/SNF complex B	HeLa cells	O96019;P51532;Q12824;Q68CP9;Q86U86;Q8TAQ2;Q92922;Q92925;Q969G3;Q96GM5	86;6597;6598;196528;55193;6601;6599;6603;6605;6602	MI:0226-ion exchange chromatography	GO:0005634;GO:0051276;GO:0003677;GO:0006265;GO:0009755;GO:0045893	nucleus;chromosome organization;DNA binding;DNA topological change;hormone-mediated signaling pathway;positive regulation of DNA-templated transcription	70.10;42.10.03;16.03.01;10.01.09.05;30.01.09.08;11.02.03.04.01	nucleus;organization of chromosome structure;DNA binding;DNA conformation modification (e.g. chromatin);hormone mediated signal transduction;transcription activation	11780067	The chromatin-remodeling complex PBAF facilitates gene activation by assisting transcription machinery to gain access to targets on the chromosome.The authors mentioned actin and beta-tubulin as additional members of the PBAF complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Actin-like protein 6A;Transcription activator BRG1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1;AT-rich interactive domain-containing protein 2;Protein polybromo-1;SWI/SNF complex subunit SMARCC2;SWI/SNF complex subunit SMARCC1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1	ACTL6A;SMARCA4;SMARCB1;ARID2;PBRM1;SMARCC2;SMARCC1;SMARCD2;SMARCE1;SMARCD1	BAF53 BAF53A INO80K;BAF190A BRG1 SNF2B SNF2L4;BAF47, INI1, SNF5L1;BAF200 KIAA1557;BAF180 PB1;BAF170;BAF155;BAF60B;BAF57;BAF60A
555	BAF complex	Human	SWI/SNF-A complex	None	O14497;O96019;P51532;Q12824;Q8TAQ2;Q92922;Q92925;Q969G3;Q96GM5	8289;86;6597;6598;6601;6599;6603;6605;6602	MI:0226-ion exchange chromatography	GO:0006265;GO:0045893;GO:0003677;GO:0051276;GO:0005694	DNA topological change;positive regulation of DNA-templated transcription;DNA binding;chromosome organization;chromosome	10.01.09.05;11.02.03.04.01;16.03.01;42.10.03;70.10.03	DNA conformation modification (e.g. chromatin);transcription activation;DNA binding;organization of chromosome structure;chromosome	11780067	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	AT-rich interactive domain-containing protein 1A;Actin-like protein 6A;Transcription activator BRG1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1;SWI/SNF complex subunit SMARCC2;SWI/SNF complex subunit SMARCC1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1	ARID1A;ACTL6A;SMARCA4;SMARCB1;SMARCC2;SMARCC1;SMARCD2;SMARCE1;SMARCD1	BAF250 BAF250A C1orf4 OSA1 SMARCF1;BAF53 BAF53A INO80K;BAF190A BRG1 SNF2B SNF2L4;BAF47, INI1, SNF5L1;BAF170;BAF155;BAF60B;BAF57;BAF60A
556	PBAF complex, BAF200-specific	Human	Polybromo- and BAF containing complex (9 subunits); SWI/SNF complex B	HCC1143 cells	O96019;P51532;Q12824;Q68CP9;Q8TAQ2;Q92922;Q969G3;Q96GM5	86;6597;6598;196528;6601;6599;6605;6602	MI:0007-anti tag coimmunoprecipitation;MI:0071-molecular sieving	GO:0006265;GO:0045893;GO:0003677;GO:0009755;GO:0051276;GO:0005694;GO:0005634	DNA topological change;positive regulation of DNA-templated transcription;DNA binding;hormone-mediated signaling pathway;chromosome organization;chromosome;nucleus	10.01.09.05;11.02.03.04.01;16.03.01;30.01.09.08;42.10.03;70.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription activation;DNA binding;hormone mediated signal transduction;organization of chromosome structure;chromosome;nucleus	15985610	BAF200 forms a complex in the absence of BAF180 in HCC1143 cells. This PBAF compex has all the components as the PBAF from HeLa cells it lacks BAF180. Instead, it contains a novel, up to now uncharacterized polypeptide with similar molecular weight as BAF180.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Actin-like protein 6A;Transcription activator BRG1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1;AT-rich interactive domain-containing protein 2;SWI/SNF complex subunit SMARCC2;SWI/SNF complex subunit SMARCC1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1	ACTL6A;SMARCA4;SMARCB1;ARID2;SMARCC2;SMARCC1;SMARCE1;SMARCD1	BAF53 BAF53A INO80K;BAF190A BRG1 SNF2B SNF2L4;BAF47, INI1, SNF5L1;BAF200 KIAA1557;BAF170;BAF155;BAF57;BAF60A
557	TRP1-G alpha-11-IP3R3-CAV1 signaling complex	Human	None	None	P29992;P48995;Q03135;Q14573	2767;7220;857;3710	MI:0019-coimmunoprecipitation	GO:0008324;GO:0006812;GO:0005216;GO:0006875;GO:0005886	cation transmembrane transporter activity;cation transport;ion channel activity;cellular metal ion homeostasis;plasma membrane	20.01.01.01;20.03.01.01;34.01.01.01;70.02	cation transport (H+, Na+, K+, Ca2+ , NH4+, etc.);ion channels;homeostasis of metal ions (Na, K, Ca etc.);eukaryotic plasma membrane / membrane attached	10766822	The results demonstrate that caveolar microdomains provide a scaffold for  assembly of key Ca(2+) signaling proteins into a complex and  coordination of the molecular interactions leading to the activation of SOC (store-operated Ca(2+) influx).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein subunit alpha-11;Short transient receptor potential channel 1;Caveolin-1;Inositol 1,4,5-trisphosphate receptor type 3	GNA11;TRPC1;CAV1;ITPR3	GA11;TRP1;CAV;None
558	Channel complex TRPM6-TRPM7	Human	None	epithelium	Q96QT4;Q9BX84	54822;140803	MI:0055-fluorescent resonance energy transfer	GO:0008324;GO:0006812;GO:0005216;GO:0005886	cation transmembrane transporter activity;cation transport;ion channel activity;plasma membrane	20.01.01.01;20.03.01.01;70.02	cation transport (H+, Na+, K+, Ca2+ , NH4+, etc.);ion channels;eukaryotic plasma membrane / membrane attached	14976260	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Transient receptor potential cation channel subfamily M member 7;Transient receptor potential cation channel subfamily M member 6	TRPM7;TRPM6	CHAK1 LTRPC7;CHAK2
559	Decapping complex	Human	None	None	P26196;Q6P2E9;Q8IU60;Q96F86;Q9NPI6	1656;23644;167227;80153;55802	MI:0019-coimmunoprecipitation	GO:0043488;GO:0005737	regulation of mRNA stability;cytoplasm	11.04.03.11;70.03	control of mRNA stability;cytoplasm	16364915	Decapping is a key step in mRNA turnover. The decapping complex was found to be localized in cytoplasmic processing bodies (PBs), which are thought to be the sites of mRNA decay.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Probable ATP-dependent RNA helicase DDX6;Enhancer of mRNA-decapping protein 4;m7GpppN-mRNA hydrolase;Enhancer of mRNA-decapping protein 3;mRNA-decapping enzyme 1A	DDX6;EDC4;DCP2;EDC3;DCP1A	HLR2 RCK;HEDLS;NUDT20;LSM16 YJDC YJEFN2;SMIF
561	LSm1-7 complex	Human	None	None	O15116;P62310;P62312;Q9UK45;Q9Y333;Q9Y4Y9;Q9Y4Z0	27257;27258;11157;51690;57819;23658;25804	MI:0226-ion exchange chromatography	GO:0043488;GO:0003723;GO:0005737	regulation of mRNA stability;RNA binding;cytoplasm	11.04.03.11;16.03.03;70.03	control of mRNA stability;RNA binding;cytoplasm	15711010	The cytoplasmic LSm1-7 complex is involved in mRNA decay. The complex has been shown to accumulate in processing bodies (PBs). The LSm2-8 complex which differs in only one subunit from the LSm1-7 complex is involved in RNA splicing. In contrast to the LSM1-7 complex, recombinant LSm2-8 binds to U6 snRNA in vitro.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	U6 snRNA-associated Sm-like protein LSm1;U6 snRNA-associated Sm-like protein LSm3;U6 snRNA-associated Sm-like protein LSm6;U6 snRNA-associated Sm-like protein LSm7;U6 snRNA-associated Sm-like protein LSm2;U6 snRNA-associated Sm-like protein LSm5;U6 snRNA-associated Sm-like protein LSm4	LSM1;LSM3;LSM6;LSM7;LSM2;LSM5;LSM4	CASM;None;None;None;C6orf28 G7B;None;None
562	LSm2-8 complex	Human	None	None	O95777;P62310;P62312;Q9UK45;Q9Y333;Q9Y4Y9;Q9Y4Z0	51691;27258;11157;51690;57819;23658;25804	MI:0029-cosedimentation through density gradient;MI:0226-ion exchange chromatography	GO:0008380;GO:0003723;GO:0005737;GO:0005634	RNA splicing;RNA binding;cytoplasm;nucleus	11.04.03.01;16.03.03;70.03;70.10	splicing;RNA binding;cytoplasm;nucleus	10523320	The LSm2-8 complex which differs in only one subunit from the LSm1-7 complex is involved in RNA splicing. In contrast to the LSM1-7 complex, recombinant LSm2-8 binds to U6 snRNA in vitro.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	U6 snRNA-associated Sm-like protein LSm8;U6 snRNA-associated Sm-like protein LSm3;U6 snRNA-associated Sm-like protein LSm6;U6 snRNA-associated Sm-like protein LSm7;U6 snRNA-associated Sm-like protein LSm2;U6 snRNA-associated Sm-like protein LSm5;U6 snRNA-associated Sm-like protein LSm4	LSM8;LSM3;LSM6;LSM7;LSM2;LSM5;LSM4	None;None;None;None;C6orf28 G7B;None;None
563	F1F0-ATPase, mitochondrial	Human	F1F0-ATP synthase (EC 3.6.3.14), mitochondrial; Complex V; F1F0 ATPase	heart muscle	O75947;O75964;P00846;P03928;P05496;P06576;P18859;P24539;P25705;P30049;P36542;P48047;P56134;P56381;P56385;Q9UII2	10476;10632;4508;4509;516;506;522;515;498;513;509;539;9551;514;521;93974	MI:0019-coimmunoprecipitation;MI:0069-mass spectrometry studies of complexes	GO:0009060;GO:0022904;GO:0005743;GO:0006754;GO:0042776;GO:1904949	aerobic respiration;respiratory electron transport chain;mitochondrial inner membrane;ATP biosynthetic process;proton motive force-driven mitochondrial ATP synthesis;ATPase complex	02.13.03;02.11.07;20.01.15;70.16.05	aerobic respiration;regulation of electron transport and membrane-associated energy conservation;electron transport;mitochondrial inner membrane	12110673	F1F0 ATPase is the fifth complex in the respiratory chain. The mammalian complex V consists of 16 different subunits with alpha(3), beta(3), gamma, delta and epsilon comprising the F1 part and a, b, c, d, e, f, g, A6L,OSCP, and coupling factor 6 providing the F0 and stator. Also associated in the complex under some conditions is an intrinsic inhibitor protein IF1.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	ATP synthase subunit d, mitochondrial;ATP synthase subunit g, mitochondrial;ATP synthase subunit a;ATP synthase protein 8;ATP synthase F(0) complex subunit C1, mitochondrial;ATP synthase subunit beta, mitochondrial;ATP synthase-coupling factor 6, mitochondrial;ATP synthase F(0) complex subunit B1, mitochondrial;ATP synthase subunit alpha, mitochondrial;ATP synthase subunit delta, mitochondrial;ATP synthase subunit gamma, mitochondrial;ATP synthase subunit O, mitochondrial;ATP synthase subunit f, mitochondrial;ATP synthase subunit epsilon, mitochondrial;ATP synthase subunit e, mitochondrial;ATPase inhibitor, mitochondrial	ATP5PD;ATP5MG;MT-ATP6;MT-ATP8;ATP5MC1;ATP5F1B;ATP5PF;ATP5PB;ATP5F1A;ATP5F1D;ATP5F1C;ATP5PO;ATP5MF;ATP5F1E;ATP5ME;ATP5IF1	ATP5H;ATP5L;ATP6 ATPASE6 MTATP6;ATP8, ATPASE8, MTATP8;ATP5G1;ATP5B ATPMB ATPSB;ATP5A ATP5J ATPM;ATP5F1;ATP5A ATP5A1 ATP5AL2 ATPM;ATP5D;ATP5C ATP5C1 ATP5CL1;ATP5O ATPO;ATP5J2 ATP5JL;ATP5E;ATP5I ATP5K;ATPI ATPIF1
564	BAF complex	Human	SWI/SNF complex A	None	O14497;O96019;P51531;Q12824;Q8TAQ2;Q92922;Q969G3;Q96GM5	8289;86;6595;6598;6601;6599;6605;6602	MI:0004-affinity chromatography technology;MI:0226-ion exchange chromatography	GO:0006265;GO:0045893;GO:0003677;GO:0051276;GO:0005634	DNA topological change;positive regulation of DNA-templated transcription;DNA binding;chromosome organization;nucleus	10.01.09.05;11.02.03.04.01;16.03.01;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription activation;DNA binding;organization of chromosome structure;nucleus	8895581	None	None	Since the authors did not specify SMARCD and SMARCA, we used isoform SMARCD1 and SMARCA2. At the time of annotation, the additional member BAF110 of the protein complex was not found in the UniProt database.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	AT-rich interactive domain-containing protein 1A;Actin-like protein 6A;Probable global transcription activator SNF2L2;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1;SWI/SNF complex subunit SMARCC2;SWI/SNF complex subunit SMARCC1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1	ARID1A;ACTL6A;SMARCA2;SMARCB1;SMARCC2;SMARCC1;SMARCE1;SMARCD1	BAF250 BAF250A C1orf4 OSA1 SMARCF1;BAF53 BAF53A INO80K;BAF190B BRM SNF2A SNF2L2;BAF47, INI1, SNF5L1;BAF170;BAF155;BAF57;BAF60A
565	PBAF complex (Polybromo- and BAF containing complex)	Human	SWI/SNF complex B	YT cells	O96019;P51532;Q12824;Q68CP9;Q86U86;Q8TAQ2;Q92922;Q969G3;Q96GM5	86;6597;6598;196528;55193;6601;6599;6605;6602	MI:0004-affinity chromatography technology;MI:0226-ion exchange chromatography	GO:0006265;GO:0045893;GO:0003677;GO:0009755;GO:0051276;GO:0005694	DNA topological change;positive regulation of DNA-templated transcription;DNA binding;hormone-mediated signaling pathway;chromosome organization;chromosome	10.01.09.05;11.02.03.04.01;16.03.01;30.01.09.08;42.10.03;70.10.03	DNA conformation modification (e.g. chromatin);transcription activation;DNA binding;hormone mediated signal transduction;organization of chromosome structure;chromosome	8895581	The chromatin-remodeling complex PBAF facilitates gene activation by assisting transcription machinery to gain access to targets on the chromosome.	None	Since the authors did not specify SMARCD, we used isoform SMARCD1. At the time of annotation, the additional member BAF110 of the protein complex was not found in the UniProt database.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Actin-like protein 6A;Transcription activator BRG1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1;AT-rich interactive domain-containing protein 2;Protein polybromo-1;SWI/SNF complex subunit SMARCC2;SWI/SNF complex subunit SMARCC1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1	ACTL6A;SMARCA4;SMARCB1;ARID2;PBRM1;SMARCC2;SMARCC1;SMARCE1;SMARCD1	BAF53 BAF53A INO80K;BAF190A BRG1 SNF2B SNF2L4;BAF47, INI1, SNF5L1;BAF200 KIAA1557;BAF180 PB1;BAF170;BAF155;BAF57;BAF60A
566	BAF complex	Human	SWI/SNF complex A	None	O14497;O96019;P51532;P60709;Q12824;Q8TAQ2;Q92922;Q969G3;Q96GM5	8289;86;6597;60;6598;6601;6599;6605;6602	MI:0006-anti bait coimmunoprecipitation	GO:0006265;GO:0045893;GO:0003677;GO:0051276;GO:0005634	DNA topological change;positive regulation of DNA-templated transcription;DNA binding;chromosome organization;nucleus	10.01.09.05;11.02.03.04.01;16.03.01;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription activation;DNA binding;organization of chromosome structure;nucleus	9845365	Beta-actin and BAF53 directly interact with BRG1 in the BAF complex. The actin subunit is required for optimal ATPase activity of BRG1.	None	Since the authors did not specify SMARCD, we used isoform SMARCD1.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	AT-rich interactive domain-containing protein 1A;Actin-like protein 6A;Transcription activator BRG1;Actin, cytoplasmic 1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1;SWI/SNF complex subunit SMARCC2;SWI/SNF complex subunit SMARCC1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1	ARID1A;ACTL6A;SMARCA4;ACTB;SMARCB1;SMARCC2;SMARCC1;SMARCE1;SMARCD1	BAF250 BAF250A C1orf4 OSA1 SMARCF1;BAF53 BAF53A INO80K;BAF190A BRG1 SNF2B SNF2L4;None;BAF47, INI1, SNF5L1;BAF170;BAF155;BAF57;BAF60A
570	p300-CBP-p270-SWI/SNF complex	Human	None	None	O14497;P51532;Q09472;Q12824;Q8TAQ2;Q92793;Q92922	8289;6597;2033;6598;6601;1387;6599	MI:0006-anti bait coimmunoprecipitation	GO:0006265;GO:0045893;GO:0006473;GO:0003677;GO:0051276;GO:0005694	DNA topological change;positive regulation of DNA-templated transcription;protein acetylation;DNA binding;chromosome organization;chromosome	10.01.09.05;11.02.03.04.01;14.07.04;16.03.01;42.10.03;70.10.03	DNA conformation modification (e.g. chromatin);transcription activation;modification by acetylation, deacetylation;DNA binding;organization of chromosome structure;chromosome	9584200	None	None	Several other, not further characterized members of the complex have been isolated: p75,p71,p64,p59 and p50.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	AT-rich interactive domain-containing protein 1A;Transcription activator BRG1;Histone acetyltransferase p300;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1;SWI/SNF complex subunit SMARCC2;CREB-binding protein;SWI/SNF complex subunit SMARCC1	ARID1A;SMARCA4;EP300;SMARCB1;SMARCC2;CREBBP;SMARCC1	BAF250 BAF250A C1orf4 OSA1 SMARCF1;BAF190A BRG1 SNF2B SNF2L4;P300;BAF47, INI1, SNF5L1;BAF170;CBP;BAF155
571	p300-CBP-p270 complex	Human	None	None	O14497;Q09472;Q92793	8289;2033;1387	MI:0006-anti bait coimmunoprecipitation	GO:0045893;GO:0003677;GO:0005634	positive regulation of DNA-templated transcription;DNA binding;nucleus	11.02.03.04.01;16.03.01;70.10	transcription activation;DNA binding;nucleus	8995708	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	AT-rich interactive domain-containing protein 1A;Histone acetyltransferase p300;CREB-binding protein	ARID1A;EP300;CREBBP	BAF250 BAF250A C1orf4 OSA1 SMARCF1;P300;CBP
575	ABIN2-NFKB1-MAP3K8 complex	Human	None	HeLa S3 cells	P19838;P41279;Q8NFZ5	4790;1326;79155	MI:0096-pull down	GO:0050821;GO:0006457;GO:0005515;GO:0035556	protein stabilization;protein folding;protein binding;intracellular signal transduction	14.01;16.01;30.01	protein folding and stabilization;protein binding;cellular signalling	15169888	The optimal TPL-2 stability in vivo requires interaction with ABIN-2 as well as p105. Together, these data raise the possibility that ABIN-2 functions in the TLR4 signaling pathway which regulates TPL-2 activation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Nuclear factor NF-kappa-B p105 subunit;Mitogen-activated protein kinase kinase kinase 8;TNFAIP3-interacting protein 2	NFKB1;MAP3K8;TNIP2	None;COT ESTF;ABIN2 FLIP1
577	FHL2-p53-HIPK2 complex	Human	None	HEK293 cells	P04637;Q14192;Q9H2X6	7157;2274;28996	MI:0019-coimmunoprecipitation	GO:2001141;GO:0006355;GO:0005634	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;nucleus	11.02.03.04;70.10	transcriptional control;nucleus	16343438	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cellular tumor antigen p53;Four and a half LIM domains protein 2;Homeodomain-interacting protein kinase 2	TP53;FHL2;HIPK2	P53;DRAL SLIM3;None
585	Mi2/NuRD-BCL6-MTA3 complex	Human	None	None	O95983;P41182;Q13547;Q14839;Q9BTC8	53615;604;3065;1108;57504	MI:0006-anti bait coimmunoprecipitation	GO:0006265;GO:0045892;GO:0006476;GO:0051276;GO:0030183;GO:0005634	DNA topological change;negative regulation of DNA-templated transcription;protein deacetylation;chromosome organization;B cell differentiation;nucleus	10.01.09.05;11.02.03.04.03;14.07.04;42.10.03;43.03.07.02.01.01;70.10	DNA conformation modification (e.g. chromatin);transcription repression;modification by acetylation, deacetylation;organization of chromosome structure;B-cell;nucleus	15454082	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Methyl-CpG-binding domain protein 3;B-cell lymphoma 6 protein;Histone deacetylase 1;Chromodomain-helicase-DNA-binding protein 4;Metastasis-associated protein MTA3	MBD3;BCL6;HDAC1;CHD4;MTA3	None;BCL5 LAZ3 ZBTB27 ZNF51;RPD3L1;None;KIAA1266
587	NuRD.1 complex	Human	nucleosome remodeling and histone deacetylation complex	KB cell line	O95983;Q09028;Q13330;Q13547;Q14839;Q16576;Q92769	53615;5928;9112;3065;1108;5931;3066	MI:0004-affinity chromatography technology;MI:0091-chromatography technology	GO:0006265;GO:0045892;GO:0006476;GO:0009755;GO:0023052;GO:0051276;GO:0005634;GO:0016575	DNA topological change;negative regulation of DNA-templated transcription;protein deacetylation;hormone-mediated signaling pathway;signaling;chromosome organization;nucleus;histone deacetylation	10.01.09.05;11.02.03.04.03;14.07.04;30.01.09.08;30.01;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription repression;modification by acetylation, deacetylation;hormone mediated signal transduction;cellular signalling;organization of chromosome structure;nucleus	9885572	None	None	Several other subunits of the complex were found in the analysis, which have not been further characterized: N190, N170, N160, N140, N135, N130, N85, N75, N68, N66, N38.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Methyl-CpG-binding domain protein 3;Histone-binding protein RBBP4;Metastasis-associated protein MTA1;Histone deacetylase 1;Chromodomain-helicase-DNA-binding protein 4;Histone-binding protein RBBP7;Histone deacetylase 2	MBD3;RBBP4;MTA1;HDAC1;CHD4;RBBP7;HDAC2	None;RBAP48;None;RPD3L1;None;RBAP46;None
591	SAP complex (Sin3-associated protein complex)	Human	None	None	O75446;Q09028;Q13547;Q16576;Q4LE39;Q92769;Q96ST3;Q9H0E3	8819;5928;3065;5931;51742;3066;25942;79595	MI:0004-affinity chromatography technology	GO:0006265;GO:0045892;GO:0006476;GO:0051276;GO:0005634	DNA topological change;negative regulation of DNA-templated transcription;protein deacetylation;chromosome organization;nucleus	10.01.09.05;11.02.03.04.03;14.07.04;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription repression;modification by acetylation, deacetylation;organization of chromosome structure;nucleus	9885572	None	None	In PMID:12724404, SAP45 has been identified as an additional member of the complex.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone deacetylase complex subunit SAP30;Histone-binding protein RBBP4;Histone deacetylase 1;Histone-binding protein RBBP7;AT-rich interactive domain-containing protein 4B;Histone deacetylase 2;Paired amphipathic helix protein Sin3a;Histone deacetylase complex subunit SAP130	SAP30;RBBP4;HDAC1;RBBP7;ARID4B;HDAC2;SIN3A;SAP130	None;RBAP48;RPD3L1;RBAP46;BRCAA1 RBBP1L1 RBP1L1 SAP180;None;None;None
592	mSin3A corepressor complex	Human	mSin3A complex; SAP complex (Sin3-associated protein complex)	K562 erythroleukemia cells	O75446;Q09028;Q13547;Q16576;Q4LE39;Q92769;Q96ST3;Q9H0E3;Q9H7L9	8819;5928;3065;5931;51742;3066;25942;79595;64426	MI:0004-affinity chromatography technology;MI:0006-anti bait coimmunoprecipitation;MI:0091-chromatography technology	GO:0006265;GO:0045892;GO:0051276;GO:0005634;GO:0006476;GO:0016575	DNA topological change;negative regulation of DNA-templated transcription;chromosome organization;nucleus;protein deacetylation;histone deacetylation	10.01.09.05;11.02.03.04.03;42.10.03;70.10;14.07.04	DNA conformation modification (e.g. chromatin);transcription repression;organization of chromosome structure;nucleus;modification by acetylation, deacetylation	12724404	Three new mSin3A-associated proteins (SAP): SAP180, SAP130, and SAP45 have been identified during the purification of the complex in K562 erythroleukemia cells. Each new SAP is able to repress transcription when tethered to DNA.	None	SAP45 has been newly identified as a member of the SAP complex. Two other subunits of the complex were found in the analysis, which have not been further characterized: SAP38, SAP28.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone deacetylase complex subunit SAP30;Histone-binding protein RBBP4;Histone deacetylase 1;Histone-binding protein RBBP7;AT-rich interactive domain-containing protein 4B;Histone deacetylase 2;Paired amphipathic helix protein Sin3a;Histone deacetylase complex subunit SAP130;Sin3 histone deacetylase corepressor complex component SDS3	SAP30;RBBP4;HDAC1;RBBP7;ARID4B;HDAC2;SIN3A;SAP130;SUDS3	None;RBAP48;RPD3L1;RBAP46;BRCAA1 RBBP1L1 RBP1L1 SAP180;None;None;None;SAP45 SDS3
595	Kv4.2-DPP10 channel complex	Human	None	None	Q8N608;Q9NZV8	57628;3751	MI:0019-coimmunoprecipitation	GO:0006605;GO:0015031;GO:0006812;GO:0005216;GO:0001508;GO:0019227;GO:0019228;GO:0005886	protein targeting;protein transport;cation transport;ion channel activity;action potential;neuronal action potential propagation;neuronal action potential;plasma membrane	14.04;20.01.10;20.01.01.01;20.03.01.01;34.03.03;70.02	protein targeting, sorting and translocation;protein transport;cation transport (H+, Na+, K+, Ca2+ , NH4+, etc.);ion channels;regulation, generation and propagation of action potential;eukaryotic plasma membrane / membrane attached	15454437	This study shows that, similar to DPP6, DPP10 may play a critical part in the assembly of the Kv4 macromolecular complex in the brain and modulate its function.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Inactive dipeptidyl peptidase 10;Potassium voltage-gated channel subfamily D member 2	DPP10;KCND2	DPRP3 KIAA1492;KIAA1044
605	TIM23 subcomplex (TIMM17A, TIMM23, TIMM44), mitochondrial	Human	TIM (TIM17A, TIM23, TIM44) complex, mitochondrial	mitochondria from frozen HeLa cells; multiple human adult and fetal tissues	O14925;O43615;Q99595	100287932;10469;10440	MI:0019-coimmunoprecipitation;MI:0047-far western blotting;MI:0071-molecular sieving	GO:0005743;GO:0005744;GO:0071806;GO:0005739;GO:0006626;GO:0015031;GO:0006839	mitochondrial inner membrane;TIM23 mitochondrial import inner membrane translocase complex;protein transmembrane transport;mitochondrion;protein targeting to mitochondrion;protein transport;mitochondrial transport	70.16.05;70.16;20.01.10;20.09.04	mitochondrial inner membrane;mitochondrion;protein transport;mitochondrial transport	10339406	Translocation of nuclear-encoded mitochondrial preproteins is mediated by translocases in the outer (TOM) and inner (TIM)  membranes.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mitochondrial import inner membrane translocase subunit Tim23;Mitochondrial import inner membrane translocase subunit TIM44;Mitochondrial import inner membrane translocase subunit Tim17-A	TIMM23;TIMM44;TIMM17A	TIM23;MIMT44, TIM44;MIMT17 TIM17 TIM17A TIMM17
610	MSL complex	Human	None	K562 cells	Q7Z3B3;Q8N5Y2;Q9H7Z6;Q9HCI7	284058;10943;84148;55167	MI:0019-coimmunoprecipitation	GO:0006265;GO:0006473;GO:0006476;GO:0005634	DNA topological change;protein acetylation;protein deacetylation;nucleus	10.01.09.05;14.07.04;70.10	DNA conformation modification (e.g. chromatin);modification by acetylation, deacetylation;nucleus	16227571	The authors found that reduction in the levels of hMSLs and acetylation of H4 at lysine 16 are correlated with reduced transcription of some genes and with a G2/M cell cycle arrest.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	KAT8 regulatory NSL complex subunit 1;Male-specific lethal 3 homolog;Histone acetyltransferase KAT8;E3 ubiquitin-protein ligase MSL2	KANSL1;MSL3;KAT8;MSL2	CENP-36 KIAA1267 MSL1V1 NSL1;MSL3L1;MOF MYST1;KIAA1585 MSL2L1 RNF184
612	CTF18-CTF8-DCC1 complex	Human	None	HeLa cells	P0CG13;Q8WVB6;Q9BVC3	54921;63922;79075	MI:0019-coimmunoprecipitation	GO:0007049;GO:0007059;GO:0005634	cell cycle;chromosome segregation;nucleus	10.03;10.03.04.05;70.10	cell cycle;chromosome segregation/division;nucleus	12766176	This complex is required for sister chromatid cohesion and loads proliferating cell nuclear antigen onto DNA (PMID:12930902).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Chromosome transmission fidelity protein 8 homolog;Chromosome transmission fidelity protein 18 homolog;Sister chromatid cohesion protein DCC1	CHTF8;CHTF18;DSCC1	CTF8;C16orf41 CTF18;DCC1
613	CTF18-CTF8-DCC1-RFC3 complex	Human	None	HeLa cells	P0CG13;P40938;Q8WVB6;Q9BVC3	54921;5983;63922;79075	MI:0019-coimmunoprecipitation	GO:0005515;GO:0005634	protein binding;nucleus	16.01;70.10	protein binding;nucleus	12766176	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Chromosome transmission fidelity protein 8 homolog;Replication factor C subunit 3;Chromosome transmission fidelity protein 18 homolog;Sister chromatid cohesion protein DCC1	CHTF8;RFC3;CHTF18;DSCC1	CTF8;None;C16orf41 CTF18;DCC1
614	NRD complex (Nucleosome remodeling and deacetylation complex)	Human	None	None	O60341;Q09028;Q12873;Q13330;Q13547;Q14839;Q92769	23028;5928;1107;9112;3065;1108;3066	MI:0006-anti bait coimmunoprecipitation	GO:0006265;GO:2001141;GO:0006355;GO:0006476;GO:0051276;GO:0005634	DNA topological change;regulation of RNA biosynthetic process;regulation of DNA-templated transcription;protein deacetylation;chromosome organization;nucleus	10.01.09.05;11.02.03.04;14.07.04;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcriptional control;modification by acetylation, deacetylation;organization of chromosome structure;nucleus	9804427	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Lysine-specific histone demethylase 1A;Histone-binding protein RBBP4;Chromodomain-helicase-DNA-binding protein 3;Metastasis-associated protein MTA1;Histone deacetylase 1;Chromodomain-helicase-DNA-binding protein 4;Histone deacetylase 2	KDM1A;RBBP4;CHD3;MTA1;HDAC1;CHD4;HDAC2	AOF2 KDM1 KIAA0601 LSD1;RBAP48;None;None;RPD3L1;None;None
617	CASK-LIN7C-APBA1 complex	Human	None	brain	O14936;Q02410;Q9NUP9	8573;320;55327	MI:0019-coimmunoprecipitation	GO:0006886;GO:0006605;GO:0015031;GO:0006497	intracellular protein transport;protein targeting;protein transport;protein lipidation	14.04;20.01.10;14.07.01	protein targeting, sorting and translocation;protein transport;modification with fatty acids (e.g. myristylation, palmitylation, farnesylation)	9822620	This complex may play an important role in the trafficking and processing of APP in neurons.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Peripheral plasma membrane protein CASK;Amyloid-beta A4 precursor protein-binding family A member 1;Protein lin-7 homolog C	CASK;APBA1;LIN7C	LIN2;MINT1 X11;MALS3 VELI3
619	MRE11A-RAD50-NBN-TRF2 complex	Human	None	HeLa cells	O60934;P49959;Q15554;Q92878	4683;4361;7014;10111	MI:0019-coimmunoprecipitation;MI:0069-mass spectrometry studies of complexes	GO:0000075;GO:0003677;GO:0051276;GO:0005694	cell cycle checkpoint signaling;DNA binding;chromosome organization;chromosome	10.03.01.03;16.03.01;42.10.03;70.10.03	cell cycle checkpoints (checkpoints of morphogenesis, DNA-damage,-replication, mitotic phase and spindle);DNA binding;organization of chromosome structure;chromosome	10888888	Several experiments indicate that TRF2 is not involved in DSB repair. RAD50-MRE11-NBS1 complex functions at telomeres, possibly by modulating t-loop formation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Nibrin;Double-strand break repair protein MRE11;Telomeric repeat-binding factor 2;DNA repair protein RAD50	NBN;MRE11;TERF2;RAD50	NBS NBS1 P95;HNGS1 MRE11A;TRBF2, TRF2;None
620	CoREST-HDAC complex	Human	None	HeLa cells	O60341;O75362;Q13547;Q92769;Q96BD5;Q9P0W2;Q9UKL0	23028;7764;3065;3066;51317;10362;23186	MI:0006-anti bait coimmunoprecipitation	GO:0006265;GO:0045892;GO:0006476;GO:0051276;GO:0005634;GO:0019048;GO:0051607	DNA topological change;negative regulation of DNA-templated transcription;protein deacetylation;chromosome organization;nucleus;modulation by virus of host process;defense response to virus	10.01.09.05;11.02.03.04.03;14.07.04;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription repression;modification by acetylation, deacetylation;organization of chromosome structure;nucleus	11171972	Herpes simplex virus (HSV)-1 protein ICP0 binds to CoREST and disrupts the binding of HDAC1 to the CoREST-REST complex to block CoREST-mediated silencing of viral genes (PMID:15897453).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Lysine-specific histone demethylase 1A;Zinc finger protein 217;Histone deacetylase 1;Histone deacetylase 2;PHD finger protein 21A;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related;REST corepressor 1	KDM1A;ZNF217;HDAC1;HDAC2;PHF21A;HMG20B;RCOR1	AOF2 KDM1 KIAA0601 LSD1;ZABC1;RPD3L1;None;BHC80 KIAA1696;BRAF35 HMGX2 HMGXB2 SMARCE1R;KIAA0071 RCOR
622	Ubiquitin E3 ligase (VHL, TCEB1, TCEB2, CUL2)	Human	None	HeLa cells	P40337;Q13617;Q15369;Q15370	7428;8453;6921;6923	MI:0019-coimmunoprecipitation;MI:0051-fluorescence technology	GO:0016567;GO:0030163;GO:0005737;GO:0005634;GO:0006511	protein ubiquitination;protein catabolic process;cytoplasm;nucleus;ubiquitin-dependent protein catabolic process	14.07.05;14.13;70.03;70.10;14.13.01.01	modification by ubiquitination, deubiquitination;protein/peptide degradation;cytoplasm;nucleus;proteasomal degradation (ubiquitin/proteasomal pathway)	9122164	Ubiquitin E3 ligases covalently attach ubiquitin to a lysine residue on a target protein. Polyubiquitination marks proteins for degradation by the proteasome.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	von Hippel-Lindau disease tumor suppressor;Cullin-2;Elongin-C;Elongin-B	VHL;CUL2;ELOC;ELOB	None;None;TCEB1;TCEB2
623	Small TIM chaperone complex (TIMM9, TIMM10), mitochondrial	Human	TIM9.10 complex	in vitro	P62072;Q9Y5J7	26519;26520	MI:0004-affinity chromatography technology;MI:0040-electron microscopy	GO:0042719;GO:0005758;GO:0006839	mitochondrial intermembrane space protein transporter complex;mitochondrial intermembrane space;mitochondrial transport	70.16.03;20.09.04	mitochondrial intermembrane space;mitochondrial transport	16387659	Tim9 and Tim10 are translocase components of the intermembrane space and are associated with TIM22 at the mitochondrial inner membrane.	related to deafness-dystonia peptide 1 (DDP1)	human fetal kidney cDNA expressed in E.coli	Homo sapiens (Human);Homo sapiens (Human)	Mitochondrial import inner membrane translocase subunit Tim10;Mitochondrial import inner membrane translocase subunit Tim9	TIMM10;TIMM9	TIM10;TIM9 TIM9A TIMM9A
624	LSD1-CoREST complex	Human	None	in vitro	O60341;Q9UKL0	23028;23186	MI:0114-x-ray crystallography	GO:0006265;GO:0045892;GO:0016577;GO:0051276;GO:0005634	DNA topological change;negative regulation of DNA-templated transcription;histone demethylation;chromosome organization;nucleus	10.01.09.05;11.02.03.04.03;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription repression;organization of chromosome structure;nucleus	16885027	CoREST endows LSD1 with the ability to demethylate nucleosomal substrates and protects LSD1 from proteasomal degradation in vivo.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Lysine-specific histone demethylase 1A;REST corepressor 1	KDM1A;RCOR1	AOF2 KDM1 KIAA0601 LSD1;KIAA0071 RCOR
626	LSD1 complex	Human	None	None	O60341;O75362;P0DMV8;P0DMV9;Q13363;Q13547;Q92766;Q96BD5;Q96EK2;Q9NP66;Q9P0W2;Q9P2K3;Q9UBW7;Q9UKL0	23028;7764;3303;3304;1487;3065;6239;51317;112885;10363;10362;55758;7750;23186	MI:0004-affinity chromatography technology	GO:0006265;GO:0045892;GO:0051276;GO:0005634;GO:0016577	DNA topological change;negative regulation of DNA-templated transcription;chromosome organization;nucleus;histone demethylation	10.01.09.05;11.02.03.04.03;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription repression;organization of chromosome structure;nucleus	16140033	CoREST positively regulates LSD1 function, while BHC80 inhibits CoREST/LSD1-mediated demethylation in vitro. These findings suggest that LSD1-mediated histone demethylation is regulated dynamically in vivo.	None	Another subunit of the complex was found in the analysis, which has not been further characterized: Y182.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Lysine-specific histone demethylase 1A;Zinc finger protein 217;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1B;C-terminal-binding protein 1;Histone deacetylase 1;Ras-responsive element-binding protein 1;PHD finger protein 21A;PHD finger protein 21B;High mobility group protein 20A;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related;REST corepressor 3;Zinc finger MYM-type protein 2;REST corepressor 1	KDM1A;ZNF217;HSPA1A;HSPA1B;CTBP1;HDAC1;RREB1;PHF21A;PHF21B;HMG20A;HMG20B;RCOR3;ZMYM2;RCOR1	AOF2 KDM1 KIAA0601 LSD1;ZABC1;HSP72 HSPA1 HSX70;HSP72;CTBP;RPD3L1;FINB;BHC80 KIAA1696;KIAA1661;HMGX1 HMGXB1;BRAF35 HMGX2 HMGXB2 SMARCE1R;KIAA1343;FIM RAMP ZNF198;KIAA0071 RCOR
627	MRN-TRRAP complex (MRE11A-RAD50-NBN-TRRAP complex)	Human	None	HeLa cells	O60934;P49959;Q92878;Q9Y4A5	4683;4361;10111;8295	MI:0019-coimmunoprecipitation;MI:0069-mass spectrometry studies of complexes	GO:0006308;GO:0006281;GO:0000075;GO:0003677;GO:0006974;GO:0005634	DNA catabolic process;DNA repair;cell cycle checkpoint signaling;DNA binding;cellular response to DNA damage stimulus;nucleus	01.03.16.03;10.01.05.01;10.03.01.03;16.03.01;32.01.09;70.10	DNA degradation;DNA repair;cell cycle checkpoints (checkpoints of morphogenesis, DNA-damage,-replication, mitotic phase and spindle);DNA binding;DNA damage response;nucleus	16382133	TRRAP-depleted extracts show a reduced nonhomologous DNA end-joining activity in vitro. TRRAP may function as a molecular link between DSB signaling, repair, and chromatin remodeling.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Nibrin;Double-strand break repair protein MRE11;DNA repair protein RAD50;Transformation/transcription domain-associated protein	NBN;MRE11;RAD50;TRRAP	NBS NBS1 P95;HNGS1 MRE11A;None;PAF400
629	BLM-TRF2 complex	Human	None	in vitro	P54132;P62380	641;9519	MI:0019-coimmunoprecipitation;MI:0055-fluorescent resonance energy transfer	GO:0051276;GO:0090398	chromosome organization;cellular senescence	42.10.03	organization of chromosome structure	12444098	None	BLM is involved in Bloom syndrome (BS).	The results identify BLM as the first protein found to affect telomeric DNA synthesis specifically in human ALT immortalized cell lines.	Homo sapiens (Human);Homo sapiens (Human)	RecQ-like DNA helicase BLM;TATA box-binding protein-like 1	BLM;TBPL1	RECQ2 RECQL3;TLF TLP TLP21 TRF2 TRP
631	AuroraA-chTOG-Tacc1  complex	Human	AURKA-CKAP5-TACC1 complex	breast cancer cells	O14965;O75410;Q14008	6790;6867;9793	MI:0018-two hybrid;MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0051225;GO:0007098;GO:0006417;GO:0000775	spindle assembly;centrosome cycle;regulation of translation;chromosome, centromeric region	10.03.05.01;12.07;70.10.04	spindle pole body/centrosome and microtubule cycle;translational control;centromere / kinetochore	14603251	This complex could be involved in the regulation of mRNA translation, cell division in conjunction and microtubule organization.	This complex may be affected during mammary gland oncogenesis.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Aurora kinase A;Transforming acidic coiled-coil-containing protein 1;Cytoskeleton-associated protein 5	AURKA;TACC1;CKAP5	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6;KIAA1103;KIAA0097
632	Anti-HDAC2 complex	Human	None	None	O60341;O94776;P78347;Q09028;Q12873;Q13330;Q13547;Q14202;Q14687;Q14839;Q16576;Q92769;Q96BD5;Q96ST3;Q9P0W2;Q9UBW7;Q9UKL0	23028;9219;2969;5928;1107;9112;3065;9203;23199;1108;5931;3066;51317;25942;10362;7750;23186	MI:0006-anti bait coimmunoprecipitation;MI:0091-chromatography technology	GO:0006265;GO:0045892;GO:0006476;GO:0051276;GO:0005634	DNA topological change;negative regulation of DNA-templated transcription;protein deacetylation;chromosome organization;nucleus	10.01.09.05;11.02.03.04.03;14.07.04;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription repression;modification by acetylation, deacetylation;organization of chromosome structure;nucleus	12493763	None	XFIM (ZMYM3) is involved in X-linked mental retardation.	Since the authors did not specify SIN3, we used isoform SIN3A.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Lysine-specific histone demethylase 1A;Metastasis-associated protein MTA2;General transcription factor II-I;Histone-binding protein RBBP4;Chromodomain-helicase-DNA-binding protein 3;Metastasis-associated protein MTA1;Histone deacetylase 1;Zinc finger MYM-type protein 3;Genetic suppressor element 1;Chromodomain-helicase-DNA-binding protein 4;Histone-binding protein RBBP7;Histone deacetylase 2;PHD finger protein 21A;Paired amphipathic helix protein Sin3a;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related;Zinc finger MYM-type protein 2;REST corepressor 1	KDM1A;MTA2;GTF2I;RBBP4;CHD3;MTA1;HDAC1;ZMYM3;GSE1;CHD4;RBBP7;HDAC2;PHF21A;SIN3A;HMG20B;ZMYM2;RCOR1	AOF2 KDM1 KIAA0601 LSD1;MTA1L1 PID;BAP135 WBSCR6;RBAP48;None;None;RPD3L1;DXS6673E KIAA0385 ZNF261;KIAA0182;None;RBAP46;None;BHC80 KIAA1696;None;BRAF35 HMGX2 HMGXB2 SMARCE1R;FIM RAMP ZNF198;KIAA0071 RCOR
633	anti-BHC110 complex	Human	None	None	O60341;O75362;P78347;Q13547;Q14202;Q14687;Q92769;Q96BD5;Q9P0W2;Q9UBW7;Q9UKL0	23028;7764;2969;3065;9203;23199;3066;51317;10362;7750;23186	MI:0006-anti bait coimmunoprecipitation;MI:0091-chromatography technology	GO:0006265;GO:0045892;GO:0006476;GO:0051276;GO:0005634	DNA topological change;negative regulation of DNA-templated transcription;protein deacetylation;chromosome organization;nucleus	10.01.09.05;11.02.03.04.03;14.07.04;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription repression;modification by acetylation, deacetylation;organization of chromosome structure;nucleus	12493763	None	XFIM (ZMYM3) is involved in X-linked mental retardation.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Lysine-specific histone demethylase 1A;Zinc finger protein 217;General transcription factor II-I;Histone deacetylase 1;Zinc finger MYM-type protein 3;Genetic suppressor element 1;Histone deacetylase 2;PHD finger protein 21A;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related;Zinc finger MYM-type protein 2;REST corepressor 1	KDM1A;ZNF217;GTF2I;HDAC1;ZMYM3;GSE1;HDAC2;PHF21A;HMG20B;ZMYM2;RCOR1	AOF2 KDM1 KIAA0601 LSD1;ZABC1;BAP135 WBSCR6;RPD3L1;DXS6673E KIAA0385 ZNF261;KIAA0182;None;BHC80 KIAA1696;BRAF35 HMGX2 HMGXB2 SMARCE1R;FIM RAMP ZNF198;KIAA0071 RCOR
634	XFIM complex	Human	None	None	O60341;P78347;Q13547;Q14202;Q92769	23028;2969;3065;9203;3066	MI:0007-anti tag coimmunoprecipitation;MI:0071-molecular sieving	GO:0006265;GO:0045892;GO:0032774;GO:0006476;GO:0051276;GO:0005634	DNA topological change;negative regulation of DNA-templated transcription;RNA biosynthetic process;protein deacetylation;chromosome organization;nucleus	10.01.09.05;11.02.03.04.03;11.02;14.07.04;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription repression;RNA synthesis;modification by acetylation, deacetylation;organization of chromosome structure;nucleus	12493763	None	XFIM (ZMYM3) is involved in X-linked mental retardation.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Lysine-specific histone demethylase 1A;General transcription factor II-I;Histone deacetylase 1;Zinc finger MYM-type protein 3;Histone deacetylase 2	KDM1A;GTF2I;HDAC1;ZMYM3;HDAC2	AOF2 KDM1 KIAA0601 LSD1;BAP135 WBSCR6;RPD3L1;DXS6673E KIAA0385 ZNF261;None
635	AGPS-GNPAT complex	Human	None	in vitro	O00116;O15228	8540;8443	MI:0030-cross-linking study	GO:0006720;GO:0006633;GO:0008299;GO:0009062;GO:0016042;GO:0008300;GO:0006629;GO:0006631;GO:0008610;GO:0005777	isoprenoid metabolic process;fatty acid biosynthetic process;isoprenoid biosynthetic process;fatty acid catabolic process;lipid catabolic process;isoprenoid catabolic process;lipid metabolic process;fatty acid metabolic process;lipid biosynthetic process;peroxisome	01.06;01.06.05;01.06.06;70.19	lipid, fatty acid and isoprenoid metabolism;fatty acid metabolism;isoprenoid metabolism;peroxisome	10215861	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Alkyldihydroxyacetonephosphate synthase, peroxisomal;Dihydroxyacetone phosphate acyltransferase	AGPS;GNPAT	None;DAPAT DHAPAT
636	BHC complex	Human	BRAF-histone deacetylase complex, BRAF-HDAC complex	None	O60341;Q13547;Q92769;Q96BD5;Q9P0W2;Q9UKL0	23028;3065;3066;51317;10362;23186	MI:0004-affinity chromatography technology;MI:0006-anti bait coimmunoprecipitation;MI:0007-anti tag coimmunoprecipitation;MI:0091-chromatography technology	GO:0006265;GO:0045892;GO:0006476;GO:0051276;GO:0030182;GO:0005634	DNA topological change;negative regulation of DNA-templated transcription;protein deacetylation;chromosome organization;neuron differentiation;nucleus	10.01.09.05;11.02.03.04.03;14.07.04;42.10.03;43.03.13;70.10	DNA conformation modification (e.g. chromatin);transcription repression;modification by acetylation, deacetylation;organization of chromosome structure;neuron;nucleus	12032298	The BHC complex mediates repression of neuron-specific genes.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Lysine-specific histone demethylase 1A;Histone deacetylase 1;Histone deacetylase 2;PHD finger protein 21A;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related;REST corepressor 1	KDM1A;HDAC1;HDAC2;PHF21A;HMG20B;RCOR1	AOF2 KDM1 KIAA0601 LSD1;RPD3L1;None;BHC80 KIAA1696;BRAF35 HMGX2 HMGXB2 SMARCE1R;KIAA0071 RCOR
641	RANBPM-SMP1 complex	Human	None	HeLa cells	O95807;Q96S59	23585;10048	MI:0018-two hybrid;MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0007276;GO:0005737	gamete generation;cytoplasm	41.05.25;70.03	gametogenesis;cytoplasm	15014887	This complex may be involved in the process of male germ cell differentiation.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Transmembrane protein 50A;Ran-binding protein 9	TMEM50A;RANBP9	SMP1;RANBPM
642	CtBP complex	Human	None	None	O00257;O60315;O60341;O75362;P37275;P56545;Q13363;Q13547;Q92618;Q92766;Q92769;Q96JN0;Q96KQ7;Q9H9B1;Q9P2K3;Q9UKL0;Q9Y232	8535;9839;23028;7764;6935;1488;1487;3065;9658;6239;3066;84458;10919;79813;55758;23186;9425	MI:0007-anti tag coimmunoprecipitation	GO:0006265;GO:0045892;GO:0003677;GO:0051276;GO:0005634;GO:0016577	DNA topological change;negative regulation of DNA-templated transcription;DNA binding;chromosome organization;nucleus;histone demethylation	10.01.09.05;11.02.03.04.03;16.03.01;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription repression;DNA binding;organization of chromosome structure;nucleus	12700765	None	CtBP is implicated in tumorigenesis.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 SUMO-protein ligase CBX4;Zinc finger E-box-binding homeobox 2;Lysine-specific histone demethylase 1A;Zinc finger protein 217;Zinc finger E-box-binding homeobox 1;C-terminal-binding protein 2;C-terminal-binding protein 1;Histone deacetylase 1;Zinc finger protein 516;Ras-responsive element-binding protein 1;Histone deacetylase 2;Ligand-dependent corepressor;Histone-lysine N-methyltransferase EHMT2;Histone-lysine N-methyltransferase EHMT1;REST corepressor 3;REST corepressor 1;Chromodomain Y-like protein	CBX4;ZEB2;KDM1A;ZNF217;ZEB1;CTBP2;CTBP1;HDAC1;ZNF516;RREB1;HDAC2;LCOR;EHMT2;EHMT1;RCOR3;RCOR1;CDYL	None;KIAA0569 SIP1 ZFHX1B ZFX1B;AOF2 KDM1 KIAA0601 LSD1;ZABC1;AREB6 TCF8;None;CTBP;RPD3L1;KIAA0222;FINB;None;C10orf12 KIAA1795 MLR2;BAT8 C6orf30 G9A KMT1C NG36;EUHMTASE1 GLP KIAA1876 KMT1D;KIAA1343;KIAA0071 RCOR;CDYL1
643	CtBP core complex	Human	None	None	O60341;P37275;P56545;Q13363;Q13547;Q92769;Q96KQ7;Q9H9B1;Q9UKL0	23028;6935;1488;1487;3065;3066;10919;79813;23186	MI:0029-cosedimentation through density gradient;MI:0071-molecular sieving	GO:0006265;GO:0045892;GO:0003677;GO:0051276;GO:0005634;GO:0016577	DNA topological change;negative regulation of DNA-templated transcription;DNA binding;chromosome organization;nucleus;histone demethylation	10.01.09.05;11.02.03.04.03;16.03.01;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription repression;DNA binding;organization of chromosome structure;nucleus	12700765	None	CtBP is implicated in tumorigenesis.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Lysine-specific histone demethylase 1A;Zinc finger E-box-binding homeobox 1;C-terminal-binding protein 2;C-terminal-binding protein 1;Histone deacetylase 1;Histone deacetylase 2;Histone-lysine N-methyltransferase EHMT2;Histone-lysine N-methyltransferase EHMT1;REST corepressor 1	KDM1A;ZEB1;CTBP2;CTBP1;HDAC1;HDAC2;EHMT2;EHMT1;RCOR1	AOF2 KDM1 KIAA0601 LSD1;AREB6 TCF8;None;CTBP;RPD3L1;None;BAT8 C6orf30 G9A KMT1C NG36;EUHMTASE1 GLP KIAA1876 KMT1D;KIAA0071 RCOR
644	ASPP1-SAM68 complex	Human	None	in vitro	Q07666;Q96KQ4	10657;23368	MI:0018-two hybrid	GO:0008380;GO:0005634	RNA splicing;nucleus	11.04.03.01;70.10	splicing;nucleus	16474851	The authors suggest that the interaction of ASPP1 with nuclear SAM68 is spatially restricted to human spermatogenesis.	None	None	Homo sapiens (Human);Homo sapiens (Human)	KH domain-containing, RNA-binding, signal transduction-associated protein 1;Apoptosis-stimulating of p53 protein 1	KHDRBS1;PPP1R13B	SAM68;ASPP1 KIAA0771
646	HDAC1-associated protein complex	Human	None	None	O60341;O94776;O95983;Q09028;Q12873;Q13547;Q16576;Q9UBB5;Q9UKL0	23028;9219;53615;5928;1107;3065;5931;8932;23186	MI:0006-anti bait coimmunoprecipitation;MI:0007-anti tag coimmunoprecipitation	GO:0006265;GO:0045892;GO:0003677;GO:0051276;GO:0005634;GO:0016575	DNA topological change;negative regulation of DNA-templated transcription;DNA binding;chromosome organization;nucleus;histone deacetylation	10.01.09.05;11.02.03.04.03;16.03.01;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription repression;DNA binding;organization of chromosome structure;nucleus	11102443	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Lysine-specific histone demethylase 1A;Metastasis-associated protein MTA2;Methyl-CpG-binding domain protein 3;Histone-binding protein RBBP4;Chromodomain-helicase-DNA-binding protein 3;Histone deacetylase 1;Histone-binding protein RBBP7;Methyl-CpG-binding domain protein 2;REST corepressor 1	KDM1A;MTA2;MBD3;RBBP4;CHD3;HDAC1;RBBP7;MBD2;RCOR1	AOF2 KDM1 KIAA0601 LSD1;MTA1L1 PID;None;RBAP48;None;RPD3L1;RBAP46;None;KIAA0071 RCOR
648	HDAC1-associated core complex cI	Human	None	None	O60341;Q13547;Q9UKL0	23028;3065;23186	MI:0006-anti bait coimmunoprecipitation;MI:0007-anti tag coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0006265;GO:0045892;GO:0006476;GO:0003677;GO:0051276;GO:0005634;GO:0016575	DNA topological change;negative regulation of DNA-templated transcription;protein deacetylation;DNA binding;chromosome organization;nucleus;histone deacetylation	10.01.09.05;11.02.03.04.03;14.07.04;16.03.01;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription repression;modification by acetylation, deacetylation;DNA binding;organization of chromosome structure;nucleus	11102443	None	None	Another subunit of the complex was found in the analysis, which has not been further characterized: p37.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Lysine-specific histone demethylase 1A;Histone deacetylase 1;REST corepressor 1	KDM1A;HDAC1;RCOR1	AOF2 KDM1 KIAA0601 LSD1;RPD3L1;KIAA0071 RCOR
649	HDAC1-associated core complex cII	Human	None	None	O94776;O95983;Q09028;Q12873;Q13547;Q16576;Q86YP4;Q9UBB5;Q9UKL0	9219;53615;5928;1107;3065;5931;54815;8932;23186	MI:0006-anti bait coimmunoprecipitation;MI:0007-anti tag coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0006265;GO:0045892;GO:0003677;GO:0051276;GO:0005634;GO:0016575	DNA topological change;negative regulation of DNA-templated transcription;DNA binding;chromosome organization;nucleus;histone deacetylation	10.01.09.05;11.02.03.04.03;16.03.01;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription repression;DNA binding;organization of chromosome structure;nucleus	11102443	None	None	Since the authors did not specify GATAD2, we used isoform GATAD2A.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Metastasis-associated protein MTA2;Methyl-CpG-binding domain protein 3;Histone-binding protein RBBP4;Chromodomain-helicase-DNA-binding protein 3;Histone deacetylase 1;Histone-binding protein RBBP7;Transcriptional repressor p66-alpha;Methyl-CpG-binding domain protein 2;REST corepressor 1	MTA2;MBD3;RBBP4;CHD3;HDAC1;RBBP7;GATAD2A;MBD2;RCOR1	MTA1L1 PID;None;RBAP48;None;RPD3L1;RBAP46;None;None;KIAA0071 RCOR
650	HDAC2-asscociated core complex	Human	None	None	O94776;O95983;Q09028;Q12873;Q16576;Q86YP4;Q92769	9219;53615;5928;1107;5931;54815;3066	MI:0007-anti tag coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0006265;GO:0045892;GO:0003677;GO:0051276;GO:0005634;GO:0016575	DNA topological change;negative regulation of DNA-templated transcription;DNA binding;chromosome organization;nucleus;histone deacetylation	10.01.09.05;11.02.03.04.03;16.03.01;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription repression;DNA binding;organization of chromosome structure;nucleus	11102443	None	None	Since the authors did not specify GATAD2, we used isoform GATAD2A.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Metastasis-associated protein MTA2;Methyl-CpG-binding domain protein 3;Histone-binding protein RBBP4;Chromodomain-helicase-DNA-binding protein 3;Histone-binding protein RBBP7;Transcriptional repressor p66-alpha;Histone deacetylase 2	MTA2;MBD3;RBBP4;CHD3;RBBP7;GATAD2A;HDAC2	MTA1L1 PID;None;RBAP48;None;RBAP46;None;None
652	AP3-BLOC1 complex	Human	None	HeLa cells	O00203;O14617;O95295;P78537;Q6QNY0;Q6QNY1;Q8TDH9;Q92572;Q96EV8;Q9NUP1;Q9UL45;Q9Y2T2	8546;8943;23557;2647;388552;282991;63915;1176;84062;55330;26258;26985	MI:0019-coimmunoprecipitation	GO:0035654;GO:0060627;GO:0032438	clathrin-coated vesicle cargo loading, AP-3-mediated;regulation of vesicle-mediated transport;melanosome organization	None	None	16837549	BLOC-1 interacts physically and functionally with AP-3 to facilitate the trafficking of a known AP-3 cargo.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	AP-3 complex subunit beta-1;AP-3 complex subunit delta-1;SNARE-associated protein Snapin;Biogenesis of lysosome-related organelles complex 1 subunit 1;Biogenesis of lysosome-related organelles complex 1 subunit 3;Biogenesis of lysosome-related organelles complex 1 subunit 2;Biogenesis of lysosome-related organelles complex 1 subunit 5;AP-3 complex subunit sigma-1;Dysbindin;Biogenesis of lysosome-related organelles complex 1 subunit 4;Biogenesis of lysosome-related organelles complex 1 subunit 6;AP-3 complex subunit mu-1	AP3B1;AP3D1;SNAPIN;BLOC1S1;BLOC1S3;BLOC1S2;BLOC1S5;AP3S1;DTNBP1;BLOC1S4;BLOC1S6;AP3M1	ADTB3A;None;BLOC1S7 SNAP25BP SNAPAP;BLOS1 GCN5L1 RT14;BLOS3;BLOS2 CEAP;MUTED;CLAPS3;BLOC1S8;CNO;PA, PLDN;None
654	BLOC1-BLOC2 complex	Human	None	None	O95295;P78537;Q6QNY0;Q6QNY1;Q86YV9;Q8TDH9;Q969F9;Q96EV8;Q9NUP1;Q9UL45;Q9UPZ3	23557;2647;388552;282991;79803;63915;84343;84062;55330;26258;11234	MI:0019-coimmunoprecipitation	GO:0006886;GO:0006605;GO:0015031;GO:0005768	intracellular protein transport;protein targeting;protein transport;endosome	14.04;20.01.10;70.22	protein targeting, sorting and translocation;protein transport;endosome	16837549	BLOC-1 interacts with BLOC-2 to facilitate Tyrp1 trafficking by a mechanism apparently independent of AP-3 function.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	SNARE-associated protein Snapin;Biogenesis of lysosome-related organelles complex 1 subunit 1;Biogenesis of lysosome-related organelles complex 1 subunit 3;Biogenesis of lysosome-related organelles complex 1 subunit 2;BLOC-2 complex member HPS6;Biogenesis of lysosome-related organelles complex 1 subunit 5;BLOC-2 complex member HPS3;Dysbindin;Biogenesis of lysosome-related organelles complex 1 subunit 4;Biogenesis of lysosome-related organelles complex 1 subunit 6;BLOC-2 complex member HPS5	SNAPIN;BLOC1S1;BLOC1S3;BLOC1S2;HPS6;BLOC1S5;HPS3;DTNBP1;BLOC1S4;BLOC1S6;HPS5	BLOC1S7 SNAP25BP SNAPAP;BLOS1 GCN5L1 RT14;BLOS3;BLOS2 CEAP;None;MUTED;None;BLOC1S8;CNO;PA, PLDN;AIBP63 KIAA1017
655	HSF1-HSF2 complex	Human	None	None	Q00613;Q03933	3297;3298	MI:0019-coimmunoprecipitation	GO:0005515	protein binding	16.01	protein binding	16336210	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Heat shock factor protein 1;Heat shock factor protein 2	HSF1;HSF2	HSTF1;HSTF2
656	VPS35-VPS29-VPS26A complex	Human	None	None	O75436;Q96QK1;Q9UBQ0	9559;55737;51699	MI:0019-coimmunoprecipitation	GO:0006886;GO:0006605;GO:0015031	intracellular protein transport;protein targeting;protein transport	14.04;20.01.10	protein targeting, sorting and translocation;protein transport	11102511	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Vacuolar protein sorting-associated protein 26A;Vacuolar protein sorting-associated protein 35;Vacuolar protein sorting-associated protein 29	VPS26A;VPS35;VPS29	VPS26;MEM3;None
657	Retromer complex (SNX1, SNX2, VPS35, VPS29, VPS26A)	Human	None	HeLa cells; crystallized human proteins	O60749;O75436;Q13596;Q96QK1;Q9UBQ0	6643;9559;6642;55737;51699	MI:0113-western blot;MI:0019-coimmunoprecipitation;MI:0051-fluorescence technology	GO:0006886;GO:0006605;GO:0015031;GO:0016192;GO:0036465;GO:0000301	intracellular protein transport;protein targeting;protein transport;vesicle-mediated transport;synaptic vesicle recycling;retrograde transport, vesicle recycling within Golgi	14.04;20.01.10;20.09.07;20.09.07.29;20.09.07.07	protein targeting, sorting and translocation;protein transport;vesicular transport (Golgi network, etc.);vesicle recycling;retrograde transport	16732284	The mammalian retromer complex consists of SNX1, SNX2, Vps26, Vps29 and Vps35, and retrieves lysosomal enzyme receptors from endosomes to the trans-Golgi network.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Sorting nexin-2;Vacuolar protein sorting-associated protein 26A;Sorting nexin-1;Vacuolar protein sorting-associated protein 35;Vacuolar protein sorting-associated protein 29	SNX2;VPS26A;SNX1;VPS35;VPS29	None;VPS26;None;MEM3;None
662	HOXA9-MEIS1-PBX2 complex	Human	None	human U-937 and KG1 myeloid leukemia cells	O00470;P31269;P40425	4211;3205;5089	MI:0007-anti tag coimmunoprecipitation;MI:0019-coimmunoprecipitation;MI:0413-electrophoretic mobility shift assay;MI:0416-fluorescence microscopy	GO:0003677;GO:0030218;GO:0005634	DNA binding;erythrocyte differentiation;nucleus	16.03.01;43.03.07;70.10	DNA binding;blood cell;nucleus	10082572	MEIS1 is capable of forming a triple complex with HOXA9 and each of the three known PBX proteins in the absence of DNA (PMID:10082572).	Aberrant activation of the HOX, MEIS, and PBX homeodomain protein families is associated with leukemias, and retrovirally driven coexpression of HOXA9 and MEIS1 is sufficient to induce myeloid leukemia in mice (cited in PMID:10082572).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Homeobox protein Meis1;Homeobox protein Hox-A9;Pre-B-cell leukemia transcription factor 2	MEIS1;HOXA9;PBX2	None;HOX1G;G17
668	BKCA-beta2AR-AKAP79 signaling complex	Human	None	None	P07550;P24588;Q12791	154;9495;3778	MI:0019-coimmunoprecipitation	GO:0008324;GO:0006812;GO:0005216;GO:0007186;GO:0050896;GO:0006939	cation transmembrane transporter activity;cation transport;ion channel activity;G protein-coupled receptor signaling pathway;response to stimulus;smooth muscle contraction	20.01.01.01;20.03.01.01;30.05.02.24;36.25;36.25.09.01	cation transport (H+, Na+, K+, Ca2+ , NH4+, etc.);ion channels;G-protein coupled receptor signalling pathway;animal specific systemic sensing and response;smooth muscle contraction	15141163	BKCa is preferentially regulated by beta2AR within the channel macromolecular complex. Only expression of all three components of the complex reconstituted full-beta2 agonist modulation of the channel.  The ability of beta2AR to form a complex with BKCa, and concomitantly bind phosphorylation-modulatory components (AKAP79/150) enables specific and local regulation of BKCa channels and defines a signal transduction pathway governing cellular excitability in diverse tissues.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Beta-2 adrenergic receptor;A-kinase anchor protein 5;Calcium-activated potassium channel subunit alpha-1	ADRB2;AKAP5;KCNMA1	ADRB2R B2AR;AKAP79;KCNMA SLO
672	BKCA-beta2AR complex	Human	None	lung	P07550;Q12791	154;3778	MI:0019-coimmunoprecipitation	GO:0008324;GO:0006812;GO:0005216;GO:0007186;GO:0050896	cation transmembrane transporter activity;cation transport;ion channel activity;G protein-coupled receptor signaling pathway;response to stimulus	20.01.01.01;20.03.01.01;30.05.02.24;36.25	cation transport (H+, Na+, K+, Ca2+ , NH4+, etc.);ion channels;G-protein coupled receptor signalling pathway;animal specific systemic sensing and response	15141163	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Beta-2 adrenergic receptor;Calcium-activated potassium channel subunit alpha-1	ADRB2;KCNMA1	ADRB2R B2AR;KCNMA SLO
678	GINS complex	Human	None	None	Q14691;Q9BRT9;Q9BRX5;Q9Y248	9837;84296;64785;51659	MI:0019-coimmunoprecipitation	GO:0006267;GO:0003688;GO:0005634	pre-replicative complex assembly involved in nuclear cell cycle DNA replication;DNA replication origin binding;nucleus	10.01.03.03;70.10	ori recognition and priming complex formation;nucleus	17170760	This complex stimulates DNA polymerase alpha-primase.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA replication complex GINS protein PSF1;DNA replication complex GINS protein SLD5;DNA replication complex GINS protein PSF3;DNA replication complex GINS protein PSF2	GINS1;GINS4;GINS3;GINS2	KIAA0186 PSF1;SLD5;PSF3;PSF2
680	RANBMP-CD39 complex	Human	None	lymphocyte	P43487;P49961	5902;953	MI:0019-coimmunoprecipitation	GO:0030234;GO:0050790;GO:0005886	enzyme regulator activity;regulation of catalytic activity;plasma membrane	18.02.01;70.02	enzymatic activity regulation / enzyme regulator;eukaryotic plasma membrane / membrane attached	16478441	NTPDase activity of recombinant CD39, but not of N-terminus-deleted-CD39 mutant, is substantially diminished by RanBPM co-expression in COS-7 cells.CD39 associations with RanBPM have the potential to regulate NTPDase catalytic activity.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Ran-specific GTPase-activating protein;Ectonucleoside triphosphate diphosphohydrolase 1	RANBP1;ENTPD1	None;CD39
682	C-CFTR-NHERF-ezrin complex	Human	None	epithelium	O14745;P13569;P15311	9368;1080;7430	MI:0019-coimmunoprecipitation;MI:0067-light scattering;MI:0071-molecular sieving;MI:0107-surface plasmon resonance	GO:0006821;GO:0005216;GO:0005886;GO:0005856	chloride transport;ion channel activity;plasma membrane;cytoskeleton	20.01.01.07.09;20.03.01.01;70.02;70.04	chloride transport;ion channels;eukaryotic plasma membrane / membrane attached;cytoskeleton	16129695	There are two types of 1:1:1 ternary complexes formed between C-CFTR and NHERF\u00b7ezFERM. Ezrin is a regulator that can positively control the cooperative binding of NHERF with the cytoplasmic domains of CFTR, thus modulating the stoichiometry of C-CFTR to NHERF interaction. The regulation of NHERF by ezrin may be employed as a general mechanism to assemble channels and receptors in the membrane cytoskeleton.	CFTR is involved in cystic fibrosis (PMID:10811849).	Gel filtration experiments show that the fraction eluted at 11.3 ml is a ternary complex with C-CFTR bound to the first PDZ domain of the binary NHERF\u00b7ezFERM complex.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Na(+)/H(+) exchange regulatory cofactor NHE-RF1;Cystic fibrosis transmembrane conductance regulator;Ezrin	SLC9A3R1;CFTR;EZR	NHERF NHERF1;ABCC7;VIL2
684	PAX9-MSX1 complex	Human	None	None	P28360;P55771	4487;5083	MI:0018-two hybrid;MI:0019-coimmunoprecipitation	GO:2001141;GO:0006355;GO:0042476	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;odontogenesis	11.02.03.04;41.05.12	transcriptional control;odontogenesis	15721141	None	PAX9 is involved  in tooth agenesis. The results indicate a functional relationship between Pax9 and Msx1 during tooth development.	None	Homo sapiens (Human);Homo sapiens (Human)	Homeobox protein MSX-1;Paired box protein Pax-9	MSX1;PAX9	HOX7;
685	MeCP1 complex	Human	Mi2/NuRD-MBD2 complex	HEK293T cells	O94776;O95983;Q09028;Q13547;Q14839;Q16576;Q8WXI9;Q92769;Q9UBB5	9219;53615;5928;3065;1108;5931;57459;3066;8932	MI:0006-anti bait coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0051276;GO:0003677;GO:0016575;GO:0006265;GO:0045892;GO:0005634	chromosome organization;DNA binding;histone deacetylation;DNA topological change;negative regulation of DNA-templated transcription;nucleus	42.10.03;16.03.01;10.01.09.05;11.02.03.04.03;70.10	organization of chromosome structure;DNA binding;DNA conformation modification (e.g. chromatin);transcription repression;nucleus	11756549	MeCP1 protein complex represses transcription through preferential binding, remodeling, and deacetylation of methylated nucleosomes.	None	The uncharacterized subunits of the MeCP1 complex (CORUM-ID 659, published in PMID: 11297506) are two different forms of the same zinc finger-containing protein GATAD2B.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Metastasis-associated protein MTA2;Methyl-CpG-binding domain protein 3;Histone-binding protein RBBP4;Histone deacetylase 1;Chromodomain-helicase-DNA-binding protein 4;Histone-binding protein RBBP7;Transcriptional repressor p66-beta;Histone deacetylase 2;Methyl-CpG-binding domain protein 2	MTA2;MBD3;RBBP4;HDAC1;CHD4;RBBP7;GATAD2B;HDAC2;MBD2	MTA1L1 PID;None;RBAP48;RPD3L1;None;RBAP46;KIAA1150;None;None
687	CFTR-NHERF-beta(2)AR signaling complex	Human	None	epithelium	O14745;P07550;P13569	9368;154;1080	MI:0006-anti bait coimmunoprecipitation;MI:0096-pull down	GO:0006821;GO:0005216;GO:0023052;GO:0005886	chloride transport;ion channel activity;signaling;plasma membrane	20.01.01.07.09;20.03.01.01;30.01;70.02	chloride transport;ion channels;cellular signalling;eukaryotic plasma membrane / membrane attached	12502786	The results indicate that PDZ-based interactions with ezrin/radixin/moesin-binding phosphoprotein 50 (EBP50) govern both physical and functional regulation of CFTR by beta (2) AR. Assembly of the complex is regulated by PKA-dependent phosphorylation.	CFTR is involved in cystic fibrosis (PMID:10811849).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Na(+)/H(+) exchange regulatory cofactor NHE-RF1;Beta-2 adrenergic receptor;Cystic fibrosis transmembrane conductance regulator	SLC9A3R1;ADRB2;CFTR	NHERF NHERF1;ADRB2R B2AR;ABCC7
691	SIN3-SAP25 complex	Human	None	HEK293T cells	O00422;O75446;Q09028;Q13547;Q16576;Q4LE39;Q8TEE9;Q92769;Q96ST3;Q9H0E3;Q9H7L9	10284;8819;5928;3065;5931;51742;100316904;3066;25942;79595;64426	MI:0007-anti tag coimmunoprecipitation	GO:0006265;GO:0045892;GO:0006476;GO:0051276;GO:0005634	DNA topological change;negative regulation of DNA-templated transcription;protein deacetylation;chromosome organization;nucleus	10.01.09.05;11.02.03.04.03;14.07.04;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription repression;modification by acetylation, deacetylation;organization of chromosome structure;nucleus	16449650	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone deacetylase complex subunit SAP18;Histone deacetylase complex subunit SAP30;Histone-binding protein RBBP4;Histone deacetylase 1;Histone-binding protein RBBP7;AT-rich interactive domain-containing protein 4B;Histone deacetylase complex subunit SAP25;Histone deacetylase 2;Paired amphipathic helix protein Sin3a;Histone deacetylase complex subunit SAP130;Sin3 histone deacetylase corepressor complex component SDS3	SAP18;SAP30;RBBP4;HDAC1;RBBP7;ARID4B;SAP25;HDAC2;SIN3A;SAP130;SUDS3	None;None;RBAP48;RPD3L1;RBAP46;BRCAA1 RBBP1L1 RBP1L1 SAP180;None;None;None;None;SAP45 SDS3
695	SIN3-HDAC-SAP30-ARID4 complex	Human	mSin3A corepressor complex	K562 cells	O75446;Q09028;Q13547;Q16576;Q4LE39;Q92769;Q96ST3	8819;5928;3065;5931;51742;3066;25942	MI:0006-anti bait coimmunoprecipitation	GO:0006265;GO:0045892;GO:0006476;GO:0005515;GO:0051276;GO:0005634	DNA topological change;negative regulation of DNA-templated transcription;protein deacetylation;protein binding;chromosome organization;nucleus	10.01.09.05;11.02.03.04.03;14.07.04;16.01;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription repression;modification by acetylation, deacetylation;protein binding;organization of chromosome structure;nucleus	12724404	None	None	Another subunit of the complex was found in the analysis, which has not been further characterized: SAP250.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone deacetylase complex subunit SAP30;Histone-binding protein RBBP4;Histone deacetylase 1;Histone-binding protein RBBP7;AT-rich interactive domain-containing protein 4B;Histone deacetylase 2;Paired amphipathic helix protein Sin3a	SAP30;RBBP4;HDAC1;RBBP7;ARID4B;HDAC2;SIN3A	None;RBAP48;RPD3L1;RBAP46;BRCAA1 RBBP1L1 RBP1L1 SAP180;None;None
696	BRMS1-mSin3A corepressor complex	Human	BRMS1-SIN3-HDAC complex	C8161.9 cells, MDA-MB-231 human breast carcinoma cells	O75182;O75446;Q09028;Q13547;Q16576;Q92769;Q96ST3;Q9HCU9	23309;8819;5928;3065;5931;3066;25942;25855	MI:0007-anti tag coimmunoprecipitation	GO:0006265;GO:0045892;GO:0006476;GO:0051276;GO:0005634;GO:0016575	DNA topological change;negative regulation of DNA-templated transcription;protein deacetylation;chromosome organization;nucleus;histone deacetylation	10.01.09.05;11.02.03.04.03;14.07.04;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription repression;modification by acetylation, deacetylation;organization of chromosome structure;nucleus	14581478	BRMS1 may participate in transcriptional regulation via interaction with the Sin3-HDAC complex and suggest a novel mechanism by which BRMS1 might suppress cancer metastasis.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Paired amphipathic helix protein Sin3b;Histone deacetylase complex subunit SAP30;Histone-binding protein RBBP4;Histone deacetylase 1;Histone-binding protein RBBP7;Histone deacetylase 2;Paired amphipathic helix protein Sin3a;Breast cancer metastasis-suppressor 1	SIN3B;SAP30;RBBP4;HDAC1;RBBP7;HDAC2;SIN3A;BRMS1	KIAA0700;None;RBAP48;RPD3L1;RBAP46;None;None;None
697	BRMS1-RBP1 complex	Human	None	None	Q4LE39;Q9HCU9	51742;25855	MI:0007-anti tag coimmunoprecipitation	GO:0045892;GO:0005634	negative regulation of DNA-templated transcription;nucleus	11.02.03.04.03;70.10	transcription repression;nucleus	14581478	BRMS1 may participate in transcriptional regulation via interaction with the mSin3.HDAC complex and suggest a novel mechanism by which BRMS1 might suppress cancer metastasis.	None	None	Homo sapiens (Human);Homo sapiens (Human)	AT-rich interactive domain-containing protein 4B;Breast cancer metastasis-suppressor 1	ARID4B;BRMS1	BRCAA1 RBBP1L1 RBP1L1 SAP180;None
702	NAA10-NAA15 complex	Human	ARD1-NATH complex	None	P41227;Q9BXJ9	8260;80155	MI:0019-coimmunoprecipitation;MI:0051-fluorescence technology	GO:0006417;GO:0005515;GO:0005634	regulation of translation;protein binding;nucleus	12.07;16.01;70.10	translational control;protein binding;nucleus	15496142	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	N-alpha-acetyltransferase 10;N-alpha-acetyltransferase 15, NatA auxiliary subunit	NAA10;NAA15	ARD1 ARD1A TE2;GA19 NARG1 NATH TBDN100
705	RINT1-USE1-ZW10 subcomplex	Human	RINT1-ZW10-p31 subcomplex	HeLa cells; 293T cells	O43264;Q6NUQ1;Q9NZ43	9183;60561;55850	MI:0019-coimmunoprecipitation;MI:0047-far western blotting	GO:0000776;GO:0031577;GO:0005783	kinetochore;spindle checkpoint signaling;endoplasmic reticulum	70.07	endoplasmic reticulum	15029241	p31, RINT-1 and ZW10 form a subcomplex in the syntaxin 18 complex.	None	ZW10 is known to be a component of the kinetochores and plays an important role in termination of the spindle checkpoint. ZW10 is involved in membrane trafficking between the endoplasmic reticulum and Golgi. Sequence comparison suggests that p31 is a mammalian ortholog of Use1p/Slt1p.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Centromere/kinetochore protein zw10 homolog;RAD50-interacting protein 1;Vesicle transport protein USE1	ZW10;RINT1;USE1	None;None;USE1L
706	SNARE complex (HGS, SNAP25, STX13)	Human	HGS-containing complex	HeLa cells	O14964;P60880;Q86Y82	9146;6616;23673	MI:0047-far western blotting	GO:0006906;GO:0048489;GO:0016079;GO:0005768;GO:0031201;GO:0061025	vesicle fusion;synaptic vesicle transport;synaptic vesicle exocytosis;endosome;SNARE complex;membrane fusion	20.09.07.27;20.09.16.09.05;70.22	vesicle fusion;synaptic vesicle exocytosis;endosome	14769786	SNARE (N-ethylmaleimide-sensitive factor attachment protein receptor) complexes are responsible for membrane fusion in the secretory pathway.	None	STX12 and STX13 are identical (see GeneID:23673): "STX12 syntaxin 12 (Homo sapiens) also known as STX13; STX14; MGC51957".	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Hepatocyte growth factor-regulated tyrosine kinase substrate;Synaptosomal-associated protein 25;Syntaxin-12	HGS;SNAP25;STX12	HRS;SNAP;None
707	SNARE complex (SNAP25, STX13, VAMP2)	Human	None	HeLa cells	P60880;P63027;Q86Y82	6616;6844;23673	MI:0047-far western blotting	GO:0061025;GO:0031201;GO:0034058	membrane fusion;SNARE complex;endosomal vesicle fusion	None	None	14769786	SNARE (N-ethylmaleimide-sensitive factor attachment protein receptor) complexes are responsible for membrane fusion in the secretory pathway.	None	STX12 and STX13 are identical (see GeneID:23673): "STX12 syntaxin 12 (Homo sapiens) Also known as STX13; STX14; MGC51957".	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Synaptosomal-associated protein 25;Vesicle-associated membrane protein 2;Syntaxin-12	SNAP25;VAMP2;STX12	SNAP;SYB2;None
710	Brg1-associated complex I	Human	None	None	O14497;O14744;O96019;P51532;Q12824;Q8TAQ2;Q92922;Q969G3;Q96GM5	8289;10419;86;6597;6598;6601;6599;6605;6602	MI:0007-anti tag coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0006265;GO:2001141;GO:0006355;GO:0003677;GO:0051276;GO:0005634	DNA topological change;regulation of RNA biosynthetic process;regulation of DNA-templated transcription;DNA binding;chromosome organization;nucleus	10.01.09.05;11.02.03.04;16.03.01;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcriptional control;DNA binding;organization of chromosome structure;nucleus	11238380	None	None	In a following paper (PMID:14559996) p66 has been identified as PRMT5. Since the authors did not specify SMARCD, we used isoform SMARCD1.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	AT-rich interactive domain-containing protein 1A;Protein arginine N-methyltransferase 5;Actin-like protein 6A;Transcription activator BRG1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1;SWI/SNF complex subunit SMARCC2;SWI/SNF complex subunit SMARCC1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1	ARID1A;PRMT5;ACTL6A;SMARCA4;SMARCB1;SMARCC2;SMARCC1;SMARCE1;SMARCD1	BAF250 BAF250A C1orf4 OSA1 SMARCF1;HRMT1L5 IBP72 JBP1 SKB1;BAF53 BAF53A INO80K;BAF190A BRG1 SNF2B SNF2L4;BAF47, INI1, SNF5L1;BAF170;BAF155;BAF57;BAF60A
711	Brm-associated complex	Human	BRM containing SWI/SNF remodeling complex	None	O14497;O14744;O96019;P51531;Q12824;Q8TAQ2;Q92922;Q969G3;Q96GM5	8289;10419;86;6595;6598;6601;6599;6605;6602	MI:0007-anti tag coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0006265;GO:2001141;GO:0006355;GO:0006479;GO:0003677;GO:0051276;GO:0005634	DNA topological change;regulation of RNA biosynthetic process;regulation of DNA-templated transcription;protein methylation;DNA binding;chromosome organization;nucleus	10.01.09.05;11.02.03.04;14.07.09;16.03.01;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcriptional control;posttranslational modification of amino acids (e.g. hydroxylation, methylation);DNA binding;organization of chromosome structure;nucleus	11238380	None	None	In a following paper (PMID:14559996) p66 has been identified as PRMT5. Since the authors did not specify SMARCD, we used isoform SMARCD1.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	AT-rich interactive domain-containing protein 1A;Protein arginine N-methyltransferase 5;Actin-like protein 6A;Probable global transcription activator SNF2L2;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1;SWI/SNF complex subunit SMARCC2;SWI/SNF complex subunit SMARCC1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1	ARID1A;PRMT5;ACTL6A;SMARCA2;SMARCB1;SMARCC2;SMARCC1;SMARCE1;SMARCD1	BAF250 BAF250A C1orf4 OSA1 SMARCF1;HRMT1L5 IBP72 JBP1 SKB1;BAF53 BAF53A INO80K;BAF190B BRM SNF2A SNF2L2;BAF47, INI1, SNF5L1;BAF170;BAF155;BAF57;BAF60A
713	BRG1-SIN3A complex	Human	None	None	O14497;O14744;O96019;P51532;Q09028;Q12824;Q6STE5;Q8TAQ2;Q92769;Q92922;Q92925;Q969G3;Q96GM5;Q96ST3	8289;10419;86;6597;5928;6598;6604;6601;3066;6599;6603;6605;6602;25942	MI:0007-anti tag coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0006265;GO:0045892;GO:0003677;GO:0051276;GO:0005634	DNA topological change;negative regulation of DNA-templated transcription;DNA binding;chromosome organization;nucleus	10.01.09.05;11.02.03.04.03;16.03.01;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription repression;DNA binding;organization of chromosome structure;nucleus	11238380	Components of the Sin3 complex cofractionate with BRG1-associated complex I, but not with BRG1-associated complex II.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	AT-rich interactive domain-containing protein 1A;Protein arginine N-methyltransferase 5;Actin-like protein 6A;Transcription activator BRG1;Histone-binding protein RBBP4;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3;SWI/SNF complex subunit SMARCC2;Histone deacetylase 2;SWI/SNF complex subunit SMARCC1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1;Paired amphipathic helix protein Sin3a	ARID1A;PRMT5;ACTL6A;SMARCA4;RBBP4;SMARCB1;SMARCD3;SMARCC2;HDAC2;SMARCC1;SMARCD2;SMARCE1;SMARCD1;SIN3A	BAF250 BAF250A C1orf4 OSA1 SMARCF1;HRMT1L5 IBP72 JBP1 SKB1;BAF53 BAF53A INO80K;BAF190A BRG1 SNF2B SNF2L4;RBAP48;BAF47, INI1, SNF5L1;BAF60C;BAF170;None;BAF155;BAF60B;BAF57;BAF60A;None
714	BRM-SIN3A complex	Human	None	None	O14497;O14744;O96019;P51531;Q09028;Q12824;Q13547;Q6STE5;Q8TAQ2;Q92769;Q92922;Q92925;Q969G3;Q96GM5;Q96ST3	8289;10419;86;6595;5928;6598;3065;6604;6601;3066;6599;6603;6605;6602;25942	MI:0007-anti tag coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0006265;GO:0045892;GO:0003677;GO:0051276;GO:0005634	DNA topological change;negative regulation of DNA-templated transcription;DNA binding;chromosome organization;nucleus	10.01.09.05;11.02.03.04.03;16.03.01;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription repression;DNA binding;organization of chromosome structure;nucleus	11238380	Components of the Sin3 complex cofractionate with BRM-associated complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	AT-rich interactive domain-containing protein 1A;Protein arginine N-methyltransferase 5;Actin-like protein 6A;Probable global transcription activator SNF2L2;Histone-binding protein RBBP4;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1;Histone deacetylase 1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3;SWI/SNF complex subunit SMARCC2;Histone deacetylase 2;SWI/SNF complex subunit SMARCC1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1;Paired amphipathic helix protein Sin3a	ARID1A;PRMT5;ACTL6A;SMARCA2;RBBP4;SMARCB1;HDAC1;SMARCD3;SMARCC2;HDAC2;SMARCC1;SMARCD2;SMARCE1;SMARCD1;SIN3A	BAF250 BAF250A C1orf4 OSA1 SMARCF1;HRMT1L5 IBP72 JBP1 SKB1;BAF53 BAF53A INO80K;BAF190B BRM SNF2A SNF2L2;RBAP48;BAF47, INI1, SNF5L1;RPD3L1;BAF60C;BAF170;None;BAF155;BAF60B;BAF57;BAF60A;None
720	PU.1-SIN3A-HDAC complex	Human	None	None	P17947;Q13547;Q96ST3	6688;3065;25942	MI:0007-anti tag coimmunoprecipitation	GO:0006265;GO:0045892;GO:0006476;GO:0003677;GO:0051276;GO:0005634	DNA topological change;negative regulation of DNA-templated transcription;protein deacetylation;DNA binding;chromosome organization;nucleus	10.01.09.05;11.02.03.04.03;14.07.04;16.03.01;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription repression;modification by acetylation, deacetylation;DNA binding;organization of chromosome structure;nucleus	11593411	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transcription factor PU.1;Histone deacetylase 1;Paired amphipathic helix protein Sin3a	SPI1;HDAC1;SIN3A	None;RPD3L1;None
721	PU.1-TBP complex	Human	None	None	P17947;P20226	6688;6908	MI:0007-anti tag coimmunoprecipitation	GO:0045892;GO:0003677;GO:0005634	negative regulation of DNA-templated transcription;DNA binding;nucleus	11.02.03.04.03;16.03.01;70.10	transcription repression;DNA binding;nucleus	14647463	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Transcription factor PU.1;TATA-box-binding protein	SPI1;TBP	None;GTF2D1 TF2D TFIID
723	MORF4L1-MRFAP1-RB1 complex	Human	MRG15-PAM14-RB complex; MAF1 complex;  MRG15-associated factors 1	EJ cells; CMV-MJ-Hel 1 cells	P06400;Q9UBU8;Q9Y605	5925;10933;93621	MI:0006-anti bait coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0045893;GO:0005634;GO:0090398	positive regulation of DNA-templated transcription;nucleus;cellular senescence	11.02.03.04.01;70.10	transcription activation;nucleus	12397079	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Retinoblastoma-associated protein;Mortality factor 4-like protein 1;MORF4 family-associated protein 1	RB1;MORF4L1;MRFAP1	None;MRG15;PAM14, PGR1
724	MAF2 complex	Human	MRG15-associated factors 2	EJ cells; CMV-MJ-Hel 1 cells	Q9H7Z6;Q9UBU8	84148;10933	MI:0006-anti bait coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0045893;GO:0006473;GO:0005634;GO:0090398	positive regulation of DNA-templated transcription;protein acetylation;nucleus;cellular senescence	11.02.03.04.01;14.07.04;70.10	transcription activation;modification by acetylation, deacetylation;nucleus	12397079	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Histone acetyltransferase KAT8;Mortality factor 4-like protein 1	KAT8;MORF4L1	MOF MYST1;MRG15
725	P2X7 receptor signalling complex	Human	None	None	O43707;O95425;P05107;P08238;P0DMV8;P11142;P23467;P42356;P60709;Q13368;Q16787;Q99572	81;6840;3689;3326;3303;3312;5787;5297;60;4356;3909;5027	MI:0019-coimmunoprecipitation	GO:0006811;GO:0005216;GO:0007166;GO:0007010;GO:0005886	ion transport;ion channel activity;cell surface receptor signaling pathway;cytoskeleton organization;plasma membrane	20.01.01;20.03.01.01;30.05;42.04;70.02	ion transport;ion channels;transmembrane signal transduction;cytoskeleton/structural proteins;eukaryotic plasma membrane / membrane attached	11707406	None	None	Since the authors did not specify HSP70, we used isoform HSPA1A.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Alpha-actinin-4;Supervillin;Integrin beta-2;Heat shock protein HSP 90-beta;Heat shock 70 kDa protein 1A;Heat shock cognate 71 kDa protein;Receptor-type tyrosine-protein phosphatase beta;Phosphatidylinositol 4-kinase alpha;Actin, cytoplasmic 1;MAGUK p55 subfamily member 3;Laminin subunit alpha-3;P2X purinoceptor 7	ACTN4;SVIL;ITGB2;HSP90AB1;HSPA1A;HSPA8;PTPRB;PI4KA;ACTB;MPP3;LAMA3;P2RX7	None;None;CD18 MFI7;HSP90B HSPC2 HSPCB;HSP72 HSPA1 HSX70;HSC70 HSP73 HSPA10;PTPB;PIK4 PIK4CA;None;DLG3;LAMNA;None
726	DDB2 complex	Human	Ubiquitin E3 ligase	None	P61201;P62877;Q13098;Q13619;Q16531;Q7L5N1;Q92466;Q92905;Q99627;Q9BT78;Q9UBW8;Q9UNS2	9318;9978;2873;8451;1642;10980;1643;10987;10920;51138;50813;8533	MI:0007-anti tag coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0006281;GO:0016567;GO:0003677;GO:0006974;GO:0005634;GO:0006511	DNA repair;protein ubiquitination;DNA binding;cellular response to DNA damage stimulus;nucleus;ubiquitin-dependent protein catabolic process	10.01.05.01;14.07.05;16.03.01;32.01.09;70.10;14.13.01.01	DNA repair;modification by ubiquitination, deubiquitination;DNA binding;DNA damage response;nucleus;proteasomal degradation (ubiquitin/proteasomal pathway)	12732143	Ubiquitin E3 ligases covalently attach ubiquitin to a lysine residue on a target protein. Polyubiquitination marks proteins for degradation by the proteasome. Results suggest that the distinct UV response of the DDB2 and CSA complexes is involved in diverse mechanisms of nucleotide excision repair (NER). The DDB2 complex binds to DNA after UV irradiation.	None	Since the authors did not specify COPS7, we used isoform COPS7A.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	COP9 signalosome complex subunit 2;E3 ubiquitin-protein ligase RBX1;COP9 signalosome complex subunit 1;Cullin-4A;DNA damage-binding protein 1;COP9 signalosome complex subunit 6;DNA damage-binding protein 2;COP9 signalosome complex subunit 5;COP9 signalosome complex subunit 8;COP9 signalosome complex subunit 4;COP9 signalosome complex subunit 7a;COP9 signalosome complex subunit 3	COPS2;RBX1;GPS1;CUL4A;DDB1;COPS6;DDB2;COPS5;COPS8;COPS4;COPS7A;COPS3	CSN2, TRIP15;RNF75 ROC1;COPS1, CSN1;None;XAP1;CSN6 HVIP;None;CSN5, JAB1;CSN8;CSN4;CSN7A DERP10;CSN3
727	CSA complex	Human	Ubiquitin E3 ligase	None	P61201;P62877;Q13098;Q13216;Q13619;Q16531;Q7L5N1;Q92905;Q99627;Q9BT78;Q9UBW8;Q9UNS2	9318;9978;2873;1161;8451;1642;10980;10987;10920;51138;50813;8533	MI:0007-anti tag coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0006281;GO:0016567;GO:0005515;GO:0006974;GO:0005634;GO:0006511	DNA repair;protein ubiquitination;protein binding;cellular response to DNA damage stimulus;nucleus;ubiquitin-dependent protein catabolic process	10.01.05.01;14.07.05;16.01;32.01.09;70.10;14.13.01.01	DNA repair;modification by ubiquitination, deubiquitination;protein binding;DNA damage response;nucleus;proteasomal degradation (ubiquitin/proteasomal pathway)	12732143	Ubiquitin E3 ligases covalently attach ubiquitin to a lysine residue on a target protein. Polyubiquitination marks proteins for degradation by the proteasome. Results suggest that the distinct UV response of the DDB2 and CSA complexes is involved in diverse mechanisms of nucleotide excision repair (NER). The CSA complex does not bind to DNA, regardless of UV damage.	None	Since the authors did not specify COPS7, we used isoform COPS7A.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	COP9 signalosome complex subunit 2;E3 ubiquitin-protein ligase RBX1;COP9 signalosome complex subunit 1;DNA excision repair protein ERCC-8;Cullin-4A;DNA damage-binding protein 1;COP9 signalosome complex subunit 6;COP9 signalosome complex subunit 5;COP9 signalosome complex subunit 8;COP9 signalosome complex subunit 4;COP9 signalosome complex subunit 7a;COP9 signalosome complex subunit 3	COPS2;RBX1;GPS1;ERCC8;CUL4A;DDB1;COPS6;COPS5;COPS8;COPS4;COPS7A;COPS3	CSN2, TRIP15;RNF75 ROC1;COPS1, CSN1;CKN1 CSA;None;XAP1;CSN6 HVIP;CSN5, JAB1;CSN8;CSN4;CSN7A DERP10;CSN3
728	CSA-POLIIa complex	Human	Ubiquitin E3 ligase	None	P24928;P61201;P62877;Q13098;Q13216;Q13619;Q16531;Q7L5N1;Q92905;Q99627;Q9BT78;Q9UBW8;Q9UNS2	5430;9318;9978;2873;1161;8451;1642;10980;10987;10920;51138;50813;8533	MI:0007-anti tag coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0006281;GO:0009299;GO:0016567;GO:0006974;GO:0005634;GO:0006511	DNA repair;mRNA transcription;protein ubiquitination;cellular response to DNA damage stimulus;nucleus;ubiquitin-dependent protein catabolic process	10.01.05.01;11.02.03;14.07.05;32.01.09;70.10;14.13.01.01	DNA repair;mRNA synthesis;modification by ubiquitination, deubiquitination;DNA damage response;nucleus;proteasomal degradation (ubiquitin/proteasomal pathway)	12732143	Ubiquitin E3 ligases covalently attach ubiquitin to a lysine residue on a target protein. Polyubiquitination marks proteins for degradation by the proteasome. This complex has been purified from UV-irradiated cells. Results suggest that the distinct UV response of the DDB2 and CSA complexes is involved in diverse mechanisms of nucleotide excision repair (NER).	None	Since the authors did not specify COPS7, we used isoform COPS7A.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA-directed RNA polymerase II subunit RPB1;COP9 signalosome complex subunit 2;E3 ubiquitin-protein ligase RBX1;COP9 signalosome complex subunit 1;DNA excision repair protein ERCC-8;Cullin-4A;DNA damage-binding protein 1;COP9 signalosome complex subunit 6;COP9 signalosome complex subunit 5;COP9 signalosome complex subunit 8;COP9 signalosome complex subunit 4;COP9 signalosome complex subunit 7a;COP9 signalosome complex subunit 3	POLR2A;COPS2;RBX1;GPS1;ERCC8;CUL4A;DDB1;COPS6;COPS5;COPS8;COPS4;COPS7A;COPS3	POLR2;CSN2, TRIP15;RNF75 ROC1;COPS1, CSN1;CKN1 CSA;None;XAP1;CSN6 HVIP;CSN5, JAB1;CSN8;CSN4;CSN7A DERP10;CSN3
729	Ubiquitin E3 ligase (FBXO31, SKP1A, CUL1, RBX1)	Human	None	None	P62877;P63208;Q13616;Q5XUX0	9978;6500;8454;79791	MI:0007-anti tag coimmunoprecipitation	GO:0000278;GO:0016567;GO:0030163;GO:0006511;GO:0090398	mitotic cell cycle;protein ubiquitination;protein catabolic process;ubiquitin-dependent protein catabolic process;cellular senescence	10.03.01.01;14.07.05;14.13;14.13.01.01	mitotic cell cycle;modification by ubiquitination, deubiquitination;protein/peptide degradation;proteasomal degradation (ubiquitin/proteasomal pathway)	16357137	Ubiquitin E3 ligases covalently attach ubiquitin to a lysine residue on a target protein. Polyubiquitination marks proteins for degradation by the proteasome. FBXO31 is the chromosome 16q24.3 senescence gene, a candidate breast tumor suppressor, and a component of an SCF complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase RBX1;S-phase kinase-associated protein 1;Cullin-1;F-box only protein 31	RBX1;SKP1;CUL1;FBXO31	RNF75 ROC1;EMC19 OCP2 SKP1A TCEB1L;None;FBX14 FBX31
730	SNARE complex (SNAP23, STX4, VAMP1)	Human	None	human neutrophil-differentiating HL-60 cells; human peripheral blood neutrophils	O00161;P23763;Q12846	8773;6843;6810	MI:0019-coimmunoprecipitation;MI:0040-electron microscopy;MI:0047-far western blotting;MI:0416-fluorescence microscopy	GO:0048489;GO:0016079;GO:0031201;GO:0099503;GO:0043312;GO:0070820;GO:0061025	synaptic vesicle transport;synaptic vesicle exocytosis;SNARE complex;secretory vesicle;neutrophil degranulation;tertiary granule;membrane fusion	20.09.16.09.05	synaptic vesicle exocytosis	16920918	SNARE (N-ethylmaleimide-sensitive factor attachment protein receptor) complexes are responsible for membrane fusion in the secretory pathway.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Synaptosomal-associated protein 23;Vesicle-associated membrane protein 1;Syntaxin-4	SNAP23;VAMP1;STX4	None;SYB1;STX4A
731	SNARE complex (SNAP23, STX4, VAMP2)	Human	None	human neutrophil-differentiating HL-60 cells; human peripheral blood neutrophils	O00161;P63027;Q12846	8773;6844;6810	MI:0019-coimmunoprecipitation;MI:0040-electron microscopy;MI:0047-far western blotting	GO:0006887;GO:0070820;GO:0016079;GO:0031201;GO:0043312;GO:0099503;GO:0061025	exocytosis;tertiary granule;synaptic vesicle exocytosis;SNARE complex;neutrophil degranulation;secretory vesicle;membrane fusion	20.09.16.09.03;20.09.16.09.05	exocytosis;synaptic vesicle exocytosis	16920918	SNARE (N-ethylmaleimide-sensitive factor attachment protein receptor) complexes are responsible for membrane fusion in the secretory pathway.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Synaptosomal-associated protein 23;Vesicle-associated membrane protein 2;Syntaxin-4	SNAP23;VAMP2;STX4	None;SYB2;STX4A
733	SNARE complex (STX4, VAMP1, VAMP7)	Human	None	human neutrophil-differentiating HL-60 cells; human peripheral blood neutrophils	P23763;P51809;Q12846	6843;6845;6810	MI:0019-coimmunoprecipitation;MI:0040-electron microscopy;MI:0047-far western blotting	GO:0006906;GO:0006887;GO:0042582;GO:0061025;GO:0031201	vesicle fusion;exocytosis;azurophil granule;membrane fusion;SNARE complex	20.09.07.27;20.09.16.09.03	vesicle fusion;exocytosis	16920918	SNARE (N-ethylmaleimide-sensitive factor attachment protein receptor) complexes are responsible for membrane fusion in the secretory pathway.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Vesicle-associated membrane protein 1;Vesicle-associated membrane protein 7;Syntaxin-4	VAMP1;VAMP7;STX4	SYB1;SYBL1;STX4A
738	SIN3-ING1b complex I	Human	None	HeLa cells	O00422;O75446;Q09028;Q13547;Q16576;Q4LE39;Q92769;Q96ST3;Q9UK53	10284;8819;5928;3065;5931;51742;3066;25942;3621	MI:0006-anti bait coimmunoprecipitation;MI:0091-chromatography technology	GO:0006265;GO:0045892;GO:0051276;GO:0005634;GO:0016575;GO:0006338	DNA topological change;negative regulation of DNA-templated transcription;chromosome organization;nucleus;histone deacetylation;chromatin remodeling	10.01.09.05;11.02.03.04.03;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription repression;organization of chromosome structure;nucleus	11784859	SAP30 is a specific component of Sin3 complexes since it is absent in other HDAC1/2-containing complexes such as NuRD.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone deacetylase complex subunit SAP18;Histone deacetylase complex subunit SAP30;Histone-binding protein RBBP4;Histone deacetylase 1;Histone-binding protein RBBP7;AT-rich interactive domain-containing protein 4B;Histone deacetylase 2;Paired amphipathic helix protein Sin3a;Inhibitor of growth protein 1	SAP18;SAP30;RBBP4;HDAC1;RBBP7;ARID4B;HDAC2;SIN3A;ING1	None;None;RBAP48;RPD3L1;RBAP46;BRCAA1 RBBP1L1 RBP1L1 SAP180;None;None;None
739	SIN3-ING1b complex II	Human	None	HeLa cells	O00422;O14497;O75446;O96019;P51532;Q09028;Q12824;Q13547;Q16576;Q4LE39;Q8TAQ2;Q92769;Q92922;Q96GM5;Q96ST3;Q9UK53	10284;8289;8819;86;6597;5928;6598;3065;5931;51742;6601;3066;6599;6602;25942;3621	MI:0006-anti bait coimmunoprecipitation;MI:0091-chromatography technology	GO:0006265;GO:0045892;GO:0051090;GO:0051276;GO:0005634;GO:0006338;GO:0016575	DNA topological change;negative regulation of DNA-templated transcription;regulation of DNA-binding transcription factor activity;chromosome organization;nucleus;chromatin remodeling;histone deacetylation	10.01.09.05;11.02.03.04.03;18.02.09;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription repression;regulator of transcription factor;organization of chromosome structure;nucleus	11784859	SAP30 is a specific component of Sin3 complexes since it is absent in other HDAC1/2-containing complexes such as NuRD.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone deacetylase complex subunit SAP18;AT-rich interactive domain-containing protein 1A;Histone deacetylase complex subunit SAP30;Actin-like protein 6A;Transcription activator BRG1;Histone-binding protein RBBP4;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1;Histone deacetylase 1;Histone-binding protein RBBP7;AT-rich interactive domain-containing protein 4B;SWI/SNF complex subunit SMARCC2;Histone deacetylase 2;SWI/SNF complex subunit SMARCC1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1;Paired amphipathic helix protein Sin3a;Inhibitor of growth protein 1	SAP18;ARID1A;SAP30;ACTL6A;SMARCA4;RBBP4;SMARCB1;HDAC1;RBBP7;ARID4B;SMARCC2;HDAC2;SMARCC1;SMARCD1;SIN3A;ING1	None;BAF250 BAF250A C1orf4 OSA1 SMARCF1;None;BAF53 BAF53A INO80K;BAF190A BRG1 SNF2B SNF2L4;RBAP48;BAF47, INI1, SNF5L1;RPD3L1;RBAP46;BRCAA1 RBBP1L1 RBP1L1 SAP180;BAF170;None;BAF155;BAF60A;None;None
740	Exon junction complex (EIF4A3, MLN51, MAGOH, Y14)	Human	None	None	O15234;P38919;P61326;Q9Y5S9	22794;9775;4116;9939	MI:0004-affinity chromatography technology;MI:0040-electron microscopy;MI:0071-molecular sieving;MI:0114-x-ray crystallography	GO:0043488;GO:0006417;GO:0003723;GO:0050658;GO:0051033;GO:0051169;GO:0005737;GO:0005634	regulation of mRNA stability;regulation of translation;RNA binding;RNA transport;RNA transmembrane transporter activity;nuclear transport;cytoplasm;nucleus	11.04.03.11;12.07;16.03.03;20.01.21;20.09.01;70.03;70.10	control of mRNA stability;translational control;RNA binding;RNA transport;nuclear transport;cytoplasm;nucleus	16797590	This protein complex remains stably bound to the mRNA through different cellular environments. Magoh and Y14 form a tight heterodimer. The authors propose a that eIF4AIII interacts with Y14:Magoh to enforce a compact arrangement of eIF4AIII's two domains and allow MLN51 to interact with both eIF4AIII and the RNA.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein CASC3;Eukaryotic initiation factor 4A-III;Protein mago nashi homolog;RNA-binding protein 8A	CASC3;EIF4A3;MAGOH;RBM8A	MLN51;DDX48, KIAA0111;MAGOHA;RBM8
741	NCOR-HDAC3 complex	Human	None	None	O15379;O60907;O75376;Q13227;Q9BZK7	8841;6907;9611;2874;79718	MI:0007-anti tag coimmunoprecipitation	GO:0006265;GO:0045892;GO:0032774;GO:0006476;GO:0007254;GO:0051276;GO:0005634	DNA topological change;negative regulation of DNA-templated transcription;RNA biosynthetic process;protein deacetylation;JNK cascade;chromosome organization;nucleus	10.01.09.05;11.02.03.04.03;11.02;14.07.04;30.01.05.01.02;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription repression;RNA synthesis;modification by acetylation, deacetylation;JNK cascade;organization of chromosome structure;nucleus	11931768	N-CoR-HDAC3 complex inhibits JNK activation through the associated GPS2 subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP-1 function.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone deacetylase 3;F-box-like/WD repeat-containing protein TBL1X;Nuclear receptor corepressor 1;G protein pathway suppressor 2;F-box-like/WD repeat-containing protein TBL1XR1	HDAC3;TBL1X;NCOR1;GPS2;TBL1XR1	None;TBL1;KIAA1047;None;IRA1 TBLR1
742	eIF3 complex (EIF3S6, EIF3S5, EIF3S4, EIF3S3, EIF3S6IP, EIF3S2, EIF3S9, EIF3S12,  EIF3S10, EIF3S8,  EIF3S1, EIF3S7)	Human	None	None	O00303;O15371;O15372;O75821;O75822;P55884;P60228;Q13347;Q14152;Q99613;Q9UBQ5;Q9Y262	8665;8664;8667;8666;8669;8662;3646;8668;8661;8663;27335;51386	MI:0004-affinity chromatography technology;MI:0019-coimmunoprecipitation	GO:0006413	translational initiation	12.04.01	translation initiation	14519125	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Eukaryotic translation initiation factor 3 subunit F;Eukaryotic translation initiation factor 3 subunit D;Eukaryotic translation initiation factor 3 subunit H;Eukaryotic translation initiation factor 3 subunit G;Eukaryotic translation initiation factor 3 subunit J;Eukaryotic translation initiation factor 3 subunit B;Eukaryotic translation initiation factor 3 subunit E;Eukaryotic translation initiation factor 3 subunit I;Eukaryotic translation initiation factor 3 subunit A;Eukaryotic translation initiation factor 3 subunit C;Eukaryotic translation initiation factor 3 subunit K;Eukaryotic translation initiation factor 3 subunit L	EIF3F;EIF3D;EIF3H;EIF3G;EIF3J;EIF3B;EIF3E;EIF3I;EIF3A;EIF3C;EIF3K;EIF3L	EIF3S5;EIF3S7;EIF3S3;EIF3S4;EIF3S1;EIF3S9;EIF3S6 INT6;EIF3S2 TRIP1;EIF3S10 KIAA0139;EIF3S8;EIF3S12;EIF3EIP EIF3S6IP
745	NCOR-SIN3-RPD3 complex	Human	None	MCF-7 cells	O75182;Q92769;Q96ST3;Q9Y618	23309;3066;25942;9612	MI:0006-anti bait coimmunoprecipitation	GO:0006265;GO:0045892;GO:0032774;GO:0006476;GO:0009755;GO:0051276;GO:0005634	DNA topological change;negative regulation of DNA-templated transcription;RNA biosynthetic process;protein deacetylation;hormone-mediated signaling pathway;chromosome organization;nucleus	10.01.09.05;11.02.03.04.03;11.02;14.07.04;30.01.09.08;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription repression;RNA synthesis;modification by acetylation, deacetylation;hormone mediated signal transduction;organization of chromosome structure;nucleus	9139820	The authors predict that the ligand-induced switch of heterodimeric nuclear receptors from repressor to activator functions involves the exchange of complexes containing histone deacetylases with those that have histone acetylase activity.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Paired amphipathic helix protein Sin3b;Histone deacetylase 2;Paired amphipathic helix protein Sin3a;Nuclear receptor corepressor 2	SIN3B;HDAC2;SIN3A;NCOR2	KIAA0700;None;None;CTG26
746	C/EBPalpha-HNF6 complex	Human	None	None	P49715;Q9UBC0	1050;3175	MI:0004-affinity chromatography technology;MI:0019-coimmunoprecipitation	GO:0045893;GO:0005634	positive regulation of DNA-templated transcription;nucleus	11.02.03.04.01;70.10	transcription activation;nucleus	16440369	Formation of the C/EBPalpha-HNF6 protein complex required the HNF6 cut domain and the C/EBPalpha activation domain (AD) 1/AD2 sequences. The C/EBPalpha-HNF6 protein complex stimulates recruitment of the CBP coactivator protein for expression of Foxa2.	None	None	Homo sapiens (Human);Homo sapiens (Human)	CCAAT/enhancer-binding protein alpha;Hepatocyte nuclear factor 6	CEBPA;ONECUT1	CEBP;HNF6 HNF6A
747	NCOR-SIN3-HDAC1 complex	Human	None	HL-60 cells	Q13547;Q96ST3;Q9Y618	3065;25942;9612	MI:0096-pull down	GO:0006265;GO:0045892;GO:0032774;GO:0006476;GO:0009755;GO:0051276;GO:0005634	DNA topological change;negative regulation of DNA-templated transcription;RNA biosynthetic process;protein deacetylation;hormone-mediated signaling pathway;chromosome organization;nucleus	10.01.09.05;11.02.03.04.03;11.02;14.07.04;30.01.09.08;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription repression;RNA synthesis;modification by acetylation, deacetylation;hormone mediated signal transduction;organization of chromosome structure;nucleus	9150137	N-CoR directly interact with mSin3A.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone deacetylase 1;Paired amphipathic helix protein Sin3a;Nuclear receptor corepressor 2	HDAC1;SIN3A;NCOR2	RPD3L1;None;CTG26
748	TRAF6-TAK1 complex	Human	None	None	O43318;Q9Y4K3	6885;7189	MI:0019-coimmunoprecipitation	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	30.05.01.18	transmembrane receptor protein serine/threonine kinase signalling pathways	16543409	During IL-1 signaling cascade a complex consisting of TRAF6, TAK1, TAB1, TAB2, and the two ubiquitin ligases Uev1A and Ubc13 is formed, phosphorylating TRAF6 and subsequently TAK1. TAK1 activation leads to activation of both NF{kappa}B and the MAPKs, followed by gene transcription. SOCS-3 (suppressor of cytokine signaling-3) inhibits IL-1 signal transduction by inhibiting ubiquitination of TRAF6, thus preventing association and activation of TAK1.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Mitogen-activated protein kinase kinase kinase 7;TNF receptor-associated factor 6	MAP3K7;TRAF6	TAK1;RNF85
749	MeCP2-SIN3A-HDAC complex	Human	None	HeLa cells	P51608;Q13547;Q92769;Q96ST3	4204;3065;3066;25942	MI:0096-pull down	GO:0006265;GO:0045892;GO:0006476;GO:0003677;GO:0051276;GO:0005634	DNA topological change;negative regulation of DNA-templated transcription;protein deacetylation;DNA binding;chromosome organization;nucleus	10.01.09.05;11.02.03.04.03;14.07.04;16.03.01;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription repression;modification by acetylation, deacetylation;DNA binding;organization of chromosome structure;nucleus	9620804	MeCp binds specifically to methylated DNA, thus linking two global mechanisms of gene regulation, DNA methylation and histone deacetylation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Methyl-CpG-binding protein 2;Histone deacetylase 1;Histone deacetylase 2;Paired amphipathic helix protein Sin3a	MECP2;HDAC1;HDAC2;SIN3A	None;RPD3L1;None;None
752	SMRT core complex	Human	None	HeLa nuclear extracts	O15379;O60907;Q9Y618	8841;6907;9612	MI:0006-anti bait coimmunoprecipitation;MI:0071-molecular sieving;MI:0226-ion exchange chromatography	GO:0006265;GO:0045892;GO:0006476;GO:0009755;GO:0051276;GO:0005634	DNA topological change;negative regulation of DNA-templated transcription;protein deacetylation;hormone-mediated signaling pathway;chromosome organization;nucleus	10.01.09.05;11.02.03.04.03;14.07.04;30.01.09.08;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription repression;modification by acetylation, deacetylation;hormone mediated signal transduction;organization of chromosome structure;nucleus	10944117	HDAC3 did not interact directly with TBL1. However, addition of SMRT to the mixture of HDAC3 and TBL1 allowed formation of a stable TBL1-SMRT-HDAC3 complex in vitro, suggesting that SMRT mediates the association of TBL1 and HDAC3 in a single complex in vivo. (PMID: 10809664)	None	Another subunit of the complex was found in the analysis, which has not been further characterized: SMRT-p37.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone deacetylase 3;F-box-like/WD repeat-containing protein TBL1X;Nuclear receptor corepressor 2	HDAC3;TBL1X;NCOR2	None;TBL1;CTG26
753	UTM-SGCE-DAG1-CAV1-NOS3 complex	Human	None	None	O43556;P29474;P46939;Q03135;Q14118	8910;4846;7402;857;1605	MI:0019-coimmunoprecipitation	GO:0030234;GO:0050790;GO:0061028	enzyme regulator activity;regulation of catalytic activity;establishment of endothelial barrier	18.02.01	enzymatic activity regulation / enzyme regulator	17127434	The authors propose that this utrophin associated protein complex (UAPC) in human umbilical vein endothelial cells (HUVECs) may play an important role in the regulation of vascular tone.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Epsilon-sarcoglycan;Nitric oxide synthase, endothelial;Utrophin;Caveolin-1;Dystroglycan 1	SGCE;NOS3;UTRN;CAV1;DAG1	ESG;None;DMDL DRP1;CAV;None
754	Exon junction complex (EIF4A3, MLN51, UPF3B, MAGOH, Y14)	Human	None	None	O15234;P38919;P61326;Q9BZI7;Q9Y5S9	22794;9775;4116;65109;9939	MI:0007-anti tag coimmunoprecipitation	GO:0043488;GO:0006417;GO:0003723;GO:0050658;GO:0051033;GO:0051169;GO:0005737;GO:0005634	regulation of mRNA stability;regulation of translation;RNA binding;RNA transport;RNA transmembrane transporter activity;nuclear transport;cytoplasm;nucleus	11.04.03.11;12.07;16.03.03;20.01.21;20.09.01;70.03;70.10	control of mRNA stability;translational control;RNA binding;RNA transport;nuclear transport;cytoplasm;nucleus	16209946	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein CASC3;Eukaryotic initiation factor 4A-III;Protein mago nashi homolog;Regulator of nonsense transcripts 3B;RNA-binding protein 8A	CASC3;EIF4A3;MAGOH;UPF3B;RBM8A	MLN51;DDX48, KIAA0111;MAGOHA;RENT3B, UPF3X;RBM8
755	Exon junction complex (EIF4A3, MLN51, UPF3B, MAGOH, Y14, PYM)	Human	None	None	O15234;P38919;P61326;Q9BRP8;Q9BZI7;Q9Y5S9	22794;9775;4116;84305;65109;9939	MI:0007-anti tag coimmunoprecipitation	GO:0043488;GO:0006417;GO:0003723;GO:0050658;GO:0051033;GO:0051169;GO:0005737;GO:0005634	regulation of mRNA stability;regulation of translation;RNA binding;RNA transport;RNA transmembrane transporter activity;nuclear transport;cytoplasm;nucleus	11.04.03.11;12.07;16.03.03;20.01.21;20.09.01;70.03;70.10	control of mRNA stability;translational control;RNA binding;RNA transport;nuclear transport;cytoplasm;nucleus	16209946	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein CASC3;Eukaryotic initiation factor 4A-III;Protein mago nashi homolog;Partner of Y14 and mago;Regulator of nonsense transcripts 3B;RNA-binding protein 8A	CASC3;EIF4A3;MAGOH;PYM1;UPF3B;RBM8A	MLN51;DDX48, KIAA0111;MAGOHA;PYM WIBG;RENT3B, UPF3X;RBM8
756	Prune-Gelsolin complex	Human	None	None	P06396;Q86TP1	2934;58497	MI:0004-affinity chromatography technology;MI:0019-coimmunoprecipitation	GO:0016477	cell migration	34.05.01	cell migration	17103319	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Gelsolin;Exopolyphosphatase PRUNE1	GSN;PRUNE1	None;PRUNE
757	Prune-GSK3beta complex	Human	None	None	P49841;Q86TP1	2932;58497	MI:0004-affinity chromatography technology;MI:0019-coimmunoprecipitation	GO:0016477	cell migration	34.05.01	cell migration	17103319	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Glycogen synthase kinase-3 beta;Exopolyphosphatase PRUNE1	GSK3B;PRUNE1	None;PRUNE
758	Prune/Nm23-H1 complex	Human	None	None	P15531;Q86TP1	4830;58497	MI:0045-experimental interaction detection	GO:0048870	cell motility	None	None	14998490	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Nucleoside diphosphate kinase A;Exopolyphosphatase PRUNE1	NME1;PRUNE1	NDPKA NM23;PRUNE
761	Apoptosis- and splicing-associated protein complex (SAP18, RNPS1, Acinus-S)	Human	ASAP-S complex	HeLa cells	O00422;Q15287;Q9UKV3-3	10284;10921;22985	MI:0004-affinity chromatography technology;MI:0006-anti bait coimmunoprecipitation	GO:0000398;GO:0006397;GO:0006915;GO:0005634	mRNA splicing, via spliceosome;mRNA processing;apoptotic process;nucleus	11.04.03;40.10.02;70.10	mRNA processing (splicing, 5'-, 3'-end processing);apoptosis (type I programmed cell death);nucleus	12665594	In vitro splicing assays suggest that the ASAP complexes function to repress splicing in vitro and that the ability of RNPS1 (and possibly Acinus-L) to activate splicing is overcome both when it is a component of ASAP and in the presence of the intact complex. In vitro assays using an apoptotic extract strongly indicate that ASAP complexes disassemble during apoptosis.	None	The ASAP complexes exist in at least two isoforms, termed  ASAP-L and ASAP-S, which are characterized by the presence of different  splice variants of Acinus ACIN1, ACIN1-L and ACIN1-S, respectively.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone deacetylase complex subunit SAP18;RNA-binding protein with serine-rich domain 1;Isoform 3 of Apoptotic chromatin condensation inducer in the nucleus	SAP18;RNPS1;ACIN1	None;LDC2;ACINUS KIAA0670
763	Y14-Magoh complex	Human	None	None	P61326;Q9Y5S9	4116;9939	MI:0029-cosedimentation through density gradient;MI:0055-fluorescent resonance energy transfer;MI:0114-x-ray crystallography	GO:0000398;GO:0006397;GO:0050658;GO:0051033;GO:0051169;GO:0005737;GO:0005634	mRNA splicing, via spliceosome;mRNA processing;RNA transport;RNA transmembrane transporter activity;nuclear transport;cytoplasm;nucleus	11.04.03;20.01.21;20.09.01;70.03;70.10	mRNA processing (splicing, 5'-, 3'-end processing);RNA transport;nuclear transport;cytoplasm;nucleus	12781131	Y14 and Magoh form an extremely stable heterodimer. Magoh binds with high affinity to the RNP motif RNA binding domain (RBD) of Y14 and completely masks its RNA binding surface.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Protein mago nashi homolog;RNA-binding protein 8A	MAGOH;RBM8A	MAGOHA;RBM8
764	Dysferlin-affixin complex	Human	None	striated muscle	O75923;Q9HBI1	8291;29780	MI:0019-coimmunoprecipitation;MI:0051-fluorescence technology	GO:0007009;GO:0007519;GO:0014706	plasma membrane organization;skeletal muscle tissue development;striated muscle tissue development	42.02;41.05.15;45.03.12.01	eukaryotic plasma membrane;myogenesis;striated muscle	15835269	The results suggest that affixin may participate in membrane repair with dysferlin.	DYSF is involved in Miyoshi myopathy (MM) and limb girdle muscular dystrophy type 2B (LGMD2B).	None	Homo sapiens (Human);Homo sapiens (Human)	Dysferlin;Beta-parvin	DYSF;PARVB	FER1L1;None
770	TREX complex	Human	None	HeLa cells	Q13769;Q13838;Q6I9Y2;Q86V81;Q86W42;Q8NI27;Q96FV9;Q96J01	8563;7919;80145;10189;79228;57187;9984;84321	MI:0007-anti tag coimmunoprecipitation	GO:0016363;GO:0016607;GO:0006405	nuclear matrix;nuclear speck;RNA export from nucleus	70.10.06;70.10.09	nuclear matrix;nuclear speckles	15998806	The TREX complex is recruited by the CBC complex to the 5-prime end of spliced RNAs and is involved in RNA export from the nucleus into the cytoplasm. The TREX complex contains the THO transcription elongation complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	THO complex subunit 5 homolog;Spliceosome RNA helicase DDX39B;THO complex subunit 7 homolog;THO complex subunit 4;THO complex subunit 6 homolog;THO complex subunit 2;THO complex subunit 1;THO complex subunit 3	THOC5;DDX39B;THOC7;ALYREF;THOC6;THOC2;THOC1;THOC3	C22orf19, KIAA0983;BAT1 UAP56;NIF3L1BP1;ALY BEF THOC4;WDR58;CXorf3;HPR1;None
771	NDPKA-AMPKalpha1 complex	Human	None	liver	P15531;Q13131	4830;5562	MI:0019-coimmunoprecipitation	GO:0005515;GO:0005737	protein binding;cytoplasm	16.01;70.03	protein binding;cytoplasm	16026327	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Nucleoside diphosphate kinase A;5'-AMP-activated protein kinase catalytic subunit alpha-1	NME1;PRKAA1	NDPKA NM23;AMPK1
772	EIF4A3-MLN51 complex	Human	eIF4AIII-Btz complex	None	O15234;P38919	22794;9775	MI:0071-molecular sieving;MI:0114-x-ray crystallography	GO:0043488	regulation of mRNA stability	11.04.03.11	control of mRNA stability	16923391	The 3.0 Angstroem resolution structure of the eIF4AIII-Btz subcomplex reveals a dramatic conformational change of the helicase domains as compared to EJC bound eIF4AIII. More generally, the authors propose that similarly to what observed for protein kinases, members of the DEAD-box family of proteins are likely to adopt a similar structure in their 'on' state (when bound to ATP and RNA) despite having different conformations in their 'off' states.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Protein CASC3;Eukaryotic initiation factor 4A-III	CASC3;EIF4A3	MLN51;DDX48, KIAA0111
774	THO complex	Human	None	None	Q13769;Q6I9Y2;Q86W42;Q8NI27;Q96FV9	8563;80145;79228;57187;9984	MI:0007-anti tag coimmunoprecipitation	GO:0003723;GO:0016607	RNA binding;nuclear speck	16.03.03;70.10.09	RNA binding;nuclear speckles	15998806	The human THO complex associates with spliced mRNA, but not with unspliced pre-mRNA in vitro. Transcription is not required for this recruitment. It was also shown that the human THO complex colocalizes with splicing factors in nuclear speckle domains in vivo. The TREX complex contains the THO transcription elongation complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	THO complex subunit 5 homolog;THO complex subunit 7 homolog;THO complex subunit 6 homolog;THO complex subunit 2;THO complex subunit 1	THOC5;THOC7;THOC6;THOC2;THOC1	C22orf19, KIAA0983;NIF3L1BP1;WDR58;CXorf3;HPR1
777	Exon junction complex	Human	EJC complex	COS cells	Q15287;Q86V81;Q8IYB3;Q9BZI7;Q9HAU5;Q9UBU9;Q9Y5S9	10921;10189;10250;65109;26019;10482;9939	MI:0019-coimmunoprecipitation	GO:0006401;GO:0003723;GO:0050658;GO:0051033;GO:0051169;GO:0005634	RNA catabolic process;RNA binding;RNA transport;RNA transmembrane transporter activity;nuclear transport;nucleus	01.03.16.01;16.03.03;20.01.21;20.09.01;70.10	RNA degradation;RNA binding;RNA transport;nuclear transport;nucleus	12093754	The exon junction complex (EJC) is a protein complex that assembles near exon-exon junctions of mRNAs as a result of splicing. EJC proteins play important roles in postsplicing events including mRNA export, cytoplasmic localization, and nonsense-mediated decay.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	RNA-binding protein with serine-rich domain 1;THO complex subunit 4;Serine/arginine repetitive matrix protein 1;Regulator of nonsense transcripts 3B;Regulator of nonsense transcripts 2;Nuclear RNA export factor 1;RNA-binding protein 8A	RNPS1;ALYREF;SRRM1;UPF3B;UPF2;NXF1;RBM8A	LDC2;ALY BEF THOC4;SRM160;RENT3B, UPF3X;KIAA1408, RENT2;TAP;RBM8
778	LARC complex (LCR-associated remodeling complex)	Human	None	None	O14497;O94776;O95983;O96019;P07910;P51532;P60709;Q09028;Q12824;Q13547;Q14839;Q8TAQ2;Q8WXI9;Q92769;Q92785;Q92922;Q92925;Q969G3;Q9UBB5	8289;9219;53615;86;3183;6597;60;5928;6598;3065;1108;6601;57459;3066;5977;6599;6603;6605;8932	MI:0004-affinity chromatography technology;MI:0091-chromatography technology	GO:0006265;GO:0003677;GO:0051276;GO:0005634	DNA topological change;DNA binding;chromosome organization;nucleus	10.01.09.05;16.03.01;42.10.03;70.10	DNA conformation modification (e.g. chromatin);DNA binding;organization of chromosome structure;nucleus	16217013	LARC binds to the hypersensitive 2 (HS2)-Maf recognition element (MARE) DNA in a sequence-specific manner and remodels nucleosomes.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	AT-rich interactive domain-containing protein 1A;Metastasis-associated protein MTA2;Methyl-CpG-binding domain protein 3;Actin-like protein 6A;Heterogeneous nuclear ribonucleoproteins C1/C2;Transcription activator BRG1;Actin, cytoplasmic 1;Histone-binding protein RBBP4;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1;Histone deacetylase 1;Chromodomain-helicase-DNA-binding protein 4;SWI/SNF complex subunit SMARCC2;Transcriptional repressor p66-beta;Histone deacetylase 2;Zinc finger protein ubi-d4;SWI/SNF complex subunit SMARCC1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1;Methyl-CpG-binding domain protein 2	ARID1A;MTA2;MBD3;ACTL6A;HNRNPC;SMARCA4;ACTB;RBBP4;SMARCB1;HDAC1;CHD4;SMARCC2;GATAD2B;HDAC2;DPF2;SMARCC1;SMARCD2;SMARCE1;MBD2	BAF250 BAF250A C1orf4 OSA1 SMARCF1;MTA1L1 PID;None;BAF53 BAF53A INO80K;HNRPC;BAF190A BRG1 SNF2B SNF2L4;None;RBAP48;BAF47, INI1, SNF5L1;RPD3L1;None;BAF170;KIAA1150;None;BAF45D REQ UBID4;BAF155;BAF60B;BAF57;None
781	URI complex (Unconventional prefoldin RPB5 Interactor)	Human	Prefoldin-like complex	None	O94763;P19388;P63208;Q13309;Q13616;Q9UHV9;Q9ULZ2;Q9Y230;Q9Y265	8725;5434;6500;6502;8454;5202;26228;10856;8607	MI:0006-anti bait coimmunoprecipitation;MI:0071-molecular sieving	GO:2001141;GO:0006355;GO:0042594;GO:0048015	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;response to starvation;phosphatidylinositol-mediated signaling	11.02.03.04;32.01.11	transcriptional control;nutrient starvation response	14615539	The URI complex participates in the regulation of nutrient-sensitive, TOR-dependent transcription programs.	None	Three other subunits of the complex were found in the analysis, which have not been further characterized: p42, p40, p10.At the time of annotation, the additional member PFD4-related protein of the protein complex was not found in the UniProt database.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Unconventional prefoldin RPB5 interactor 1;DNA-directed RNA polymerases I, II, and III subunit RPABC1;S-phase kinase-associated protein 1;S-phase kinase-associated protein 2;Cullin-1;Prefoldin subunit 2;Signal-transducing adaptor protein 1;RuvB-like 2;RuvB-like 1	URI1;POLR2E;SKP1;SKP2;CUL1;PFDN2;STAP1;RUVBL2;RUVBL1	C19orf2 NNX3 PPP1R19 RMP URI;None;EMC19 OCP2 SKP1A TCEB1L;FBXL1;None;PFD2;BRDG1;INO80J TIP48 TIP49B;INO80H NMP238 TIP49 TIP49A
783	ITCH-USP9X complex	Human	None	None	Q93008;Q96J02	8239;83737	MI:0004-affinity chromatography technology;MI:0019-coimmunoprecipitation;MI:0069-mass spectrometry studies of complexes	GO:0016579;GO:0005515	protein deubiquitination;protein binding	14.07.05;16.01	modification by ubiquitination, deubiquitination;protein binding	17038327	Interaction between Itch and FAM (USP9X) reverses Itch auto-ubiquitylation and protects the ligase from proteasomal degradation.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Probable ubiquitin carboxyl-terminal hydrolase FAF-X;E3 ubiquitin-protein ligase Itchy homolog	USP9X;ITCH	DFFRX FAM USP9;None
784	SURF complex	Human	ETF1-GSPT1-SMG1-UPF1 complex; SMG-1-UPF-ERF1-ERF3 complex (SURF)	HeLa cells	P15170;P62495;Q92900;Q96Q15	2935;2107;5976;23049	MI:0006-anti bait coimmunoprecipitation	GO:0000184;GO:0006449	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;regulation of translational termination	None	None	16452507	The SURF complex accumulated greatly when Upf2 or Y14 was depleted or the Upf2-binding region of Upf1 is mutated. SMG-1 forms a complex with Upf1, eRF1, and eRF3 in a Upf2- and Y14-independent manner.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Eukaryotic peptide chain release factor GTP-binding subunit ERF3A;Eukaryotic peptide chain release factor subunit 1;Regulator of nonsense transcripts 1;Serine/threonine-protein kinase SMG1	GSPT1;ETF1;UPF1;SMG1	ERF3A;ERF1, RF1, SUP45L1;KIAA0221 RENT1;ATX KIAA0421 LIP
785	Exon junction complex	Human	EJC complex	None	P38919;P61326;Q13838;Q15287;Q86V81;Q8IYB3;Q9BZI7;Q9Y5S9	9775;4116;7919;10921;10189;10250;65109;9939	MI:0019-coimmunoprecipitation	GO:0006401;GO:0003723;GO:0050658;GO:0051033;GO:0051169;GO:0005634	RNA catabolic process;RNA binding;RNA transport;RNA transmembrane transporter activity;nuclear transport;nucleus	01.03.16.01;16.03.03;20.01.21;20.09.01;70.10	RNA degradation;RNA binding;RNA transport;nuclear transport;nucleus	1473001	The exon junction complex (EJC) is a protein complex that assembles near exon-exon junctions of mRNAs as a result of splicing. EJC proteins play important roles in postsplicing events including mRNA export, cytoplasmic localization, and nonsense-mediated decay.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Eukaryotic initiation factor 4A-III;Protein mago nashi homolog;Spliceosome RNA helicase DDX39B;RNA-binding protein with serine-rich domain 1;THO complex subunit 4;Serine/arginine repetitive matrix protein 1;Regulator of nonsense transcripts 3B;RNA-binding protein 8A	EIF4A3;MAGOH;DDX39B;RNPS1;ALYREF;SRRM1;UPF3B;RBM8A	DDX48, KIAA0111;MAGOHA;BAT1 UAP56;LDC2;ALY BEF THOC4;SRM160;RENT3B, UPF3X;RBM8
786	MR-UBC9-SRC1 complex	Human	None	None	P08235;Q08209;Q15788	4306;5530;8648	MI:0019-coimmunoprecipitation;MI:0051-fluorescence technology	GO:2001141;GO:0006355;GO:0005634	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;nucleus	11.02.03.04;70.10	transcriptional control;nucleus	17105732	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mineralocorticoid receptor;Protein phosphatase 3 catalytic subunit alpha;Nuclear receptor coactivator 1	NR3C2;PPP3CA;NCOA1	MCR MLR;CALNA CNA;BHLHE74 SRC1
787	NuA4/Tip60-HAT complex B	Human	None	None	O96019;Q92993;Q9H2F5;Q9NPF5;Q9UBU8;Q9Y230;Q9Y265;Q9Y4A5	86;10524;80314;55929;10933;10856;8607;8295	MI:0007-anti tag coimmunoprecipitation	GO:0051276;GO:0006281;GO:0006265;GO:0003677;GO:0006974;GO:0005634;GO:0016573	chromosome organization;DNA repair;DNA topological change;DNA binding;cellular response to DNA damage stimulus;nucleus;histone acetylation	42.10.03;10.01.05.01;10.01.09.05;16.03.01;32.01.09;70.10	organization of chromosome structure;DNA repair;DNA conformation modification (e.g. chromatin);DNA binding;DNA damage response;nucleus	14966270	The NuA4 histone acetyltransferase (HAT) multisubunit complex is responsible for acetylation of histone H4 and H2A N-terminal tails in yeast. The NuA4/Tip60 HAT complex is highly conserved in eukaryotes playing primary roles in transcription, cellular response to DNA damage, and cell cycle control.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Actin-like protein 6A;Histone acetyltransferase KAT5;Enhancer of polycomb homolog 1;DNA methyltransferase 1-associated protein 1;Mortality factor 4-like protein 1;RuvB-like 2;RuvB-like 1;Transformation/transcription domain-associated protein	ACTL6A;KAT5;EPC1;DMAP1;MORF4L1;RUVBL2;RUVBL1;TRRAP	BAF53 BAF53A INO80K;HTATIP, TIP60;None;KIAA1425;MRG15;INO80J TIP48 TIP49B;INO80H NMP238 TIP49 TIP49A;PAF400
788	Exosome	Human	None	None	Q06265;Q13868;Q15024;Q5RKV6;Q96B26;Q9NPD3;Q9NQT4;Q9NQT5;Q9Y2L1;Q9Y3B2	5393;23404;23016;118460;11340;54512;56915;51010;22894;51013	MI:0019-coimmunoprecipitation	GO:0006401;GO:0003723;GO:0005737;GO:0005634	RNA catabolic process;RNA binding;cytoplasm;nucleus	01.03.16.01;16.03.03;70.03;70.10	RNA degradation;RNA binding;cytoplasm;nucleus	11719186	Inherently unstable mammalian mRNAs contain AU-rich elements (AREs) within their 3' untranslated regions. The mammalian exosome is required for rapid 3'-to-5' degradation of ARE-containing RNAs but not for poly(A) shortening. ARE recognition requires certain ARE binding proteins that can interact with the exosome and recruit it to unstable RNAs, thereby promoting their rapid degradation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Exosome complex component RRP45;Exosome complex component RRP4;Exosome complex component RRP42;Exosome complex component MTR3;Exosome complex component RRP43;Exosome complex component RRP41;Exosome complex component RRP46;Exosome complex component RRP40;Exosome complex exonuclease RRP44;Exosome complex component CSL4	EXOSC9;EXOSC2;EXOSC7;EXOSC6;EXOSC8;EXOSC4;EXOSC5;EXOSC3;DIS3;EXOSC1	PMSCL1;RRP4;KIAA0116 RRP42;MTR3;OIP2 RRP43;RRP41 SKI6;CML28 RRP46;RRP40;KIAA1008 RRP44;CSL4
789	Exosome	Human	None	None	Q01780;Q06265;Q13868;Q15024;Q5RKV6;Q96B26;Q9NPD3;Q9NQT4;Q9NQT5;Q9Y2L1;Q9Y3B2	5394;5393;23404;23016;118460;11340;54512;56915;51010;22894;51013	MI:0019-coimmunoprecipitation	GO:0006401;GO:0003723;GO:0005634	RNA catabolic process;RNA binding;nucleus	01.03.16.01;16.03.03;70.10	RNA degradation;RNA binding;nucleus	11719186	Inherently unstable mammalian mRNAs contain AU-rich elements (AREs) within their 3' untranslated regions. The mammalian exosome is required for rapid 3'-to-5' degradation of ARE-containing RNAs but not for poly(A) shortening. ARE recognition requires certain ARE binding proteins that can interact with the exosome and recruit it to unstable RNAs, thereby promoting their rapid degradation. The exosome complex containing PMSCL was only found in the nuclear complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Exosome component 10;Exosome complex component RRP45;Exosome complex component RRP4;Exosome complex component RRP42;Exosome complex component MTR3;Exosome complex component RRP43;Exosome complex component RRP41;Exosome complex component RRP46;Exosome complex component RRP40;Exosome complex exonuclease RRP44;Exosome complex component CSL4	EXOSC10;EXOSC9;EXOSC2;EXOSC7;EXOSC6;EXOSC8;EXOSC4;EXOSC5;EXOSC3;DIS3;EXOSC1	PMSCL PMSCL2 RRP6;PMSCL1;RRP4;KIAA0116 RRP42;MTR3;OIP2 RRP43;RRP41 SKI6;CML28 RRP46;RRP40;KIAA1008 RRP44;CSL4
790	DDB complex	Human	None	None	Q16531;Q92466	1642;1643	MI:0004-affinity chromatography technology;MI:0028-cosedimentation in solution	GO:0006281;GO:0003677;GO:0006974	DNA repair;DNA binding;cellular response to DNA damage stimulus	10.01.05.01;16.03.01;32.01.09	DNA repair;DNA binding;DNA damage response	16223728	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	DNA damage-binding protein 1;DNA damage-binding protein 2	DDB1;DDB2	XAP1;None
793	SNARE complex (CPLX1, SNAP25, STX1A, VAMP2)	Human	Complexin I complex	brain	O14810;P60880;P63027;Q16623	10815;6616;6844;6804	MI:0019-coimmunoprecipitation	GO:0030545;GO:0006906;GO:0048489;GO:0016079;GO:0005102;GO:0061025;GO:0031201	signaling receptor regulator activity;vesicle fusion;synaptic vesicle transport;synaptic vesicle exocytosis;signaling receptor binding;membrane fusion;SNARE complex	18.02.07;20.09.07.27;20.09.16.09.05;16.01.01	regulator of receptor activity;vesicle fusion;synaptic vesicle exocytosis;receptor binding	7553862	SNARE (N-ethylmaleimide-sensitive factor attachment protein receptor) complexes are responsible for membrane fusion in the secretory pathway.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Complexin-1;Synaptosomal-associated protein 25;Vesicle-associated membrane protein 2;Syntaxin-1A	CPLX1;SNAP25;VAMP2;STX1A	None;SNAP;SYB2;STX1
794	SNARE complex (CPLX2, SNAP25, STX1a, VAMP2)	Human	Complexin II complex	brain	P60880;P63027;Q16623;Q6PUV4	6616;6844;6804;10814	MI:0019-coimmunoprecipitation	GO:0030545;GO:0006906;GO:0048489;GO:0016079;GO:0005102;GO:0061025;GO:0031201	signaling receptor regulator activity;vesicle fusion;synaptic vesicle transport;synaptic vesicle exocytosis;signaling receptor binding;membrane fusion;SNARE complex	18.02.07;20.09.07.27;20.09.16.09.05;16.01.01	regulator of receptor activity;vesicle fusion;synaptic vesicle exocytosis;receptor binding	7553862	SNARE (N-ethylmaleimide-sensitive factor attachment protein receptor) complexes are responsible for membrane fusion in the secretory pathway.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Synaptosomal-associated protein 25;Vesicle-associated membrane protein 2;Syntaxin-1A;Complexin-2	SNAP25;VAMP2;STX1A;CPLX2	SNAP;SYB2;STX1;None
797	SNARE complex (SNAP23, STX11, VAMP2)	Human	None	HeLa cells; native human B lymphocytes	O00161;O75558;P63027	8773;8676;6844	MI:0018-two hybrid;MI:0019-coimmunoprecipitation	GO:0015031;GO:0006906;GO:0048489;GO:0016079;GO:0005768;GO:0061025;GO:0031201	protein transport;vesicle fusion;synaptic vesicle transport;synaptic vesicle exocytosis;endosome;membrane fusion;SNARE complex	20.01.10;20.09.07.27;20.09.16.09.05;70.22	protein transport;vesicle fusion;synaptic vesicle exocytosis;endosome	10036234	SNARE (N-ethylmaleimide-sensitive factor attachment protein receptor) complexes are responsible for membrane fusion in the secretory pathway.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Synaptosomal-associated protein 23;Syntaxin-11;Vesicle-associated membrane protein 2	SNAP23;STX11;VAMP2	None;None;SYB2
798	NuA4/Tip60-HAT complex A	Human	None	None	O95619;O96019;Q52LR7;Q92993;Q96L91;Q9H0E9;Q9H2F5;Q9HAF1;Q9NPF5;Q9NV56;Q9NXR8;Q9UBU8;Q9Y230;Q9Y265;Q9Y4A5	8089;86;26122;10524;57634;10902;80314;64769;55929;55257;54556;10933;10856;8607;8295	MI:0004-affinity chromatography technology	GO:0051276;GO:0006281;GO:0006265;GO:0003677;GO:0006974;GO:0005634;GO:0016573	chromosome organization;DNA repair;DNA topological change;DNA binding;cellular response to DNA damage stimulus;nucleus;histone acetylation	42.10.03;10.01.05.01;10.01.09.05;16.03.01;32.01.09;70.10	organization of chromosome structure;DNA repair;DNA conformation modification (e.g. chromatin);DNA binding;DNA damage response;nucleus	14966270	The NuA4 histone acetyltransferase (HAT) multisubunit complex is responsible for acetylation of histone H4 and H2A N-terminal tails in yeast. The NuA4/Tip60 HAT complex is highly conserved in eukaryotes playing primary roles in transcription, cellular response to DNA damage, and cell cycle control.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	YEATS domain-containing protein 4;Actin-like protein 6A;Enhancer of polycomb homolog 2;Histone acetyltransferase KAT5;E1A-binding protein p400;Bromodomain-containing protein 8;Enhancer of polycomb homolog 1;Chromatin modification-related protein MEAF6;DNA methyltransferase 1-associated protein 1;MRG/MORF4L-binding protein;Inhibitor of growth protein 3;Mortality factor 4-like protein 1;RuvB-like 2;RuvB-like 1;Transformation/transcription domain-associated protein	YEATS4;ACTL6A;EPC2;KAT5;EP400;BRD8;EPC1;MEAF6;DMAP1;MRGBP;ING3;MORF4L1;RUVBL2;RUVBL1;TRRAP	GAS41;BAF53 BAF53A INO80K;None;HTATIP, TIP60;CAGH32 KIAA1498 KIAA1818 TNRC12;SMAP, SMAP2;None;C1orf149 CENP-28 EAF6;KIAA1425;C20orf20;None;MRG15;INO80J TIP48 TIP49B;INO80H NMP238 TIP49 TIP49A;PAF400
799	DMAP1-associated complex	Human	None	None	O96019;Q15906;Q6ZRS2;Q96L91;Q9H0E9;Q9H2F5;Q9NPF5;Q9Y230;Q9Y265;Q9Y4A5	86;6944;10847;57634;10902;80314;55929;10856;8607;8295	MI:0004-affinity chromatography technology	GO:0051276;GO:0006281;GO:0006265;GO:0005634	chromosome organization;DNA repair;DNA topological change;nucleus	42.10.03;10.01.05.01;10.01.09.05;70.10	organization of chromosome structure;DNA repair;DNA conformation modification (e.g. chromatin);nucleus	14966270	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Actin-like protein 6A;Vacuolar protein sorting-associated protein 72 homolog;Helicase SRCAP;E1A-binding protein p400;Bromodomain-containing protein 8;Enhancer of polycomb homolog 1;DNA methyltransferase 1-associated protein 1;RuvB-like 2;RuvB-like 1;Transformation/transcription domain-associated protein	ACTL6A;VPS72;SRCAP;EP400;BRD8;EPC1;DMAP1;RUVBL2;RUVBL1;TRRAP	BAF53 BAF53A INO80K;TCFL1 YL1;KIAA0309;CAGH32 KIAA1498 KIAA1818 TNRC12;SMAP, SMAP2;None;KIAA1425;INO80J TIP48 TIP49B;INO80H NMP238 TIP49 TIP49A;PAF400
801	SNARE complex (SNAP23, STX2)	Human	None	human platelets	O00161;P32856	8773;2054	MI:0019-coimmunoprecipitation;MI:0047-far western blotting	GO:0006906;GO:0048489;GO:0016079;GO:0061025;GO:0031201	vesicle fusion;synaptic vesicle transport;synaptic vesicle exocytosis;membrane fusion;SNARE complex	20.09.07.27;20.09.16.09.05	vesicle fusion;synaptic vesicle exocytosis	10648404	SNARE (N-ethylmaleimide-sensitive factor attachment protein receptor) complexes are responsible for membrane fusion in the secretory pathway.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Synaptosomal-associated protein 23;Syntaxin-2	SNAP23;STX2	None;EPIM STX2A STX2B STX2C
803	BRG1-SIN3A-HDAC containing SWI/SNF remodeling complex I	Human	None	None	O14497;O14744;O96019;P51532;Q12824;Q8TAQ2;Q92769;Q92922;Q969G3;Q96GM5;Q96ST3	8289;10419;86;6597;6598;6601;3066;6599;6605;6602;25942	MI:0004-affinity chromatography technology;MI:0006-anti bait coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0006265;GO:2001141;GO:0006355;GO:0006476;GO:0006479;GO:0003677;GO:0051276;GO:0005634	DNA topological change;regulation of RNA biosynthetic process;regulation of DNA-templated transcription;protein deacetylation;protein methylation;DNA binding;chromosome organization;nucleus	10.01.09.05;11.02.03.04;14.07.04;14.07.09;16.03.01;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcriptional control;modification by acetylation, deacetylation;posttranslational modification of amino acids (e.g. hydroxylation, methylation);DNA binding;organization of chromosome structure;nucleus	14559996	The authors provide evidence, that PRMT5, mSin3A/HDAC2, and the Brg1-based hSWI/SNF complex are involved in cad transcriptional repression.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	AT-rich interactive domain-containing protein 1A;Protein arginine N-methyltransferase 5;Actin-like protein 6A;Transcription activator BRG1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1;SWI/SNF complex subunit SMARCC2;Histone deacetylase 2;SWI/SNF complex subunit SMARCC1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1;Paired amphipathic helix protein Sin3a	ARID1A;PRMT5;ACTL6A;SMARCA4;SMARCB1;SMARCC2;HDAC2;SMARCC1;SMARCE1;SMARCD1;SIN3A	BAF250 BAF250A C1orf4 OSA1 SMARCF1;HRMT1L5 IBP72 JBP1 SKB1;BAF53 BAF53A INO80K;BAF190A BRG1 SNF2B SNF2L4;BAF47, INI1, SNF5L1;BAF170;None;BAF155;BAF57;BAF60A;None
805	SNARE complex (SNAP23, STX4)	Human	t-SNARE	human DNA inserted into pQE-9 vector	O00161;Q12846	8773;6810	MI:0019-coimmunoprecipitation;MI:0040-electron microscopy	GO:0006906;GO:0048489;GO:0016079;GO:0061025;GO:1990927;GO:0031201	vesicle fusion;synaptic vesicle transport;synaptic vesicle exocytosis;membrane fusion;calcium ion regulated lysosome exocytosis;SNARE complex	20.09.07.27;20.09.16.09.05	vesicle fusion;synaptic vesicle exocytosis	10961877	SNARE (N-ethylmaleimide-sensitive factor attachment protein receptor) complexes are responsible for membrane fusion in the secretory pathway. 2 syntaxin t-SNAREs, syntaxin 2 and 4 localize to granules and open canalicular membranes and together with the general target membrane SNAP receptor (t-SNARE) protein SNAP-23 they appear to make up the heterodimeric t-SNAREs required for lysosome exocytosis.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Synaptosomal-associated protein 23;Syntaxin-4	SNAP23;STX4	None;STX4A
806	BRM-SIN3A-HDAC complex	Human	BRM-Sin3A-HDAC containing SWI/SNF remodeling complex	None	O14497;O14744;O96019;P51531;Q12824;Q8TAQ2;Q92769;Q92922;Q92925;Q969G3;Q96GM5;Q96ST3	8289;10419;86;6595;6598;6601;3066;6599;6603;6605;6602;25942	MI:0004-affinity chromatography technology;MI:0006-anti bait coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0006265;GO:2001141;GO:0006355;GO:0006476;GO:0006479;GO:0051276;GO:0005634	DNA topological change;regulation of RNA biosynthetic process;regulation of DNA-templated transcription;protein deacetylation;protein methylation;chromosome organization;nucleus	10.01.09.05;11.02.03.04;14.07.04;14.07.09;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcriptional control;modification by acetylation, deacetylation;posttranslational modification of amino acids (e.g. hydroxylation, methylation);organization of chromosome structure;nucleus	14559996	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	AT-rich interactive domain-containing protein 1A;Protein arginine N-methyltransferase 5;Actin-like protein 6A;Probable global transcription activator SNF2L2;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1;SWI/SNF complex subunit SMARCC2;Histone deacetylase 2;SWI/SNF complex subunit SMARCC1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1;Paired amphipathic helix protein Sin3a	ARID1A;PRMT5;ACTL6A;SMARCA2;SMARCB1;SMARCC2;HDAC2;SMARCC1;SMARCD2;SMARCE1;SMARCD1;SIN3A	BAF250 BAF250A C1orf4 OSA1 SMARCF1;HRMT1L5 IBP72 JBP1 SKB1;BAF53 BAF53A INO80K;BAF190B BRM SNF2A SNF2L2;BAF47, INI1, SNF5L1;BAF170;None;BAF155;BAF60B;BAF57;BAF60A;None
807	BRG1-associated complex	Human	BRG1 containing SWI/SNF remodeling complex	None	O14497;O14744;O96019;P51532;Q12824;Q8TAQ2;Q92922;Q969G3;Q96GM5	8289;10419;86;6597;6598;6601;6599;6605;6602	MI:0004-affinity chromatography technology;MI:0029-cosedimentation through density gradient	GO:0006265;GO:2001141;GO:0006355;GO:0003677;GO:0051276;GO:0005634	DNA topological change;regulation of RNA biosynthetic process;regulation of DNA-templated transcription;DNA binding;chromosome organization;nucleus	10.01.09.05;11.02.03.04;16.03.01;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcriptional control;DNA binding;organization of chromosome structure;nucleus	14559996	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	AT-rich interactive domain-containing protein 1A;Protein arginine N-methyltransferase 5;Actin-like protein 6A;Transcription activator BRG1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1;SWI/SNF complex subunit SMARCC2;SWI/SNF complex subunit SMARCC1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1	ARID1A;PRMT5;ACTL6A;SMARCA4;SMARCB1;SMARCC2;SMARCC1;SMARCE1;SMARCD1	BAF250 BAF250A C1orf4 OSA1 SMARCF1;HRMT1L5 IBP72 JBP1 SKB1;BAF53 BAF53A INO80K;BAF190A BRG1 SNF2B SNF2L4;BAF47, INI1, SNF5L1;BAF170;BAF155;BAF57;BAF60A
808	BRM-associated complex	Human	BRM containing SWI/SNF remodeling complex	None	O14497;O14744;O96019;P51531;Q12824;Q8TAQ2;Q92922;Q92925;Q969G3;Q96GM5	8289;10419;86;6595;6598;6601;6599;6603;6605;6602	MI:0004-affinity chromatography technology;MI:0029-cosedimentation through density gradient	GO:0006265;GO:2001141;GO:0006355;GO:0006479;GO:0003677;GO:0051276;GO:0005634	DNA topological change;regulation of RNA biosynthetic process;regulation of DNA-templated transcription;protein methylation;DNA binding;chromosome organization;nucleus	10.01.09.05;11.02.03.04;14.07.09;16.03.01;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcriptional control;posttranslational modification of amino acids (e.g. hydroxylation, methylation);DNA binding;organization of chromosome structure;nucleus	14559996	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	AT-rich interactive domain-containing protein 1A;Protein arginine N-methyltransferase 5;Actin-like protein 6A;Probable global transcription activator SNF2L2;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1;SWI/SNF complex subunit SMARCC2;SWI/SNF complex subunit SMARCC1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1	ARID1A;PRMT5;ACTL6A;SMARCA2;SMARCB1;SMARCC2;SMARCC1;SMARCD2;SMARCE1;SMARCD1	BAF250 BAF250A C1orf4 OSA1 SMARCF1;HRMT1L5 IBP72 JBP1 SKB1;BAF53 BAF53A INO80K;BAF190B BRM SNF2A SNF2L2;BAF47, INI1, SNF5L1;BAF170;BAF155;BAF60B;BAF57;BAF60A
809	eRF1-eRF3-GTP-Mg(2+) complex	Human	None	None	P15170;P62495	2935;2107	MI:0065-isothermal titration calorimetry	GO:0006415;GO:0000287;GO:0005525;GO:0007264;GO:0005737	translational termination;magnesium ion binding;GTP binding;small GTPase mediated signal transduction;cytoplasm	12.04.03;16.17.07;16.19.05;30.01.05.05.01;70.03	translation termination;magnesium binding;GTP binding;small GTPase mediated signal transduction;cytoplasm	16914449	eRF3 binds GDP independently of the presence or absence of eRF1 whereas GTP binds only to the eRF1-eRF3 complex. The authors suggest that the quaternary eRF1-eRF3-GTP-Mg2+ complex binds to the ribosomal pretermination complex.	None	Since the authors did not specify ERF3 , we used isoform ERF3A.	Homo sapiens (Human);Homo sapiens (Human)	Eukaryotic peptide chain release factor GTP-binding subunit ERF3A;Eukaryotic peptide chain release factor subunit 1	GSPT1;ETF1	ERF3A;ERF1, RF1, SUP45L1
811	FCP1-associated protein complex	Human	None	H1299 cells	O14744;P30876;P35269;P84090;Q15208;Q9BQA1;Q9Y5B0	10419;5431;2962;2079;11329;79084;9150	MI:0004-affinity chromatography technology	GO:0006354;GO:0005634	DNA-templated transcription elongation;nucleus	11.02.03.01.04;70.10	transcription elongation;nucleus	12560496	The authors suggest a putative role of FCP1 CTD-phosphatase in linking the transcription elongation with the splicing process.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein arginine N-methyltransferase 5;DNA-directed RNA polymerase II subunit RPB2;General transcription factor IIF subunit 1;Enhancer of rudimentary homolog;Serine/threonine-protein kinase 38;Methylosome protein 50;RNA polymerase II subunit A C-terminal domain phosphatase	PRMT5;POLR2B;GTF2F1;ERH;STK38;WDR77;CTDP1	HRMT1L5 IBP72 JBP1 SKB1;None;RAP74;None;NDR1;MEP50 WD45;FCP1
812	Upf complex (UPF1, UPF2, UPF3a)	Human	None	None	Q92900;Q9H1J1;Q9HAU5	5976;65110;26019	MI:0019-coimmunoprecipitation	GO:0006401;GO:0003723;GO:0005737;GO:0016363	RNA catabolic process;RNA binding;cytoplasm;nuclear matrix	01.03.16.01;16.03.03;70.03;70.10.06	RNA degradation;RNA binding;cytoplasm;nuclear matrix	11163187	Human Upf proteins target mRNA for nonsense-mediated decay when bound downstream of a termination codon. Nonsense-mediated decay (NMD) rids eukaryotic cells of aberrant mRNAs containing premature termination codons. These are discriminated from true termination codons by downstream cis-elements, such as exon-exon junctions.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Regulator of nonsense transcripts 1;Regulator of nonsense transcripts 3A;Regulator of nonsense transcripts 2	UPF1;UPF3A;UPF2	KIAA0221 RENT1;RENT3A UPF3;KIAA1408, RENT2
813	Upf complex (UPF1, UPF2, UPF3b)	Human	None	None	Q92900;Q9BZI7;Q9HAU5	5976;65109;26019	MI:0019-coimmunoprecipitation	GO:0006401;GO:0003723;GO:0005737;GO:0016363	RNA catabolic process;RNA binding;cytoplasm;nuclear matrix	01.03.16.01;16.03.03;70.03;70.10.06	RNA degradation;RNA binding;cytoplasm;nuclear matrix	11163187	Human Upf proteins target mRNA for nonsense-mediated decay when bound downstream of a termination codon. Nonsense-mediated decay (NMD) rids eukaryotic cells of aberrant mRNAs containing premature termination codons. These are discriminated from true termination codons by downstream cis-elements, such as exon-exon junctions.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Regulator of nonsense transcripts 1;Regulator of nonsense transcripts 3B;Regulator of nonsense transcripts 2	UPF1;UPF3B;UPF2	KIAA0221 RENT1;RENT3B, UPF3X;KIAA1408, RENT2
814	Postsplicing complex	Human	None	None	Q15287;Q92900;Q9BZI7;Q9H1J1;Q9HAU5;Q9UBU9;Q9Y5S9	10921;5976;65109;65110;26019;10482;9939	MI:0019-coimmunoprecipitation	GO:0006401;GO:0003723;GO:0016363	RNA catabolic process;RNA binding;nuclear matrix	01.03.16.01;16.03.03;70.10.06	RNA degradation;RNA binding;nuclear matrix	11546874	A final quality-control step in mRNA maturation is mRNA surveillance. This process detects mRNAs with truncated open reading frames and subjects them to nonsense-mediated mRNA decay (NMD). The protein RNPS1, a component of the postsplicing complex that is deposited 5' to exon-exon junctions, interacts with the evolutionarily conserved human Upf complex, a central component of NMD.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	RNA-binding protein with serine-rich domain 1;Regulator of nonsense transcripts 1;Regulator of nonsense transcripts 3B;Regulator of nonsense transcripts 3A;Regulator of nonsense transcripts 2;Nuclear RNA export factor 1;RNA-binding protein 8A	RNPS1;UPF1;UPF3B;UPF3A;UPF2;NXF1;RBM8A	LDC2;KIAA0221 RENT1;RENT3B, UPF3X;RENT3A UPF3;KIAA1408, RENT2;TAP;RBM8
815	MRIP-MBS-RHOA complex	Human	None	None	O14974;P61586;Q6WCQ1	4659;387;23164	MI:0019-coimmunoprecipitation	GO:0005515;GO:0030234;GO:0050790;GO:0065003	protein binding;enzyme regulator activity;regulation of catalytic activity;protein-containing complex assembly	16.01;18.02.01	protein binding;enzymatic activity regulation / enzyme regulator	14506264	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein phosphatase 1 regulatory subunit 12A;Transforming protein RhoA;Myosin phosphatase Rho-interacting protein	PPP1R12A;RHOA;MPRIP	MBS MYPT1;ARH12 ARHA RHO12;KIAA0864 MRIP RHOIP3
816	MRIP-RHOA complex	Human	None	None	P61586;Q6WCQ1	387;23164	MI:0096-pull down	GO:0005515	protein binding	16.01	protein binding	14506264	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Transforming protein RhoA;Myosin phosphatase Rho-interacting protein	RHOA;MPRIP	ARH12 ARHA RHO12;KIAA0864 MRIP RHOIP3
817	MRIP-MBS complex	Human	None	None	O14974;Q6WCQ1	4659;23164	MI:0096-pull down	GO:0005515	protein binding	16.01	protein binding	14506264	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Protein phosphatase 1 regulatory subunit 12A;Myosin phosphatase Rho-interacting protein	PPP1R12A;MPRIP	MBS MYPT1;KIAA0864 MRIP RHOIP3
819	20S methylosome-SmD complex	Human	None	None	O14744;P54105;P62314;P62318	10419;1207;6632;6634	MI:0004-affinity chromatography technology;MI:0029-cosedimentation through density gradient	GO:0006479;GO:0005737;GO:0065003	protein methylation;cytoplasm;protein-containing complex assembly	14.07.09;70.03	posttranslational modification of amino acids (e.g. hydroxylation, methylation);cytoplasm	11713266	PRMT5 and pICln bind only to unmethylated SMD1 and SMD3.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein arginine N-methyltransferase 5;Methylosome subunit pICln;Small nuclear ribonucleoprotein Sm D1;Small nuclear ribonucleoprotein Sm D3	PRMT5;CLNS1A;SNRPD1;SNRPD3	HRMT1L5 IBP72 JBP1 SKB1;CLCI ICLN;None;None
820	SNARE complex (SNAP23, STX6)	Human	None	human neutrophils from fresh heparinized human peripheral blood	O00161;O43752	8773;10228	MI:0019-coimmunoprecipitation;MI:0663-confocal microscopy	GO:0006906;GO:0048489;GO:0016079;GO:0061025;GO:0043312;GO:0031201	vesicle fusion;synaptic vesicle transport;synaptic vesicle exocytosis;membrane fusion;neutrophil degranulation;SNARE complex	20.09.07.27;20.09.16.09.05	vesicle fusion;synaptic vesicle exocytosis	11001914	SNARE (N-ethylmaleimide-sensitive factor attachment protein receptor) complexes are responsible for membrane fusion in the secretory pathway.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Synaptosomal-associated protein 23;Syntaxin-6	SNAP23;STX6	None;None
822	mRNA decay complex (UPF1, UPF2, UPF3B, DCP2, XRN1, XRN2, EXOSC2, EXOSC4, EXOSC10, PARN)	Human	None	None	O95453;Q01780;Q13868;Q8IU60;Q8IZH2;Q92900;Q9BZI7;Q9H0D6;Q9HAU5;Q9NPD3	5073;5394;23404;167227;54464;5976;65109;22803;26019;54512	MI:0019-coimmunoprecipitation	GO:0006401;GO:0003723;GO:0005737;GO:0005634	RNA catabolic process;RNA binding;cytoplasm;nucleus	01.03.16.01;16.03.03;70.03;70.10	RNA degradation;RNA binding;cytoplasm;nucleus	14527413	From experiments, it is concluded that nonsense-mediated mRNA decay (NMD) in mammalian cells degrades mRNAs from both 5' and 3' ends by recruiting decapping and 5'-->3' exonuclease activities as well as deadenylating and 3'-->5' exonuclease activities. All these activities are present within the mRNA decay complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Poly(A)-specific ribonuclease PARN;Exosome component 10;Exosome complex component RRP4;m7GpppN-mRNA hydrolase;5'-3' exoribonuclease 1;Regulator of nonsense transcripts 1;Regulator of nonsense transcripts 3B;5'-3' exoribonuclease 2;Regulator of nonsense transcripts 2;Exosome complex component RRP41	PARN;EXOSC10;EXOSC2;DCP2;XRN1;UPF1;UPF3B;XRN2;UPF2;EXOSC4	DAN;PMSCL PMSCL2 RRP6;RRP4;NUDT20;SEP1;KIAA0221 RENT1;RENT3B, UPF3X;None;KIAA1408, RENT2;RRP41 SKI6
824	Anti-SMN protein complex	Human	None	None	O14893;P14678;P57678;Q16637;Q9UHI6	8487;6628;50628;None;11218	MI:0006-anti bait coimmunoprecipitation	GO:0008380;GO:0005737;GO:0065003	RNA splicing;cytoplasm;protein-containing complex assembly	11.04.03.01;70.03	splicing;cytoplasm	11713266	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Gem-associated protein 2;Small nuclear ribonucleoprotein-associated proteins B and B';Gem-associated protein 4;Survival motor neuron protein;Probable ATP-dependent RNA helicase DDX20	GEMIN2;SNRPB;GEMIN4;SMN1;DDX20	SIP1;COD SNRPB1;None;SMN SMNT;DP103 GEMIN3
825	JBP1-pICln complex	Human	None	None	O14744;P14678;P54105	10419;6628;1207	MI:0006-anti bait coimmunoprecipitation	GO:0006479;GO:0005737;GO:0065003	protein methylation;cytoplasm;protein-containing complex assembly	14.07.09;70.03	posttranslational modification of amino acids (e.g. hydroxylation, methylation);cytoplasm	11713266	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein arginine N-methyltransferase 5;Small nuclear ribonucleoprotein-associated proteins B and B';Methylosome subunit pICln	PRMT5;SNRPB;CLNS1A	HRMT1L5 IBP72 JBP1 SKB1;COD SNRPB1;CLCI ICLN
826	PAR-3-VE-cadherin-beta-catenin complex	Human	None	HEK 293T cells	P33151;P35222;Q8TEW0	1003;1499;56288	MI:0019-coimmunoprecipitation	GO:0051211;GO:0007043;GO:0030054	anisotropic cell growth;cell-cell junction assembly;cell junction	40.01.03;42.06.04;70.06	directional cell growth (morphogenesis);intercellular junction (gap junction/adherens junction);cell junction	17057644	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cadherin-5;Catenin beta-1;Partitioning defective 3 homolog	CDH5;CTNNB1;PARD3	None;CTNNB;PAR3 PAR3A
828	TRPC1-STIM1-ORAI1 complex	Human	None	Salivary gland cells	P48995;Q13586;Q96D31	7220;6786;84876	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0005216;GO:0005886;GO:0002115;GO:0006816;GO:0051592	ion channel activity;plasma membrane;store-operated calcium entry;calcium ion transport;response to calcium ion	20.03.01.01;70.02	ion channels;eukaryotic plasma membrane / membrane attached	17224452	The results show that all three proteins are essential for generation of TRPC1-SOC channels (store-operated calcium channels). The dynamic assembly of a TRPC1-STIM1-Orai1 complex is involved in activation of Ca2+ entry.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Short transient receptor potential channel 1;Stromal interaction molecule 1;Calcium release-activated calcium channel protein 1	TRPC1;STIM1;ORAI1	TRP1;GOK;CRACM1 TMEM142A
829	PAR-6-VE-cadherin complex, endothelial	Human	PARD6A-VE-cadherin complex, endothelial	None	P33151;Q9NPB6	1003;50855	MI:0019-coimmunoprecipitation	GO:0051211;GO:0007043	anisotropic cell growth;cell-cell junction assembly	40.01.03;42.06.04	directional cell growth (morphogenesis);intercellular junction (gap junction/adherens junction)	17057644	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cadherin-5;Partitioning defective 6 homolog alpha	CDH5;PARD6A	None;PAR6A
831	PAR-6-PAR-3-VE-cadherin complex, endothelial	Human	PARD6A-PAR-3-VE-cadherin complex, endothelial	None	P33151;Q8TEW0;Q9NPB6	1003;56288;50855	MI:0019-coimmunoprecipitation	GO:0051211;GO:0007043	anisotropic cell growth;cell-cell junction assembly	40.01.03;42.06.04	directional cell growth (morphogenesis);intercellular junction (gap junction/adherens junction)	17057644	PAR-3 and PAR-6 are recruited independently to cell-cell contacts and the localization of PAR-6 at cell junctions requires fully matured cell-cell contacts.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cadherin-5;Partitioning defective 3 homolog;Partitioning defective 6 homolog alpha	CDH5;PARD3;PARD6A	None;PAR3 PAR3A;PAR6A
832	Anti-Sm protein complex	Human	None	None	O14744;O14893;P14678;P54105;P57678;Q16637;Q9UHI6	10419;8487;6628;1207;50628;None;11218	MI:0006-anti bait coimmunoprecipitation	GO:0006479;GO:0005737	protein methylation;cytoplasm	14.07.09;70.03	posttranslational modification of amino acids (e.g. hydroxylation, methylation);cytoplasm	11713266	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein arginine N-methyltransferase 5;Gem-associated protein 2;Small nuclear ribonucleoprotein-associated proteins B and B';Methylosome subunit pICln;Gem-associated protein 4;Survival motor neuron protein;Probable ATP-dependent RNA helicase DDX20	PRMT5;GEMIN2;SNRPB;CLNS1A;GEMIN4;SMN1;DDX20	HRMT1L5 IBP72 JBP1 SKB1;SIP1;COD SNRPB1;CLCI ICLN;None;SMN SMNT;DP103 GEMIN3
833	6S methyltransferase complex	Human	None	None	P54105;P62314;P62318	1207;6632;6634	MI:0029-cosedimentation through density gradient	GO:0005515;GO:0005737;GO:0065003	protein binding;cytoplasm;protein-containing complex assembly	16.01;70.03	protein binding;cytoplasm	11713266	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Methylosome subunit pICln;Small nuclear ribonucleoprotein Sm D1;Small nuclear ribonucleoprotein Sm D3	CLNS1A;SNRPD1;SNRPD3	CLCI ICLN;None;None
834	20S methylosome and RG-containing Sm protein complex	Human	None	None	O14744;P14678;P54105;P62314;P62316;P62318	10419;6628;1207;6632;6633;6634	MI:0029-cosedimentation through density gradient	GO:0008380;GO:0006479;GO:0005737	RNA splicing;protein methylation;cytoplasm	11.04.03.01;14.07.09;70.03	splicing;posttranslational modification of amino acids (e.g. hydroxylation, methylation);cytoplasm	11713266	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein arginine N-methyltransferase 5;Small nuclear ribonucleoprotein-associated proteins B and B';Methylosome subunit pICln;Small nuclear ribonucleoprotein Sm D1;Small nuclear ribonucleoprotein Sm D2;Small nuclear ribonucleoprotein Sm D3	PRMT5;SNRPB;CLNS1A;SNRPD1;SNRPD2;SNRPD3	HRMT1L5 IBP72 JBP1 SKB1;COD SNRPB1;CLCI ICLN;None;SNRPD1;None
835	6S methyltransferase and RG-containing Sm proteins complex	Human	None	None	P14678;P54105;P62304;P62306;P62308;P62314;P62316;P62318	6628;1207;6635;6636;6637;6632;6633;6634	MI:0029-cosedimentation through density gradient	GO:0008380;GO:0005737	RNA splicing;cytoplasm	11.04.03.01;70.03	splicing;cytoplasm	11713266	snRNPs, integral components of the pre-mRNA splicing machinery, consist of seven Sm proteins which assemble in the cytoplasm as a ring structure on the snRNAs U1, U2, U4, and U5. The survival motor neuron (SMN) protein, the spinal muscular atrophy disease gene product, is crucial for snRNP core particle assembly in vivo. Results indicate that methylation of Sm proteins by the methylosome directs Sm proteins to the SMN complex for assembly into snRNP core particles and suggest that the methylosome can regulate snRNP assembly.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Small nuclear ribonucleoprotein-associated proteins B and B';Methylosome subunit pICln;Small nuclear ribonucleoprotein E;Small nuclear ribonucleoprotein F;Small nuclear ribonucleoprotein G;Small nuclear ribonucleoprotein Sm D1;Small nuclear ribonucleoprotein Sm D2;Small nuclear ribonucleoprotein Sm D3	SNRPB;CLNS1A;SNRPE;SNRPF;SNRPG;SNRPD1;SNRPD2;SNRPD3	COD SNRPB1;CLCI ICLN;None;PBSCF;PBSCG;None;SNRPD1;None
836	20S methyltransferase core complex	Human	methylosome	None	O14744;P54105	10419;1207	MI:0004-affinity chromatography technology;MI:0029-cosedimentation through density gradient	GO:0006479;GO:0005515;GO:0005737;GO:0065003	protein methylation;protein binding;cytoplasm;protein-containing complex assembly	14.07.09;16.01;70.03	posttranslational modification of amino acids (e.g. hydroxylation, methylation);protein binding;cytoplasm	11713266	The  methylation of Sm proteins by the methylosome directs Sm proteins to the SMN complex for assembly into snRNP core particles and thus the methylosome can regulate snRNP assembly.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Protein arginine N-methyltransferase 5;Methylosome subunit pICln	PRMT5;CLNS1A	HRMT1L5 IBP72 JBP1 SKB1;CLCI ICLN
839	LIN9-BMYB complex	Human	None	None	P10244;Q5TKA1	4605;286826	MI:0019-coimmunoprecipitation	GO:0000278;GO:0051726	mitotic cell cycle;regulation of cell cycle	10.03.01.01;10.03.01	mitotic cell cycle;mitotic cell cycle and cell cycle control	17098733	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Myb-related protein B;Protein lin-9 homolog	MYBL2;LIN9	BMYB;BARA TGS
845	PCI-PSA-SCG2 complex	Human	None	None	P05154;P07288;P13521	5104;354;7857	MI:0401-biochemical	GO:0030163	protein catabolic process	14.13	protein/peptide degradation	17253189	The complex formation among PCI, PSA, and Sg is modulated by several factors in seminal plasma.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Plasma serine protease inhibitor;Prostate-specific antigen;Secretogranin-2	SERPINA5;KLK3;SCG2	PCI PLANH3 PROCI;APS;CHGC
846	RICH1/AMOT polarity complex, Flag-Rich1 precipitated	Human	None	epithelium	P47756;P52907;Q4VCS5;Q68EM7;Q8N3R9;Q8NI35;Q96B97;Q9Y5K6	832;829;154796;55114;64398;10207;30011;23607	MI:0007-anti tag coimmunoprecipitation;MI:0069-mass spectrometry studies of complexes	GO:0008104;GO:0005096;GO:0043547;GO:0007186;GO:0051211;GO:0009798;GO:0007043;GO:0030054	protein localization;GTPase activator activity;positive regulation of GTPase activity;G protein-coupled receptor signaling pathway;anisotropic cell growth;axis specification;cell-cell junction assembly;cell junction	18.01.03;18.02.01.01.01;30.05.02.24;40.01.03;41.05.19;42.06.04;70.06	regulation by localization;GTPase activator (GAP);G-protein coupled receptor signalling pathway;directional cell growth (morphogenesis);asymmetries and axis determination;intercellular junction (gap junction/adherens junction);cell junction	16678097	In an additional immunoblot the authors show that Par-3 and aPKC likely associate with Rich1 at lower levels than Pals1 and Patj since they were not identified by MS. The authors propose that Rich1 and Amot maintain TJ integrity by the coordinate regulation of Cdc42 and by linking specific components of the TJ to intracellular protein trafficking.	None	Since the authors did not specify F-actin-capping protein subunit alpha , we used isoform CAPZA1 .	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	F-actin-capping protein subunit beta;F-actin-capping protein subunit alpha-1;Angiomotin;Rho GTPase-activating protein 17;Protein PALS1;InaD-like protein;SH3 domain-containing kinase-binding protein 1;CD2-associated protein	CAPZB;CAPZA1;AMOT;ARHGAP17;PALS1;PATJ;SH3KBP1;CD2AP	None;None;KIAA1071;RICH1;MPP5;CIPP INADL;CIN85;None
847	RICH1-PAR3-aPKC polarity complex	Human	None	epithelium	P41743;Q68EM7;Q8TEW0	5584;55114;56288	MI:0007-anti tag coimmunoprecipitation	GO:0008104;GO:0005096;GO:0043547;GO:0007186;GO:0051211;GO:0007043;GO:0030054	protein localization;GTPase activator activity;positive regulation of GTPase activity;G protein-coupled receptor signaling pathway;anisotropic cell growth;cell-cell junction assembly;cell junction	18.01.03;18.02.01.01.01;30.05.02.24;40.01.03;42.06.04;70.06	regulation by localization;GTPase activator (GAP);G-protein coupled receptor signalling pathway;directional cell growth (morphogenesis);intercellular junction (gap junction/adherens junction);cell junction	16678097	Immunoblotting revealed aPKC and the 100 kDa isoform of Par-3, but not Par-6, in Rich1 immunoprecipitates. Par-3 and aPKC likely associate with Rich1 at lower levels than Pals1 and Patj since they were not identified by MS (see complex 846).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein kinase C iota type;Rho GTPase-activating protein 17;Partitioning defective 3 homolog	PRKCI;ARHGAP17;PARD3	DXS1179E;RICH1;PAR3 PAR3A
848	RICH1/AMOT polarity complex, Flag-Amot precipitated	Human	None	epithelium	O75970;Q4VCS5;Q5T2T1;Q68EM7;Q8IY63;Q8N3R9;Q8NI35;Q9Y2J4	8777;154796;143098;55114;154810;64398;10207;51421	MI:0007-anti tag coimmunoprecipitation	GO:0008104;GO:0005096;GO:0043547;GO:0007186;GO:0051211;GO:0009798;GO:0007043;GO:0030054	protein localization;GTPase activator activity;positive regulation of GTPase activity;G protein-coupled receptor signaling pathway;anisotropic cell growth;axis specification;cell-cell junction assembly;cell junction	18.01.03;18.02.01.01.01;30.05.02.24;40.01.03;41.05.19;42.06.04;70.06	regulation by localization;GTPase activator (GAP);G-protein coupled receptor signalling pathway;directional cell growth (morphogenesis);asymmetries and axis determination;intercellular junction (gap junction/adherens junction);cell junction	16678097	The authors suggest that Amot is a component of at least two complexes, only one of which contains Rich1.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Multiple PDZ domain protein;Angiomotin;MAGUK p55 subfamily member 7;Rho GTPase-activating protein 17;Angiomotin-like protein 1;Protein PALS1;InaD-like protein;Angiomotin-like protein 2	MPDZ;AMOT;MPP7;ARHGAP17;AMOTL1;PALS1;PATJ;AMOTL2	MUPP1;KIAA1071;None;RICH1;;MPP5;CIPP INADL;KIAA0989
860	DNMT1-EHMT2-PCNA complex	Human	DNMT1-G9a-PCNA complex	None	P12004;P26358;Q96KQ7	5111;1786;10919	MI:0019-coimmunoprecipitation	GO:0006260;GO:0006306;GO:0051276;GO:0005634;GO:0051567	DNA replication;DNA methylation;chromosome organization;nucleus;histone H3-K9 methylation	10.01.03;10.01.09.01;42.10.03;70.10	DNA synthesis and replication;DNA methylation;organization of chromosome structure;nucleus	17085482	DNMT1 and G9a are loaded onto the chromatin simultaneously in a ternary complex with loading factor PCNA during chromatin replication. Direct cooperation between DNMT1 and G9a provides a mechanism of coordinated DNA and H3K9 methylation during cell division.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Proliferating cell nuclear antigen;DNA;Histone-lysine N-methyltransferase EHMT2	PCNA;DNMT1;EHMT2	None;AIM CXXC9 DNMT;BAT8 C6orf30 G9A KMT1C NG36
862	DNMT1-EHMT2 complex	Human	DNMT1-G9a complex	None	P26358;Q96KQ7	1786;10919	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0006260;GO:0006306;GO:0000084;GO:0051276;GO:0005634;GO:0051567	DNA replication;DNA methylation;mitotic S phase;chromosome organization;nucleus;histone H3-K9 methylation	10.01.03;10.01.09.01;10.03.01.01.05;42.10.03;70.10	DNA synthesis and replication;DNA methylation;S phase of mitotic cell cycle;organization of chromosome structure;nucleus	17085482	Direct cooperation between DNMT1 and G9a provides a mechanism of coordinated DNA and H3K9 methylation during cell division. The complex of DNMT1 and G9a led to enhanced DNA and histone methylation of in vitro assembled chromatin substrates.	None	None	Homo sapiens (Human);Homo sapiens (Human)	DNA;Histone-lysine N-methyltransferase EHMT2	DNMT1;EHMT2	AIM CXXC9 DNMT;BAT8 C6orf30 G9A KMT1C NG36
867	TRAP-SMCC mediator complex	Human	None	None	A0JLT2;Q15528;Q15648;Q71SY5;Q96G25;Q9BUE0;Q9NPJ6;Q9NVC6;Q9NX70;Q9P086	219541;6837;5469;81857;112950;54797;29079;9440;55588;400569	MI:0004-affinity chromatography technology;MI:0029-cosedimentation through density gradient	GO:0045893;GO:0005515;GO:0005634	positive regulation of DNA-templated transcription;protein binding;nucleus	11.02.03.04.01;16.01;70.10	transcription activation;protein binding;nucleus	14638676	Several identical subunits appear in protein complexes like DRIP/ARC, CRSP, NAT, PC2, SMCC and Mediator, indicating that unique classes of transcription activators may share common sets or subsets of cofactors.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mediator of RNA polymerase II transcription subunit 19;Mediator of RNA polymerase II transcription subunit 22;Mediator of RNA polymerase II transcription subunit 1;Mediator of RNA polymerase II transcription subunit 25;Mediator of RNA polymerase II transcription subunit 8;Mediator of RNA polymerase II transcription subunit 18;Mediator of RNA polymerase II transcription subunit 4;Mediator of RNA polymerase II transcription subunit 17;Mediator of RNA polymerase II transcription subunit 29;Mediator of RNA polymerase II transcription subunit 11	MED19;MED22;MED1;MED25;MED8;MED18;MED4;MED17;MED29;MED11	LCMR1;SURF5;ARC205 CRSP1 CRSP200 DRIP205 DRIP230 PBP PPARBP PPARGBP RB18A TRAP220 TRIP2;ACID1 ARC92 PTOV2;None;None;ARC36 DRIP36 VDRIP;ARC77 CRSP6 DRIP77 DRIP80 TRAP80;IXL;None
871	BRAF53-BRCA2 complex	Human	None	None	O60341;P51587;Q13547;Q92769;Q96BD5;Q9P0W2;Q9UKL0	23028;675;3065;3066;51317;10362;23186	MI:0006-anti bait coimmunoprecipitation;MI:0071-molecular sieving	GO:0006281;GO:0006265;GO:0000278;GO:0045892;GO:0006476;GO:0003677;GO:0051276;GO:0030182;GO:0005634	DNA repair;DNA topological change;mitotic cell cycle;negative regulation of DNA-templated transcription;protein deacetylation;DNA binding;chromosome organization;neuron differentiation;nucleus	10.01.05.01;10.01.09.05;10.03.01.01;11.02.03.04.03;14.07.04;16.03.01;42.10.03;43.03.13;70.10	DNA repair;DNA conformation modification (e.g. chromatin);mitotic cell cycle;transcription repression;modification by acetylation, deacetylation;DNA binding;organization of chromosome structure;neuron;nucleus	11207365	Antibody microinjection experiments suggest a role for BRCA2/BRAF35 complex in modulation of cell cycle progression.	BRCA2 confers susceptibility to in breast cancer.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Lysine-specific histone demethylase 1A;Breast cancer type 2 susceptibility protein;Histone deacetylase 1;Histone deacetylase 2;PHD finger protein 21A;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related;REST corepressor 1	KDM1A;BRCA2;HDAC1;HDAC2;PHF21A;HMG20B;RCOR1	AOF2 KDM1 KIAA0601 LSD1;FACD FANCD1;RPD3L1;None;BHC80 KIAA1696;BRAF35 HMGX2 HMGXB2 SMARCE1R;KIAA0071 RCOR
873	SNARE complex (STX1A, SNAP29)	Human	None	brain	O95721;Q16623	9342;6804	MI:0018-two hybrid;MI:0019-coimmunoprecipitation;MI:0047-far western blotting	GO:0006906;GO:0048489;GO:0016079;GO:0031201;GO:0061025	vesicle fusion;synaptic vesicle transport;synaptic vesicle exocytosis;SNARE complex;membrane fusion	20.09.07.27;20.09.16.09.05	vesicle fusion;synaptic vesicle exocytosis	11707603	SNARE (N-ethylmaleimide-sensitive factor attachment protein receptor) complexes are responsible for membrane fusion in the secretory pathway. SNAP-29 is a general SNARE protein that inhibits SNARE disassembly and is implicated in synaptic transmission.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Synaptosomal-associated protein 29;Syntaxin-1A	SNAP29;STX1A	None;STX1
874	SNARE complex (STX6, VAMP3, VAMP4, VAMP8)	Human	None	HeLa cells	O43752;O75379;Q15836;Q9BV40	10228;8674;9341;8673	MI:0019-coimmunoprecipitation;MI:0040-electron microscopy	GO:0006906;GO:0048489;GO:0016079;GO:0061025;GO:0031201	vesicle fusion;synaptic vesicle transport;synaptic vesicle exocytosis;membrane fusion;SNARE complex	20.09.07.27;20.09.16.09.05	vesicle fusion;synaptic vesicle exocytosis	11839770	SNARE (N-ethylmaleimide-sensitive factor attachment protein receptor) complexes are responsible for membrane fusion in the secretory pathway.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Syntaxin-6;Vesicle-associated membrane protein 4;Vesicle-associated membrane protein 3;Vesicle-associated membrane protein 8	STX6;VAMP4;VAMP3;VAMP8	None;None;SYB3;None
875	SNARE complex (STX16, VAMP3, VAMP4)	Human	None	HeLa cells	O14662;O75379;Q15836	8675;8674;9341	MI:0019-coimmunoprecipitation;MI:0040-electron microscopy	GO:0006906;GO:0048489;GO:0016079;GO:0061025;GO:0031201	vesicle fusion;synaptic vesicle transport;synaptic vesicle exocytosis;membrane fusion;SNARE complex	20.09.07.27;20.09.16.09.05	vesicle fusion;synaptic vesicle exocytosis	11839770	SNARE (N-ethylmaleimide-sensitive factor attachment protein receptor) complexes are responsible for membrane fusion in the secretory pathway.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Syntaxin-16;Vesicle-associated membrane protein 4;Vesicle-associated membrane protein 3	STX16;VAMP4;VAMP3	None;None;SYB3
876	SNARE complex (STX6, VAMP3, VTI1A)	Human	None	HeLa cells	O43752;Q15836;Q96AJ9	10228;9341;143187	MI:0019-coimmunoprecipitation;MI:0040-electron microscopy	GO:0006906;GO:0048489;GO:0016079;GO:0061025;GO:0031201	vesicle fusion;synaptic vesicle transport;synaptic vesicle exocytosis;membrane fusion;SNARE complex	20.09.07.27;20.09.16.09.05	vesicle fusion;synaptic vesicle exocytosis	11839770	SNARE (N-ethylmaleimide-sensitive factor attachment protein receptor) complexes are responsible for membrane fusion in the secretory pathway.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Syntaxin-6;Vesicle-associated membrane protein 3;Vesicle transport through interaction with t-SNAREs homolog 1A	STX6;VAMP3;VTI1A	None;SYB3;None
877	SNARE complex (STX6, STX16, VAMP4, VTI1a, VTI1b)	Human	None	HeLa cells	O14662;O43752;O75379;Q96AJ9;Q9UEU0	8675;10228;8674;143187;10490	MI:0019-coimmunoprecipitation;MI:0040-electron microscopy	GO:0006906;GO:0048489;GO:0016079;GO:0061025;GO:0031201	vesicle fusion;synaptic vesicle transport;synaptic vesicle exocytosis;membrane fusion;SNARE complex	20.09.07.27;20.09.16.09.05	vesicle fusion;synaptic vesicle exocytosis	11839770	SNARE (N-ethylmaleimide-sensitive factor attachment protein receptor) complexes are responsible for membrane fusion in the secretory pathway.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Syntaxin-16;Syntaxin-6;Vesicle-associated membrane protein 4;Vesicle transport through interaction with t-SNAREs homolog 1A;Vesicle transport through interaction with t-SNAREs homolog 1B	STX16;STX6;VAMP4;VTI1A;VTI1B	None;None;None;None;VTI1 VTI1L VTI1L1 VTI2
878	PKA (RII-alpha and RII-beta)-AKAP5-ADRB1 complex	Human	None	HEK-293 cells	P08588;P13861;P24588;P31323	153;5576;9495;5577	MI:0019-coimmunoprecipitation;MI:0055-fluorescent resonance energy transfer	GO:0007186;GO:0001881;GO:0010737	G protein-coupled receptor signaling pathway;receptor recycling;protein kinase A signaling	30.05.02.24	G-protein coupled receptor signalling pathway	16940053	AKAP79 provides PKA to phosphorylate the beta(1)-AR and thereby dictate the recycling and resensitization itineraries of the beta(1)-AR.	ADRB1 is involved in hypertension and heart failure.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Beta-1 adrenergic receptor;cAMP-dependent protein kinase type II-alpha regulatory subunit;A-kinase anchor protein 5;cAMP-dependent protein kinase type II-beta regulatory subunit	ADRB1;PRKAR2A;AKAP5;PRKAR2B	ADRB1R, B1AR;PKR2, PRKAR2;AKAP79;None
886	MTA1 complex	Human	None	None	O95983;Q09028;Q13330;Q13547;Q16576;Q92769	53615;5928;9112;3065;5931;3066	MI:0004-affinity chromatography technology;MI:0091-chromatography technology	GO:0006265;GO:0045892;GO:0006476;GO:0009755;GO:0051276;GO:0005634	DNA topological change;negative regulation of DNA-templated transcription;protein deacetylation;hormone-mediated signaling pathway;chromosome organization;nucleus	10.01.09.05;11.02.03.04.03;14.07.04;30.01.09.08;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription repression;modification by acetylation, deacetylation;hormone mediated signal transduction;organization of chromosome structure;nucleus	12920132	None	MTA1 is involved in metastasis or cancer formation.	Several other subunits of the complex were found in the analysis, which have not been further characterized: p68, p66 and three so-called MTA1-associated proteins.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Methyl-CpG-binding domain protein 3;Histone-binding protein RBBP4;Metastasis-associated protein MTA1;Histone deacetylase 1;Histone-binding protein RBBP7;Histone deacetylase 2	MBD3;RBBP4;MTA1;HDAC1;RBBP7;HDAC2	None;RBAP48;None;RPD3L1;RBAP46;None
888	MTA2 complex	Human	None	None	O94776;O95983;Q09028;Q13547;Q14839;Q16576;Q92769;Q96ST3	9219;53615;5928;3065;1108;5931;3066;25942	MI:0004-affinity chromatography technology;MI:0091-chromatography technology	GO:0006265;GO:0045892;GO:0032774;GO:0051276;GO:0005634;GO:0016575	DNA topological change;negative regulation of DNA-templated transcription;RNA biosynthetic process;chromosome organization;nucleus;histone deacetylation	10.01.09.05;11.02.03.04.03;11.02;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription repression;RNA synthesis;organization of chromosome structure;nucleus	12920132	Since MTA2 is not involved in metastasis or cancer formation, the authors suggest a housekeeping role of the MTA2 complex.	None	Since the authors did not specify SIN3, we used SIN3A.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Metastasis-associated protein MTA2;Methyl-CpG-binding domain protein 3;Histone-binding protein RBBP4;Histone deacetylase 1;Chromodomain-helicase-DNA-binding protein 4;Histone-binding protein RBBP7;Histone deacetylase 2;Paired amphipathic helix protein Sin3a	MTA2;MBD3;RBBP4;HDAC1;CHD4;RBBP7;HDAC2;SIN3A	MTA1L1 PID;None;RBAP48;RPD3L1;None;RBAP46;None;None
889	MTA1-HDAC core complex	Human	None	None	Q09028;Q13330;Q13547;Q16576;Q92769	5928;9112;3065;5931;3066	MI:0004-affinity chromatography technology;MI:0091-chromatography technology	GO:0006265;GO:0045892;GO:0006476;GO:0009755;GO:0051276;GO:0005634	DNA topological change;negative regulation of DNA-templated transcription;protein deacetylation;hormone-mediated signaling pathway;chromosome organization;nucleus	10.01.09.05;11.02.03.04.03;14.07.04;30.01.09.08;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription repression;modification by acetylation, deacetylation;hormone mediated signal transduction;organization of chromosome structure;nucleus	12920132	None	MTA1 is involved in metastasis or cancer formation.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone-binding protein RBBP4;Metastasis-associated protein MTA1;Histone deacetylase 1;Histone-binding protein RBBP7;Histone deacetylase 2	RBBP4;MTA1;HDAC1;RBBP7;HDAC2	RBAP48;None;RPD3L1;RBAP46;None
895	hMediator complex (MED23, CDK8, CCNC, MED7)	Human	None	None	O43513;P24863;P49336;Q9ULK4	9443;892;1024;9439	MI:0006-anti bait coimmunoprecipitation;MI:0071-molecular sieving;MI:0226-ion exchange chromatography	GO:0045893;GO:0005515;GO:0005634	positive regulation of DNA-templated transcription;protein binding;nucleus	11.02.03.04.01;16.01;70.10	transcription activation;protein binding;nucleus	10353252	The high-molecular-mass mammalian Mediator complexes have many subunits in common. However, their reported subunit compositions are not identical (PMID:10838567).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mediator of RNA polymerase II transcription subunit 7;Cyclin-C;Cyclin-dependent kinase 8;Mediator of RNA polymerase II transcription subunit 23	MED7;CCNC;CDK8;MED23	ARC34 CRSP9;None;None;ARC130 CRSP3 DRIP130 KIAA1216 SUR2
896	hMediator complex (MED23, CDK8, CCNC)	Human	None	None	P24863;P49336;Q9ULK4	892;1024;9439	MI:0006-anti bait coimmunoprecipitation;MI:0071-molecular sieving	GO:0045893;GO:0005515;GO:0005634	positive regulation of DNA-templated transcription;protein binding;nucleus	11.02.03.04.01;16.01;70.10	transcription activation;protein binding;nucleus	11416138	The high-molecular-mass mammalian Mediator complexes have many subunits in common. However, their reported subunit compositions are not identical (PMID:10838567).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cyclin-C;Cyclin-dependent kinase 8;Mediator of RNA polymerase II transcription subunit 23	CCNC;CDK8;MED23	None;None;ARC130 CRSP3 DRIP130 KIAA1216 SUR2
897	CDK8-CyclinC-Mediator complex	Human	None	None	P24863;P49336	892;1024	MI:0006-anti bait coimmunoprecipitation;MI:0071-molecular sieving	GO:0045892;GO:0006468;GO:0005634;GO:0036211	negative regulation of DNA-templated transcription;protein phosphorylation;nucleus;protein modification process	11.02.03.04.03;14.07.03;70.10	transcription repression;modification by phosphorylation, dephosphorylation, autophosphorylation;nucleus	11416138	It has been shown hat CDK8 phosphorylates the cyclin H subunit of TFIIH and inhibits its function in transcription (PMID:10993082). This explains, why the CDK8-CyclinC-Mediator complex inhibits basal and activated transcription.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cyclin-C;Cyclin-dependent kinase 8	CCNC;CDK8	None;None
898	Mediator complex 1	Human	High-molecular-mass Mediator complex 1; 2MDa Mediator complex 1	None	O60244;O75586;P24863;P49336;Q9ULK4	9282;10001;892;1024;9439	MI:0006-anti bait coimmunoprecipitation;MI:0071-molecular sieving	GO:0045893;GO:0005515;GO:0051090;GO:0005634	positive regulation of DNA-templated transcription;protein binding;regulation of DNA-binding transcription factor activity;nucleus	11.02.03.04.01;16.01;18.02.09;70.10	transcription activation;protein binding;regulator of transcription factor;nucleus	11416138	Regulation of transcription by RNA polymerase II (Pol II) is controlled by specific combinations of sequence-specific, DNA binding regulatory transcription factors (TFs) bound to a gene's promoter and enhancer regions. These TFs interact with several multiprotein complexes that remodel the chromatin context of the promoter, integrate signals from multiple TFs to control the frequency of transcription initiation, and regulate the efficiency of transcription elongation. One such complex is the Mediator, an ~2-megadalton complex of 20 to 30 subunits that is believed to function as a molecular bridge by simultaneously interacting with both DNA-bound TFs and Pol II. Several identical subunits appear in protein complexes like DRIP/ARC, CRSP, NAT, PC2, SMCC and Mediator, indicating that unique classes of transcription activators may share common sets or subsets of cofactors.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mediator of RNA polymerase II transcription subunit 14;Mediator of RNA polymerase II transcription subunit 6;Cyclin-C;Cyclin-dependent kinase 8;Mediator of RNA polymerase II transcription subunit 23	MED14;MED6;CCNC;CDK8;MED23	ARC150 CRSP2 CXorf4 DRIP150 EXLM1 RGR1 TRAP170;ARC33;None;None;ARC130 CRSP3 DRIP130 KIAA1216 SUR2
900	Mediator complex 2	Human	High-molecular-mass Mediator complex 2; 2MDa Mediator complex 2	None	O60244;O75586;Q9ULK4	9282;10001;9439	MI:0006-anti bait coimmunoprecipitation;MI:0071-molecular sieving	GO:0045893;GO:0005515;GO:0051090;GO:0005634	positive regulation of DNA-templated transcription;protein binding;regulation of DNA-binding transcription factor activity;nucleus	11.02.03.04.01;16.01;18.02.09;70.10	transcription activation;protein binding;regulator of transcription factor;nucleus	11416138	Regulation of transcription by RNA polymerase II (Pol II) is controlled by specific combinations of sequence-specific, DNA binding regulatory transcription factors (TFs) bound to a gene's promoter and enhancer regions. These TFs interact with several multiprotein complexes that remodel the chromatin context of the promoter, integrate signals from multiple TFs to control the frequency of transcription initiation, and regulate the efficiency of transcription elongation. One such complex is the Mediator, an ~2-megadalton complex of 20 to 30 subunits that is believed to function as a molecular bridge by simultaneously interacting with both DNA-bound TFs and Pol II. Several identical subunits appear in protein complexes like DRIP/ARC, CRSP, NAT, PC2, SMCC and Mediator, indicating that unique classes of transcription activators may share common sets or subsets of cofactors.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mediator of RNA polymerase II transcription subunit 14;Mediator of RNA polymerase II transcription subunit 6;Mediator of RNA polymerase II transcription subunit 23	MED14;MED6;MED23	ARC150 CRSP2 CXorf4 DRIP150 EXLM1 RGR1 TRAP170;ARC33;ARC130 CRSP3 DRIP130 KIAA1216 SUR2
903	RET-Rai complex	Human	None	None	P07949;Q92529	5979;53358	MI:0019-coimmunoprecipitation	GO:0007166	cell surface receptor signaling pathway	30.05	transmembrane signal transduction	15940252	RAI protein forms complexes with two variants of RET oncoprotein: MEN2A and PTC.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Proto-oncogene tyrosine-protein kinase receptor Ret;SHC-transforming protein 3	RET;SHC3	CDHF12 CDHR16 PTC RET51;NSHC SHCC
904	SHC3-GAB1 complex	Human	None	None	Q13480;Q92529	2549;53358	MI:0019-coimmunoprecipitation	GO:0007166	cell surface receptor signaling pathway	30.05	transmembrane signal transduction	15940252	RAI protein forms complexes with two variants of RET oncoprotein: MEN2A and PTC.	None	None	Homo sapiens (Human);Homo sapiens (Human)	GRB2-associated-binding protein 1;SHC-transforming protein 3	GAB1;SHC3	None;NSHC SHCC
905	KIF3A/B-PAR-3-aPKC-PAR-6 complex	Human	None	COS cells	O15066;P41743;Q8TEW0;Q9NPB6;Q9Y496	9371;5584;56288;50855;11127	MI:0007-anti tag coimmunoprecipitation	GO:0022008;GO:0048699;GO:0030182;GO:0030010	neurogenesis;generation of neurons;neuron differentiation;establishment of cell polarity	41.05.13;43.03.13	neurogenesis;neuron	15048131	The results indicate that PAR-3 interacts with KIF3 in vivo and that aPKC associates with KIF3 through its interaction with PAR-3.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Kinesin-like protein KIF3B;Protein kinase C iota type;Partitioning defective 3 homolog;Partitioning defective 6 homolog alpha;Kinesin-like protein KIF3A	KIF3B;PRKCI;PARD3;PARD6A;KIF3A	KIAA0359;DXS1179E;PAR3 PAR3A;PAR6A;KIF3
909	ARC92-Mediator complex	Human	A-Med complex	None	O43513;O60244;O75586;O95402;P49336;Q15648;Q71SY5;Q93074;Q96RN5;Q9NVC6;Q9UHV7;Q9ULK4;Q9Y2X0	9443;9282;10001;9441;1024;5469;81857;9968;51586;9440;9969;9439;10025	MI:0006-anti bait coimmunoprecipitation	GO:0045893;GO:0005515;GO:0051090;GO:0005634	positive regulation of DNA-templated transcription;protein binding;regulation of DNA-binding transcription factor activity;nucleus	11.02.03.04.01;16.01;18.02.09;70.10	transcription activation;protein binding;regulator of transcription factor;nucleus	14657022	Experiemts show that the transcription coactivator ARC is required for SREBP (sterol regulatory element binding protein) control of cholesterol and lipid homeostasis. Several identical subunits appear in protein complexes like DRIP/ARC, CRSP, NAT, PC2, SMCC and Mediator, indicating that unique classes of transcription activators may share common sets or subsets of cofactors.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mediator of RNA polymerase II transcription subunit 7;Mediator of RNA polymerase II transcription subunit 14;Mediator of RNA polymerase II transcription subunit 6;Mediator of RNA polymerase II transcription subunit 26;Cyclin-dependent kinase 8;Mediator of RNA polymerase II transcription subunit 1;Mediator of RNA polymerase II transcription subunit 25;Mediator of RNA polymerase II transcription subunit 12;Mediator of RNA polymerase II transcription subunit 15;Mediator of RNA polymerase II transcription subunit 17;Mediator of RNA polymerase II transcription subunit 13;Mediator of RNA polymerase II transcription subunit 23;Mediator of RNA polymerase II transcription subunit 16	MED7;MED14;MED6;MED26;CDK8;MED1;MED25;MED12;MED15;MED17;MED13;MED23;MED16	ARC34 CRSP9;ARC150 CRSP2 CXorf4 DRIP150 EXLM1 RGR1 TRAP170;ARC33;ARC70 CRSP7;None;ARC205 CRSP1 CRSP200 DRIP205 DRIP230 PBP PPARBP PPARGBP RB18A TRAP220 TRIP2;ACID1 ARC92 PTOV2;ARC240 CAGH45 HOPA KIAA0192 TNRC11 TRAP230;ARC105 CTG7A PCQAP TIG1 TNRC7;ARC77 CRSP6 DRIP77 DRIP80 TRAP80;ARC250 KIAA0593 THRAP1 TRAP240;ARC130 CRSP3 DRIP130 KIAA1216 SUR2;DRIP92 THRAP5
910	CRSP-Mediator 2 complex	Human	CRSP-Med 2 complex	None	O43513;O60244;O75448;O75586;Q96RN5;Q9BUE0;Q9NPJ6;Q9NVC6;Q9ULK4;Q9Y2X0	9443;9282;9862;10001;51586;54797;29079;9440;9439;10025	MI:0004-affinity chromatography technology;MI:0029-cosedimentation through density gradient;MI:0040-electron microscopy	GO:0045893;GO:0005515;GO:0051090;GO:0005634	positive regulation of DNA-templated transcription;protein binding;regulation of DNA-binding transcription factor activity;nucleus	11.02.03.04.01;16.01;18.02.09;70.10	transcription activation;protein binding;regulator of transcription factor;nucleus	15175162	The CRSP-Med 2 complex is a promotor-selective coactivator. It cannot activate transcription from a VDR-responsive promoter, which needs coactivator recruitment by Med220. Several identical subunits appear in protein complexes like DRIP/ARC, CRSP, NAT, PC2, SMCC and Mediator, indicating that unique classes of transcription activators may share common sets or subsets of cofactors.	None	Two other subunits of the complex were found in the analysis, which have not been further characterized: p97 and p26.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mediator of RNA polymerase II transcription subunit 7;Mediator of RNA polymerase II transcription subunit 14;Mediator of RNA polymerase II transcription subunit 24;Mediator of RNA polymerase II transcription subunit 6;Mediator of RNA polymerase II transcription subunit 15;Mediator of RNA polymerase II transcription subunit 18;Mediator of RNA polymerase II transcription subunit 4;Mediator of RNA polymerase II transcription subunit 17;Mediator of RNA polymerase II transcription subunit 23;Mediator of RNA polymerase II transcription subunit 16	MED7;MED14;MED24;MED6;MED15;MED18;MED4;MED17;MED23;MED16	ARC34 CRSP9;ARC150 CRSP2 CXorf4 DRIP150 EXLM1 RGR1 TRAP170;ARC100 CRSP4 DRIP100 KIAA0130 THRAP4 TRAP100;ARC33;ARC105 CTG7A PCQAP TIG1 TNRC7;None;ARC36 DRIP36 VDRIP;ARC77 CRSP6 DRIP77 DRIP80 TRAP80;ARC130 CRSP3 DRIP130 KIAA1216 SUR2;DRIP92 THRAP5
912	FGFR1-KAL11 complex	Human	None	eye	P11362;P23352	2260;3730	MI:0030-cross-linking study;MI:0051-fluorescence technology	GO:0040036	regulation of fibroblast growth factor receptor signaling pathway	None	None	19696444	None	Loss-of-function mutations of anosmin-1 and FGFR1 are associated with Kallmann syndrome (KS), underlying X-linked, and autosomal dominant/recessive inheritance mode, respectively  (PMID:19696444).	Anosmin-1 directly binds to FGFR1 with high affinity. This interaction involves domains in the N terminus of anosmin-1 (cysteine-rich region, whey acidic protein-like domain and the first fibronectin type III domain) and the D2-D3 extracellular domains of FGFR1.	Homo sapiens (Human);Homo sapiens (Human)	Fibroblast growth factor receptor 1;Anosmin-1	FGFR1;ANOS1	BFGFR CEK FGFBR FLG FLT2 HBGFR;ADMLX KAL KAL1 KALIG1
915	SNARE complex (SNAP23, STX1A)	Human	None	HT29-Cl.19A colonic epithelial cells	O00161;Q16623	8773;6804	MI:0019-coimmunoprecipitation;MI:0051-fluorescence technology;MI:0096-pull down	GO:0006906;GO:0048489;GO:0016079;GO:2001225;GO:0061025;GO:0031201	vesicle fusion;synaptic vesicle transport;synaptic vesicle exocytosis;regulation of chloride transport;membrane fusion;SNARE complex	20.09.07.27;20.09.16.09.05	vesicle fusion;synaptic vesicle exocytosis	12209004	SNARE (N-ethylmaleimide-sensitive factor attachment protein receptor) complexes are responsible for membrane fusion in the secretory pathway. SNAP-23 physically associates with CFTR by binding to its amino-terminal tail, a region that modulates channel gating.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Synaptosomal-associated protein 23;Syntaxin-1A	SNAP23;STX1A	None;STX1
917	CERF complex (CECR2-containing remodeling factor complex)	Human	None	None	P28370;Q9BXF3	6594;27443	MI:0007-anti tag coimmunoprecipitation;MI:0071-molecular sieving	GO:0006265;GO:0022008;GO:0048699;GO:0051276;GO:0005634	DNA topological change;neurogenesis;generation of neurons;chromosome organization;nucleus	10.01.09.05;41.05.13;42.10.03;70.10	DNA conformation modification (e.g. chromatin);neurogenesis;organization of chromosome structure;nucleus	15640247	CERF displays an ATP hydrolyzing activity that is stimulated by nucleosomes. CERF plays a critical role in neurolation.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Probable global transcription activator SNF2L1;Chromatin remodeling regulator CECR2	SMARCA1;CECR2	SNF2L SNF2L1;KIAA1740
918	PAR3-PAR6-PALS1 complex	Human	None	None	Q8N3R9;Q8TEW0;Q9NPB6	64398;56288;50855	MI:0007-anti tag coimmunoprecipitation	GO:0051211;GO:0009798;GO:0007043;GO:0030054	anisotropic cell growth;axis specification;cell-cell junction assembly;cell junction	40.01.03;41.05.19;42.06.04;70.06	directional cell growth (morphogenesis);asymmetries and axis determination;intercellular junction (gap junction/adherens junction);cell junction	12545177	HEK 293 cells transiently expressed with Mys-PALS1 and HA-Par6 or HA-Par3 showed that Par6, but not Par3, coimmunoprecipitated with PALS1. However, when all three proteins were expressed together, the authors detected a complex of PALS1 with both Par6 and Par3.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein PALS1;Partitioning defective 3 homolog;Partitioning defective 6 homolog alpha	PALS1;PARD3;PARD6A	MPP5;PAR3 PAR3A;PAR6A
921	Remodeling and spacing factor (RSF) complex	Human	None	HeLa cells	O60264;Q96T23	8467;51773	MI:0091-chromatography technology	GO:0009117;GO:0006265;GO:0006352;GO:0051276;GO:0005634	nucleotide metabolic process;DNA topological change;DNA-templated transcription initiation;chromosome organization;nucleus	01.03;10.01.09.05;11.02.03.01.01;42.10.03;70.10	nucleotide/nucleoside/nucleobase metabolism;DNA conformation modification (e.g. chromatin);transcription initiation;organization of chromosome structure;nucleus	9836642	RSF facilitates transcription initiation by remodeling nucleosomes in the promoter region to allow the formation of preinitiation complexes.	None	None	Homo sapiens (Human);Homo sapiens (Human)	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5;Remodeling and spacing factor 1	SMARCA5;RSF1	SNF2H, WCRF135;HBXAP XAP8
923	SNF2L-RSF1 complex	Human	None	None	P28370;Q96T23	6594;51773	MI:0007-anti tag coimmunoprecipitation;MI:0071-molecular sieving	GO:0006265;GO:0051276;GO:0005634	DNA topological change;chromosome organization;nucleus	10.01.09.05;42.10.03;70.10	DNA conformation modification (e.g. chromatin);organization of chromosome structure;nucleus	15640247	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Probable global transcription activator SNF2L1;Remodeling and spacing factor 1	SMARCA1;RSF1	SNF2L SNF2L1;HBXAP XAP8
924	Toposome	Human	None	None	P07910;P11388;Q08211;Q08945;Q6P2Q9;Q96SB4;Q9NR30	3183;7153;1660;6749;10594;6732;9188	MI:0019-coimmunoprecipitation;MI:0226-ion exchange chromatography	GO:0051276;GO:0000278;GO:0051726;GO:0003677;GO:0005634	chromosome organization;mitotic cell cycle;regulation of cell cycle;DNA binding;nucleus	42.10.03;10.03.01.01;10.03.01;16.03.01;70.10	organization of chromosome structure;mitotic cell cycle;mitotic cell cycle and cell cycle control;DNA binding;nucleus	15034300	During chromosome segregation, the toposome complex separates entangled circular chromatin DNA about fourfold more efficiently than topoisomerase IIalpha alone.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Heterogeneous nuclear ribonucleoproteins C1/C2;DNA topoisomerase 2-alpha;ATP-dependent RNA helicase A;FACT complex subunit SSRP1;Pre-mRNA-processing-splicing factor 8;SRSF protein kinase 1;Nucleolar RNA helicase 2	HNRNPC;TOP2A;DHX9;SSRP1;PRPF8;SRPK1;DDX21	HNRPC;TOP2;DDX9 LKP NDH2;FACT80;PRPC8;None;None
925	SNF2H-BAZ1A complex	Human	WCRF complex; WCRF/hACF complex; BAZ1A-SMARCA5 complex	None	O60264;Q9NRL2	8467;11177	MI:0091-chromatography technology	GO:0006265;GO:0006355;GO:0051276;GO:0005634	DNA topological change;regulation of DNA-templated transcription;chromosome organization;nucleus	10.01.09.05;11.02.03.04;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcriptional control;organization of chromosome structure;nucleus	10655480	ATPase activity of WCRF complex is stimulated by nucleososmal DNA.	None	None	Homo sapiens (Human);Homo sapiens (Human)	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5;Bromodomain adjacent to zinc finger domain protein 1A	SMARCA5;BAZ1A	SNF2H, WCRF135;ACF1, WCRF180
926	SCRIB-LGL2 complex	Human	None	MDCK cells, HEK 293 cells	Q14160;Q6P1M3	23513;3993	MI:0019-coimmunoprecipitation;MI:0029-cosedimentation through density gradient;MI:0276-blue native page	GO:0051211;GO:0009798;GO:0005886;GO:0005737	anisotropic cell growth;axis specification;plasma membrane;cytoplasm	40.01.03;41.05.19;70.02;70.03	directional cell growth (morphogenesis);asymmetries and axis determination;eukaryotic plasma membrane / membrane attached;cytoplasm	16791850	Analyses done to localize the association of the proteins showed that exogenously expressed Scrib and Lgl2 can interact in either location (at the membrane and in the cytosol).	None	None	Homo sapiens (Human);Homo sapiens (Human)	Protein scribble homolog;LLGL scribble cell polarity complex component 2	SCRIB;LLGL2	CRIB1 KIAA0147 LAP4 SCRB1 VARTUL;None
927	CENP-A NAC complex	Human	CENP-A nucleosome associated complex	HeLa cells	P07199;Q03188;Q71F23;Q96BT3;Q96H22;Q9H3R5;Q9NSP4	1059;1060;79682;80152;55839;64946;79019	MI:0676-tandem affinity purification	GO:0007059;GO:0006334;GO:0000775;GO:0007093	chromosome segregation;nucleosome assembly;chromosome, centromeric region;mitotic cell cycle checkpoint signaling	10.03.04.05;70.10.04	chromosome segregation/division;centromere / kinetochore	16622419	Assembly of CENP-A NAC complex at centromeres is dependent on CENP-M, CENP-N and CENP-T.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Major centromere autoantigen B;Centromere protein C;Centromere protein U;Centromere protein T;Centromere protein N;Centromere protein H;Centromere protein M	CENPB;CENPC;CENPU;CENPT;CENPN;CENPH;CENPM	None;CENPC1 ICEN7;ICEN24 KLIP1 MLF1IP PBIP1;C16orf56, ICEN22;C16orf60 ICEN32;ICEN35;C22orf18 ICEN39 PANE1
928	SCRIB-VANGL2 complex	Human	None	epithelium	Q14160;Q9ULK5	23513;57216	MI:0007-anti tag coimmunoprecipitation;MI:0096-pull down	GO:0009798;GO:0005886	axis specification;plasma membrane	41.05.19;70.02	asymmetries and axis determination;eukaryotic plasma membrane / membrane attached	16791850	When human EGFP-hVangl2  fusion proteins expressed in transfected MDCK cells were quantitatively immunoprecipitated with anti-GFP, a small (2%) but reproducible amount of total endo Scrib was found in the full-length hVangl2 immunoprecipitate. Further analyses done in HEK293A cell extracts.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Protein scribble homolog;Vang-like protein 2	SCRIB;VANGL2	CRIB1 KIAA0147 LAP4 SCRB1 VARTUL;KIAA1215 STB1
929	CEN complex	Human	centromer chromatin complex; interphase centromere complex; ICEN complex	HeLa cells	O60264;P07199;P11021;P11142;P22087;P35226;P49450;Q02241;Q03188;Q06587;Q08945;Q13185;Q13619;Q15007;Q16531;Q53SF7;Q5T200;Q69YN4;Q6T4P5;Q71F23;Q8N0S6;Q8N1F7;Q8NEM2;Q92620;Q92674;Q96JP5;Q96T23;Q99496;Q9BS16;Q9BU64;Q9BXP5;Q9BZH6;Q9H0H5;Q9H3R5;Q9HC52;Q9NSP4;Q9Y5B9	8467;1059;3309;3312;2091;648;1058;9493;1060;6015;6749;11335;8451;9589;1642;22837;23091;25962;79948;79682;91687;9688;79801;9785;2491;80829;51773;6045;64105;79172;51593;55717;29127;64946;57332;79019;11198	MI:0006-anti bait coimmunoprecipitation;MI:0402-chromatin immunoprecipitation assay	GO:0000278;GO:0051382;GO:0051225;GO:0007098;GO:0005694	mitotic cell cycle;kinetochore assembly;spindle assembly;centrosome cycle;chromosome	10.03.01.01;10.03.04.01;10.03.05.01;70.10.03	mitotic cell cycle;centromere/kinetochore complex maturation;spindle pole body/centrosome and microtubule cycle;chromosome	15009096	None	None	Two other subunits of the complex were found in the analysis, which have not been further characterized: unknown protein (40kD) and a protein similar to Riken cDNA 2610510J17.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5;Major centromere autoantigen B;Endoplasmic reticulum chaperone BiP;Heat shock cognate 71 kDa protein;rRNA 2'-O-methyltransferase fibrillarin;Polycomb complex protein BMI-1;Histone H3-like centromeric protein A;Kinesin-like protein KIF23;Centromere protein C;E3 ubiquitin-protein ligase RING1;FACT complex subunit SSRP1;Chromobox protein homolog 3;Cullin-4A;Pre-mRNA-splicing regulator WTAP;DNA damage-binding protein 1;Cordon-bleu protein-like 1;Zinc finger CCCH domain-containing protein 13;Protein virilizer homolog;Phospholipid phosphatase-related protein type 3;Centromere protein U;Centromere protein L;Nuclear pore complex protein Nup93;SHC SH2 domain-binding protein 1;Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16;Centromere protein I;E3 ubiquitin-protein ligase ZFP91;Remodeling and spacing factor 1;E3 ubiquitin-protein ligase RING2;Centromere protein K;Centromere protein O;Serrate RNA effector molecule homolog;WD repeat-containing protein 11;Rac GTPase-activating protein 1;Centromere protein H;Chromobox protein homolog 8;Centromere protein M;FACT complex subunit SPT16	SMARCA5;CENPB;HSPA5;HSPA8;FBL;BMI1;CENPA;KIF23;CENPC;RING1;SSRP1;CBX3;CUL4A;WTAP;DDB1;COBLL1;ZC3H13;VIRMA;PLPPR3;CENPU;CENPL;NUP93;SHCBP1;DHX38;CENPI;ZFP91;RSF1;RNF2;CENPK;CENPO;SRRT;WDR11;RACGAP1;CENPH;CBX8;CENPM;SUPT16H	SNF2H, WCRF135;None;GRP78;HSC70 HSP73 HSPA10;FIB1 FLRN;PCGF4 RNF51;None;KNSL5 MKLP1;CENPC1 ICEN7;RNF1;FACT80;None;None;KIAA0105;XAP1;KIAA0977;KIAA0853;KIAA1429;LPPR3 PHP2 PRG2;ICEN24 KLIP1 MLF1IP PBIP1;C1orf155 ICEN33;KIAA0095;None;DDX38 KIAA0224 PRP16;FSHPRH1 ICEN19 LRPR1;ZNF757;HBXAP XAP8;BAP1 DING HIPI3 RING1B;ICEN37;ICEN36 MCM21R;ARS2 ASR2;BRWD2 KIAA1351 WDR15;KIAA1478 MGCRACGAP;ICEN35;PC3 RC1;C22orf18 ICEN39 PANE1;FACT140 FACTP140
930	SCRIB-GIT1-ARHGEF7 complex	Human	None	nontransformed mammary epithelial MCF10-2A cells	Q14155;Q14160;Q9Y2X7	8874;23513;28964	MI:0006-anti bait coimmunoprecipitation;MI:0069-mass spectrometry studies of complexes;MI:0096-pull down	GO:0006887;GO:0005886;GO:0007268;GO:0045197	exocytosis;plasma membrane;chemical synaptic transmission;establishment or maintenance of epithelial cell apical/basal polarity	20.09.16.09.03;70.02;34.03.01	exocytosis;eukaryotic plasma membrane / membrane attached;synaptic transmission	15182672	Yeast two-hybrid analysis showed that beta-PIX directly interacts with hScrib and hScrib PDZ domains. GIT1 had no affinity for Scrib but, as expected, directly bound to beta-PIX. The data highlight the important role of hScrib in the retention of beta-PIX at the plasma membrane upon membrane depolarization.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Rho guanine nucleotide exchange factor 7;Protein scribble homolog;ARF GTPase-activating protein GIT1	ARHGEF7;SCRIB;GIT1	COOL1 KIAA0142 P85SPR PAK3BP PIXB;CRIB1 KIAA0147 LAP4 SCRB1 VARTUL;None
933	SCRIB-APC complex	Human	None	None	P25054;Q14160	324;23513	MI:0006-anti bait coimmunoprecipitation;MI:0096-pull down	GO:0051211;GO:0009798;GO:0007043;GO:0030182;GO:0030855;GO:0002009;GO:0007416	anisotropic cell growth;axis specification;cell-cell junction assembly;neuron differentiation;epithelial cell differentiation;morphogenesis of an epithelium;synapse assembly	40.01.03;41.05.19;42.06.04;43.03.13;45.03.09;41.05.13.01	directional cell growth (morphogenesis);asymmetries and axis determination;intercellular junction (gap junction/adherens junction);neuron;epithelium;synaptogenesis	16611247	The in vitro translated APC bound to the PDZ domains 1 and 4 of hScrib. Mutational analysis provided the evidence that APC interacts with hScrib through its C terminal class 1 PDZ domain-binding sequence Threonine-X-Valine, which is shared by the C terminal sequences of the high-risk HPV E6 proteins.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Adenomatous polyposis coli protein;Protein scribble homolog	APC;SCRIB	DP2.5;CRIB1 KIAA0147 LAP4 SCRB1 VARTUL
934	FACT-NEK9 complex	Human	None	None	Q08945;Q8TD19;Q9Y5B9	6749;91754;11198	MI:0006-anti bait coimmunoprecipitation	GO:0006265;GO:0000082;GO:0006354;GO:0006468;GO:0051276;GO:0005634	DNA topological change;G1/S transition of mitotic cell cycle;DNA-templated transcription elongation;protein phosphorylation;chromosome organization;nucleus	10.01.09.05;10.03.01.01.03;11.02.03.01.04;14.07.03;42.10.03;70.10	DNA conformation modification (e.g. chromatin);G1/S transition of mitotic cell cycle;transcription elongation;modification by phosphorylation, dephosphorylation, autophosphorylation;organization of chromosome structure;nucleus	14660563	Nek9 forms a stable, approximately 600-kDa complex with FACT in the interphase nuclei.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	FACT complex subunit SSRP1;Serine/threonine-protein kinase Nek9;FACT complex subunit SPT16	SSRP1;NEK9;SUPT16H	FACT80;KIAA1995 NEK8 NERCC;FACT140 FACTP140
936	FACT complex	Human	None	None	Q08945;Q9Y5B9	6749;11198	MI:0006-anti bait coimmunoprecipitation	GO:0006265;GO:0006354;GO:0051276;GO:0005634	DNA topological change;DNA-templated transcription elongation;chromosome organization;nucleus	10.01.09.05;11.02.03.01.04;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription elongation;organization of chromosome structure;nucleus	10421373	FACT (for facilitates chromatin transcription) is a chromatin-specific elongation factor required for transcription of chromatin templates in vitro.	None	None	Homo sapiens (Human);Homo sapiens (Human)	FACT complex subunit SSRP1;FACT complex subunit SPT16	SSRP1;SUPT16H	FACT80;FACT140 FACTP140
938	FACT complex, UV-activated	Human	p53 Ser-392 kinase complex	None	P19784;P67870;P68400;Q08945;Q9Y5B9	1459;1460;1457;6749;11198	MI:0071-molecular sieving	GO:0006468;GO:0006974;GO:0009314;GO:0005634	protein phosphorylation;cellular response to DNA damage stimulus;response to radiation;nucleus	14.07.03;32.01.09;32.01.13;70.10	modification by phosphorylation, dephosphorylation, autophosphorylation;DNA damage response;electromagnetic waves stress response (e.g. UV, X-ray);nucleus	11239457	In vitro studies show that FACT alters the specificity of CK2 in the complex such that it selectively phosphorylates p53. Phosphorylation by the kinase complex enhances p53 activity.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Casein kinase II subunit alpha';Casein kinase II subunit beta;Casein kinase II subunit alpha;FACT complex subunit SSRP1;FACT complex subunit SPT16	CSNK2A2;CSNK2B;CSNK2A1;SSRP1;SUPT16H	CK2A2;CK2N G5A;CK2A1;FACT80;FACT140 FACTP140
943	Class C VPS complex (STX7, VPS11, VPS18)	Human	None	HeLa cells; HEK 293 cells	O15400;Q9H270;Q9P253	8417;55823;57617	MI:0019-coimmunoprecipitation;MI:0047-far western blotting;MI:0071-molecular sieving;MI:0416-fluorescence microscopy	GO:0016192;GO:0005768;GO:0005773;GO:0005764;GO:0005770	vesicle-mediated transport;endosome;vacuole;lysosome;late endosome	20.09.07;70.22;70.25	vesicular transport (Golgi network, etc.);endosome;vacuole or lysosome	11382755	Mammalian Class C Vps proteins are predominantly associated with late endosomes/lysosomes and mediate vesicle trafficking steps in the endosome/lysosome pathway. They exist as a hetero-oligomeric complex primarily associated with late endosomes/lysosomes and that the complex interacts with syntaxin-7, suggesting that it has a role in SNARE complex assembly.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Syntaxin-7;Vacuolar protein sorting-associated protein 11 homolog;Vacuolar protein sorting-associated protein 18 homolog	STX7;VPS11;VPS18	None;RNF108;KIAA1475
944	Class C VPS complex (VPS11, VPS16, VPS18)	Human	None	HeLa cells; HEK 293 cells	Q9H269;Q9H270;Q9P253	64601;55823;57617	MI:0019-coimmunoprecipitation;MI:0047-far western blotting;MI:0071-molecular sieving;MI:0416-fluorescence microscopy	GO:0016192;GO:0005768;GO:0005773;GO:0005764	vesicle-mediated transport;endosome;vacuole;lysosome	20.09.07;70.22;70.25	vesicular transport (Golgi network, etc.);endosome;vacuole or lysosome	11382755	Mammalian Class C Vps proteins are predominantly associated with late endosomes/lysosomes, mediate vesicle trafficking steps in the endosome/lysosome pathway and are suggested to play a role in SNARE complex assembly.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Vacuolar protein sorting-associated protein 16 homolog;Vacuolar protein sorting-associated protein 11 homolog;Vacuolar protein sorting-associated protein 18 homolog	VPS16;VPS11;VPS18	None;RNF108;KIAA1475
947	CDC7-DBF7 complex	Human	None	None	O00311;Q9UBU7	8317;10926	MI:0019-coimmunoprecipitation	GO:0006260;GO:0051052	DNA replication;regulation of DNA metabolic process	10.01.03;10.01.11	DNA synthesis and replication;regulation of DNA processing	10523313	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cell division cycle 7-related protein kinase;Protein DBF4 homolog A	CDC7;DBF4	CDC7L1;ASK DBF4A ZDBF1
955	LLGL2-PAR-6B-PRKCI complex	Human	None	epithelium	P41743;Q6P1M3;Q9BYG5	5584;3993;84612	MI:0007-anti tag coimmunoprecipitation	GO:0051211;GO:0009798;GO:0007043;GO:0030054	anisotropic cell growth;axis specification;cell-cell junction assembly;cell junction	40.01.03;41.05.19;42.06.04;70.06	directional cell growth (morphogenesis);asymmetries and axis determination;intercellular junction (gap junction/adherens junction);cell junction	12725730	Mammalian Lgl-2 competes with PAR-3 for its incorporation to the PAR-6B/aPKC lambda complex in cDNA-transfected 293T cells  and support the presence of two independent protein complexes containing PAR-6B/aPKC lambda. Further results indicate that mLgl-2 interacts with the PDZ domain of PAR-6B and with the kinase domain of aPKC lambda and forms a protein complex independently of the one containing PAR-3. It was suggested that phosphorylation of mLgl-1/2 by aPKC lambda occurs during the cell-cell contact-induced cell polarization and that this is accompanied by dissociation of the interaction between mLgl-2 and the PAR-6B/aPKC lambda complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein kinase C iota type;LLGL scribble cell polarity complex component 2;Partitioning defective 6 homolog beta	PRKCI;LLGL2;PARD6B	DXS1179E;None;PAR6B
956	PAR-3-PAR-6B-PRKCI complex	Human	None	epithelium	P41743;Q8TEW0;Q9BYG5	5584;56288;84612	MI:0007-anti tag coimmunoprecipitation	GO:0051211;GO:0009798;GO:0007043;GO:0030054	anisotropic cell growth;axis specification;cell-cell junction assembly;cell junction	40.01.03;41.05.19;42.06.04;70.06	directional cell growth (morphogenesis);asymmetries and axis determination;intercellular junction (gap junction/adherens junction);cell junction	12725730	Mammalian Lgl-2 competes with PAR-3 for its incorporation to the PAR-6B/aPKC lambda complex in cDNA-transfected 293T cells  and support the presence of two independent protein complexes containing PAR-6B/aPKC lambda.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein kinase C iota type;Partitioning defective 3 homolog;Partitioning defective 6 homolog beta	PRKCI;PARD3;PARD6B	DXS1179E;PAR3 PAR3A;PAR6B
959	LLGL1-PAR-6B-PRKCI complex	Human	None	epithelium	P41743;Q15334;Q9BYG5	5584;3996;84612	MI:0019-coimmunoprecipitation	GO:0051211;GO:0009798;GO:0007043;GO:0030054	anisotropic cell growth;axis specification;cell-cell junction assembly;cell junction	40.01.03;41.05.19;42.06.04;70.06	directional cell growth (morphogenesis);asymmetries and axis determination;intercellular junction (gap junction/adherens junction);cell junction	12725730	Experiments done in lysates of MDCK, MTD-1A, or Caco 2 cells. The results indicate that PAR-6/aPKC selectively interacts with either mLgl or PAR-3 under the control of aPKC activity to regulate epithelial cell polarity.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein kinase C iota type;Lethal(2) giant larvae protein homolog 1;Partitioning defective 6 homolog beta	PRKCI;LLGL1;PARD6B	DXS1179E;DLG4 HUGL HUGL1;PAR6B
964	BRCA1-RAD50-MRE11-NBS1 complex	Human	BRCA1-RAD50-MRE11-p95 complex	T24 cells	O60934;P38398;P49959;Q92878	4683;672;4361;10111	MI:0006-anti bait coimmunoprecipitation;MI:0416-fluorescence microscopy	GO:0006281;GO:0006974;GO:0005634	DNA repair;cellular response to DNA damage stimulus;nucleus	10.01.05.01;32.01.09;70.10	DNA repair;DNA damage response;nucleus	10426999	None	Formation of this complex was dramatically reduced in HCC/1937 breast cancer cells carrying a homozygous mutation in BRCA1 but was restored by transfection of wild-type BRCA1.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Nibrin;Breast cancer type 1 susceptibility protein;Double-strand break repair protein MRE11;DNA repair protein RAD50	NBN;BRCA1;MRE11;RAD50	NBS NBS1 P95;RNF53;HNGS1 MRE11A;None
974	EED-EZH2 complex	Human	ESC-E(Z) complex; H3-specific methyltransferase complex	None	O75530;Q09028;Q15022;Q15910;Q6ZN18	8726;5928;23512;2146;121536	MI:0006-anti bait coimmunoprecipitation;MI:0071-molecular sieving;MI:0091-chromatography technology	GO:0006265;GO:0032774;GO:0006479;GO:0051276;GO:0005634	DNA topological change;RNA biosynthetic process;protein methylation;chromosome organization;nucleus	10.01.09.05;11.02;14.07.09;42.10.03;70.10	DNA conformation modification (e.g. chromatin);RNA synthesis;posttranslational modification of amino acids (e.g. hydroxylation, methylation);organization of chromosome structure;nucleus	12351676	The results support a model in which ESC-E(Z)-mediated H3-K27 methylation serves as a signal for the recruitment of the PRC1 complex by facilitating PC binding.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Polycomb protein EED;Histone-binding protein RBBP4;Polycomb protein SUZ12;Histone-lysine N-methyltransferase EZH2;Zinc finger protein AEBP2	EED;RBBP4;SUZ12;EZH2;AEBP2	None;RBAP48;CHET9 JJAZ1 KIAA0160;KMT6;None
994	GAA1-GPI8-PIGT-PIG-PIGS complex	Human	None	None	O43292;Q92643;Q969N2;Q96S52;Q9H490	8733;10026;51604;94005;128869	MI:0019-coimmunoprecipitation	GO:0006644;GO:0008654;GO:0009395;GO:0005886	phospholipid metabolic process;phospholipid biosynthetic process;phospholipid catabolic process;plasma membrane	01.06.02.01;70.02	phospholipid metabolism;eukaryotic plasma membrane / membrane attached	14660601	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Glycosylphosphatidylinositol anchor attachment 1 protein;GPI-anchor transamidase;GPI transamidase component PIG-T;GPI transamidase component PIG-S;Phosphatidylinositol glycan anchor biosynthesis class U protein	GPAA1;PIGK;PIGT;PIGS;PIGU	GAA1;GPI8;None;None;CDC91L1
996	Polycomb repressive complex 2/3	Human	PRC2/3 complex	HeLa cells	O75530;Q09028;Q15022;Q15910;Q16576	8726;5928;23512;2146;5931	MI:0091-chromatography technology	GO:0005634;GO:0016571;GO:0045892;GO:0070734	nucleus;histone methylation;negative regulation of DNA-templated transcription;histone H3-K27 methylation	70.10;11.02.03.04.03	nucleus;transcription repression	15099518	The PRC2 complex associates with all three EED isoforms, with the largest form of EED in highest abundance. The PRC3 complex associates with the two shorter isoforms of EED (Eed2/3). PRC3 complex preferentially methylates nucleosomal H3-lysine 27, whereas the PRC2 complex preferentially methylates nucleosomal H1-lysine 26.	None	Since the isoforms described in the paper do not correspond to the sequences of the isoforms shown in UniProt we only describe one complex with the canonical sequence.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Polycomb protein EED;Histone-binding protein RBBP4;Polycomb protein SUZ12;Histone-lysine N-methyltransferase EZH2;Histone-binding protein RBBP7	EED;RBBP4;SUZ12;EZH2;RBBP7	None;RBAP48;CHET9 JJAZ1 KIAA0160;KMT6;RBAP46
997	KIN17-PCNA-RPA70 complex	Human	None	None	O60870;P12004;P27694	22944;5111;6117	MI:0040-electron microscopy;MI:0091-chromatography technology	GO:0006260;GO:0000075;GO:0003677;GO:0016363	DNA replication;cell cycle checkpoint signaling;DNA binding;nuclear matrix	10.01.03;10.03.01.03;16.03.01;70.10.06	DNA synthesis and replication;cell cycle checkpoints (checkpoints of morphogenesis, DNA-damage,-replication, mitotic phase and spindle);DNA binding;nuclear matrix	15831485	This complex associates with DNA polymerase alpha.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA/RNA-binding protein KIN17;Proliferating cell nuclear antigen;Replication protein A 70 kDa DNA-binding subunit	KIN;PCNA;RPA1	BTCD KIN17;None;REPA1 RPA70
999	p23 protein complex	Human	None	None	O75340;P22626;Q15185	10016;3181;10728	MI:0019-coimmunoprecipitation;MI:0069-mass spectrometry studies of complexes	GO:0005515;GO:0043067	protein binding;regulation of programmed cell death	16.01;40.10.02.04	protein binding;regulation of apoptosis	14675759	None	The expression of p23 is increased  after rat focal cerebral ischemia.DHNRPA2B1 is clinical marker of early lung cancer detection (PMID:10632338).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Programmed cell death protein 6;Heterogeneous nuclear ribonucleoproteins A2/B1;Prostaglandin E synthase 3	PDCD6;HNRNPA2B1;PTGES3	ALG2;HNRPA2B1;P23 TEBP
1000	TorsinA-TorsinB complex	Human	None	brain	O14656;O14657	1861;27348	MI:0019-coimmunoprecipitation	GO:0008015	blood circulation	34.11.13.07	circulation (e.g. blood pressure)	15147511	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Torsin-1A;Torsin-1B	TOR1A;TOR1B	DQ2 DYT1 TA TORA;DQ1
1003	RC complex (Replication competent complex)	Human	None	HeLa cells	P09884;P20248;P24941;P35249;P35250;P35251;P40937;P40938;Q14181	5422;890;1017;5984;5982;5981;5985;5983;23649	MI:0029-cosedimentation through density gradient;MI:0071-molecular sieving	GO:0006260;GO:0000075;GO:0003677;GO:0005694;GO:0005634	DNA replication;cell cycle checkpoint signaling;DNA binding;chromosome;nucleus	10.01.03;10.03.01.03;16.03.01;70.10.03;70.10	DNA synthesis and replication;cell cycle checkpoints (checkpoints of morphogenesis, DNA-damage,-replication, mitotic phase and spindle);DNA binding;chromosome;nucleus	12006500	RC complex might be regulated by specific cyclin/Cdk complexes (PMID:12006500).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA polymerase alpha catalytic subunit;Cyclin-A2;Cyclin-dependent kinase 2;Replication factor C subunit 4;Replication factor C subunit 2;Replication factor C subunit 1;Replication factor C subunit 5;Replication factor C subunit 3;DNA polymerase alpha subunit B	POLA1;CCNA2;CDK2;RFC4;RFC2;RFC1;RFC5;RFC3;POLA2	POLA;CCN1 CCNA;CDKN2;None;None;RFC140;None;None;None
1004	RC complex, S-phase-specific	Human	RC complex during S-phase of cell cycle	HeLa cells	P09874;P09884;P11387;P15927;P18858;P20248;P24941;P27694;P28340;P35244;P35250;P35251;Q07864	142;5422;7150;6118;3978;890;1017;6117;5424;6119;5982;5981;5426	MI:0006-anti bait coimmunoprecipitation;MI:0029-cosedimentation through density gradient;MI:0071-molecular sieving	GO:0005694;GO:0000075;GO:0003677;GO:0006260;GO:0005634	chromosome;cell cycle checkpoint signaling;DNA binding;DNA replication;nucleus	70.10.03;10.03.01.03;16.03.01;10.01.03;70.10	chromosome;cell cycle checkpoints (checkpoints of morphogenesis, DNA-damage,-replication, mitotic phase and spindle);DNA binding;DNA synthesis and replication;nucleus	12006500	CDK2 associates with the RC complex only during the S-phase of the cell cycle, but disappeares in the G2-phase.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Poly [ADP-ribose] polymerase 1;DNA polymerase alpha catalytic subunit;DNA topoisomerase 1;Replication protein A 32 kDa subunit;DNA ligase 1;Cyclin-A2;Cyclin-dependent kinase 2;Replication protein A 70 kDa DNA-binding subunit;DNA polymerase delta catalytic subunit;Replication protein A 14 kDa subunit;Replication factor C subunit 2;Replication factor C subunit 1;DNA polymerase epsilon catalytic subunit A	PARP1;POLA1;TOP1;RPA2;LIG1;CCNA2;CDK2;RPA1;POLD1;RPA3;RFC2;RFC1;POLE	ADPRT PPOL;POLA;None;REPA2 RPA32 RPA34;None;CCN1 CCNA;CDKN2;REPA1 RPA70;POLD;REPA3 RPA14;None;RFC140;POLE1
1005	RC complex during G2/M-phase of cell cycle	Human	None	HeLa cells	P06493;P09874;P09884;P11387;P14635;P15927;P20248;P27694;P28340;P35244;P35250;P35251;Q07864	983;142;5422;7150;891;6118;890;6117;5424;6119;5982;5981;5426	MI:0006-anti bait coimmunoprecipitation;MI:0029-cosedimentation through density gradient;MI:0071-molecular sieving	GO:0006260;GO:0000075;GO:0003677;GO:0005694;GO:0005634	DNA replication;cell cycle checkpoint signaling;DNA binding;chromosome;nucleus	10.01.03;10.03.01.03;16.03.01;70.10.03;70.10	DNA synthesis and replication;cell cycle checkpoints (checkpoints of morphogenesis, DNA-damage,-replication, mitotic phase and spindle);DNA binding;chromosome;nucleus	12006500	CDK1 and cyclin B1 associate with RC complex only during G2/M-phase of cell cycle. DNA ligase I is not found in the RC complex during G2/M-phase.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cyclin-dependent kinase 1;Poly [ADP-ribose] polymerase 1;DNA polymerase alpha catalytic subunit;DNA topoisomerase 1;G2/mitotic-specific cyclin-B1;Replication protein A 32 kDa subunit;Cyclin-A2;Replication protein A 70 kDa DNA-binding subunit;DNA polymerase delta catalytic subunit;Replication protein A 14 kDa subunit;Replication factor C subunit 2;Replication factor C subunit 1;DNA polymerase epsilon catalytic subunit A	CDK1;PARP1;POLA1;TOP1;CCNB1;RPA2;CCNA2;RPA1;POLD1;RPA3;RFC2;RFC1;POLE	CDC2 CDC28A CDKN1 P34CDC2;ADPRT PPOL;POLA;None;CCNB;REPA2 RPA32 RPA34;CCN1 CCNA;REPA1 RPA70;POLD;REPA3 RPA14;None;RFC140;POLE1
1007	CAK core complex (Cdk-activating kinase core complex)	Human	None	None	P50613;P51946	1022;902	MI:0004-affinity chromatography technology	GO:0007049;GO:0009299;GO:0051090;GO:0005634;GO:0070816;GO:0036211	cell cycle;mRNA transcription;regulation of DNA-binding transcription factor activity;nucleus;phosphorylation of RNA polymerase II C-terminal domain;protein modification process	10.03;11.02.03;18.02.09;70.10	cell cycle;mRNA synthesis;regulator of transcription factor;nucleus	7533895	CAK complex phosphorylates the carboxy-terminal domain of the largest subunit of RNA polymerase II.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cyclin-dependent kinase 7;Cyclin-H	CDK7;CCNH	CAK CAK1 CDKN7 MO15 STK1;None
1010	CAK complex (Cdk-activating kinase complex)	Human	CCNH-CDK7-MNAT1 complex	HeLa cells	P50613;P51946;P51948	1022;902;4331	MI:0071-molecular sieving;MI:0091-chromatography technology	GO:0007049;GO:0019209;GO:0051090;GO:0005634;GO:0070816	cell cycle;kinase activator activity;regulation of DNA-binding transcription factor activity;nucleus;phosphorylation of RNA polymerase II C-terminal domain	10.03;18.02.01.01.05;18.02.09;70.10	cell cycle;kinase activator;regulator of transcription factor;nucleus	8692842	MAT1 is required for stabilization and assembly of the active CAK complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cyclin-dependent kinase 7;Cyclin-H;CDK-activating kinase assembly factor MAT1	CDK7;CCNH;MNAT1	CAK CAK1 CDKN7 MO15 STK1;None;CAP35 MAT1 RNF66
1028	HNF4A-SUB1 complex	Human	None	None	P41235;P53999	3172;10923	MI:0024-confirmational text mining	GO:0045893	positive regulation of DNA-templated transcription	11.02.03.04.01	transcription activation	17317687	The hepatocellular inflammatory-redox (IR) state enhances PC4-HNF4 binding to upregulate transcription of target hepatocyte genes, such as iNOS.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Hepatocyte nuclear factor 4-alpha;Activated RNA polymerase II transcriptional coactivator p15	HNF4A;SUB1	HNF4 NR2A1 TCF14;PC4 RPO2TC1
1029	TFIIH transcription factor complex	Human	None	HeLa cells	P18074;P19447;P32780;P50613;P51946;P51948;Q13888;Q13889;Q6ZYL4;Q92759	2068;2071;2965;1022;902;4331;2966;2967;404672;2968	MI:0071-molecular sieving;MI:0091-chromatography technology	GO:0006281;GO:0007049;GO:0006355;GO:0005634	DNA repair;cell cycle;regulation of DNA-templated transcription;nucleus	10.01.05.01;10.03;11.02.03.04;70.10	DNA repair;cell cycle;transcriptional control;nucleus	8692842	Transcription factor IIH (TFIIH) is a multisubunit complex required for transcription and for DNA nucleotide excision repair.The GTF2H5 gene product has a role in regulating the level of TFIIH.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	General transcription and DNA repair factor IIH helicase subunit XPD;General transcription and DNA repair factor IIH helicase subunit XPB;General transcription factor IIH subunit 1;Cyclin-dependent kinase 7;Cyclin-H;CDK-activating kinase assembly factor MAT1;General transcription factor IIH subunit 2;General transcription factor IIH subunit 3;General transcription factor IIH subunit 5;General transcription factor IIH subunit 4	ERCC2;ERCC3;GTF2H1;CDK7;CCNH;MNAT1;GTF2H2;GTF2H3;GTF2H5;GTF2H4	XPD XPDC;XPB XPBC;BTF2;CAK CAK1 CDKN7 MO15 STK1;None;CAP35 MAT1 RNF66;BTF2P44;None;C6orf175 TTDA;None
1030	CAK-ERCC2 complex	Human	None	HeLa cells	P18074;P50613;P51946;P51948	2068;1022;902;4331	MI:0006-anti bait coimmunoprecipitation;MI:0071-molecular sieving;MI:0091-chromatography technology	GO:0005634;GO:0007049;GO:0051090	nucleus;cell cycle;regulation of DNA-binding transcription factor activity	70.10;10.03;18.02.09	nucleus;cell cycle;regulator of transcription factor	8692842	CAK-ERCC2 can efficiently associate with core-TFIIH to reconstitute holo-TFIIH transcription activity.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	General transcription and DNA repair factor IIH helicase subunit XPD;Cyclin-dependent kinase 7;Cyclin-H;CDK-activating kinase assembly factor MAT1	ERCC2;CDK7;CCNH;MNAT1	XPD XPDC;CAK CAK1 CDKN7 MO15 STK1;None;CAP35 MAT1 RNF66
1031	ORC complex (origin recognition complex)	Human	None	HeLa cells	O43913;O43929;Q13415;Q13416;Q9UBD5;Q9Y5N6	5001;5000;4998;4999;23595;23594	MI:0006-anti bait coimmunoprecipitation	GO:0006267;GO:0003688;GO:0005524;GO:0005694	pre-replicative complex assembly involved in nuclear cell cycle DNA replication;DNA replication origin binding;ATP binding;chromosome	10.01.03.03;16.19.03;70.10.03	ori recognition and priming complex formation;ATP binding;chromosome	11323433	HsOrc2, HsOrc3, and HsOrc4 form a core upon which the ordered assembly of HsOrc5 and HsOrc1 takes place. HsOrc6 appears to be the most weakly bound subunit in the complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Origin recognition complex subunit 5;Origin recognition complex subunit 4;Origin recognition complex subunit 1;Origin recognition complex subunit 2;Origin recognition complex subunit 3;Origin recognition complex subunit 6	ORC5;ORC4;ORC1;ORC2;ORC3;ORC6	ORC5L;ORC4L;ORC1L PARC1;ORC2L;LATHEO ORC3L;ORC6L
1032	ORC 2-4 complex (origin recognition 2-4 complex)	Human	None	HeLa cells	O43929;Q13416;Q9UBD5	5000;4999;23595	MI:0006-anti bait coimmunoprecipitation	GO:0006267;GO:0003688;GO:0005524;GO:0005694	pre-replicative complex assembly involved in nuclear cell cycle DNA replication;DNA replication origin binding;ATP binding;chromosome	10.01.03.03;16.19.03;70.10.03	ori recognition and priming complex formation;ATP binding;chromosome	11323433	HsOrc2, HsOrc3, and HsOrc4 form a core upon which the ordered assembly of HsOrc5 and HsOrc1 takes place.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Origin recognition complex subunit 4;Origin recognition complex subunit 2;Origin recognition complex subunit 3	ORC4;ORC2;ORC3	ORC4L;ORC2L;LATHEO ORC3L
1034	ORC 2-5 complex (origin recognition 2-5 complex)	Human	None	None	O43913;O43929;Q13416;Q9UBD5	5001;5000;4999;23595	MI:0006-anti bait coimmunoprecipitation	GO:0006267;GO:0003688;GO:0005524;GO:0005694	pre-replicative complex assembly involved in nuclear cell cycle DNA replication;DNA replication origin binding;ATP binding;chromosome	10.01.03.03;16.19.03;70.10.03	ori recognition and priming complex formation;ATP binding;chromosome	10945994	Only a small fraction of human ORC1 and ORC6 is likely to be associated with a subcomplex of ORC2, 3, 4, and 5.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Origin recognition complex subunit 5;Origin recognition complex subunit 4;Origin recognition complex subunit 2;Origin recognition complex subunit 3	ORC5;ORC4;ORC2;ORC3	ORC5L;ORC4L;ORC2L;LATHEO ORC3L
1037	TFIIH transcription factor core complex	Human	None	None	P19447;P32780;Q13888;Q13889;Q92759	2071;2965;2966;2967;2968	MI:0006-anti bait coimmunoprecipitation	GO:0006281;GO:0007049;GO:0006355;GO:0005634	DNA repair;cell cycle;regulation of DNA-templated transcription;nucleus	10.01.05.01;10.03;11.02.03.04;70.10	DNA repair;cell cycle;transcriptional control;nucleus	9118947	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	General transcription and DNA repair factor IIH helicase subunit XPB;General transcription factor IIH subunit 1;General transcription factor IIH subunit 2;General transcription factor IIH subunit 3;General transcription factor IIH subunit 4	ERCC3;GTF2H1;GTF2H2;GTF2H3;GTF2H4	XPB XPBC;BTF2;BTF2P44;None;None
1038	ORC 1-5 complex (origin recognition 1-5 complex)	Human	None	None	O43913;O43929;Q13415;Q13416;Q9UBD5	5001;5000;4998;4999;23595	MI:0029-cosedimentation through density gradient;MI:0071-molecular sieving	GO:0006267;GO:0003688;GO:0005524;GO:0005694	pre-replicative complex assembly involved in nuclear cell cycle DNA replication;DNA replication origin binding;ATP binding;chromosome	10.01.03.03;16.19.03;70.10.03	ori recognition and priming complex formation;ATP binding;chromosome	15618391	ATP-binding motifs of Orc1, Orc4, Orc5 are all essential for the replication activity of the ORC complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Origin recognition complex subunit 5;Origin recognition complex subunit 4;Origin recognition complex subunit 1;Origin recognition complex subunit 2;Origin recognition complex subunit 3	ORC5;ORC4;ORC1;ORC2;ORC3	ORC5L;ORC4L;ORC1L PARC1;ORC2L;LATHEO ORC3L
1039	PCNA-PAF complex	Human	None	None	P12004;Q15004	5111;9768	MI:0019-coimmunoprecipitation	GO:0006281;GO:0007049;GO:0006915;GO:0005634;GO:0005739	DNA repair;cell cycle;apoptotic process;nucleus;mitochondrion	10.01.05.01;10.03;40.10.02;70.10;70.16	DNA repair;cell cycle;apoptosis (type I programmed cell death);nucleus;mitochondrion	16288740	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Proliferating cell nuclear antigen;PCNA-associated factor	PCNA;PCLAF	None;KIAA0101 NS5ATP9 PAF
1040	p33ING1b-PCNA complex	Human	None	None	Q15004;Q9UK53	9768;3621	MI:0019-coimmunoprecipitation	GO:0006281;GO:0007049;GO:0006915;GO:0005634;GO:0005739	DNA repair;cell cycle;apoptotic process;nucleus;mitochondrion	10.01.05.01;10.03;40.10.02;70.10;70.16	DNA repair;cell cycle;apoptosis (type I programmed cell death);nucleus;mitochondrion	16288740	p15(PAF) forms part of a larger protein complex potentially involved in the regulation of DNA repair, apoptosis and cell cycle progression.	None	None	Homo sapiens (Human);Homo sapiens (Human)	PCNA-associated factor;Inhibitor of growth protein 1	PCLAF;ING1	KIAA0101 NS5ATP9 PAF;None
1041	Alpha-dystrobrevin-ZO-1-actin complex	Human	None	MDCK cells, HT29 cells, epithelium	P60709;Q07157;Q9Y4J8	60;7082;1837	MI:0006-anti bait coimmunoprecipitation	GO:0007043;GO:0030054	cell-cell junction assembly;cell junction	42.06.04;70.06	intercellular junction (gap junction/adherens junction);cell junction	15834686	The TJ- protein ZO-1 and actin were demonstrated in immunoprecipitates of alpha-DB from MDCK I and HT 29 cell lines. These findings suggest that alpha-DB is specifically associated with the reorganizing TJ.	None	Since the authors did not actin, we used isoform ACTB.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Actin, cytoplasmic 1;Tight junction protein ZO-1;Dystrobrevin alpha	ACTB;TJP1;DTNA	None;ZO1;DRP3
1042	SRA-SRC-1 ribonucleoprotein complex	Human	None	None	Q15788;Q9HD15	8648;10011	MI:0019-coimmunoprecipitation;MI:0071-molecular sieving	GO:0045893;GO:0023052;GO:0005634	positive regulation of DNA-templated transcription;signaling;nucleus	11.02.03.04.01;30.01;70.10	transcription activation;cellular signalling;nucleus	10199399	The authors conclude that SRA exists in a ribonucleoprotein complex containing SRC-1 and that this complex is recruited by a steroid receptor.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Nuclear receptor coactivator 1;Steroid receptor RNA activator 1	NCOA1;SRA1	BHLHE74 SRC1;None
1045	RAN-SNUPN-XPO1 complex	Human	Snurportin-CRM1-RanGTP complex	HeLa cells	O14980;O95149;P62826	7514;10073;5901	MI:0096-pull down	GO:0005737;GO:0005634;GO:0006611	cytoplasm;nucleus;protein export from nucleus	70.03;70.10	cytoplasm;nucleus	10209022	The complex is exported from the nucleus to the cytoplasm where  RanGTP is removed from CRM1 through the action of RanBP1 and RanGAP.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Exportin-1;Snurportin-1;GTP-binding nuclear protein Ran	XPO1;SNUPN;RAN	CRM1;RNUT1 SPN1;ARA24
1051	Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, RBX1)	Human	None	HeLa cell extracts	P62877;P63208;Q13309;Q13616	9978;6500;6502;8454	MI:0029-cosedimentation through density gradient;MI:0069-mass spectrometry studies of complexes	GO:0016567;GO:0043161;GO:0006511;GO:0005737	protein ubiquitination;proteasome-mediated ubiquitin-dependent protein catabolic process;ubiquitin-dependent protein catabolic process;cytoplasm	14.07.05;14.13.01.01;70.03	modification by ubiquitination, deubiquitination;proteasomal degradation (ubiquitin/proteasomal pathway);cytoplasm	10230406	Ubiquitin E3 ligases covalently attach ubiquitin to a lysine residue on a target protein. Polyubiquitination marks proteins for degradation by the proteasome. Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase RBX1;S-phase kinase-associated protein 1;S-phase kinase-associated protein 2;Cullin-1	RBX1;SKP1;SKP2;CUL1	RNF75 ROC1;EMC19 OCP2 SKP1A TCEB1L;FBXL1;None
1052	Ubiquitin E3 ligase (FBXW11, SKP1A, CUL1, RBX1)	Human	SCF(HOS)-ROC1  complex	None	P62877;P63208;Q13616;Q9UKB1	9978;6500;8454;23291	MI:0004-affinity chromatography technology	GO:0016567;GO:0043161;GO:0006511	protein ubiquitination;proteasome-mediated ubiquitin-dependent protein catabolic process;ubiquitin-dependent protein catabolic process	14.07.05;14.13.01.01	modification by ubiquitination, deubiquitination;proteasomal degradation (ubiquitin/proteasomal pathway)	10230406	Ubiquitin E3 ligases covalently attach ubiquitin to a lysine residue on a target protein. Polyubiquitination marks proteins for degradation by the proteasome. This complex catalyzes the phosphorylation-dependent ubiquitination of NF-kappa-B inhibitor alpha.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase RBX1;S-phase kinase-associated protein 1;Cullin-1;F-box/WD repeat-containing protein 11	RBX1;SKP1;CUL1;FBXW11	RNF75 ROC1;EMC19 OCP2 SKP1A TCEB1L;None;BTRCP2 FBW1B FBXW1B KIAA0696
1054	ESR1-RELA-BCL3-NCOA3 complex	Human	None	None	P03372;P20749;Q04206;Q9Y6Q9	2099;602;5970;8202	MI:0019-coimmunoprecipitation	GO:2001141;GO:0006355;GO:0023052	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;signaling	11.02.03.04;30.01	transcriptional control;cellular signalling	16331275	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Estrogen receptor;B-cell lymphoma 3 protein;Transcription factor p65;Nuclear receptor coactivator 3	ESR1;BCL3;RELA;NCOA3	ESR NR3A1;BCL4 D19S37;NFKB3;AIB1 BHLHE42 RAC3 TRAM1
1055	ZNF198-PML complex	Human	None	None	P29590;Q9UBW7	5371;7750	MI:0019-coimmunoprecipitation	GO:2001141;GO:0006355;GO:0005634	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;nucleus	11.02.03.04;70.10	transcriptional control;nucleus	17027752	The authors show by coimmunoprecipitation that PML and sumoylated ZNF198 are in a protein complex in the cell.	ZMYM2 is involved in myeloproliferative disorder.	None	Homo sapiens (Human);Homo sapiens (Human)	Protein PML;Zinc finger MYM-type protein 2	PML;ZMYM2	MYL PP8675 RNF71 TRIM19;FIM RAMP ZNF198
1056	ZNF198-SUMO1 complex	Human	None	HEK293 cells	P63165;Q9UBW7	7341;7750	MI:0018-two hybrid;MI:0019-coimmunoprecipitation	GO:2001141;GO:0006355;GO:0005634	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;nucleus	11.02.03.04;70.10	transcriptional control;nucleus	17027752	The results show that ZNF198 is covalently modified by SUMO-1.	ZMYM2 is involved in myeloproliferative disorder.	None	Homo sapiens (Human);Homo sapiens (Human)	Small ubiquitin-related modifier 1;Zinc finger MYM-type protein 2	SUMO1;ZMYM2	SMT3C SMT3H3 UBL1;FIM RAMP ZNF198
1057	DIPA-MCRS1 complex	Human	None	None	Q15834;Q96EZ8	11007;10445	MI:0019-coimmunoprecipitation	GO:0045892;GO:0005694	negative regulation of DNA-templated transcription;chromosome	11.02.03.04.03;70.10.03	transcription repression;chromosome	17014843	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Coiled-coil domain-containing protein 85B;Microspherule protein 1	CCDC85B;MCRS1	DIPA;INO80Q MSP58
1058	SNX complex (SNX1, SNX6)	Human	None	HeLa cells	Q13596;Q9UNH7	6642;58533	MI:0019-coimmunoprecipitation	GO:0000301;GO:0005768	retrograde transport, vesicle recycling within Golgi;endosome	20.09.07.07;70.22	retrograde transport;endosome	17148574	SNX1 and SNX6 exist in a stable, endosomally associated complex that is required for retromer-mediated retrieval of the cation-independent mannose-6-phosphate receptor.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Sorting nexin-1;Sorting nexin-6	SNX1;SNX6	None;None
1060	Retromer complex (SNX1, SNX2, VPS35, VPS29, VPS26B)	Human	None	in vitro	O60749;Q13596;Q4G0F5;Q96QK1;Q9UBQ0	6643;6642;112936;55737;51699	MI:0018-two hybrid;MI:0019-coimmunoprecipitation;MI:0047-far western blotting;MI:0091-chromatography technology	GO:0000301	retrograde transport, vesicle recycling within Golgi	20.09.07.07	retrograde transport	11102511	None	None	human genes expressed in COS7 cells	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Sorting nexin-2;Sorting nexin-1;Vacuolar protein sorting-associated protein 26B;Vacuolar protein sorting-associated protein 35;Vacuolar protein sorting-associated protein 29	SNX2;SNX1;VPS26B;VPS35;VPS29	None;None;None;MEM3;None
1062	BAR-BCL2-CASP8 complex	Human	None	None	P10415;Q14790;Q9NZS9	596;841;51283	MI:0019-coimmunoprecipitation	GO:0006915	apoptotic process	40.10.02	apoptosis (type I programmed cell death)	10716992	BAR can bridge procaspase-8 and Bcl-2 into a protein complex. The BAR protein is anchored in intracellular membranes where Bcl-2 resides. BAR therefore may represent a scaffold protein capable of bridging two major apoptosis pathways (intrinsic and extrinsic).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Apoptosis regulator Bcl-2;Caspase-8;Bifunctional apoptosis regulator	BCL2;CASP8;BFAR	None;MCH5;BAR RNF47
1063	GRASP-GRP1 complex	Human	None	None	O43739;Q7Z6J2	9265;160622	MI:0019-coimmunoprecipitation	GO:0007264;GO:0005886	small GTPase mediated signal transduction;plasma membrane	30.01.05.05.01;70.02	small GTPase mediated signal transduction;eukaryotic plasma membrane / membrane attached	10828067	The authors propose that GRASP may aid in the localization of GRP1 to discrete signaling networks and facilitate stimulation of ARF-mediated events at the plasma membrane.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cytohesin-3;Protein TAMALIN	CYTH3;TAMALIN	ARNO3 GRP1 PSCD3;GRASP
1064	IFP35-NMI complex	Human	None	None	P80217;Q13287	3430;9111	MI:0018-two hybrid;MI:0019-coimmunoprecipitation;MI:0071-molecular sieving	GO:0043161;GO:0006511	proteasome-mediated ubiquitin-dependent protein catabolic process;ubiquitin-dependent protein catabolic process	14.13.01.01	proteasomal degradation (ubiquitin/proteasomal pathway)	10950963	The authors show that IFP 35 is degraded in a proteasome-mediated process, and that a novel function of Nmi is to prevent IFP 35 degradation.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Interferon-induced 35 kDa protein;N-myc-interactor	IFI35;NMI	IFP35;None
1067	CD8A-LCK complex	Human	None	None	P01732;P06239	925;3932	MI:0019-coimmunoprecipitation	GO:0007169;GO:0006955;GO:0005886	transmembrane receptor protein tyrosine kinase signaling pathway;immune response;plasma membrane	30.05.01.12;36.25.16;70.02	transmembrane receptor protein tyrosine kinase signalling pathways;immune response;eukaryotic plasma membrane / membrane attached	11034334	The authors found that newly synthesized p56lck binds rapidly to CD8-alpha throughout the exocytic pathway and about 50% of complexed p56lck reaches the cell surface.	None	None	Homo sapiens (Human);Homo sapiens (Human)	T-cell surface glycoprotein CD8 alpha chain;Tyrosine-protein kinase Lck	CD8A;LCK	MAL;None
1068	12S U11 snRNP	Human	None	None	P14678;P62304;P62306;P62308;P62314;P62316;P62318;P67809;Q16560;Q16629;Q6IEG0;Q8N8D1;Q96GM8;Q9BV90;Q9H875	6628;6635;6636;6637;6632;6633;6634;4904;11066;6432;154007;10081;114034;79622;79706	MI:0029-cosedimentation through density gradient;MI:0069-mass spectrometry studies of complexes	GO:0000398;GO:0006397;GO:0005634	mRNA splicing, via spliceosome;mRNA processing;nucleus	11.04.03;70.10	mRNA processing (splicing, 5'-, 3'-end processing);nucleus	15146077	U12-type spliceosomes excise U12-type introns, which comprise less than 1% of all human introns.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Small nuclear ribonucleoprotein-associated proteins B and B';Small nuclear ribonucleoprotein E;Small nuclear ribonucleoprotein F;Small nuclear ribonucleoprotein G;Small nuclear ribonucleoprotein Sm D1;Small nuclear ribonucleoprotein Sm D2;Small nuclear ribonucleoprotein Sm D3;Y-box-binding protein 1;U11/U12 small nuclear ribonucleoprotein 35 kDa protein;Serine/arginine-rich splicing factor 7;U11/U12 small nuclear ribonucleoprotein 48 kDa protein;Programmed cell death protein 7;Target of EGR1 protein 1;U11/U12 small nuclear ribonucleoprotein 25 kDa protein;PRKR-interacting protein 1	SNRPB;SNRPE;SNRPF;SNRPG;SNRPD1;SNRPD2;SNRPD3;YBX1;SNRNP35;SRSF7;SNRNP48;PDCD7;TOE1;SNRNP25;PRKRIP1	COD SNRPB1;None;PBSCF;PBSCG;None;SNRPD1;None;NSEP1 YB1;HM1 U1SNRNPBP;SFRS7;C6orf151;None;;C16orf33;
1069	FIF-FGR2 complex	Human	None	None	P09038;Q9BZZ5	2247;8539	MI:0018-two hybrid;MI:0019-coimmunoprecipitation	GO:0005515	protein binding	16.01	protein binding	11075807	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Fibroblast growth factor 2;Apoptosis inhibitor 5	FGF2;API5	FGFB;None
1070	SNX1-SNX2 complex	Human	None	human SNX expressed in COS7 cells	O60749-1;Q13596-1	6643;6642	MI:0019-coimmunoprecipitation	GO:0015031	protein transport	20.01.10	protein transport	9819414	SNX2 forms heteromeric complexes with SNX1, SNX1A, and SNX4 but not with SNX3.	None	SNX2 (519 aa) and SNX1 (522 aa) are splice variants/isoforms	Homo sapiens (Human);Homo sapiens (Human)	Isoform 1 of Sorting nexin-2;Isoform 1 of Sorting nexin-1	SNX2;SNX1	None;None
1071	PKD2-FPC complex	Human	None	epithelium, kidney, heart muscle	P08F94;Q13563	5314;5311	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0006812;GO:0005216;GO:0006875;GO:0005929	cation transport;ion channel activity;cellular metal ion homeostasis;cilium	20.01.01.01;20.03.01.01;34.01.01.01	cation transport (H+, Na+, K+, Ca2+ , NH4+, etc.);ion channels;homeostasis of metal ions (Na, K, Ca etc.)	17008358	The study shows that fibrocystin is another partner of PC2, which functionally up-regulates its channel function through KIF3B. Interestingly, although KIF3B directly binds PC2, it has no significant effect on PC2 channel function, indicating that it primarily serves as a linker protein.	PKD2-FPC complex is involved in polycystic kidney disease (PKD).	None	Homo sapiens (Human);Homo sapiens (Human)	Fibrocystin;Polycystin-2	PKHD1;PKD2	FCYT TIGM1;TRPP2
1072	SNX2 homo-oligomer complex	Human	None	human SNX expressed in COS7 cells	O60749-1	6643	MI:0019-coimmunoprecipitation	GO:0005154;GO:0005158;GO:1990460;GO:0042803;GO:0048407	epidermal growth factor receptor binding;insulin receptor binding;leptin receptor binding;protein homodimerization activity;platelet-derived growth factor binding	None	None	9819414	None	None	SNX2 (519 aa = splice variant/isoform) is able to oligomerize with itself. The exact number of components is not mentioned in paper.	Homo sapiens (Human)	Isoform 1 of Sorting nexin-2	SNX2	None
1079	P-TEFb.1 complex	Human	transcription elongation factor b.1 complex	HeLa nuclear extract	O60563;P50750	904;1025	MI:0007-anti tag coimmunoprecipitation	GO:0006354;GO:0045893;GO:0005634;GO:0070816	DNA-templated transcription elongation;positive regulation of DNA-templated transcription;nucleus;phosphorylation of RNA polymerase II C-terminal domain	11.02.03.01.04;11.02.03.04.01;70.10	transcription elongation;transcription activation;nucleus	9499409	Cyclin T activates CDK9 in the P-TEFb complex. P-TEFb works as a protein kinase that phosphorylates the C-terminal domain of the RNAPII largest subunit.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cyclin-T1;Cyclin-dependent kinase 9	CCNT1;CDK9	None;CDC2L4 TAK
1080	P-TEFb.2 complex	Human	transcription elongation factor b.2 complex	None	O60583;P50750	905;1025	MI:0007-anti tag coimmunoprecipitation	GO:0006354;GO:0045893;GO:0005634;GO:0070816	DNA-templated transcription elongation;positive regulation of DNA-templated transcription;nucleus;phosphorylation of RNA polymerase II C-terminal domain	11.02.03.01.04;11.02.03.04.01;70.10	transcription elongation;transcription activation;nucleus	9499409	Cyclin T activates CDK9 in the P-TEFb complex. P-TEFb works as a protein kinase that phosphorylates the C-terminal domain of the RNAPII largest subunit.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cyclin-T2;Cyclin-dependent kinase 9	CCNT2;CDK9	None;CDC2L4 TAK
1083	P-TEFb.4 complex	Human	transcription elongation factor b.4 complex	None	O75909;P50750	8812;1025	MI:0018-two hybrid;MI:0071-molecular sieving	GO:0006354;GO:0045893;GO:0005634;GO:0070816	DNA-templated transcription elongation;positive regulation of DNA-templated transcription;nucleus;phosphorylation of RNA polymerase II C-terminal domain	11.02.03.01.04;11.02.03.04.01;70.10	transcription elongation;transcription activation;nucleus	10574912	Cyclin K functions as regulatory subunit of CDK9.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cyclin-K;Cyclin-dependent kinase 9	CCNK;CDK9	CPR4;CDC2L4 TAK
1085	DNA repair complex NEIL2-PNK-Pol(beta)-LigIII(alpha)-XRCC1	Human	None	None	O00764;P06746;P18887;P49916;Q969S2	8566;5423;7515;3980;252969	MI:0006-anti bait coimmunoprecipitation	GO:0006281;GO:0003677;GO:0005634	DNA repair;DNA binding;nucleus	10.01.05.01;16.03.01;70.10	DNA repair;DNA binding;nucleus	16982218	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Pyridoxal kinase;DNA polymerase beta;DNA repair protein XRCC1;DNA ligase 3;Endonuclease 8-like 2	PDXK;POLB;XRCC1;LIG3;NEIL2	C21orf124 C21orf97 PKH PNK;None;None;None;None
1086	DNA repair complex NEIL1-PNK-Pol(beta)-LigIII(alpha)-XRCC1	Human	None	None	O00764;P06746;P18887;P49916;Q96FI4	8566;5423;7515;3980;79661	MI:0006-anti bait coimmunoprecipitation	GO:0006281;GO:0003677;GO:0005634	DNA repair;DNA binding;nucleus	10.01.05.01;16.03.01;70.10	DNA repair;DNA binding;nucleus	15260972	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Pyridoxal kinase;DNA polymerase beta;DNA repair protein XRCC1;DNA ligase 3;Endonuclease 8-like 1	PDXK;POLB;XRCC1;LIG3;NEIL1	C21orf124 C21orf97 PKH PNK;None;None;None;None
1087	BIRC5-AURKB-INCENP-EVI5 complex	Human	None	None	O15392;O60447;Q96GD4;Q9NQS7	332;7813;9212;3619	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0000910;GO:0000917	cytokinesis;division septum assembly	10.03.03	cytokinesis (cell division) /septum formation and hydrolysis	16764853	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Baculoviral IAP repeat-containing protein 5;Ecotropic viral integration site 5 protein homolog;Aurora kinase B;Inner centromere protein	BIRC5;EVI5;AURKB;INCENP	API4 IAP4;NB4S;AIK2 AIM1 AIRK2 ARK2 STK1 STK12 STK5;None
1088	PRNP-ApolopoproteinE3 complex	Human	None	None	P04156;Q13791	5621;348	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0005515	protein binding	16.01	protein binding	16764853	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Major prion protein;Apolipoprotein E3	PRNP;None	ALTPRP PRIP PRP;None
1089	VAM1-VELI1 complex	Human	None	epithelium, nervous tissue	O14910;Q9NZW5	8825;51678	MI:0096-pull down	GO:0065003	protein-containing complex assembly	None	None	11311936	VAM-1 may function by promoting the assembly of a Veli-1 containing protein complex in neuronal as well as epithelial cells (PMID:11311936).	None	None	Homo sapiens (Human);Homo sapiens (Human)	Protein lin-7 homolog A;Protein PALS2	LIN7A;PALS2	MALS1 VELI1;MPP6 VAM1
1090	AP1G1-RABEP1 complex	Human	APLG1-Rababtin5 complex	HeLa cells	O43747;Q15276	164;9135	MI:0018-two hybrid;MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0016192;GO:0005802	vesicle-mediated transport;trans-Golgi network	20.09.07	vesicular transport (Golgi network, etc.)	11872161	Gamma1-adaptin is a subunit of the AP-1 adaptor complex of clathrin-coated vesicles derived from the trans-Golgi network (TGN). The gamma1-adaptin-Rabaptin-5 complex may play a role in membrane trafficking between the TGN and endosomes.	None	None	Homo sapiens (Human);Homo sapiens (Human)	AP-1 complex subunit gamma-1;Rab GTPase-binding effector protein 1	AP1G1;RABEP1	ADTG CLAPG1;RAB5EP RABPT5 RABPT5A
1091	LEPR-SNX1 complex	Human	LEPR-B - SNX1 complex; LEPR (long isoform) - SNX1 complex	human SNX expressed in COS7 cells	P48357-1;Q13596-1	None;6642	MI:0019-coimmunoprecipitation	GO:0038021;GO:1990460	leptin receptor activity;leptin receptor binding	None	None	9819414	SNX1, SNX1A, SNX2, and SNX4 coimmunoprecipitated with the long form of the leptin receptor, but not with the short and medium isoforms. SNX3 was not found to associate with any of the receptors studied.	None	SNX1 = splice variant/isoform; LEPR B is the long splice variant/isoform of LEPR;	Homo sapiens (Human);Homo sapiens (Human)	Isoform B of Leptin receptor;Isoform 1 of Sorting nexin-1	LEPR;SNX1	DB OBR;None
1092	PCNA-KU antigen complex	Human	PCNA-Ku70-Ku80 complex	None	P12004;P12956;P13010	5111;2547;7520	MI:0006-anti bait coimmunoprecipitation	GO:0006281;GO:0003677;GO:0005524;GO:0006974	DNA repair;DNA binding;ATP binding;cellular response to DNA damage stimulus	10.01.05.01;16.03.01;16.19.03;32.01.09	DNA repair;DNA binding;ATP binding;DNA damage response	11239001	Interaction of PCNA with Ku70 and Ku80 heterodimer increases after DNA damage.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Proliferating cell nuclear antigen;X-ray repair cross-complementing protein 6;X-ray repair cross-complementing protein 5	PCNA;XRCC6;XRCC5	None;G22P1;G22P2
1093	INSR-SNX1 complex	Human	None	human SNX expressed in COS7 cells	P06213;Q13596-1	3643;6642	MI:0019-coimmunoprecipitation;MI:0113-western blot	GO:0008286;GO:0005158	insulin receptor signaling pathway;insulin receptor binding	30.05.01.12.05	insulin receptor signalling pathway	9819414	After incubation of cell extracts with an insulin receptor beta-subunit antibody followed by Western blotting of the precipitates with antibody to the epitope tag, it was found that SNX1, SNX1A, and SNX2 and small amounts of SNX4 coimmunoprecipitated with the insulin receptor.	None	SNX1 (522 aa) = splice variant/isoform;	Homo sapiens (Human);Homo sapiens (Human)	Insulin receptor;Isoform 1 of Sorting nexin-1	INSR;SNX1	None;None
1094	Frataxin complex	Human	None	COS cells	O75964;P10809;P31040;P38646;Q16595;Q9HD34;Q9Y4W6	10632;3329;6389;3313;2395;57128;10939	MI:0019-coimmunoprecipitation	GO:0005515;GO:0005739	protein binding;mitochondrion	16.01;70.16	protein binding;mitochondrion	17331979	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	ATP synthase subunit g, mitochondrial;60 kDa heat shock protein, mitochondrial;Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial;Stress-70 protein, mitochondrial;Frataxin, mitochondrial;LYR motif-containing protein 4;AFG3-like protein 2	ATP5MG;HSPD1;SDHA;HSPA9;FXN;LYRM4;AFG3L2	ATP5L;HSP60;SDH2 SDHF;GRP75 HSPA9B mt-HSP70;FRDA X25;C6orf149 ISD11;None
1095	EGFR-SNX1 complex	Human	None	human SNX expressed in COS7 cells	P00533;Q13596-1	1956;6642	MI:0019-coimmunoprecipitation;MI:0113-western blot	GO:0007173;GO:0005154	epidermal growth factor receptor signaling pathway;epidermal growth factor receptor binding	30.05.01.12.01	EGF-receptor signalling pathway	9819414	In extracts from cells overexpressing EGF receptors and the various sorting nexins, it was found that SNX1 and SNX1A were readily detected in EGF receptor immunoprecipitates. SNX2 and SNX4 were detected, but to a lesser degree, and SNX3 was undetectable.	None	SNX1 = splice variant/isoform;	Homo sapiens (Human);Homo sapiens (Human)	Epidermal growth factor receptor;Isoform 1 of Sorting nexin-1	EGFR;SNX1	ERBB ERBB1 HER1;None
1096	PDGFRB-SNX1 complex	Human	None	human SNX expressed in COS7 cells	P09619;Q13596-1	5159;6642	MI:0019-coimmunoprecipitation;MI:0113-western blot	GO:0005161;GO:0005017	platelet-derived growth factor receptor binding;platelet-derived growth factor receptor activity	None	None	9819414	SNX1, SNX1A, and SNX2 were readily coimmunoprecipitated with PDGF receptors (beta isoform), while SNX4 was coimmunoprecipitated to a lesser extent. As with the insulin receptor and EGF receptor, no association was detectable between the PDGF receptor and SNX3.	None	SNX1 is a splice variant/isoform;	Homo sapiens (Human);Homo sapiens (Human)	Platelet-derived growth factor receptor beta;Isoform 1 of Sorting nexin-1	PDGFRB;SNX1	PDGFR PDGFR1;None
1097	eIF3 complex (EIF3S6, EIF3S5, EIF3S4, EIF3S3, EIF3S6IP, EIF3S2, EIF3S9, EIF3S12,  EIF3S10, EIF3S8,  EIF3S1, EIF3S7, PCID1)	Human	None	None	O00303;O15371;O15372;O75821;O75822;P55884;P60228;Q13347;Q14152;Q7L2H7;Q99613;Q9UBQ5;Q9Y262	8665;8664;8667;8666;8669;8662;3646;8668;8661;10480;8663;27335;51386	MI:0069-mass spectrometry studies of complexes	GO:0006413	translational initiation	12.04.01	translation initiation	17322308	Four eIF3 subunits (h, i, k, and m) were found to dissociate preferentially and are therefore likely to be on the periphery of the complex (PMID:17322308).	None	Each of 13 subunits of this complex present in stoichiometric amounts (PMID:17322308).	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Eukaryotic translation initiation factor 3 subunit F;Eukaryotic translation initiation factor 3 subunit D;Eukaryotic translation initiation factor 3 subunit H;Eukaryotic translation initiation factor 3 subunit G;Eukaryotic translation initiation factor 3 subunit J;Eukaryotic translation initiation factor 3 subunit B;Eukaryotic translation initiation factor 3 subunit E;Eukaryotic translation initiation factor 3 subunit I;Eukaryotic translation initiation factor 3 subunit A;Eukaryotic translation initiation factor 3 subunit M;Eukaryotic translation initiation factor 3 subunit C;Eukaryotic translation initiation factor 3 subunit K;Eukaryotic translation initiation factor 3 subunit L	EIF3F;EIF3D;EIF3H;EIF3G;EIF3J;EIF3B;EIF3E;EIF3I;EIF3A;EIF3M;EIF3C;EIF3K;EIF3L	EIF3S5;EIF3S7;EIF3S3;EIF3S4;EIF3S1;EIF3S9;EIF3S6 INT6;EIF3S2 TRIP1;EIF3S10 KIAA0139;HFLB5 PCID1;EIF3S8;EIF3S12;EIF3EIP EIF3S6IP
1098	DNA synthesome complex (13 subunits)	Human	None	None	P09884;P11387;P11388;P12004;P27694;P28340;P35251;P49005;P49642;P49643;Q14181;Q15054;Q9HCU8	5422;7150;7153;5111;6117;5424;5981;5425;5557;5558;23649;10714;57804	MI:0029-cosedimentation through density gradient;MI:0226-ion exchange chromatography	GO:0006260;GO:0005634	DNA replication;nucleus	10.01.03;70.10	DNA synthesis and replication;nucleus	9279361	None	None	Since the authors did not specify TOP2, we used TOP2A.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA polymerase alpha catalytic subunit;DNA topoisomerase 1;DNA topoisomerase 2-alpha;Proliferating cell nuclear antigen;Replication protein A 70 kDa DNA-binding subunit;DNA polymerase delta catalytic subunit;Replication factor C subunit 1;DNA polymerase delta subunit 2;DNA primase small subunit;DNA primase large subunit;DNA polymerase alpha subunit B;DNA polymerase delta subunit 3;DNA polymerase delta subunit 4	POLA1;TOP1;TOP2A;PCNA;RPA1;POLD1;RFC1;POLD2;PRIM1;PRIM2;POLA2;POLD3;POLD4	POLA;None;TOP2;None;REPA1 RPA70;POLD;RFC140;None;None;PRIM2A;None;KIAA0039;POLDS
1100	DNA polymerase alpha-primase complex	Human	None	None	P09884;P49642;P49643;Q14181	5422;5557;5558;23649	MI:0226-ion exchange chromatography	GO:0006267;GO:0003688;GO:0005634	pre-replicative complex assembly involved in nuclear cell cycle DNA replication;DNA replication origin binding;nucleus	10.01.03.03;70.10	ori recognition and priming complex formation;nucleus	12220650	DNA polymerase alpha-primase can initiate DNA synthesis de novo.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA polymerase alpha catalytic subunit;DNA primase small subunit;DNA primase large subunit;DNA polymerase alpha subunit B	POLA1;PRIM1;PRIM2;POLA2	POLA;None;PRIM2A;None
1104	SNX1-TFRC complex	Human	None	human SNX expressed in COS7 cells	P02786;Q13596-1	7037;6642	MI:0019-coimmunoprecipitation;MI:0113-western blot	GO:0004998;GO:1990459	transferrin receptor activity;transferrin receptor binding	None	None	9819414	Only SNX1 and SNX1A coimmunoprecipitated with endogenous transferrin receptors. Association between endogenous transferrin receptors and SNX2, SNX3, or SNX4 were not detected.	None	SNX1 = splice variant/isoform;	Homo sapiens (Human);Homo sapiens (Human)	Transferrin receptor protein 1;Isoform 1 of Sorting nexin-1	TFRC;SNX1	None;None
1105	transcription factor IIIC multisubunit complex	Human	TFIIIC complex	HeLa S3 cells	Q12789;Q8WUA4;Q9UKN8;Q9Y5Q8;Q9Y5Q9	2975;2976;9329;9328;9330	MI:0029-cosedimentation through density gradient	GO:2001141;GO:0006355;GO:0003677;GO:0005634	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;DNA binding;nucleus	11.02.03.04;16.03.01;70.10	transcriptional control;DNA binding;nucleus	9660958	The authors differentiate two forms of the isolated complexes, the sucrose gradient centrifugation isolated complex and the immunopurified complex of Hela S3 cell line (C alpha 12), which is called holo TFIIIC. Only the holo TFIIIC shows the further additional components topo I and PC4.	None	At the time of annotation, the additional members of subcomplex TFIIIC1, 70 kDa, 50 kDa, 45kDa and 40 kDa protein were unidentified.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	General transcription factor 3C polypeptide 1;General transcription factor 3C polypeptide 2;General transcription factor 3C polypeptide 4;General transcription factor 3C polypeptide 5;General transcription factor 3C polypeptide 3	GTF3C1;GTF3C2;GTF3C4;GTF3C5;GTF3C3	None;KIAA0011;None;None;None
1106	TFIIIC containing-TOP1-SUB1 complex	Human	None	HeLa S3 cells	P11387;P53999;Q12789;Q8WUA4;Q9UKN8;Q9Y5Q8;Q9Y5Q9	7150;10923;2975;2976;9329;9328;9330	MI:0007-anti tag coimmunoprecipitation	GO:2001141;GO:0006355;GO:0003677;GO:0005634	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;DNA binding;nucleus	11.02.03.04;16.03.01;70.10	transcriptional control;DNA binding;nucleus	9660958	The authors differentiate two forms of the isolated complexes, the sucrose gradient centrifugation isolated complex and the immunopurified complex of Hela S3 cell line (C alpha 12), which is called holo TFIIIC. Only the holo TFIIIC shows the further additional components topo I and PC4.	None	At the time of annotation, the additional members of subcomplex TFIIIC1, 70 kDa, 50 kDa, 45kDa -and 40 kDa protein were unidentified.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA topoisomerase 1;Activated RNA polymerase II transcriptional coactivator p15;General transcription factor 3C polypeptide 1;General transcription factor 3C polypeptide 2;General transcription factor 3C polypeptide 4;General transcription factor 3C polypeptide 5;General transcription factor 3C polypeptide 3	TOP1;SUB1;GTF3C1;GTF3C2;GTF3C4;GTF3C5;GTF3C3	None;PC4 RPO2TC1;None;KIAA0011;None;None;None
1107	DNA synthesome core complex	Human	None	None	P09884;P12004;P28340;P35251;P49005;P49642;P49643;Q14181;Q15054;Q9HCU8	5422;5111;5424;5981;5425;5557;5558;23649;10714;57804	MI:0029-cosedimentation through density gradient;MI:0226-ion exchange chromatography	GO:0006260;GO:0005634	DNA replication;nucleus	10.01.03;70.10	DNA synthesis and replication;nucleus	9563011	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA polymerase alpha catalytic subunit;Proliferating cell nuclear antigen;DNA polymerase delta catalytic subunit;Replication factor C subunit 1;DNA polymerase delta subunit 2;DNA primase small subunit;DNA primase large subunit;DNA polymerase alpha subunit B;DNA polymerase delta subunit 3;DNA polymerase delta subunit 4	POLA1;PCNA;POLD1;RFC1;POLD2;PRIM1;PRIM2;POLA2;POLD3;POLD4	POLA;None;POLD;RFC140;None;None;PRIM2A;None;KIAA0039;POLDS
1108	DNA synthesome complex (15 subunits)	Human	None	None	P09884;P12004;P18858;P28340;P35251;P49005;P49642;P49643;P56282;Q07864;Q14181;Q15054;Q9HCU8;Q9NR33;Q9NRF9	5422;5111;3978;5424;5981;5425;5557;5558;5427;5426;23649;10714;57804;56655;54107	MI:0006-anti bait coimmunoprecipitation;MI:0029-cosedimentation through density gradient;MI:0226-ion exchange chromatography	GO:0006260;GO:0005634	DNA replication;nucleus	10.01.03;70.10	DNA synthesis and replication;nucleus	9563011	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA polymerase alpha catalytic subunit;Proliferating cell nuclear antigen;DNA ligase 1;DNA polymerase delta catalytic subunit;Replication factor C subunit 1;DNA polymerase delta subunit 2;DNA primase small subunit;DNA primase large subunit;DNA polymerase epsilon subunit 2;DNA polymerase epsilon catalytic subunit A;DNA polymerase alpha subunit B;DNA polymerase delta subunit 3;DNA polymerase delta subunit 4;DNA polymerase epsilon subunit 4;DNA polymerase epsilon subunit 3	POLA1;PCNA;LIG1;POLD1;RFC1;POLD2;PRIM1;PRIM2;POLE2;POLE;POLA2;POLD3;POLD4;POLE4;POLE3	POLA;None;None;POLD;RFC140;None;None;PRIM2A;DPE2;POLE1;None;KIAA0039;POLDS;None;CHRAC17
1111	DNA synthesome complex (17 subunits)	Human	None	MCF7 cells	P09884;P11387;P11388;P12004;P27694;P28340;P35251;P49005;P49642;P49643;P56282;Q07864;Q14181;Q15054;Q9HCU8;Q9NR33;Q9NRF9	5422;7150;7153;5111;6117;5424;5981;5425;5557;5558;5427;5426;23649;10714;57804;56655;54107	MI:0029-cosedimentation through density gradient;MI:0226-ion exchange chromatography;MI:0276-blue native page	GO:0006260;GO:0005634	DNA replication;nucleus	10.01.03;70.10	DNA synthesis and replication;nucleus	11968016	This complex associates also with a not further characterized DNA helicase.	None	Since the authors did not specify TOP2, we used TOP2A.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA polymerase alpha catalytic subunit;DNA topoisomerase 1;DNA topoisomerase 2-alpha;Proliferating cell nuclear antigen;Replication protein A 70 kDa DNA-binding subunit;DNA polymerase delta catalytic subunit;Replication factor C subunit 1;DNA polymerase delta subunit 2;DNA primase small subunit;DNA primase large subunit;DNA polymerase epsilon subunit 2;DNA polymerase epsilon catalytic subunit A;DNA polymerase alpha subunit B;DNA polymerase delta subunit 3;DNA polymerase delta subunit 4;DNA polymerase epsilon subunit 4;DNA polymerase epsilon subunit 3	POLA1;TOP1;TOP2A;PCNA;RPA1;POLD1;RFC1;POLD2;PRIM1;PRIM2;POLE2;POLE;POLA2;POLD3;POLD4;POLE4;POLE3	POLA;None;TOP2;None;REPA1 RPA70;POLD;RFC140;None;None;PRIM2A;DPE2;POLE1;None;KIAA0039;POLDS;None;CHRAC17
1113	5S-DNA-TFIIIA-TFIIIC2 subcomplex	Human	None	None	Q12789;Q8WUA4;Q92664;Q9UKN8;Q9Y5Q8;Q9Y5Q9	2975;2976;2971;9329;9328;9330	MI:0004-affinity chromatography technology;MI:0071-molecular sieving	GO:2001141;GO:0006355;GO:0003677;GO:0005634	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;DNA binding;nucleus	11.02.03.04;16.03.01;70.10	transcriptional control;DNA binding;nucleus	12711686	This complex could be complemented with TFIIIB beta, TFIIIC1 and RNA polymerase III (pol III) for transcriptional activity.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	General transcription factor 3C polypeptide 1;General transcription factor 3C polypeptide 2;Transcription factor IIIA;General transcription factor 3C polypeptide 4;General transcription factor 3C polypeptide 5;General transcription factor 3C polypeptide 3	GTF3C1;GTF3C2;GTF3A;GTF3C4;GTF3C5;GTF3C3	None;KIAA0011;None;None;None;None
1114	5S-DNA-TFIIIA-TFIIIC2-TFIIIB subcomplex	Human	None	None	A6H8Y1;P20226;Q12789;Q8WUA4;Q92664;Q92994;Q9UKN8;Q9Y5Q8;Q9Y5Q9	55814;6908;2975;2976;2971;2972;9329;9328;9330	MI:0004-affinity chromatography technology;MI:0071-molecular sieving	GO:2001141;GO:0006355;GO:0003677;GO:0005634	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;DNA binding;nucleus	11.02.03.04;16.03.01;70.10	transcriptional control;DNA binding;nucleus	12711686	This complex has to be complemented with TFIIIC1 and RNA polymerase III (pol III) for full transcriptional activity. Adding pol III to an isolated quaternary 5S-DNA-TFIIIA-TFIIIC2-TFIIIB-beta complex does not suffice for transcription, but the further addition of TFIIIC1 is absolutely required.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transcription factor TFIIIB component B'' homolog;TATA-box-binding protein;General transcription factor 3C polypeptide 1;General transcription factor 3C polypeptide 2;Transcription factor IIIA;Transcription factor IIIB 90 kDa subunit;General transcription factor 3C polypeptide 4;General transcription factor 3C polypeptide 5;General transcription factor 3C polypeptide 3	BDP1;TBP;GTF3C1;GTF3C2;GTF3A;BRF1;GTF3C4;GTF3C5;GTF3C3	KIAA1241 KIAA1689 TFNR;GTF2D1 TF2D TFIID;None;KIAA0011;None;BRF GTF3B TAF3B2 TAF3C;None;None;None
1116	AURKB-BIRC5-XPO1 complex	Human	CRM1-Survivin-AuroraB mitotic complex	HeLa cells	O14980;O15392;Q96GD4	7514;332;9212	MI:0006-anti bait coimmunoprecipitation	GO:0000278;GO:0000775	mitotic cell cycle;chromosome, centromeric region	10.03.01.01;70.10.04	mitotic cell cycle;centromere / kinetochore	17099693	Crm1 could be recovered in a complex with endogenous Survivin-Aurora-B from mitotic cells, whereas complex formation was abolished on pretreatment with LMB (leptomycin B).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Exportin-1;Baculoviral IAP repeat-containing protein 5;Aurora kinase B	XPO1;BIRC5;AURKB	CRM1;API4 IAP4;AIK2 AIM1 AIRK2 ARK2 STK1 STK12 STK5
1117	BIRC5-XPO1 complex	Human	CRM1-Survivin mitotic complex	HeLa cells	O14980;O15392	7514;332	MI:0007-anti tag coimmunoprecipitation	GO:0000278;GO:0000775	mitotic cell cycle;chromosome, centromeric region	10.03.01.01;70.10.04	mitotic cell cycle;centromere / kinetochore	17099693	The Survivin-Crm1 interaction is essential for chromosomal passenger complex localization and function.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Exportin-1;Baculoviral IAP repeat-containing protein 5	XPO1;BIRC5	CRM1;API4 IAP4
1118	Chromosomal passenger complex CPC (INCENP, CDCA8, BIRC5, AURKB)	Human	None	HeLa cells	O15392;Q53HL2;Q96GD4;Q9NQS7	332;55143;9212;3619	MI:0007-anti tag coimmunoprecipitation	GO:0000278;GO:0007059;GO:0000775	mitotic cell cycle;chromosome segregation;chromosome, centromeric region	10.03.01.01;10.03.04.05;70.10.04	mitotic cell cycle;chromosome segregation/division;centromere / kinetochore	17099693	Borealin forms a complex with Survivin, which can bind to Aurora-B kinase and is incorporated into the CP-holocomplex by interacting with INCENP (PMID:16571674). The NES in Survivin mediates the recruitment of Crm1-Ran-GTP, which seems to be involved in guiding the CPC to the centromeres in early prophase by an unknown mechanism.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Baculoviral IAP repeat-containing protein 5;Borealin;Aurora kinase B;Inner centromere protein	BIRC5;CDCA8;AURKB;INCENP	API4 IAP4;PESCRG3;AIK2 AIM1 AIRK2 ARK2 STK1 STK12 STK5;None
1119	Chromosomal passenger complex CPC (INCENP, CDCA8, BIRC5, AURKB)	Human	None	None	O15392;Q53HL2;Q96GD4;Q9NQS7	332;55143;9212;3619	MI:0007-anti tag coimmunoprecipitation	GO:0000278;GO:0007059;GO:0000775;GO:0051225	mitotic cell cycle;chromosome segregation;chromosome, centromeric region;spindle assembly	10.03.01.01;10.03.04.05;70.10.04;10.03.05.01	mitotic cell cycle;chromosome segregation/division;centromere / kinetochore;spindle pole body/centrosome and microtubule cycle	16571674	Yeast two hybrid analysis pointed out that Aurora B associates with the C terminus of INCENP via the IN-box, Survivin and Borealin interact with the N-terminal 58 amino acids of INCENP and bind to each other.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Baculoviral IAP repeat-containing protein 5;Borealin;Aurora kinase B;Inner centromere protein	BIRC5;CDCA8;AURKB;INCENP	API4 IAP4;PESCRG3;AIK2 AIM1 AIRK2 ARK2 STK1 STK12 STK5;None
1120	Chromosomal passenger complex CPC (INCENP, CDCA8, BIRC5)	Human	None	None	O15392;Q53HL2;Q9NQS7	332;55143;3619	MI:0007-anti tag coimmunoprecipitation	GO:0000278;GO:0007059;GO:0000775;GO:0051225	mitotic cell cycle;chromosome segregation;chromosome, centromeric region;spindle assembly	10.03.01.01;10.03.04.05;70.10.04;10.03.05.01	mitotic cell cycle;chromosome segregation/division;centromere / kinetochore;spindle pole body/centrosome and microtubule cycle	16571674	Yeast two hybrid analysis pointed out that Survivin and Borealin interact with the N-terminal 58 amino acids of INCENP and bind to each other. The authors showed that a ternary complex between Borealin, Survivin, and the first 58 amino acids of INCENP (INCENP1-58) exists in vivo. This subcomplex was found to be essential and sufficient for targeting to the centromere. Notably, AuroraB kinase, the enzymatic core of the CPC, was not required for centromere localization of the subcomplex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Baculoviral IAP repeat-containing protein 5;Borealin;Inner centromere protein	BIRC5;CDCA8;INCENP	API4 IAP4;PESCRG3;None
1121	WNK1-OSR1 complex	Human	None	None	O95747;Q9H4A3	9943;65125	MI:0019-coimmunoprecipitation	GO:0005515;GO:0006970;GO:0007588;GO:0030104;GO:0043575	protein binding;response to osmotic stress;excretion;water homeostasis;detection of osmotic stimulus	16.01;34.11.03.13;34.01.05	protein binding;osmosensing  and response;water homeostasis	17190791	WNK1 and OSR1 regulate NKCC activity (sodium, potassium, two chloride cotransporter) (PMID:16832045).	WNK1 is mutated in Gordon's hypertension syndrome.	None	Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein kinase OSR1;Serine/threonine-protein kinase WNK1	OXSR1;WNK1	KIAA1101, OSR1;HSN2 KDP KIAA0344 PRKWNK1
1123	WNK1-SPAK complex	Human	None	None	Q9H4A3;Q9UEW8	65125;27347	MI:0019-coimmunoprecipitation	GO:0006970;GO:0007588;GO:0030104;GO:0043575	response to osmotic stress;excretion;water homeostasis;detection of osmotic stimulus	34.11.03.13;34.01.05	osmosensing  and response;water homeostasis	17190791	None	WNK1 is mutated in Gordon's hypertension syndrome.	None	Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein kinase WNK1;STE20/SPS1-related proline-alanine-rich protein kinase	WNK1;STK39	HSN2 KDP KIAA0344 PRKWNK1;SPAK
1130	Hip1R-cortactin complex	Human	None	None	O75146;Q14247	9026;2017	MI:0007-anti tag coimmunoprecipitation	GO:0005198;GO:0030048;GO:0005737	structural molecule activity;actin filament-based movement;cytoplasm	16.07;20.09.14.02;70.03	structural protein binding;actin dependent transport;cytoplasm	17318189	The Hip1R-cortactin complex negatively regulates actin assembly associated with endocytosis.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Huntingtin-interacting protein 1-related protein;Src substrate cortactin	HIP1R;CTTN	HIP12 KIAA0655;EMS1
1131	RFC2-RIalpha complex	Human	None	None	P30153;P35250	5518;5982	MI:0018-two hybrid;MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0005515	protein binding	16.01	protein binding	15655353	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform;Replication factor C subunit 2	PPP2R1A;RFC2	None;None
1132	RFC2-RIalpha complex	Human	None	None	P30153;P35249	5518;5984	MI:0018-two hybrid;MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0005515	protein binding	16.01	protein binding	15655353	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform;Replication factor C subunit 4	PPP2R1A;RFC4	None;None
1133	ATR-HDAC2 complex	Human	None	None	Q13535;Q92769	545;3066	MI:0004-affinity chromatography technology;MI:0019-coimmunoprecipitation	GO:0006265;GO:0006473;GO:0006476;GO:0051276	DNA topological change;protein acetylation;protein deacetylation;chromosome organization	10.01.09.05;14.07.04;42.10.03	DNA conformation modification (e.g. chromatin);modification by acetylation, deacetylation;organization of chromosome structure	10545197	The ATR-HDAC2 complex is a robust biochemical entity that withstands ammonium sulfate precipitation and anion exchange chromatography.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein kinase ATR;Histone deacetylase 2	ATR;HDAC2	FRP1;None
1134	ATR-HDAC2-CHD4 complex	Human	None	None	Q13535;Q14839;Q92769	545;1108;3066	MI:0019-coimmunoprecipitation;MI:0069-mass spectrometry studies of complexes	GO:0006265;GO:0000075;GO:0006473;GO:0006476;GO:0006974;GO:0051276;GO:0005634	DNA topological change;cell cycle checkpoint signaling;protein acetylation;protein deacetylation;cellular response to DNA damage stimulus;chromosome organization;nucleus	10.01.09.05;10.03.01.03;14.07.04;32.01.09;42.10.03;70.10	DNA conformation modification (e.g. chromatin);cell cycle checkpoints (checkpoints of morphogenesis, DNA-damage,-replication, mitotic phase and spindle);modification by acetylation, deacetylation;DNA damage response;organization of chromosome structure;nucleus	10545197	Other members of the NRD complex HDAC1, MTA-1, and MTA-2 are also detectable in ATR immunoprecipitates.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein kinase ATR;Chromodomain-helicase-DNA-binding protein 4;Histone deacetylase 2	ATR;CHD4;HDAC2	FRP1;None;None
1141	CF IIAm complex (Cleavage factor IIAm complex)	Human	None	None	O43809;O60231;O94913;P19447;P23246;P26368;P26599;P49959;Q01081;Q07157;Q14444;Q16630;Q8N684;Q92759;Q92989;Q9UKF6	11051;8449;51585;2071;6421;11338;5725;4361;7307;7082;4076;11052;79869;2968;10978;51692	MI:0226-ion exchange chromatography	GO:0031123;GO:0031124;GO:0005634	RNA 3'-end processing;mRNA 3'-end processing;nucleus	11.04.03.05;70.10	3'-end processing;nucleus	11060040	Eukaryotic mRNA precursors (pre-mRNAs) undergo a number of processing steps before they are exported to the cytoplasm. Six different protein factors are required in vitro for 3' end formation of mammalian pre-mRNAs by endonucleolytic cleavage and polyadenylation. One of these factors is cleavage factor IIm (CF IIm). During purification of CF IIm, the activity separated into an essential fraction (CF IIAm) and an apparently non-essential, but stimulatory component (CF IIBm).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cleavage and polyadenylation specificity factor subunit 5;Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16;Pre-mRNA cleavage complex 2 protein Pcf11;General transcription and DNA repair factor IIH helicase subunit XPB;Splicing factor, proline- and glutamine-rich;Splicing factor U2AF 65 kDa subunit;Polypyrimidine tract-binding protein 1;Double-strand break repair protein MRE11;Splicing factor U2AF 35 kDa subunit;Tight junction protein ZO-1;Caprin-1;Cleavage and polyadenylation specificity factor subunit 6;Cleavage and polyadenylation specificity factor subunit 7;General transcription factor IIH subunit 4;Polyribonucleotide 5'-hydroxyl-kinase Clp1;Cleavage and polyadenylation specificity factor subunit 3	NUDT21;DHX16;PCF11;ERCC3;SFPQ;U2AF2;PTBP1;MRE11;U2AF1;TJP1;CAPRIN1;CPSF6;CPSF7;GTF2H4;CLP1;CPSF3	CFIM25 CPSF25 CPSF5;DBP2 DDX16 KIAA0577 PRP2;KIAA0824;XPB XPBC;PSF;U2AF65;PTB;HNGS1 MRE11A;U2AF35 U2AFBP;ZO1;GPIAP1 GPIP137 M11S1 RNG105;CFIM68;None;None;HEAB;CPSF73
1143	SMN complex (16 subunits)	Human	None	HeLa cells	O14893;P14678;P57678;P62304;P62306;P62308;P62314;P62316;P62318;Q16637;Q8TEQ6;Q8WXD5;Q9H840;Q9NWZ8;Q9UHI6;Q9Y3F4	8487;6628;50628;6635;6636;6637;6632;6633;6634;None;25929;79833;79760;54960;11218;11171	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0008380;GO:0032774;GO:0003723;GO:0005737;GO:0005634;GO:0065003	RNA splicing;RNA biosynthetic process;RNA binding;cytoplasm;nucleus;protein-containing complex assembly	11.04.03.01;11.02;16.03.03;70.03;70.10	splicing;RNA synthesis;RNA binding;cytoplasm;nucleus	17178713	Assembly of the Sm-class of U-rich small nuclear ribonucleoprotein particles (U snRNPs) is a process facilitated by the macromolecular survival of motor neuron (SMN) complex. Spinal muscular atrophy (SMA) is the most common genetic cause of infant mortality. Deletions or mutations in the survival of motor neurons (SMN1) gene, the SMA-causing gene, are detected in over 95% of SMA patients. The SMN complex is found both in the cytoplasm and in the nucleus, where it is concentrated in gems, nuclear bodies similar in size and number to Cajal (coiled) bodies and often associated with them. Nine factors, including the SMN protein, the product of the spinal muscular atrophy (SMA) disease gene, Gemins 2-8 and unrip have been identified as the major components of the SMN complex. Interaction studies in the present article revealed a framework of the SMN complex with SMN, Gemin7, and Gemin8 as its backbone.	Spinal muscular atrophy (SMA)	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Gem-associated protein 2;Small nuclear ribonucleoprotein-associated proteins B and B';Gem-associated protein 4;Small nuclear ribonucleoprotein E;Small nuclear ribonucleoprotein F;Small nuclear ribonucleoprotein G;Small nuclear ribonucleoprotein Sm D1;Small nuclear ribonucleoprotein Sm D2;Small nuclear ribonucleoprotein Sm D3;Survival motor neuron protein;Gem-associated protein 5;Gem-associated protein 6;Gem-associated protein 7;Gem-associated protein 8;Probable ATP-dependent RNA helicase DDX20;Serine-threonine kinase receptor-associated protein	GEMIN2;SNRPB;GEMIN4;SNRPE;SNRPF;SNRPG;SNRPD1;SNRPD2;SNRPD3;SMN1;GEMIN5;GEMIN6;GEMIN7;GEMIN8;DDX20;STRAP	SIP1;COD SNRPB1;None;None;PBSCF;PBSCG;None;SNRPD1;None;SMN SMNT;None;None;None;FAM51A1;DP103 GEMIN3;MAWD UNRIP
1144	Cleavage and polyadenylation factor (CPSF)	Human	None	None	O95639;Q10570;Q6UN15;Q9P2I0;Q9UKF6	10898;29894;None;53981;51692	MI:0019-coimmunoprecipitation	GO:0031124;GO:0003723;GO:0005515;GO:0005634;GO:1900363	mRNA 3'-end processing;RNA binding;protein binding;nucleus;regulation of mRNA polyadenylation	11.04.03.05;16.03.03;16.01;70.10	3'-end processing;RNA binding;protein binding;nucleus	14749727	In mammals, polyadenylation of mRNA precursors (pre-mRNAs) by poly(A) polymerase (PAP) depends on cleavage and polyadenylation specificity factor (CPSF). CPSF is a multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cleavage and polyadenylation specificity factor subunit 4;Cleavage and polyadenylation specificity factor subunit 1;Pre-mRNA 3'-end-processing factor FIP1;Cleavage and polyadenylation specificity factor subunit 2;Cleavage and polyadenylation specificity factor subunit 3	CPSF4;CPSF1;FIP1L1;CPSF2;CPSF3	CPSF30, NAR, NEB1;CPSF160;FIP1, RHE;CPSF100, KIAA1367;CPSF73
1146	Cleavage stimulation factor	Human	None	None	P33240;Q05048;Q12996	1478;1477;1479	MI:0019-coimmunoprecipitation	GO:0031123;GO:0031124;GO:0003723;GO:0005634	RNA 3'-end processing;mRNA 3'-end processing;RNA binding;nucleus	11.04.03.05;16.03.03;70.10	3'-end processing;RNA binding;nucleus	10669729	Polyadenylation of mRNA precursors is a two-step reaction requiring multiple protein factors. Cleavage stimulation factor (CstF) is a heterotrimer necessary for the first step, endonucleolytic cleavage, and it plays an important role in determining the efficiency of polyadenylation. The cleavage and polyadenylation specificity factor (CPSF) recognizes the highly conserved hexanucleotide AAUAAA, whereas CstF binds to GU- or U-rich elements downstream of the poly(A) site.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cleavage stimulation factor subunit 2;Cleavage stimulation factor subunit 1;Cleavage stimulation factor subunit 3	CSTF2;CSTF1;CSTF3	None;None;None
1147	Polyadenylation complex (CSTF1, CSTF2, CSTF3, SYMPK CPSF1, CPSF2, CPSF3)	Human	None	None	P33240;Q05048;Q10570;Q12996;Q92797;Q9P2I0;Q9UKF6	1478;1477;29894;1479;8189;53981;51692	MI:0019-coimmunoprecipitation	GO:0031124;GO:0003723;GO:0005634;GO:0006378	mRNA 3'-end processing;RNA binding;nucleus;mRNA polyadenylation	11.04.03.05;16.03.03;70.10	3'-end processing;RNA binding;nucleus	10669729	Polyadenylation of mRNA precursors is a two-step reaction requiring multiple protein factors. The polyadenylation complex (containing Cstf1, Cstf2, Cstf3, Sympk, Cpsf1, Cpsf2 and Cpsf3), which contains the cleavage stimulation factor (CstF) and subunits of the cleavage and polyadenylation specificity factor (CPSF) might consist of more protein components.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cleavage stimulation factor subunit 2;Cleavage stimulation factor subunit 1;Cleavage and polyadenylation specificity factor subunit 1;Cleavage stimulation factor subunit 3;Symplekin;Cleavage and polyadenylation specificity factor subunit 2;Cleavage and polyadenylation specificity factor subunit 3	CSTF2;CSTF1;CPSF1;CSTF3;SYMPK;CPSF2;CPSF3	None;None;CPSF160;None;SPK;CPSF100, KIAA1367;CPSF73
1148	snRNP-free U1A (SF-A) complex	Human	None	None	P09012;P17844;P23246;Q15233	6626;1655;6421;4841	MI:0096-pull down	GO:0031123;GO:0031124;GO:0003723;GO:0005634	RNA 3'-end processing;mRNA 3'-end processing;RNA binding;nucleus	11.04.03.05;16.03.03;70.10	3'-end processing;RNA binding;nucleus	16373496	The formation of mRNAs in the nuclei of eukaryotic cells involves several co- and post-transcriptional processing events, including 5' end capping, RNA splicing, and 3' end formation. The SF-A complex was found to be involved in cleavage of the mRNA precursor, an essential step of the 3' end formation process.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	U1 small nuclear ribonucleoprotein A;Probable ATP-dependent RNA helicase DDX5;Splicing factor, proline- and glutamine-rich;Non-POU domain-containing octamer-binding protein	SNRPA;DDX5;SFPQ;NONO	None;G17P1 HELR HLR1;PSF;NRB54
1149	Histone H3.1 complex	Human	None	None	O14929;P49321;P62805;P68431;Q09028;Q13111;Q13112;Q8TEX9;Q9NVP2;Q9Y294	8520;4678;None;None;5928;10036;8208;79711;55723;25842	MI:0019-coimmunoprecipitation	GO:0005634;GO:0065003	nucleus;protein-containing complex assembly	70.10	nucleus	14718166	The H3.1 and H3.3 complexes contain distinct histone chaperones, CAF-1 and HIRA, that were shown to be necessary to mediate DNA-synthesis-dependent and -independent nucleosome assembly, respectively.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone acetyltransferase type B catalytic subunit;Nuclear autoantigenic sperm protein;Histone H4;Histone H3.1;Histone-binding protein RBBP4;Chromatin assembly factor 1 subunit A;Chromatin assembly factor 1 subunit B;Importin-4;Histone chaperone ASF1B;Histone chaperone ASF1A	HAT1;NASP;H4C1;H3C1;RBBP4;CHAF1A;CHAF1B;IPO4;ASF1B;ASF1A	KAT1;None;H4/A H4FA HIST1H4A;H3FA,HIST1H3A;RBAP48;CAF CAF1P150;CAF1A CAF1P60 MPHOSPH7 MPP7;IMP4B, RANBP4;None;None
1150	Histone H3.3 complex	Human	None	None	O14929;P49321;P54198;P62805;P84243;Q09028;Q8TEX9;Q9NVP2;Q9Y294	8520;4678;7290;None;None;5928;79711;55723;25842	MI:0019-coimmunoprecipitation	GO:0005634;GO:0065003	nucleus;protein-containing complex assembly	70.10	nucleus	14718166	The H3.1 and H3.3 complexes contain distinct histone chaperones, CAF-1 and HIRA, that were shown to be necessary to mediate DNA-synthesis-dependent and -independent nucleosome assembly, respectively.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone acetyltransferase type B catalytic subunit;Nuclear autoantigenic sperm protein;Protein HIRA;Histone H4;Histone H3.3;Histone-binding protein RBBP4;Importin-4;Histone chaperone ASF1B;Histone chaperone ASF1A	HAT1;NASP;HIRA;H4C1;H3-3A;RBBP4;IPO4;ASF1B;ASF1A	KAT1;None;DGCR1 HIR TUPLE1;H4/A H4FA HIST1H4A;H3.3A H3F3 H3F3A;RBAP48;IMP4B, RANBP4;None;None
1152	FA complex (Fanconi anemia complex)	Human	None	None	O15287;O15360;Q00597;Q8IYD8;Q8NB91;Q9HB96;Q9NPI8;Q9NW38	2189;2175;2176;57697;2187;2178;2188;55120	MI:0019-coimmunoprecipitation	GO:0016567;GO:0006974;GO:0005634	protein ubiquitination;cellular response to DNA damage stimulus;nucleus	14.07.05;32.01.09;70.10	modification by ubiquitination, deubiquitination;DNA damage response;nucleus	16116422	The Fanconi complex normally promotes a cascade of changes in a biochemical pathway that ultimately leads to the repair of cellular DNA damage. But if any of the proteins within the complex are mutated, the enzyme FancL is disabled and the DNA repair pathway is disrupted.	FA complex is involved in Fanconi anemia (FA) disease.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Fanconi anemia group G protein;Fanconi anemia group A protein;Fanconi anemia group C protein;Fanconi anemia group M protein;Fanconi anemia group B protein;Fanconi anemia group E protein;Fanconi anemia group F protein;E3 ubiquitin-protein ligase FANCL	FANCG;FANCA;FANCC;FANCM;FANCB;FANCE;FANCF;FANCL	XRCC9;FAA FACA FANCH;FAC FACC;KIAA1596;None;FACE;None;PHF9
1153	Integrator complex	Human	None	None	Q5TA45;Q68E01;Q6P9B9;Q75QN2;Q8N201;Q96CB8;Q96HW7;Q9H0H0;Q9NV88;Q9NVH2;Q9NVR2;Q9UL03	54973;65123;80789;55656;26173;57117;92105;57508;55756;25896;55174;26512	MI:0019-coimmunoprecipitation;MI:0071-molecular sieving	GO:0006396;GO:0005634	RNA processing;nucleus	11.04;70.10	RNA processing;nucleus	16239144	The Intergrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3' box-dependent processing. The Integrator complex is recruited to the U1 and U2 snRNA genes and mediates the snRNAs 3' cleavage.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrator complex subunit 11;Integrator complex subunit 3;Integrator complex subunit 5;Integrator complex subunit 8;Integrator complex subunit 1;Integrator complex subunit 12;Integrator complex subunit 4;Integrator complex subunit 2;Integrator complex subunit 9;Integrator complex subunit 7;Integrator complex subunit 10;Integrator complex subunit 6	INTS11;INTS3;INTS5;INTS8;INTS1;INTS12;INTS4;INTS2;INTS9;INTS7;INTS10;INTS6	CPSF3L RC68;C1orf193 C1orf60;KIAA1698;C8orf52;KIAA1440;PHF22;None;KIAA1287;RC74;C1orf73;C8orf35;DBI1 DDX26 DDX26A
1154	DSS1 complex	Human	None	None	A6NKF1;P51587;P60896;Q5TA45;Q6P9B9;Q75QN2;Q96HW7;Q96PV6;Q9H0H0;Q9NV88;Q9NVH2;Q9NVR2;Q9UL03	None;675;7979;54973;80789;55656;92105;114823;57508;55756;25896;55174;26512	MI:0019-coimmunoprecipitation;MI:0071-molecular sieving	GO:0005634	nucleus	70.10	nucleus	16239144	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	SAC3 domain-containing protein 1;Breast cancer type 2 susceptibility protein;26S proteasome complex subunit SEM1;Integrator complex subunit 11;Integrator complex subunit 5;Integrator complex subunit 8;Integrator complex subunit 4;Leukocyte receptor cluster member 8;Integrator complex subunit 2;Integrator complex subunit 9;Integrator complex subunit 7;Integrator complex subunit 10;Integrator complex subunit 6	SAC3D1;BRCA2;SEM1;INTS11;INTS5;INTS8;INTS4;LENG8;INTS2;INTS9;INTS7;INTS10;INTS6	SHD1;FACD FANCD1;C7orf76 DSS1 SHFDG1 SHFM1;CPSF3L RC68;KIAA1698;C8orf52;None;KIAA1932;KIAA1287;RC74;C1orf73;C8orf35;DBI1 DDX26 DDX26A
1155	Integrator-RNAPII complex	Human	None	None	P24928;P30876;Q5TA45;Q68E01;Q6P9B9;Q75QN2;Q8N201;Q96CB8;Q96HW7;Q9H0H0;Q9NV88;Q9NVH2;Q9NVR2;Q9UL03	5430;5431;54973;65123;80789;55656;26173;57117;92105;57508;55756;25896;55174;26512	MI:0019-coimmunoprecipitation;MI:0071-molecular sieving	GO:0006351;GO:0006396;GO:0005634	DNA-templated transcription;RNA processing;nucleus	11;11.04;70.10	TRANSCRIPTION;RNA processing;nucleus	16239144	The integrator complex interacts with the C-terminal domain of the RNA Polymerase II. The integrator-RNAPII complex mediates RNAPII-dependent transcription of at least U1 and U2 snRNA genes.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA-directed RNA polymerase II subunit RPB1;DNA-directed RNA polymerase II subunit RPB2;Integrator complex subunit 11;Integrator complex subunit 3;Integrator complex subunit 5;Integrator complex subunit 8;Integrator complex subunit 1;Integrator complex subunit 12;Integrator complex subunit 4;Integrator complex subunit 2;Integrator complex subunit 9;Integrator complex subunit 7;Integrator complex subunit 10;Integrator complex subunit 6	POLR2A;POLR2B;INTS11;INTS3;INTS5;INTS8;INTS1;INTS12;INTS4;INTS2;INTS9;INTS7;INTS10;INTS6	POLR2;None;CPSF3L RC68;C1orf193 C1orf60;KIAA1698;C8orf52;KIAA1440;PHF22;None;KIAA1287;RC74;C1orf73;C8orf35;DBI1 DDX26 DDX26A
1158	p33ING1b-p300 complex	Human	None	None	Q09472;Q9UK53	2033;3621	MI:0006-anti bait coimmunoprecipitation	GO:0006265;GO:0000278;GO:0051726;GO:0006473;GO:0051276;GO:0005694	DNA topological change;mitotic cell cycle;regulation of cell cycle;protein acetylation;chromosome organization;chromosome	10.01.09.05;10.03.01.01;10.03.01;14.07.04;42.10.03;70.10.03	DNA conformation modification (e.g. chromatin);mitotic cell cycle;mitotic cell cycle and cell cycle control;modification by acetylation, deacetylation;organization of chromosome structure;chromosome	12015309	Anti-p300 immunoprecipitates contained p33ING1b, but not p47ING1a.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Histone acetyltransferase p300;Inhibitor of growth protein 1	EP300;ING1	P300;None
1159	p33ING1b-HDAC1 complex	Human	None	None	Q13547;Q9UK53	3065;3621	MI:0006-anti bait coimmunoprecipitation	GO:0006265;GO:0000278;GO:0051726;GO:0006476;GO:0051276;GO:0005694	DNA topological change;mitotic cell cycle;regulation of cell cycle;protein deacetylation;chromosome organization;chromosome	10.01.09.05;10.03.01.01;10.03.01;14.07.04;42.10.03;70.10.03	DNA conformation modification (e.g. chromatin);mitotic cell cycle;mitotic cell cycle and cell cycle control;modification by acetylation, deacetylation;organization of chromosome structure;chromosome	12015309	HDAC1 interacts as well with p33ING1b as with p47ING1a.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Histone deacetylase 1;Inhibitor of growth protein 1	HDAC1;ING1	RPD3L1;None
1160	ING1-p300-PCNA complex	Human	None	None	P12004;Q09472;Q9UK53	5111;2033;3621	MI:0006-anti bait coimmunoprecipitation	GO:0006281;GO:0006265;GO:0000278;GO:0051726;GO:0006473;GO:0051276;GO:0005694	DNA repair;DNA topological change;mitotic cell cycle;regulation of cell cycle;protein acetylation;chromosome organization;chromosome	10.01.05.01;10.01.09.05;10.03.01.01;10.03.01;14.07.04;42.10.03;70.10.03	DNA repair;DNA conformation modification (e.g. chromatin);mitotic cell cycle;mitotic cell cycle and cell cycle control;modification by acetylation, deacetylation;organization of chromosome structure;chromosome	12015309	p33ING1b affects the degree of physical association between proliferating cell nuclear antigen (PCNA) and p300.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Proliferating cell nuclear antigen;Histone acetyltransferase p300;Inhibitor of growth protein 1	PCNA;EP300;ING1	None;P300;None
1162	Ubiquitin E3 ligase (DDB1, DDB2, CUL4A, CUL4B, RBX1)	Human	None	None	P62877;Q13619;Q13620;Q16531;Q92466	9978;8451;8450;1642;1643	MI:0071-molecular sieving;MI:0226-ion exchange chromatography	GO:0016567;GO:0006974;GO:0009314;GO:0006511;GO:0000786	protein ubiquitination;cellular response to DNA damage stimulus;response to radiation;ubiquitin-dependent protein catabolic process;nucleosome	14.07.05;32.01.09;32.01.13;14.13.01.01	modification by ubiquitination, deubiquitination;DNA damage response;electromagnetic waves stress response (e.g. UV, X-ray);proteasomal degradation (ubiquitin/proteasomal pathway)	16678110	Ubiquitin E3 ligases covalently attach ubiquitin to a lysine residue on a target protein. Polyubiquitination marks proteins for degradation by the proteasome. The CUL4-DDB-ROC1 complex is a ubiquitin E3 ligase for histones H3 and H4. CUL4-DDB-ROC1-mediated H3 and H4 ubiquitylation was shown to facilitate cellular response to UV damage by affecting nucleosome stability.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase RBX1;Cullin-4A;Cullin-4B;DNA damage-binding protein 1;DNA damage-binding protein 2	RBX1;CUL4A;CUL4B;DDB1;DDB2	RNF75 ROC1;None;KIAA0695;XAP1;None
1163	ING1-PCNA complex	Human	None	None	P12004;Q9UK53	5111;3621	MI:0006-anti bait coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0006974;GO:0009314;GO:0008219;GO:0005694	cellular response to DNA damage stimulus;response to radiation;cell death;chromosome	32.01.09;32.01.13;40.10;70.10.03	DNA damage response;electromagnetic waves stress response (e.g. UV, X-ray);cell death;chromosome	11682605	UV rapidly induces p33ING1b, but not p47ING1a isoform, to bind PCNA.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Proliferating cell nuclear antigen;Inhibitor of growth protein 1	PCNA;ING1	None;None
1165	RNF20-RNF40-UbE2E1 complex	Human	RNF20/40 complex; Ubiquitin E3 ligase	None	O75150;P51965;Q5VTR2	9810;7324;56254	MI:0096-pull down	GO:2001141;GO:0006355;GO:0016567;GO:0005634;GO:0006511	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;protein ubiquitination;nucleus;ubiquitin-dependent protein catabolic process	11.02.03.04;14.07.05;70.10;14.13.01.01	transcriptional control;modification by ubiquitination, deubiquitination;nucleus;proteasomal degradation (ubiquitin/proteasomal pathway)	16307923	In humans, the 600 kDa RNF20/40 complex is the E3 ligase and UbcH6 is the ubiquitin E2-conjugating enzyme for H2B-Lys120 monoubiquitination.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase BRE1B;Ubiquitin-conjugating enzyme E2 E1;E3 ubiquitin-protein ligase BRE1A	RNF40;UBE2E1;RNF20	BRE1B KIAA0661;UBCH6;BRE1A
1166	p400-associated complex	Human	None	None	O96019;P60709;Q96L91;Q9Y230;Q9Y265;Q9Y4A5	86;60;57634;10856;8607;8295	MI:0004-affinity chromatography technology	GO:0051276;GO:0006265;GO:0005515;GO:0005634	chromosome organization;DNA topological change;protein binding;nucleus	42.10.03;10.01.09.05;16.01;70.10	organization of chromosome structure;DNA conformation modification (e.g. chromatin);protein binding;nucleus	11509179	None	None	Since the authors did not specify ACTL6, we used ACTL6A.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Actin-like protein 6A;Actin, cytoplasmic 1;E1A-binding protein p400;RuvB-like 2;RuvB-like 1;Transformation/transcription domain-associated protein	ACTL6A;ACTB;EP400;RUVBL2;RUVBL1;TRRAP	BAF53 BAF53A INO80K;None;CAGH32 KIAA1498 KIAA1818 TNRC12;INO80J TIP48 TIP49B;INO80H NMP238 TIP49 TIP49A;PAF400
1167	Paf complex	Human	hPAF complex	None	Q6P1J9;Q6PD62;Q8N7H5;Q8WVC0;Q9GZS3	79577;9646;54623;123169;80349	MI:0096-pull down	GO:0006351;GO:0005634	DNA-templated transcription;nucleus	11;70.10	TRANSCRIPTION;nucleus	16307923	hPAF participates in histone H2B monoubiquitiation. In addition, hPAF coordinates events during transcription (initiation, promoter clearance, and elongation) and also events in RNA quality control. The hPAF complex interacts with the hSKI complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Parafibromin;RNA polymerase-associated protein CTR9 homolog;RNA polymerase II-associated factor 1 homolog;RNA polymerase-associated protein LEO1;WD repeat-containing protein 61	CDC73;CTR9;PAF1;LEO1;WDR61	C1orf28 HRPT2;KIAA0155 SH2BP1;PD2;RDL;None
1168	SKI complex	Human	hSKI complex	None	Q15477;Q6PGP7;Q9GZS3	6499;9652;80349	MI:0019-coimmunoprecipitation;MI:0071-molecular sieving	GO:2001141;GO:0006355;GO:0005737;GO:0005634;GO:0043488	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;cytoplasm;nucleus;regulation of mRNA stability	11.02.03.04;70.03;70.10;11.04.03.11	transcriptional control;cytoplasm;nucleus;control of mRNA stability	16024656	hSKI complex is present at transcriptionally active genes with recruitment dependent on hPAF complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Helicase SKI2W;Tetratricopeptide repeat protein 37;WD repeat-containing protein 61	SKIV2L;TTC37;WDR61	DDX13 SKI2W SKIV2 W;KIAA0372;None
1169	SNARE complex (SNAP23, STX4, VAMP3)	Human	None	platelet	O00161;Q12846;Q15836	8773;6810;9341	MI:0019-coimmunoprecipitation;MI:0047-far western blotting	GO:0006906;GO:0048489;GO:0016079;GO:0031201;GO:0061025	vesicle fusion;synaptic vesicle transport;synaptic vesicle exocytosis;SNARE complex;membrane fusion	20.09.07.27;20.09.16.09.05	vesicle fusion;synaptic vesicle exocytosis	12130530	SNARE (N-ethylmaleimide-sensitive factor attachment protein receptor) complexes are responsible for membrane fusion in the secretory pathway. VAMP-3 and VAMP-8 form ternary SNARE complexes with platelet syntaxin 4 and are required for platelet granule secretion.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Synaptosomal-associated protein 23;Syntaxin-4;Vesicle-associated membrane protein 3	SNAP23;STX4;VAMP3	None;STX4A;SYB3
1171	c-MYC-ATPase-helicase complex	Human	None	HeLa cells	O96019;P01106;Q9Y230;Q9Y265;Q9Y4A5	86;4609;10856;8607;8295	MI:0006-anti bait coimmunoprecipitation	GO:0051276;GO:0006355;GO:0006473;GO:0003677;GO:0005634	chromosome organization;regulation of DNA-templated transcription;protein acetylation;DNA binding;nucleus	42.10.03;11.02.03.04;14.07.04;16.03.01;70.10	organization of chromosome structure;transcriptional control;modification by acetylation, deacetylation;DNA binding;nucleus	11839798	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Actin-like protein 6A;Myc proto-oncogene protein;RuvB-like 2;RuvB-like 1;Transformation/transcription domain-associated protein	ACTL6A;MYC;RUVBL2;RUVBL1;TRRAP	BAF53 BAF53A INO80K;BHLHE39;INO80J TIP48 TIP49B;INO80H NMP238 TIP49 TIP49A;PAF400
1172	CBC complex (cap binding complex)	Human	None	in vitro	P52298;Q09161	22916;4686	MI:0413-electrophoretic mobility shift assay	GO:0003723;GO:0050658;GO:0051033;GO:0051169;GO:0005634	RNA binding;RNA transport;RNA transmembrane transporter activity;nuclear transport;nucleus	16.03.03;20.01.21;20.09.01;70.10	RNA binding;RNA transport;nuclear transport;nucleus	10786834	The heterodimeric nuclear cap binding complex (CBC) binds to 5'-capped polymerase II transcripts. It enhances the efficiency of several mRNA maturation steps and is essential for U snRNA nuclear export in multicellular eukaryotes.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Nuclear cap-binding protein subunit 2;Nuclear cap-binding protein subunit 1	NCBP2;NCBP1	CBP20;CBP80 NCBP
1173	TIP49-TIP48-BAF53 complex	Human	None	None	O96019;Q9Y230;Q9Y265	86;10856;8607	MI:0007-anti tag coimmunoprecipitation	GO:0051276;GO:0005634	chromosome organization;nucleus	42.10.03;70.10	organization of chromosome structure;nucleus	11839798	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Actin-like protein 6A;RuvB-like 2;RuvB-like 1	ACTL6A;RUVBL2;RUVBL1	BAF53 BAF53A INO80K;INO80J TIP48 TIP49B;INO80H NMP238 TIP49 TIP49A
1174	PHAX-CBC complex (cap binding complex)	Human	None	None	P52298;Q09161;Q9H814	22916;4686;51808	MI:0413-electrophoretic mobility shift assay	GO:0003723;GO:0050658;GO:0051033;GO:0051169;GO:0005737;GO:0005634	RNA binding;RNA transport;RNA transmembrane transporter activity;nuclear transport;cytoplasm;nucleus	16.03.03;20.01.21;20.09.01;70.03;70.10	RNA binding;RNA transport;nuclear transport;cytoplasm;nucleus	10786834	In metazoa, assembly of spliceosomal U snRNPs requires nuclear export of U snRNA precursors. Export depends upon the RNA cap structure, nuclear cap-binding complex (CBC), the export receptor CRM1/Xpo1, and RanGTP. PHAX (phosphorylated adaptor for RNA export) is an additional factor required for U snRNA export complex assembly in vitro. In vivo, PHAX is required for U snRNA export but not for CRM1-mediated export in general. PHAX is phosphorylated in the nucleus and then exported with RNA to the cytoplasm, where it is dephosphorylated. PHAX phosphorylation is essential for export complex assembly while its dephosphorylation causes export complex disassembly. The compartmentalized PHAX phosphorylation cycle can contribute to the directionality of export. PHAX binding to CBC is greatly increased by the presence of capped RNA.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Nuclear cap-binding protein subunit 2;Nuclear cap-binding protein subunit 1;Phosphorylated adapter RNA export protein	NCBP2;NCBP1;PHAX	CBP20;CBP80 NCBP;RNUXA
1175	TRRAP-BAF53-HAT complex	Human	None	None	O96019;Q9Y4A5	86;8295	MI:0007-anti tag coimmunoprecipitation	GO:0006265;GO:2001141;GO:0006355;GO:0006473;GO:0051276;GO:0005634	DNA topological change;regulation of RNA biosynthetic process;regulation of DNA-templated transcription;protein acetylation;chromosome organization;nucleus	10.01.09.05;11.02.03.04;14.07.04;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcriptional control;modification by acetylation, deacetylation;organization of chromosome structure;nucleus	11839798	TRRAP and BAF53 associate with an up to now not identified histone acetyltransferase activity which does not contain TIP60, TIP49 or TIP48.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Actin-like protein 6A;Transformation/transcription domain-associated protein	ACTL6A;TRRAP	BAF53 BAF53A INO80K;PAF400
1176	NCBP1-NCBP2-PHAX-RAN-XPO1 complex	Human	CRM1-RAN-PHAX-CBC complex (cap binding complex)	None	O14980;P52298;P62826;Q09161;Q9H814	7514;22916;5901;4686;51808	MI:0413-electrophoretic mobility shift assay;MI:0430-nucleic acid uv cross-linking assay	GO:0005737;GO:0005634;GO:0051168;GO:0050658	cytoplasm;nucleus;nuclear export;RNA transport	70.03;70.10;20.01.21	cytoplasm;nucleus;RNA transport	10786834	In metazoa, assembly of spliceosomal U snRNPs requires nuclear export of U snRNA precursors. Export depends upon the RNA cap structure, nuclear cap-binding complex (CBC), the export receptor CRM1/Xpo1, and RanGTP. PHAX (phosphorylated adaptor for RNA export) is an additional factor required for U snRNA export complex assembly in vitro. PHAX binding to CBC is greatly increased by the presence of capped RNA. Phosphorylated PHAX can bind to RanGTP/Xpo1 but does so more strongly in the presence of CBC and even more in the presence of both CBC and RNA. Thus, every step in U snRNA export complex formation involves some degree of cooperativity.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Exportin-1;Nuclear cap-binding protein subunit 2;GTP-binding nuclear protein Ran;Nuclear cap-binding protein subunit 1;Phosphorylated adapter RNA export protein	XPO1;NCBP2;RAN;NCBP1;PHAX	CRM1;CBP20;ARA24;CBP80 NCBP;RNUXA
1177	Polycomb repressive complex 4	Human	PRC4 complex	None	O75530;Q15910;Q96EB6	8726;2146;23411	MI:0071-molecular sieving;MI:0226-ion exchange chromatography	GO:0006265;GO:0051276;GO:0005634;GO:0045892	DNA topological change;chromosome organization;nucleus;negative regulation of DNA-templated transcription	10.01.09.05;42.10.03;70.10;11.02.03.04.03	DNA conformation modification (e.g. chromatin);organization of chromosome structure;nucleus;transcription repression	15684044	Polycomb repressive complexes are required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. They are methylating histones at lysine residues. PRC4 methylates preferentially the histone H1b isoform, whereas PRC2 methylated preferentially the histone H1d isoform. The PRC3 complex exclusively targets methylation of histone H3-K27, and the activity is repressed in the presence of histone H1. PRC2 also methylates histone H3-K27 but in the presence of histone H1, PRC2 methylates both H3-K27 and H1-K26.	PRC complexes are overexpressed in breast, colon, and prostate cancers.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Polycomb protein EED;Histone-lysine N-methyltransferase EZH2;NAD-dependent protein deacetylase sirtuin-1	EED;EZH2;SIRT1	None;KMT6;SIR2L1
1178	BCOR complex	Human	Ubiquitin E3 ligase	None	P11142;P63208;Q06587;Q6W2J9;Q8N488;Q8NHM5;Q99496;Q9BSM1	3312;6500;6015;54880;23429;84678;6045;84759	MI:0019-coimmunoprecipitation	GO:0016567;GO:0005634;GO:0006511;GO:0006351;GO:0016577	protein ubiquitination;nucleus;ubiquitin-dependent protein catabolic process;DNA-templated transcription;histone demethylation	14.07.05;70.10;14.13.01.01;11	modification by ubiquitination, deubiquitination;nucleus;proteasomal degradation (ubiquitin/proteasomal pathway);TRANSCRIPTION	16943429	Ubiquitin E3 ligases covalently attach ubiquitin to a lysine residue on a target protein. Polyubiquitination marks proteins for degradation by the proteasome. The BCOR complex contains E3 ligase activity for histone H2A. Monoubiquitylated H2A is present together with the BCOR complex at BCL6 target genes in B cells. This strongly suggests a role of BCOR as regulator of BCL6, a sequence-specific transcriptional repressor, that probably plays an important role in lymphomagenesis.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Heat shock cognate 71 kDa protein;S-phase kinase-associated protein 1;E3 ubiquitin-protein ligase RING1;BCL-6 corepressor;RING1 and YY1-binding protein;Lysine-specific demethylase 2B;E3 ubiquitin-protein ligase RING2;Polycomb group RING finger protein 1	HSPA8;SKP1;RING1;BCOR;RYBP;KDM2B;RNF2;PCGF1	HSC70 HSP73 HSPA10;EMC19 OCP2 SKP1A TCEB1L;RNF1;KIAA1575;DEDAF YEAF1;CXXC2 FBL10 FBXL10 JHDM1B NDY1 PCCX2;BAP1 DING HIPI3 RING1B;NSPC1 RNF68
1179	CENP-A NAC-CAD complex	Human	CENP-A-nucleosome distal (CAD) centromere complex	HeLa cells	P07199;Q03188;Q13352;Q6IPU0;Q71F23;Q7L2Z9;Q8N0S6;Q8N2Z9;Q96BT3;Q96H22;Q9BS16;Q9BU64;Q9H3R5;Q9NSP4	1059;1060;23421;401541;79682;55166;91687;None;80152;55839;64105;79172;64946;79019	MI:0676-tandem affinity purification	GO:0007093;GO:0007098;GO:0007059;GO:0000775;GO:0051382;GO:0006349;GO:0051225	mitotic cell cycle checkpoint signaling;centrosome cycle;chromosome segregation;chromosome, centromeric region;kinetochore assembly;regulation of gene expression by genomic imprinting;spindle assembly	10.03.05.01;10.03.04.05;70.10.04;10.03.04.01;10.01.09.07	spindle pole body/centrosome and microtubule cycle;chromosome segregation/division;centromere / kinetochore;centromere/kinetochore complex maturation;DNA imprinting and other epigenetic effects	16622419	Assembly of CENP-A NAC complex at centromeres is dependent on CENP-M, CENP-N and CENP-T.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Major centromere autoantigen B;Centromere protein C;Centromere protein R;Centromere protein P;Centromere protein U;Centromere protein Q;Centromere protein L;Centromere protein S;Centromere protein T;Centromere protein N;Centromere protein K;Centromere protein O;Centromere protein H;Centromere protein M	CENPB;CENPC;ITGB3BP;CENPP;CENPU;CENPQ;CENPL;CENPS;CENPT;CENPN;CENPK;CENPO;CENPH;CENPM	None;CENPC1 ICEN7;CENPR NRIF3;None;ICEN24 KLIP1 MLF1IP PBIP1;C6orf139;C1orf155 ICEN33;APITD1 FAAP16 MHF1;C16orf56, ICEN22;C16orf60 ICEN32;ICEN37;ICEN36 MCM21R;ICEN35;C22orf18 ICEN39 PANE1
1181	C complex spliceosome	Human	None	None	O43290;O43390;O43660;O60306;O60506;O60508;O75533;O75643;O94906;O95391;O95926;P07910;P08579;P09651;P09661;P11940;P14678;P17844;P22626;P31943;P38159;P38919;P42285;P51991;P52272;P52597;P61326;P61978;P62304;P62306;P62308;P62310;P62314;P62316;P62318;Q00839;Q01081;Q07955;Q12874;Q13435;Q13523;Q13573;Q14331;Q14562;Q15029;Q15393;Q15428;Q15459;Q6NZY4;Q6P2Q9;Q6UX04;Q86V81;Q8IYB3;Q8WUQ7;Q92620;Q96BP3;Q96DF8;Q96DI7;Q99459;Q9BRR8;Q9BRX9;Q9BUQ8;Q9BZJ0;Q9H2H8;Q9H307;Q9H5Z1;Q9HCG8;Q9HCS7;Q9NW64;Q9P013;Q9UBB9;Q9UJV9;Q9UKM9;Q9ULR0;Q9UMS4;Q9UNP9;Q9UQ35;Q9Y333;Q9Y3C6;Q9Y5S9	9092;10236;5356;9716;10492;51362;23451;23020;24148;10569;25949;3183;6629;3178;6627;26986;6628;1655;3181;3187;27316;9775;23517;220988;4670;3185;4116;3190;6635;6636;6637;27258;6632;6633;6634;3192;7307;6426;10946;10992;8899;22938;2483;1659;9343;23450;8175;10291;55596;10594;10283;10189;10250;58509;9785;23398;8220;9410;988;55094;84292;9416;51340;53938;5411;60625;57703;56949;55696;51503;None;51428;22913;57461;27339;10450;23524;57819;51645;9939	MI:0028-cosedimentation in solution;MI:0096-pull down	GO:0000398;GO:0005681	mRNA splicing, via spliceosome;spliceosomal complex	11.04.03	mRNA processing (splicing, 5'-, 3'-end processing)	11991638	In eukaryotes, the removal of introns from nascent transcripts is mediated by a highly dynamic, macromolecular machine called the spliceosome.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	U4/U6.U5 tri-snRNP-associated protein 1;Heterogeneous nuclear ribonucleoprotein R;Pleiotropic regulator 1;RNA helicase aquarius;Heterogeneous nuclear ribonucleoprotein Q;Pre-mRNA-processing factor 17;Splicing factor 3B subunit 1;U5 small nuclear ribonucleoprotein 200 kDa helicase;Pre-mRNA-processing factor 6;Pre-mRNA-splicing factor SLU7;Pre-mRNA-splicing factor SYF2;Heterogeneous nuclear ribonucleoproteins C1/C2;U2 small nuclear ribonucleoprotein B'';Heterogeneous nuclear ribonucleoprotein A1;U2 small nuclear ribonucleoprotein A';Polyadenylate-binding protein 1;Small nuclear ribonucleoprotein-associated proteins B and B';Probable ATP-dependent RNA helicase DDX5;Heterogeneous nuclear ribonucleoproteins A2/B1;Heterogeneous nuclear ribonucleoprotein H;RNA-binding motif protein, X chromosome;Eukaryotic initiation factor 4A-III;Exosome RNA helicase MTR4;Heterogeneous nuclear ribonucleoprotein A3;Heterogeneous nuclear ribonucleoprotein M;Heterogeneous nuclear ribonucleoprotein F;Protein mago nashi homolog;Heterogeneous nuclear ribonucleoprotein K;Small nuclear ribonucleoprotein E;Small nuclear ribonucleoprotein F;Small nuclear ribonucleoprotein G;U6 snRNA-associated Sm-like protein LSm3;Small nuclear ribonucleoprotein Sm D1;Small nuclear ribonucleoprotein Sm D2;Small nuclear ribonucleoprotein Sm D3;Heterogeneous nuclear ribonucleoprotein U;Splicing factor U2AF 35 kDa subunit;Serine/arginine-rich splicing factor 1;Splicing factor 3A subunit 3;Splicing factor 3B subunit 2;Serine/threonine-protein kinase PRP4 homolog;SNW domain-containing protein 1;Protein FRG1;ATP-dependent RNA helicase DHX8;116 kDa U5 small nuclear ribonucleoprotein component;Splicing factor 3B subunit 3;Splicing factor 3A subunit 2;Splicing factor 3A subunit 1;Zinc finger CCHC domain-containing protein 8;Pre-mRNA-processing-splicing factor 8;Spliceosome-associated protein CWC27 homolog;THO complex subunit 4;Serine/arginine repetitive matrix protein 1;Cactin;Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16;Peptidylprolyl isomerase domain and WD repeat-containing protein 1;Splicing factor ESS-2 homolog;U5 small nuclear ribonucleoprotein 40 kDa protein;Cell division cycle 5-like protein;G patch domain-containing protein 1;WD repeat domain-containing protein 83;Probable ATP-dependent RNA helicase DDX23;Crooked neck-like protein 1;Peptidyl-prolyl cis-trans isomerase-like 3;Pinin;Probable ATP-dependent RNA helicase DHX35;Pre-mRNA-splicing factor CWC22 homolog;Pre-mRNA-splicing factor SYF1;Pre-mRNA-splicing factor RBM22;Spliceosome-associated protein CWC15 homolog;Tuftelin-interacting protein 11;Probable ATP-dependent RNA helicase DDX41;RNA-binding protein Raly;Pre-mRNA-splicing factor ISY1 homolog;Pre-mRNA-processing factor 19;Peptidyl-prolyl cis-trans isomerase E;Serine/arginine repetitive matrix protein 2;U6 snRNA-associated Sm-like protein LSm2;Peptidyl-prolyl cis-trans isomerase-like 1;RNA-binding protein 8A	SART1;HNRNPR;PLRG1;AQR;SYNCRIP;CDC40;SF3B1;SNRNP200;PRPF6;SLU7;SYF2;HNRNPC;SNRPB2;HNRNPA1;SNRPA1;PABPC1;SNRPB;DDX5;HNRNPA2B1;HNRNPH1;RBMX;EIF4A3;MTREX;HNRNPA3;HNRNPM;HNRNPF;MAGOH;HNRNPK;SNRPE;SNRPF;SNRPG;LSM3;SNRPD1;SNRPD2;SNRPD3;HNRNPU;U2AF1;SRSF1;SF3A3;SF3B2;PRPF4B;SNW1;FRG1;DHX8;EFTUD2;SF3B3;SF3A2;SF3A1;ZCCHC8;PRPF8;CWC27;ALYREF;SRRM1;CACTIN;DHX38;PPWD1;ESS2;SNRNP40;CDC5L;GPATCH1;WDR83;DDX23;CRNKL1;PPIL3;PNN;DHX35;CWC22;XAB2;RBM22;CWC15;TFIP11;DDX41;RALY;ISY1;PRPF19;PPIE;SRRM2;LSM2;PPIL1;RBM8A	None;HNRPR;None;KIAA0560;HNRPQ NSAP1;EHB3 PRP17 PRPF17;SAP155;ASCC3L1 HELIC2 KIAA0788;C20orf14;None;CBPIN GCIPIP;HNRPC;None;HNRPA1;None;PAB1 PABP PABP1 PABPC2;COD SNRPB1;G17P1 HELR HLR1;HNRPA2B1;HNRPH HNRPH1;HNRPG RBMXP1;DDX48, KIAA0111;DOB1 KIAA0052 MTR4 SKIV2L2;HNRPA3;HNRPM NAGR1;HNRPF;MAGOHA;HNRPK;None;PBSCF;PBSCG;None;None;SNRPD1;None;C1orf199 HNRPU SAFA U21.1;U2AF35 U2AFBP;ASF SF2 SF2P33 SFRS1;SAP61;SAP145;KIAA0536 PRP4 PRP4H PRP4K;SKIIP SKIP;None;DDX8;KIAA0031 SNRP116;KIAA0017 SAP130;SAP62;SAP114;None;PRPC8;SDCCAG10;ALY BEF THOC4;SRM160;C19orf29;DDX38 KIAA0224 PRP16;KIAA0073;DGCR13 DGCR14 DGSH DGSI ES2;PRP8BP SFP38 WDR57;KIAA0432 PCDC5RP;ECGP GPATC1;MORG1;None;CRN;None;DRS MEMA;C20orf15 DDX35;KIAA1604 NCM;HCNP KIAA1177 SYF1;ZC3H16;C11orf5;STIP;ABS;HNRPCL2 P542;KIAA1160;NMP200 PRP19 SNEV;CYP33;KIAA0324 SRL300 SRM300;C6orf28 G7B;CYPL1;RBM8
1182	CDC5L core complex	Human	None	None	O43660;O75934;P11142;Q92616;Q99459;Q9UMS4	5356;10286;3312;10985;988;27339	MI:0019-coimmunoprecipitation;MI:0069-mass spectrometry studies of complexes	GO:0008380;GO:0003723;GO:0005634	RNA splicing;RNA binding;nucleus	11.04.03.01;16.03.03;70.10	splicing;RNA binding;nucleus	11101529	The CDC5L complex incorporates into the spliceosome in an ATP-dependent step. This complex is required for the second catalytic step of pre-mRNA splicing. Immunodepletion of the CDC5L complex from HeLa nuclear extract inhibits the formation of pre-mRNA splicing products in vitro but does not prevent spliceosome assembly. Experiments indicate that there exists a CDC5L core complex in HeLa nuclear extract containing at least six proteins that interact with each other and with other splicing factors and enzymes.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Pleiotropic regulator 1;Pre-mRNA-splicing factor SPF27;Heat shock cognate 71 kDa protein;eIF-2-alpha kinase activator GCN1;Cell division cycle 5-like protein;Pre-mRNA-processing factor 19	PLRG1;BCAS2;HSPA8;GCN1;CDC5L;PRPF19	None;DAM1;HSC70 HSP73 HSPA10;GCN1L1 KIAA0219;KIAA0432 PCDC5RP;NMP200 PRP19 SNEV
1183	CDC5L complex	Human	None	None	A8K8P3;O15297;O43660;O75533;O75934;P09012;P09661;P11142;P11388;P15884;P23246;P38159;P62136;P62314;P62316;P62318;P78527;Q01130;Q07955;Q12905;Q13435;Q14204;Q15427;Q7L1Q6;Q8IYB3;Q92616;Q99459;Q9P013;Q9UMS4;Q9UPN6	9814;8493;5356;23451;10286;6626;6627;3312;7153;6925;6421;27316;5499;6632;6633;6634;5591;6427;6426;3608;10992;1778;10262;9689;10250;10985;988;51503;27339;22828	MI:0019-coimmunoprecipitation;MI:0069-mass spectrometry studies of complexes	GO:0008380;GO:0003723;GO:0005634	RNA splicing;RNA binding;nucleus	11.04.03.01;16.03.03;70.10	splicing;RNA binding;nucleus	11101529	The CDC5L complex incorporates into the spliceosome in an ATP-dependent step. This complex is required for the second catalytic step of pre-mRNA splicing. Immunodepletion of the CDC5L complex from HeLa nuclear extract inhibits the formation of pre-mRNA splicing products in vitro but does not prevent spliceosome assembly.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein SFI1 homolog;Protein phosphatase 1D;Pleiotropic regulator 1;Splicing factor 3B subunit 1;Pre-mRNA-splicing factor SPF27;U1 small nuclear ribonucleoprotein A;U2 small nuclear ribonucleoprotein A';Heat shock cognate 71 kDa protein;DNA topoisomerase 2-alpha;Transcription factor 4;Splicing factor, proline- and glutamine-rich;RNA-binding motif protein, X chromosome;Serine/threonine-protein phosphatase PP1-alpha catalytic subunit;Small nuclear ribonucleoprotein Sm D1;Small nuclear ribonucleoprotein Sm D2;Small nuclear ribonucleoprotein Sm D3;DNA-dependent protein kinase catalytic subunit;Serine/arginine-rich splicing factor 2;Serine/arginine-rich splicing factor 1;Interleukin enhancer-binding factor 2;Splicing factor 3B subunit 2;Cytoplasmic dynein 1 heavy chain 1;Splicing factor 3B subunit 4;eIF5-mimic protein 2;Serine/arginine repetitive matrix protein 1;eIF-2-alpha kinase activator GCN1;Cell division cycle 5-like protein;Spliceosome-associated protein CWC15 homolog;Pre-mRNA-processing factor 19;SR-related and CTD-associated factor 8	SFI1;PPM1D;PLRG1;SF3B1;BCAS2;SNRPA;SNRPA1;HSPA8;TOP2A;TCF4;SFPQ;RBMX;PPP1CA;SNRPD1;SNRPD2;SNRPD3;PRKDC;SRSF2;SRSF1;ILF2;SF3B2;DYNC1H1;SF3B4;BZW1;SRRM1;GCN1;CDC5L;CWC15;PRPF19;SCAF8	KIAA0542;WIP1;None;SAP155;DAM1;None;None;HSC70 HSP73 HSPA10;TOP2;BHLHB19 ITF2 SEF2;PSF;HNRPG RBMXP1;PPP1A;None;SNRPD1;None;HYRC HYRC1;SFRS2;ASF SF2 SF2P33 SFRS1;NF45;SAP145;DHC1 DNCH1 DNCL DNECL DYHC KIAA0325;SAP49;5MP2 BZAP45 KIAA0005;SRM160;GCN1L1 KIAA0219;KIAA0432 PCDC5RP;C11orf5;NMP200 PRP19 SNEV;CCAP7 KIAA1116 RBM16
1185	EGFR-containing signaling complex	Human	None	None	O00443;O00750;P00533;P04626	5286;5287;1956;2064	MI:0019-coimmunoprecipitation	GO:0007173	epidermal growth factor receptor signaling pathway	30.05.01.12.01	EGF-receptor signalling pathway	10805725	EGF stimulation recruits both PI3K-C2alpha  and PI3K-C2beta  to the EGFR-containing signaling complex, together with ErbB-2.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha;Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta;Epidermal growth factor receptor;Receptor tyrosine-protein kinase erbB-2	PIK3C2A;PIK3C2B;EGFR;ERBB2	None;None;ERBB ERBB1 HER1;HER2 MLN19 NEU NGL
1186	ESCRT-III complex	Human	None	HEK293T cells	O43633;Q7LBR1;Q96CF2;Q96FZ7;Q9BY43;Q9H444;Q9HD42;Q9NZZ3;Q9UQN3;Q9Y3E7	27243;57132;92421;79643;29082;128866;5119;51510;25978;51652	MI:0007-anti tag coimmunoprecipitation	GO:0006886;GO:0006605;GO:0015031;GO:0016192;GO:0005737	intracellular protein transport;protein targeting;protein transport;vesicle-mediated transport;cytoplasm	14.04;20.01.10;20.09.07;70.03	protein targeting, sorting and translocation;protein transport;vesicular transport (Golgi network, etc.);cytoplasm	14519844	The ESCRT-III complex is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-III complex is probably involved in the concentration of MVB cargo. In the ESCRT-III complex, it probably serves as an acceptor for ESCRT-II complex on endosomal membranes. In case of infection, the HIV-1 virus takes advantage of the ESCRT-III complex for budding and exocytic cargos of viral proteins.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Charged multivesicular body protein 2a;Charged multivesicular body protein 1b;Charged multivesicular body protein 4c;Charged multivesicular body protein 6;Charged multivesicular body protein 4a;Charged multivesicular body protein 4b;Charged multivesicular body protein 1a;Charged multivesicular body protein 5;Charged multivesicular body protein 2b;Charged multivesicular body protein 3	CHMP2A;CHMP1B;CHMP4C;CHMP6;CHMP4A;CHMP4B;CHMP1A;CHMP5;CHMP2B;CHMP3	BC2 CHMP2;C18orf2;SHAX3;VPS20;C14orf123 SHAX2;C20orf178 SHAX1;CHMP1 KIAA0047 PCOLN3 PRSM1;C9orf83 SNF7DC2;None;CGI149 NEDF VPS24
1187	ESCRT-II complex	Human	None	HEK293T cells	Q86VN1;Q96H20;Q9BRG1	51028;11267;84313	MI:0007-anti tag coimmunoprecipitation	GO:0006886;GO:0006605;GO:0015031;GO:0016192;GO:0005737	intracellular protein transport;protein targeting;protein transport;vesicle-mediated transport;cytoplasm	14.04;20.01.10;20.09.07;70.03	protein targeting, sorting and translocation;protein transport;vesicular transport (Golgi network, etc.);cytoplasm	14519844	The ESCRT-II complex is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Vacuolar protein-sorting-associated protein 36;Vacuolar-sorting protein SNF8;Vacuolar protein-sorting-associated protein 25	VPS36;SNF8;VPS25	C13orf9 EAP45;EAP30;DERP9 EAP20
1189	DNA double-strand break end-joining complex	Human	None	None	O60934;P12956;P13010;P49917;P49959;Q13426;Q92878	4683;2547;7520;3981;4361;7518;10111	MI:0071-molecular sieving;MI:0091-chromatography technology	GO:0006281;GO:0003677;GO:0006974;GO:0005634	DNA repair;DNA binding;cellular response to DNA damage stimulus;nucleus	10.01.05.01;16.03.01;32.01.09;70.10	DNA repair;DNA binding;DNA damage response;nucleus	11809878	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Nibrin;X-ray repair cross-complementing protein 6;X-ray repair cross-complementing protein 5;DNA ligase 4;Double-strand break repair protein MRE11;DNA repair protein XRCC4;DNA repair protein RAD50	NBN;XRCC6;XRCC5;LIG4;MRE11;XRCC4;RAD50	NBS NBS1 P95;G22P1;G22P2;None;HNGS1 MRE11A;None;None
1190	NCBP-NIP1 complex	Human	None	None	Q09161;Q96P71	4686;63941	MI:0018-two hybrid	GO:0005634;GO:0000339	nucleus;RNA cap binding	70.10	nucleus	7478990	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Nuclear cap-binding protein subunit 1;N-terminal EF-hand calcium-binding protein 3	NCBP1;NECAB3	CBP80 NCBP;APBA2BP NIP1 SYTIP2 XB51
1191	RNA pol II containing coactivator complex Tat-SF	Human	None	None	O00267;O43719;P19338;P24928;P50750	6829;27336;4691;5430;1025	MI:0019-coimmunoprecipitation;MI:0071-molecular sieving	GO:2001141;GO:0006355;GO:0003677;GO:0005634	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;DNA binding;nucleus	11.02.03.04;16.03.01;70.10	transcriptional control;DNA binding;nucleus	10393184	All fractions with Tat stimulatory activity contained these components as well as CDK9.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transcription elongation factor SPT5;HIV Tat-specific factor 1;Nucleolin;DNA-directed RNA polymerase II subunit RPB1;Cyclin-dependent kinase 9	SUPT5H;HTATSF1;NCL;POLR2A;CDK9	SPT5, SPT5H;None;None;POLR2;CDC2L4 TAK
1192	ESCRT-I complex	Human	None	HEK293T cells	A5D8V6;Q99816;Q9UK41	55048;7251;51160	MI:0007-anti tag coimmunoprecipitation	GO:0006886;GO:0006605;GO:0015031;GO:0016192;GO:0005737;GO:0005783	intracellular protein transport;protein targeting;protein transport;vesicle-mediated transport;cytoplasm;endoplasmic reticulum	14.04;20.01.10;20.09.07;70.03;70.07	protein targeting, sorting and translocation;protein transport;vesicular transport (Golgi network, etc.);cytoplasm;endoplasmic reticulum	15509564	ESCRT-I is one of three defined protein complexes in the class E vacuolar protein sorting (VPS) pathway required for the sorting of ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Vacuolar protein sorting-associated protein 37C;Tumor susceptibility gene 101 protein;Vacuolar protein sorting-associated protein 28 homolog	VPS37C;TSG101;VPS28	PML39;None;None
1193	Rap1 complex	Human	None	None	P09874;P12956;P13010;P49959;Q15554;Q92878;Q9NYB0	142;2547;7520;4361;7014;10111;54386	MI:0007-anti tag coimmunoprecipitation	GO:0003677;GO:0006974;GO:0051276;GO:0005634	DNA binding;cellular response to DNA damage stimulus;chromosome organization;nucleus	16.03.01;32.01.09;42.10.03;70.10	DNA binding;DNA damage response;organization of chromosome structure;nucleus	15100233	This complex is responsible for proper maintenance of telomere length and structure. Rad50, Mre11 and Ku86 are recruited to Rap1 independent of TRF2. PARP1, however, most likely interacts with Rap1 through TRF2.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Poly [ADP-ribose] polymerase 1;X-ray repair cross-complementing protein 6;X-ray repair cross-complementing protein 5;Double-strand break repair protein MRE11;Telomeric repeat-binding factor 2;DNA repair protein RAD50;Telomeric repeat-binding factor 2-interacting protein 1	PARP1;XRCC6;XRCC5;MRE11;TERF2;RAD50;TERF2IP	ADPRT PPOL;G22P1;G22P2;HNGS1 MRE11A;TRBF2, TRF2;None;DRIP5, RAP1
1194	E2F-6 complex	Human	E2F6.com-1 complex	None	O75461;O75712;P61244;Q06587;Q14186;Q8IWI9;Q8IY57;Q969R5;Q96KQ7;Q99496;Q9BYE7;Q9H9B1	1876;2707;4149;6015;7027;23269;10138;83746;10919;6045;84108;79813	MI:0007-anti tag coimmunoprecipitation;MI:0069-mass spectrometry studies of complexes	GO:0045892;GO:0003677;GO:0005634;GO:0051567	negative regulation of DNA-templated transcription;DNA binding;nucleus;histone H3-K9 methylation	11.02.03.04.03;16.03.01;70.10	transcription repression;DNA binding;nucleus	12004135	The E2F-6 complex occupies target promoters like E2F binding elements and contains chromatin modifiers such as histone methyltransferases. Data suggest that these chromatin modifiers contribute to silencing of E2F- and Myc-responsive genes in quiescent cells.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transcription factor E2F6;Gap junction beta-3 protein;Protein max;E3 ubiquitin-protein ligase RING1;Transcription factor Dp-1;MAX gene-associated protein;YY1-associated factor 2;Lethal(3)malignant brain tumor-like protein 2;Histone-lysine N-methyltransferase EHMT2;E3 ubiquitin-protein ligase RING2;Polycomb group RING finger protein 6;Histone-lysine N-methyltransferase EHMT1	E2F6;GJB3;MAX;RING1;TFDP1;MGA;YAF2;L3MBTL2;EHMT2;RNF2;PCGF6;EHMT1	None;CX31;BHLHD4;RNF1;DP1;KIAA0518 MAD5;None;None;BAT8 C6orf30 G9A KMT1C NG36;BAP1 DING HIPI3 RING1B;MBLR RNF134;EUHMTASE1 GLP KIAA1876 KMT1D
1195	Exon junction complex (mRNA splicing-dependent)	Human	None	None	Q6P2Q9;Q8IYB3	10594;10250	MI:0019-coimmunoprecipitation;MI:0029-cosedimentation through density gradient;MI:0430-nucleic acid uv cross-linking assay	GO:0008380;GO:0003723;GO:0005634	RNA splicing;RNA binding;nucleus	11.04.03.01;16.03.03;70.10	splicing;RNA binding;nucleus	10809668	The results indicate that splicing alters the complement of proteins associated with exon-exon junctions regardless of the nature of the photoreactive group, the position of this group relative to the exon-exon junction, or the exact sequence of the 5' exon, even though changing the position or the nature of the photoreactive group can affect exactly which proteins are detected by this method.	None	At the time of annotation, the additional members p50 and p20 of the protein complex remained unidentified.	Homo sapiens (Human);Homo sapiens (Human)	Pre-mRNA-processing-splicing factor 8;Serine/arginine repetitive matrix protein 1	PRPF8;SRRM1	PRPC8;SRM160
1196	RAD51C-XRCC3 complex	Human	None	brain	O43502;O43542	5889;7517	MI:0004-affinity chromatography technology;MI:0018-two hybrid	GO:0006281;GO:0006310;GO:0003677;GO:0005524;GO:0006974;GO:0005634	DNA repair;DNA recombination;DNA binding;ATP binding;cellular response to DNA damage stimulus;nucleus	10.01.05.01;10.01.05.03;16.03.01;16.19.03;32.01.09;70.10	DNA repair;DNA recombination;DNA binding;ATP binding;DNA damage response;nucleus	11331762	Rad51C protein alone catalyzes homologous pairing, suggesting that Rad51C is the catalytic subunit of the complex. The DNA-binding activity of Rad51C-Xrcc3 complex drastically decreases in the absence of Xrcc3, indicating that Xrcc3 is important for the DNA binding activity of the complex.	None	None	Homo sapiens (Human);Homo sapiens (Human)	DNA repair protein RAD51 homolog 3;DNA repair protein XRCC3	RAD51C;XRCC3	RAD51L2;None
1198	TIN2 complex	Human	None	None	Q15554;Q96AP0;Q9BSI4;Q9NUX5	7014;65057;26277;25913	MI:0071-molecular sieving;MI:0226-ion exchange chromatography	GO:0003677;GO:0051276;GO:0005634	DNA binding;chromosome organization;nucleus	16.03.01;42.10.03;70.10	DNA binding;organization of chromosome structure;nucleus	15181449	This complex regulates telomere length. PTOP binds to the carboxyl terminus of POT1 and recruits it to telomeres.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Telomeric repeat-binding factor 2;Adrenocortical dysplasia protein homolog;TERF1-interacting nuclear factor 2;Protection of telomeres protein 1	TERF2;ACD;TINF2;POT1	TRBF2, TRF2;PIP1 PTOP TINT1 TPP1;TIN2;None
1199	Oligosaccharyltransferase complex (Stt3A variant)	Human	OST complex	None	P04843;P04844;P39656;P46977;P61803;Q9H0U3	6184;6185;1650;3703;1603;84061	MI:0028-cosedimentation in solution;MI:0226-ion exchange chromatography	GO:0006487;GO:0005783	protein N-linked glycosylation;endoplasmic reticulum	14.07.02.02;70.07	N-directed glycosylation, deglycosylation;endoplasmic reticulum	12887896	Oligosaccharyltransferase (OST) is an integral membrane protein that catalyzes N-linked glycosylation of nascent proteins in the lumen of the endoplasmic reticulum. Genomes of most multicellular eukaryotes encode two homologs of Stt3p and mammals express two homologs of Ost3p. Tissue and cell type-specific differences in expression of the Stt3p homologs suggest that the enzymatic properties of oligosaccharyltransferase are regulated in eukaryotes to respond to alterations in glycoprotein flux through the secretory pathway and may contribute to tissue-specific glycan heterogeneity.  Iag2 appears to be weakly associated with the OST complex and dissociates from the other subunits at various stages during enzyme purification.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1;Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2;Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit;Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A;Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1;Magnesium transporter protein 1	RPN1;RPN2;DDOST;STT3A;DAD1;MAGT1	None;None;KIAA0115 OST48;ITM1 TMC;None;IAG2
1200	Oligosaccharyltransferase complex (Stt3B variant)	Human	OST complex	None	P04843;P04844;P39656;P61803;Q13454;Q8TCJ2;Q9H0U3	6184;6185;1650;1603;7991;201595;84061	MI:0028-cosedimentation in solution;MI:0226-ion exchange chromatography	GO:0006487;GO:0005783	protein N-linked glycosylation;endoplasmic reticulum	14.07.02.02;70.07	N-directed glycosylation, deglycosylation;endoplasmic reticulum	12887896	Oligosaccharyltransferase (OST) is an integral membrane protein that catalyzes N-linked glycosylation of nascent proteins in the lumen of the endoplasmic reticulum. Genomes of most multicellular eukaryotes encode two homologs of Stt3p and mammals express two homologs of Ost3p. Tissue and cell type-specific differences in expression of the Stt3p homologs suggest that the enzymatic properties of oligosaccharyltransferase are regulated in eukaryotes to respond to alterations in glycoprotein flux through the secretory pathway and may contribute to tissue-specific glycan heterogeneity.  Tusc3 and Iag2 appear to be weakly associated with the OST complex and dissociate from the other subunits at various stages during enzyme purification.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1;Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2;Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit;Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1;Tumor suppressor candidate 3;Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B;Magnesium transporter protein 1	RPN1;RPN2;DDOST;DAD1;TUSC3;STT3B;MAGT1	None;None;KIAA0115 OST48;None;N33;SIMP;IAG2
1201	TRF1-TIN2 complex	Human	None	None	P54274;Q96AP0;Q9BSI4;Q9NUX5	7013;65057;26277;25913	MI:0007-anti tag coimmunoprecipitation	GO:0003677;GO:0051276;GO:0005634	DNA binding;chromosome organization;nucleus	16.03.01;42.10.03;70.10	DNA binding;organization of chromosome structure;nucleus	15231715	This complex regulates telomere length.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Telomeric repeat-binding factor 1;Adrenocortical dysplasia protein homolog;TERF1-interacting nuclear factor 2;Protection of telomeres protein 1	TERF1;ACD;TINF2;POT1	PIN2 TRBF1 TRF TRF1;PIP1 PTOP TINT1 TPP1;TIN2;None
1202	TRF1 telomere length regulation complex	Human	None	None	O95271;P54274;Q9BSI4	8658;7013;26277	MI:0006-anti bait coimmunoprecipitation	GO:0051276;GO:0005634	chromosome organization;nucleus	42.10.03;70.10	organization of chromosome structure;nucleus	15133513	Inhibition of TRF1 by tankyrase 1 is controlled by TIN2.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Poly [ADP-ribose] polymerase tankyrase-1;Telomeric repeat-binding factor 1;TERF1-interacting nuclear factor 2	TNKS;TERF1;TINF2	PARP5A PARPL TIN1 TINF1 TNKS1;PIN2 TRBF1 TRF TRF1;TIN2
1204	Rap1 complex	Human	None	None	P54274;Q15554;Q92878;Q96AP0;Q9BSI4;Q9NUX5;Q9NYB0	7013;7014;10111;65057;26277;25913;54386	MI:0007-anti tag coimmunoprecipitation	GO:0003677;GO:0051276;GO:0005634	DNA binding;chromosome organization;nucleus	16.03.01;42.10.03;70.10	DNA binding;organization of chromosome structure;nucleus	15316005	TIN2 was found to bind TRF1 and TRF2 simultaneously, showing that TIN2 can link these telomeric proteins. This connection appeared to stabilize TRF2 on the telomeres as the treatment of cells with TIN2 small interfering RNA resulted in a decreased presence of TRF2 and hRap1 at chromosome ends. Only 5-10% of the endogenous TRF1 could be recovered in association with the hRap1 complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Telomeric repeat-binding factor 1;Telomeric repeat-binding factor 2;DNA repair protein RAD50;Adrenocortical dysplasia protein homolog;TERF1-interacting nuclear factor 2;Protection of telomeres protein 1;Telomeric repeat-binding factor 2-interacting protein 1	TERF1;TERF2;RAD50;ACD;TINF2;POT1;TERF2IP	PIN2 TRBF1 TRF TRF1;TRBF2, TRF2;None;PIP1 PTOP TINT1 TPP1;TIN2;None;DRIP5, RAP1
1205	TRF2-Rap1 complex III	Human	None	None	Q15554;Q9NYB0	7014;54386	MI:0071-molecular sieving	GO:0003677;GO:0051276;GO:0005634	DNA binding;chromosome organization;nucleus	16.03.01;42.10.03;70.10	DNA binding;organization of chromosome structure;nucleus	15316005	The TRF2 complex is primarily involved in telomere protection and contains the TRF2 interacting partner human (h)Rap1 as well as several factors involved in the DNA damage response.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Telomeric repeat-binding factor 2;Telomeric repeat-binding factor 2-interacting protein 1	TERF2;TERF2IP	TRBF2, TRF2;DRIP5, RAP1
1206	TRF-Rap1 complex I, 2MD	Human	None	None	O95271;P54274;Q15554;Q9BSI4;Q9NUX5;Q9NYB0	8658;7013;7014;26277;25913;54386	MI:0071-molecular sieving	GO:0003677;GO:0051276;GO:0005634	DNA binding;chromosome organization;nucleus	16.03.01;42.10.03;70.10	DNA binding;organization of chromosome structure;nucleus	15316005	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Poly [ADP-ribose] polymerase tankyrase-1;Telomeric repeat-binding factor 1;Telomeric repeat-binding factor 2;TERF1-interacting nuclear factor 2;Protection of telomeres protein 1;Telomeric repeat-binding factor 2-interacting protein 1	TNKS;TERF1;TERF2;TINF2;POT1;TERF2IP	PARP5A PARPL TIN1 TINF1 TNKS1;PIN2 TRBF1 TRF TRF1;TRBF2, TRF2;TIN2;None;DRIP5, RAP1
1207	TRF2-Rap1 complex II	Human	None	None	Q15554;Q9BSI4;Q9NUX5;Q9NYB0	7014;26277;25913;54386	MI:0071-molecular sieving	GO:0003677;GO:0051276;GO:0005634	DNA binding;chromosome organization;nucleus	16.03.01;42.10.03;70.10	DNA binding;organization of chromosome structure;nucleus	15316005	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Telomeric repeat-binding factor 2;TERF1-interacting nuclear factor 2;Protection of telomeres protein 1;Telomeric repeat-binding factor 2-interacting protein 1	TERF2;TINF2;POT1;TERF2IP	TRBF2, TRF2;TIN2;None;DRIP5, RAP1
1211	Ubiquitin E3 ligase (AHR, ARNT, DDB1, TBL3, CUL4B, RBX1)	Human	CUL4AhR complex	MCF-7 cells	P27540;P35869;P62877;Q12788;Q13620;Q16531	405;196;9978;10607;8450;1642	MI:0007-anti tag coimmunoprecipitation	GO:0016567;GO:0043161;GO:0006511;GO:0023052;GO:0005634	protein ubiquitination;proteasome-mediated ubiquitin-dependent protein catabolic process;ubiquitin-dependent protein catabolic process;signaling;nucleus	14.07.05;14.13.01.01;30.01;70.10	modification by ubiquitination, deubiquitination;proteasomal degradation (ubiquitin/proteasomal pathway);cellular signalling;nucleus	17392787	AHR has dual functions. Besides being a transcription factor as subunit of the AHR-ARNT complex (CORUM-ID:8842), it also possesses an intrinsic E3 ubiquitin ligase function that targets, e.g., the steroid receptors for proteasomal degradation ( PMID: 30718831). . In the CUL4B(AhR) ubiquitin E3 ligase complex, ligand-activated dioxin receptor AHR acts as a substrate-specific adaptor component that targets sex steroid receptors for degradation. Thus, experiments uncover a function for AhR as an atypical component of the ubiquitin ligase complex and demonstrate a non-genomic signalling pathway in which fat-soluble ligands regulate target-protein-selective degradation through a ubiquitin ligase complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Aryl hydrocarbon receptor nuclear translocator;Aryl hydrocarbon receptor;E3 ubiquitin-protein ligase RBX1;Transducin beta-like protein 3;Cullin-4B;DNA damage-binding protein 1	ARNT;AHR;RBX1;TBL3;CUL4B;DDB1	BHLHE2;BHLHE76;RNF75 ROC1;SAZD;KIAA0695;XAP1
1214	Ubiquitin E3 ligase (DET1, DDB1, CUL4A, RBX1, COP1)	Human	DCXhDET1-hCOP1 complex	None	P62877;Q13619;Q16531;Q7L5Y6;Q8NHY2	9978;8451;1642;55070;64326	MI:0007-anti tag coimmunoprecipitation;MI:0069-mass spectrometry studies of complexes	GO:0016567;GO:0043161;GO:0006511;GO:0023052;GO:0005634	protein ubiquitination;proteasome-mediated ubiquitin-dependent protein catabolic process;ubiquitin-dependent protein catabolic process;signaling;nucleus	14.07.05;14.13.01.01;30.01;70.10	modification by ubiquitination, deubiquitination;proteasomal degradation (ubiquitin/proteasomal pathway);cellular signalling;nucleus	14739464	Ubiquitin E3 ligases covalently attach ubiquitin to a lysine residue on a target protein. Polyubiquitination marks proteins for degradation by the proteasome. Human DET1 (hDET1) promotes ubiquitination and degradation of the proto-oncogenic transcription factor c-Jun by assembling a multisubunit ubiquitin E3 ligase. Ablation of any subunit by RNA interference stabilized c-Jun and increased c-Jun-activated transcription.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase RBX1;Cullin-4A;DNA damage-binding protein 1;DET1 homolog;E3 ubiquitin-protein ligase COP1	RBX1;CUL4A;DDB1;DET1;COP1	RNF75 ROC1;None;XAP1;None;RFWD2 RNF200
1215	Ubiquitin E3 ligase (FBXW7, CUL1, SKP1A, RBX1)	Human	None	None	P62877;P63208;Q13616;Q969H0	9978;6500;8454;55294	MI:0019-coimmunoprecipitation	GO:0016567;GO:0043161;GO:0006511;GO:0007219;GO:0023052	protein ubiquitination;proteasome-mediated ubiquitin-dependent protein catabolic process;ubiquitin-dependent protein catabolic process;Notch signaling pathway;signaling	14.07.05;14.13.01.01;30.05.02.14;30.01	modification by ubiquitination, deubiquitination;proteasomal degradation (ubiquitin/proteasomal pathway);Notch-receptor signalling pathway;cellular signalling	11585921	Ubiquitin E3 ligases covalently attach ubiquitin to a lysine residue on a target protein. Polyubiquitination marks proteins for degradation by the proteasome. FBXW7 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase RBX1;S-phase kinase-associated protein 1;Cullin-1;F-box/WD repeat-containing protein 7	RBX1;SKP1;CUL1;FBXW7	RNF75 ROC1;EMC19 OCP2 SKP1A TCEB1L;None;FBW7 FBX30 SEL10
1217	WRN-TRF2 complex	Human	None	HeLa cells	Q14191;Q15554	7486;7014	MI:0006-anti bait coimmunoprecipitation;MI:0096-pull down	GO:0004386;GO:0032204;GO:0005634;GO:0090398	helicase activity;regulation of telomere maintenance;nucleus;cellular senescence	70.10	nucleus	12181313	TRF2 interaction with WRN results in a stimulation of WRN-helicase activity.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN;Telomeric repeat-binding factor 2	WRN;TERF2	RECQ3 RECQL2;TRBF2, TRF2
1218	BLM-TRF2 complex	Human	None	HTC75 cells	P54132;Q15554	641;7014	MI:0006-anti bait coimmunoprecipitation;MI:0096-pull down	GO:0090398;GO:0032204;GO:0005634	cellular senescence;regulation of telomere maintenance;nucleus	70.10	nucleus	12768206	None	BLM is involved in Bloom syndrome (BS) (PMID:12444098).	None	Homo sapiens (Human);Homo sapiens (Human)	RecQ-like DNA helicase BLM;Telomeric repeat-binding factor 2	BLM;TERF2	RECQ2 RECQL3;TRBF2, TRF2
1219	Tankyrin 1-tankyrin 2-TRF1 complex	Human	None	None	O95271;P54274;Q9H2K2	8658;7013;80351	MI:0004-affinity chromatography technology	GO:0051276;GO:0005634	chromosome organization;nucleus	42.10.03;70.10	organization of chromosome structure;nucleus	12080061	TRF1 binding allows tankyrase to regulate telomere dynamics. Mouse TRF1 lacks the binding motif for tankyrase.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Poly [ADP-ribose] polymerase tankyrase-1;Telomeric repeat-binding factor 1;Poly [ADP-ribose] polymerase tankyrase-2	TNKS;TERF1;TNKS2	PARP5A PARPL TIN1 TINF1 TNKS1;PIN2 TRBF1 TRF TRF1;PARP5B TANK2 TNKL
1220	TRF2-Ku complex	Human	None	None	P12956;P13010;Q15554	2547;7520;7014	MI:0018-two hybrid;MI:0019-coimmunoprecipitation	GO:0003677;GO:0051276;GO:0005634	DNA binding;chromosome organization;nucleus	16.03.01;42.10.03;70.10	DNA binding;organization of chromosome structure;nucleus	10984620	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	X-ray repair cross-complementing protein 6;X-ray repair cross-complementing protein 5;Telomeric repeat-binding factor 2	XRCC6;XRCC5;TERF2	G22P1;G22P2;TRBF2, TRF2
1221	TFIIA-TRF2 complex	Human	None	None	P52655;P52657;Q15554	2957;2958;7014	MI:0007-anti tag coimmunoprecipitation	GO:2001141;GO:0006355;GO:0005634	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;nucleus	11.02.03.04;70.10	transcriptional control;nucleus	10570139	TRF2-TFIIA complex is able to replace TBP or TFIID in basal or activated transcription from various RNA polymerase II promoters.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transcription initiation factor IIA subunit 1;Transcription initiation factor IIA subunit 2;Telomeric repeat-binding factor 2	GTF2A1;GTF2A2;TERF2	TF2A1;TF2A2;TRBF2, TRF2
1223	H2AX complex, isolated from cells without IR exposure	Human	None	None	O43390;P05455;P06748;P0DP23;P11021;P11940;P16104;P27797;P62805;Q08945;Q8N257;Q9Y262;Q9Y5B9	10236;6741;4869;801;3309;26986;3014;811;None;6749;128312;51386;11198	MI:0004-affinity chromatography technology;MI:0069-mass spectrometry studies of complexes	GO:0006265;GO:0000075;GO:0006354;GO:0051276;GO:0005634	DNA topological change;cell cycle checkpoint signaling;DNA-templated transcription elongation;chromosome organization;nucleus	10.01.09.05;10.03.01.03;11.02.03.01.04;42.10.03;70.10	DNA conformation modification (e.g. chromatin);cell cycle checkpoints (checkpoints of morphogenesis, DNA-damage,-replication, mitotic phase and spindle);transcription elongation;organization of chromosome structure;nucleus	16522924	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Heterogeneous nuclear ribonucleoprotein R;Lupus La protein;Nucleophosmin;Calmodulin-1;Endoplasmic reticulum chaperone BiP;Polyadenylate-binding protein 1;Histone H2AX;Calreticulin;Histone H4;FACT complex subunit SSRP1;Histone H2B type 3-B;Eukaryotic translation initiation factor 3 subunit L;FACT complex subunit SPT16	HNRNPR;SSB;NPM1;CALM1;HSPA5;PABPC1;H2AX;CALR;H4C1;SSRP1;H2BC26;EIF3L;SUPT16H	HNRPR;None;NPM;CALM CAM CAM1;GRP78;PAB1 PABP PABP1 PABPC2;H2AFX;CRTC;H4/A H4FA HIST1H4A;FACT80;H2BU1 HIST3H2BB;EIF3EIP EIF3S6IP;FACT140 FACTP140
1224	Ubiquitin E3 ligase (BMI1, SPOP, CUL3)	Human	None	None	O43791;P35226;Q13618	8405;648;8452	MI:0019-coimmunoprecipitation	GO:0009048;GO:0016567;GO:0005634;GO:0006511	dosage compensation by inactivation of X chromosome;protein ubiquitination;nucleus;ubiquitin-dependent protein catabolic process	10.03.04.06;14.07.05;70.10;14.13.01.01	chromosome inactivation;modification by ubiquitination, deubiquitination;nucleus;proteasomal degradation (ubiquitin/proteasomal pathway)	15897469	Ubiquitin E3 ligases covalently attach ubiquitin to a lysine residue on a target protein. Polyubiquitination marks proteins for degradation by the proteasome. X inactivation involves the stable silencing of one of the two X chromosomes in XX female mammals. Initiation of this process occurs during early development and involves Xist (X-inactive-specific transcript) RNA coating and the recruitment of Polycomb repressive complex (PRC) 2 and PRC1 proteins. This recruitment results in an inactive state that is initially labile but is further locked in by epigenetic marks such as DNA methylation, histone hypoacetylation, and MACROH2A deposition. The ubiquitin E3 ligase consisting of SPOP and CULLIN3 is able to ubiquitinate the Polycomb group protein BMI1 and the variant histone H2AFY.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Speckle-type POZ protein;Polycomb complex protein BMI-1;Cullin-3	SPOP;BMI1;CUL3	None;PCGF4 RNF51;KIAA0617
1225	Ubiquitin E3 ligase (H2AFY, SPOP, CUL3)	Human	None	None	O43791;O75367;Q13618	8405;9555;8452	MI:0019-coimmunoprecipitation	GO:0009048;GO:0016567;GO:0005634;GO:0006511	dosage compensation by inactivation of X chromosome;protein ubiquitination;nucleus;ubiquitin-dependent protein catabolic process	10.03.04.06;14.07.05;70.10;14.13.01.01	chromosome inactivation;modification by ubiquitination, deubiquitination;nucleus;proteasomal degradation (ubiquitin/proteasomal pathway)	15897469	Ubiquitin E3 ligases covalently attach ubiquitin to a lysine residue on a target protein. Polyubiquitination marks proteins for degradation by the proteasome. X inactivation involves the stable silencing of one of the two X chromosomes in XX female mammals. Initiation of this process occurs during early development and involves Xist (X-inactive-specific transcript) RNA coating and the recruitment of Polycomb repressive complex (PRC) 2 and PRC1 proteins. This recruitment results in an inactive state that is initially labile but is further locked in by epigenetic marks such as DNA methylation, histone hypoacetylation, and MACROH2A deposition. The ubiquitin E3 ligase consisting of SPOP and CULLIN3 is able to ubiquitinate the Polycomb group protein BMI1 and the variant histone H2AFY.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Speckle-type POZ protein;Core histone macro-H2A.1;Cullin-3	SPOP;MACROH2A1;CUL3	None;H2AFY;KIAA0617
1226	H2AX complex I	Human	None	None	P06748;P09874;P11021;P16104;P27797;Q7L2E3;Q8N257	4869;142;3309;3014;811;22907;128312	MI:0004-affinity chromatography technology;MI:0069-mass spectrometry studies of complexes	GO:0006281;GO:0006265;GO:0000075;GO:0006354;GO:0006974;GO:0051276;GO:0005634	DNA repair;DNA topological change;cell cycle checkpoint signaling;DNA-templated transcription elongation;cellular response to DNA damage stimulus;chromosome organization;nucleus	10.01.05.01;10.01.09.05;10.03.01.03;11.02.03.01.04;32.01.09;42.10.03;70.10	DNA repair;DNA conformation modification (e.g. chromatin);cell cycle checkpoints (checkpoints of morphogenesis, DNA-damage,-replication, mitotic phase and spindle);transcription elongation;DNA damage response;organization of chromosome structure;nucleus	16522924	This complex has been isolated from cells after IR exposure and recovery for 30 minutes.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Nucleophosmin;Poly [ADP-ribose] polymerase 1;Endoplasmic reticulum chaperone BiP;Histone H2AX;Calreticulin;ATP-dependent RNA helicase DHX30;Histone H2B type 3-B	NPM1;PARP1;HSPA5;H2AX;CALR;DHX30;H2BC26	NPM;ADPRT PPOL;GRP78;H2AFX;CRTC;DDX30 KIAA0890;H2BU1 HIST3H2BB
1227	H2AX complex II	Human	None	None	P06748;P11021;P16104;P16989;P27797;P33778;P62805;Q8N257;Q96EY7;Q99879	4869;3309;3014;8531;811;3018;None;128312;55037;8342	MI:0004-affinity chromatography technology;MI:0069-mass spectrometry studies of complexes	GO:0006281;GO:0006265;GO:0000075;GO:0006354;GO:0006974;GO:0051276;GO:0005634	DNA repair;DNA topological change;cell cycle checkpoint signaling;DNA-templated transcription elongation;cellular response to DNA damage stimulus;chromosome organization;nucleus	10.01.05.01;10.01.09.05;10.03.01.03;11.02.03.01.04;32.01.09;42.10.03;70.10	DNA repair;DNA conformation modification (e.g. chromatin);cell cycle checkpoints (checkpoints of morphogenesis, DNA-damage,-replication, mitotic phase and spindle);transcription elongation;DNA damage response;organization of chromosome structure;nucleus	16522924	This complex has been isolated from cells after IR exposure and recovery for 2.5h.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Nucleophosmin;Endoplasmic reticulum chaperone BiP;Histone H2AX;Y-box-binding protein 3;Calreticulin;Histone H2B type 1-B;Histone H4;Histone H2B type 3-B;Pentatricopeptide repeat domain-containing protein 3, mitochondrial;Histone H2B type 1-M	NPM1;HSPA5;H2AX;YBX3;CALR;H2BC3;H4C1;H2BC26;PTCD3;H2BC14	NPM;GRP78;H2AFX;CSDA DBPA;CRTC;H2BFF HIST1H2BB;H4/A H4FA HIST1H4A;H2BU1 HIST3H2BB;MRPS39;H2BFE HIST1H2BM
1230	WINAC complex	Human	WSTF containing complex	None	O14497;O96019;P11473;P51531;P51532;Q02880;Q12824;Q13111;Q8TAQ2;Q92922;Q969G3;Q96GM5;Q9UIG0;Q9Y5B9	8289;86;7421;6595;6597;7155;6598;10036;6601;6599;6605;6602;9031;11198	MI:0004-affinity chromatography technology;MI:0006-anti bait coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0006260;GO:0006265;GO:0000084;GO:2001141;GO:0006355;GO:0051276;GO:0005634;GO:0005102	DNA replication;DNA topological change;mitotic S phase;regulation of RNA biosynthetic process;regulation of DNA-templated transcription;chromosome organization;nucleus;signaling receptor binding	10.01.03;10.01.09.05;10.03.01.01.05;11.02.03.04;42.10.03;70.10;16.01.01	DNA synthesis and replication;DNA conformation modification (e.g. chromatin);S phase of mitotic cell cycle;transcriptional control;organization of chromosome structure;nucleus;receptor binding	12837248	WINAC mediates the recruitment of unliganded VDR to VDR target sites in promoters, while subsequent binding of coregulators requires ligand binding.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	AT-rich interactive domain-containing protein 1A;Actin-like protein 6A;Vitamin D3 receptor;Probable global transcription activator SNF2L2;Transcription activator BRG1;DNA topoisomerase 2-beta;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1;Chromatin assembly factor 1 subunit A;SWI/SNF complex subunit SMARCC2;SWI/SNF complex subunit SMARCC1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1;Tyrosine-protein kinase BAZ1B;FACT complex subunit SPT16	ARID1A;ACTL6A;VDR;SMARCA2;SMARCA4;TOP2B;SMARCB1;CHAF1A;SMARCC2;SMARCC1;SMARCE1;SMARCD1;BAZ1B;SUPT16H	BAF250 BAF250A C1orf4 OSA1 SMARCF1;BAF53 BAF53A INO80K;NR1I1;BAF190B BRM SNF2A SNF2L2;BAF190A BRG1 SNF2B SNF2L4;None;BAF47, INI1, SNF5L1;CAF CAF1P150;BAF170;BAF155;BAF57;BAF60A;WBSC10 WBSCR10 WBSCR9 WSTF;FACT140 FACTP140
1231	FIB-associated protein complex	Human	None	kidney	O14744;P22087;Q07021;Q71U36;Q99873;Q9H4B7	10419;2091;708;7846;3276;81027	MI:0007-anti tag coimmunoprecipitation	GO:0006364;GO:0000154;GO:0042254;GO:0005634	rRNA processing;rRNA modification;ribosome biogenesis;nucleus	11.04.01;11.06.01;12.01;70.10	rRNA processing;rRNA modification;ribosome biogenesis;nucleus	14583623	FIB-associated protein complexes contain a number of ribosomal proteins and potential trans-acting factors involved in ribosome biogenesis, and the complexes are dependent on RNA integrity.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein arginine N-methyltransferase 5;rRNA 2'-O-methyltransferase fibrillarin;Complement component 1 Q subcomponent-binding protein, mitochondrial;Tubulin alpha-1A chain;Protein arginine N-methyltransferase 1;Tubulin beta-1 chain	PRMT5;FBL;C1QBP;TUBA1A;PRMT1;TUBB1	HRMT1L5 IBP72 JBP1 SKB1;FIB1 FLRN;GC1QBP HABP1 SF2P32;TUBA3;HMT2 HRMT1L2 IR1B4;None
1232	REST-CoREST-mSIN3A complex	Human	None	HEK-293 cells,	Q13127;Q96ST3;Q9UKL0	5978;25942;23186	MI:0007-anti tag coimmunoprecipitation	GO:0045892;GO:0022008;GO:0048699;GO:0030182;GO:0007399;GO:0005634	negative regulation of DNA-templated transcription;neurogenesis;generation of neurons;neuron differentiation;nervous system development;nucleus	11.02.03.04.03;41.05.13;43.03.13;47.03.01;70.10	transcription repression;neurogenesis;neuron;nervous system;nucleus	10734093	The REST-mSin3A association involves the NH(2)-terminal repressor domain of REST and the paired amphipathic helix 2 domain of mSin3A. REST forms complexes with endogenous mSin3A in mammalian cells, and both mSin3A and CoREST interact with REST in intact mammalian cells.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	RE1-silencing transcription factor;Paired amphipathic helix protein Sin3a;REST corepressor 1	REST;SIN3A;RCOR1	NRSF XBR;None;KIAA0071 RCOR
1233	CoREST-HDAC2 complex	Human	None	non-neuronal COS 1 cells, neuronal PC12 cells	Q92769;Q9UKL0	3066;23186	MI:0019-coimmunoprecipitation	GO:0006265;GO:0045892;GO:0006476;GO:0051276;GO:0005634	DNA topological change;negative regulation of DNA-templated transcription;protein deacetylation;chromosome organization;nucleus	10.01.09.05;11.02.03.04.03;14.07.04;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription repression;modification by acetylation, deacetylation;organization of chromosome structure;nucleus	11516394	In the presence of REST, the CoREST/HDAC2 complex represses transcription of the Nav1.2 sodium channel gene.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Histone deacetylase 2;REST corepressor 1	HDAC2;RCOR1	None;KIAA0071 RCOR
1237	BAF complex	Human	SWI/SNF complex A	None	O14497;O96019;P51531;P51532;Q12824;Q8TAQ2;Q92922;Q969G3;Q96GM5	8289;86;6595;6597;6598;6601;6599;6605;6602	MI:0004-affinity chromatography technology;MI:0006-anti bait coimmunoprecipitation	GO:0006265;GO:0045893;GO:0003677;GO:0051276;GO:0005634	DNA topological change;positive regulation of DNA-templated transcription;DNA binding;chromosome organization;nucleus	10.01.09.05;11.02.03.04.01;16.03.01;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription activation;DNA binding;organization of chromosome structure;nucleus	11073988	BAF250 confers specificity to the human BAF complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions.	None	Another subunit of the complex was found in the analysis, which has not been further characterized: BAF110.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	AT-rich interactive domain-containing protein 1A;Actin-like protein 6A;Probable global transcription activator SNF2L2;Transcription activator BRG1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1;SWI/SNF complex subunit SMARCC2;SWI/SNF complex subunit SMARCC1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1	ARID1A;ACTL6A;SMARCA2;SMARCA4;SMARCB1;SMARCC2;SMARCC1;SMARCE1;SMARCD1	BAF250 BAF250A C1orf4 OSA1 SMARCF1;BAF53 BAF53A INO80K;BAF190B BRM SNF2A SNF2L2;BAF190A BRG1 SNF2B SNF2L4;BAF47, INI1, SNF5L1;BAF170;BAF155;BAF57;BAF60A
1238	PBAF complex (Polybromo- and BAF containing complex)	Human	SWI/SNF-B complex	T47D cells	O96019;P51532;Q12824;Q68CP9;Q86U86;Q8TAQ2;Q92922;Q969G3;Q96GM5	86;6597;6598;196528;55193;6601;6599;6605;6602	MI:0004-affinity chromatography technology;MI:0006-anti bait coimmunoprecipitation	GO:0006265;GO:0045893;GO:0003677;GO:0009755;GO:0023052;GO:0051276;GO:0005694	DNA topological change;positive regulation of DNA-templated transcription;DNA binding;hormone-mediated signaling pathway;signaling;chromosome organization;chromosome	10.01.09.05;11.02.03.04.01;16.03.01;30.01.09.08;30.01;42.10.03;70.10.03	DNA conformation modification (e.g. chromatin);transcription activation;DNA binding;hormone mediated signal transduction;cellular signalling;organization of chromosome structure;chromosome	11780067	The chromatin-remodeling complex PBAF facilitates gene activation by assisting transcription machinery to gain access to targets on the chromosome.	None	Two other subunits of the complex were found in the analysis, which have not been further characterized: BAF110 and BAF240.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Actin-like protein 6A;Transcription activator BRG1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1;AT-rich interactive domain-containing protein 2;Protein polybromo-1;SWI/SNF complex subunit SMARCC2;SWI/SNF complex subunit SMARCC1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1	ACTL6A;SMARCA4;SMARCB1;ARID2;PBRM1;SMARCC2;SMARCC1;SMARCE1;SMARCD1	BAF53 BAF53A INO80K;BAF190A BRG1 SNF2B SNF2L4;BAF47, INI1, SNF5L1;BAF200 KIAA1557;BAF180 PB1;BAF170;BAF155;BAF57;BAF60A
1239	EBAFb complex	Human	ENL-associated BAF250b-containing SWI/SNF complex	None	O96019;P51532;Q03111;Q12824;Q8NFD5;Q8TAQ2;Q92922;Q92925;Q969G3;Q96GM5	86;6597;4298;6598;57492;6601;6599;6603;6605;6602	MI:0006-anti bait coimmunoprecipitation;MI:0071-molecular sieving	GO:0006265;GO:0045893;GO:0003677;GO:0051276;GO:0005694	DNA topological change;positive regulation of DNA-templated transcription;DNA binding;chromosome organization;chromosome	10.01.09.05;11.02.03.04.01;16.03.01;42.10.03;70.10.03	DNA conformation modification (e.g. chromatin);transcription activation;DNA binding;organization of chromosome structure;chromosome	12665591	ENL associates and cooperates with SWI/SNF complexes to activate transcription of the promoter of HoxA7, a downstream target essential for oncogenic activity of ENL.	None	Three other subunits of the complex were found in the analysis, which have not been further characterized: EBAF140, EBAF100 and EBAF70.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Actin-like protein 6A;Transcription activator BRG1;Protein ENL;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1;AT-rich interactive domain-containing protein 1B;SWI/SNF complex subunit SMARCC2;SWI/SNF complex subunit SMARCC1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1	ACTL6A;SMARCA4;MLLT1;SMARCB1;ARID1B;SMARCC2;SMARCC1;SMARCD2;SMARCE1;SMARCD1	BAF53 BAF53A INO80K;BAF190A BRG1 SNF2B SNF2L4;ENL LTG19 YEATS1;BAF47, INI1, SNF5L1;BAF250B DAN15 KIAA1235 OSA2;BAF170;BAF155;BAF60B;BAF57;BAF60A
1243	Ubiquitin E3 ligase (SPOP, DAXX, CUL3)	Human	None	None	O43791;Q13618;Q9UER7	8405;8452;1616	MI:0007-anti tag coimmunoprecipitation	GO:2001141;GO:0006355;GO:0016567;GO:0043161;GO:0006511;GO:0043067;GO:0005634	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;protein ubiquitination;proteasome-mediated ubiquitin-dependent protein catabolic process;ubiquitin-dependent protein catabolic process;regulation of programmed cell death;nucleus	11.02.03.04;14.07.05;14.13.01.01;40.10.02.04;70.10	transcriptional control;modification by ubiquitination, deubiquitination;proteasomal degradation (ubiquitin/proteasomal pathway);regulation of apoptosis;nucleus	16524876	Ubiquitin E3 ligases covalently attach ubiquitin to a lysine residue on a target protein. Polyubiquitination marks proteins for degradation by the proteasome. SPOP serves as an adaptor of Daxx for the ubiquitination by Cul3-based ubiquitin ligase and subsequent degradation by the proteasome. Experiments suggest that SPOP/Cul3-ubiquitin ligase plays an essential role in the control of Daxx level and, thus, in the regulation of Daxx-mediated cellular processes, including transcriptional regulation and apoptosis.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Speckle-type POZ protein;Cullin-3;Death domain-associated protein 6	SPOP;CUL3;DAXX	None;KIAA0617;BING2 DAP6
1245	Protein phosphatase 4 complex	Human	PPP4; PPP4c	None	P60510;Q9NY27	5531;151987	MI:0028-cosedimentation in solution	GO:0006470;GO:0005813;GO:0000226	protein dephosphorylation;centrosome;microtubule cytoskeleton organization	14.07.03;70.05;42.04.05	modification by phosphorylation, dephosphorylation, autophosphorylation;centrosome;microtubule cytoskeleton	10769191	Protein phosphatase 4 (PPP4) is a protein serine/threonine phosphatase that has been implicated in microtubule organization at centrosomes.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein phosphatase 4 catalytic subunit;Serine/threonine-protein phosphatase 4 regulatory subunit 2	PPP4C;PPP4R2	PPP4 PPX;None
1248	Apoptosome	Human	None	None	O14727;P99999	317;54205	MI:0114-x-ray crystallography	GO:0006915;GO:0005737	apoptotic process;cytoplasm	40.10.02;70.03	apoptosis (type I programmed cell death);cytoplasm	16271896	The apoptosome is a multiprotein complex mediating the mitochondrial pathway of cell death. Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. In the absence of an apoptotic signal, Apaf-1 exists in a monomeric form.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Apoptotic protease-activating factor 1;Cytochrome c	APAF1;CYCS	KIAA0413;CYC
1250	RB1-E2F1 complex	Human	None	MCF7 cells	P06400;Q01094	5925;1869	MI:0019-coimmunoprecipitation	GO:0006974;GO:0005634;GO:0051726;GO:0006355	cellular response to DNA damage stimulus;nucleus;regulation of cell cycle;regulation of DNA-templated transcription	32.01.09;70.10;10.03.01;11.02.03.04	DNA damage response;nucleus;mitotic cell cycle and cell cycle control;transcriptional control	17380128	The phosphorylation of pRB at Ser612 is induced by ATM-Chk1/2 kinase after DNA damage, leading to enhancement of the formation of a complex between pRB and E2F-1. It is proposed, that in asynchronously growing cells, pRB exists in a predominantly phosphorylated state, which is dissociated from E2F, allowing E2F-dependent transcription. DNA damage induces dephosphorylation of pRB at Cdk phosphorylation sites, leading to the complex pRB-E2F-1 being formed. DNA damage also activates ATM kinase and transduces signals to the checkpoint kinases Chk1 and Chk2. Activated Chk1 and Chk2 phosphorylate Ser612 of pRB and this phosphorylation enhances the formation of a complex between pRB and E2F-1, leading to repression of the transcriptional activity of E2F-1. Consequently, pRB-dependent cell cycle arrest and repression of apoptosis occur.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Retinoblastoma-associated protein;Transcription factor E2F1	RB1;E2F1	None;RBBP3
1251	BAF complex	Human	SWI/SNF-A complex	None	O14497;O96019;P51531;Q12824;Q8TAQ2;Q92922;Q969G3;Q96GM5	8289;86;6595;6598;6601;6599;6605;6602	MI:0071-molecular sieving	GO:0006265;GO:0045893;GO:0003677;GO:0051276;GO:0005694	DNA topological change;positive regulation of DNA-templated transcription;DNA binding;chromosome organization;chromosome	10.01.09.05;11.02.03.04.01;16.03.01;42.10.03;70.10.03	DNA conformation modification (e.g. chromatin);transcription activation;DNA binding;organization of chromosome structure;chromosome	12665591	BAF complex belongs to chromatin remodeling complexes.	None	Since the authors did not specify SMARCA, we used SMARCA2.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	AT-rich interactive domain-containing protein 1A;Actin-like protein 6A;Probable global transcription activator SNF2L2;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1;SWI/SNF complex subunit SMARCC2;SWI/SNF complex subunit SMARCC1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1	ARID1A;ACTL6A;SMARCA2;SMARCB1;SMARCC2;SMARCC1;SMARCE1;SMARCD1	BAF250 BAF250A C1orf4 OSA1 SMARCF1;BAF53 BAF53A INO80K;BAF190B BRM SNF2A SNF2L2;BAF47, INI1, SNF5L1;BAF170;BAF155;BAF57;BAF60A
1252	EBAFa complex	Human	ENL-associated BAF250a-containing SWI/SNF complex	None	O14497;O96019;P51532;Q03111;Q12824;Q8TAQ2;Q92922;Q92925;Q969G3;Q96GM5	8289;86;6597;4298;6598;6601;6599;6603;6605;6602	MI:0006-anti bait coimmunoprecipitation;MI:0071-molecular sieving	GO:0006265;GO:0045893;GO:0003677;GO:0051276;GO:0005694	DNA topological change;positive regulation of DNA-templated transcription;DNA binding;chromosome organization;chromosome	10.01.09.05;11.02.03.04.01;16.03.01;42.10.03;70.10.03	DNA conformation modification (e.g. chromatin);transcription activation;DNA binding;organization of chromosome structure;chromosome	12665591	ENL associates and cooperates with SWI/SNF complexes to activate transcription of the promoter of HoxA7, a downstream target essential for oncogenic activity of ENL.	None	Three other subunits of the complex were found in the analysis, which have not been further characterized: EBAF140, EBAF100 and EBAF70.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	AT-rich interactive domain-containing protein 1A;Actin-like protein 6A;Transcription activator BRG1;Protein ENL;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1;SWI/SNF complex subunit SMARCC2;SWI/SNF complex subunit SMARCC1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1	ARID1A;ACTL6A;SMARCA4;MLLT1;SMARCB1;SMARCC2;SMARCC1;SMARCD2;SMARCE1;SMARCD1	BAF250 BAF250A C1orf4 OSA1 SMARCF1;BAF53 BAF53A INO80K;BAF190A BRG1 SNF2B SNF2L4;ENL LTG19 YEATS1;BAF47, INI1, SNF5L1;BAF170;BAF155;BAF60B;BAF57;BAF60A
1254	Menin-associated histone methyltransferase complex	Human	menin HMTase complex	None	O00255;P30876;P61964;Q15291;Q9C005;Q9UBL3;Q9UMN6	4221;5431;11091;5929;84661;9070;None	MI:0006-anti bait coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0006265;GO:0006349;GO:0045893;GO:0006479;GO:0051276;GO:0030154;GO:0005634	DNA topological change;regulation of gene expression by genomic imprinting;positive regulation of DNA-templated transcription;protein methylation;chromosome organization;cell differentiation;nucleus	10.01.09.05;10.01.09.07;11.02.03.04.01;14.07.09;42.10.03;40.02;70.10	DNA conformation modification (e.g. chromatin);DNA imprinting and other epigenetic effects;transcription activation;posttranslational modification of amino acids (e.g. hydroxylation, methylation);organization of chromosome structure;cell differentiation;nucleus	14992727	The menin-associated complex methylates histone H3 on lysine 4, suggesting menin activates the transcription of differentiation-regulating genes by covalent histone modification, and that this activity is related to tumor suppression by MEN1.	MEN1 gene is mutated in familial multiple endocrine neoplasia type 1.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Menin;DNA-directed RNA polymerase II subunit RPB2;WD repeat-containing protein 5;Retinoblastoma-binding protein 5;Protein dpy-30 homolog;Set1/Ash2 histone methyltransferase complex subunit ASH2;Histone-lysine N-methyltransferase 2B	MEN1;POLR2B;WDR5;RBBP5;DPY30;ASH2L;KMT2B	SCG2;None;BIG3;RBQ3;None;ASH2L1;HRX2 KIAA0304 MLL2 MLL4 TRX2 WBP7
1255	Ubiquitin E3 ligase (SIAH1, SIP, SKP1A, TBL1X)	Human	None	None	O60907;P63208;Q8IUQ4;Q9HB71	6907;6500;6477;27101	MI:0018-two hybrid;MI:0019-coimmunoprecipitation	GO:0016567;GO:0043161;GO:0006511;GO:0023052	protein ubiquitination;proteasome-mediated ubiquitin-dependent protein catabolic process;ubiquitin-dependent protein catabolic process;signaling	14.07.05;14.13.01.01;30.01	modification by ubiquitination, deubiquitination;proteasomal degradation (ubiquitin/proteasomal pathway);cellular signalling	11389839	Ubiquitin E3 ligases covalently attach ubiquitin to a lysine residue on a target protein. Polyubiquitination marks proteins for degradation by the proteasome. Conditional degradation of beta-catenin represents a central event in the Wnt signaling pathways controlling cell fate and proliferation. A network of protein interactions in which Siah, SIP (a novel Siah-interacting protein), Skp1, and Ebi collaborate in a pathway controlling beta-catenin levels, affecting activity of beta-catenin-dependent Tcf/LEF transcription factors.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	F-box-like/WD repeat-containing protein TBL1X;S-phase kinase-associated protein 1;E3 ubiquitin-protein ligase SIAH1;Calcyclin-binding protein	TBL1X;SKP1;SIAH1;CACYBP	TBL1;EMC19 OCP2 SKP1A TCEB1L;HUMSIAH;S100A6BP SIP
1256	MLL-HCF complex	Human	None	None	O00255;P05546;P51610;P61964;Q03164;Q15291;Q9UBL3	4221;3053;3054;11091;4297;5929;9070	MI:0006-anti bait coimmunoprecipitation;MI:0226-ion exchange chromatography	GO:0006265;GO:0006349;GO:2001141;GO:0006355;GO:0006479;GO:0051276;GO:0005634	DNA topological change;regulation of gene expression by genomic imprinting;regulation of RNA biosynthetic process;regulation of DNA-templated transcription;protein methylation;chromosome organization;nucleus	10.01.09.05;10.01.09.07;11.02.03.04;14.07.09;42.10.03;70.10	DNA conformation modification (e.g. chromatin);DNA imprinting and other epigenetic effects;transcriptional control;posttranslational modification of amino acids (e.g. hydroxylation, methylation);organization of chromosome structure;nucleus	15199122	This complex links the menin tumor suppressor protein to the MLL histone methyltransferase machinery.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Menin;Heparin cofactor 2;Host cell factor 1;WD repeat-containing protein 5;Histone-lysine N-methyltransferase 2A;Retinoblastoma-binding protein 5;Set1/Ash2 histone methyltransferase complex subunit ASH2	MEN1;SERPIND1;HCFC1;WDR5;KMT2A;RBBP5;ASH2L	SCG2;HCF2;HCF1, HFC1;BIG3;ALL1 CXXC7 HRX HTRX MLL MLL1 TRX1;RBQ3;ASH2L1
1257	ALL-1 supercomplex	Human	None	None	O00422;O60264;O60341;O75446;O94776;O95983;P20226;P21675;P49848;P51531;P61964;P62826;Q03164;Q09028;Q12824;Q12873;Q13547;Q15029;Q15291;Q16514;Q16576;Q16594;Q8TAQ2;Q92769;Q92797;Q92922;Q96ST3;Q9P2I0	10284;8467;23028;8819;9219;53615;6908;6872;6878;6595;11091;5901;4297;5928;6598;1107;3065;9343;5929;6883;5931;6880;6601;3066;8189;6599;25942;53981	MI:0004-affinity chromatography technology;MI:0071-molecular sieving	GO:0006265;GO:2001141;GO:0006355;GO:0006476;GO:0006479;GO:0051276;GO:0005634	DNA topological change;regulation of RNA biosynthetic process;regulation of DNA-templated transcription;protein deacetylation;protein methylation;chromosome organization;nucleus	10.01.09.05;11.02.03.04;14.07.04;14.07.09;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcriptional control;modification by acetylation, deacetylation;posttranslational modification of amino acids (e.g. hydroxylation, methylation);organization of chromosome structure;nucleus	12453419	The proteins associated with ALL-1 can be classified into eight groups. (1) BRM, BAF170, BAF155, and INI1, the core components of the ATP-dependent SWI/SNF nucleosome remodeling complex, (2) Mi2, MTA1-L1, HDAC1, HDAC2, RbAp46, RbAp48, MBD3, and KIAA0601, all components of the NuRD complex, (3) Sin3A, SAP30, SAP18, HDAC1, HDAC2, RbAp48, and RbAp46, components of the histone deacetylase Sin3A complex, (4) hSNF2H, homolog of ISWI, an ATP-dependent nucleosome remodeling and assembly factor, (5) TAFII250, TAFII80, TAFII31, TAFII20, and TBP, components of the TFIID complex, (6) RbBP5  and WDRP5, components of the yeast Set1 complex,  which methylates H3-K4. (7) Proteins involved in RNA processing, CPSF, Symplekin and EFTUD2. (8) Ran, which functions in nucleocytoplasmic transport and in spindle assembly during mitosis.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone deacetylase complex subunit SAP18;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5;Lysine-specific histone demethylase 1A;Histone deacetylase complex subunit SAP30;Metastasis-associated protein MTA2;Methyl-CpG-binding domain protein 3;TATA-box-binding protein;Transcription initiation factor TFIID subunit 1;Transcription initiation factor TFIID subunit 6;Probable global transcription activator SNF2L2;WD repeat-containing protein 5;GTP-binding nuclear protein Ran;Histone-lysine N-methyltransferase 2A;Histone-binding protein RBBP4;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1;Chromodomain-helicase-DNA-binding protein 3;Histone deacetylase 1;116 kDa U5 small nuclear ribonucleoprotein component;Retinoblastoma-binding protein 5;Transcription initiation factor TFIID subunit 12;Histone-binding protein RBBP7;Transcription initiation factor TFIID subunit 9;SWI/SNF complex subunit SMARCC2;Histone deacetylase 2;Symplekin;SWI/SNF complex subunit SMARCC1;Paired amphipathic helix protein Sin3a;Cleavage and polyadenylation specificity factor subunit 2	SAP18;SMARCA5;KDM1A;SAP30;MTA2;MBD3;TBP;TAF1;TAF6;SMARCA2;WDR5;RAN;KMT2A;RBBP4;SMARCB1;CHD3;HDAC1;EFTUD2;RBBP5;TAF12;RBBP7;TAF9;SMARCC2;HDAC2;SYMPK;SMARCC1;SIN3A;CPSF2	None;SNF2H, WCRF135;AOF2 KDM1 KIAA0601 LSD1;None;MTA1L1 PID;None;GTF2D1 TF2D TFIID;BA2R CCG1 CCGS TAF2A;TAF2E TAFII70;BAF190B BRM SNF2A SNF2L2;BIG3;ARA24;ALL1 CXXC7 HRX HTRX MLL MLL1 TRX1;RBAP48;BAF47, INI1, SNF5L1;None;RPD3L1;KIAA0031 SNRP116;RBQ3;TAF15 TAF2J TAFII20;RBAP46;TAF2G TAFII31;BAF170;None;SPK;BAF155;None;CPSF100, KIAA1367
1258	Ubiquitin E3 ligase (GLMN, FBXW8, SKP1A, RBX1)	Human	None	None	P62877;P63208;Q8N3Y1;Q92990	9978;6500;26259;11146	MI:0019-coimmunoprecipitation	GO:0016567;GO:0043161;GO:0006511;GO:0001570	protein ubiquitination;proteasome-mediated ubiquitin-dependent protein catabolic process;ubiquitin-dependent protein catabolic process;vasculogenesis	14.07.05;14.13.01.01;47.03.03	modification by ubiquitination, deubiquitination;proteasomal degradation (ubiquitin/proteasomal pathway);vascular organs	12904573	Ubiquitin E3 ligases covalently attach ubiquitin to a lysine residue on a target protein. Polyubiquitination marks proteins for degradation by the proteasome. Experiments suggest that ubiquitin E3 ligase (containing GLMN, FBXW8, SKP1A and RBX1) plays an important role in vascular morphogenesis.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase RBX1;S-phase kinase-associated protein 1;F-box/WD repeat-containing protein 8;Glomulin	RBX1;SKP1;FBXW8;GLMN	RNF75 ROC1;EMC19 OCP2 SKP1A TCEB1L;FBW6 FBW8 FBX29 FBXO29 FBXW6;FAP48 FAP68 VMGLOM
1259	Chromatin assembly complex (CAF-1 complex)	Human	None	HEKK293 cells	Q09028;Q13111;Q13112	5928;10036;8208	MI:0006-anti bait coimmunoprecipitation;MI:0071-molecular sieving	GO:0006260;GO:0006265;GO:0000084;GO:0051276;GO:0005634	DNA replication;DNA topological change;mitotic S phase;chromosome organization;nucleus	10.01.03;10.01.09.05;10.03.01.01.05;42.10.03;70.10	DNA synthesis and replication;DNA conformation modification (e.g. chromatin);S phase of mitotic cell cycle;organization of chromosome structure;nucleus	7600578	Caf-1 complex assembles nucleosomes in a replication-dependent manner.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone-binding protein RBBP4;Chromatin assembly factor 1 subunit A;Chromatin assembly factor 1 subunit B	RBBP4;CHAF1A;CHAF1B	RBAP48;CAF CAF1P150;CAF1A CAF1P60 MPHOSPH7 MPP7
1260	Neddylin ligase (FBXO11, SKP1, CUL1, RBX1)	Human	None	HEK 293 cells	P62877;P63208;Q13616;Q86XK2	9978;6500;8454;80204	MI:0007-anti tag coimmunoprecipitation	GO:0000338;GO:0016925;GO:0016926;GO:0045116;GO:0051090;GO:0005634;GO:0036211	protein deneddylation;protein sumoylation;protein desumoylation;protein neddylation;regulation of DNA-binding transcription factor activity;nucleus;protein modification process	14.07.07;18.02.09;70.10	modification by ubiquitin-related proteins;regulator of transcription factor;nucleus	17098746	FBXO11 promotes the neddylation of p53 and inhibits its transcriptional activity.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase RBX1;S-phase kinase-associated protein 1;Cullin-1;F-box only protein 11	RBX1;SKP1;CUL1;FBXO11	RNF75 ROC1;EMC19 OCP2 SKP1A TCEB1L;None;FBX11 PRMT9 VIT1
1261	SRm160/300 complex	Human	None	None	P08621;P09661;P62995;Q8IYB3;Q9UQ35	6625;6627;6434;10250;23524	MI:0019-coimmunoprecipitation	GO:0008380;GO:0003723;GO:0005634	RNA splicing;RNA binding;nucleus	11.04.03.01;16.03.03;70.10	splicing;RNA binding;nucleus	10339552	Exonic splicing enhancer (ESE) sequences are important for the recognition of splice sites in pre-mRNA. These sequences are bound by specific serine-arginine (SR) repeat proteins that promote the assembly of splicing complexes at adjacent splice sites. In a study, it was shown that SRm160/300 is required for a purine-rich ESE to promote the splicing of a pre-mRNA derived from the Drosophila doublesex gene. Results suggest a model for ESE function in which the SRm160/300 splicing coactivator promotes critical interactions between ESE-bound "activators" and the snRNP machinery of the spliceosome.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	U1 small nuclear ribonucleoprotein 70 kDa;U2 small nuclear ribonucleoprotein A';Transformer-2 protein homolog beta;Serine/arginine repetitive matrix protein 1;Serine/arginine repetitive matrix protein 2	SNRNP70;SNRPA1;TRA2B;SRRM1;SRRM2	RNPU1Z RPU1 SNRP70 U1AP1;None;SFRS10;SRM160;KIAA0324 SRL300 SRM300
1287	HNRPF-HNRPH1 complex	Human	None	None	P31943;P52597	3187;3185	MI:0019-coimmunoprecipitation	GO:0008380;GO:0003723;GO:0005634	RNA splicing;RNA binding;nucleus	11.04.03.01;16.03.03;70.10	splicing;RNA binding;nucleus	9858532	The complex is involved in alternative splicing.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein F	HNRNPH1;HNRNPF	HNRPH HNRPH1;HNRPF
1288	DCS complex (PTBP1, PTBP2, HNRPH1, HNRPF)	Human	None	None	P26599;P31943;P52597;Q9UKA9	5725;3187;3185;58155	MI:0004-affinity chromatography technology;MI:0019-coimmunoprecipitation;MI:0226-ion exchange chromatography	GO:0043484;GO:0048024;GO:0003723;GO:0005634	regulation of RNA splicing;regulation of mRNA splicing, via spliceosome;RNA binding;nucleus	11.04.03.01.10;16.03.03;70.10	regulation of splicing;RNA binding;nucleus	11003644	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Polypyrimidine tract-binding protein 1;Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein F;Polypyrimidine tract-binding protein 2	PTBP1;HNRNPH1;HNRNPF;PTBP2	PTB;HNRPH HNRPH1;HNRPF;NPTB PTB PTBLP
1293	IPO13-RBM8A-MAGOH complex	Human	None	None	O94829;P61326;Q9Y5S9	9670;4116;9939	MI:0004-affinity chromatography technology	GO:0050658;GO:0051033;GO:0051169;GO:0005634	RNA transport;RNA transmembrane transporter activity;nuclear transport;nucleus	20.01.21;20.09.01;70.10	RNA transport;nuclear transport;nucleus	11447110	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Importin-13;Protein mago nashi homolog;RNA-binding protein 8A	IPO13;MAGOH;RBM8A	KIAA0724 RANBP13;MAGOHA;RBM8
1296	DCP1A-DCP2 Decapping complex	Human	None	None	Q8IU60;Q9NPI6	167227;55802	MI:0019-coimmunoprecipitation	GO:0006401;GO:0005737	RNA catabolic process;cytoplasm	01.03.16.01;70.03	RNA degradation;cytoplasm	12417715	Although the authors suggest the existence of a protein complex containing DCP proteins and UPF proteins they also state that there is currently no direct evidence for the significance of a strong interaction between hUpf1 and hDcp proteins.	None	None	Homo sapiens (Human);Homo sapiens (Human)	m7GpppN-mRNA hydrolase;mRNA-decapping enzyme 1A	DCP2;DCP1A	NUDT20;SMIF
1297	MKK4-ARRB2-ASK1 complex	Human	None	None	P32121;P45985;Q99683	409;6416;4217	MI:0019-coimmunoprecipitation	GO:0007254;GO:0000165	JNK cascade;MAPK cascade	30.01.05.01.02;30.01.05.01.03	JNK cascade;MAPKKK cascade	11090355	The data suggest that ASK1 binds directly to beta -arrestin 2, and MKK4 interacts indirectly with beta -arrestin 2 via ASK1 or JNK3, thus forming a complete MAPK module.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Beta-arrestin-2;Dual specificity mitogen-activated protein kinase kinase 4;Mitogen-activated protein kinase kinase kinase 5	ARRB2;MAP2K4;MAP3K5	ARB2 ARR2;JNKK1 MEK4 MKK4 PRKMK4 SEK1 SERK1 SKK1;ASK1 MAPKKK5 MEKK5
1298	MKK4-ARRB2-JNK3 complex	Human	None	None	P32121;P45985;P53779	409;6416;5602	MI:0019-coimmunoprecipitation	GO:0007254;GO:0000165	JNK cascade;MAPK cascade	30.01.05.01.02;30.01.05.01.03	JNK cascade;MAPKKK cascade	11090355	The data suggest that ASK1 binds directly to beta -arrestin 2, and MKK4 interacts indirectly with beta -arrestin 2 via ASK1 or JNK3, thus forming a complete MAPK module.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Beta-arrestin-2;Dual specificity mitogen-activated protein kinase kinase 4;Mitogen-activated protein kinase 10	ARRB2;MAP2K4;MAPK10	ARB2 ARR2;JNKK1 MEK4 MKK4 PRKMK4 SEK1 SERK1 SKK1;JNK3 JNK3A PRKM10 SAPK1B
1299	POSH-MLK3 complex	Human	None	None	Q16584;Q7Z6J0	4296;57630	MI:0019-coimmunoprecipitation	GO:0007254	JNK cascade	30.01.05.01.02	JNK cascade	14504284	A POSH mutant unable to bind to Akt2 exhibits increased binding to MLK3. This increased binding of MLK3 to POSH is accompanied by increased activation of the JNK signaling pathway.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Mitogen-activated protein kinase kinase kinase 11;E3 ubiquitin-protein ligase SH3RF1	MAP3K11;SH3RF1	MLK3 PTK1 SPRK;KIAA1494 POSH POSH1 RNF142 SH3MD2
1300	CRLR-RAMP1 complex	Human	None	HEK 293T cells	O60894;Q16602	10267;10203	MI:0019-coimmunoprecipitation	GO:0007186;GO:0005886	G protein-coupled receptor signaling pathway;plasma membrane	30.05.02.24;70.02	G-protein coupled receptor signalling pathway;eukaryotic plasma membrane / membrane attached	11387328	The results demonstrate that RAMP2 and RAMP3 and not only RAMP1 can promote the full maturation of CRLR, leading to its terminal glycosylation, and only the fully processed receptors were found to bind AM (adrenomedullin) and CGRP (calcitonin gene-related peptide).	None	None	Homo sapiens (Human);Homo sapiens (Human)	Receptor activity-modifying protein 1;Calcitonin gene-related peptide type 1 receptor	RAMP1;CALCRL	None;CGRPR
1301	CRLR-RAMP1 complex	Human	None	HEK 293T cells	O60894;Q16602	10267;10203	MI:0019-coimmunoprecipitation;MI:0054-fluorescence-activated cell sorting	GO:0007186;GO:0005886	G protein-coupled receptor signaling pathway;plasma membrane	30.05.02.24;70.02	G-protein coupled receptor signalling pathway;eukaryotic plasma membrane / membrane attached	11535606	When RAMP1 is expressed with CRLR, it is targeted to the cell surface as a heterodimer. CGRP (calcitonin gene-related peptide) binding and receptor activation lead to the phosphorylation of CRLR and the internalization of the receptor as a stable complex.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Receptor activity-modifying protein 1;Calcitonin gene-related peptide type 1 receptor	RAMP1;CALCRL	None;CGRPR
1306	HNRNPD (p45)-PIN1 complex	Human	AUF1 (p45)-PIN1 complex	human peripheral blood	Q13526;Q14103-1	5300;3184	MI:0019-coimmunoprecipitation	GO:0005125;GO:0005737;GO:0032604	cytokine activity;cytoplasm;granulocyte macrophage colony-stimulating factor production	40.02.03.01;70.03	cytokines (interleukines, colony stimulating factors, etc.);cytoplasm	16273101	Immunoprecipitation of eosinophil cytoplasmic lysates demonstrated an interaction between Pin1 and all four AUF1 isoforms. The data indicate that Pin1 is a critical regulator of cytokine mRNA turnover, which in turn controls the survival of activated eosinophils in the lungs of asthmatics. In addition, because AUF1 controls the decay of many other ARE mRNAs, Pin1 may be important in cytokine production by other activated cells as well.	None	Pin1 is a key mediator of GM-CSF production and activated in vivo after allergen challenge. AUF1 / HNRNPD contains 4 isoforms/splice variants (isoform1=p45=Dx9=355aa, isoform2=p42=Dx4=336aa, isoform3=p40=Dx7=306aa, isoform4=p37=287aa).	Homo sapiens (Human);Homo sapiens (Human)	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1;Isoform 1 of Heterogeneous nuclear ribonucleoprotein D0	PIN1;HNRNPD	None;AUF1 HNRPD
1307	Multiprotein bridging complex (translationally coupled mRNA turnover)	Human	None	HeLa cytoplasmic lysate	O60506;O75534;P11940;Q14103;Q9H074	10492;7812;26986;3184;10605	MI:0019-coimmunoprecipitation;MI:0029-cosedimentation through density gradient;MI:0047-far western blotting	GO:0006401;GO:0005737	RNA catabolic process;cytoplasm	01.03.16.01;70.03	RNA degradation;cytoplasm	11051545	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Heterogeneous nuclear ribonucleoprotein Q;Cold shock domain-containing protein E1;Polyadenylate-binding protein 1;Heterogeneous nuclear ribonucleoprotein D0;Polyadenylate-binding protein-interacting protein 1	SYNCRIP;CSDE1;PABPC1;HNRNPD;PAIP1	HNRPQ NSAP1;D1S155E KIAA0885 NRU UNR;PAB1 PABP PABP1 PABPC2;AUF1 HNRPD;None
1308	EIF4G1-HSP70-HSPA8-HNRNPD-PABPC1 complex	Human	None	HeLa cells	P11142;P11940;Q04637;Q14103;Q59EJ3	3312;26986;1981;3184;3303	MI:0019-coimmunoprecipitation	GO:0006401	RNA catabolic process	01.03.16.01	RNA degradation	10205060	Cytokine and proto-oncogene messenger RNAs (mRNAs) are rapidly degraded through AU-rich elements in the 39 untranslated region. Rapid decay involves AU-rich binding protein AUF1, which complexes with heat shock proteins hsc70-hsp70, translation initiation factor eIF4G, and poly(A) binding protein PABP.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Heat shock cognate 71 kDa protein;Polyadenylate-binding protein 1;Eukaryotic translation initiation factor 4 gamma 1;Heterogeneous nuclear ribonucleoprotein D0;Heat shock 70kDa protein 1A variant	HSPA8;PABPC1;EIF4G1;HNRNPD;None	HSC70 HSP73 HSPA10;PAB1 PABP PABP1 PABPC2;EIF4F EIF4G EIF4GI;AUF1 HNRPD;None
1317	ATF7-TAF12 complex	Human	None	None	P17544;Q16514	11016;6883	MI:0019-coimmunoprecipitation	GO:0045893	positive regulation of DNA-templated transcription	11.02.03.04.01	transcription activation	15735663	The overexpression of hsTAF12 potentiates ATF7-induced transcriptional activation through direct interaction with ATF7, suggesting that TAF12 is a functional partner of ATF7. Although both TAF12 isoforms (TAF12-1 and -2, formerly TAF(II)20 and TAF(II)15) interact with the ATF7 activation region through their histone-fold domain, only the largest, hsTAF12-1, mediates transcriptional activation through its N-terminal region.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cyclic AMP-dependent transcription factor ATF-7;Transcription initiation factor TFIID subunit 12	ATF7;TAF12	ATFA;TAF15 TAF2J TAFII20
1318	Transcription initiation factor complex (TAF1, TAF5, TAF11, TAF12, TBP)	Human	None	HeLa cells	P20226;P21675;Q15542;Q15544;Q16514	6908;6872;6877;6882;6883	MI:0019-coimmunoprecipitation;MI:0047-far western blotting	GO:0006352	DNA-templated transcription initiation	11.02.03.01.01	transcription initiation	9045704	Human transcription initiation factor TFIID contains the TATA-binding protein (TBP) and several TBP-associated factors (TAFs). The authors suggest that hTAFII100 may help stabilize interactions of the histone-like TAFs perhaps within an octamer structure.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	TATA-box-binding protein;Transcription initiation factor TFIID subunit 1;Transcription initiation factor TFIID subunit 5;Transcription initiation factor TFIID subunit 11;Transcription initiation factor TFIID subunit 12	TBP;TAF1;TAF5;TAF11;TAF12	GTF2D1 TF2D TFIID;BA2R CCG1 CCGS TAF2A;TAF2D;TAF2I;TAF15 TAF2J TAFII20
1321	Transcription initiation factor complex (TAF5, TAF6, TAF9, TAF11, TBP)	Human	None	HeLa cells	P20226;P49848;Q15542;Q15544;Q16594	6908;6878;6877;6882;6880	MI:0019-coimmunoprecipitation;MI:0047-far western blotting;MI:0400-affinity technology	GO:0006352	DNA-templated transcription initiation	11.02.03.01.01	transcription initiation	9045704	Human transcription initiation factor TFIID contains the TATA-binding protein (TBP) and several TBP-associated factors (TAFs). The authors suggest that hTAFII100 may help stabilize interactions of the histone-likeTAFs, perhaps within an octamer structure.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	TATA-box-binding protein;Transcription initiation factor TFIID subunit 6;Transcription initiation factor TFIID subunit 5;Transcription initiation factor TFIID subunit 11;Transcription initiation factor TFIID subunit 9	TBP;TAF6;TAF5;TAF11;TAF9	GTF2D1 TF2D TFIID;TAF2E TAFII70;TAF2D;TAF2I;TAF2G TAFII31
1332	Large Drosha complex	Human	None	None	O00571;O14979;O43143;P17844;P31943;P35637;P52272;Q00839;Q01844;Q12905;Q12906;Q13148;Q8WYQ5;Q92499;Q92804;Q92841;Q96SB4;Q9BUJ2;Q9NRR4;Q9UKM9	1654;9987;1665;1655;3187;2521;4670;3192;2130;3608;3609;23435;54487;1653;8148;10521;6732;11100;29102;22913	MI:0007-anti tag coimmunoprecipitation;MI:0071-molecular sieving	GO:0006396;GO:0003723;GO:0005634	RNA processing;RNA binding;nucleus	11.04;16.03.03;70.10	RNA processing;RNA binding;nucleus	15531877	The large Drosha complex shows only weak pri-miRNA processing activity. It might be involved in pri-ribosomal RNA processing.	DGCR8 is deleted in DiGeorge syndrome. EWS is involved in Ewing's sarcoma disease.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	ATP-dependent RNA helicase DDX3X;Heterogeneous nuclear ribonucleoprotein D-like;ATP-dependent RNA helicase DHX15;Probable ATP-dependent RNA helicase DDX5;Heterogeneous nuclear ribonucleoprotein H;RNA-binding protein FUS;Heterogeneous nuclear ribonucleoprotein M;Heterogeneous nuclear ribonucleoprotein U;RNA-binding protein EWS;Interleukin enhancer-binding factor 2;Interleukin enhancer-binding factor 3;TAR DNA-binding protein 43;Microprocessor complex subunit DGCR8;ATP-dependent RNA helicase DDX1;TATA-binding protein-associated factor 2N;Probable ATP-dependent RNA helicase DDX17;SRSF protein kinase 1;Heterogeneous nuclear ribonucleoprotein U-like protein 1;Ribonuclease 3;RNA-binding protein Raly	DDX3X;HNRNPDL;DHX15;DDX5;HNRNPH1;FUS;HNRNPM;HNRNPU;EWSR1;ILF2;ILF3;TARDBP;DGCR8;DDX1;TAF15;DDX17;SRPK1;HNRNPUL1;DROSHA;RALY	DBX DDX3;HNRPDL JKTBP;DBP1 DDX15;G17P1 HELR HLR1;HNRPH HNRPH1;TLS;HNRPM NAGR1;C1orf199 HNRPU SAFA U21.1;EWS;NF45;DRBF MPHOSPH4 NF90;TDP43;C22orf12 DGCRK6;None;RBP56 TAF2N;None;None;E1BAP5 HNRPUL1;RN3 RNASE3L RNASEN;HNRPCL2 P542
1335	SNW1 complex	Human	None	None	O75643;O95071;P07437;P11021;P17858;P23246;P26641;P43243;P43246;P68104;Q00839;Q13573;Q15029;Q16531;Q6P2Q9;Q99459;Q9BUQ8;Q9UG63	23020;51366;203068;3309;5211;6421;1937;9782;4436;1915;3192;22938;9343;1642;10594;988;9416;10061	MI:0007-anti tag coimmunoprecipitation	GO:0045893;GO:0008380;GO:0005634	positive regulation of DNA-templated transcription;RNA splicing;nucleus	11.02.03.04.01;11.04.03.01;70.10	transcription activation;splicing;nucleus	12840015	Identified subunits of the SNW1 complex represent components of the spliceosome as well as other nuclear matrix-associated proteins. Evidence was found that the complex couples vitamin D receptor-mediated transcription and RNA splicing.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	U5 small nuclear ribonucleoprotein 200 kDa helicase;E3 ubiquitin-protein ligase UBR5;Tubulin beta chain;Endoplasmic reticulum chaperone BiP;ATP-dependent 6-phosphofructokinase, liver type;Splicing factor, proline- and glutamine-rich;Elongation factor 1-gamma;Matrin-3;DNA mismatch repair protein Msh2;Elongation factor 1-alpha 1;Heterogeneous nuclear ribonucleoprotein U;SNW domain-containing protein 1;116 kDa U5 small nuclear ribonucleoprotein component;DNA damage-binding protein 1;Pre-mRNA-processing-splicing factor 8;Cell division cycle 5-like protein;Probable ATP-dependent RNA helicase DDX23;ATP-binding cassette sub-family F member 2	SNRNP200;UBR5;TUBB;HSPA5;PFKL;SFPQ;EEF1G;MATR3;MSH2;EEF1A1;HNRNPU;SNW1;EFTUD2;DDB1;PRPF8;CDC5L;DDX23;ABCF2	ASCC3L1 HELIC2 KIAA0788;EDD EDD1 HYD KIAA0896;TUBB5;GRP78;None;PSF;EF1G;KIAA0723;None;EEF1A EF1A LENG7;C1orf199 HNRPU SAFA U21.1;SKIIP SKIP;KIAA0031 SNRP116;XAP1;PRPC8;KIAA0432 PCDC5RP;None;None
1338	FOXO3-PCAF complex, oxidative stress stimulated	Human	None	None	O43524;Q92831	2309;8850	MI:0007-anti tag coimmunoprecipitation	GO:2001141;GO:0006355;GO:0000302;GO:0006979;GO:0005634	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;response to reactive oxygen species;response to oxidative stress;nucleus	11.02.03.04;32.01.01;70.10	transcriptional control;oxidative stress response;nucleus	14976264	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Forkhead box protein O3;Histone acetyltransferase KAT2B	FOXO3;KAT2B	FKHRL1, FOXO3A;PCAF
1347	NPC subcomplex (NUP96, NUP107, NUP133, NUP160)	Human	None	HeLa cells	P52948;P57740;Q12769;Q8WUM0	4928;57122;23279;55746	MI:0018-two hybrid;MI:0019-coimmunoprecipitation;MI:0027-cosedimentation;MI:0051-fluorescence technology	GO:0000278;GO:0015031;GO:0006810;GO:0051169;GO:0000775;GO:0005643	mitotic cell cycle;protein transport;transport;nuclear transport;chromosome, centromeric region;nuclear pore	10.03.01.01;20.01.10;20;20.09.01;70.10.04	mitotic cell cycle;protein transport;CELLULAR TRANSPORT, TRANSPORT FACILITIES AND TRANSPORT ROUTES;nuclear transport;centromere / kinetochore	11564755	hNup133 and hNup107 are part of a NPC subcomplex that contains two other nucleoporins: the previously characterized hNup96 and a novel nucleoporin designated as hNup120.	None	Nuclear pore complex protein NUP98-NUP96 is cleaved into two chains: 98 kDa nucleoporin NUP98 and 96 kDa nucleoporin NUP96. Here NUP96 was found in the complex.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup107;Nuclear pore complex protein Nup160;Nuclear pore complex protein Nup133	NUP98;NUP107;NUP160;NUP133	ADAR2;None;KIAA0197 NUP120;None
1348	GLE1-NUPL2-NUP155 complex	Human	None	None	O15504;O75694;Q53GS7	11097;9631;2733	MI:0004-affinity chromatography technology	GO:0006886;GO:0006605;GO:0015031	intracellular protein transport;protein targeting;protein transport	14.04;20.01.10	protein targeting, sorting and translocation;protein transport	16000379	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Nucleoporin NUP42;Nuclear pore complex protein Nup155;mRNA export factor GLE1	NUP42;NUP155;GLE1	CG1 NUPL2;KIAA0791;GLE1L
1352	ING4 complex (ING4, JADE1, KAT7, MEAF6)	Human	ING4 complex (ING4, PHF17, HBO1, C1orf149)	HeLa S3 cells	O95251;Q6IE81;Q9HAF1;Q9UNL4	11143;79960;64769;51147	MI:0004-affinity chromatography technology;MI:0069-mass spectrometry studies of complexes	GO:0000278;GO:0051726;GO:0001525	mitotic cell cycle;regulation of cell cycle;angiogenesis	10.03.01.01;10.03.01;41.05.16	mitotic cell cycle;mitotic cell cycle and cell cycle control;angiogenesis	16387653	ING4 associates with the HBO1 HAT required for normal progression through S phase and the majority of histone H4 acetylation in vivo. ING subunits are probably crucial for acetylation of chromatin substrates.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone acetyltransferase KAT7;Protein Jade-1;Chromatin modification-related protein MEAF6;Inhibitor of growth protein 4	KAT7;JADE1;MEAF6;ING4	HBO1 HBOa MYST2;KIAA1807 PHF17;C1orf149 CENP-28 EAF6;None
1372	Rb-tal-1-E2A-Lmo2-Ldb1 complex	Human	None	None	P06400;P15923;P17542;P25791;Q86U70	5925;6929;6886;4005;8861	MI:0019-coimmunoprecipitation	GO:0045892;GO:0030218;GO:0005634	negative regulation of DNA-templated transcription;erythrocyte differentiation;nucleus	11.02.03.04.03;43.03.07;70.10	transcription repression;blood cell;nucleus	10866689	Data indicate that this pentameric complex assembled in maturing erythroblasts plays an important regulatory role in c-kit downmodulation; hypothetically, the complex may regulate the expression of other critical erythroid genes.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Retinoblastoma-associated protein;Transcription factor E2-alpha;T-cell acute lymphocytic leukemia protein 1;Rhombotin-2;LIM domain-binding protein 1	RB1;TCF3;TAL1;LMO2;LDB1	None;BHLHB21 E2A ITF1;BHLHA17 SCL TCL5;RBTN2 RBTNL1 RHOM2 TTG2;CLIM2
1377	hASC-1 complex	Human	None	None	Q15650;Q8N3C0;Q8N9N2;Q9H1I8	9325;10973;51008;84164	MI:0029-cosedimentation through density gradient	GO:0045893;GO:0023052;GO:0005634	positive regulation of DNA-templated transcription;signaling;nucleus	11.02.03.04.01;30.01;70.10	transcription activation;cellular signalling;nucleus	12077347	Endogenous hASC-1 complex appears to play an essential role in AP-1, SRF, and NF-kappaB transactivation and to mediate the transrepression between nuclear receptors and either AP-1 or NF-kappaB in vivo.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Activating signal cointegrator 1;Activating signal cointegrator 1 complex subunit 3;Activating signal cointegrator 1 complex subunit 1;Activating signal cointegrator 1 complex subunit 2	TRIP4;ASCC3;ASCC1;ASCC2	RQT4;HELIC1 RQT2;None;ASC1P100 RQT3
1379	GALNS-lysosomal hydrolase 1.27 MDa complex	Human	CTSA-GALNS-GLB1-NEU1 complex; GALNS - beta-galactosidase - alpha-neuraminidase - cathepsin A complex	None	P10619;P16278;P34059;Q99519	5476;2720;2588;4758	MI:0006-anti bait coimmunoprecipitation;MI:0029-cosedimentation through density gradient;MI:0071-molecular sieving	GO:0005976;GO:0005764	polysaccharide metabolic process;lysosome	01.05.03;70.25	polysaccharide metabolism;vacuole or lysosome	8910459	The 1.27-MDa complex of lysosomal hydrolases is essential for keratan sulfate catabolism. Disruption of this complex may be responsible for the KS accumulation in beta-galactosidosis and galactosialidosis patients.Association of GALNS with the three other lysosomal hydrolases protects GALNS in lysosomes.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Lysosomal protective protein;Beta-galactosidase;N-acetylgalactosamine-6-sulfatase;Sialidase-1	CTSA;GLB1;GALNS;NEU1	PPGB;ELNR1;None;NANH
1380	Elongator holo complex	Human	None	None	O95163;Q6IA86;Q96EB1;Q9H9T3	8518;55250;26610;55140	MI:0029-cosedimentation through density gradient	GO:0006354;GO:0006473;GO:0006476;GO:0005634	DNA-templated transcription elongation;protein acetylation;protein deacetylation;nucleus	11.02.03.01.04;14.07.04;70.10	transcription elongation;modification by acetylation, deacetylation;nucleus	11714725	The holo-Elongator complex has histone acetyltransferase activity directed against histone H3 and H4. Holo-Elongator interacts with RNA polymerase II.	None	Two other subunits of the complex were found in the analysis, which have not been further characterized: p38, p30.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Elongator complex protein 1;Elongator complex protein 2;Elongator complex protein 4;Elongator complex protein 3	ELP1;ELP2;ELP4;ELP3	IKAP IKBKAP;STATIP1;C11orf19 PAXNEB;None
1386	TTP-AGO4 complex	Human	None	None	P26651;Q9HCK5	7538;192670	MI:0019-coimmunoprecipitation	GO:0006402;GO:0061157	mRNA catabolic process;mRNA destabilization	None	None	15766526	In analogy to the TTP-AGO2 complex the TTP-AGO4 complex is presumably involved in the miRNA-mediated degradation of RNAs containing AU-rich elements (AREs).	None	None	Homo sapiens (Human);Homo sapiens (Human)	mRNA decay activator protein ZFP36;Protein argonaute-4	ZFP36;AGO4	G0S24 NUP475 RNF162A TIS11A TTP;EIF2C4, KIAA1567
1387	TTP-AGO2 complex	Human	None	None	P26651;Q9UKV8	7538;27161	MI:0019-coimmunoprecipitation	GO:0006402;GO:0061157	mRNA catabolic process;mRNA destabilization	None	None	15766526	The TTP-AGO2 complex is involved in the miRNA-mediated degradation of RNAs containing AU-rich elements (AREs).	None	None	Homo sapiens (Human);Homo sapiens (Human)	mRNA decay activator protein ZFP36;Protein argonaute-2	ZFP36;AGO2	G0S24 NUP475 RNF162A TIS11A TTP;EIF2C2
1399	WDR5-ASH2L-RBBP5-MLL2 complex	Human	3 H4 methyltransferase complex	None	O14686;P61964;Q15291;Q9UBL3	8085;11091;5929;9070	MI:0019-coimmunoprecipitation	GO:0045893;GO:0018126;GO:0006479;GO:0005634	positive regulation of DNA-templated transcription;protein hydroxylation;protein methylation;nucleus	11.02.03.04.01;14.07.09;70.10	transcription activation;posttranslational modification of amino acids (e.g. hydroxylation, methylation);nucleus	15960974	The WDR5-ASH2L-RBBP5-MLL2 complex performs methylation of lysine 4 (K4) of histone H3. Knockdown of xWDR5 during Xenopus development leads to somitic, gut, and hematopoetic defects.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone-lysine N-methyltransferase 2D;WD repeat-containing protein 5;Retinoblastoma-binding protein 5;Set1/Ash2 histone methyltransferase complex subunit ASH2	KMT2D;WDR5;RBBP5;ASH2L	ALR MLL2 MLL4;BIG3;RBQ3;ASH2L1
1400	ASCOM complex	Human	ASC-2 complex	None	O14686;P07437;P68366;Q14686;Q15291;Q8NEZ4;Q9UBL3	8085;203068;7277;23054;5929;58508;9070	MI:0006-anti bait coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0006265;GO:0045893;GO:0003677;GO:0051276;GO:0005634	DNA topological change;positive regulation of DNA-templated transcription;DNA binding;chromosome organization;nucleus	10.01.09.05;11.02.03.04.01;16.03.01;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription activation;DNA binding;organization of chromosome structure;nucleus	12482968	ASCOM exhibit very weak but specific H3-lysine 4 methylation activities in vitro, and transactivation by retinoic acid receptor appears to involve ligand-dependent recruitment of ASCOM and subsequent transient H3-lysine 4 methylation of the promoter region in vivo. Thus, ASCOM may represent a distinct coactivator complex of nuclear receptors. MALDI-TOF mass spectrometry analyses identified also ALR-2, the splicing isoform of ALR-1.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone-lysine N-methyltransferase 2D;Tubulin beta chain;Tubulin alpha-4A chain;Nuclear receptor coactivator 6;Retinoblastoma-binding protein 5;Histone-lysine N-methyltransferase 2C;Set1/Ash2 histone methyltransferase complex subunit ASH2	KMT2D;TUBB;TUBA4A;NCOA6;RBBP5;KMT2C;ASH2L	ALR MLL2 MLL4;TUBB5;TUBA1;AIB3 KIAA0181 RAP250 TRBP;RBQ3;HALR, KIAA1506, MLL3;ASH2L1
1401	MOF complex	Human	None	None	O14686;O15047;P21675;P49848;P61964;Q03164;Q15291;Q16594;Q99496;Q9H7Z6	8085;9739;6872;6878;11091;4297;5929;6880;6045;84148	MI:0007-anti tag coimmunoprecipitation;MI:0226-ion exchange chromatography	GO:0005634	nucleus	70.10	nucleus	15960975	None	None	Immunoprecipitation of the three step purified complex by anti-MOF antibodies. The complex was not functionally characterized.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone-lysine N-methyltransferase 2D;Histone-lysine N-methyltransferase SETD1A;Transcription initiation factor TFIID subunit 1;Transcription initiation factor TFIID subunit 6;WD repeat-containing protein 5;Histone-lysine N-methyltransferase 2A;Retinoblastoma-binding protein 5;Transcription initiation factor TFIID subunit 9;E3 ubiquitin-protein ligase RING2;Histone acetyltransferase KAT8	KMT2D;SETD1A;TAF1;TAF6;WDR5;KMT2A;RBBP5;TAF9;RNF2;KAT8	ALR MLL2 MLL4;KIAA0339 KMT2F SET1 SET1A;BA2R CCG1 CCGS TAF2A;TAF2E TAFII70;BIG3;ALL1 CXXC7 HRX HTRX MLL MLL1 TRX1;RBQ3;TAF2G TAFII31;BAP1 DING HIPI3 RING1B;MOF MYST1
1413	NCOR1 complex	Human	None	None	O15379;O75376;P51532;Q12824;Q13263;Q15393;Q15459;Q6ZRS2;Q8TAQ2;Q92922	8841;9611;6597;6598;10155;23450;10291;10847;6601;6599	MI:0004-affinity chromatography technology;MI:0029-cosedimentation through density gradient;MI:0071-molecular sieving	GO:0006265;GO:0045892;GO:0032774;GO:0006476;GO:0051276;GO:0005634	DNA topological change;negative regulation of DNA-templated transcription;RNA biosynthetic process;protein deacetylation;chromosome organization;nucleus	10.01.09.05;11.02.03.04.03;11.02;14.07.04;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription repression;RNA synthesis;modification by acetylation, deacetylation;organization of chromosome structure;nucleus	11013263	Transcriptional silencing by many transcription factors is mediated by the nuclear receptor corepressor (N-CoR). The mechanism by which N-CoR represses basal transcription involves the direct or indirect recruitment of histone deacetylases (HDACs). Two multiprotein N-CoR complexes have been isolated, designated N-CoR-1 and N-CoR-2, which possess histone deacetylase activity that is mediated by distinct HDACs. Results suggest that N-CoR is found in distinct multiprotein complexes, which are involved in multiple pathways of transcriptional repression.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone deacetylase 3;Nuclear receptor corepressor 1;Transcription activator BRG1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1;Transcription intermediary factor 1-beta;Splicing factor 3B subunit 3;Splicing factor 3A subunit 1;Helicase SRCAP;SWI/SNF complex subunit SMARCC2;SWI/SNF complex subunit SMARCC1	HDAC3;NCOR1;SMARCA4;SMARCB1;TRIM28;SF3B3;SF3A1;SRCAP;SMARCC2;SMARCC1	None;KIAA1047;BAF190A BRG1 SNF2B SNF2L4;BAF47, INI1, SNF5L1;KAP1 RNF96 TIF1B;KIAA0017 SAP130;SAP114;KIAA0309;BAF170;BAF155
1439	PTGS2 homodimer complex	Human	None	None	P35354	5743	MI:0114-x-ray crystallography	GO:0006720;GO:0006633;GO:0008299;GO:0009062;GO:0016042;GO:0008300;GO:0006629;GO:0006631;GO:0008610	isoprenoid metabolic process;fatty acid biosynthetic process;isoprenoid biosynthetic process;fatty acid catabolic process;lipid catabolic process;isoprenoid catabolic process;lipid metabolic process;fatty acid metabolic process;lipid biosynthetic process	01.06;01.06.05;01.06.06	lipid, fatty acid and isoprenoid metabolism;fatty acid metabolism;isoprenoid metabolism	10811226	None	None	None	Homo sapiens (Human)	Prostaglandin G/H synthase 2	PTGS2	COX2
1448	LIN2-LIN7-SAP97 complex	Human	None	HEK 293 cells, MDCK cells, epithelium	O14910;O14936;Q12959	8825;8573;1739	MI:0019-coimmunoprecipitation	GO:0006886;GO:0006605;GO:0015031;GO:0051211;GO:0009798;GO:0030855;GO:0002009	intracellular protein transport;protein targeting;protein transport;anisotropic cell growth;axis specification;epithelial cell differentiation;morphogenesis of an epithelium	14.04;20.01.10;40.01.03;41.05.19;45.03.09	protein targeting, sorting and translocation;protein transport;directional cell growth (morphogenesis);asymmetries and axis determination;epithelium	11865057	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein lin-7 homolog A;Peripheral plasma membrane protein CASK;Disks large homolog 1	LIN7A;CASK;DLG1	MALS1 VELI1;LIN2;None
1452	MCM2-MCM6-MCM7 complex	Human	None	None	P33993;P49736;Q14566	4176;4171;4175	MI:0006-anti bait coimmunoprecipitation	GO:0006260;GO:0005634	DNA replication;nucleus	10.01.03;70.10	DNA synthesis and replication;nucleus	15448696	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA replication licensing factor MCM7;DNA replication licensing factor MCM2;DNA replication licensing factor MCM6	MCM7;MCM2;MCM6	CDC47 MCM2;BM28 CCNL1 CDCL1 KIAA0030;None
1457	AFF1-MLLT1-CBX8 complex	Human	None	None	P51825;Q03111;Q9HC52	4299;4298;57332	MI:0027-cosedimentation	GO:2001141;GO:0006355;GO:0016607	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;nuclear speck	11.02.03.04;70.10.09	transcriptional control;nuclear speckles	15856011	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	AF4/FMR2 family member 1;Protein ENL;Chromobox protein homolog 8	AFF1;MLLT1;CBX8	AF4 FEL MLLT2 PBM1;ENL LTG19 YEATS1;PC3 RC1
1458	SNF2h-HDAC12 complex	Human	None	None	O60264;Q92769	8467;3066	MI:0019-coimmunoprecipitation	GO:0051052;GO:0006473;GO:0006476;GO:0051276	regulation of DNA metabolic process;protein acetylation;protein deacetylation;chromosome organization	10.01.11;14.07.04;42.10.03	regulation of DNA processing;modification by acetylation, deacetylation;organization of chromosome structure	15775975	SNF2h-HDAC1/2 complex coordinates G1-specific chromatin remodeling and histone deacetylation with the DNA replication initiation process at OriP.	None	None	Homo sapiens (Human);Homo sapiens (Human)	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5;Histone deacetylase 2	SMARCA5;HDAC2	SNF2H, WCRF135;None
1462	hPRC1L complex	Human	human Polycomb repressive complex 1-like	None	P35226;Q06587;Q8IXK0;Q99496	648;6015;1912;6045	MI:0071-molecular sieving;MI:0226-ion exchange chromatography	GO:0006304;GO:0009307;GO:0032774;GO:0016567;GO:0005634	DNA modification;DNA restriction-modification system;RNA biosynthetic process;protein ubiquitination;nucleus	10.01.09;11.02;14.07.05;70.10	DNA restriction or modification;RNA synthesis;modification by ubiquitination, deubiquitination;nucleus	15386022	The hPRC1L complex silences transcription by ubiquinating histone H2A at Lys 119.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Polycomb complex protein BMI-1;E3 ubiquitin-protein ligase RING1;Polyhomeotic-like protein 2;E3 ubiquitin-protein ligase RING2	BMI1;RING1;PHC2;RNF2	PCGF4 RNF51;RNF1;EDR2 PH2;BAP1 DING HIPI3 RING1B
1464	Mis12 centromere complex	Human	None	None	O95229;P45973;Q6P1K2;Q96IY1;Q9H081;Q9H410	11130;23468;11243;25936;79003;79980	MI:0019-coimmunoprecipitation	GO:0007059;GO:0000775	chromosome segregation;chromosome, centromeric region	10.03.04.05;70.10.04	chromosome segregation/division;centromere / kinetochore	15502821	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	ZW10 interactor;Chromobox protein homolog 5;Polyamine-modulated factor 1;Kinetochore-associated protein NSL1 homolog;Protein MIS12 homolog;Kinetochore-associated protein DSN1 homolog	ZWINT;CBX5;PMF1;NSL1;MIS12;DSN1	None;HP1A;None;C1orf48;None;C20orf172 MIS13
1473	E2F5-RBL2-TFDP1 complex	Human	E2F5-DP1-P130 complex	U2-OS cell line	Q08999;Q14186;Q15329	5934;7027;1875	MI:0018-two hybrid;MI:0019-coimmunoprecipitation;MI:0412-electrophoretic mobility supershift assay;MI:0428-imaging technique	GO:0035189;GO:0007049;GO:0003677;GO:0003700;GO:0008134	Rb-E2F complex;cell cycle;DNA binding;DNA-binding transcription factor activity;transcription factor binding	10.03;16.03.01	cell cycle;DNA binding	7760804	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Retinoblastoma-like protein 2;Transcription factor Dp-1;Transcription factor E2F5	RBL2;TFDP1;E2F5	RB2;DP1;None
1474	SMAD3/4-E2F4/5-p107-DP1 complex	Human	None	None	P28749;P84022;Q13485;Q14186;Q15329;Q16254	5933;4088;4089;7027;1875;1874	MI:0007-anti tag coimmunoprecipitation;MI:0402-chromatin immunoprecipitation assay	GO:0045892;GO:0003677;GO:0007179;GO:0005634	negative regulation of DNA-templated transcription;DNA binding;transforming growth factor beta receptor signaling pathway;nucleus	11.02.03.04.03;16.03.01;30.05.01.18.01;70.10	transcription repression;DNA binding;TGF-beta-receptor signalling pathway;nucleus	12150994	E2F4/5 and p107 act as signal cotransducers that enable a SMAD complex to recognize and repress c-Myc transcription.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Retinoblastoma-like protein 1;Mothers against decapentaplegic homolog 3;Mothers against decapentaplegic homolog 4;Transcription factor Dp-1;Transcription factor E2F5;Transcription factor E2F4	RBL1;SMAD3;SMAD4;TFDP1;E2F5;E2F4	None;MADH3;DPC4 MADH4;DP1;None;None
1488	DNMT1-RB1-HDAC1-E2F1 complex	Human	None	None	P06400;P26358;Q01094;Q13547	5925;1786;1869;3065	MI:0027-cosedimentation	GO:0045892	negative regulation of DNA-templated transcription	11.02.03.04.03	transcription repression	10888886	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Retinoblastoma-associated protein;DNA;Transcription factor E2F1;Histone deacetylase 1	RB1;DNMT1;E2F1;HDAC1	None;AIM CXXC9 DNMT;RBBP3;RPD3L1
1490	DAXX-DNMT1-DMAP1 complex	Human	None	None	P26358;Q9NPF5;Q9UER7	1786;55929;1616	MI:0019-coimmunoprecipitation	GO:0045892	negative regulation of DNA-templated transcription	11.02.03.04.03	transcription repression	14978102	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA;DNA methyltransferase 1-associated protein 1;Death domain-associated protein 6	DNMT1;DMAP1;DAXX	AIM CXXC9 DNMT;KIAA1425;BING2 DAP6
1491	RGS6-DNMT1-DMAP1 complex	Human	None	None	P26358;P49758;Q9NPF5	1786;9628;55929	MI:0018-two hybrid;MI:0019-coimmunoprecipitation	GO:2001141;GO:0006355	regulation of RNA biosynthetic process;regulation of DNA-templated transcription	11.02.03.04	transcriptional control	14734556	This complex inhibits DMAP1 transcriptional repressor activity.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA;Regulator of G-protein signaling 6;DNA methyltransferase 1-associated protein 1	DNMT1;RGS6;DMAP1	AIM CXXC9 DNMT;None;KIAA1425
1492	BHC110 complex	Human	None	None	O60341;O75362;Q13547;Q14687;Q92618;Q92769;Q96BD5;Q9P0W2;Q9UBW7;Q9UKL0	23028;7764;3065;23199;9658;3066;51317;10362;7750;23186	MI:0019-coimmunoprecipitation	GO:0006265;GO:0006473;GO:0006476;GO:0018126;GO:0006479;GO:0005634	DNA topological change;protein acetylation;protein deacetylation;protein hydroxylation;protein methylation;nucleus	10.01.09.05;14.07.04;14.07.09;70.10	DNA conformation modification (e.g. chromatin);modification by acetylation, deacetylation;posttranslational modification of amino acids (e.g. hydroxylation, methylation);nucleus	16079794	The BHC110 complex performs demethylation of histone H3 lysine 4 (H3K4). The related BHC complex (CORUM ID 636) is recruited by a neuronal silencer, REST (RE1-silencing transcription factor), and mediates the repression of REST-responsive genes. Depletion of the CoREST (RCOR1) subunit of the BHC110 complex and the BHC complex results in de-repression of REST-responsive gene expression and increased methylation of H3K4.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Lysine-specific histone demethylase 1A;Zinc finger protein 217;Histone deacetylase 1;Genetic suppressor element 1;Zinc finger protein 516;Histone deacetylase 2;PHD finger protein 21A;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related;Zinc finger MYM-type protein 2;REST corepressor 1	KDM1A;ZNF217;HDAC1;GSE1;ZNF516;HDAC2;PHF21A;HMG20B;ZMYM2;RCOR1	AOF2 KDM1 KIAA0601 LSD1;ZABC1;RPD3L1;KIAA0182;KIAA0222;None;BHC80 KIAA1696;BRAF35 HMGX2 HMGXB2 SMARCE1R;FIM RAMP ZNF198;KIAA0071 RCOR
1495	PID complex	Human	None	HeLa cells	O94776;O95983;Q09028;Q13547;Q14839	9219;53615;5928;3065;1108	MI:0007-anti tag coimmunoprecipitation	GO:0006473;GO:0006476;GO:0051090;GO:0005634;GO:0036211	protein acetylation;protein deacetylation;regulation of DNA-binding transcription factor activity;nucleus;protein modification process	14.07.04;18.02.09;70.10	modification by acetylation, deacetylation;regulator of transcription factor;nucleus	11099047	PID complex-mediated repression of p53 transactivation functions acts, in part, through deacetylation of p53 at the C terminus. Experiments  show that PID is involved in the regulation of p53-mediated growth arrest and apoptosis.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Metastasis-associated protein MTA2;Methyl-CpG-binding domain protein 3;Histone-binding protein RBBP4;Histone deacetylase 1;Chromodomain-helicase-DNA-binding protein 4	MTA2;MBD3;RBBP4;HDAC1;CHD4	MTA1L1 PID;None;RBAP48;RPD3L1;None
1505	NCOR2 complex	Human	None	None	O15379;O75376;O75446;Q13547;Q92769;Q96ST3;Q9Y618	8841;9611;8819;3065;3066;25942;9612	MI:0004-affinity chromatography technology;MI:0029-cosedimentation through density gradient;MI:0071-molecular sieving	GO:0006265;GO:0045892;GO:0032774;GO:0006476;GO:0051276;GO:0005634	DNA topological change;negative regulation of DNA-templated transcription;RNA biosynthetic process;protein deacetylation;chromosome organization;nucleus	10.01.09.05;11.02.03.04.03;11.02;14.07.04;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription repression;RNA synthesis;modification by acetylation, deacetylation;organization of chromosome structure;nucleus	11013263	Transcriptional silencing by many transcription factors is mediated by the nuclear receptor corepressor (N-CoR). The mechanism by which N-CoR represses basal transcription involves the direct or indirect recruitment of histone deacetylases (HDACs). Two multiprotein N-CoR complexes have been isolated, designated N-CoR-1 and N-CoR-2, which possess histone deacetylase activity that is mediated by distinct HDACs. Results suggest that N-CoR is found in distinct multiprotein complexes, which are involved in multiple pathways of transcriptional repression. Only weak amounts of HDAC3 could be detected in the N-CoR-2 complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone deacetylase 3;Nuclear receptor corepressor 1;Histone deacetylase complex subunit SAP30;Histone deacetylase 1;Histone deacetylase 2;Paired amphipathic helix protein Sin3a;Nuclear receptor corepressor 2	HDAC3;NCOR1;SAP30;HDAC1;HDAC2;SIN3A;NCOR2	None;KIAA1047;None;RPD3L1;None;None;CTG26
1508	BCL6-ZBTB17 complex	Human	None	None	P41182;Q13105	604;None	MI:0096-pull down	GO:0045892	negative regulation of DNA-templated transcription	11.02.03.04.03	transcription repression	16142238	BCL6 interacted with the transcriptional activator Miz-1 and, via Miz-1, bound to the promoter and suppressed transcription of the cell cycle arrest gene CDKN1A.	None	None	Homo sapiens (Human);Homo sapiens (Human)	B-cell lymphoma 6 protein;Zinc finger and BTB domain-containing protein 17	BCL6;ZBTB17	BCL5 LAZ3 ZBTB27 ZNF51;MIZ1 ZNF151 ZNF60
1514	IL4-IL4R complex	Human	None	None	P05112;P24394	3565;3566	MI:0030-cross-linking study	GO:0005515;GO:0023052	protein binding;signaling	16.01;30.01	protein binding;cellular signalling	8266078	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Interleukin-4;Interleukin-4 receptor subunit alpha	IL4;IL4R	None;IL4RA
1515	IL-2Rgamma/IL-4R receptor-IL-4 complex	Human	IL2RG-IL4-IL4R complex; Interleukin-4R-interleukin-2Rgamma receptor-interleukin-4 complex; IL4-IL4R-IL2RG complex	COS-7 cells	P05112;P24394;P31785	3565;3566;3561	MI:0030-cross-linking study	GO:0042098;GO:0042100;GO:0019221;GO:0035771;GO:0006955	T cell proliferation;B cell proliferation;cytokine-mediated signaling pathway;interleukin-4-mediated signaling pathway;immune response	36.25.16	immune response	8266078	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Interleukin-4;Interleukin-4 receptor subunit alpha;Cytokine receptor common subunit gamma	IL4;IL4R;IL2RG	None;IL4RA;None
1519	IL6ST-PRKCD-STAT3 complex	Human	None	None	P40189;P40763;Q05655	3572;6774;5580	MI:0019-coimmunoprecipitation	GO:0070103	regulation of interleukin-6-mediated signaling pathway	None	None	12361954	PKCdelta  is recruited to the receptor gp130 via Stat3, which not only stabilizes the Stat3 and gp130 receptor interaction, but may also phosphorylate gp130.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Interleukin-6 receptor subunit beta;Signal transducer and activator of transcription 3;Protein kinase C delta type	IL6ST;STAT3;PRKCD	None;APRF;PKCD
1520	STAT3-NLK-MAP3K7 complex	Human	None	None	O43318;P40763;Q9UBE8	6885;6774;None	MI:0019-coimmunoprecipitation	GO:0007165;GO:0005634	signal transduction;nucleus	30;70.10	CELLULAR COMMUNICATION/SIGNAL TRANSDUCTION MECHANISM;nucleus	15764709	The complex is involved in the TAK1-Nemo-like kinase (NLK) pathway.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mitogen-activated protein kinase kinase kinase 7;Signal transducer and activator of transcription 3;Serine/threonine-protein kinase NLK	MAP3K7;STAT3;NLK	TAK1;APRF;LAK1
1521	p300-SMAD1-STAT3 complex	Human	None	COS cells	P40763;Q09472;Q15797	6774;2033;4086	MI:0007-anti tag coimmunoprecipitation	GO:0045893;GO:0007167;GO:0048708	positive regulation of DNA-templated transcription;enzyme-linked receptor protein signaling pathway;astrocyte differentiation	11.02.03.04.01;30.05.01	transcription activation;receptor enzyme mediated signalling	10205054	P300 acts as an adaptor linking SMAD1 and STAT3.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Signal transducer and activator of transcription 3;Histone acetyltransferase p300;Mothers against decapentaplegic homolog 1	STAT3;EP300;SMAD1	APRF;P300;BSP1 MADH1 MADR1
1522	STAT3 homodimer complex	Human	None	None	P40763	6774	MI:0019-coimmunoprecipitation	GO:2001141;GO:0006355;GO:0003677	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;DNA binding	11.02.03.04;16.03.01	transcriptional control;DNA binding	15653507	Lys685 acetylation was critical for Stat3 to form stable dimers required for cytokine-stimulated DNA binding and transcriptional regulation, to enhance transcription of cell growth-related genes, and to promote cell cycle progression in response to treatment with oncostatin M.	None	None	Homo sapiens (Human)	Signal transducer and activator of transcription 3	STAT3	APRF
1530	Girdin homo-oligomer complex	Human	None	None	Q3V6T2	55704	MI:0019-coimmunoprecipitation	GO:0030036;GO:0048870	actin cytoskeleton organization;cell motility	42.04.03	actin cytoskeleton	16139227	Girdin is essential for the integrity of the actin cytoskeleton and cell migration.	None	None	Homo sapiens (Human)	Girdin	CCDC88A	APE GRDN KIAA1212
1539	G protein complex (GNG2, GNB2L1, RAF1)	Human	None	293-T cells	P04049;P59768;P63244	5894;54331;10399	MI:0007-anti tag coimmunoprecipitation;MI:0018-two hybrid	GO:0007186;GO:0004674	G protein-coupled receptor signaling pathway;protein serine/threonine kinase activity	30.05.02.24	G-protein coupled receptor signalling pathway	7782277	Raf-1 is a serine-threonine protein kinase critically positioned in a cascade linking activated growth factor receptors with the nucleus and ultimatively regulating the mitogenic response.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	RAF proto-oncogene serine/threonine-protein kinase;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2;Receptor of activated protein C kinase 1	RAF1;GNG2;RACK1	RAF;None;GNB2L1
1543	PPP2CA-PPP2R1A complex	Human	None	None	P30153;P67775	5518;5515	MI:0019-coimmunoprecipitation	GO:0030234;GO:0050790	enzyme regulator activity;regulation of catalytic activity	18.02.01	enzymatic activity regulation / enzyme regulator	12370081	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform;Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	PPP2R1A;PPP2CA	None;None
1544	PPP2CA-PPP2R1A-PPP2R3A complex	Human	None	None	P30153;P67775;Q06190	5518;5515;5523	MI:0019-coimmunoprecipitation	GO:0030234;GO:0050790	enzyme regulator activity;regulation of catalytic activity	18.02.01	enzymatic activity regulation / enzyme regulator	12506124	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform;Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform;Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha	PPP2R1A;PPP2CA;PPP2R3A	None;None;PPP2R3
1551	IPO13-RAN-EIF1AX complex	Human	None	HeLa cells	O94829;P47813;P62826	9670;1964;5901	MI:0004-affinity chromatography technology	GO:0015031;GO:0051169;GO:0005737;GO:0005634;GO:0140318	protein transport;nuclear transport;cytoplasm;nucleus;protein transporter activity	20.01.10;20.09.01;70.03;70.10	protein transport;nuclear transport;cytoplasm;nucleus	11447110	Imp13 operates differently from typical exportins in that the binding of eIF1A to Imp13 is only regulated indirectly by RanGTP, and the cytoplasmic release of eIF1A from Imp13 is triggered by the loading of import substrates onto Imp13 (PMID:11447110).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Importin-13;Eukaryotic translation initiation factor 1A, X-chromosomal;GTP-binding nuclear protein Ran	IPO13;EIF1AX;RAN	KIAA0724 RANBP13;EIF1A EIF4C;ARA24
1552	TNPO2-RAN-NXF1 complex	Human	None	HeLa cells	O14787;P62826;Q9UBU9	30000;5901;10482	MI:0019-coimmunoprecipitation	GO:0003723;GO:0005737;GO:0005634;GO:0006405	RNA binding;cytoplasm;nucleus;RNA export from nucleus	16.03.03;70.03;70.10	RNA binding;cytoplasm;nucleus	12384575	TNPO2 (Karyopherin beta-2b) participates directly in the export of a large proportion of cellular mRNAs, and TAP connects TNPO2 to the mRNAs to be exported (PMID:12384575).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transportin-2;GTP-binding nuclear protein Ran;Nuclear RNA export factor 1	TNPO2;RAN;NXF1	None;ARA24;TAP
1554	KPNB1-RAN-RANBP1complex	Human	None	Ehrlich ascetics tumor cells	P43487;P62826;Q14974	5902;5901;3837	MI:0007-anti tag coimmunoprecipitation	GO:0015031;GO:0051169;GO:0005737;GO:0140318	protein transport;nuclear transport;cytoplasm;protein transporter activity	20.01.10;20.09.01;70.03	protein transport;nuclear transport;cytoplasm	10037787	This complex is exported as a complex from the nucleus to the cytoplasm in living cells.The binding of RanBP1 to the Ran-importin beta complex is required for the dissociation of the complex in the cytoplasm and that the released Ran is recycled to the nucleus, which is essential for the nuclear protein transport (PMID:10037787).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Ran-specific GTPase-activating protein;GTP-binding nuclear protein Ran;Importin subunit beta-1	RANBP1;RAN;KPNB1	None;ARA24;NTF97
1557	NMI-POLR1B-RRN3 complex	Human	None	None	Q13287;Q9H9Y6;Q9NYV6	9111;84172;54700	MI:0019-coimmunoprecipitation	GO:0009303	rRNA transcription	11.02.01	rRNA synthesis	15558034	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	N-myc-interactor;DNA-directed RNA polymerase I subunit RPA2;RNA polymerase I-specific transcription initiation factor RRN3	NMI;POLR1B;RRN3	None;None;TIFIA
1558	POLR1B-RRN3 complex	Human	None	None	Q9H9Y6;Q9NYV6	84172;54700	MI:0019-coimmunoprecipitation	GO:0009303	rRNA transcription	11.02.01	rRNA synthesis	15558034	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	DNA-directed RNA polymerase I subunit RPA2;RNA polymerase I-specific transcription initiation factor RRN3	POLR1B;RRN3	None;TIFIA
1559	NMI-RRN3 complex	Human	None	None	Q13287;Q9NYV6	9111;54700	MI:0019-coimmunoprecipitation	GO:0009303	rRNA transcription	11.02.01	rRNA synthesis	15558034	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	N-myc-interactor;RNA polymerase I-specific transcription initiation factor RRN3	NMI;RRN3	None;TIFIA
1561	NMI homodimer complex	Human	None	None	Q13287	9111	MI:0019-coimmunoprecipitation	GO:0065003	protein-containing complex assembly	None	None	11916966	Homodimerization of Nmi enhanced its association with BRCA1.	None	None	Homo sapiens (Human)	N-myc-interactor	NMI	None
1571	Vigilin-DNA-PK-Ku antigen complex	Human	vigilin-Ku70-Ku86-DNA-PKcs complex	None	P12956;P13010;P78527;Q00341	2547;7520;5591;3069	MI:0007-anti tag coimmunoprecipitation	GO:0007059;GO:0006468;GO:0003723;GO:0005694	chromosome segregation;protein phosphorylation;RNA binding;chromosome	10.03.04.05;14.07.03;16.03.03;70.10.03	chromosome segregation/division;modification by phosphorylation, dephosphorylation, autophosphorylation;RNA binding;chromosome	15723802	The authors describe, that in the presence of RNA, the Vigilin complex recruits the DNA-PKcs enzyme, which appears to phosphorylate a discrete set of targets, some or all of which are known to participate in chromatin silencing.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	X-ray repair cross-complementing protein 6;X-ray repair cross-complementing protein 5;DNA-dependent protein kinase catalytic subunit;Vigilin	XRCC6;XRCC5;PRKDC;HDLBP	G22P1;G22P2;HYRC HYRC1;HBP VGL
1612	G protein complex (GNAS, GNB1, GNG2)	Human	Heterotrimeric G protein complex (GNG2, GNB1, GNAS)	HEK293T cells	P59768;P62873;P63092	54331;2782;2778	MI:0012-bioluminescence resonance energy transfer	GO:0005834;GO:0007186	heterotrimeric G-protein complex;G protein-coupled receptor signaling pathway	30.05.02.24	G-protein coupled receptor signalling pathway	15782186	Guanine nucleotide-binding proteins (G proteins) are composed of 3 units, alpha, beta and gamma and are involved in various transmembrane signaling systems.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNG2;GNB1;GNAS	None;None;GNAS1 GSP
1614	G protein complex (GNB1, GNG2, MCF2)	Human	None	HEK293 cells	P10911;P59768;P62873	4168;54331;2782	MI:0019-coimmunoprecipitation;MI:0047-far western blotting	GO:0007186;GO:0005834	G protein-coupled receptor signaling pathway;heterotrimeric G-protein complex	30.05.02.24	G-protein coupled receptor signalling pathway	10518015	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Proto-oncogene DBL;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	MCF2;GNG2;GNB1	DBL;None;None
1615	G protein complex (BTK, GNG1, GNG2)	Human	None	293T cells	P59768;P62873;Q06187	54331;2782;695	MI:0047-far western blotting	GO:0007186;GO:0030154;GO:0005834	G protein-coupled receptor signaling pathway;cell differentiation;heterotrimeric G-protein complex	30.05.02.24;40.02	G-protein coupled receptor signalling pathway;cell differentiation	7972043	None	Deficient expression or function of Bruton tyrosine kinase (Btk) causes human X chromosome-linked agammaglobulinemia (XLA).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;Tyrosine-protein kinase BTK	GNG2;GNB1;BTK	None;None;AGMX1 ATK BPK
1617	G protein complex (CACNA1A, GNB1, GNG2)	Human	None	human erythrocyte membranes	O00555;P59768;P62873	773;54331;2782	MI:0047-far western blotting	GO:0007186	G protein-coupled receptor signaling pathway	30.05.02.24	G-protein coupled receptor signalling pathway	9238069	The direct interaction of the G proteins(beta, gamma) with the Ca-channel alpha 1 subunit is responsible for the channel inhibition by G protein-coupled receptors.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Voltage-dependent P/Q-type calcium channel subunit alpha-1A;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	CACNA1A;GNG2;GNB1	CACH4 CACN3 CACNL1A4;None;None
1618	G protein complex (GNB1, GNG2, PTHR1)	Human	Heterotrimeric complex (GNB1, GNG2, PTHR1)	HEK293 cells	P59768;P62873;Q03431	54331;2782;5745	MI:0047-far western blotting	GO:0007186	G protein-coupled receptor signaling pathway	30.05.02.24	G-protein coupled receptor signalling pathway	16099817	The G protein-coupled receptor for PTH-related protein (PTH1R) signals via many intracellular pathways.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;Parathyroid hormone/parathyroid hormone-related peptide receptor	GNG2;GNB1;PTH1R	None;None;PTHR PTHR1
1619	G protein complex (HDAC5, GNB1, GNG2)	Human	None	HEK293A cells	P59768;P62873;Q9UQL6	54331;2782;10014	MI:0018-two hybrid;MI:0019-coimmunoprecipitation	GO:0045892;GO:0007186	negative regulation of DNA-templated transcription;G protein-coupled receptor signaling pathway	11.02.03.04.03;30.05.02.24	transcription repression;G-protein coupled receptor signalling pathway	16221676	The class II HDAC5 binds to GNB1/GNG2 via itsC-terminal domain. The transcriptional co-repressionactivity is then inhibited.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;Histone deacetylase 5	GNG2;GNB1;HDAC5	None;None;KIAA0600
1620	G protein complex (HDAC4, GNB1, GNG2)	Human	None	HEK293A cells	P56524;P59768;P62873	9759;54331;2782	MI:0018-two hybrid;MI:0019-coimmunoprecipitation	GO:0045892;GO:0007186	negative regulation of DNA-templated transcription;G protein-coupled receptor signaling pathway	11.02.03.04.03;30.05.02.24	transcription repression;G-protein coupled receptor signalling pathway	16221676	The class II HDAC4 binds to GNB1/GNG2 via itsC-terminal domain. The transcriptional co-repressionactivity is then inhibited.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone deacetylase 4;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	HDAC4;GNG2;GNB1	KIAA0288;None;None
1623	FA core complex 1	Human	Fanconi anemia core complex 1	None	O15287;O15360;Q00597;Q9HB96;Q9NPI8	2189;2175;2176;2178;2188	MI:0027-cosedimentation	GO:0016567;GO:0006974;GO:0005634	protein ubiquitination;cellular response to DNA damage stimulus;nucleus	14.07.05;32.01.09;70.10	modification by ubiquitination, deubiquitination;DNA damage response;nucleus	12093742	FANCE functions to target cytoplasmic FANCC to the nucleus.	FA complex is involved in Fanconi anemia (FA) disease.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Fanconi anemia group G protein;Fanconi anemia group A protein;Fanconi anemia group C protein;Fanconi anemia group E protein;Fanconi anemia group F protein	FANCG;FANCA;FANCC;FANCE;FANCF	XRCC9;FAA FACA FANCH;FAC FACC;FACE;None
1624	FA core complex (Fanconi anemia core complex)	Human	None	None	O15287;O15360;Q00597;Q0VG06;Q8IYD8;Q8NB91;Q9HB96;Q9NPI8;Q9NW38	2189;2175;2176;80233;57697;2187;2178;2188;55120	MI:0007-anti tag coimmunoprecipitation	GO:0016567;GO:0006974;GO:0005634	protein ubiquitination;cellular response to DNA damage stimulus;nucleus	14.07.05;32.01.09;70.10	modification by ubiquitination, deubiquitination;DNA damage response;nucleus	15502827	None	FA complex is involved in Fanconi anemia (FA) disease.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Fanconi anemia group G protein;Fanconi anemia group A protein;Fanconi anemia group C protein;Fanconi anemia core complex-associated protein 100;Fanconi anemia group M protein;Fanconi anemia group B protein;Fanconi anemia group E protein;Fanconi anemia group F protein;E3 ubiquitin-protein ligase FANCL	FANCG;FANCA;FANCC;FAAP100;FANCM;FANCB;FANCE;FANCF;FANCL	XRCC9;FAA FACA FANCH;FAC FACC;C17orf70;KIAA1596;None;FACE;None;PHF9
1625	FA core complex (Fanconi anemia core complex)	Human	None	None	O15287;O15360;Q00597;Q8IYD8;Q8NB91;Q9HB96;Q9NPI8	2189;2175;2176;57697;2187;2178;2188	MI:0006-anti bait coimmunoprecipitation	GO:0016567;GO:0006974;GO:0005634	protein ubiquitination;cellular response to DNA damage stimulus;nucleus	14.07.05;32.01.09;70.10	modification by ubiquitination, deubiquitination;DNA damage response;nucleus	16116434	None	FA complex is involved in Fanconi anemia (FA) disease.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Fanconi anemia group G protein;Fanconi anemia group A protein;Fanconi anemia group C protein;Fanconi anemia group M protein;Fanconi anemia group B protein;Fanconi anemia group E protein;Fanconi anemia group F protein	FANCG;FANCA;FANCC;FANCM;FANCB;FANCE;FANCF	XRCC9;FAA FACA FANCH;FAC FACC;KIAA1596;None;FACE;None
1633	CyclinD1-CDK4-CDK6 complex	Human	None	None	P11802;P24385;Q00534	1019;595;1021	MI:0007-anti tag coimmunoprecipitation	GO:0000278;GO:0000082;GO:0035556;GO:0007519	mitotic cell cycle;G1/S transition of mitotic cell cycle;intracellular signal transduction;skeletal muscle tissue development	10.03.01.01;10.03.01.01.03;30.01;41.05.15	mitotic cell cycle;G1/S transition of mitotic cell cycle;cellular signalling;myogenesis	8930396	Upon myocyte differentiation subunit composition of the CDK4/6 complex is altered. Interaction with cyclinD1 is reduced but interaction with cyclinD3 and p21 is enhanced thus inhibiting the kinase activity of CDK4/6.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cyclin-dependent kinase 4;G1/S-specific cyclin-D1;Cyclin-dependent kinase 6	CDK4;CCND1;CDK6	None;BCL1 PRAD1;CDKN6
1634	CyclinD1-CDK4-p21 complex	Human	None	BHK21 cells	P11802;P24385;P38936	1019;595;1026	MI:0006-anti bait coimmunoprecipitation	GO:0035556;GO:0051726	intracellular signal transduction;regulation of cell cycle	30.01;10.03.01	cellular signalling;mitotic cell cycle and cell cycle control	9467962	None	None	Since CCND1, CDKN1A and CDK4 from hamster were not available in the Uniprot database at the time of annotation, the orthologous human proteins were used.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cyclin-dependent kinase 4;G1/S-specific cyclin-D1;Cyclin-dependent kinase inhibitor 1	CDK4;CCND1;CDKN1A	None;BCL1 PRAD1;CAP20 CDKN1 CIP1 MDA6 PIC1 SDI1 WAF1
1642	p16-cyclin D2-CDK4 complex	Human	None	None	P11802;P30279;P42771	1019;894;1029	MI:0006-anti bait coimmunoprecipitation	GO:0000278;GO:0051726;GO:0035556	mitotic cell cycle;regulation of cell cycle;intracellular signal transduction	10.03.01.01;10.03.01;30.01	mitotic cell cycle;mitotic cell cycle and cell cycle control;cellular signalling	7739547	p16 binds to preassembled cyclinD-CDK complex in vitro and inhibits their activity without replacing Cyclin D. However, affinity for p16 to the uncomplexed CDK4 is higher.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cyclin-dependent kinase 4;G1/S-specific cyclin-D2;Cyclin-dependent kinase inhibitor 2A	CDK4;CCND2;CDKN2A	None;None;CDKN2 MTS1
1656	p27-cyclinE-CDK2 complex	Human	None	None	P24864;P24941;P46527	898;1017;1027	MI:0007-anti tag coimmunoprecipitation	GO:0000082;GO:0005634	G1/S transition of mitotic cell cycle;nucleus	10.03.01.01.03;70.10	G1/S transition of mitotic cell cycle;nucleus	17409098	p27, an important cell cycle regulator, blocks the G1/S transition in cells by binding and inhibiting Cdk2/cyclin A and Cdk2/cyclin E complexes. Ubiquitination and subsequent degradation play a critical role in regulating the levels of p27 during cell cycle progression.	Overexpression of p27 in certain cancer cells prevents DNA replication and tumor formation in nude mice, whereas the loss of p27 has been reported in many human cancers and predicts a poor prognosis in breast, prostate, colon, gastric, lung, and esophageal cancers.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	G1/S-specific cyclin-E1;Cyclin-dependent kinase 2;Cyclin-dependent kinase inhibitor 1B	CCNE1;CDK2;CDKN1B	CCNE;CDKN2;KIP1 p27
1661	E2F4-p107-cyclinA complex	Human	None	MCF-7 cells	P20248;P28749;Q16254	890;5933;1874	MI:0412-electrophoretic mobility supershift assay	GO:0000082;GO:0005634	G1/S transition of mitotic cell cycle;nucleus	10.03.01.01.03;70.10	G1/S transition of mitotic cell cycle;nucleus	12096339	In proliferating MCF-7 cells the complex contains mostly cyclin A. After overexpression of cyclin E most of the complexes contain cyclin E.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cyclin-A2;Retinoblastoma-like protein 1;Transcription factor E2F4	CCNA2;RBL1;E2F4	CCN1 CCNA;None;None
1695	SCAMP1-SCAMP2 complex	Human	None	None	O15126;O15127	9522;10066	MI:0019-coimmunoprecipitation;MI:0030-cross-linking study;MI:0113-western blot	GO:0015031;GO:0006892;GO:0016192;GO:0140318	protein transport;post-Golgi vesicle-mediated transport;vesicle-mediated transport;protein transporter activity	20.01.10;20.09.07.06;20.09.07	protein transport;post Golgi transport;vesicular transport (Golgi network, etc.)	9224770	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Secretory carrier-associated membrane protein 1;Secretory carrier-associated membrane protein 2	SCAMP1;SCAMP2	SCAMP;None
1700	ABL2-HRAS-RIN1 complex	Human	None	None	P01112;P42684;Q13671	3265;27;9610	MI:0019-coimmunoprecipitation	GO:0035556	intracellular signal transduction	30.01	cellular signalling	15886098	The formation of this stable complex is consistent with a pathway connecting RAS proteins with the cytoplasmic functions of ABL-family tyrosine kinases through RIN1.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	GTPase HRas;Tyrosine-protein kinase ABL2;Ras and Rab interactor 1	HRAS;ABL2;RIN1	HRAS1;ABLL ARG;None
1703	IGHM-VPREB1-IGLL1 complex	Human	None	None	P01871;P12018;P15814	3507;7441;3543	MI:0019-coimmunoprecipitation	GO:0030183	B cell differentiation	43.03.07.02.01.01	B-cell	11564802	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Immunoglobulin heavy constant mu;Immunoglobulin iota chain;Immunoglobulin lambda-like polypeptide 1	IGHM;VPREB1;IGLL1	None;VPREB;IGL1
1707	IL2-IL2RA-IL2RB complex	Human	None	None	P01589;P14784;P60568	3559;3560;3558	MI:0019-coimmunoprecipitation	GO:0023052	signaling	30.01	cellular signalling	2303462	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Interleukin-2 receptor subunit alpha;Interleukin-2 receptor subunit beta;Interleukin-2	IL2RA;IL2RB;IL2	None;IL15RB;None
1714	TICAM1-TICAM2-TLR4 complex	Human	TLR4-TICAM1-TICAM2 complex; Toll-like receptor 4-TICAM1-TICAM2 complex; TICAM1-TICAM2-TLR4 complex; TLR4-TRAM-TRIF complex	HEK293 cells	O00206;Q86XR7;Q8IUC6	7099;None;148022	MI:0019-coimmunoprecipitation	GO:0001530;GO:0032496;GO:0045087;GO:0002221;GO:0002756;GO:0034142;GO:0042742;GO:0002224;GO:0035667;GO:0035669;GO:0032728;GO:0032481	lipopolysaccharide binding;response to lipopolysaccharide;innate immune response;pattern recognition receptor signaling pathway;MyD88-independent toll-like receptor signaling pathway;toll-like receptor 4 signaling pathway;defense response to bacterium;toll-like receptor signaling pathway;TRIF-dependent toll-like receptor 4 signaling pathway;TRAM-dependent toll-like receptor 4 signaling pathway;positive regulation of interferon-beta production;positive regulation of type I interferon production	36.25.16.01	innate immune response (invertebrates and vertebrates)	14519765	TICAM-2 (TRAM) physically bridges TLR4 and TICAM-1 (TRIF) and functionally transmits LPS-TLR4 signaling to TICAM-1, which in turn activates IRF-3.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Toll-like receptor 4;TIR domain-containing adapter molecule 2;TIR domain-containing adapter molecule 1	TLR4;TICAM2;TICAM1	None;TIRAP3 TIRP TRAM;PRVTIRB TRIF
1728	CTCF-nucleophosmin-PARP-HIS-KPNA-LMNA-TOP complex	Human	None	None	O00505;P02545;P06748;P09874;P0C0S5;P11388;P49711;P52294;Q6FI13	None;4000;4869;142;3015;7153;10664;3836;None	MI:0004-affinity chromatography technology;MI:0006-anti bait coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:2001141;GO:0006355;GO:0005634	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;nucleus	11.02.03.04;70.10	transcriptional control;nucleus	14759373	Nucleophosmin is the most prominent binding partner of CTCF.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Importin subunit alpha-4;Prelamin-A/C;Nucleophosmin;Poly [ADP-ribose] polymerase 1;Histone H2A.Z;DNA topoisomerase 2-alpha;Transcriptional repressor CTCF;Importin subunit alpha-5;Histone H2A type 2-A	KPNA3;LMNA;NPM1;PARP1;H2AZ1;TOP2A;CTCF;KPNA1;H2AC18	QIP2;LMN1;NPM;ADPRT PPOL;H2AFZ H2AZ;TOP2;None;RCH2;H2AFO HIST2H2AA HIST2H2AA3
1729	TLE1 corepressor complex (MASH1 promoter-corepressor complex)	Human	None	brain	P06748;P09874;P19338;P34932;P35580;P60709;Q02880;Q04724;Q15233;Q92878	4869;142;4691;3308;4628;60;7155;7088;4841;10111	MI:0007-anti tag coimmunoprecipitation;MI:0402-chromatin immunoprecipitation assay;MI:0676-tandem affinity purification	GO:0045892;GO:0005515;GO:0003677;GO:0051090;GO:0030182;GO:0005634	negative regulation of DNA-templated transcription;protein binding;DNA binding;regulation of DNA-binding transcription factor activity;neuron differentiation;nucleus	11.02.03.04.03;16.01;16.03.01;18.02.09;43.03.13;70.10	transcription repression;protein binding;DNA binding;regulator of transcription factor;neuron;nucleus	15607978	The TLE1 complex is required for HES1-mediated transcription repression. PARP1 is inactive in the TLE1 complex. After Ca(2+) induction, kinase CaMKII-delta activates PARP1 leading to dismissal of the TLE1 corepresspor complex from HES1.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Nucleophosmin;Poly [ADP-ribose] polymerase 1;Nucleolin;Heat shock 70 kDa protein 4;Myosin-10;Actin, cytoplasmic 1;DNA topoisomerase 2-beta;Transducin-like enhancer protein 1;Non-POU domain-containing octamer-binding protein;DNA repair protein RAD50	NPM1;PARP1;NCL;HSPA4;MYH10;ACTB;TOP2B;TLE1;NONO;RAD50	NPM;ADPRT PPOL;None;APG2;None;None;None;None;NRB54;None
1731	PRMT1 complex	Human	None	None	Q99873	3276	MI:0007-anti tag coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0018126;GO:0006479;GO:0005634	protein hydroxylation;protein methylation;nucleus	14.07.09;70.10	posttranslational modification of amino acids (e.g. hydroxylation, methylation);nucleus	11152681	PRMT1 (protein-arginine methyltransferase) formes distinct homo-oligomeric complexes, including a dimer and tetramer.	None	None	Homo sapiens (Human)	Protein arginine N-methyltransferase 1	PRMT1	HMT2 HRMT1L2 IR1B4
1734	SF3A1-SF3A2-SF3A3 complex	Human	None	None	Q12874;Q15428;Q15459	10946;8175;10291	MI:0019-coimmunoprecipitation	GO:0008380;GO:0005634	RNA splicing;nucleus	11.04.03.01;70.10	splicing;nucleus	11533230	All SF3A subunits are essential for the formation of the mature 17S U2 snRNP and the prespliceosome.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Splicing factor 3A subunit 3;Splicing factor 3A subunit 2;Splicing factor 3A subunit 1	SF3A3;SF3A2;SF3A1	SAP61;SAP62;SAP114
1737	SF3b complex	Human	None	None	O75533;Q13435;Q15393;Q15427;Q7RTV0;Q86XP3;Q9BWJ5;Q9Y3B4	23451;10992;23450;10262;84844;11325;83443;51639	MI:0019-coimmunoprecipitation	GO:0008380;GO:0005634	RNA splicing;nucleus	11.04.03.01;70.10	splicing;nucleus	12234937	The splicing factor SF3b is a multiprotein complex essential for the accurate excision of introns from pre-messenger RNA (PMID:12738865).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Splicing factor 3B subunit 1;Splicing factor 3B subunit 2;Splicing factor 3B subunit 3;Splicing factor 3B subunit 4;PHD finger-like domain-containing protein 5A;ATP-dependent RNA helicase DDX42;Splicing factor 3B subunit 5;Splicing factor 3B subunit 6	SF3B1;SF3B2;SF3B3;SF3B4;PHF5A;DDX42;SF3B5;SF3B6	SAP155;SAP145;KIAA0017 SAP130;SAP49;None;None;SF3B10;SAP14 SF3B14 SF3B14A
1743	(E.F.G) complex	Human	None	None	P62304;P62306;P62308	6635;6636;6637	MI:0028-cosedimentation in solution;MI:0114-x-ray crystallography	GO:0005634;GO:0000387	nucleus;spliceosomal snRNP assembly	70.10	nucleus	9020971	All four spliceosomal small nuclear ribonucleoproteins (snRNPs) U1, U2, U4/U6 and U5 contain a common structural element called the snRNP core. This core is assembled from the common snRNP proteins and the small nuclear RNA (snRNA). The RNA-free (E.F.G) complex contains the smallest U1 and U5 snRNP core proteins, i.e. E, F and G.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Small nuclear ribonucleoprotein E;Small nuclear ribonucleoprotein F;Small nuclear ribonucleoprotein G	SNRPE;SNRPF;SNRPG	None;PBSCF;PBSCG
1745	SMN complex	Human	None	HeLa cells	O14893;P09012;P14678;P57678;P62304;P62306;P62308;P62314;P62316;P62318;P63162;Q8TEQ6;Q8WXD5;Q9H840;Q9UHI6	8487;6626;6628;50628;6635;6636;6637;6632;6633;6634;6638;25929;79833;79760;11218	MI:0007-anti tag coimmunoprecipitation	GO:0008380;GO:0032774;GO:0003723;GO:0005737;GO:0005634;GO:0065003	RNA splicing;RNA biosynthetic process;RNA binding;cytoplasm;nucleus;protein-containing complex assembly	11.04.03.01;11.02;16.03.03;70.03;70.10	splicing;RNA synthesis;RNA binding;cytoplasm;nucleus	11748230	Assembly of the Sm-class of U-rich small nuclear ribonucleoprotein particles (U snRNPs) is a process facilitated by the macromolecular survival of motor neuron (SMN) complex. The SMN complex is found both in the cytoplasm and in the nucleus, where it is concentrated in gems, nuclear bodies similar in size and number to Cajal (coiled) bodies and often associated with them.	Spinal muscular atrophy (SMA) is the most common genetic cause of infant mortality. Deletions or mutations in the survival of motor neurons (SMN1) gene, the SMA-causing gene, are detected in over 95% of SMA patients.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Gem-associated protein 2;U1 small nuclear ribonucleoprotein A;Small nuclear ribonucleoprotein-associated proteins B and B';Gem-associated protein 4;Small nuclear ribonucleoprotein E;Small nuclear ribonucleoprotein F;Small nuclear ribonucleoprotein G;Small nuclear ribonucleoprotein Sm D1;Small nuclear ribonucleoprotein Sm D2;Small nuclear ribonucleoprotein Sm D3;Small nuclear ribonucleoprotein-associated protein N;Gem-associated protein 5;Gem-associated protein 6;Gem-associated protein 7;Probable ATP-dependent RNA helicase DDX20	GEMIN2;SNRPA;SNRPB;GEMIN4;SNRPE;SNRPF;SNRPG;SNRPD1;SNRPD2;SNRPD3;SNRPN;GEMIN5;GEMIN6;GEMIN7;DDX20	SIP1;None;COD SNRPB1;None;None;PBSCF;PBSCG;None;SNRPD1;None;HCERN3 SMN;None;None;None;DP103 GEMIN3
1746	SMN containing complex	Human	None	HeLa S3 cells	O14893;P09382;P17931;P57678;P62314;P62316;P62318;Q16637	8487;3956;3958;50628;6632;6633;6634;None	MI:0019-coimmunoprecipitation	GO:0008380;GO:0032774;GO:0003723;GO:0005634;GO:0065003	RNA splicing;RNA biosynthetic process;RNA binding;nucleus;protein-containing complex assembly	11.04.03.01;11.02;16.03.03;70.10	splicing;RNA synthesis;RNA binding;nucleus	11522829	Evidence suggests a role for SMN containing complex in spliceosome assembly.	Spinal muscular atrophy (SMA), (PMID:10601333)	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Gem-associated protein 2;Galectin-1;Galectin-3;Gem-associated protein 4;Small nuclear ribonucleoprotein Sm D1;Small nuclear ribonucleoprotein Sm D2;Small nuclear ribonucleoprotein Sm D3;Survival motor neuron protein	GEMIN2;LGALS1;LGALS3;GEMIN4;SNRPD1;SNRPD2;SNRPD3;SMN1	SIP1;None;MAC2;None;None;SNRPD1;None;SMN SMNT
1749	SMN-PolII-RHA complex	Human	None	HeLa cells	O14893;P08579;P14678;P20226;P24928;P57678;P63162;Q00403;Q08211;Q9UHI6	8487;6629;6628;6908;5430;50628;6638;2959;1660;11218	MI:0019-coimmunoprecipitation	GO:0008380;GO:0032774;GO:0003723;GO:0005737;GO:0005634;GO:0065003	RNA splicing;RNA biosynthetic process;RNA binding;cytoplasm;nucleus;protein-containing complex assembly	11.04.03.01;11.02;16.03.03;70.03;70.10	splicing;RNA synthesis;RNA binding;cytoplasm;nucleus	11149922	Physical association between the Survival Motor Neuron (SMN) complex, RNA polymerase II (pol II), snRNPs and RNA helicase A (RHA) suggest a role for the SMN complex in the assembly of the pol II transcription/processing machinery. SMN localizes both in the cytoplasm and in gems, nuclear bodies similar in size and number to coiled bodies (Cajal bodies) and often associated with them.	Spinal muscular atrophy (SMA)	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Gem-associated protein 2;U2 small nuclear ribonucleoprotein B'';Small nuclear ribonucleoprotein-associated proteins B and B';TATA-box-binding protein;DNA-directed RNA polymerase II subunit RPB1;Gem-associated protein 4;Small nuclear ribonucleoprotein-associated protein N;Transcription initiation factor IIB;ATP-dependent RNA helicase A;Probable ATP-dependent RNA helicase DDX20	GEMIN2;SNRPB2;SNRPB;TBP;POLR2A;GEMIN4;SNRPN;GTF2B;DHX9;DDX20	SIP1;None;COD SNRPB1;GTF2D1 TF2D TFIID;POLR2;None;HCERN3 SMN;TF2B TFIIB;DDX9 LKP NDH2;DP103 GEMIN3
1750	PPP4C-PPP4R2-Gemin3-Gemin4 complex	Human	None	None	P57678;P60510;Q9NY27;Q9UHI6	50628;5531;151987;11218	MI:0007-anti tag coimmunoprecipitation	GO:0006470;GO:0005634	protein dephosphorylation;nucleus	14.07.03;70.10	modification by phosphorylation, dephosphorylation, autophosphorylation;nucleus	12668731	PPP4c is a member of the PPP family of protein phosphatases. PPP4 exists as high molecular mass complex of 450-600 kDa, and two putative regulatory subunits have been identified, R1 and R2. Protein phosphatase 4 interacts also with the Survival of Motor Neurons (SMN) complex and enhances the temporal localisation of snRNPs.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Gem-associated protein 4;Serine/threonine-protein phosphatase 4 catalytic subunit;Serine/threonine-protein phosphatase 4 regulatory subunit 2;Probable ATP-dependent RNA helicase DDX20	GEMIN4;PPP4C;PPP4R2;DDX20	None;PPP4 PPX;None;DP103 GEMIN3
1751	SMN complex	Human	None	HeLa cells	O14893;P09012;P14678;P57678;Q16637;Q8TEQ6;Q8WXD5;Q9H840;Q9UHI6;Q9Y3F4	8487;6626;6628;50628;None;25929;79833;79760;11218;11171	MI:0004-affinity chromatography technology	GO:0008380;GO:0032774;GO:0003723;GO:0006811;GO:0050658;GO:0051033;GO:0051169;GO:0005737;GO:0005634;GO:0065003	RNA splicing;RNA biosynthetic process;RNA binding;ion transport;RNA transport;RNA transmembrane transporter activity;nuclear transport;cytoplasm;nucleus;protein-containing complex assembly	11.04.03.01;11.02;16.03.03;20.01.01;20.01.21;20.09.01;70.03;70.10	splicing;RNA synthesis;RNA binding;ion transport;RNA transport;nuclear transport;cytoplasm;nucleus	15494309	Survival of motor neurons (SMN) protein import depends on the presence of Sm snRNPs. Conversely, import of labeled U1 snRNPs was SMN complex dependent. Thus, import of SMN and U snRNPs are coupled in spinal muscular atrophy (SMA).	Spinal muscular atrophy (SMA)	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Gem-associated protein 2;U1 small nuclear ribonucleoprotein A;Small nuclear ribonucleoprotein-associated proteins B and B';Gem-associated protein 4;Survival motor neuron protein;Gem-associated protein 5;Gem-associated protein 6;Gem-associated protein 7;Probable ATP-dependent RNA helicase DDX20;Serine-threonine kinase receptor-associated protein	GEMIN2;SNRPA;SNRPB;GEMIN4;SMN1;GEMIN5;GEMIN6;GEMIN7;DDX20;STRAP	SIP1;None;COD SNRPB1;None;SMN SMNT;None;None;None;DP103 GEMIN3;MAWD UNRIP
1752	SMN complex	Human	None	HeLa Tet-ON cells	O14893;P57678;Q16637;Q8TEQ6;Q8WXD5;Q9H840;Q9UHI6	8487;50628;None;25929;79833;79760;11218	MI:0007-anti tag coimmunoprecipitation	GO:0008380;GO:0032774;GO:0003723;GO:0005737;GO:0005634;GO:0065003	RNA splicing;RNA biosynthetic process;RNA binding;cytoplasm;nucleus;protein-containing complex assembly	11.04.03.01;11.02;16.03.03;70.03;70.10	splicing;RNA synthesis;RNA binding;cytoplasm;nucleus	12065586	The survival of motor neurons (SMN) protein is the product of the gene mutated or deleted in the neurodegenerative disease, spinal muscular atrophy. SMN is part of a large macromolecular complex that also contains Gemin2, Gemin3, Gemin4, Gemin5, and Gemin6. The SMN complex functions in the assembly of spliceosomal small nuclear ribonucleoproteins and probably other ribonucleoprotein particles. The SMN complex is found both in the cytoplasm and in the nucleus where it is concentrated in gems, nuclear bodies similar in size and number to Cajal bodies (coiled bodies (CBs) and often associated with them.	Spinal muscular atrophy (SMA)	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Gem-associated protein 2;Gem-associated protein 4;Survival motor neuron protein;Gem-associated protein 5;Gem-associated protein 6;Gem-associated protein 7;Probable ATP-dependent RNA helicase DDX20	GEMIN2;GEMIN4;SMN1;GEMIN5;GEMIN6;GEMIN7;DDX20	SIP1;None;SMN SMNT;None;None;None;DP103 GEMIN3
1760	TOP1-PSF-P54 complex	Human	None	None	P11387;P23246;Q15233	7150;6421;4841	MI:0004-affinity chromatography technology	GO:0008380;GO:0005634	RNA splicing;nucleus	11.04.03.01;70.10	splicing;nucleus	9756848	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA topoisomerase 1;Splicing factor, proline- and glutamine-rich;Non-POU domain-containing octamer-binding protein	TOP1;SFPQ;NONO	None;PSF;NRB54
1767	CPSF6-ITCH-NUDT21-POLR2A-UBAP2L complex	Human	None	293T cells	O43809;P24928;Q14157;Q16630;Q96J02	11051;5430;9898;11052;83737	MI:0096-pull down	GO:0006351;GO:0006396;GO:0001817	DNA-templated transcription;RNA processing;regulation of cytokine production	11;11.04	TRANSCRIPTION;RNA processing	16055720	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cleavage and polyadenylation specificity factor subunit 5;DNA-directed RNA polymerase II subunit RPB1;Ubiquitin-associated protein 2-like;Cleavage and polyadenylation specificity factor subunit 6;E3 ubiquitin-protein ligase Itchy homolog	NUDT21;POLR2A;UBAP2L;CPSF6;ITCH	CFIM25 CPSF25 CPSF5;POLR2;KIAA0144 NICE4;CFIM68;None
1768	CPSF6-EWSR1-ITCH-NUDT21-POLR2A-UBAP2L complex	Human	None	293T cells	O43809;P24928;Q01844;Q14157;Q16630;Q96J02	11051;5430;2130;9898;11052;83737	MI:0096-pull down	GO:0001817;GO:0006396;GO:0006351	regulation of cytokine production;RNA processing;DNA-templated transcription	11.04;11	RNA processing;TRANSCRIPTION	16055720	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cleavage and polyadenylation specificity factor subunit 5;DNA-directed RNA polymerase II subunit RPB1;RNA-binding protein EWS;Ubiquitin-associated protein 2-like;Cleavage and polyadenylation specificity factor subunit 6;E3 ubiquitin-protein ligase Itchy homolog	NUDT21;POLR2A;EWSR1;UBAP2L;CPSF6;ITCH	CFIM25 CPSF25 CPSF5;POLR2;EWS;KIAA0144 NICE4;CFIM68;None
1769	CPSF6-ITCH-NUDT21-POLR2A complex	Human	None	293T cells	O43809;P24928;Q16630;Q96J02	11051;5430;11052;83737	MI:0096-pull down	GO:0001817;GO:0006396;GO:0006351	regulation of cytokine production;RNA processing;DNA-templated transcription	11.04;11	RNA processing;TRANSCRIPTION	16055720	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cleavage and polyadenylation specificity factor subunit 5;DNA-directed RNA polymerase II subunit RPB1;Cleavage and polyadenylation specificity factor subunit 6;E3 ubiquitin-protein ligase Itchy homolog	NUDT21;POLR2A;CPSF6;ITCH	CFIM25 CPSF25 CPSF5;POLR2;CFIM68;None
1772	MICB-KLRK1-HCST complex	Human	None	None	P26718;Q29980;Q9UBK5	22914;4277;10870	MI:0004-affinity chromatography technology	GO:0006955	immune response	36.25.16	immune response	11239445	The ULBPs and the MICs share the property of binding to the NKG2D/DAP10 receptor and provide a positive signal for NK cell activation and cytotoxicity that can override the negative signal mediated by MHC class I/KIR engagement.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	NKG2-D type II integral membrane protein;MHC class I polypeptide-related sequence B;Hematopoietic cell signal transducer	KLRK1;MICB;HCST	D12S2489E NKG2D;PERB11.2;DAP10 KAP10 PIK3AP
1773	ULBP3-KLRK1-HCST complex	Human	None	None	P26718;Q9BZM4;Q9UBK5	22914;79465;10870	MI:0004-affinity chromatography technology	GO:0006955	immune response	36.25.16	immune response	11239445	The ULBPs and the MICs share the property of binding to the NKG2D/DAP10 receptor and provide a positive signal for NK cell activation and cytotoxicity that can override the negative signal mediated by MHC class I/KIR engagement.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	NKG2-D type II integral membrane protein;UL16-binding protein 3;Hematopoietic cell signal transducer	KLRK1;ULBP3;HCST	D12S2489E NKG2D;N2DL3 RAET1N;DAP10 KAP10 PIK3AP
1774	MICA-KLRK1-HCST complex	Human	None	None	P26718;Q29983;Q9UBK5	22914;100507436;10870	MI:0004-affinity chromatography technology	GO:0006955	immune response	36.25.16	immune response	11239445	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	NKG2-D type II integral membrane protein;MHC class I polypeptide-related sequence A;Hematopoietic cell signal transducer	KLRK1;MICA;HCST	D12S2489E NKG2D;PERB11.1;DAP10 KAP10 PIK3AP
1775	ULBP2-KLRK1-HCST complex	Human	None	None	P26718;Q9BZM5;Q9UBK5	22914;80328;10870	MI:0004-affinity chromatography technology	GO:0006955	immune response	36.25.16	immune response	11239445	The ULBPs and the MICs share the property of binding to the NKG2D/DAP10 receptor and provide a positive signal for NK cell activation and cytotoxicity that can override the negative signal mediated by MHC class I/KIR engagement.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	NKG2-D type II integral membrane protein;UL16-binding protein 2;Hematopoietic cell signal transducer	KLRK1;ULBP2;HCST	D12S2489E NKG2D;N2DL2 RAET1H;DAP10 KAP10 PIK3AP
1777	Ubiquitin E3 ligase (SMURF2, SMAD7) - TGF(beta)	Human	TGF-beta-receptor-SMAD7-SMURF2 complex	COS cells	O15105;P36897;P37173;Q9HAU4	4092;7046;7048;64750	MI:0007-anti tag coimmunoprecipitation	GO:0007179;GO:0005737;GO:0016567;GO:0006511	transforming growth factor beta receptor signaling pathway;cytoplasm;protein ubiquitination;ubiquitin-dependent protein catabolic process	30.05.01.18.01;70.03;14.07.05;14.13.01.01	TGF-beta-receptor signalling pathway;cytoplasm;modification by ubiquitination, deubiquitination;proteasomal degradation (ubiquitin/proteasomal pathway)	11163210	SMAD7 mediates the interaction of SMURF2 with TGF-beta-receptor complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mothers against decapentaplegic homolog 7;TGF-beta receptor type-1;TGF-beta receptor type-2;E3 ubiquitin-protein ligase SMURF2	SMAD7;TGFBR1;TGFBR2;SMURF2	MADH7 MADH8;ALK5 SKR4;None;None
1779	TGF-beta-receptor-PAR6 complex	Human	None	None	P36897;P37173;Q9NPB6	7046;7048;50855	MI:0007-anti tag coimmunoprecipitation;MI:0729-luminescence based mammalian interactome mapping	GO:0007179;GO:0007043;GO:0030054	transforming growth factor beta receptor signaling pathway;cell-cell junction assembly;cell junction	30.05.01.18.01;42.06.04;70.06	TGF-beta-receptor signalling pathway;intercellular junction (gap junction/adherens junction);cell junction	15761148	PAR6 interacts directly with TGFBR1.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	TGF-beta receptor type-1;TGF-beta receptor type-2;Partitioning defective 6 homolog alpha	TGFBR1;TGFBR2;PARD6A	ALK5 SKR4;None;PAR6A
1783	Ubiquitin E3 ligase (SMAD7, SMURF1) - TGFBR1	Human	TGF-beta receptor I-SMAD7-SMURF1 complex	COS cells	O15105;P36897;Q9HCE7	4092;7046;57154	MI:0007-anti tag coimmunoprecipitation	GO:0016567;GO:0043161;GO:0006511;GO:0007179;GO:0005737	protein ubiquitination;proteasome-mediated ubiquitin-dependent protein catabolic process;ubiquitin-dependent protein catabolic process;transforming growth factor beta receptor signaling pathway;cytoplasm	14.07.05;14.13.01.01;30.05.01.18.01;70.03	modification by ubiquitination, deubiquitination;proteasomal degradation (ubiquitin/proteasomal pathway);TGF-beta-receptor signalling pathway;cytoplasm	11278251	SMAD7 associates with SMURF1 in the nucleus and is exported to the cytoplasm. Thus SMAD7 recruits SMURF1 to TGF-betaRI, resulting in the degradation of Tgf-betaRI.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mothers against decapentaplegic homolog 7;TGF-beta receptor type-1;E3 ubiquitin-protein ligase SMURF1	SMAD7;TGFBR1;SMURF1	MADH7 MADH8;ALK5 SKR4;KIAA1625
1784	RNF11-SMURF2-STAMBP complex	Human	None	None	O95630;Q9HAU4;Q9Y3C5	10617;64750;26994	MI:0019-coimmunoprecipitation	GO:0043161;GO:0006511	proteasome-mediated ubiquitin-dependent protein catabolic process;ubiquitin-dependent protein catabolic process	14.13.01.01	proteasomal degradation (ubiquitin/proteasomal pathway)	14755250	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	STAM-binding protein;E3 ubiquitin-protein ligase SMURF2;RING finger protein 11	STAMBP;SMURF2;RNF11	AMSH;None;
1787	Nogo-potassium channel complex	Human	None	central nervous system	P16389;P78357;Q09470;Q9NQC3	3737;8506;3736;57142	MI:0019-coimmunoprecipitation	GO:0008324;GO:0006812;GO:0005216;GO:0022008;GO:0048699;GO:0007417	cation transmembrane transporter activity;cation transport;ion channel activity;neurogenesis;generation of neurons;central nervous system development	20.01.01.01;20.03.01.01;41.05.13;47.03.01.01	cation transport (H+, Na+, K+, Ca2+ , NH4+, etc.);ion channels;neurogenesis;central nervous system	14592966	Nogo-A is mainly localized at thegaps between Na+ and K+ channels along axons and its immunoreactivity is clearly located at sites where glialloops make contact with the axonal membrane surface inadult CNS. Nogo-A is a paranodal glial component.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Potassium voltage-gated channel subfamily A member 2;Contactin-associated protein 1;Potassium voltage-gated channel subfamily A member 1;Reticulon-4	KCNA2;CNTNAP1;KCNA1;RTN4	None;CASPR NRXN4;None;KIAA0886 NOGO
1793	LINGO1-RTN4R-NGFR complex	Human	LINGO-1-Nogo-66-p75 signaling complex	COS-7 cells, CG (ciliary ganglion) neurons	P08138;Q96FE5;Q9BZR6	4804;84894;65078	MI:0019-coimmunoprecipitation;MI:0411-enzyme linked immunosorbent assay	GO:0022008;GO:0048699;GO:0031175	neurogenesis;generation of neurons;neuron projection development	41.05.13	neurogenesis	14966521	Triply transfected cells responded to OMgp by activating RhoA, but no activation occurred when binary pairs of NgR1/p75, LINGO-1/p75 or NgR1/LINGO-1 were tested.The binding of LINGO-1 to NgR1, p75 or to both together during CNS development or in response to injury, may modulate RhoA activation status in neurons, and thus control axon growth and extension.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Tumor necrosis factor receptor superfamily member 16;Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1;Reticulon-4 receptor	NGFR;LINGO1;RTN4R	TNFRSF16;LERN1 LRRN6A;NOGOR
1794	SORT1-NGFR complex	Human	None	None	P08138;Q99523	4804;6272	MI:0019-coimmunoprecipitation;MI:0030-cross-linking study	GO:0005515;GO:0005737	protein binding;cytoplasm	16.01;70.03	protein binding;cytoplasm	14985763	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Tumor necrosis factor receptor superfamily member 16;Sortilin	NGFR;SORT1	TNFRSF16;None
1795	SORT1-NGFR-NGFB complex	Human	None	None	P01138;P08138;Q99523	4803;4804;6272	MI:0030-cross-linking study	GO:0006915	apoptotic process	40.10.02	apoptosis (type I programmed cell death)	14985763	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Beta-nerve growth factor;Tumor necrosis factor receptor superfamily member 16;Sortilin	NGF;NGFR;SORT1	NGFB;TNFRSF16;None
1810	ITGA4-PXN-GIT1 complex	Human	None	Jurkat cells	P13612;P49023;Q9Y2X7	3676;5829;28964	MI:0004-affinity chromatography technology	GO:0016477	cell migration	34.05.01	cell migration	15793570	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin alpha-4;Paxillin;ARF GTPase-activating protein GIT1	ITGA4;PXN;GIT1	CD49D;None;None
1812	AXIN-MEKK4-CCD1 complex	Human	None	None	O15169;Q155Q3;Q9Y6R4	8312;85458;4216	MI:0007-anti tag coimmunoprecipitation	GO:0007254	JNK cascade	30.01.05.01.02	JNK cascade	15262978	The authors analyzed that Ccd1 uses its coiled-coil domain to interact with MEKK4 and the DIX domain to interact with Axin, forming a ternary complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Axin-1;Dixin;Mitogen-activated protein kinase kinase kinase 4	AXIN1;DIXDC1;MAP3K4	AXIN;CCD1 KIAA1735;KIAA0213 MAPKKK4 MEKK4 MTK1
1813	MAD1L1 homodimer complex	Human	None	None	Q9Y6D9	8379	MI:0018-two hybrid	GO:0000075;GO:0005813	cell cycle checkpoint signaling;centrosome	10.03.01.03;70.05	cell cycle checkpoints (checkpoints of morphogenesis, DNA-damage,-replication, mitotic phase and spindle);centrosome	9546394	None	None	None	Homo sapiens (Human)	Mitotic spindle assembly checkpoint protein MAD1	MAD1L1	MAD1 TXBP181
1814	MAD1L1-MAD2L1 complex	Human	None	None	Q13257;Q9Y6D9	4085;8379	MI:0071-molecular sieving	GO:0000075	cell cycle checkpoint signaling	10.03.01.03	cell cycle checkpoints (checkpoints of morphogenesis, DNA-damage,-replication, mitotic phase and spindle)	15694304	The closed Mad2 bound to Mad1 represents a template for the conversion of open Mad2 into closed Mad2 bound to Cdc20.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Mitotic spindle assembly checkpoint protein MAD2A;Mitotic spindle assembly checkpoint protein MAD1	MAD2L1;MAD1L1	MAD2;MAD1 TXBP181
1816	JUN-TCF4-CTNNB1 complex	Human	None	None	P05412;P15884;P35222	3725;6925;1499	MI:0096-pull down	GO:0016055;GO:0023052	Wnt signaling pathway;signaling	30.05.02.20;30.01	Wnt signalling pathway;cellular signalling	16007074	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transcription factor Jun;Transcription factor 4;Catenin beta-1	JUN;TCF4;CTNNB1	None;BHLHB19 ITF2 SEF2;CTNNB
1826	SMAD3-HEF1-APC10-CDH1 complex	Human	None	None	P12830;P84022;Q14511;Q9UM13	999;4088;4739;10393	MI:0007-anti tag coimmunoprecipitation	GO:0043161;GO:0006511;GO:0007179;GO:0005737	proteasome-mediated ubiquitin-dependent protein catabolic process;ubiquitin-dependent protein catabolic process;transforming growth factor beta receptor signaling pathway;cytoplasm	14.13.01.01;30.05.01.18.01;70.03	proteasomal degradation (ubiquitin/proteasomal pathway);TGF-beta-receptor signalling pathway;cytoplasm	15144564	SMAD3 regulates the proteosomal degradation of its interacting proteins via recruiting the cell-cycle linked E3 ligase APC. SMAD3 interaction with APC10 is regulated by TGF-beta type I receptor activation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cadherin-1;Mothers against decapentaplegic homolog 3;Enhancer of filamentation 1;Anaphase-promoting complex subunit 10	CDH1;SMAD3;NEDD9;ANAPC10	CDHE UVO;MADH3;CASL;APC10
1827	PML-SMAD2/3-SARA complex	Human	None	None	O95405;P29590;P84022;Q15796	9372;5371;4088;4087	MI:0007-anti tag coimmunoprecipitation	GO:0007179;GO:0005737	transforming growth factor beta receptor signaling pathway;cytoplasm	30.05.01.18.01;70.03	TGF-beta-receptor signalling pathway;cytoplasm	15356634	PML is essential for the formation of a stable and functional SARA-SMAD2/3complex. PML may function as a bridging factor between SARA and SMAD2/3.	Promyelocytic leukaemia	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Zinc finger FYVE domain-containing protein 9;Protein PML;Mothers against decapentaplegic homolog 3;Mothers against decapentaplegic homolog 2	ZFYVE9;PML;SMAD3;SMAD2	MADHIP SARA SMADIP;MYL PP8675 RNF71 TRIM19;MADH3;MADH2 MADR2
1828	TGF-beta receptor I-Axin-SMAD3 complex	Human	None	HEK293T cells	O15169;P36897;P84022	8312;7046;4088	MI:0007-anti tag coimmunoprecipitation	GO:0005737;GO:0007179	cytoplasm;transforming growth factor beta receptor signaling pathway	70.03;30.05.01.18.01	cytoplasm;TGF-beta-receptor signalling pathway	11438668	Phosphorylation of SMAD3 by TGF-betaRI is faciliated in the presence of Axin. In the absence of ligand stimulation, Axin was colocalized with Smad3 in the cytoplasm in vivo. Upon receptor activation, Smad3 was strongly phosphorylated by TGF-beta type I receptor (TGF-betaRI) in the presence of Axin, and dissociated from TGF-betaRI and Axin.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Axin-1;TGF-beta receptor type-1;Mothers against decapentaplegic homolog 3	AXIN1;TGFBR1;SMAD3	AXIN;ALK5 SKR4;MADH3
1831	PIAS3-SMAD3-P300 complex	Human	None	None	P84022;Q09472;Q9Y6X2	4088;2033;10401	MI:0007-anti tag coimmunoprecipitation	GO:0006265;GO:0045893;GO:0006473;GO:0003677;GO:0007179;GO:0051276;GO:0005634	DNA topological change;positive regulation of DNA-templated transcription;protein acetylation;DNA binding;transforming growth factor beta receptor signaling pathway;chromosome organization;nucleus	10.01.09.05;11.02.03.04.01;14.07.04;16.03.01;30.05.01.18.01;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription activation;modification by acetylation, deacetylation;DNA binding;TGF-beta-receptor signalling pathway;organization of chromosome structure;nucleus	14691252	TGF-beta treatment increases the complex formation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mothers against decapentaplegic homolog 3;Histone acetyltransferase p300;E3 SUMO-protein ligase PIAS3	SMAD3;EP300;PIAS3	MADH3;P300;None
1834	ITGAE-ITGB7-CDH1 complex	Human	integrin complex	None	P12830;P26010;P38570	999;3695;3682	MI:0019-coimmunoprecipitation	GO:0065003	protein-containing complex assembly	None	None	10837471	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cadherin-1;Integrin beta-7;Integrin alpha-E	CDH1;ITGB7;ITGAE	CDHE UVO;None;None
1844	APC-IQGAP1 complex	Human	None	COS cells	P25054;P46940	324;8826	MI:0006-anti bait coimmunoprecipitation;MI:0096-pull down	GO:0016477;GO:0007010;GO:0005856	cell migration;cytoskeleton organization;cytoskeleton	34.05.01;42.04;70.04	cell migration;cytoskeleton/structural proteins;cytoskeleton	15572129	The authors demonstrate that the amount of IQGAP1 is about 20 times more than that of APC, and that the armadillo repeats of APC are responsible for the interaction with IQGAP1.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Adenomatous polyposis coli protein;Ras GTPase-activating-like protein IQGAP1	APC;IQGAP1	DP2.5;KIAA0051
1845	APC-IQGAP1-CLIP-170 complex	Human	None	COS cells	P25054;P30622;P46940	324;6249;8826	MI:0006-anti bait coimmunoprecipitation	GO:0016477;GO:0007010;GO:0005856	cell migration;cytoskeleton organization;cytoskeleton	34.05.01;42.04;70.04	cell migration;cytoskeleton/structural proteins;cytoskeleton	15572129	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Adenomatous polyposis coli protein;CAP-Gly domain-containing linker protein 1;Ras GTPase-activating-like protein IQGAP1	APC;CLIP1;IQGAP1	DP2.5;CYLN1 RSN;KIAA0051
1851	BUB1-BUB3 complex	Human	None	HeLa S3 cells	O43683;O43684	699;9184	MI:0019-coimmunoprecipitation	GO:0006468	protein phosphorylation	14.07.03	modification by phosphorylation, dephosphorylation, autophosphorylation	15525512	Bub1-Bub3 phosphorylated Cdc20. Bub1 alone also efficiently phosphorylatedCdc20, indicating that Bub3 is not required for this process.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Mitotic checkpoint serine/threonine-protein kinase BUB1;Mitotic checkpoint protein BUB3	BUB1;BUB3	BUB1L;None
1863	TSG101-VPS37B-VPS28 complex	Human	None	None	Q99816;Q9H9H4;Q9UK41	7251;79720;51160	MI:0019-coimmunoprecipitation	GO:0006886;GO:0006605;GO:0015031	intracellular protein transport;protein targeting;protein transport	14.04;20.01.10	protein targeting, sorting and translocation;protein transport	15218037	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Tumor susceptibility gene 101 protein;Vacuolar protein sorting-associated protein 37B;Vacuolar protein sorting-associated protein 28 homolog	TSG101;VPS37B;VPS28	None;None;None
1890	ELK1-SRF-ELK4 complex	Human	None	None	P11831;P19419;P28324	6722;2002;2005	MI:0413-electrophoretic mobility shift assay	GO:2001141;GO:0006355	regulation of RNA biosynthetic process;regulation of DNA-templated transcription	11.02.03.04	transcriptional control	7540136	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Serum response factor;ETS domain-containing protein Elk-1;ETS domain-containing protein Elk-4	SRF;ELK1;ELK4	None;;SAP1
1893	mTOR2 complex (MTOR, RICTOR, MLST8)	Human	mTOR complex (MTOR, RICTOR, MLST8)	HEK 293T cells	P42345;Q6R327;Q9BVC4	2475;253260;64223	MI:0006-anti bait coimmunoprecipitation	GO:0000902;GO:0016049;GO:0030036	cell morphogenesis;cell growth;actin cytoskeleton organization	40.01;42.04.03	cell growth / morphogenesis;actin cytoskeleton	15268862	The authors found that the rictor-mTOR complex modulates the phosphorylation of Protein Kinase C alpha (PKCalpha) and the actin cytoskeleton. The rictor-mTOR complex is insensitive to rapamycin.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein kinase mTOR;Rapamycin-insensitive companion of mTOR;Target of rapamycin complex subunit LST8	MTOR;RICTOR;MLST8	FRAP FRAP1 FRAP2 RAFT1 RAPT1;KIAA1999;GBL, LST8
1899	NTF4 homodimer complex	Human	None	None	P34130	4909	MI:0114-x-ray crystallography	GO:0030182	neuron differentiation	43.03.13	neuron	10631974	The structures of the neurotrophin homodimers reveals common features that may be important in the binding between the neurotrophins and their receptors.	None	None	Homo sapiens (Human)	Neurotrophin-4	NTF4	NTF5
1909	APC-DLG4 complex	Human	None	None	P25054;P78352	324;1742	MI:0019-coimmunoprecipitation	GO:0016477;GO:0000902;GO:0016049	cell migration;cell morphogenesis;cell growth	34.05.01;40.01	cell migration;cell growth / morphogenesis	9326658	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Adenomatous polyposis coli protein;Disks large homolog 4	APC;DLG4	DP2.5;PSD95
1927	PKD2-PACS1 complex	Human	None	None	Q13563;Q6VY07	5311;55690	MI:0019-coimmunoprecipitation	GO:0005216	ion channel activity	20.03.01.01	ion channels	15692563	None	Mutations of PKD2, a member of the TRP family of cation channels, cause autosomal dominant polycystic kidney disease.	None	Homo sapiens (Human);Homo sapiens (Human)	Polycystin-2;Phosphofurin acidic cluster sorting protein 1	PKD2;PACS1	TRPP2;KIAA1175
1932	NEK2-NEK11 complex	Human	None	None	P51955;Q8NG66	4751;79858	MI:0019-coimmunoprecipitation	GO:0051726	regulation of cell cycle	10.03.01	mitotic cell cycle and cell cycle control	15161910	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein kinase Nek2;Serine/threonine-protein kinase Nek11	NEK2;NEK11	NEK2A NLK1;None
1944	IRAK1-IRAK2 complex	Human	None	None	O43187;P51617	3656;3654	MI:0019-coimmunoprecipitation	GO:0045087	innate immune response	36.25.16.01	innate immune response (invertebrates and vertebrates)	10383454	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Interleukin-1 receptor-associated kinase-like 2;Interleukin-1 receptor-associated kinase 1	IRAK2;IRAK1	None;IRAK
1945	IRAK1-IRAK3 complex	Human	None	None	P51617;Q9Y616	3654;11213	MI:0019-coimmunoprecipitation	GO:0045087	innate immune response	36.25.16.01	innate immune response (invertebrates and vertebrates)	10383454	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Interleukin-1 receptor-associated kinase 1;Interleukin-1 receptor-associated kinase 3	IRAK1;IRAK3	IRAK;None
1957	DAP12 signaling homodimer complex	Human	None	None	O43914	7305	MI:0019-coimmunoprecipitation	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	30.05.01.12	transmembrane receptor protein tyrosine kinase signalling pathways	15845448	None	None	None	Homo sapiens (Human)	TYRO protein tyrosine kinase-binding protein	TYROBP	DAP12 KARAP
1970	BMP4-TWSG1 complex	Human	None	None	P12644;Q9GZX9	652;57045	MI:0019-coimmunoprecipitation	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	30.05.01.18	transmembrane receptor protein serine/threonine kinase signalling pathways	15775969	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Bone morphogenetic protein 4;Twisted gastrulation protein homolog 1	BMP4;TWSG1	BMP2B DVR4;TSG
1972	BMP4-BGN complex	Human	None	None	P12644;P21810	652;633	MI:0019-coimmunoprecipitation	GO:0023052	signaling	30.01	cellular signalling	15775969	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Bone morphogenetic protein 4;Biglycan	BMP4;BGN	BMP2B DVR4;SLRR1A
1976	MTNR1A homodimer complex	Human	None	None	P48039	4543	MI:0019-coimmunoprecipitation	GO:0008502	melatonin receptor activity	None	None	15266022	None	None	None	Homo sapiens (Human)	Melatonin receptor type 1A	MTNR1A	None
1977	MTNR1B homodimer complex	Human	None	None	P49286	4544	MI:0012-bioluminescence resonance energy transfer;MI:0019-coimmunoprecipitation	GO:0008502	melatonin receptor activity	None	None	15266022	None	None	None	Homo sapiens (Human)	Melatonin receptor type 1B	MTNR1B	None
1982	CACY homodimer  complex	Human	None	None	P06703	6277	MI:0027-cosedimentation	GO:0005509;GO:0008270	calcium ion binding;zinc ion binding	16.17.01	calcium binding	9578461	None	None	None	Homo sapiens (Human)	Protein S100-A6	S100A6	CACY
1984	PEX14 homodimer complex	Human	None	None	O75381	5195	MI:0018-two hybrid;MI:0030-cross-linking study	GO:0007031;GO:0005777;GO:0065003	peroxisome organization;peroxisome;protein-containing complex assembly	42.19;70.19	peroxisome;peroxisome	12096124	None	None	None	Homo sapiens (Human)	Peroxisomal membrane protein PEX14	PEX14	None
1985	AIRE homodimer complex	Human	None	None	O43918	326	MI:0018-two hybrid;MI:0019-coimmunoprecipitation	GO:0045893	positive regulation of DNA-templated transcription	11.02.03.04.01	transcription activation	10748110	None	Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy is caused by mutations in the autoimmune regulator (AIRE) gene.	None	Homo sapiens (Human)	Autoimmune regulator	AIRE	APECED
1986	Endoglin homodimer complex	Human	None	None	P17813	2022	MI:0019-coimmunoprecipitation	GO:0023052	signaling	30.01	cellular signalling	15806144	None	None	None	Homo sapiens (Human)	Endoglin	ENG	END
1987	MYOM1 homodimer complex	Human	None	muscle	P52179	8736	MI:0018-two hybrid;MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0007517	muscle organ development	45.03.12	muscle	15571722	None	None	None	Homo sapiens (Human)	Myomesin-1	MYOM1	None
1989	BANF1 homodimer protein	Human	None	None	O75531	8815	MI:0077-nuclear magnetic resonance	GO:0003677;GO:0009607	DNA binding;response to biotic stimulus	16.03.01;34.11.10	DNA binding;response to biotic stimulus	9783751	None	None	None	Homo sapiens (Human)	Barrier-to-autointegration factor	BANF1	BAF BCRG1
1990	PGRMC1-SCAP complex	Human	None	None	O00264;Q12770	10857;22937	MI:0019-coimmunoprecipitation;MI:0030-cross-linking study	GO:0042632;GO:0005783	cholesterol homeostasis;endoplasmic reticulum	34.01.07;70.07	cholesterol homeostasis;endoplasmic reticulum	15782218	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Membrane-associated progesterone receptor component 1;Sterol regulatory element-binding protein cleavage-activating protein	PGRMC1;SCAP	HPR6.6 PGRMC;KIAA0199
1991	PRMT2 homodimer complex	Human	None	None	P55345	3275	MI:0096-pull down	GO:0030545	signaling receptor regulator activity	18.02.07	regulator of receptor activity	12039952	None	None	None	Homo sapiens (Human)	Protein arginine N-methyltransferase 2	PRMT2	HMT1 HRMT1L1
1992	LEPR homodimer complex	Human	None	None	P48357	3953	MI:0019-coimmunoprecipitation	GO:0005125	cytokine activity	40.02.03.01	cytokines (interleukines, colony stimulating factors, etc.)	9038364	None	None	None	Homo sapiens (Human)	Leptin receptor	LEPR	DB, OBR
1993	SLC1A2 homotrimer complex	Human	None	None	P43004	6506	MI:0030-cross-linking study	GO:0015171;GO:0006865	amino acid transmembrane transporter activity;amino acid transport	20.01.07	amino acid/amino acid derivatives transport	15483603	None	None	None	Homo sapiens (Human)	Excitatory amino acid transporter 2	SLC1A2	EAAT2 GLT1
2001	NOD1 homodimer complex	Human	None	None	Q9Y239	10392	MI:0114-x-ray crystallography	GO:0007249;GO:0006954	I-kappaB kinase/NF-kappaB signaling;inflammatory response	30.01.05.01.04;36.25.16.07	NIK-I-kappaB/NF-kappaB cascade;inflammatory response	18186648	None	None	None	Homo sapiens (Human)	Nucleotide-binding oligomerization domain-containing protein 1	NOD1	CARD4
2003	COX1 homodimer complex	Human	None	None	P23219	5742	MI:0114-x-ray crystallography	GO:0006643;GO:0005737	membrane lipid metabolic process;cytoplasm	01.06.02;70.03	membrane lipid metabolism;cytoplasm	11318639	None	None	None	Homo sapiens (Human)	Prostaglandin G/H synthase 1	PTGS1	COX1
2004	C1D homodimer protein	Human	None	None	Q13901	10438	MI:0019-coimmunoprecipitation	GO:0065003	protein-containing complex assembly	None	None	11801738	Only the dimeric but not the monomeric form of C1D can interact with TRAX protein. The finding that the SDS-resistant homodimers of C1D and TRAX interact only after gamma-irradiation may indicate that a post-translational modification is required for the interaction.	None	None	Homo sapiens (Human)	Nuclear nucleic acid-binding protein C1D	C1D	None
2005	PTPRA homodimer complex	Human	None	None	P18433	5786	MI:0030-cross-linking study;MI:0055-fluorescent resonance energy transfer	GO:0007167	enzyme-linked receptor protein signaling pathway	30.05.01	receptor enzyme mediated signalling	11401727	RPTPalpha dimerized constitutively in living cells, which may be mediated by the transmembrane domain, providing strong support for the model that dimerization is involved in regulation of RPTPs.	None	None	Homo sapiens (Human)	Receptor-type tyrosine-protein phosphatase alpha	PTPRA	PTPA PTPRL2
2007	PRNP homo-oligomer complex	Human	None	None	P04156	5621	MI:0276-blue native page	GO:0030182	neuron differentiation	43.03.13	neuron	16148934	The non-fibrillar particles, with masses equivalent to 14-28 PrP molecules, are the most efficient initiators of TSE disease.	None	None	Homo sapiens (Human)	Major prion protein	PRNP	ALTPRP PRIP PRP
2010	AXL homodimer complex	Human	None	None	P30530	558	MI:0018-two hybrid	GO:0007169;GO:0005886	transmembrane receptor protein tyrosine kinase signaling pathway;plasma membrane	30.05.01.12;70.02	transmembrane receptor protein tyrosine kinase signalling pathways;eukaryotic plasma membrane / membrane attached	12470648	None	None	None	Homo sapiens (Human)	Tyrosine-protein kinase receptor UFO	AXL	UFO
2013	STAT5B homodimer complex	Human	None	None	P51692	6777	MI:0413-electrophoretic mobility shift assay	GO:0045893	positive regulation of DNA-templated transcription	11.02.03.04.01	transcription activation	10594041	None	None	None	Homo sapiens (Human)	Signal transducer and activator of transcription 5B	STAT5B	None
2016	IL12A homodimer complex	Human	None	None	P29459	3592	MI:0019-coimmunoprecipitation;MI:0071-molecular sieving	GO:0030217	T cell differentiation	43.03.07.02.01.02	T-cell	7527811	None	None	None	Homo sapiens (Human)	Interleukin-12 subunit alpha	IL12A	NKSF1
2019	IL12A-IL12B-IL12RB1 complex	Human	None	None	P29459;P29460;P42701	3592;3593;3594	MI:0027-cosedimentation;MI:0099-scintillation proximity assay	GO:0023052	signaling	30.01	cellular signalling	9498755	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Interleukin-12 subunit alpha;Interleukin-12 subunit beta;Interleukin-12 receptor subunit beta-1	IL12A;IL12B;IL12RB1	NKSF1;NKSF2;IL12R IL12RB
2020	IL12B-IL12RB1-IL12RB2 complex	Human	None	None	P29460;P42701;Q99665	3593;3594;3595	MI:0019-coimmunoprecipitation	GO:0030217	T cell differentiation	43.03.07.02.01.02	T-cell	7527811	IL12B (p40) homodimer  was capable of competing with IL-12 heterodimer in binding to the IL12R on T cells but was unable to cause cellular proliferation. Furthermore, p40 homodimer inhibited IL-12-induced T cell proliferation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Interleukin-12 subunit beta;Interleukin-12 receptor subunit beta-1;Interleukin-12 receptor subunit beta-2	IL12B;IL12RB1;IL12RB2	NKSF2;IL12R IL12RB;None
2021	IL12A-IL12B-IL12RB2 complex	Human	None	None	P29459;P29460;Q99665	3592;3593;3595	MI:0027-cosedimentation;MI:0099-scintillation proximity assay	GO:0023052	signaling	30.01	cellular signalling	9498755	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Interleukin-12 subunit alpha;Interleukin-12 subunit beta;Interleukin-12 receptor subunit beta-2	IL12A;IL12B;IL12RB2	NKSF1;NKSF2;None
2023	STAT5A homodimer complex	Human	None	None	P42229	6776	MI:0413-electrophoretic mobility shift assay	GO:0045893	positive regulation of DNA-templated transcription	11.02.03.04.01	transcription activation	10594041	None	None	None	Homo sapiens (Human)	Signal transducer and activator of transcription 5A	STAT5A	STAT5
2026	IL-12RB1/B2 receptor-IL-12 complex, high-affinity	Human	Interleukin-12RB1/B2 receptor-interleukin-12 complex; IL12A-IL12B-IL12RB1-IL12RB2 complex	Ba/F3 cells, transfected with human genes	P29459;P29460;P42701;Q99665	3592;3593;3594;3595	MI:0045-experimental interaction detection	GO:0023052;GO:0005886;GO:0019221;GO:0006955;GO:0035722;GO:0042098;GO:0001787;GO:0032609	signaling;plasma membrane;cytokine-mediated signaling pathway;immune response;interleukin-12-mediated signaling pathway;T cell proliferation;natural killer cell proliferation;interferon-gamma production	30.01;70.02;36.25.16	cellular signalling;eukaryotic plasma membrane / membrane attached;immune response	8943050	None	None	IL-12 is a 75-kDa heterodimer composed of disulfide-bonded 40-kDa and 35-kDa subunits. (PMID: 1715362). The isolation of the IL-12 heterodimer has been shown in PMID: 2504877)	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Interleukin-12 subunit alpha;Interleukin-12 subunit beta;Interleukin-12 receptor subunit beta-1;Interleukin-12 receptor subunit beta-2	IL12A;IL12B;IL12RB1;IL12RB2	NKSF1;NKSF2;IL12R IL12RB;None
2028	JAK2-IL12RB2 complex	Human	None	None	O60674;Q99665	3717;3595	MI:0019-coimmunoprecipitation	GO:0023052	signaling	30.01	cellular signalling	9038232	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Tyrosine-protein kinase JAK2;Interleukin-12 receptor subunit beta-2	JAK2;IL12RB2	None;None
2029	BNIP2-ARHGAP8 complex	Human	None	None	P85298;Q12982	23779;663	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0005096;GO:0043547	GTPase activator activity;positive regulation of GTPase activity	18.02.01.01.01	GTPase activator (GAP)	12944407	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Rho GTPase-activating protein 8;BCL2/adenovirus E1B 19 kDa protein-interacting protein 2	ARHGAP8;BNIP2	None;NIP2
2051	MALT1 homo-oligomer complex	Human	None	lymphocyte	Q9UDY8-1	10892	MI:0019-coimmunoprecipitation	GO:0043085;GO:0008047;GO:0051259	positive regulation of catalytic activity;enzyme activator activity;protein complex oligomerization	18.02.01.01	enzyme activator	15125833	TRAF6 ubiquitin ligase and TAK1 protein kinase mediate IKK activation by MALT1 and BCL10 in lymphocytes. Only oligomers of MALT1 and BCL10 can activate IKK in vitro. MALT1 oligomers bind to TRAF6, induce TRAF6 oligomerization, and activate the ligase activity of TRAF6 to polyubiquinate NEMO. These results reveal an oligomerization-ubiquination-phosphorylation cascade that culminates in NF-kappaB activation in T lymphocytes.	None	MALT1 (824 aa) = splice variant/isoform.	Homo sapiens (Human)	Isoform 1 of Mucosa-associated lymphoid tissue lymphoma translocation protein 1	MALT1	MLT
2052	BCL10 homo-oligomer complex	Human	None	lymphocyte	O95999	8915	MI:0019-coimmunoprecipitation	GO:0043085;GO:0008047	positive regulation of catalytic activity;enzyme activator activity	18.02.01.01	enzyme activator	15125833	TRAF6 ubiquitin ligase and TAK1 protein kinase mediate IKK activation by MALT1 and BCL10 in lymphocytes. Only oligomers of MALT1 and BCL10 can activate IKK in vitro.	None	BCL10 (233 aa) = splice variant/isoform.	Homo sapiens (Human)	B-cell lymphoma/leukemia 10	BCL10	CIPER, CLAP
2053	BCL10-MALT1 complex	Human	None	lymphocyte	O95999;Q9UDY8-1	8915;10892	MI:0019-coimmunoprecipitation	GO:0043085;GO:0008047	positive regulation of catalytic activity;enzyme activator activity	18.02.01.01	enzyme activator	15125833	BCL10 binds to the Ig domains of MALT1 and promotes MALT1 oligomerization.	None	MALT1 (824 aa) = splice variant/isoform; BCL10 (233 aa) = splice variant/isoform;	Homo sapiens (Human);Homo sapiens (Human)	B-cell lymphoma/leukemia 10;Isoform 1 of Mucosa-associated lymphoid tissue lymphoma translocation protein 1	BCL10;MALT1	CIPER, CLAP;MLT
2054	CASP8-FADD-MALT1-BCL10 complex	Human	None	Jurkat A3 or I9.2 cells	O95999;Q13158;Q14790;Q9UDY8	8915;8772;841;10892	MI:0019-coimmunoprecipitation	GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	None	None	15746428	The adapter protein FADD associated with caspase-8 and Bcl10-MALT1 at an earlier time (5 min) but disappeared before the recruitment of IKK to form the holocomplex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	B-cell lymphoma/leukemia 10;FAS-associated death domain protein;Caspase-8;Mucosa-associated lymphoid tissue lymphoma translocation protein 1	BCL10;FADD;CASP8;MALT1	CIPER, CLAP;MORT1;MCH5;MLT
2055	CASP8-CHUK-IKBKB-MALT1-BCL10 complex	Human	None	Jurkat A3 or I9.2 cells	O14920;O15111;O95999;Q14790;Q9UDY8	3551;1147;8915;841;10892	MI:0019-coimmunoprecipitation	GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	None	None	15746428	TCR (T cell receptor) stimulation induced caspase-8 to associate with the Bcl10-MALT1 complex followed by recruitment of IKK. Caspase-8 emerges both as a pivotal molecule for death-receptor signaling and as a selective signal transducer for NF-kappaB during the early genetic response to an antigen.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Inhibitor of nuclear factor kappa-B kinase subunit beta;Inhibitor of nuclear factor kappa-B kinase subunit alpha;B-cell lymphoma/leukemia 10;Caspase-8;Mucosa-associated lymphoid tissue lymphoma translocation protein 1	IKBKB;CHUK;BCL10;CASP8;MALT1	IKKB;IKKA TCF16;CIPER, CLAP;MCH5;MLT
2073	TNFRSF11A-TRAF6-SRC complex	Human	None	None	P12931;Q9Y4K3;Q9Y6Q6	6714;7189;8792	MI:0007-anti tag coimmunoprecipitation	GO:0023052	signaling	30.01	cellular signalling	10635328	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Proto-oncogene tyrosine-protein kinase Src;TNF receptor-associated factor 6;Tumor necrosis factor receptor superfamily member 11A	SRC;TRAF6;TNFRSF11A	SRC1;RNF85;RANK
2074	TRAF6 homo-oligomer complex	Human	None	lymphocyte	Q9Y4K3	7189	MI:0019-coimmunoprecipitation	GO:0043085;GO:0008047	positive regulation of catalytic activity;enzyme activator activity	18.02.01.01	enzyme activator	15125833	MALT1 oligomers bind to TRAF6, induce TRAF6 oligomerization, and activate the ligase activity of TRAF6 to polyubiquinate NEMO. These results reveal an oligomerization-ubiquination-phosphorylation cascade that culminates in NF-kappaB activation in T lymphocytes.	None	None	Homo sapiens (Human)	TNF receptor-associated factor 6	TRAF6	RNF85
2077	B-raf-MAP3K11 complex	Human	None	CCD-18Co cells	Q16584;Q9NY11	4296;6635	MI:0019-coimmunoprecipitation	GO:0023052	signaling	30.01	cellular signalling	15258589	MLK3 and B-Raf form a complex in vivo.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Mitogen-activated protein kinase kinase kinase 11;B-Raf protein	MAP3K11;B-raf	MLK3 PTK1 SPRK;None
2084	NFKB1-NFKB2-REL-RELA-RELB complex	Human	None	None	P19838;Q00653;Q01201;Q04206;Q04864	4790;4791;5971;5970;5966	MI:0413-electrophoretic mobility shift assay	GO:2001141;GO:0006355	regulation of RNA biosynthetic process;regulation of DNA-templated transcription	11.02.03.04	transcriptional control	15782119	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Nuclear factor NF-kappa-B p105 subunit;Nuclear factor NF-kappa-B p100 subunit;Transcription factor RelB;Transcription factor p65;Proto-oncogene c-Rel	NFKB1;NFKB2;RELB;RELA;REL	None;LYT10;None;NFKB3;None
2086	NFKB1-NFKB2-RELA-RELB complex	Human	None	None	P19838;Q00653;Q01201;Q04206	4790;4791;5971;5970	MI:0413-electrophoretic mobility shift assay	GO:2001141;GO:0006355	regulation of RNA biosynthetic process;regulation of DNA-templated transcription	11.02.03.04	transcriptional control	15782119	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Nuclear factor NF-kappa-B p105 subunit;Nuclear factor NF-kappa-B p100 subunit;Transcription factor RelB;Transcription factor p65	NFKB1;NFKB2;RELB;RELA	None;LYT10;None;NFKB3
2100	CHUK-IKBKB-MAP3K14 complex	Human	None	None	O14920;O15111;Q99558	3551;1147;9020	MI:0019-coimmunoprecipitation	GO:0030234;GO:0050790	enzyme regulator activity;regulation of catalytic activity	18.02.01	enzymatic activity regulation / enzyme regulator	9346485	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Inhibitor of nuclear factor kappa-B kinase subunit beta;Inhibitor of nuclear factor kappa-B kinase subunit alpha;Mitogen-activated protein kinase kinase kinase 14	IKBKB;CHUK;MAP3K14	IKKB;IKKA TCF16;NIK
2101	CHUK-IKBKB complex	Human	IKKA-IKKB complex; IKK complex	HEK293 cells	O14920;O15111	3551;1147	MI:0006-anti bait coimmunoprecipitation	GO:0034612;GO:0070555;GO:0006468;GO:0045087;GO:0019048;GO:0006954;GO:0008384;GO:0007249;GO:0051090;GO:0051607	response to tumor necrosis factor;response to interleukin-1;protein phosphorylation;innate immune response;modulation by virus of host process;inflammatory response;IkappaB kinase activity;I-kappaB kinase/NF-kappaB signaling;regulation of DNA-binding transcription factor activity;defense response to virus	14.07.03;36.25.16.01;36.25.16.07;30.01.05.01.04;18.02.09	modification by phosphorylation, dephosphorylation, autophosphorylation;innate immune response (invertebrates and vertebrates);inflammatory response;NIK-I-kappaB/NF-kappaB cascade;regulator of transcription factor	9346485	The Tax oncoprotein of human T-cell leukemia virus type 1, the etiologic agent of an aggressive malignancy of activated CD4+ T lymphocytes, associates with IKKA-IKKB complexes leading to chronically activation of the transcription factor NF-kappaB. (PMID:9632633)	None	None	Homo sapiens (Human);Homo sapiens (Human)	Inhibitor of nuclear factor kappa-B kinase subunit beta;Inhibitor of nuclear factor kappa-B kinase subunit alpha	IKBKB;CHUK	IKKB;IKKA TCF16
2104	IKBKB-MAP3K14 complex	Human	IKKB-NIK complex	None	O14920;Q99558	3551;9020	MI:0019-coimmunoprecipitation	GO:0030234;GO:0050790	enzyme regulator activity;regulation of catalytic activity	18.02.01	enzymatic activity regulation / enzyme regulator	9346485	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Inhibitor of nuclear factor kappa-B kinase subunit beta;Mitogen-activated protein kinase kinase kinase 14	IKBKB;MAP3K14	IKKB;NIK
2105	IkappaB kinase complex (IKBKB, CHUK, IKBKAP, NFKBIA, RELA, MAP3K14)	Human	None	None	O14920;O15111;O95163;P25963;Q04206;Q99558	3551;1147;8518;4792;5970;9020	MI:0019-coimmunoprecipitation	GO:0007249;GO:0023052	I-kappaB kinase/NF-kappaB signaling;signaling	30.01.05.01.04;30.01	NIK-I-kappaB/NF-kappaB cascade;cellular signalling	9751059	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Inhibitor of nuclear factor kappa-B kinase subunit beta;Inhibitor of nuclear factor kappa-B kinase subunit alpha;Elongator complex protein 1;NF-kappa-B inhibitor alpha;Transcription factor p65;Mitogen-activated protein kinase kinase kinase 14	IKBKB;CHUK;ELP1;NFKBIA;RELA;MAP3K14	IKKB;IKKA TCF16;IKAP IKBKAP;IKBA MAD3 NFKBI;NFKB3;NIK
2112	CDC37-HSP90AA1-HSP90AB1-MAP3K11 complex	Human	None	None	P07900;P08238;Q16543;Q16584	3320;3326;11140;4296	MI:0004-affinity chromatography technology;MI:0019-coimmunoprecipitation	GO:0030234;GO:0050790	enzyme regulator activity;regulation of catalytic activity	18.02.01	enzymatic activity regulation / enzyme regulator	15001580	MLK3 associates with Hsp90/p50(cdc37) through its catalytic domain in an activity-independent manner.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-beta;Hsp90 co-chaperone Cdc37;Mitogen-activated protein kinase kinase kinase 11	HSP90AA1;HSP90AB1;CDC37;MAP3K11	HSP90A HSPC1 HSPCA;HSP90B HSPC2 HSPCB;CDC37A;MLK3 PTK1 SPRK
2118	CHUK-ERC1-IKBKB-IKBKG complex	Human	None	HeLa cells	O14920;O15111;Q8IUD2;Q9Y6K9	3551;1147;23085;8517	MI:0019-coimmunoprecipitation	GO:0007249	I-kappaB kinase/NF-kappaB signaling	30.01.05.01.04	NIK-I-kappaB/NF-kappaB cascade	15218148	ELKS may contribute an important oligomerization interface to members of the IKK complex as well as to other upstream or downstream regulators of NF-kappaB transcriptional activity, such as I(kappa)B(alpha).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Inhibitor of nuclear factor kappa-B kinase subunit beta;Inhibitor of nuclear factor kappa-B kinase subunit alpha;ELKS/Rab6-interacting/CAST family member 1;NF-kappa-B essential modulator	IKBKB;CHUK;ERC1;IKBKG	IKKB;IKKA TCF16;ELKS KIAA1081 RAB6IP2;FIP3, NEMO
2123	IKBKG homodimer complex	Human	None	None	Q9Y6K9	8517	MI:0018-two hybrid;MI:0030-cross-linking study	GO:0007249	I-kappaB kinase/NF-kappaB signaling	30.01.05.01.04	NIK-I-kappaB/NF-kappaB cascade	12435599	KK-gamma forms homodimer and homotrimer both in vitro and in yeast or mammalian cells through a C-terminal domain comprising amino acids 251-419.	None	None	Homo sapiens (Human)	NF-kappa-B essential modulator	IKBKG	FIP3, NEMO
2124	CHUK-ESR1-NCOA3 complex	Human	IKKA-ER-alpha-AIB1 complex	None	O15111;P03372;Q9Y6Q9	1147;2099;8202	MI:0006-anti bait coimmunoprecipitation;MI:0402-chromatin immunoprecipitation assay	GO:0006355;GO:0006468;GO:0003677;GO:0071391;GO:0030520	regulation of DNA-templated transcription;protein phosphorylation;DNA binding;cellular response to estrogen stimulus;intracellular estrogen receptor signaling pathway	11.02.03.04;14.07.03;16.03.01	transcriptional control;modification by phosphorylation, dephosphorylation, autophosphorylation;DNA binding	15808510	The authors showed that in estradiol-stimulated MCF7 cells, the association of both ER-alpha and AIB1/SRC-3 with IKK-alpha bound to the cyclin D1 promoter was markedly increased in an estrogen-dependent manner. Further siRNA experiments showed that IKK-alpha contributes to the estrogen-mediated phosphorylation of both ER-alpha and AIB1/SRC-3.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Inhibitor of nuclear factor kappa-B kinase subunit alpha;Estrogen receptor;Nuclear receptor coactivator 3	CHUK;ESR1;NCOA3	IKKA TCF16;ESR NR3A1;AIB1 BHLHE42 RAC3 TRAM1
2129	DNAJB2-HSPA8-PSMA3 complex	Human	None	None	P11142;P25686;P25788	3312;3300;5684	MI:0019-coimmunoprecipitation	GO:0006886;GO:0006605;GO:0015031;GO:0043161;GO:0006511	intracellular protein transport;protein targeting;protein transport;proteasome-mediated ubiquitin-dependent protein catabolic process;ubiquitin-dependent protein catabolic process	14.04;20.01.10;14.13.01.01	protein targeting, sorting and translocation;protein transport;proteasomal degradation (ubiquitin/proteasomal pathway)	15936278	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Heat shock cognate 71 kDa protein;DnaJ homolog subfamily B member 2;Proteasome subunit alpha type-3	HSPA8;DNAJB2;PSMA3	HSC70 HSP73 HSPA10;HSJ1 HSPF3;HC8 PSC8
2143	MAP2K5-PRKCI-SQSTM1 complex	Human	None	None	P41743;Q13163;Q13501	5584;5607;8878	MI:0019-coimmunoprecipitation	GO:0035556;GO:0023052	intracellular signal transduction;signaling	30.01	cellular signalling	12813044	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein kinase C iota type;Dual specificity mitogen-activated protein kinase kinase 5;Sequestosome-1	PRKCI;MAP2K5;SQSTM1	DXS1179E;MEK5 MKK5 PRKMK5;ORCA OSIL
2145	HSF1-YWHAE complex	Human	None	None	P62258;Q00613	7531;3297	MI:0004-affinity chromatography technology;MI:0096-pull down	GO:0009408	response to heat	32.01.05	heat shock response	15364926	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	14-3-3 protein epsilon;Heat shock factor protein 1	YWHAE;HSF1	None;HSTF1
2152	ARNT-HLF complex	Human	None	None	P27540;Q16534	405;3131	MI:0019-coimmunoprecipitation	GO:0045893	positive regulation of DNA-templated transcription	11.02.03.04.01	transcription activation	9113979	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Aryl hydrocarbon receptor nuclear translocator;Hepatic leukemia factor	ARNT;HLF	BHLHE2;
2153	ITGAM-ITGB2-CD11 complex	Human	integrin complex	blood cell	P05107;P08962;P11215	3689;967;3684	MI:0019-coimmunoprecipitation	GO:0023052;GO:0007155	signaling;cell adhesion	30.01;34.07	cellular signalling;cell adhesion	8871662	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-2;CD63 antigen;Integrin alpha-M	ITGB2;CD63;ITGAM	CD18 MFI7;MLA1 TSPAN30;CD11B CR3A
2156	YBX1-AKT1 complex	Human	None	None	P31749;P67809	207;4904	MI:0004-affinity chromatography technology;MI:0019-coimmunoprecipitation	GO:0008361;GO:0005634	regulation of cell size;nucleus	40.01.05;70.10	growth regulators / regulation of cell size;nucleus	15806160	None	Akt and YB-1 work together to promote the growth and possibly the development of breast tumors.	None	Homo sapiens (Human);Homo sapiens (Human)	RAC-alpha serine/threonine-protein kinase;Y-box-binding protein 1	AKT1;YBX1	PKB RAC;NSEP1 YB1
2159	AR-AKT-APPL complex	Human	None	None	P10275;P31749;Q9UKG1	367;207;26060	MI:0007-anti tag coimmunoprecipitation	GO:0023052	signaling	30.01	cellular signalling	12621049	The authors  suggest that APPL, Akt, and AR may exist in a complex and Akt may serve as an important bridge factor for the association of APPL with AR. They demonstrated that the APPL\u00b7AR complex was not clearly seen, and that the addition of Akt markedly enhanced APPL\u00b7AR complex formation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Androgen receptor;RAC-alpha serine/threonine-protein kinase;DCC-interacting protein 13-alpha	AR;AKT1;APPL1	DHTR, NR3C4;PKB RAC;APPL DIP13A KIAA1428
2160	AOF2-AR complex	Human	None	None	O60341;P10275	23028;367	MI:0019-coimmunoprecipitation	GO:0045893	positive regulation of DNA-templated transcription	11.02.03.04.01	transcription activation	16079795	The androgen receptor and LSD1 form chromatin-associated complexes in a ligand-dependent manner. LSD1 co-localizes with the androgen receptor in normal human prostate and prostate tumour.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Lysine-specific histone demethylase 1A;Androgen receptor	KDM1A;AR	AOF2 KDM1 KIAA0601 LSD1;DHTR, NR3C4
2162	APPBP1-UBA3 complex	Human	None	None	Q13564;Q8TBC4	8883;9039	MI:0114-x-ray crystallography	GO:0016567	protein ubiquitination	14.07.05	modification by ubiquitination, deubiquitination	12646924	The APPBP1-UBA3 complex initiates NEDD8 conjugation by first catalyzing adenylation of the C terminus of NEDD8 and ultimately catalyzing transfer of NEDD8 to the downstream enzyme in the pathway, Ubc12 (PMID:16275315).	None	None	Homo sapiens (Human);Homo sapiens (Human)	NEDD8-activating enzyme E1 regulatory subunit;NEDD8-activating enzyme E1 catalytic subunit	NAE1;UBA3	APPBP1;UBE1C
2170	Ubiquitin E3 ligase (CDC34, CUL1, RBX1)	Human	None	None	P49427;P62877;Q13616	997;9978;8454	MI:0007-anti tag coimmunoprecipitation	GO:0016567;GO:0043161;GO:0006511	protein ubiquitination;proteasome-mediated ubiquitin-dependent protein catabolic process;ubiquitin-dependent protein catabolic process	14.07.05;14.13.01.01	modification by ubiquitination, deubiquitination;proteasomal degradation (ubiquitin/proteasomal pathway)	11675391	Ubiquitin E3 ligases covalently attach ubiquitin to a lysine residue on a target protein. Polyubiquitination marks proteins for degradation by the proteasome. The conjugation of Nedd8 to the ROC1-CUL1 complex selectively stimulates Cdc34-catalyzed Lys48-linked multiubiquitin chain assembly.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Ubiquitin-conjugating enzyme E2 R1;E3 ubiquitin-protein ligase RBX1;Cullin-1	CDC34;RBX1;CUL1	UBCH3 UBE2R1;RNF75 ROC1;None
2171	Ubiquitin E3 ligase (CHEK1, CUL4A)	Human	None	None	O14757;Q13619	1111;8451	MI:0019-coimmunoprecipitation	GO:0016567;GO:0043161;GO:0006511;GO:0006974;GO:0005634	protein ubiquitination;proteasome-mediated ubiquitin-dependent protein catabolic process;ubiquitin-dependent protein catabolic process;cellular response to DNA damage stimulus;nucleus	14.07.05;14.13.01.01;32.01.09;70.10	modification by ubiquitination, deubiquitination;proteasomal degradation (ubiquitin/proteasomal pathway);DNA damage response;nucleus	16137618	Ubiquitin E3 ligases covalently attach ubiquitin to a lysine residue on a target protein. Polyubiquitination marks proteins for degradation by the proteasome. The Chk1 kinase is a major effector of S phase checkpoint signaling during the cellular response to genotoxic stress. Replicative stress induces the polyubiquitination and degradation of Chk1 in human cells.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein kinase Chk1;Cullin-4A	CHEK1;CUL4A	CHK1;None
2172	Ubiquitin E3 ligase (CDT1, DDB1, CUL4A, RBX1)	Human	None	None	P62877;Q13619;Q16531;Q9H211	9978;8451;1642;81620	MI:0019-coimmunoprecipitation	GO:0016567;GO:0043161;GO:0006511;GO:0006974	protein ubiquitination;proteasome-mediated ubiquitin-dependent protein catabolic process;ubiquitin-dependent protein catabolic process;cellular response to DNA damage stimulus	14.07.05;14.13.01.01;32.01.09	modification by ubiquitination, deubiquitination;proteasomal degradation (ubiquitin/proteasomal pathway);DNA damage response	15448697	Ubiquitin E3 ligases covalently attach ubiquitin to a lysine residue on a target protein. Polyubiquitination marks proteins for degradation by the proteasome. The CDT1-DDB1-CUL4A complex was observed in an investigation of targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase RBX1;Cullin-4A;DNA damage-binding protein 1;DNA replication factor Cdt1	RBX1;CUL4A;DDB1;CDT1	RNF75 ROC1;None;XAP1;None
2174	COP9 signalosome complex	Human	JAB1-containing signalosome (GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7); COP9 complex homolog	HeLa cells; human JU77 mesothelioma cells	P61201;Q13098;Q7L5N1;Q92905;Q99627;Q9BT78;Q9UBW8;Q9UNS2	9318;2873;10980;10987;10920;51138;50813;8533	MI:0047-far western blotting;MI:0091-chromatography technology	GO:0008180;GO:0010387	COP9 signalosome;COP9 signalosome assembly	None	None	9535219	The purified complex is very similar, if not identical, to the plant COP9 complex involved in light-mediated signal transduction. A regulating transcriptional activity is discussed.	None	Since the authors did not specify COP7, we used isoform COPS7A.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	COP9 signalosome complex subunit 2;COP9 signalosome complex subunit 1;COP9 signalosome complex subunit 6;COP9 signalosome complex subunit 5;COP9 signalosome complex subunit 8;COP9 signalosome complex subunit 4;COP9 signalosome complex subunit 7a;COP9 signalosome complex subunit 3	COPS2;GPS1;COPS6;COPS5;COPS8;COPS4;COPS7A;COPS3	CSN2, TRIP15;COPS1, CSN1;CSN6 HVIP;CSN5, JAB1;CSN8;CSN4;CSN7A DERP10;CSN3
2179	CNS-P53 complex	Human	None	None	P04637;P61201;Q13098;Q7L5N1;Q92905;Q99627;Q9BT78;Q9UBW8;Q9UNS2	7157;9318;2873;10980;10987;10920;51138;50813;8533	MI:0040-electron microscopy;MI:0047-far western blotting;MI:0096-pull down	GO:0006886;GO:0006605;GO:0015031	intracellular protein transport;protein targeting;protein transport	14.04;20.01.10	protein targeting, sorting and translocation;protein transport	11285227	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cellular tumor antigen p53;COP9 signalosome complex subunit 2;COP9 signalosome complex subunit 1;COP9 signalosome complex subunit 6;COP9 signalosome complex subunit 5;COP9 signalosome complex subunit 8;COP9 signalosome complex subunit 4;COP9 signalosome complex subunit 7a;COP9 signalosome complex subunit 3	TP53;COPS2;GPS1;COPS6;COPS5;COPS8;COPS4;COPS7A;COPS3	P53;CSN2, TRIP15;COPS1, CSN1;CSN6 HVIP;CSN5, JAB1;CSN8;CSN4;CSN7A DERP10;CSN3
2183	KAISO-NCOR complex	Human	None	HeLa cells	O15379;O60907;O75164;O75376;P52732;Q13227;Q86T24;Q92828;Q9BZK7;Q9UPN9	8841;6907;9682;9611;3832;2874;10009;7464;79718;51592	MI:0047-far western blotting;MI:0069-mass spectrometry studies of complexes	GO:0006265;GO:0045892;GO:0006473;GO:0006476;GO:0003677;GO:0051276;GO:0005634	DNA topological change;negative regulation of DNA-templated transcription;protein acetylation;protein deacetylation;DNA binding;chromosome organization;nucleus	10.01.09.05;11.02.03.04.03;14.07.04;16.03.01;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription repression;modification by acetylation, deacetylation;DNA binding;organization of chromosome structure;nucleus	14527417	In vivo, Kaiso targets the N-CoR complex to the MTA2 gene promoter in a methylation-dependent manner. The authors postulate that deacetylation of chromatin stabilizes the association of Kaiso-N-CoR with chromatin.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone deacetylase 3;F-box-like/WD repeat-containing protein TBL1X;Lysine-specific demethylase 4A;Nuclear receptor corepressor 1;Kinesin-like protein KIF11;G protein pathway suppressor 2;Transcriptional regulator Kaiso;Coronin-2A;F-box-like/WD repeat-containing protein TBL1XR1;E3 ubiquitin-protein ligase TRIM33	HDAC3;TBL1X;KDM4A;NCOR1;KIF11;GPS2;ZBTB33;CORO2A;TBL1XR1;TRIM33	None;TBL1;JHDM3A JMJD2 JMJD2A KIAA0677;KIAA1047;EG5 KNSL1 TRIP5;None;KAISO ZNF348;IR10 WDR2;IRA1 TBLR1;KIAA1113 RFG7 TIF1G
2188	Ubiquitin E3 ligase (CDC34, NEDD8, BTRC, CUL1, SKP1A, RBX1)	Human	None	None	P62877;P63208;Q13616;Q15843;Q9Y297	9978;6500;8454;4738;8945	MI:0007-anti tag coimmunoprecipitation	GO:0016567;GO:0043161;GO:0006511;GO:0005737	protein ubiquitination;proteasome-mediated ubiquitin-dependent protein catabolic process;ubiquitin-dependent protein catabolic process;cytoplasm	14.07.05;14.13.01.01;70.03	modification by ubiquitination, deubiquitination;proteasomal degradation (ubiquitin/proteasomal pathway);cytoplasm	10713156	Ubiquitin E3 ligases covalently attach ubiquitin to a lysine residue on a target protein. Polyubiquitination marks proteins for degradation by the proteasome. Regulation of NF-kappaB occurs through phosphorylation-dependent ubiquitination of IkappaBalpha, which is degraded by the 26S proteasome. Recent studies have shown that ubiquitination of IkappaBalpha is carried out by ubiquitin E3 ligase complexes. Nedd8 modification of the Cul-1 component of ubiquitin E3 ligases is important for ubiquitination of IkappaBalpha.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase RBX1;S-phase kinase-associated protein 1;Cullin-1;NEDD8;F-box/WD repeat-containing protein 1A	RBX1;SKP1;CUL1;NEDD8;BTRC	RNF75 ROC1;EMC19 OCP2 SKP1A TCEB1L;None;None;BTRCP FBW1A FBXW1A
2189	Ubiquitin E3 ligase (SMAD3, BTRC, CUL1, SKP1A, RBX1)	Human	ROC1-SCFFbw1a	None	P62877;P63208;P84022;Q13616;Q9Y297	9978;6500;4088;8454;8945	MI:0019-coimmunoprecipitation	GO:0016567;GO:0043161;GO:0006511;GO:0023052;GO:0005737;GO:0005634	protein ubiquitination;proteasome-mediated ubiquitin-dependent protein catabolic process;ubiquitin-dependent protein catabolic process;signaling;cytoplasm;nucleus	14.07.05;14.13.01.01;30.01;70.03;70.10	modification by ubiquitination, deubiquitination;proteasomal degradation (ubiquitin/proteasomal pathway);cellular signalling;cytoplasm;nucleus	11359933	Ubiquitin E3 ligases covalently attach ubiquitin to a lysine residue on a target protein. Polyubiquitination marks proteins for degradation by the proteasome. Ubiquitin E3 ligase complex ROC1-SCFFbw1a interacts with activated Smad3 through its MH2 domain and induces the ubiquitination and proteasomal degradation of the transcriptional modulator Smad3.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase RBX1;S-phase kinase-associated protein 1;Mothers against decapentaplegic homolog 3;Cullin-1;F-box/WD repeat-containing protein 1A	RBX1;SKP1;SMAD3;CUL1;BTRC	RNF75 ROC1;EMC19 OCP2 SKP1A TCEB1L;MADH3;None;BTRCP FBW1A FBXW1A
2191	Ubiquitin E3 ligase (FBXO18, SKP1A, CUL1, RBX1)	Human	SCFhFBH1 complex	HEK293 cells	P62877;P63208;Q13616;Q8NFZ0	9978;6500;8454;84893	MI:0007-anti tag coimmunoprecipitation	GO:0006511	ubiquitin-dependent protein catabolic process	14.13.01.01	proteasomal degradation (ubiquitin/proteasomal pathway)	11956208	Ubiquitin E3 ligases covalently attach ubiquitin to a lysine residue on a target protein. Polyubiquitination marks proteins for degradation by the proteasome. hFBH1 is the first F-box protein implicated in nucleic acid metabolism.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase RBX1;S-phase kinase-associated protein 1;Cullin-1;F-box DNA helicase 1	RBX1;SKP1;CUL1;FBH1	RNF75 ROC1;EMC19 OCP2 SKP1A TCEB1L;None;FBX18 FBXO18
2192	Ubiquitin E3 ligase (NIPA, SKP1A, CUL1, RBX1)	Human	SCF(NIPA)	None	P62877;P63208;Q13616;Q86WB0	9978;6500;8454;51530	MI:0007-anti tag coimmunoprecipitation	GO:0000278;GO:0016567;GO:0043161;GO:0006511;GO:0005634	mitotic cell cycle;protein ubiquitination;proteasome-mediated ubiquitin-dependent protein catabolic process;ubiquitin-dependent protein catabolic process;nucleus	10.03.01.01;14.07.05;14.13.01.01;70.10	mitotic cell cycle;modification by ubiquitination, deubiquitination;proteasomal degradation (ubiquitin/proteasomal pathway);nucleus	16009132	Ubiquitin E3 ligases covalently attach ubiquitin to a lysine residue on a target protein. Polyubiquitination marks proteins for degradation by the proteasome. Activity of ubiquitin E3 ligase (containing NIPA, SKP1A, CUL1 and RBX1) oscillates throughout the cell cycle, and cell-cycle-regulated phosphorylation of NIPA constitutes the responsible timing circuit. Nuclear cyclin B1 was identified to be a critical substrate of the complex in interphase. According to the oscillating activity of ubiquitin E3 ligase (containing NIPA, SKP1A, CUL1 and RBX1), this targeting process is terminated at G2/M to allow for nuclear cyclin B1 accumulation, which is necessary for mitotic entry.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase RBX1;S-phase kinase-associated protein 1;Cullin-1;Zinc finger C3HC-type protein 1	RBX1;SKP1;CUL1;ZC3HC1	RNF75 ROC1;EMC19 OCP2 SKP1A TCEB1L;None;NIPA
2196	9-1-1-LIG1 complex	Human	LIG1-9-1-1 complex	None	O60671;O60921;P18858;Q99638	5810;3364;3978;5883	MI:0007-anti tag coimmunoprecipitation	GO:0006281;GO:0000075;GO:0006974;GO:0005634	DNA repair;cell cycle checkpoint signaling;cellular response to DNA damage stimulus;nucleus	10.01.05.01;10.03.01.03;32.01.09;70.10	DNA repair;cell cycle checkpoints (checkpoints of morphogenesis, DNA-damage,-replication, mitotic phase and spindle);DNA damage response;nucleus	15871698	The 9-1-1 complex can stimulate DNA ligase I.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cell cycle checkpoint protein RAD1;Checkpoint protein HUS1;DNA ligase 1;Cell cycle checkpoint control protein RAD9A	RAD1;HUS1;LIG1;RAD9A	REC1;None;None;None
2197	9-1-1-FEN1 complex	Human	FEN1-9-1-1 complex	HeLa cells	O60671;O60921;P39748;Q99638	5810;3364;2237;5883	MI:0006-anti bait coimmunoprecipitation	GO:0006308;GO:0006281;GO:0006974;GO:0005634;GO:0140612;GO:0000077	DNA catabolic process;DNA repair;cellular response to DNA damage stimulus;nucleus;DNA damage sensor activity;DNA damage checkpoint signaling	01.03.16.03;10.01.05.01;32.01.09;70.10	DNA degradation;DNA repair;DNA damage response;nucleus	15556996	The 9-1-1 complex is a damage-specific activator of FEN1 activity. (PMID:15556996)	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cell cycle checkpoint protein RAD1;Checkpoint protein HUS1;Flap endonuclease 1;Cell cycle checkpoint control protein RAD9A	RAD1;HUS1;FEN1;RAD9A	REC1;None;RAD2;None
2198	9-1-1-POLB complex	Human	RAD9-RAD1-HUS1-POLB complex	None	O60671;O60921;P06746;Q99638	5810;3364;5423;5883	MI:0007-anti tag coimmunoprecipitation	GO:0006281;GO:0000075;GO:0006974;GO:0005634	DNA repair;cell cycle checkpoint signaling;cellular response to DNA damage stimulus;nucleus	10.01.05.01;10.03.01.03;32.01.09;70.10	DNA repair;cell cycle checkpoints (checkpoints of morphogenesis, DNA-damage,-replication, mitotic phase and spindle);DNA damage response;nucleus	15314187	The 9-1-1 complex directly interacts with and stimulates POLB activity thus recruiting POLB to DNA damage sites.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cell cycle checkpoint protein RAD1;Checkpoint protein HUS1;DNA polymerase beta;Cell cycle checkpoint control protein RAD9A	RAD1;HUS1;POLB;RAD9A	REC1;None;None;None
2199	CHTF18-RFC2-5 complex	Human	CTF18-RFC subcomplex	HEK293T cells	P35249;P35250;P40937;P40938;Q8WVB6	5984;5982;5985;5983;63922	MI:0007-anti tag coimmunoprecipitation	GO:0006260;GO:0007059;GO:0005634;GO:0003677;GO:0016887	DNA replication;chromosome segregation;nucleus;DNA binding;ATP hydrolysis activity	10.01.03;10.03.04.05;70.10;16.03.01	DNA synthesis and replication;chromosome segregation/division;nucleus;DNA binding	12930902	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Replication factor C subunit 4;Replication factor C subunit 2;Replication factor C subunit 5;Replication factor C subunit 3;Chromosome transmission fidelity protein 18 homolog	RFC4;RFC2;RFC5;RFC3;CHTF18	None;None;None;None;C16orf41 CTF18
2200	RFC2-5 subcomplex	Human	None	None	P35249;P35250;P40937;P40938	5984;5982;5985;5983	MI:0029-cosedimentation through density gradient	GO:0006260;GO:0003677;GO:0005634;GO:0016887	DNA replication;DNA binding;nucleus;ATP hydrolysis activity	10.01.03;16.03.01;70.10	DNA synthesis and replication;DNA binding;nucleus	9488738	Reconstitution experiments have revealed that a minimum of three subunits (the 40-, 37-, and 36-kDa subunits) are required for DNA-dependent ATPase activity in vitro.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Replication factor C subunit 4;Replication factor C subunit 2;Replication factor C subunit 5;Replication factor C subunit 3	RFC4;RFC2;RFC5;RFC3	None;None;None;None
2201	PCNA-RFC2-5 complex	Human	None	None	P12004;P35249;P35250;P40937;P40938	5111;5984;5982;5985;5983	MI:0007-anti tag coimmunoprecipitation	GO:0006260;GO:0005634	DNA replication;nucleus	10.01.03;70.10	DNA synthesis and replication;nucleus	12171929	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Proliferating cell nuclear antigen;Replication factor C subunit 4;Replication factor C subunit 2;Replication factor C subunit 5;Replication factor C subunit 3	PCNA;RFC4;RFC2;RFC5;RFC3	None;None;None;None;None
2203	BRD4-RFC complex	Human	None	HeLa cells	O60885;P35249;P35250;P35251;P40937;P40938	23476;5984;5982;5981;5985;5983	MI:0007-anti tag coimmunoprecipitation	GO:0000278;GO:0051726;GO:0000082;GO:0005634	mitotic cell cycle;regulation of cell cycle;G1/S transition of mitotic cell cycle;nucleus	10.03.01.01;10.03.01;10.03.01.01.03;70.10	mitotic cell cycle;mitotic cell cycle and cell cycle control;G1/S transition of mitotic cell cycle;nucleus	12192049	BRD4 regulates cell cycle progression from G1 to S phase by interacting with RFC1.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Bromodomain-containing protein 4;Replication factor C subunit 4;Replication factor C subunit 2;Replication factor C subunit 1;Replication factor C subunit 5;Replication factor C subunit 3	BRD4;RFC4;RFC2;RFC1;RFC5;RFC3	HUNK1;None;None;RFC140;None;None
2204	MCM8-ORC2-CDC6 complex	Human	None	None	Q13416;Q99741;Q9UJA3	4999;990;84515	MI:0019-coimmunoprecipitation	GO:0006260;GO:0000082;GO:0005634	DNA replication;G1/S transition of mitotic cell cycle;nucleus	10.01.03;10.03.01.01.03;70.10	DNA synthesis and replication;G1/S transition of mitotic cell cycle;nucleus	15684404	Down-regulation of MCM8 impairs the G1-to-S transition.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Origin recognition complex subunit 2;Cell division control protein 6 homolog;DNA helicase MCM8	ORC2;CDC6;MCM8	ORC2L;CDC18L;C20orf154
2205	ORC5-ORC1 complex	Human	None	None	O43913;Q13415	5001;4998	MI:0006-anti bait coimmunoprecipitation	GO:0006267;GO:0003688;GO:0005634	pre-replicative complex assembly involved in nuclear cell cycle DNA replication;DNA replication origin binding;nucleus	10.01.03.03;70.10	ori recognition and priming complex formation;nucleus	15448696	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Origin recognition complex subunit 5;Origin recognition complex subunit 1	ORC5;ORC1	ORC5L;ORC1L PARC1
2210	BRCA1-IRIS-pre-replication complex	Human	None	None	O75496;P38398;Q13415;Q99741	51053;672;4998;990	MI:0006-anti bait coimmunoprecipitation;MI:0402-chromatin immunoprecipitation assay	GO:0006260;GO:0005634	DNA replication;nucleus	10.01.03;70.10	DNA synthesis and replication;nucleus	15448696	BRCA1-IRIS is a BRCA1 gene product encoded by an uninterrupted open reading frame that extends from codon 1 of the known BRCA1 open reading frame to a termination point 34 triplets into intron 11. BRCA1-IRIS localizes to the nucleus and fails to interact with BARD1.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Geminin;Breast cancer type 1 susceptibility protein;Origin recognition complex subunit 1;Cell division control protein 6 homolog	GMNN;BRCA1;ORC1;CDC6	None;RNF53;ORC1L PARC1;CDC18L
2211	BARD1-BRCA1-CSTF complex	Human	None	None	P33240;P38398;Q05048;Q12996;Q99728	1478;672;1477;1479;580	MI:0006-anti bait coimmunoprecipitation	GO:0031123;GO:0031124;GO:0003723;GO:0005634	RNA 3'-end processing;mRNA 3'-end processing;RNA binding;nucleus	11.04.03.05;16.03.03;70.10	3'-end processing;RNA binding;nucleus	10477523	Interaction of BARD1 with CstF inhibits RNA polyadenylation and ensures that at DNA damage sites nascent RNAs are not erroneously polyadenylated.	BRCA1 is involved in breast cancer.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cleavage stimulation factor subunit 2;Breast cancer type 1 susceptibility protein;Cleavage stimulation factor subunit 1;Cleavage stimulation factor subunit 3;BRCA1-associated RING domain protein 1	CSTF2;BRCA1;CSTF1;CSTF3;BARD1	None;RNF53;None;None;None
2213	BRCA1-BARD1-POLR2A complex	Human	None	None	P24928;P38398;Q99728	5430;672;580	MI:0019-coimmunoprecipitation	GO:2001141;GO:0006355;GO:0016567;GO:0005634	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;protein ubiquitination;nucleus	11.02.03.04;14.07.05;70.10	transcriptional control;modification by ubiquitination, deubiquitination;nucleus	15886201	BRCA1 and BARD1 heterodimer ubiquitinates a hyperphosphorylated form of POLR2A.	BRCA1 is involved in breast cancer.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA-directed RNA polymerase II subunit RPB1;Breast cancer type 1 susceptibility protein;BRCA1-associated RING domain protein 1	POLR2A;BRCA1;BARD1	POLR2;RNF53;None
2214	LMO4-BRCA1-CTIP-LDB1 complex	Human	None	None	P38398;P61968;Q86U70;Q99708	672;8543;8861;5932	MI:0006-anti bait coimmunoprecipitation	GO:2001141;GO:0006355;GO:0003677;GO:0005634	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;DNA binding;nucleus	11.02.03.04;16.03.01;70.10	transcriptional control;DNA binding;nucleus	11751867	None	BRCA1 is involved in breast cancer.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Breast cancer type 1 susceptibility protein;LIM domain transcription factor LMO4;LIM domain-binding protein 1;DNA endonuclease RBBP8	BRCA1;LMO4;LDB1;RBBP8	RNF53;None;CLIM2;CTIP
2215	BRCA1-LMO4-CTIP complex	Human	None	None	P38398;P61968;Q99708	672;8543;5932	MI:0007-anti tag coimmunoprecipitation	GO:2001141;GO:0006355;GO:0003677;GO:0005634	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;DNA binding;nucleus	11.02.03.04;16.03.01;70.10	transcriptional control;DNA binding;nucleus	11751867	LMO4 functions as a repressor of BRCA1 activity in breast tissue.	BRCA1 is involved in breast cancer.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Breast cancer type 1 susceptibility protein;LIM domain transcription factor LMO4;DNA endonuclease RBBP8	BRCA1;LMO4;RBBP8	RNF53;None;CTIP
2217	MDC1-MRN-ATM-FANCD2 complex	Human	None	None	O60934;P49959;Q13315;Q14676;Q92878;Q9BXW9	4683;4361;472;9656;10111;2177	MI:0006-anti bait coimmunoprecipitation	GO:0006281;GO:0000075;GO:0003677;GO:0006974;GO:0005634	DNA repair;cell cycle checkpoint signaling;DNA binding;cellular response to DNA damage stimulus;nucleus	10.01.05.01;10.03.01.03;16.03.01;32.01.09;70.10	DNA repair;cell cycle checkpoints (checkpoints of morphogenesis, DNA-damage,-replication, mitotic phase and spindle);DNA binding;DNA damage response;nucleus	12607005	Prior exposure of cells to irradiation appears to reduce the interaction of MDC1 with ATM and FANCD2.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Nibrin;Double-strand break repair protein MRE11;Serine-protein kinase ATM;Mediator of DNA damage checkpoint protein 1;DNA repair protein RAD50;Fanconi anemia group D2 protein	NBN;MRE11;ATM;MDC1;RAD50;FANCD2	NBS NBS1 P95;HNGS1 MRE11A;None;KIAA0170 NFBD1;None;FACD
2218	MDC1-MRE11-RAD50-NBS1 complex	Human	None	None	O60934;P49959;Q14676;Q92878	4683;4361;9656;10111	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0006281;GO:0000075;GO:0006974;GO:0005634	DNA repair;cell cycle checkpoint signaling;cellular response to DNA damage stimulus;nucleus	10.01.05.01;10.03.01.03;32.01.09;70.10	DNA repair;cell cycle checkpoints (checkpoints of morphogenesis, DNA-damage,-replication, mitotic phase and spindle);DNA damage response;nucleus	12607003	In response to ionizing radiation, MDC1 is hyperphosphorylated and rapidly relocalizes to nuclear foci that also contain the MRE11 complex. MDC1-mediated focus formation by the MRE11 complex at sites of DNA damage is crucial for the efficient activation of the intra-S-phase checkpoint.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Nibrin;Double-strand break repair protein MRE11;Mediator of DNA damage checkpoint protein 1;DNA repair protein RAD50	NBN;MRE11;MDC1;RAD50	NBS NBS1 P95;HNGS1 MRE11A;KIAA0170 NFBD1;None
2219	TERF1 homodimer complex	Human	None	None	P54274	7013	MI:0413-electrophoretic mobility shift assay	GO:0000278;GO:0051726;GO:0003677;GO:0051276	mitotic cell cycle;regulation of cell cycle;DNA binding;chromosome organization	10.03.01.01;10.03.01;16.03.01;42.10.03	mitotic cell cycle;mitotic cell cycle and cell cycle control;DNA binding;organization of chromosome structure	9391075	TERF1 is shown to be important in regulating telomere length. It may connect mitotic control to the telomere regulatory machinery.	None	None	Homo sapiens (Human)	Telomeric repeat-binding factor 1	TERF1	PIN2 TRBF1 TRF TRF1
2220	RAD52-ERCC4-ERCC1 complex	Human	None	None	P07992;P43351;Q92889	2067;5893;2072	MI:0004-affinity chromatography technology;MI:0006-anti bait coimmunoprecipitation	GO:0006308;GO:0006310;GO:0006281;GO:0005634	DNA catabolic process;DNA recombination;DNA repair;nucleus	01.03.16.03;10.01.05.03;10.01.05.01;70.10	DNA degradation;DNA recombination;DNA repair;nucleus	14734547	Rad52-XPF-ERCC1 complex processes recombination intermediates generated during the repair of DNA double strand breaks.	ERCC4 is involved in xeroderma pigmentosum group F.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA excision repair protein ERCC-1;DNA repair protein RAD52 homolog;DNA repair endonuclease XPF	ERCC1;RAD52;ERCC4	None;;ERCC11 XPF
2223	BLM-TOP3A complex	Human	None	None	P54132;Q13472	641;7156	MI:0006-anti bait coimmunoprecipitation	GO:0051276;GO:0005634	chromosome organization;nucleus	42.10.03;70.10	organization of chromosome structure;nucleus	10734115	None	BLM is involved in Bloom syndrome (BS).	None	Homo sapiens (Human);Homo sapiens (Human)	RecQ-like DNA helicase BLM;DNA topoisomerase 3-alpha	BLM;TOP3A	RECQ2 RECQL3;TOP3
2224	MSH2/6-BLM-p53-RAD51 complex	Human	None	None	P04637;P43246;P52701;P54132;Q06609	7157;4436;2956;641;5888	MI:0006-anti bait coimmunoprecipitation	GO:0006281;GO:0006974;GO:0005634	DNA repair;cellular response to DNA damage stimulus;nucleus	10.01.05.01;32.01.09;70.10	DNA repair;DNA damage response;nucleus	15064730	MSH2/6 protein complex stimulates the ability of the Bloom's syndrome gene product, BLM, to process Holliday junctions in vitro, an activity that could also be regulated by p53. MSH6 colocalizes with BLM and p53 in hydroxyurea-induced RAD51 nuclear foci.	BLM is involved in Bloom's syndrome.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cellular tumor antigen p53;DNA mismatch repair protein Msh2;DNA mismatch repair protein Msh6;RecQ-like DNA helicase BLM;DNA repair protein RAD51 homolog 1	TP53;MSH2;MSH6;BLM;RAD51	P53;None;GTBP;RECQ2 RECQL3;RAD51A RECA
2226	MutS-alpha-PK-zeta complex	Human	None	None	P43246;P52701;Q05513	4436;2956;5590	MI:0006-anti bait coimmunoprecipitation	GO:0006281;GO:0043161;GO:0006511	DNA repair;proteasome-mediated ubiquitin-dependent protein catabolic process;ubiquitin-dependent protein catabolic process	10.01.05.01;14.13.01.01	DNA repair;proteasomal degradation (ubiquitin/proteasomal pathway)	15808853	PKC zeta protects MutS-alpha protein complex from degradation. PKC zeta interacts with hMSH2 and hMSH6 proteins and phosphorylates both.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA mismatch repair protein Msh2;DNA mismatch repair protein Msh6;Protein kinase C zeta type	MSH2;MSH6;PRKCZ	None;GTBP;PKC2
2228	BLM-RAD51L3-XRCC2 complex	Human	None	None	O43543;O75771;P54132	7516;5892;641	MI:0006-anti bait coimmunoprecipitation	GO:0006281;GO:0005634	DNA repair;nucleus	10.01.05.01;70.10	DNA repair;nucleus	12975363	Interaction between BLM and RAD51L3 is mediated through the N-terminal domain of BLM. RAD51L3-XRCC2 complex stimulates ability of BLM to disrupt Holliday junction structures.	BLM is involved in Bloom's syndrome (BS).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA repair protein XRCC2;DNA repair protein RAD51 homolog 4;RecQ-like DNA helicase BLM	XRCC2;RAD51D;BLM	None;RAD51L3;RECQ2 RECQL3
2231	PCNA homotrimer complex	Human	None	None	P12004	5111	MI:0006-anti bait coimmunoprecipitation;MI:0029-cosedimentation through density gradient;MI:0071-molecular sieving	GO:0006260;GO:0005634	DNA replication;nucleus	10.01.03;70.10	DNA synthesis and replication;nucleus	7522248	PCNA exists mainly as homotrimer whose expression increases in the late G1- to S-phase of cell cycle.	PCNA is a target for autoimmunity in systemic lupus erythematosus.	None	Homo sapiens (Human)	Proliferating cell nuclear antigen	PCNA	None
2233	Replication-coupled CAF-1-MBD1-ETDB1 complex	Human	None	None	Q13111;Q15047;Q9UIS9	10036;9869;4152	MI:0006-anti bait coimmunoprecipitation;MI:0018-two hybrid	GO:0006260;GO:0006265;GO:0006349;GO:0000084;GO:0006479;GO:0051276;GO:0005634	DNA replication;DNA topological change;regulation of gene expression by genomic imprinting;mitotic S phase;protein methylation;chromosome organization;nucleus	10.01.03;10.01.09.05;10.01.09.07;10.03.01.01.05;14.07.09;42.10.03;70.10	DNA synthesis and replication;DNA conformation modification (e.g. chromatin);DNA imprinting and other epigenetic effects;S phase of mitotic cell cycle;posttranslational modification of amino acids (e.g. hydroxylation, methylation);organization of chromosome structure;nucleus	15327775	Formation of CAF-1-MBD1-SETDB1 complex occurs during S phase of cell cycle. This complex facilitates methylation of H3-K9 during replication-coupled chromatin assembly.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Chromatin assembly factor 1 subunit A;Histone-lysine N-methyltransferase SETDB1;Methyl-CpG-binding domain protein 1	CHAF1A;SETDB1;MBD1	CAF CAF1P150;ESET KIAA0067 KMT1E;CXXC3 PCM1
2235	ASF1-interacting protein complex	Human	None	None	P54198;P68431;Q13111;Q13112;Q9NVP2;Q9Y294	7290;None;10036;8208;55723;25842	MI:0019-coimmunoprecipitation	GO:0006260;GO:0006265;GO:0051276	DNA replication;DNA topological change;chromosome organization	10.01.03;10.01.09.05;42.10.03	DNA synthesis and replication;DNA conformation modification (e.g. chromatin);organization of chromosome structure	15664198	Asf1 provides the cells with a buffering system for histone excess generated in response to stalled replication and explains how mammalian cells maintain a critical "active" histone pool available for deposition during recovery from replication stresses.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein HIRA;Histone H3.1;Chromatin assembly factor 1 subunit A;Chromatin assembly factor 1 subunit B;Histone chaperone ASF1B;Histone chaperone ASF1A	HIRA;H3C1;CHAF1A;CHAF1B;ASF1B;ASF1A	DGCR1 HIR TUPLE1;H3FA,HIST1H3A;CAF CAF1P150;CAF1A CAF1P60 MPHOSPH7 MPP7;None;None
2236	ASF1-histone containing complex	Human	None	None	O96017;P49321;P50502;P68431;Q13112;Q9NVP2;Q9Y294	11200;4678;6767;None;8208;55723;25842	MI:0071-molecular sieving	GO:0006260;GO:0006265;GO:0051276	DNA replication;DNA topological change;chromosome organization	10.01.03;10.01.09.05;42.10.03	DNA synthesis and replication;DNA conformation modification (e.g. chromatin);organization of chromosome structure	15664198	Asf1 provides the cells with a buffering system for histone excess generated in response to stalled replication and explains how mammalian cells maintain a critical "active" histone pool available for deposition during recovery from replication stresses.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein kinase Chk2;Nuclear autoantigenic sperm protein;Hsc70-interacting protein;Histone H3.1;Chromatin assembly factor 1 subunit B;Histone chaperone ASF1B;Histone chaperone ASF1A	CHEK2;NASP;ST13;H3C1;CHAF1B;ASF1B;ASF1A	CDS1 CHK2 RAD53;None;AAG2 FAM10A1 HIP SNC6;H3FA,HIST1H3A;CAF1A CAF1P60 MPHOSPH7 MPP7;None;None
2237	SP1-MCAF2 complex	Human	None	None	P08047;Q5U623	6667;80063	MI:0019-coimmunoprecipitation	GO:0006265;GO:0006349;GO:0045892;GO:0032774;GO:0051276;GO:0005634	DNA topological change;regulation of gene expression by genomic imprinting;negative regulation of DNA-templated transcription;RNA biosynthetic process;chromosome organization;nucleus	10.01.09.05;10.01.09.07;11.02.03.04.03;11.02;42.10.03;70.10	DNA conformation modification (e.g. chromatin);DNA imprinting and other epigenetic effects;transcription repression;RNA synthesis;organization of chromosome structure;nucleus	15691849	MCAF2 also binds to SETDB1, but more efficiently to SP1.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Transcription factor Sp1;Activating transcription factor 7-interacting protein 2	SP1;ATF7IP2	TSFP1;MCAF2
2238	MBD1-MCAF1-SETDB1 complex	Human	None	None	Q15047;Q6VMQ6;Q9UIS9	9869;55729;4152	MI:0019-coimmunoprecipitation	GO:0006265;GO:0006349;GO:0045892;GO:0032774;GO:0006479;GO:0051276;GO:0005634	DNA topological change;regulation of gene expression by genomic imprinting;negative regulation of DNA-templated transcription;RNA biosynthetic process;protein methylation;chromosome organization;nucleus	10.01.09.05;10.01.09.07;11.02.03.04.03;11.02;14.07.09;42.10.03;70.10	DNA conformation modification (e.g. chromatin);DNA imprinting and other epigenetic effects;transcription repression;RNA synthesis;posttranslational modification of amino acids (e.g. hydroxylation, methylation);organization of chromosome structure;nucleus	15691849	MCAF1 enhances transcriptional repression by MBD1 together with SETDB1.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone-lysine N-methyltransferase SETDB1;Activating transcription factor 7-interacting protein 1;Methyl-CpG-binding domain protein 1	SETDB1;ATF7IP;MBD1	ESET KIAA0067 KMT1E;MCAF MCAF1;CXXC3 PCM1
2241	HTT-OPTN-RAB8A complex	Human	HD-OPTN-RAB8A complex	HT1080 cells; HeLa cells	P42858;P61006;Q96CV9	3064;4218;10133	MI:0004-affinity chromatography technology;MI:0018-two hybrid	GO:0016192;GO:0000902	vesicle-mediated transport;cell morphogenesis	20.09.07;40.01	vesicular transport (Golgi network, etc.);cell growth / morphogenesis	11137014	Huntingtin has been shown to localise to the plasma membrane, the trans-Golgi network and to vesicles in the cytoplasm. It interacts with HIP1, a protein that links membrane vesicles to the actin cytoskeleton. Coexpressed FIP-2 and Huntingtin enhanced the recruitment of Huntingtin to Rab8-positive vesicular structures, and FIP-2 promoted cell polarisation in a similar way to Rab8. This complex probably involved in membrane trafficking and cellular morphogenesis.	Huntington's disease is characterised by the death of cortical and striatal neurons, and is the result of an expanded polyglutamine tract in the Huntingtin protein.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Huntingtin;Ras-related protein Rab-8A;Optineurin	HTT;RAB8A;OPTN	HD IT15;MEL RAB8;FIP2 GLC1E HIP7 HYPL NRP
2242	TGM2-HD-CALM1 complex	Human	None	None	P0DP23;P21980;P42858	801;7052;3064	MI:0019-coimmunoprecipitation	GO:0065003	protein-containing complex assembly	None	None	14985437	Inhibiting the interaction of calmodulin with transglutaminase and huntingtin protein could decrease cross-linking and diminish huntingtin aggregate formation in the HD brain.	None	P62158 is obsolete. On May 10, 2017 this ID became obsolete. It can now be found as secondary accession in P0DP23, P0DP24 and P0DP25.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Calmodulin-1;Protein-glutamine gamma-glutamyltransferase 2;Huntingtin	CALM1;TGM2;HTT	CALM CAM CAM1;None;HD IT15
2243	TGM2-HD complex	Human	None	None	P21980;P42858	7052;3064	MI:0019-coimmunoprecipitation	GO:0065003	protein-containing complex assembly	None	None	11442349	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Protein-glutamine gamma-glutamyltransferase 2;Huntingtin	TGM2;HTT	None;HD IT15
2254	CTGF/Hcs24-actin(beta/gamma) complex	Human	None	HCS-2/8 cells	P29279;P60709;P63261	1490;60;71	MI:0004-affinity chromatography technology;MI:0019-coimmunoprecipitation	GO:0030037;GO:0030036;GO:0051216;GO:0005737	actin filament reorganization involved in cell cycle;actin cytoskeleton organization;cartilage development;cytoplasm	10.03.05.03;42.04.03;45.03.05.05;70.03	cell cycle dependent actin filament reorganization;actin cytoskeleton;cartilage;cytoplasm	12470643	The authors suggest that binding of CTGF/Hcs24 to actin in chondrocytes may play some important roles in the regulation of cytoskeletal organization and of the cell cycle.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	CCN family member 2;Actin, cytoplasmic 1;Actin, cytoplasmic 2	CCN2;ACTB;ACTG1	CTGF HCS24 IGFBP8;None;ACTG
2255	Cofilin-actin-CAP1 complex	Human	None	None	P23528;P60709;Q01518	1072;60;10487	MI:0096-pull down	GO:0030036;GO:0015629;GO:0048870	actin cytoskeleton organization;actin cytoskeleton;cell motility	42.04.03;70.04.03	actin cytoskeleton;actin cytoskeleton	11950878	As well as full-length CAP1, both CAP1-NT and CAP1-CT enhanced cofilin-induced acceleration of F-actin turnover, whereas their effect was only marginally visible in the absence of cofilin. Localization experiments in fibroblasts demonstrated that CAP1-NT is primarily responsible for accumulating CAP1 with cofilin and actin in dynamic peripheral regions of spreading cells.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cofilin-1;Actin, cytoplasmic 1;Adenylyl cyclase-associated protein 1	CFL1;ACTB;CAP1	CFL;None;CAP
2256	RIAM-Rap1-GTP complex	Human	None	None	P62834;Q7Z5R6	5906;54518	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0007155;GO:0030036;GO:0005886	cell adhesion;actin cytoskeleton organization;plasma membrane	34.07;42.04.03;70.02	cell adhesion;actin cytoskeleton;eukaryotic plasma membrane / membrane attached	15469846	RIAM preferentially interacted with Rap1-GTP compared to Ras-GTP. The results indicate that RIAM is required for localization of Rap1-GTP at the plasma membrane.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Ras-related protein Rap-1A;Amyloid beta A4 precursor protein-binding family B member 1-interacting protein	RAP1A;APBB1IP	KREV1;PREL1 RARP1 RIAM
2258	VILIP-1-AChR-alpha-4-AChR-beta-2 complex	Human	None	None	P17787;P43681;P62760	1141;1137;7447	MI:0096-pull down	GO:0005509;GO:0007268;GO:0051592;GO:1903048	calcium ion binding;chemical synaptic transmission;response to calcium ion;regulation of acetylcholine-gated cation channel activity	16.17.01;34.03.01	calcium binding;synaptic transmission	12202488	The results suggest a rule for VILIP-1 as an AChR-associated protein that modulates the surface expression levels and functional properties of alpha 4beta 2 AChRs in response to changes in the intracellular levels of calcium.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Neuronal acetylcholine receptor subunit beta-2;Neuronal acetylcholine receptor subunit alpha-4;Visinin-like protein 1	CHRNB2;CHRNA4;VSNL1	None;NACRA4;VISL1
2266	PPP3CA-PPP3CB-RCAN1 complex	Human	None	None	P16298;P53805;Q08209	5532;1827;5530	MI:0019-coimmunoprecipitation	GO:0019722	calcium-mediated signaling	30.01.09.03	Ca2+ mediated signal transduction	12809556	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform;Calcipressin-1;Protein phosphatase 3 catalytic subunit alpha	PPP3CB;RCAN1;PPP3CA	CALNA2 CALNB CNA2;ADAPT78 CSP1 DSC1 DSCR1;CALNA CNA
2272	PICK1-GRIP1-GLUR2 complex	Human	None	None	P42262;Q9NRD5;Q9Y3R0	2891;9463;23426	MI:0096-pull down	GO:0006886;GO:0006605;GO:0015031;GO:0006897;GO:0005886	intracellular protein transport;protein targeting;protein transport;endocytosis;plasma membrane	14.04;20.01.10;20.09.18.09.01;70.02	protein targeting, sorting and translocation;protein transport;endocytosis;eukaryotic plasma membrane / membrane attached	16055064	Complex analysed both in vitro and in vivo. This triple complex may function in the presentation of PKC-PICK1 complexes to the ABP/GRIP-GluR2 complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Glutamate receptor 2;PRKCA-binding protein;Glutamate receptor-interacting protein 1	GRIA2;PICK1;GRIP1	GLUR2;PRKCABP;None
2294	ABI1-WASF2 complex	Human	None	None	Q8IZP0;Q9Y6W5	10006;10163	MI:0019-coimmunoprecipitation	GO:0030036	actin cytoskeleton organization	42.04.03	actin cytoskeleton	16155590	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Abl interactor 1;Actin-binding protein WASF2	ABI1;WASF2	SSH3BP1;WAVE2
2297	ABI1-WASL complex	Human	None	None	O00401;Q8IZP0	8976;10006	MI:0004-affinity chromatography technology	GO:0030036	actin cytoskeleton organization	42.04.03	actin cytoskeleton	16155590	None	Neural Wiskott-Aldrich syndrome	None	Homo sapiens (Human);Homo sapiens (Human)	Actin nucleation-promoting factor WASL;Abl interactor 1	WASL;ABI1	None;SSH3BP1
2307	AP3D1-AP3S2 complex	Human	None	None	O14617;P59780	8943;10239	MI:0004-affinity chromatography technology	GO:0006886;GO:0006605;GO:0015031	intracellular protein transport;protein targeting;protein transport	14.04;20.01.10	protein targeting, sorting and translocation;protein transport	15469849	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	AP-3 complex subunit delta-1;AP-3 complex subunit sigma-2	AP3D1;AP3S2	None;None
2308	AP3D1-AP3S1 complex	Human	None	None	O14617;Q92572	8943;1176	MI:0004-affinity chromatography technology;MI:0018-two hybrid	GO:0006886;GO:0006605;GO:0015031	intracellular protein transport;protein targeting;protein transport	14.04;20.01.10	protein targeting, sorting and translocation;protein transport	15469849	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	AP-3 complex subunit delta-1;AP-3 complex subunit sigma-1	AP3D1;AP3S1	None;CLAPS3
2318	ITGA6-ITGB4-Laminin10/12 complex	Human	integrin complex	None	O15230;P07942;P11047;P16144;P23229	3911;3912;3915;3691;3655	MI:0004-affinity chromatography technology	GO:0007155	cell adhesion	34.07	cell adhesion	10671376	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Laminin subunit alpha-5;Laminin subunit beta-1;Laminin subunit gamma-1;Integrin beta-4;Integrin alpha-6	LAMA5;LAMB1;LAMC1;ITGB4;ITGA6	KIAA0533 KIAA1907;None;LAMB2;None;None
2319	ITGA6-ITGB4-Laminin10/12 complex	Human	integrin complex	None	O15230;P11047;P16144;P23229;P55268	3911;3915;3691;3655;3913	MI:0004-affinity chromatography technology	GO:0007155	cell adhesion	34.07	cell adhesion	10671376	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Laminin subunit alpha-5;Laminin subunit gamma-1;Integrin beta-4;Integrin alpha-6;Laminin subunit beta-2	LAMA5;LAMC1;ITGB4;ITGA6;LAMB2	KIAA0533 KIAA1907;LAMB2;None;None;LAMS
2320	ITGA6-ITGB4-CD151 complex	Human	integrin complex	skin	P16144;P23229;P48509	3691;3655;977	MI:0019-coimmunoprecipitation	GO:0005515;GO:0007160	protein binding;cell-matrix adhesion	16.01;34.07.02	protein binding;cell-matrix adhesion	10811835	The recruitment of Cd151 into hemidesmosomes is regulated by the integrin alpha6beta4.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-4;Integrin alpha-6;CD151 antigen	ITGB4;ITGA6;CD151	None;None;TSPAN24
2321	ITGA6-ITGB4-FYN complex	Human	integrin complex	skin	P06241;P16144;P23229	2534;3691;3655	MI:0019-coimmunoprecipitation	GO:0005515;GO:0006921	protein binding;cellular component disassembly involved in execution phase of apoptosis	16.01;40.10.02.02.03	protein binding;disassembly of cell structures	11684709	EGF-R with  ITGA6-ITGB4 and, through the tyrosine kinase Fyn, induces phosphorylation of the beta4 tail (ITGB4) and disruption of hemidesmosomes.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Tyrosine-protein kinase Fyn;Integrin beta-4;Integrin alpha-6	FYN;ITGB4;ITGA6	None;None;None
2322	ITGA6-ITGB4-LAMA5 complex	Human	integrin complex	epithelium, skin	O15230;P16144;P23229	3911;3691;3655	MI:0019-coimmunoprecipitation	GO:0007155	cell adhesion	34.07	cell adhesion	7556090	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Laminin subunit alpha-5;Integrin beta-4;Integrin alpha-6	LAMA5;ITGB4;ITGA6	KIAA0533 KIAA1907;None;None
2323	ITGA6-ITGB4 complex	Human	alpha6-beta4 integrin complex	skin	P16144;P23229	3691;3655	MI:0019-coimmunoprecipitation;MI:0030-cross-linking study	GO:0007155;GO:0048870	cell adhesion;cell motility	34.07	cell adhesion	2649503	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-4;Integrin alpha-6	ITGB4;ITGA6	None;None
2342	ITGAV-ITGB8-MMP14-TGFB1 complex	Human	None	epithelium, nervous tissue	P01137;P06756;P26012;P50281	7040;3685;3696;4323	MI:0004-affinity chromatography technology;MI:0019-coimmunoprecipitation	GO:0016049;GO:1901392	cell growth;regulation of transforming growth factor beta1 activation	40.01	cell growth / morphogenesis	11970960	SLC binds to alphav-beta8, an integrin expressed by normal epithelial and neuronal cells in vivo. This binding results in the membrane type 1 (MT1)-MMP-dependent release of active TGF-beta, which leads to autocrine and paracrine effects on cell growth and matrix production.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transforming growth factor beta-1 proprotein;Integrin alpha-V;Integrin beta-8;Matrix metalloproteinase-14	TGFB1;ITGAV;ITGB8;MMP14	TGFB;MSK8 VNRA VTNR;None;None
2343	ITGAV-ITGB5-PLAUR complex	Human	integrin complex	None	P06756;P18084;Q03405	3685;3693;5329	MI:0019-coimmunoprecipitation	GO:0016477	cell migration	34.05.01	cell migration	10537314	uPAR association with alpha(v)beta5 leads to a functional interaction of these receptors and suggests that uPAR directs cytoskeletal rearrangements and cell migration by altering alpha(v)beta5 signaling specificity.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin alpha-V;Integrin beta-5;Urokinase plasminogen activator surface receptor	ITGAV;ITGB5;PLAUR	MSK8 VNRA VTNR;None;MO3 UPAR
2345	ITGAV-ITGB5-ICAM4 complex	Human	integrin complex	None	P06756;P18084;Q14773	3685;3693;3386	MI:0401-biochemical	GO:0005515;GO:0007155	protein binding;cell adhesion	16.01;34.07	protein binding;cell adhesion	11435317	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin alpha-V;Integrin beta-5;Intercellular adhesion molecule 4	ITGAV;ITGB5;ICAM4	MSK8 VNRA VTNR;None;LW
2346	ITGAV-ITGB5-ADAM9 complex	Human	integrin complex	None	P06756;P18084;Q13443	3685;3693;8754	MI:0054-fluorescence-activated cell sorting	GO:0005515;GO:0007155	protein binding;cell adhesion	16.01;34.07	protein binding;cell adhesion	11162558	MDC-9 interacts with alpha(v)beta(5) in an RGD-independent manner.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin alpha-V;Integrin beta-5;Disintegrin and metalloproteinase domain-containing protein 9	ITGAV;ITGB5;ADAM9	MSK8 VNRA VTNR;None;KIAA0021 MCMP MDC9 MLTNG
2347	ITGAV-ITGB5-SPP1 complex	Human	integrin complex	None	P06756;P10451;P18084	3685;6696;3693	MI:0110-text mining	GO:0005515;GO:0007155	protein binding;cell adhesion	16.01;34.07	protein binding;cell adhesion	16005200	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin alpha-V;Osteopontin;Integrin beta-5	ITGAV;SPP1;ITGB5	MSK8 VNRA VTNR;BNSP OPN;None
2348	ITGAV-ITGB5-CYR61 complex	Human	integrin complex	None	O00622;P06756;P18084	3491;3685;3693	MI:0004-affinity chromatography technology	GO:0016477;GO:0007155;GO:0010761	cell migration;cell adhesion;fibroblast migration	34.05.01;34.07	cell migration;cell adhesion	11287419	CYR61-dependent chemotaxis is mediated through integrin alpha(v)beta5.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	CCN family member 1;Integrin alpha-V;Integrin beta-5	CCN1;ITGAV;ITGB5	CYR61 GIG1 IGFBP10;MSK8 VNRA VTNR;None
2350	ITGAV-ITGB5 complex	Human	alphaV-beta5 integrin complex	placenta cells	P06756;P18084	3685;3693	MI:0004-affinity chromatography technology	GO:0005515;GO:0007155;GO:0008305	protein binding;cell adhesion;integrin complex	16.01;34.07	protein binding;cell adhesion	1694173	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Integrin alpha-V;Integrin beta-5	ITGAV;ITGB5	MSK8 VNRA VTNR;None
2351	ITGB6-FYN-FN1 complex	Human	None	None	P02751;P06241;P18564	2335;2534;3694	MI:0019-coimmunoprecipitation	GO:0035556;GO:0007229	intracellular signal transduction;integrin-mediated signaling pathway	30.01;30.05.02.26	cellular signalling;integrin receptor signalling pathway	12917446	Integrin beta6 signaling activates Fyn and thus promotes oral cancer progression.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Fibronectin;Tyrosine-protein kinase Fyn;Integrin beta-6	FN1;FYN;ITGB6	FN;None;None
2352	ITGAV-ITGB6-SPP1 complex	Human	integrin complex	None	P06756;P10451;P18564	3685;6696;3694	MI:0004-affinity chromatography technology	GO:0005515;GO:0007155	protein binding;cell adhesion	16.01;34.07	protein binding;cell adhesion	16005200	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin alpha-V;Osteopontin;Integrin beta-6	ITGAV;SPP1;ITGB6	MSK8 VNRA VTNR;BNSP OPN;None
2353	ITGAV-ITGB6-TGFB3 complex	Human	integrin complex	None	P06756;P10600;P18564	3685;7043;3694	MI:0004-affinity chromatography technology	GO:0036366	transforming growth factor beta3 activation	None	None	11821050	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin alpha-V;Transforming growth factor beta-3 proprotein;Integrin beta-6	ITGAV;TGFB3;ITGB6	MSK8 VNRA VTNR;None;None
2354	ITGAV-ITGB6 complex	Human	alphaV-beta6 integrin complex	SW480 cells	P06756;P18564	3685;3694	MI:0019-coimmunoprecipitation	GO:0005515;GO:0008305;GO:0007155	protein binding;integrin complex;cell adhesion	16.01;34.07	protein binding;cell adhesion	8798654	Cells expressing alpha(v)beta6 attach, but less avidly, do not spread, and completely fail to proliferate.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Integrin alpha-V;Integrin beta-6	ITGAV;ITGB6	MSK8 VNRA VTNR;None
2355	ITGAV-ITGB3-CD47-FCER2 complex	Human	None	blood cell	P05106;P06734;P06756;Q08722	3690;2208;3685;961	MI:0004-affinity chromatography technology;MI:0019-coimmunoprecipitation	GO:0005515;GO:0006954	protein binding;inflammatory response	16.01;36.25.16.07	protein binding;inflammatory response	10037797	Alpha(v)beta3-CD47 mediates proinflammatory cytokine synthesis via interaction with CD23.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-3;Low affinity immunoglobulin epsilon Fc receptor;Integrin alpha-V;Leukocyte surface antigen CD47	ITGB3;FCER2;ITGAV;CD47	GP3A;CD23A CLEC4J FCE2 IGEBF;MSK8 VNRA VTNR;MER6
2356	ITGB3-ITGAV-CD47 complex	Human	integrin complex	None	P05106;P06756;Q08722	3690;3685;961	MI:0019-coimmunoprecipitation	GO:0005515;GO:0007155;GO:0005886	protein binding;cell adhesion;plasma membrane	16.01;34.07;70.02	protein binding;cell adhesion;eukaryotic plasma membrane / membrane attached	7691831	CD47 interactions with alpha(v)beta3 were found to promote both integrin activation induced by RGD peptide, and alpha(v)beta3 avidity in binding immobilized substrates by enhancing integrin clustering (PMID:14966135).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-3;Integrin alpha-V;Leukocyte surface antigen CD47	ITGB3;ITGAV;CD47	GP3A;MSK8 VNRA VTNR;MER6
2358	ITGAV-ITGB3-SPP1 complex	Human	integrin complex	None	P05106;P06756;P10451	3690;3685;6696	MI:0004-affinity chromatography technology;MI:0019-coimmunoprecipitation;MI:0030-cross-linking study	GO:0016477;GO:0000902;GO:0016049	cell migration;cell morphogenesis;cell growth	34.05.01;40.01	cell migration;cell growth / morphogenesis	9256478	The interaction of OPN with alpha(v)beta3 integrin, expressed on CASMCs (coronary artery smooth muscle cells), causes migration, extracellular matrix invasion, and proliferation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-3;Integrin alpha-V;Osteopontin	ITGB3;ITGAV;SPP1	GP3A;MSK8 VNRA VTNR;BNSP OPN
2359	ITGAV-ITGB3-ADAM15 complex	Human	integrin complex	None	P05106;P06756;Q13444	3690;3685;8751	MI:0004-affinity chromatography technology	GO:0005515;GO:0007155;GO:0005886;GO:0031012	protein binding;cell adhesion;plasma membrane;extracellular matrix	16.01;34.07;70.02;70.27.01	protein binding;cell adhesion;eukaryotic plasma membrane / membrane attached;extracellular matrix component	11882657	ADAM15/alpha(v)beta3 interactions may be important in the adhesion of tumour cells to endothelium (PMID:9914169).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-3;Integrin alpha-V;Disintegrin and metalloproteinase domain-containing protein 15	ITGB3;ITGAV;ADAM15	GP3A;MSK8 VNRA VTNR;MDC15
2362	ITAGV-ITGB3-F11R complex	Human	integrin complex	None	P05106;P06756;Q9Y624	3690;3685;50848	MI:0019-coimmunoprecipitation	GO:0001568;GO:0001944	blood vessel development;vasculature development	47.03.03.02	vessels	12750158	JAM-1/A and alpha(v)beta3 form a complex in the absence of bFGF.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-3;Integrin alpha-V;Junctional adhesion molecule A	ITGB3;ITGAV;F11R	GP3A;MSK8 VNRA VTNR;JAM1 JCAM
2363	ITGAV-ITGB3-PXN-PTK2b complex	Human	integrin complex	None	P05106;P06756;P49023;Q14289	3690;3685;5829;2185	MI:0004-affinity chromatography technology;MI:0019-coimmunoprecipitation	GO:0005515;GO:0007155	protein binding;cell adhesion	16.01;34.07	protein binding;cell adhesion	11683411	This complex could play key role in the regulation of cell adhesion-triggered cytoskeletal organization and signal transduction in podosome-containing cells derived from monocytic lineage.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-3;Integrin alpha-V;Paxillin;Protein-tyrosine kinase 2-beta	ITGB3;ITGAV;PXN;PTK2B	GP3A;MSK8 VNRA VTNR;None;FAK2 PYK2 RAFTK
2364	ITGAV-ITGB3-ADAM23 complex	Human	integrin complex	None	O75077;P05106;P06756	8745;3690;3685	MI:0004-affinity chromatography technology	GO:0005515;GO:0007155	protein binding;cell adhesion	16.01;34.07	protein binding;cell adhesion	10749942	ADAM 23, through its disintegrin-like domain, may function as an adhesion molecule involved in alpha(v)beta3-mediated cell interactions occurring in normal and pathological processes, including progression of malignant tumors from neural origin.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Disintegrin and metalloproteinase domain-containing protein 23;Integrin beta-3;Integrin alpha-V	ADAM23;ITGB3;ITGAV	MDC3;GP3A;MSK8 VNRA VTNR
2365	ITGAV-ITGB3-COL4A3 complex	Human	integrin complex	None	P05106;P06756;Q01955	3690;3685;1285	MI:0004-affinity chromatography technology	GO:0006417	regulation of translation	12.07	translational control	12682293	Tumstatin binding to alpha(v)beta3 integrin leads to the inhibition of Cap-dependent translation (protein synthesis) mediated by focal adhesion kinase/phosphatidylinositol 3-kinase/Akt/mTOR/4E-BP1 pathway.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-3;Integrin alpha-V;Collagen alpha-3(IV) chain	ITGB3;ITGAV;COL4A3	GP3A;MSK8 VNRA VTNR;None
2366	ITGAV-ITGB3-PPAP2b complex	Human	integrin complex	None	O14495;P05106;P06756	8613;3690;3685	MI:0004-affinity chromatography technology	GO:0007155;GO:0001568;GO:0001944;GO:0005886	cell adhesion;blood vessel development;vasculature development;plasma membrane	34.07;47.03.03.02;70.02	cell adhesion;vessels;eukaryotic plasma membrane / membrane attached	16099422	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Phospholipid phosphatase 3;Integrin beta-3;Integrin alpha-V	PLPP3;ITGB3;ITGAV	LPP3 PPAP2B;GP3A;MSK8 VNRA VTNR
2369	ITGAV-ITGB3-EGFR complex	Human	integrin complex	None	P00533;P05106;P06756	1956;3690;3685	MI:0019-coimmunoprecipitation	GO:0005515;GO:0007173;GO:0007229	protein binding;epidermal growth factor receptor signaling pathway;integrin-mediated signaling pathway	16.01;30.05.01.12.01;30.05.02.26	protein binding;EGF-receptor signalling pathway;integrin receptor signalling pathway	15834425	The coordination between EGFR and alpha(v)beta3 is essential for the early events of HCMV infection, including viral entry.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Epidermal growth factor receptor;Integrin beta-3;Integrin alpha-V	EGFR;ITGB3;ITGAV	ERBB ERBB1 HER1;GP3A;MSK8 VNRA VTNR
2370	ITGA2B-ITGB3-CD9 complex	Human	integrin complex	blood cell	P05106;P08514;P21926	3690;3674;928	MI:0019-coimmunoprecipitation	GO:0007155;GO:0005886	cell adhesion;plasma membrane	34.07;70.02	cell adhesion;eukaryotic plasma membrane / membrane attached	10429193	CD9 is part of a protein complex that co-precipitates with aIIb3 under native conditions and provides evidence of CD9 and aIIbb3 associating in resting, inactive platelets (PMID:9355765).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-3;Integrin alpha-IIb;CD9 antigen	ITGB3;ITGA2B;CD9	GP3A;GP2B ITGAB;MIC3, TSPAN29
2374	ITGAV-ITGB3-LAMA4 complex	Human	integrin complex	None	P05106;P06756;Q16363	3690;3685;3910	MI:0004-affinity chromatography technology	GO:0005515;GO:0007155;GO:0031012	protein binding;cell adhesion;extracellular matrix	16.01;34.07;70.27.01	protein binding;cell adhesion;extracellular matrix component	16824487	The alpha4 laminin subunit mediates endothelial cell-adhesion through alpha(v)beta3 integrin and that the key site is G1121-1139.	The G1121-1139 peptide promotes angiogenesis in vivo.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-3;Integrin alpha-V;Laminin subunit alpha-4	ITGB3;ITGAV;LAMA4	GP3A;MSK8 VNRA VTNR;None
2375	FN1-TGM2 complex	Human	None	None	P02751;P21980	2335;7052	MI:0030-cross-linking study	GO:0005515;GO:0007155	protein binding;cell adhesion	16.01;34.07	protein binding;cell adhesion	10684262	Overexpression of tTG increases the amount of Fn on the cell surface, enhances adhesion and spreading of fibronectin.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Fibronectin;Protein-glutamine gamma-glutamyltransferase 2	FN1;TGM2	FN;None
2376	ITGA2B-ITGB3-FN1-TGM2 complex	Human	None	None	P02751;P05106;P08514;P21980	2335;3690;3674;7052	MI:0019-coimmunoprecipitation	GO:0005515;GO:0007155;GO:0005886	protein binding;cell adhesion;plasma membrane	16.01;34.07;70.02	protein binding;cell adhesion;eukaryotic plasma membrane / membrane attached	10684262	The tissue transglutaminase mediates the interaction of integrins with fibronectin, thereby acting as an integrin-associated coreceptor to promote cell adhesion and spreading.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Fibronectin;Integrin beta-3;Integrin alpha-IIb;Protein-glutamine gamma-glutamyltransferase 2	FN1;ITGB3;ITGA2B;TGM2	FN;GP3A;GP2B ITGAB;None
2377	ITGA2b-ITGB3-CD47-SRC complex	Human	integrin complex	None	P05106;P08514;P12931;Q08722	3690;3674;6714;961	MI:0004-affinity chromatography technology;MI:0019-coimmunoprecipitation	GO:0005515;GO:0005886	protein binding;plasma membrane	16.01;70.02	protein binding;eukaryotic plasma membrane / membrane attached	9169439	At least five members of the Src-type kinase family are expressed in megakaryocytes and platelets (PMID:7545532) but only c-Src could be detected in the alpha IIb-beta 3-IAP complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-3;Integrin alpha-IIb;Proto-oncogene tyrosine-protein kinase Src;Leukocyte surface antigen CD47	ITGB3;ITGA2B;SRC;CD47	GP3A;GP2B ITGAB;SRC1;MER6
2378	ITGA2b-ITGB3-TLN1 complex	Human	integrin complex	blood cell	P05106;P08514;Q9Y490	3690;3674;7094	MI:0004-affinity chromatography technology	GO:0005515	protein binding	16.01	protein binding	8663236	The purified talin binds to the cytoplasmic sequences of both alpha  and beta  subunits of this integrin. The regulated binding of talin to integrin beta tails is a final common element of cellular signaling cascades that control integrin activation (PMID:14526080).	Disrupting the beta3 integrin-talin interaction blocks {alpha}IIb-beta3 activation and has a dramatic antithrombotic effect (PMID:17627302).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-3;Integrin alpha-IIb;Talin-1	ITGB3;ITGA2B;TLN1	GP3A;GP2B ITGAB;KIAA1027 TLN
2379	ITGA2B-ITGB3-CIB1 complex	Human	integrin complex	liver	P05106;P08514;Q99828	3690;3674;10519	MI:0018-two hybrid;MI:0411-enzyme linked immunosorbent assay	GO:0005509;GO:0007155	calcium ion binding;cell adhesion	16.17.01;34.07	calcium binding;cell adhesion	9030514	CIB does not regulate alpha-IIb-beta3 inside-out signaling, but rather is involved in an alpha-IIb-beta3 post-receptor occupancy event.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-3;Integrin alpha-IIb;Calcium and integrin-binding protein 1	ITGB3;ITGA2B;CIB1	GP3A;GP2B ITGAB;CIB KIP PRKDCIP
2381	ITGA2B-ITGB3 complex	Human	beta2B-beta3 integrin complex	in vitro	P05106;P08514	3690;3674	MI:0004-affinity chromatography technology	GO:0008305;GO:0007155	integrin complex;cell adhesion	34.07	cell adhesion	8132607	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-3;Integrin alpha-IIb	ITGB3;ITGA2B	GP3A;GP2B ITGAB
2382	ITGA2B-ITGB3-F11R complex	Human	integrin complex	None	P05106;P08514;Q9Y624	3690;3674;50848	MI:0004-affinity chromatography technology	GO:0007155	cell adhesion	34.07	cell adhesion	11171323	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-3;Integrin alpha-IIb;Junctional adhesion molecule A	ITGB3;ITGA2B;F11R	GP3A;GP2B ITGAB;JAM1 JCAM
2383	ITGA5-ITGB1-FN1-TGM2 complex	Human	None	None	P02751;P05556;P08648;P21980	2335;3688;3678;7052	MI:0019-coimmunoprecipitation	GO:0005515;GO:0007155;GO:0005886	protein binding;cell adhesion;plasma membrane	16.01;34.07;70.02	protein binding;cell adhesion;eukaryotic plasma membrane / membrane attached	10684262	The tissue transglutaminase mediates the interaction of integrins with fibronectin, thereby acting as an integrin-associated coreceptor to promote cell adhesion and spreading.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Fibronectin;Integrin beta-1;Integrin alpha-5;Protein-glutamine gamma-glutamyltransferase 2	FN1;ITGB1;ITGA5;TGM2	FN;FNRB, MDF2, MSK12;FNRA;None
2384	ITGA5-ITGB1-ADAM15 complex	Human	integrin complex	None	P05556;P08648;Q13444	3688;3678;8751	MI:0004-affinity chromatography technology	GO:0005515;GO:0007155	protein binding;cell adhesion	16.01;34.07	protein binding;cell adhesion	9914169	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-1;Integrin alpha-5;Disintegrin and metalloproteinase domain-containing protein 15	ITGB1;ITGA5;ADAM15	FNRB, MDF2, MSK12;FNRA;MDC15
2385	ITGA5-ITGB4 complex	Human	alpha5-beta4 integrin complex	fibroblasts GM334 cells	P05556;P08648	3688;3678	MI:0019-coimmunoprecipitation	GO:0007155;GO:0008305	cell adhesion;integrin complex	34.07	cell adhesion	3546305	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-1;Integrin alpha-5	ITGB1;ITGA5	FNRB, MDF2, MSK12;FNRA
2390	CD98-ITGB1-LAT2 complex	Human	None	epithelium	P05556;P08195;Q9UHI5	3688;6520;23428	MI:0019-coimmunoprecipitation	GO:0098609	cell-cell adhesion	None	None	11507094	The specific molecular ratio between the heterodimer CD98/LAT-2 and beta 1 integrin may be required for the polarity of epithelial cells.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-1;4F2 cell-surface antigen heavy chain;Large neutral amino acids transporter small subunit 2	ITGB1;SLC3A2;SLC7A8	FNRB, MDF2, MSK12;MDU1;LAT2
2395	ITGA7-ITGB1-CD151 complex	Human	integrin complex	muscle	P05556;P48509;Q13683	3688;977;3679	MI:0019-coimmunoprecipitation	GO:0005515;GO:0007155	protein binding;cell adhesion	16.01;34.07	protein binding;cell adhesion	11884516	The expression of alpha7-beta1 in K562 cells results in increased levels of CD151 at its surface.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-1;CD151 antigen;Integrin alpha-7	ITGB1;CD151;ITGA7	FNRB, MDF2, MSK12;TSPAN24;None
2396	ITGA7-ITGB1-CD9 complex	Human	integrin complex	None	P05556;P21926;Q13683	3688;928;3679	MI:0019-coimmunoprecipitation	GO:0007519	skeletal muscle tissue development	41.05.15	myogenesis	10459022	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-1;CD9 antigen;Integrin alpha-7	ITGB1;CD9;ITGA7	FNRB, MDF2, MSK12;MIC3, TSPAN29;None
2397	ITGA7-ITGB1-ITGB1BP3 complex	Human	None	C2C12 myoblasts	P05556;Q13683;Q9NPI5	3688;3679;27231	MI:0019-coimmunoprecipitation	GO:0007155	cell adhesion	34.07	cell adhesion	12941630	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-1;Integrin alpha-7;Nicotinamide riboside kinase 2	ITGB1;ITGA7;NMRK2	FNRB, MDF2, MSK12;None;ITGB1BP3 NRK2
2398	ITGA3-ITGB1-BSG complex	Human	integrin complex	None	P05556;P26006;P35613	3688;3675;682	MI:0019-coimmunoprecipitation	GO:0007160;GO:1904464	cell-matrix adhesion;regulation of matrix metallopeptidase secretion	34.07.02	cell-matrix adhesion	9360995	The physical association between EMMPRIN (Basigin) and alpha3-beta1 may play a role in adhesion-induced matrix metalloproteinase production.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-1;Integrin alpha-3;Basigin	ITGB1;ITGA3;BSG	FNRB, MDF2, MSK12;MSK18;None
2399	ITGA3-ITGB1-CD63 complex	Human	integrin complex	None	P05556;P08962;P26006	3688;967;3675	MI:0019-coimmunoprecipitation	GO:0007155;GO:0048870	cell adhesion;cell motility	34.07	cell adhesion	9360995	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-1;CD63 antigen;Integrin alpha-3	ITGB1;CD63;ITGA3	FNRB, MDF2, MSK12;MLA1 TSPAN30;MSK18
2401	ITGA3-ITGB1-THBS1 complex	Human	integrin complex	None	P05556;P07996;P26006	3688;7057;3675	MI:0004-affinity chromatography technology	GO:0007155	cell adhesion	34.07	cell adhesion	11358957	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-1;Thrombospondin-1;Integrin alpha-3	ITGB1;THBS1;ITGA3	FNRB, MDF2, MSK12;TSP TSP1;MSK18
2406	ITGA3-ITGB1 complex	Human	alpha3-beta1 integrin compex	fibroblast GM3349 cells	P05556;P26006	3688;3675	MI:0019-coimmunoprecipitation	GO:0007155;GO:0008305	cell adhesion;integrin complex	34.07	cell adhesion	3546305	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-1;Integrin alpha-3	ITGB1;ITGA3	FNRB, MDF2, MSK12;MSK18
2411	ITGA6-ITGB1-CD151 complex	Human	integrin complex	None	P05556;P23229;P48509	3688;3655;977	MI:0019-coimmunoprecipitation	GO:0016477	cell migration	34.05.01	cell migration	11884516	The YXXphi motif-mediated internalization of CD151 promotes integrin-dependent cell migration by modulating the endocytosis and/or vesicular trafficking of its associated integrins (PMID:17716972).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-1;Integrin alpha-6;CD151 antigen	ITGB1;ITGA6;CD151	FNRB, MDF2, MSK12;None;TSPAN24
2413	ITGA6-ITGB1 complex	Human	alpha6-beta1 Integrin complex	fibroblast FS4 cells	P05556;P23229	3688;3655	MI:0004-affinity chromatography technology	GO:0007155;GO:0008305	cell adhesion;integrin complex	34.07	cell adhesion	2649503	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-1;Integrin alpha-6	ITGB1;ITGA6	FNRB, MDF2, MSK12;None
2416	ITGB1-RAP1A-PKD1 complex	Human	None	None	P05556;P62834;P98161	3688;5906;5310	MI:0019-coimmunoprecipitation	GO:0033623	regulation of integrin activation	None	None	16111639	The authors propose a novel adaptor protein function for PKD1 in regulating integrin functional activity in T cells that involves rapid, transient membrane translocation of both PKD1 and Rap1 to beta-1 integrins.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-1;Ras-related protein Rap-1A;Polycystin-1	ITGB1;RAP1A;PKD1	FNRB, MDF2, MSK12;KREV1;None
2417	ITGA4-ITGB1-EMILIN1 complex	Human	integrin complex	None	P05556;P13612;Q9Y6C2	3688;3676;11117	MI:0004-affinity chromatography technology	GO:0007155;GO:0048870	cell adhesion;cell motility	34.07	cell adhesion	12456677	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-1;Integrin alpha-4;EMILIN-1	ITGB1;ITGA4;EMILIN1	FNRB, MDF2, MSK12;CD49D;EMI
2418	ITGA4-ITGB1 complex	Human	alpha4-beta1 integrin complex	fibroblasts GM334 cells	P05556;P13612	3688;3676	MI:0019-coimmunoprecipitation	GO:0007155;GO:0008305	cell adhesion;integrin complex	34.07	cell adhesion	3546305	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-1;Integrin alpha-4	ITGB1;ITGA4	FNRB, MDF2, MSK12;CD49D
2419	ITGA4-ITGB1-CD81 complex	Human	integrin complex	None	P05556;P13612;P60033	3688;3676;975	MI:0019-coimmunoprecipitation	GO:0007155	cell adhesion	34.07	cell adhesion	10229664	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-1;Integrin alpha-4;CD81 antigen	ITGB1;ITGA4;CD81	FNRB, MDF2, MSK12;CD49D;TAPA1 TSPAN28
2420	ITGA4-ITGB1-CD53 complex	Human	None	None	P05556;P13612;P19397	3688;3676;963	MI:0019-coimmunoprecipitation	GO:0005515	protein binding	16.01	protein binding	8757325	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-1;Integrin alpha-4;Leukocyte surface antigen CD53	ITGB1;ITGA4;CD53	FNRB, MDF2, MSK12;CD49D;MOX44 TSPAN25
2421	ITGA4-ITGB1-VCAM1 complex	Human	integrin complex	None	P05556;P13612;P19320	3688;3676;7412	MI:0004-affinity chromatography technology	GO:0007155	cell adhesion	34.07	cell adhesion	10623819	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-1;Integrin alpha-4;Vascular cell adhesion protein 1	ITGB1;ITGA4;VCAM1	FNRB, MDF2, MSK12;CD49D;None
2422	ITGA4-ITGB1-JAM2 complex	Human	integrin complex	None	P05556;P13612;P57087	3688;3676;58494	MI:0004-affinity chromatography technology	GO:0007155	cell adhesion	34.07	cell adhesion	12070135	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-1;Integrin alpha-4;Junctional adhesion molecule B	ITGB1;ITGA4;JAM2	FNRB, MDF2, MSK12;CD49D;C21orf43 VEJAM
2423	ITGA4-ITGB1-CD47 complex	Human	integrin complex	None	P05556;P13612;Q08722	3688;3676;961	MI:0019-coimmunoprecipitation	GO:0007155	cell adhesion	34.07	cell adhesion	15292185	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-1;Integrin alpha-4;Leukocyte surface antigen CD47	ITGB1;ITGA4;CD47	FNRB, MDF2, MSK12;CD49D;MER6
2424	ITGA4-ITGB1-CD63 complex	Human	integrin complex	None	P05556;P08962;P13612	3688;967;3676	MI:0019-coimmunoprecipitation	GO:0005515	protein binding	16.01	protein binding	8757325	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-1;CD63 antigen;Integrin alpha-4	ITGB1;CD63;ITGA4	FNRB, MDF2, MSK12;MLA1 TSPAN30;CD49D
2426	ITGA4-ITGB1-THBS1 complex	Human	integrin complex	None	P05556;P07996;P13612	3688;7057;3676	MI:0004-affinity chromatography technology	GO:0007155	cell adhesion	34.07	cell adhesion	11980922	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-1;Thrombospondin-1;Integrin alpha-4	ITGB1;THBS1;ITGA4	FNRB, MDF2, MSK12;TSP TSP1;CD49D
2428	ITGA4-ITGB1-THBS2 complex	Human	integrin complex	None	P05556;P13612;P35442	3688;3676;7058	MI:0004-affinity chromatography technology	GO:0007155	cell adhesion	34.07	cell adhesion	11980922	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-1;Integrin alpha-4;Thrombospondin-2	ITGB1;ITGA4;THBS2	FNRB, MDF2, MSK12;CD49D;TSP2
2429	ITGA2-ITGB1-CD47 complex	Human	integrin complex	None	P05556;P17301;Q08722	3688;3673;961	MI:0019-coimmunoprecipitation	GO:0006935	chemotaxis	34.11.03.03	chemotaxis	10397731	Integrin-associated protein (IAP/CD47) augments the function of alpha2-beta1 integrin in smooth muscle cells (SMC), resulting in enhanced chemotaxis toward soluble collagen.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-1;Integrin alpha-2;Leukocyte surface antigen CD47	ITGB1;ITGA2;CD47	FNRB, MDF2, MSK12;CD49B;MER6
2430	ITGA2-ITGB1-CHAD complex	Human	integrin complex	None	O15335;P05556;P17301	1101;3688;3673	MI:0004-affinity chromatography technology;MI:0019-coimmunoprecipitation	GO:0007155	cell adhesion	34.07	cell adhesion	9281592	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Chondroadherin;Integrin beta-1;Integrin alpha-2	CHAD;ITGB1;ITGA2	SLRR4A;FNRB, MDF2, MSK12;CD49B
2431	ITGA2-ITGB1-COL6A3 complex	Human	integrin complex	None	P05556;P12111;P17301	3688;1293;3673	MI:0004-affinity chromatography technology	GO:0005515;GO:0007155;GO:0005886;GO:0031012	protein binding;cell adhesion;plasma membrane;extracellular matrix	16.01;34.07;70.02;70.27.01	protein binding;cell adhesion;eukaryotic plasma membrane / membrane attached;extracellular matrix component	8387021	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-1;Collagen alpha-3(VI) chain;Integrin alpha-2	ITGB1;COL6A3;ITGA2	FNRB, MDF2, MSK12;None;CD49B
2432	ITGA2-ITGB1 complex	Human	alpha2-beta1 integrin complex	fibroblasts GM334 cells	P05556;P17301	3688;3673	MI:0019-coimmunoprecipitation	GO:0007155;GO:0008305	cell adhesion;integrin complex	34.07	cell adhesion	3546305	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-1;Integrin alpha-2	ITGB1;ITGA2	FNRB, MDF2, MSK12;CD49B
2434	ITGA1-ITGB1-COL6A3 complex	Human	integrin complex	None	P05556;P12111;P56199	3688;1293;3672	MI:0004-affinity chromatography technology	GO:0005515;GO:0007155;GO:0005886;GO:0031012	protein binding;cell adhesion;plasma membrane;extracellular matrix	16.01;34.07;70.02;70.27.01	protein binding;cell adhesion;eukaryotic plasma membrane / membrane attached;extracellular matrix component	8387021	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-1;Collagen alpha-3(VI) chain;Integrin alpha-1	ITGB1;COL6A3;ITGA1	FNRB, MDF2, MSK12;None;None
2435	ITGA1-ITGB1-PTPN2 complex	Human	integrin complex	None	P05556;P17706;P56199	3688;5771;3672	MI:0019-coimmunoprecipitation	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	30.05.01.12	transmembrane receptor protein tyrosine kinase signalling pathways	15592458	The cytoplasmic tail of alpha(1) integrin selectively interacts with a ubiquitously expressed TCPTP and activates it after cell adhesion to collagen.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-1;Tyrosine-protein phosphatase non-receptor type 2;Integrin alpha-1	ITGB1;PTPN2;ITGA1	FNRB, MDF2, MSK12;PTPT;None
2436	ITGAV-ITGB1 complex	Human	alphaV-beta1 integrin complex	Neuroblastoma IMR32 cells	P05556;P06756	3688;3685	MI:0004-affinity chromatography technology;MI:0019-coimmunoprecipitation	GO:0005515;GO:0007155;GO:0008305	protein binding;cell adhesion;integrin complex	16.01;34.07	protein binding;cell adhesion	2138612	The cell surface expression level of alphaV-beta1 is dependent on the number of alphaV subunits available after the formation of other alphaV-containing heterodimers (PMID:11997396).	None	None	Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-1;Integrin alpha-V	ITGB1;ITGAV	FNRB, MDF2, MSK12;MSK8 VNRA VTNR
2437	ITGA6-ITGB1-CYR61 complex	Human	integrin complex	None	O00622;P05556;P23229	3491;3688;3655	MI:0004-affinity chromatography technology	GO:0007155;GO:0001568;GO:0001944	cell adhesion;blood vessel development;vasculature development	34.07;47.03.03.02	cell adhesion;vessels	12826661	The T1 sequence in CCN1 is a novel binding motif for integrin alpha6-beta1.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	CCN family member 1;Integrin beta-1;Integrin alpha-6	CCN1;ITGB1;ITGA6	CYR61 GIG1 IGFBP10;FNRB, MDF2, MSK12;None
2439	ITGA8-ITGB1 complex	Human	alpha8-beta1 integrin complex	HISM cells	P05556;P53708	3688;8516	MI:0004-affinity chromatography technology	GO:0005515;GO:0007155;GO:0008305	protein binding;cell adhesion;integrin complex	16.01;34.07	protein binding;cell adhesion	7559467	This integrin is receptor for tenascin, fibronectin, and vitronectin.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-1;Integrin alpha-8	ITGB1;ITGA8	FNRB, MDF2, MSK12;None
2440	ITGA9-ITGB1-ADAM9 complex	Human	integrin complex	None	P05556;Q13443;Q13797	3688;8754;3680	MI:0004-affinity chromatography technology	GO:0005515	protein binding	16.01	protein binding	11882657	Alpha9-eta1-ADAM interactions may have a broad significance in many biological and pathological processes such as fertilization, development, and tissue remodeling.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-1;Disintegrin and metalloproteinase domain-containing protein 9;Integrin alpha-9	ITGB1;ADAM9;ITGA9	FNRB, MDF2, MSK12;KIAA0021 MCMP MDC9 MLTNG;None
2442	ITGA9-ITGB1-VCAM1 complex	Human	integrin complex	None	P05556;P19320;Q13797	3688;7412;3680	MI:0004-affinity chromatography technology	GO:0016477;GO:0007155;GO:0072672	cell migration;cell adhesion;neutrophil extravasation	34.05.01;34.07	cell migration;cell adhesion	10209034	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-1;Vascular cell adhesion protein 1;Integrin alpha-9	ITGB1;VCAM1;ITGA9	FNRB, MDF2, MSK12;None;None
2443	ITGA9-ITGB1-TNC complex	Human	integrin complex	None	P05556;P24821;Q13797	3688;3371;3680	MI:0004-affinity chromatography technology	GO:0005515	protein binding	16.01	protein binding	9565552	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-1;Tenascin;Integrin alpha-9	ITGB1;TNC;ITGA9	FNRB, MDF2, MSK12;HXB;None
2444	ITGA9-ITGB1 complex	Human	alpha9-beta1 integrin complex	SW480 cells	P05556;Q13797	3688;3680	MI:0019-coimmunoprecipitation	GO:0005515;GO:0007155;GO:0016049;GO:0008305	protein binding;cell adhesion;cell growth;integrin complex	16.01;34.07;40.01	protein binding;cell adhesion;cell growth / morphogenesis	8798654	Cells expressing alpha9-beta1 attach and spread equally well, and also proliferate, but significantly less than do cells expressing alpha(v)beta3.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-1;Integrin alpha-9	ITGB1;ITGA9	FNRB, MDF2, MSK12;None
2445	ITGA9-ITGB1-ADAM15 complex	Human	integrin complex	None	P05556;Q13444;Q13797	3688;8751;3680	MI:0004-affinity chromatography technology	GO:0005515;GO:0098609	protein binding;cell-cell adhesion	16.01	protein binding	11882657	Alpha9-beta 1-ADAM interactions may have a broad significance in many biological and pathological processes such as fertilization, development, and tissue remodeling.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-1;Disintegrin and metalloproteinase domain-containing protein 15;Integrin alpha-9	ITGB1;ADAM15;ITGA9	FNRB, MDF2, MSK12;MDC15;None
2446	ITGA9-ITGB1-FIGF complex	Human	integrin complex	None	O43915;P05556;Q13797	2277;3688;3680	MI:0004-affinity chromatography technology	GO:0016477;GO:0007155;GO:0030154	cell migration;cell adhesion;cell differentiation	34.05.01;34.07;40.02	cell migration;cell adhesion;cell differentiation	15590642	Alpha9-beta1 directly binds to VEGF-C and -D and contributes to lymphangiogenesis.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Vascular endothelial growth factor D;Integrin beta-1;Integrin alpha-9	VEGFD;ITGB1;ITGA9	FIGF;FNRB, MDF2, MSK12;None
2447	ITGA9-ITGB1-ADAM12 complex	Human	integrin complex	None	O43184;P05556;Q13797	8038;3688;3680	MI:0004-affinity chromatography technology	GO:0005886;GO:0098609	plasma membrane;cell-cell adhesion	70.02	eukaryotic plasma membrane / membrane attached	10944520	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Disintegrin and metalloproteinase domain-containing protein 12;Integrin beta-1;Integrin alpha-9	ADAM12;ITGB1;ITGA9	MLTN;FNRB, MDF2, MSK12;None
2453	Multiprotein complex (CBLB, EGFR, SH3KBP1)	Human	Multiprotein complex (CBLB, EGFR, CIN85)	HEK293T cells	P00533;Q13191;Q96B97	1956;868;30011	MI:0019-coimmunoprecipitation	GO:0016567;GO:1905146	protein ubiquitination;lysosomal protein catabolic process	14.07.05	modification by ubiquitination, deubiquitination	12218189	The adaptor protein CIN85 and its homologue CMS are monoubiquitinated by Cbl/Cbl-b after epidermal growth factor (EGF) stimulation. CIN85 has a dual role in controlling EGFR down-regulation, because it both promotes receptor internalization and participates in endosomal sorting and subsequent degradation of activated receptors.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Epidermal growth factor receptor;E3 ubiquitin-protein ligase CBL-B;SH3 domain-containing kinase-binding protein 1	EGFR;CBLB;SH3KBP1	ERBB ERBB1 HER1;RNF56;CIN85
2454	CBL-EGFR-SH3GL2-SH3KBP1 complex	Human	None	HeLa cells	P00533;P22681;Q96B97;Q99962	1956;867;30011;6456	MI:0019-coimmunoprecipitation	GO:0006900;GO:0016050;GO:0006897;GO:0007173	vesicle budding from membrane;vesicle organization;endocytosis;epidermal growth factor receptor signaling pathway	20.09.07.25;20.09.18.09.01;30.05.01.12.01	vesicle formation;endocytosis;EGF-receptor signalling pathway	11894095	Cbl rapidly recruits CIN85 and endophilins to form a complex with activated EGF receptors, thus controlling receptor internalization.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Epidermal growth factor receptor;E3 ubiquitin-protein ligase CBL;SH3 domain-containing kinase-binding protein 1;Endophilin-A1	EGFR;CBL;SH3KBP1;SH3GL2	ERBB ERBB1 HER1;CBL2 RNF55;CIN85;CNSA2 SH3D2A
2455	CIN85-SH3GL2 complex	Human	None	HEK 293T cells	Q96B97;Q99962	30011;6456	MI:0096-pull down	GO:0006900;GO:0016050;GO:0006897	vesicle budding from membrane;vesicle organization;endocytosis	20.09.07.25;20.09.18.09.01	vesicle formation;endocytosis	11894095	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	SH3 domain-containing kinase-binding protein 1;Endophilin-A1	SH3KBP1;SH3GL2	CIN85;CNSA2 SH3D2A
2456	MET-CIN85-SH3GL3-CBL complex, HGF stimulated	Human	None	HeLa cells	P08581;P22681;Q96B97;Q99963	4233;867;30011;6457	MI:0006-anti bait coimmunoprecipitation	GO:0006900;GO:0016050;GO:0006897;GO:0007169	vesicle budding from membrane;vesicle organization;endocytosis;transmembrane receptor protein tyrosine kinase signaling pathway	20.09.07.25;20.09.18.09.01;30.05.01.12	vesicle formation;endocytosis;transmembrane receptor protein tyrosine kinase signalling pathways	11894096	The authors propose the following model: upon ligand activation, HGF receptor becomes tyrosine phosphorylated, binds and phosphorylates Cbl, which in turn targets the receptor to clathrin-coated pits by recruiting the CIN85\u2013endophilin complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Hepatocyte growth factor receptor;E3 ubiquitin-protein ligase CBL;SH3 domain-containing kinase-binding protein 1;Endophilin-A3	MET;CBL;SH3KBP1;SH3GL3	None;CBL2 RNF55;CIN85;CNSA3 SH3D2C
2457	CIN85-SH3GL3 complex	Human	None	None	Q96B97;Q99963	30011;6457	MI:0018-two hybrid;MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0006900;GO:0016050;GO:0006897	vesicle budding from membrane;vesicle organization;endocytosis	20.09.07.25;20.09.18.09.01	vesicle formation;endocytosis	11894096	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	SH3 domain-containing kinase-binding protein 1;Endophilin-A3	SH3KBP1;SH3GL3	CIN85;CNSA3 SH3D2C
2462	Caveolin-1 homodimer complex	Human	None	COS7 cells	Q03135	857	MI:0030-cross-linking study	None	None	None	None	15782218	None	None	None	Homo sapiens (Human)	Caveolin-1	CAV1	CAV
2470	p130Cas-ER-alpha-cSrc-kinase- PI3-kinase p85-subunit complex	Human	None	T47D breast cancer cells	P03372;P12931;P27986;P56945	2099;6714;5295;9564	MI:0006-anti bait coimmunoprecipitation	GO:0006468;GO:0071391;GO:0030520;GO:0006355;GO:0070372	protein phosphorylation;cellular response to estrogen stimulus;intracellular estrogen receptor signaling pathway;regulation of DNA-templated transcription;regulation of ERK1 and ERK2 cascade	14.07.03;11.02.03.04	modification by phosphorylation, dephosphorylation, autophosphorylation;transcriptional control	15020686	The authors suggest that estradiol triggers association of ER-alpha, c-Src, the p85 subunit of PI 3-kinase (PI3K) and p130Cas in a macromolecular complex and activates the c-Src kinase leading to p130Cas-dependent Erk1/2 phosphorylation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Estrogen receptor;Proto-oncogene tyrosine-protein kinase Src;Phosphatidylinositol 3-kinase regulatory subunit alpha;Breast cancer anti-estrogen resistance protein 1	ESR1;SRC;PIK3R1;BCAR1	ESR NR3A1;SRC1;GRB1;CAS CASS1 CRKAS
2471	SRC-PRKCD-CDCP1 complex	Human	None	None	P12931;Q05655;Q9H5V8	6714;5580;64866	MI:0019-coimmunoprecipitation	GO:0006468	protein phosphorylation	14.07.03	modification by phosphorylation, dephosphorylation, autophosphorylation	15851033	The tyrosine phosphorylation of CDCP1 by Src appears to promote the formation of a complex between CDCP1, Src, and PKC-delta.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Proto-oncogene tyrosine-protein kinase Src;Protein kinase C delta type;CUB domain-containing protein 1	SRC;PRKCD;CDCP1	SRC1;PKCD;TRASK
2476	CRK-CRKL-PDGFRA-RAPGEF1 complex	Human	CRKL-PDGFRA-CRK-RAPGEF1 complex	HeLa cells	P16234;P46108;P46109;Q13905	5156;1398;1399;2889	MI:0004-affinity chromatography technology	GO:0035556	intracellular signal transduction	30.01	cellular signalling	9546424	None	None	CrkI and CrkII are splice variants of the Crk gene, only variant CrkII has been identified as component of the complex.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Platelet-derived growth factor receptor alpha;Adapter molecule crk;Crk-like protein;Rap guanine nucleotide exchange factor 1	PDGFRA;CRK;CRKL;RAPGEF1	PDGFR2, RHEPDGFRA;None;None;GRF2
2480	CIN85 complex (CIN85, CRK, BCAR1, CBL, PIK3R1, GRB2, SOS1)	Human	None	None	P22681;P27986;P46108;P56945;P62993;Q07889;Q96B97	867;5295;1398;9564;2885;6654;30011	MI:0019-coimmunoprecipitation	GO:0007267	cell-cell signaling	None	None	11071869	The authors propose that CIN85 acts as a mediator to couple the c-Cbl signaling pathway with other pathways through its multiple protein complexes, thereby leading to their interplay.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase CBL;Phosphatidylinositol 3-kinase regulatory subunit alpha;Adapter molecule crk;Breast cancer anti-estrogen resistance protein 1;Growth factor receptor-bound protein 2;Son of sevenless homolog 1;SH3 domain-containing kinase-binding protein 1	CBL;PIK3R1;CRK;BCAR1;GRB2;SOS1;SH3KBP1	CBL2 RNF55;GRB1;None;CAS CASS1 CRKAS;ASH;None;CIN85
2486	GIPC1-LHCGR complex	Human	None	None	O14908;P22888	10755;3973	MI:0018-two hybrid;MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0006886;GO:0006605;GO:0015031;GO:0006897	intracellular protein transport;protein targeting;protein transport;endocytosis	14.04;20.01.10;20.09.18.09.01	protein targeting, sorting and translocation;protein transport;endocytosis	14507927	This protein is involved in the post-endocytotic trafficking of the internalized hCG and in maintaining the levels of cell surface hLHR during endocytosis of the bound hormone.	None	None	Homo sapiens (Human);Homo sapiens (Human)	PDZ domain-containing protein GIPC1;Lutropin-choriogonadotropic hormone receptor	GIPC1;LHCGR	C19orf3 GIPC RGS19IP1;LCGR LGR2 LHRHR
2487	GIPC1-NTRK1-RGS19 complex	Human	None	None	O14908;P04629;P49795	10755;4914;10287	MI:0019-coimmunoprecipitation	GO:0000301	retrograde transport, vesicle recycling within Golgi	20.09.07.07	retrograde transport	11251075	GIPC forms a complex with GAIP and the TrkA receptor and colocalizes with phosphoryated TrkA in retrograde transport vesicles.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	PDZ domain-containing protein GIPC1;High affinity nerve growth factor receptor;Regulator of G-protein signaling 19	GIPC1;NTRK1;RGS19	C19orf3 GIPC RGS19IP1;MTC TRK TRKA;GAIP GNAI3IP
2489	NCR3-CD247 complex	Human	None	None	O14931;P20963	259197;919	MI:0019-coimmunoprecipitation	GO:0006915	apoptotic process	40.10.02	apoptosis (type I programmed cell death)	15821739	NKp30, similar to other NK triggering receptors including CD16 (34) (35) and NKp46 (23), can transduce activating signals via association with the ITAM-containing CD3{zeta} polypeptides (PMID: 10562324).	None	None	Homo sapiens (Human);Homo sapiens (Human)	Natural cytotoxicity triggering receptor 3;T-cell surface glycoprotein CD3 zeta chain	NCR3;CD247	1C7 LY117;CD3Z T3Z TCRZ
2510	CRKL-WAS-WIPF1-ZAP70 complex	Human	ZAP70-CRKL-WIPF1-WAS complex; ZAP-70-CrkL-WIP-WASP complex	Jurkat cells	O43516;P42768;P43403;P46109	7456;7454;7535;1399	MI:0019-coimmunoprecipitation	GO:0035556;GO:0045121	intracellular signal transduction;membrane raft	30.01	cellular signalling	12504004	In unstimulated cells CrkL,WIP, and WASP exist as  a preformed complex. TCR ligation results in the formation of a ZAP-70-CrkL-WIP-WASP complex, which is recruited to lipid rafts and the immunological synapse.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	WAS/WASL-interacting protein family member 1;Actin nucleation-promoting factor WAS;Tyrosine-protein kinase ZAP-70;Crk-like protein	WIPF1;WAS;ZAP70;CRKL	WASPIP WIP;IMD2;SRK;None
2511	CRKL-WAS-WIPF1 complex	Human	CRKL-WIPF1-WAS complex; -WIP-WASP complex	Jurkat cells	O43516;P42768;P46109	7456;7454;1399	MI:0019-coimmunoprecipitation	GO:0035556	intracellular signal transduction	30.01	cellular signalling	12504004	In unstimulated cells CrkL,WIP, and WASP exist as  a preformed complex. TCR ligation results in the formation of a ZAP-70-CrkL-WIP-WASP complex, which is recruited to lipid rafts and the immunological synapse.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	WAS/WASL-interacting protein family member 1;Actin nucleation-promoting factor WAS;Crk-like protein	WIPF1;WAS;CRKL	WASPIP WIP;IMD2;None
2513	N-WASp homomer complex	Human	None	None	O00401	8976	MI:0031-protein cross-linking with a bifunctional reagent	GO:0030036	actin cytoskeleton organization	42.04.03	actin cytoskeleton	10781580	N-WASp undergoes self-association upon increasing concentration and the monomeric form activates actin polymerization and is favored by Grb2 binding.	None	None	Homo sapiens (Human)	Actin nucleation-promoting factor WASL	WASL	None
2528	ERBB2-MEMO-SHC complex	Human	None	None	P04626;P29353;Q9Y316	2064;6464;51072	MI:0019-coimmunoprecipitation	GO:0000226;GO:0048870	microtubule cytoskeleton organization;cell motility	42.04.05	microtubule cytoskeleton	15156151	The results suggest that the Shc adaptor protein mediates binding of Memo to the phospho-YD (Tyr 1227) residue of ErbB2.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Receptor tyrosine-protein kinase erbB-2;SHC-transforming protein 1;Protein MEMO1	ERBB2;SHC1;MEMO1	HER2 MLN19 NEU NGL;SHC SHCA;C2orf4 MEMO NS5ATP7
2529	LAT-PLC-gamma-1-p85-GRB2-CBL-VAV-SLP-76 signaling complex, C305 activated	Human	None	None	O43561;P15498;P19174;P22681;P27986;P62993;Q13094	27040;7409;5335;867;5295;2885;3937	MI:0019-coimmunoprecipitation	GO:0007169;GO:0050896;GO:0048015	transmembrane receptor protein tyrosine kinase signaling pathway;response to stimulus;phosphatidylinositol-mediated signaling	30.05.01.12;36.25	transmembrane receptor protein tyrosine kinase signalling pathways;animal specific systemic sensing and response	9489702	The authors show that upon tyrosine phosphorylation, LAT binds Grb2, PLC-gamma1, the p85 subunit of PI3K, and other critical signaling molecules. They provide evidence that LAT plays an important role in linking the TCR to cellular activation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Linker for activation of T-cells family member 1;Proto-oncogene vav;1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1;E3 ubiquitin-protein ligase CBL;Phosphatidylinositol 3-kinase regulatory subunit alpha;Growth factor receptor-bound protein 2;Lymphocyte cytosolic protein 2	LAT;VAV1;PLCG1;CBL;PIK3R1;GRB2;LCP2	None;VAV;PLC1;CBL2 RNF55;GRB1;ASH;None
2534	Cbl-SLP-76-Grb2 complex, Fc receptor gamma-R1 stimulated	Human	None	None	P22681;P62993;Q13094	867;2885;3937	MI:0019-coimmunoprecipitation	GO:0007169;GO:0006955	transmembrane receptor protein tyrosine kinase signaling pathway;immune response	30.05.01.12;36.25.16	transmembrane receptor protein tyrosine kinase signalling pathways;immune response	9716598	The authors demonstrate that the kinetics of SLP-76 phosphorylation parallels the kinetics of Cbl phosphorylation, suggesting a link between these two adapter proteins in the Fc gamma RI-signaling cascade.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase CBL;Growth factor receptor-bound protein 2;Lymphocyte cytosolic protein 2	CBL;GRB2;LCP2	CBL2 RNF55;ASH;None
2535	SLP-76-Cbl-Grb2-Shc complex, Fc receptor gamma-R1 stimulated	Human	None	None	P22681;P29353;P62993;Q13094	867;6464;2885;3937	MI:0019-coimmunoprecipitation	GO:0007169;GO:0006955	transmembrane receptor protein tyrosine kinase signaling pathway;immune response	30.05.01.12;36.25.16	transmembrane receptor protein tyrosine kinase signalling pathways;immune response	9716598	The authors propose that the association of Grb2 and Shc with SLP-76 and Cbl may serve as a repository for Grb2 and Shc, regulating their association with Sos and subsequent activation of Ras.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase CBL;SHC-transforming protein 1;Growth factor receptor-bound protein 2;Lymphocyte cytosolic protein 2	CBL;SHC1;GRB2;LCP2	CBL2 RNF55;SHC SHCA;ASH;None
2536	PLC-gamma-2-SLP-76-Lyn-Grb2 complex	Human	None	platelet	P07948;P16885;P62993;Q13094	4067;5336;2885;3937	MI:0096-pull down	GO:0007169;GO:0007596;GO:0048015	transmembrane receptor protein tyrosine kinase signaling pathway;blood coagulation;phosphatidylinositol-mediated signaling	30.05.01.12;36.25.16.09	transmembrane receptor protein tyrosine kinase signalling pathways;blood coagulation	10469124	Analyses done with different GST-PLC-gamma-2 fusion proteins from resting and CRP (collagen-related peptide) stimulated platelets.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Tyrosine-protein kinase Lyn;1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2;Growth factor receptor-bound protein 2;Lymphocyte cytosolic protein 2	LYN;PLCG2;GRB2;LCP2	JTK8;None;ASH;None
2537	PKC-alpha-PLD1-PLC-gamma-2 signaling complex, lacritin stimulated	Human	None	epithelium	P16885;P17252;Q13393	5336;5578;5337	MI:0006-anti bait coimmunoprecipitation	GO:0019722;GO:0030855;GO:0002009;GO:0005794;GO:0048015	calcium-mediated signaling;epithelial cell differentiation;morphogenesis of an epithelium;Golgi apparatus;phosphatidylinositol-mediated signaling	30.01.09.03;45.03.09;70.08	Ca2+ mediated signal transduction;epithelium;Golgi	16923831	Lacritin is described as mitogenic for a small subset of epithelial cell lines derived mainly from the nongermative epithelia that normally contact lacritin during its outward glandular flow. The authors propose that lacritin signaling  stimulates the formation of a transient perinuclear Golgi complex of PKC-alpha, PLD1, and PLC-gamma-2. This activates PLD1 of the mTOR pathway. Some PLC-gamma-2 activation and considerable IP3 generation were detected. Ca(2+) mobilization may then be a consequence.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2;Protein kinase C alpha type;Phospholipase D1	PLCG2;PRKCA;PLD1	None;PKCA PRKACA;None
2541	HGF-Met complex	Human	None	None	P08581;P14210	4233;3082	MI:0411-enzyme linked immunosorbent assay	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	30.05.01.12	transmembrane receptor protein tyrosine kinase signalling pathways	15161915	HGF interacts with the extracellular domain of Met, resulting in the activation of Met and subsequent downstream functions. The authors demonstrate that that copper(II) inhibits HGF/Met interaction.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Hepatocyte growth factor receptor;Hepatocyte growth factor	MET;HGF	None;HPTA
2542	EGFR-CBL-GRB2 complex	Human	None	None	P00533;P22681;P62993	1956;867;2885	MI:0055-fluorescent resonance energy transfer	GO:0035556;GO:0005768	intracellular signal transduction;endosome	30.01;70.22	cellular signalling;endosome	15782196	The energy transfer analysis results prompted the authors to support the previously proposed model that although Cbl is capable of direct binding to EGFR, it preferentially binds receptors indirectly through Grb2.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Epidermal growth factor receptor;E3 ubiquitin-protein ligase CBL;Growth factor receptor-bound protein 2	EGFR;CBL;GRB2	ERBB ERBB1 HER1;CBL2 RNF55;ASH
2547	PLC-gamma-1-SLP-76-SOS1-LAT complex	Human	None	None	O43561;P19174;Q07889;Q13094	27040;5335;6654;3937	MI:0019-coimmunoprecipitation	GO:0007169;GO:0050896;GO:0048015	transmembrane receptor protein tyrosine kinase signaling pathway;response to stimulus;phosphatidylinositol-mediated signaling	30.05.01.12;36.25	transmembrane receptor protein tyrosine kinase signalling pathways;animal specific systemic sensing and response	15696170	In a supplementary figure the authors show that PLC-gamma-1, SLP-76 and Sos1 are effectively recruited to LAT in the absence of Dyn2. The results show further that when Dyn2 was present, several tyrosine-phosphorylated proteins coimmunoprecipitated with Lat, including SLP76, PLC-gamma1 and several other unidentified proteins. PLC-gamma-1 total tyrosine phosphorylation was diminished in the absence of Dyn2.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Linker for activation of T-cells family member 1;1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1;Son of sevenless homolog 1;Lymphocyte cytosolic protein 2	LAT;PLCG1;SOS1;LCP2	None;PLC1;None;None
2551	PDGFRA-PLC-gamma-1-PI3K-SHP-2 complex, PDGF stimulated	Human	None	None	P16234;P19174;P27986;Q06124	5156;5335;5295;5781	MI:0019-coimmunoprecipitation	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	30.05.01.12	transmembrane receptor protein tyrosine kinase signalling pathways	8943348	Mutational analysis shows that Y720 of PDGFRA is required for binding of SHP-2 to the PDGFRA but not for the association of PLCg, the p85 subunit of PI3K, or Src. The data strongly suggest that SHP-2 must bind to the PDGFRA to be efficiently tyrosine phosphorylated.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Platelet-derived growth factor receptor alpha;1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1;Phosphatidylinositol 3-kinase regulatory subunit alpha;Tyrosine-protein phosphatase non-receptor type 11	PDGFRA;PLCG1;PIK3R1;PTPN11	PDGFR2, RHEPDGFRA;PLC1;GRB1;PTP2C SHPTP2
2559	p56(LCK)-CAML complex	Human	None	None	P06239;P49069	3932;819	MI:0019-coimmunoprecipitation	GO:0007169;GO:0030217	transmembrane receptor protein tyrosine kinase signaling pathway;T cell differentiation	30.05.01.12;43.03.07.02.01.02	transmembrane receptor protein tyrosine kinase signalling pathways;T-cell	16111633	The results of the authors suggest that CAML interacts with p56Lck to regulate its subcellular localization and timely activation of the kinase in response to TCR induction. They propose that CAML functions to maintain the proper storage of p56Lck to prevent excessive activation and to ensure carefully measured release of the kinase in response to TCR stimulation, thereby facilitating productive T cell activation with less cell death.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Tyrosine-protein kinase Lck;Guided entry of tail-anchored proteins factor CAMLG	LCK;CAMLG	None;CAML GET2
2563	FGFR2-c-Cbl-Lyn-Fyn complex	Human	None	None	P06241;P07948;P21802;P22681	2534;4067;2263;867	MI:0019-coimmunoprecipitation	GO:0043161;GO:0006511;GO:0023052;GO:0008543;GO:0001649	proteasome-mediated ubiquitin-dependent protein catabolic process;ubiquitin-dependent protein catabolic process;signaling;fibroblast growth factor receptor signaling pathway;osteoblast differentiation	14.13.01.01;30.01;30.05.01.12.03;43.03.17	proteasomal degradation (ubiquitin/proteasomal pathway);cellular signalling;FGF-receptor signalling pathway;structural cell of tissue (fibroblast, osteoblast, etc.)	15190072	The results indicate that FGFR2 interacts with Lyn and Fyn and with c-Cbl, which can then mediate proteasome degradation of these three molecules in osteoblasts. The authors propose a mechanism by which constitutive FGFR2 activation in osteoblasts induces c-Cbl-dependent recruitment of FGFR2, Lyn, and Fyn, leading to their proteasome degradation, decreased kinase activity, and hence increased osteoblast differentiation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Tyrosine-protein kinase Fyn;Tyrosine-protein kinase Lyn;Fibroblast growth factor receptor 2;E3 ubiquitin-protein ligase CBL	FYN;LYN;FGFR2;CBL	None;JTK8;BEK KGFR KSAM;CBL2 RNF55
2564	p21(ras)GAP-Fyn-Lyn-Yes complex, thrombin stimulated	Human	None	platelet	P06241;P07947;P07948;P20936	2534;7525;4067;5921	MI:0019-coimmunoprecipitation	GO:0023052;GO:0007596	signaling;blood coagulation	30.01;36.25.16.09	cellular signalling;blood coagulation	1544885	The authors showed that Fyn, Lyn,and Yes are associated with GAP in thrombin-stimulatedplatelets. They could not distinguish whether this complex is preformed in restingplatelets or whether the kinases associate with GAP followingactivation with thrombin.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Tyrosine-protein kinase Fyn;Tyrosine-protein kinase Yes;Tyrosine-protein kinase Lyn;Ras GTPase-activating protein 1	FYN;YES1;LYN;RASA1	None;YES;JTK8;GAP RASA
2565	CD20-LCK-LYN-FYN-p75/80 complex, (Raji human B cell line)	Human	None	Raji cells	P06239;P06241;P07948;P11836	3932;2534;4067;931	MI:0019-coimmunoprecipitation	GO:0023052	signaling	30.01	cellular signalling	7545683	Lyn accounted for most of the PTK activity in the CD20 complex.	None	At the time of annotation, the identity of the additional member p75/80 of the protein complex was not known.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Tyrosine-protein kinase Lck;Tyrosine-protein kinase Fyn;Tyrosine-protein kinase Lyn;B-lymphocyte antigen CD20	LCK;FYN;LYN;MS4A1	None;None;JTK8;CD20
2572	RAB5-EEA1 complex	Human	None	None	P20339;Q15075	5868;8411	MI:0055-fluorescent resonance energy transfer	GO:0006897;GO:0005768	endocytosis;endosome	20.09.18.09.01;70.22	endocytosis;endosome	15782196	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Ras-related protein Rab-5A;Early endosome antigen 1	RAB5A;EEA1	RAB5;ZFYVE2
2573	Class C VPS/HOPS complex	Human	None	HeLa cells	P20339;Q15075;Q96JC1;Q9H269;Q9H270;Q9P253	5868;8411;23339;64601;55823;57617	MI:0004-affinity chromatography technology	GO:0006897;GO:0007032;GO:0005768	endocytosis;endosome organization;endosome	20.09.18.09.01;42.22;70.22	endocytosis;endosome;endosome	16143105	The class C VPS/HOPS complex, an established GEF for Rab7, interacts with Rab5 and is required for Rab5-to-Rab7 conversion.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Ras-related protein Rab-5A;Early endosome antigen 1;Vam6/Vps39-like protein;Vacuolar protein sorting-associated protein 16 homolog;Vacuolar protein sorting-associated protein 11 homolog;Vacuolar protein sorting-associated protein 18 homolog	RAB5A;EEA1;VPS39;VPS16;VPS11;VPS18	RAB5;ZFYVE2;KIAA0770 TLP VAM6;None;RNF108;KIAA1475
2574	CD19-VAV1-PIK3R1 complex	Human	CD19-Vav-PI 3-kinase (p85 subunit) complex	early B-lineage cells	P15391;P15498;P27986	930;7409;5295	MI:0019-coimmunoprecipitation	GO:0030183;GO:0048015;GO:0050776	B cell differentiation;phosphatidylinositol-mediated signaling;regulation of immune response	43.03.07.02.01.01	B-cell	7528218	The authors show that cross-linking of CD19 on surface Ig-negative B cell precursors and surface Ig-positive immature B cells results in the rapid tyrosine phosphorylation of Vav and a concomitant physical association of Vav with CD19 and PI 3-kinase.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	B-lymphocyte antigen CD19;Proto-oncogene vav;Phosphatidylinositol 3-kinase regulatory subunit alpha	CD19;VAV1;PIK3R1	None;VAV;GRB1
2577	Sam68-p85 P13K-IRS-1-IR signaling complex	Human	None	None	P06213;P27986;P35568;Q07666	3643;5295;3667;10657	MI:0019-coimmunoprecipitation	GO:0008286;GO:0005737	insulin receptor signaling pathway;cytoplasm	30.05.01.12.05;70.03	insulin receptor signalling pathway;cytoplasm	11604231	The authors found that Sam68 is tyrosine phosphorylated and associates with p85 PI3K after insulin stimulation in a complex that also contains IRS-1 and the IR itself. Further they demonstrated that Sam68 relocalizes after insulin stimulation from the nucleus to the cytoplasm. Regarding the association of Sam68 with p120GAP it is concluded that Sam68 is linking p120GAP to P13K signaling pathway.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Insulin receptor;Phosphatidylinositol 3-kinase regulatory subunit alpha;Insulin receptor substrate 1;KH domain-containing, RNA-binding, signal transduction-associated protein 1	INSR;PIK3R1;IRS1;KHDRBS1	None;GRB1;None;SAM68
2578	Sam68-p120GAP complex	Human	None	None	P20936;Q07666	5921;10657	MI:0019-coimmunoprecipitation	GO:0008286;GO:0005737	insulin receptor signaling pathway;cytoplasm	30.05.01.12.05;70.03	insulin receptor signalling pathway;cytoplasm	11604231	The authors suggest that Sam68 is associated with p120GAP after insulin stimulation and in this way it links GAP to the PI3K pathway. Further they demonstrated that Sam68 relocalizes after insulin stimulation from the nucleus to the cytoplasm.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Ras GTPase-activating protein 1;KH domain-containing, RNA-binding, signal transduction-associated protein 1	RASA1;KHDRBS1	GAP RASA;SAM68
2579	Chromosomal passenger complex CPC (INCENP, BIRC5, AURKB)	Human	None	HeLa S3 cells	O15392;Q96GD4;Q9NQS7	332;9212;3619	MI:0096-pull down;MI:0416-fluorescence microscopy	GO:0000278;GO:0051225;GO:0007059;GO:0000775	mitotic cell cycle;spindle assembly;chromosome segregation;chromosome, centromeric region	10.03.01.01;10.03.05.01;10.03.04.05;70.10.04	mitotic cell cycle;spindle pole body/centrosome and microtubule cycle;chromosome segregation/division;centromere / kinetochore	12925766	All three proteins showed very similar changes in cell cycle progression, low in G1/S, increased during G2 and M. The studies revealed an evolutionarily conserved mechanism for Aurora B activation by INCENP binding and phosphorylation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Baculoviral IAP repeat-containing protein 5;Aurora kinase B;Inner centromere protein	BIRC5;AURKB;INCENP	API4 IAP4;AIK2 AIM1 AIRK2 ARK2 STK1 STK12 STK5;None
2580	Survivin homodimer complex	Human	None	None	O15392	332	MI:0114-x-ray crystallography	GO:0000279;GO:0051225;GO:0007098;GO:0043066;GO:0000226;GO:0015630;GO:0000278	M phase;spindle assembly;centrosome cycle;negative regulation of apoptotic process;microtubule cytoskeleton organization;microtubule cytoskeleton;mitotic cell cycle	10.03.01.01.11;10.03.05.01;40.10.02.01;42.04.05;70.04.05;10.03.01.01	M phase;spindle pole body/centrosome and microtubule cycle;anti-apoptosis;microtubule cytoskeleton;microtubule cytoskeleton;mitotic cell cycle	10876248	Survivin temporally and spatially localizes to microtubule organizing centers (MTOC) during mitosis (PMID:9859993).	None	None	Homo sapiens (Human)	Baculoviral IAP repeat-containing protein 5	BIRC5	API4 IAP4
2581	RasGAP-AURKA-survivin complex	Human	None	HeLa cells	O14965;O15392;P20936	6790;332;5921	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0000278;GO:0051726;GO:0007186	mitotic cell cycle;regulation of cell cycle;G protein-coupled receptor signaling pathway	10.03.01.01;10.03.01;30.05.02.24	mitotic cell cycle;mitotic cell cycle and cell cycle control;G-protein coupled receptor signalling pathway	11976319	The authors define this ternary complex by several protein-protein interactions. RasGAP binds to the kinase domain of Aurora and this interaction inhibits the kinase activity of AURKA and AURKB.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Aurora kinase A;Baculoviral IAP repeat-containing protein 5;Ras GTPase-activating protein 1	AURKA;BIRC5;RASA1	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6;API4 IAP4;GAP RASA
2582	Chromosomal passenger complex CPC (CDCA8, AURKB, BIRC5)	Human	None	None	O15392;Q53HL2;Q96GD4	332;55143;9212	MI:0006-anti bait coimmunoprecipitation	GO:0000278;GO:0051225;GO:0000775;GO:0007059	mitotic cell cycle;spindle assembly;chromosome, centromeric region;chromosome segregation	10.03.01.01;10.03.05.01;70.10.04;10.03.04.05	mitotic cell cycle;spindle pole body/centrosome and microtubule cycle;centromere / kinetochore;chromosome segregation/division	15260989	The authors propose that Dasra B may act to regulate the stability of Survivin, which, together with Incenp, serves to target Aurora B to chromosomal arms and centromeres.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Baculoviral IAP repeat-containing protein 5;Borealin;Aurora kinase B	BIRC5;CDCA8;AURKB	API4 IAP4;PESCRG3;AIK2 AIM1 AIRK2 ARK2 STK1 STK12 STK5
2589	PGC-1-SRp40-SRp55-SRp75 complex	Human	None	None	Q08170;Q13243;Q13247;Q9UBK2	6429;6430;6431;10891	MI:0007-anti tag coimmunoprecipitation	GO:2001141;GO:0006355;GO:0000398;GO:0006397;GO:0003676;GO:0005634	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;mRNA splicing, via spliceosome;mRNA processing;nucleic acid binding;nucleus	11.02.03.04;11.04.03;16.03;70.10	transcriptional control;mRNA processing (splicing, 5'-, 3'-end processing);nucleic acid binding;nucleus	10983978	PGC-1 is part of both the preinitiation and elongation Pol II complexes, and association with the elongation form of Pol II depends on the C-terminal domain of PGC-1.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Serine/arginine-rich splicing factor 4;Serine/arginine-rich splicing factor 5;Serine/arginine-rich splicing factor 6;Peroxisome proliferator-activated receptor gamma coactivator 1-alpha	SRSF4;SRSF5;SRSF6;PPARGC1A	SFRS4 SRP75;HRS SFRS5 SRP40;SFRS6, SRP55;LEM6 PGC1 PGC1A PPARGC1
2590	FOXO1-FHL2-SIRT1 complex	Human	None	None	Q12778;Q14192;Q96EB6	2308;2274;23411	MI:0019-coimmunoprecipitation	GO:0045892;GO:0006473;GO:0006476;GO:0005634	negative regulation of DNA-templated transcription;protein acetylation;protein deacetylation;nucleus	11.02.03.04.03;14.07.04;70.10	transcription repression;modification by acetylation, deacetylation;nucleus	15692560	The authors came to the following results: 1. FHL2 colocalizes and interacts with FOXO1 in prostate cancer cells. 2. FHL2 inhibits the activation of an IRS-driven reporter gene by FOXO1 in the presence but not in the absence of SIRT1 activity. 3. SIRT1 binds FOXO1, decreases its acetylation, and inhibits its transcriptional activity. 4. FHL2 interacts with SIRT1 and promotes its interaction with FOXO1. They suggest a model  that FHL2 negates the transcriptional activity of FOXO1 by promoting its deacetylation by SIRT1.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Forkhead box protein O1;Four and a half LIM domains protein 2;NAD-dependent protein deacetylase sirtuin-1	FOXO1;FHL2;SIRT1	FKHR FOXO1A;DRAL SLIM3;SIR2L1
2592	SIRT1 homotrimer complex	Human	None	HeLaS3 cells	Q96EB6	23411	MI:0071-molecular sieving	GO:0006476;GO:0005634;GO:0031507	protein deacetylation;nucleus;heterochromatin formation	14.07.04;70.10	modification by acetylation, deacetylation;nucleus	15469825	SirT1 exists as a trimer and interacts with histone H1.	None	None	Homo sapiens (Human)	NAD-dependent protein deacetylase sirtuin-1	SIRT1	SIR2L1
2593	FOXO3-SIRT1 complex, oxidative stress stimulated	Human	None	None	O43524;Q96EB6	2309;23411	MI:0006-anti bait coimmunoprecipitation;MI:0007-anti tag coimmunoprecipitation	GO:2001141;GO:0006355;GO:0000302;GO:0006979;GO:0043066;GO:0005634	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;response to reactive oxygen species;response to oxidative stress;negative regulation of apoptotic process;nucleus	11.02.03.04;32.01.01;40.10.02.01;70.10	transcriptional control;oxidative stress response;anti-apoptosis;nucleus	14976264	SIRT1 and  transcription factor FOXO3 formed a complex in cells in response to oxidative stress, and SIRT1 deacetylated FOXO3 in vitro and within cells. SIRT1 increased FOXO3's ability to induce cell cycle arrest and resistance to oxidative stress but inhibited FOXO3's ability to induce cell death.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Forkhead box protein O3;NAD-dependent protein deacetylase sirtuin-1	FOXO3;SIRT1	FKHRL1, FOXO3A;SIR2L1
2598	NELF complex	Human	Negative elongation factor complex	None	P18615;Q8IXH7;Q8WX92;Q9H3P2	7936;51497;25920;7469	MI:0007-anti tag coimmunoprecipitation	GO:0006354;GO:0045892;GO:0003723;GO:0051090;GO:0005634	DNA-templated transcription elongation;negative regulation of DNA-templated transcription;RNA binding;regulation of DNA-binding transcription factor activity;nucleus	11.02.03.01.04;11.02.03.04.03;16.03.03;18.02.09;70.10	transcription elongation;transcription repression;RNA binding;regulator of transcription factor;nucleus	12612062	NELF cooperates with DSIF and represses DRB-sensitive RNA-Polymerase II.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Negative elongation factor E;Negative elongation factor C/D;Negative elongation factor B;Negative elongation factor A	NELFE;NELFCD;NELFB;NELFA	RD, RDBP;NELFD TH1 TH1L;COBRA1 KIAA1182;WHSC2
2599	POLR2A-CCNT1-CDK9-NCL-LEM6-CPSF2 complex	Human	None	None	O60563;P19338;P24928;P50750;Q9P2I0;Q9UBK2	904;4691;5430;1025;53981;10891	MI:0007-anti tag coimmunoprecipitation	GO:0006355;GO:0000398;GO:0006397;GO:0006468;GO:0003676;GO:0005634	regulation of DNA-templated transcription;mRNA splicing, via spliceosome;mRNA processing;protein phosphorylation;nucleic acid binding;nucleus	11.02.03.04;11.04.03;14.07.03;16.03;70.10	transcriptional control;mRNA processing (splicing, 5'-, 3'-end processing);modification by phosphorylation, dephosphorylation, autophosphorylation;nucleic acid binding;nucleus	10983978	The authors demonstrate that PGC-1 is part of both the preinitiation and elongation Pol II complexes, and association with the elongation form of Pol II depends on the C-terminal domain of PGC-1.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cyclin-T1;Nucleolin;DNA-directed RNA polymerase II subunit RPB1;Cyclin-dependent kinase 9;Cleavage and polyadenylation specificity factor subunit 2;Peroxisome proliferator-activated receptor gamma coactivator 1-alpha	CCNT1;NCL;POLR2A;CDK9;CPSF2;PPARGC1A	None;None;POLR2;CDC2L4 TAK;CPSF100, KIAA1367;LEM6 PGC1 PGC1A PPARGC1
2600	BRD4 complex	Human	None	None	O60244;O60563;O60885;O75448;P50750;Q15648;Q93074;Q9NVC6	9282;904;23476;9862;1025;5469;9968;9440	MI:0676-tandem affinity purification	GO:0006354;GO:0045893;GO:0005634;GO:0070816	DNA-templated transcription elongation;positive regulation of DNA-templated transcription;nucleus;phosphorylation of RNA polymerase II C-terminal domain	11.02.03.01.04;11.02.03.04.01;70.10	transcription elongation;transcription activation;nucleus	16109376	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mediator of RNA polymerase II transcription subunit 14;Cyclin-T1;Bromodomain-containing protein 4;Mediator of RNA polymerase II transcription subunit 24;Cyclin-dependent kinase 9;Mediator of RNA polymerase II transcription subunit 1;Mediator of RNA polymerase II transcription subunit 12;Mediator of RNA polymerase II transcription subunit 17	MED14;CCNT1;BRD4;MED24;CDK9;MED1;MED12;MED17	ARC150 CRSP2 CXorf4 DRIP150 EXLM1 RGR1 TRAP170;None;HUNK1;ARC100 CRSP4 DRIP100 KIAA0130 THRAP4 TRAP100;CDC2L4 TAK;ARC205 CRSP1 CRSP200 DRIP205 DRIP230 PBP PPARBP PPARGBP RB18A TRAP220 TRIP2;ARC240 CAGH45 HOPA KIAA0192 TNRC11 TRAP230;ARC77 CRSP6 DRIP77 DRIP80 TRAP80
2601	P-TEFb-BRD4-TRAP220 complex	Human	None	None	O60563;O60885;P50750;Q15648	904;23476;1025;5469	MI:0007-anti tag coimmunoprecipitation	GO:0006354;GO:0045893;GO:0005634;GO:0070816	DNA-templated transcription elongation;positive regulation of DNA-templated transcription;nucleus;phosphorylation of RNA polymerase II C-terminal domain	11.02.03.01.04;11.02.03.04.01;70.10	transcription elongation;transcription activation;nucleus	16109377	Brd4 is necessary to mediate the interaction between P-TEFb and Mediator complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cyclin-T1;Bromodomain-containing protein 4;Cyclin-dependent kinase 9;Mediator of RNA polymerase II transcription subunit 1	CCNT1;BRD4;CDK9;MED1	None;HUNK1;CDC2L4 TAK;ARC205 CRSP1 CRSP200 DRIP205 DRIP230 PBP PPARBP PPARGBP RB18A TRAP220 TRIP2
2604	P-TEFb-SKP2 complex	Human	None	None	O60563;P50750;Q13309	904;1025;6502	MI:0019-coimmunoprecipitation	GO:0006354;GO:2001141;GO:0006355;GO:0043161;GO:0006511;GO:0005634	DNA-templated transcription elongation;regulation of RNA biosynthetic process;regulation of DNA-templated transcription;proteasome-mediated ubiquitin-dependent protein catabolic process;ubiquitin-dependent protein catabolic process;nucleus	11.02.03.01.04;11.02.03.04;14.13.01.01;70.10	transcription elongation;transcriptional control;proteasomal degradation (ubiquitin/proteasomal pathway);nucleus	11689688	Binding of SKP2 to P-TEFb requires PEST domain of cyclin T1. CDK9 is ubiquitinated and degraded by the proteasome whereas cyclin T1 is stable.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cyclin-T1;Cyclin-dependent kinase 9;S-phase kinase-associated protein 2	CCNT1;CDK9;SKP2	None;CDC2L4 TAK;FBXL1
2605	CCNT1-GRN complex	Human	Heterotrimeric complex (CCNT1, CDK9, GRN)	HeLa cells; 293 cell extract	O60563;P28799	904;2896	MI:0018-two hybrid;MI:0019-coimmunoprecipitation	GO:0045892;GO:0008083	negative regulation of DNA-templated transcription;growth factor activity	11.02.03.04.03;40.02.03.05	transcription repression;growth factors	12588988	Granulin was identified as a cyclin T1-interacting protein that represses expression from the HIV-1 promoter in transfected cells. It is shown that granulin formed stable complexes in vivo and in vitro with cyclin T1 and Tat. Granulin was a substrate for CDK9 but not for the other transcription-related kinases CDK7 and CDK8. Thus, granulin is a cellular protein that interacts with cyclin T1 to inhibit transcription.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cyclin-T1;Progranulin	CCNT1;GRN	None;None
2625	CDK8-MED6-PARP1 complex	Human	None	None	O75586;P09874;P49336	10001;142;1024	MI:0019-coimmunoprecipitation	GO:2001141;GO:0006355	regulation of RNA biosynthetic process;regulation of DNA-templated transcription	11.02.03.04	transcriptional control	15808511	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mediator of RNA polymerase II transcription subunit 6;Poly [ADP-ribose] polymerase 1;Cyclin-dependent kinase 8	MED6;PARP1;CDK8	ARC33;ADPRT PPOL;None
2626	CCNC-CDK8-MED1-MED6-MED7 xcomplex	Human	None	None	O43513;O75586;P24863;P49336;Q15648	9443;10001;892;1024;5469	MI:0019-coimmunoprecipitation	GO:2001141;GO:0006355	regulation of RNA biosynthetic process;regulation of DNA-templated transcription	11.02.03.04	transcriptional control	15808511	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mediator of RNA polymerase II transcription subunit 7;Mediator of RNA polymerase II transcription subunit 6;Cyclin-C;Cyclin-dependent kinase 8;Mediator of RNA polymerase II transcription subunit 1	MED7;MED6;CCNC;CDK8;MED1	ARC34 CRSP9;ARC33;None;None;ARC205 CRSP1 CRSP200 DRIP205 DRIP230 PBP PPARBP PPARGBP RB18A TRAP220 TRIP2
2628	CCNC-CDK3 complex	Human	None	None	P24863;Q00526	892;1018	MI:0019-coimmunoprecipitation	GO:0007049	cell cycle	10.03	cell cycle	15084261	A non-cdk8-associated cellular pool of cyclin C combines with cdk3 to stimulate pRb phosphorylation at S807/811 during the G0/G1 transition, and that this phosphorylation is required for cells to exit G0 efficiently.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cyclin-C;Cyclin-dependent kinase 3	CCNC;CDK3	None;CDKN3
2638	HES1 promoter corepressor complex	Human	None	None	P24928;P50613;Q06330;Q09472;Q7KZ85;Q92793	5430;1022;3516;2033;6830;1387	MI:0402-chromatin immunoprecipitation assay	GO:0045892;GO:0003677;GO:0005634	negative regulation of DNA-templated transcription;DNA binding;nucleus	11.02.03.04.03;16.03.01;70.10	transcription repression;DNA binding;nucleus	15546612	This complex has been studied on the HES1 promoter (a Notch target gene) in cells without Notch signaling.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA-directed RNA polymerase II subunit RPB1;Cyclin-dependent kinase 7;Recombining binding protein suppressor of hairless;Histone acetyltransferase p300;Transcription elongation factor SPT6;CREB-binding protein	POLR2A;CDK7;RBPJ;EP300;SUPT6H;CREBBP	POLR2;CAK CAK1 CDKN7 MO15 STK1;IGKJRB IGKJRB1 RBPJK RBPSUH;P300;KIAA0162 SPT6H;CBP
2639	HES1 promoter-Notch enhancer complex	Human	None	None	O60563;P24928;P46531;P49336;P50613;P50750;Q06330;Q09472;Q15648;Q7KZ85;Q92585;Q9BT40;Q9Y5B9	904;5430;4851;1024;1022;1025;3516;2033;5469;6830;9794;51763;11198	MI:0402-chromatin immunoprecipitation assay	GO:0045893;GO:0003677;GO:0007219;GO:0005634	positive regulation of DNA-templated transcription;DNA binding;Notch signaling pathway;nucleus	11.02.03.04.01;16.03.01;30.05.02.14;70.10	transcription activation;DNA binding;Notch-receptor signalling pathway;nucleus	15546612	After Notch signaling endogenous CDK8 is recruited to the HES1 promoter (a Notch target gene) together with Notch and MAM. Signaling also induces binding of SKIP, as well as two transcription elongation factors, P-TEFb and FACT.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cyclin-T1;DNA-directed RNA polymerase II subunit RPB1;Neurogenic locus notch homolog protein 1;Cyclin-dependent kinase 8;Cyclin-dependent kinase 7;Cyclin-dependent kinase 9;Recombining binding protein suppressor of hairless;Histone acetyltransferase p300;Mediator of RNA polymerase II transcription subunit 1;Transcription elongation factor SPT6;Mastermind-like protein 1;Inositol polyphosphate 5-phosphatase K;FACT complex subunit SPT16	CCNT1;POLR2A;NOTCH1;CDK8;CDK7;CDK9;RBPJ;EP300;MED1;SUPT6H;MAML1;INPP5K;SUPT16H	None;POLR2;TAN1;None;CAK CAK1 CDKN7 MO15 STK1;CDC2L4 TAK;IGKJRB IGKJRB1 RBPJK RBPSUH;P300;ARC205 CRSP1 CRSP200 DRIP205 DRIP230 PBP PPARBP PPARGBP RB18A TRAP220 TRIP2;KIAA0162 SPT6H;KIAA0200;PPS SKIP;FACT140 FACTP140
2641	CREBBP-KAT2B-MYOD1 complex	Human	p300/CBP-PCAF-MyoD complex	C2C12 myotube	P15172;Q92793;Q92831	4654;1387;8850	MI:0019-coimmunoprecipitation	GO:0007519;GO:0006351	skeletal muscle tissue development;DNA-templated transcription	41.05.15;11	myogenesis;TRANSCRIPTION	9659901	None	None	The transcriptional coactivators p300 and CBP are considered as functional homologs, the authors refer to them as p300/CBP. We used CBP.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Myoblast determination protein 1;CREB-binding protein;Histone acetyltransferase KAT2B	MYOD1;CREBBP;KAT2B	BHLHC1 MYF3 MYOD;CBP;PCAF
2642	SMAD1-P300 complex	Human	None	None	Q09472;Q15797	2033;4086	MI:0007-anti tag coimmunoprecipitation;MI:0402-chromatin immunoprecipitation assay	GO:0006265;GO:0045893;GO:0006473;GO:0007179;GO:0051276;GO:0005634	DNA topological change;positive regulation of DNA-templated transcription;protein acetylation;transforming growth factor beta receptor signaling pathway;chromosome organization;nucleus	10.01.09.05;11.02.03.04.01;14.07.04;30.05.01.18.01;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription activation;modification by acetylation, deacetylation;TGF-beta-receptor signalling pathway;organization of chromosome structure;nucleus	10673036	SMAD1 stimulates transcription cooperatively with P300.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Histone acetyltransferase p300;Mothers against decapentaplegic homolog 1	EP300;SMAD1	P300;BSP1 MADH1 MADR1
2649	MYC-DNMT3A-ZBTB17 complex	Human	None	None	P01106;Q13105;Q9Y6K1	4609;None;1788	MI:0019-coimmunoprecipitation	GO:2001141;GO:0006355;GO:0003677	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;DNA binding	11.02.03.04;16.03.01	transcriptional control;DNA binding	15616584	This complex is involved in a transcriptional silencing of  p21Cip1 promoter.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Myc proto-oncogene protein;Zinc finger and BTB domain-containing protein 17;DNA	MYC;ZBTB17;DNMT3A	BHLHE39;MIZ1 ZNF151 ZNF60;None
2650	DNMT3B-DNMT3L complex	Human	None	None	Q9UBC3;Q9UJW3	1789;29947	MI:0071-molecular sieving	GO:0006306	DNA methylation	10.01.09.01	DNA methylation	15105426	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	DNA;DNA	DNMT3B;DNMT3L	None;None
2651	DNMT3L-DNMT3A complex	Human	None	None	Q9UJW3;Q9Y6K1	29947;1788	MI:0071-molecular sieving	GO:0006306	DNA methylation	10.01.09.01	DNA methylation	15105426	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	DNA;DNA	DNMT3L;DNMT3A	None;None
2653	MYC-MAX-KAT2A-TRRAP complex	Human	c-Myc-MAX-GCN5-TRRAP complex	293 cell lysates	P01106;P61244;Q92830;Q9Y4A5	4609;4149;2648;8295	MI:0019-coimmunoprecipitation	GO:0016573;GO:0006338;GO:0006351	histone acetylation;chromatin remodeling;DNA-templated transcription	11	TRANSCRIPTION	10611234	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Myc proto-oncogene protein;Protein max;Histone acetyltransferase KAT2A;Transformation/transcription domain-associated protein	MYC;MAX;KAT2A;TRRAP	BHLHE39;BHLHD4;GCN5 GCN5L2;PAF400
2657	ESR1-CDK7-CCNH-MNAT1-MTA1-HDAC2 complex	Human	None	None	P03372;P50613;P51946;P51948;Q13330;Q92769	2099;1022;902;4331;9112;3066	MI:0019-coimmunoprecipitation	GO:2001141;GO:0006355;GO:0006468;GO:0005634;GO:0033146	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;protein phosphorylation;nucleus;regulation of intracellular estrogen receptor signaling pathway	11.02.03.04;14.07.03;70.10	transcriptional control;modification by phosphorylation, dephosphorylation, autophosphorylation;nucleus	12527756	The authors identified MAT1 as a target of corepressor MTA1 and provided new evidence to suggest that the transactivation functions of ER are influenced by the regulatory interactions between CAK and MTA1.	MTA1 is involved in metastasis or cancer formation.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Estrogen receptor;Cyclin-dependent kinase 7;Cyclin-H;CDK-activating kinase assembly factor MAT1;Metastasis-associated protein MTA1;Histone deacetylase 2	ESR1;CDK7;CCNH;MNAT1;MTA1;HDAC2	ESR NR3A1;CAK CAK1 CDKN7 MO15 STK1;None;CAP35 MAT1 RNF66;None;None
2670	Er-alpha-p53-hdm2 complex	Human	None	None	P03372;P04637;Q00987	2099;7157;4193	MI:0096-pull down	GO:0030234;GO:0050790	enzyme regulator activity;regulation of catalytic activity	18.02.01	enzymatic activity regulation / enzyme regulator	10766163	The authors demonstrated that ER-alpha protects p53 from being deactivated by hdm2 in a Luc reporter assay.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Estrogen receptor;Cellular tumor antigen p53;E3 ubiquitin-protein ligase Mdm2	ESR1;TP53;MDM2	ESR NR3A1;P53;None
2678	FOXO3-TP53 complex, oxidative stress stimulated	Human	None	None	O43524;P04637	2309;7157	MI:0019-coimmunoprecipitation	GO:2001141;GO:0006355;GO:0000302;GO:0006979;GO:0005634	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;response to reactive oxygen species;response to oxidative stress;nucleus	11.02.03.04;32.01.01;70.10	transcriptional control;oxidative stress response;nucleus	14976264	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Forkhead box protein O3;Cellular tumor antigen p53	FOXO3;TP53	FKHRL1, FOXO3A;P53
2679	p53-SP1 complex	Human	None	None	P04637;P08047	7157;6667	MI:0006-anti bait coimmunoprecipitation	GO:2001141;GO:0006355;GO:0003677;GO:0005634	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;DNA binding;nucleus	11.02.03.04;16.03.01;70.10	transcriptional control;DNA binding;nucleus	15674334	The authors provide evidence that p53 repressed the RECQ4 promoter by forming a complex with the transcription factor, SP1, and by regulating promoter occupancy of both itself and SP1 in concert with histone deacetylase 1 (HDAC1). The formation of this complex is camptothecin-dependent.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cellular tumor antigen p53;Transcription factor Sp1	TP53;SP1	P53;TSFP1
2681	p53 homotetramer complex	Human	None	None	P04637	7157	MI:0031-protein cross-linking with a bifunctional reagent;MI:0276-blue native page	GO:2001141;GO:0006355;GO:0003677;GO:0005634	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;DNA binding;nucleus	11.02.03.04;16.03.01;70.10	transcriptional control;DNA binding;nucleus	15674341	The results demonstrate that Ref-1 (redox factor 1) modulates p53 DNA binding not only as a redox regulator but also as a factor, which facilitates the formation of p53 tetramers from higher oligomeric forms as well as from dimers. Ref-1 mediates de-stacking of higher oligomeric forms into individual tetramers, as well as the assembly of dimers into tetramers. Redox-dependent and redox-independent activation of p53 seem to require different amounts of Ref-1.	None	None	Homo sapiens (Human)	Cellular tumor antigen p53	TP53	P53
2685	RNA polymerase II (RNAPII)	Human	None	None	O15514;P13984;P19387;P19388;P24928;P30876;P35269;P36954;P52434;P52435;P53803;P61218;P62487;P62875;Q00403;Q9BWH6;Q9Y5B0	5433;2963;5432;5434;5430;5431;2962;5438;5437;5439;5440;5435;5436;5441;2959;26015;9150	MI:0004-affinity chromatography technology;MI:0069-mass spectrometry studies of complexes	GO:0006351;GO:0003677;GO:0005634	DNA-templated transcription;DNA binding;nucleus	11;16.03.01;70.10	TRANSCRIPTION;DNA binding;nucleus	15282305	The authors demonstrate the purification of a functionally active human RNAPII by the use of doubly tagged subunits expressed in mammalian cells.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA-directed RNA polymerase II subunit RPB4;General transcription factor IIF subunit 2;DNA-directed RNA polymerase II subunit RPB3;DNA-directed RNA polymerases I, II, and III subunit RPABC1;DNA-directed RNA polymerase II subunit RPB1;DNA-directed RNA polymerase II subunit RPB2;General transcription factor IIF subunit 1;DNA-directed RNA polymerase II subunit RPB9;DNA-directed RNA polymerases I, II, and III subunit RPABC3;DNA-directed RNA polymerase II subunit RPB11-a;DNA-directed RNA polymerases I, II, and III subunit RPABC4;DNA-directed RNA polymerases I, II, and III subunit RPABC2;DNA-directed RNA polymerase II subunit RPB7;DNA-directed RNA polymerases I, II, and III subunit RPABC5;Transcription initiation factor IIB;RNA polymerase II-associated protein 1;RNA polymerase II subunit A C-terminal domain phosphatase	POLR2D;GTF2F2;POLR2C;POLR2E;POLR2A;POLR2B;GTF2F1;POLR2I;POLR2H;POLR2J;POLR2K;POLR2F;POLR2G;POLR2L;GTF2B;RPAP1;CTDP1	None;RAP30;None;None;POLR2;None;RAP74;None;None;POLR2J1;None;POLRF;RPB7;None;TF2B TFIIB;KIAA1403;FCP1
2686	BRCA1-core RNA polymerase II complex	Human	None	None	O15514;P19387;P19388;P24928;P30876;P36954;P38398;P52434;P52435;P53803;P61218;P62487;P62875	5433;5432;5434;5430;5431;5438;672;5437;5439;5440;5435;5436;5441	MI:0004-affinity chromatography technology	GO:0006351;GO:0003677;GO:0005634	DNA-templated transcription;DNA binding;nucleus	11;16.03.01;70.10	TRANSCRIPTION;DNA binding;nucleus	10725406	The transcriptional coactivator BRCA1 interacts directly with the core Pol II complex in vitro.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA-directed RNA polymerase II subunit RPB4;DNA-directed RNA polymerase II subunit RPB3;DNA-directed RNA polymerases I, II, and III subunit RPABC1;DNA-directed RNA polymerase II subunit RPB1;DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase II subunit RPB9;Breast cancer type 1 susceptibility protein;DNA-directed RNA polymerases I, II, and III subunit RPABC3;DNA-directed RNA polymerase II subunit RPB11-a;DNA-directed RNA polymerases I, II, and III subunit RPABC4;DNA-directed RNA polymerases I, II, and III subunit RPABC2;DNA-directed RNA polymerase II subunit RPB7;DNA-directed RNA polymerases I, II, and III subunit RPABC5	POLR2D;POLR2C;POLR2E;POLR2A;POLR2B;POLR2I;BRCA1;POLR2H;POLR2J;POLR2K;POLR2F;POLR2G;POLR2L	None;None;None;POLR2;None;None;RNF53;None;POLR2J1;None;POLRF;RPB7;None
2688	CLDN1-MMP14 complex	Human	MT1-MMP-claudin-1 complex	293T cells	O95832;P50281	9076;4323	MI:0006-anti bait coimmunoprecipitation	GO:1905050;GO:0045216	positive regulation of metallopeptidase activity;cell-cell junction organization	42.06.04	intercellular junction (gap junction/adherens junction)	11382769	Claudin-5 was identified to promote the activation of pro-MMP-2 mediated by MT1-MMP in 293T cells.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Claudin-1;Matrix metalloproteinase-14	CLDN1;MMP14	CLD1 SEMP1;None
2692	SMAD3-SMAD4-cJun-cFos complex	Human	None	None	P01100;P05412;P84022;Q13485	2353;3725;4088;4089	MI:0412-electrophoretic mobility supershift assay	GO:0045893;GO:0003677;GO:0007179;GO:0005634	positive regulation of DNA-templated transcription;DNA binding;transforming growth factor beta receptor signaling pathway;nucleus	11.02.03.04.01;16.03.01;30.05.01.18.01;70.10	transcription activation;DNA binding;TGF-beta-receptor signalling pathway;nucleus	9732876	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein c-Fos;Transcription factor Jun;Mothers against decapentaplegic homolog 3;Mothers against decapentaplegic homolog 4	FOS;JUN;SMAD3;SMAD4	G0S7;None;MADH3;DPC4 MADH4
2693	NFAT-JUN-FOS DNA-protein complex	Human	None	None	P01100;P05412;Q13469	2353;3725;4773	MI:0114-x-ray crystallography	GO:0045893;GO:0003677;GO:0006955	positive regulation of DNA-templated transcription;DNA binding;immune response	11.02.03.04.01;16.03.01;36.25.16	transcription activation;DNA binding;immune response	9510247	NFAT and heterodimer Fos-Jun cooperatively bind a composite DNA site and synergistically activate the expression of many immune-response genes.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein c-Fos;Transcription factor Jun;Nuclear factor of activated T-cells, cytoplasmic 2	FOS;JUN;NFATC2	G0S7;None;NFAT1 NFATP
2694	ERG-JUN-FOS DNA-protein complex	Human	None	None	P01100;P05412;P11308	2353;3725;2078	MI:0096-pull down;MI:0114-x-ray crystallography;MI:0413-electrophoretic mobility shift assay	GO:2001141;GO:0006355;GO:0003677;GO:0005634	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;DNA binding;nucleus	11.02.03.04;16.03.01;70.10	transcriptional control;DNA binding;nucleus	11278640	The authors demonstrated that amino acids Arg(367) and Tyr(371) of the ETS domain, but not Asp374, play an important role in the recruitment of the Jun/Fos heterodimer by Erg. The authors propose that interdependent protein-protein and protein-DNA contacts regulate Erg-Jun/Fos-DNA complex assembly.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein c-Fos;Transcription factor Jun;Transcriptional regulator ERG	FOS;JUN;ERG	G0S7;None;None
2695	ETS2-FOS-JUN complex	Human	None	None	P01100;P05412;P15036	2353;3725;2114	MI:0096-pull down	GO:2001141;GO:0006355;GO:0003677;GO:0005634	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;DNA binding;nucleus	11.02.03.04;16.03.01;70.10	transcriptional control;DNA binding;nucleus	9334186	The results suggest that stromelysin-1 promoter DNA can enhance the ETS2/Fos/Jun interaction, perhaps by stabilizing protein contacts.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein c-Fos;Transcription factor Jun;Protein C-ets-2	FOS;JUN;ETS2	G0S7;None;
2699	ESR1-JUN-GRIP1 complex	Human	ER-alpha-GRIP1-c-Jun complex	None	P03372;P05412;Q9Y3R0	2099;3725;23426	MI:0096-pull down	GO:2001141;GO:0006355;GO:0023052	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;signaling	11.02.03.04;30.01	transcriptional control;cellular signalling	11477071	The authors showed that ERalpha , c-Jun, and the p160 coactivator GRIP1 can form a multiprotein complex in vitro and in intact cells and that the ERalpha - c-Jun interaction could be crucial for the stability of this complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Estrogen receptor;Transcription factor Jun;Glutamate receptor-interacting protein 1	ESR1;JUN;GRIP1	ESR NR3A1;None;None
2700	ESR1-JUN complex	Human	ER-alpha-c-Jun complex	None	P03372;P05412	2099;3725	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:2001141;GO:0006355;GO:0003677;GO:0023052	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;DNA binding;signaling	11.02.03.04;16.03.01;30.01	transcriptional control;DNA binding;cellular signalling	11477071	All experiments demonstrated that ER-alpha and c-Jun could interact in mammalian cells in a ligand-dependent manner.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Estrogen receptor;Transcription factor Jun	ESR1;JUN	ESR NR3A1;None
2704	Ectodermin-SMAD4 complex	Human	None	None	Q13485;Q9UPN9	4089;51592	MI:0007-anti tag coimmunoprecipitation	GO:0016567;GO:0007179;GO:0005634	protein ubiquitination;transforming growth factor beta receptor signaling pathway;nucleus	14.07.05;30.05.01.18.01;70.10	modification by ubiquitination, deubiquitination;TGF-beta-receptor signalling pathway;nucleus	15820681	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Mothers against decapentaplegic homolog 4;E3 ubiquitin-protein ligase TRIM33	SMAD4;TRIM33	DPC4 MADH4;KIAA1113 RFG7 TIF1G
2705	SMAD3-SMAD4-CTCF protein-DNA complex	Human	None	None	P49711;P84022;Q13485	10664;4088;4089	MI:0413-electrophoretic mobility shift assay	GO:2001141;GO:0006355;GO:0003677;GO:0007179;GO:0005634	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;DNA binding;transforming growth factor beta receptor signaling pathway;nucleus	11.02.03.04;16.03.01;30.05.01.18.01;70.10	transcriptional control;DNA binding;TGF-beta-receptor signalling pathway;nucleus	12099698	The authors demonstrated that TGF-beta increases APP gene transcription in NHAs (normal human astrocytes) through activation of the proximal APP promoter domain, (-488) base pairs (bp) relative to the transcription start site (+1). In the presence of TGF-beta stimulation, Smads 3 and 4 specifically associated with the CTCF-APBbeta complex, likely enhancing APP gene transcription.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transcriptional repressor CTCF;Mothers against decapentaplegic homolog 3;Mothers against decapentaplegic homolog 4	CTCF;SMAD3;SMAD4	None;MADH3;DPC4 MADH4
2706	SMAD3-SMAD4-SP1 complex	Human	None	None	P08047;P84022;Q13485	6667;4088;4089	MI:0019-coimmunoprecipitation;MI:0413-electrophoretic mobility shift assay	GO:2001141;GO:0006355;GO:0003677;GO:0007179;GO:0005634	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;DNA binding;transforming growth factor beta receptor signaling pathway;nucleus	11.02.03.04;16.03.01;30.05.01.18.01;70.10	transcriptional control;DNA binding;TGF-beta-receptor signalling pathway;nucleus	11432852	The authors demonstrated that Sp1 and Smad3/Smad4 are able to bind the endoglin promoter at positions -50/-29 forming a multiprotein complex, and suggest their cooperation in the transcriptional activity of endoglin.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transcription factor Sp1;Mothers against decapentaplegic homolog 3;Mothers against decapentaplegic homolog 4	SP1;SMAD3;SMAD4	TSFP1;MADH3;DPC4 MADH4
2707	SMAD3-SMAD4-FOXO3-FOXG1 complex	Human	None	epithelium	O43524;P55316;P84022;Q13485	2309;2290;4088;4089	MI:0007-anti tag coimmunoprecipitation	GO:2001141;GO:0006355;GO:0003677;GO:0007179;GO:0005634	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;DNA binding;transforming growth factor beta receptor signaling pathway;nucleus	11.02.03.04;16.03.01;30.05.01.18.01;70.10	transcriptional control;DNA binding;TGF-beta-receptor signalling pathway;nucleus	15084259	The results suggest that FoxG1 is a direct inhibitor of the FoxO-Smad transcriptional complex and a blocker of p21Cip1 induction by TGF-beta signals in neuroepithelial cells.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Forkhead box protein O3;Forkhead box protein G1;Mothers against decapentaplegic homolog 3;Mothers against decapentaplegic homolog 4	FOXO3;FOXG1;SMAD3;SMAD4	FKHRL1, FOXO3A;FKH2 FKHL1 FKHL2 FKHL3 FKHL4 FOXG1A FOXG1B FOXG1C;MADH3;DPC4 MADH4
2708	SMAD3-SMAD4-cJUN complex	Human	None	None	P05412;P84022;Q13485	3725;4088;4089	MI:0096-pull down	GO:2001141;GO:0006355;GO:0007179;GO:0005634	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;transforming growth factor beta receptor signaling pathway;nucleus	11.02.03.04;30.05.01.18.01;70.10	transcriptional control;TGF-beta-receptor signalling pathway;nucleus	10220381	On TGF-beta  treatment, Smad3 and Smad4 heteromerize and enter the nucleus, where they can associate with TGF-beta-responsive promoters by binding a discreet DNA sequence and/or AP-1 members bound to AP-1 sites on the same promoter.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transcription factor Jun;Mothers against decapentaplegic homolog 3;Mothers against decapentaplegic homolog 4	JUN;SMAD3;SMAD4	None;MADH3;DPC4 MADH4
2709	LRP1-MMP9-TIMP1 complex	Human	None	in vitro	P01033;P14780;Q07954	7076;4318;4035	MI:0047-far western blotting;MI:0411-enzyme linked immunosorbent assay	GO:0030234;GO:0050790;GO:0006898;GO:0030198	enzyme regulator activity;regulation of catalytic activity;receptor-mediated endocytosis;extracellular matrix organization	18.02.01;20.09.18.09.01.01;42.27.01	enzymatic activity regulation / enzyme regulator;receptor-mediated endocytosis;extracellular matrix	11279011	LRP is a functional receptor for MMP-9 and suggest a major role for LRP in modulating remodeling of the extracellular matrix by regulating extracellular proteinase activity. The MMP-9/TIMP-1 complex binds to LRP with high affinity.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Metalloproteinase inhibitor 1;Matrix metalloproteinase-9;Prolow-density lipoprotein receptor-related protein 1	TIMP1;MMP9;LRP1	CLGI TIMP;CLG4B;A2MR APR
2711	Abeta(40/42) oligomer complex	Human	Amyloid beta protein (40/42) oligomer complex	in vitro	P05067-PRO_0000000092;P05067-PRO_0000000093	351;351	MI:0019-coimmunoprecipitation;MI:0040-electron microscopy	GO:1900272;GO:0048169;GO:0106003	negative regulation of long-term synaptic potentiation;regulation of long-term neuronal synaptic plasticity;amyloid-beta complex	None	None	15834427	Size fractionation showed that Abeta oligomers, not monomers or fibrils, were responsible for inhibiting long-term potentiation (LTP), and an Abeta antibody again prevented such inhibition.	The ability of exogenous and endogenous antibodies to rapidly neutralize soluble Abeta oligomers that disrupt synaptic plasticity in vivo suggests that treatment with such antibodies might show reversible cognitive deficits in early Alzheimer disease.	a mix of Abeta (1-40) and Abeta (1-42)  was used	Homo sapiens (Human);Homo sapiens (Human)	Amyloid-beta precursor protein;Amyloid-beta precursor protein	APP;APP	A4 AD1;A4 AD1
2714	Ubiquitin E3 ligase (CHEK1, CUL1)	Human	None	None	O14757;Q13616	1111;8454	MI:0019-coimmunoprecipitation	GO:0016567;GO:0043161;GO:0006511;GO:0006974;GO:0005634	protein ubiquitination;proteasome-mediated ubiquitin-dependent protein catabolic process;ubiquitin-dependent protein catabolic process;cellular response to DNA damage stimulus;nucleus	14.07.05;14.13.01.01;32.01.09;70.10	modification by ubiquitination, deubiquitination;proteasomal degradation (ubiquitin/proteasomal pathway);DNA damage response;nucleus	16137618	Ubiquitin E3 ligases covalently attach ubiquitin to a lysine residue on a target protein. Polyubiquitination marks proteins for degradation by the proteasome. The Chk1 kinase is a major effector of S phase checkpoint signaling during the cellular response to genotoxic stress. Replicative stress induces the polyubiquitination and degradation of Chk1 in human cells.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein kinase Chk1;Cullin-1	CHEK1;CUL1	CHK1;None
2715	Ubiquitin E3 ligase (CUL1/2/3, CSN1/8, RBX1, SKP1/2)	Human	None	HeLa cells	P62877;P63208;Q13098;Q13309;Q13616;Q13617;Q13618;Q99627	9978;6500;2873;6502;8454;8453;8452;10920	MI:0047-far western blotting	GO:0006511;GO:0031461	ubiquitin-dependent protein catabolic process;cullin-RING ubiquitin ligase complex	14.13.01.01	proteasomal degradation (ubiquitin/proteasomal pathway)	11337588	Ubiquitin E3 ligases covalently attach ubiquitin to a lysine residue on a target protein. Polyubiquitination marks proteins for degradation by the proteasome. SCF ubiquitin ligases consist of at least four subunits: CUL1 and HRT1 (=ROC1, RBX1), which harbor a core ubiquitin ligase activity; a variable F-box protein that serves as a substrate receptor; and SKP1, which links the two modules together. Because CSN binds all cullins, it might be a global signal integrator that radiates its output onto various associated ubiquitin ligases to modulate their activity.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase RBX1;S-phase kinase-associated protein 1;COP9 signalosome complex subunit 1;S-phase kinase-associated protein 2;Cullin-1;Cullin-2;Cullin-3;COP9 signalosome complex subunit 8	RBX1;SKP1;GPS1;SKP2;CUL1;CUL2;CUL3;COPS8	RNF75 ROC1;EMC19 OCP2 SKP1A TCEB1L;COPS1, CSN1;FBXL1;None;None;KIAA0617;CSN8
2716	Elongator core complex	Human	None	None	O95163;Q6IA86;Q9H9T3	8518;55250;55140	MI:0029-cosedimentation through density gradient	GO:0006354;GO:0005634	DNA-templated transcription elongation;nucleus	11.02.03.01.04;70.10	transcription elongation;nucleus	11714725	The core-Elongator complex does not have histone acetyltransferase activity despite containing the catalytic Elp3 subunit.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Elongator complex protein 1;Elongator complex protein 2;Elongator complex protein 3	ELP1;ELP2;ELP3	IKAP IKBKAP;STATIP1;None
2717	DDX58-TRIM25 complex	Human	RIG-I-TRIM25 complex; Ubiquitin E3 ligase (TRIM25, DDX58)	HEK293T cells	O95786;Q14258	23586;7706	MI:0096-pull down	GO:0035556;GO:0005737;GO:0002221;GO:0039529;GO:0045087;GO:0032481;GO:0051607;GO:0016567;GO:0019048	intracellular signal transduction;cytoplasm;pattern recognition receptor signaling pathway;RIG-I signaling pathway;innate immune response;positive regulation of type I interferon production;defense response to virus;protein ubiquitination;modulation by virus of host process	30.01;70.03;36.25.16.01;14.07.05	cellular signalling;cytoplasm;innate immune response (invertebrates and vertebrates);modification by ubiquitination, deubiquitination	17392790	TRIM25 E3 ubiquitin ligase induces the Lys 63-linked ubiquitination of RIG-I, which is crucial for the cytosolic RIG-I signalling pathway to elicit host antiviral innate immunity (PMID:17392790). Viruses have evolved several strategies to evade the immune system of the host. Influenza A virus NS1 targets the ubiquitin ligase TRIM25 and prevents RIG-I-TRIM25 complex formation to evade recognition by the host viral RNA sensor RIG-I (PMID:19454348).	None	None	Homo sapiens (Human);Homo sapiens (Human)	Antiviral innate immune response receptor RIG-I;E3 ubiquitin/ISG15 ligase TRIM25	DDX58;TRIM25	None;EFP RNF147 ZNF147
2718	CDC20-MAD2 complex	Human	None	None	Q12834;Q13257	991;4085	MI:0114-x-ray crystallography	GO:0007094;GO:0031145;GO:0051726	mitotic spindle assembly checkpoint signaling;anaphase-promoting complex-dependent catabolic process;regulation of cell cycle	10.03.01	mitotic cell cycle and cell cycle control	10700282	The checkpoint protein Mad2 inhibits the activity of the anaphase promoting complex by sequestering Cdc20 until all chromosomes are aligned at the metaphase plate.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cell division cycle protein 20 homolog;Mitotic spindle assembly checkpoint protein MAD2A	CDC20;MAD2L1	None;MAD2
2719	Casein kinase II-HMG1 complex	Human	FCP1-specific kinase complex	HeLa nuclear extract	P09429;P19784;P67870;P68400	3146;1459;1460;1457	MI:0029-cosedimentation through density gradient	GO:0006468;GO:0032785;GO:0030234	protein phosphorylation;negative regulation of DNA-templated transcription, elongation;enzyme regulator activity	14.07.03;18.02.01	modification by phosphorylation, dephosphorylation, autophosphorylation;enzymatic activity regulation / enzyme regulator	12591939	CK2 is comprised of the subunits CK2alpha , CK2alpha ', and CK2beta , and the differences in FCP1 kinase activity among the elution fractions reflect a dose-dependent effect related to the amount of CK2 present but do not depend on the presence of HMG1.Phosphorylation of FCP1 by CK2 inhibits the transcription elongation activity of FCP1.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	High mobility group protein B1;Casein kinase II subunit alpha';Casein kinase II subunit beta;Casein kinase II subunit alpha	HMGB1;CSNK2A2;CSNK2B;CSNK2A1	HMG1;CK2A2;CK2N G5A;CK2A1
2720	Casein kinase II (beta-dimer, alpha, alpha')	Human	CK2 complex; FCP1-specific kinase complex	None	P19784;P67870;P68400	1459;1460;1457	MI:0029-cosedimentation through density gradient	GO:0006468;GO:0030234;GO:0032785	protein phosphorylation;enzyme regulator activity;negative regulation of DNA-templated transcription, elongation	14.07.03;18.02.01	modification by phosphorylation, dephosphorylation, autophosphorylation;enzymatic activity regulation / enzyme regulator	12591939	CK2 phosphorylates FCP1 and RAP74. Phosphorylation of FCP1 by CK2 inhibits the transcription elongation activity of FCP1.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Casein kinase II subunit alpha';Casein kinase II subunit beta;Casein kinase II subunit alpha	CSNK2A2;CSNK2B;CSNK2A1	CK2A2;CK2N G5A;CK2A1
2721	HCF-1 complex	Human	HCF-1-associated protein complex	None	O15047;O15294;O75182;O75446;P07900;P08047;P11021;P11142;P34932;P51610;P61964;Q09028;Q13547;Q16576;Q92769;Q96ST3;Q9H7L9;Q9UBL3	9739;8473;23309;8819;3320;6667;3309;3312;3308;3054;11091;5928;3065;5931;3066;25942;64426;9070	MI:0007-anti tag coimmunoprecipitation	GO:0006265;GO:0000910;GO:0000917;GO:2001141;GO:0006355;GO:0000902;GO:0016049;GO:0051276;GO:0005634;GO:0016575;GO:0016571	DNA topological change;cytokinesis;division septum assembly;regulation of RNA biosynthetic process;regulation of DNA-templated transcription;cell morphogenesis;cell growth;chromosome organization;nucleus;histone deacetylation;histone methylation	10.01.09.05;10.03.03;11.02.03.04;40.01;42.10.03;70.10	DNA conformation modification (e.g. chromatin);cytokinesis (cell division) /septum formation and hydrolysis;transcriptional control;cell growth / morphogenesis;organization of chromosome structure;nucleus	12670868	HCF-1 can regulate transcription, both positively and negatively, through selective modulation of chromatin structure.	None	Since the authors did not specify HSP90A, we used HSP90AA1.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone-lysine N-methyltransferase SETD1A;UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit;Paired amphipathic helix protein Sin3b;Histone deacetylase complex subunit SAP30;Heat shock protein HSP 90-alpha;Transcription factor Sp1;Endoplasmic reticulum chaperone BiP;Heat shock cognate 71 kDa protein;Heat shock 70 kDa protein 4;Host cell factor 1;WD repeat-containing protein 5;Histone-binding protein RBBP4;Histone deacetylase 1;Histone-binding protein RBBP7;Histone deacetylase 2;Paired amphipathic helix protein Sin3a;Sin3 histone deacetylase corepressor complex component SDS3;Set1/Ash2 histone methyltransferase complex subunit ASH2	SETD1A;OGT;SIN3B;SAP30;HSP90AA1;SP1;HSPA5;HSPA8;HSPA4;HCFC1;WDR5;RBBP4;HDAC1;RBBP7;HDAC2;SIN3A;SUDS3;ASH2L	KIAA0339 KMT2F SET1 SET1A;None;KIAA0700;None;HSP90A HSPC1 HSPCA;TSFP1;GRP78;HSC70 HSP73 HSPA10;APG2;HCF1, HFC1;BIG3;RBAP48;RPD3L1;RBAP46;None;None;SAP45 SDS3;ASH2L1
2723	ATM-NBN complex	Human	ATM-NBS1 complex	None	O60934;Q13315	4683;472	MI:0006-anti bait coimmunoprecipitation;MI:0007-anti tag coimmunoprecipitation;MI:0096-pull down	GO:0000075;GO:0006468;GO:0046777;GO:0006974;GO:0009314;GO:0005634	cell cycle checkpoint signaling;protein phosphorylation;protein autophosphorylation;cellular response to DNA damage stimulus;response to radiation;nucleus	10.03.01.03;14.07.03;32.01.09;32.01.13;70.10	cell cycle checkpoints (checkpoints of morphogenesis, DNA-damage,-replication, mitotic phase and spindle);modification by phosphorylation, dephosphorylation, autophosphorylation;DNA damage response;electromagnetic waves stress response (e.g. UV, X-ray);nucleus	10839544	NBS1 (NBN) was co-immunoprecipitated by the ATM antibody from untreated cells and in increased quantities from cells treated with ionizing radiation. The results indicate that phosphorylation of Ser 278 and Ser 343 in NBS1 contributes to both cellular resistance to ionizing radiation and formation of foci that contain NBS1 in response to ionizing radiation.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Nibrin;Serine-protein kinase ATM	NBN;ATM	NBS NBS1 P95;None
2724	Ubiquitin E3 ligase (NFKBIA, BTRC, CUL1, SKP1A)	Human	None	None	P25963;P63208;Q13616;Q9Y297	4792;6500;8454;8945	MI:0007-anti tag coimmunoprecipitation	GO:0016567;GO:0043161;GO:0006511	protein ubiquitination;proteasome-mediated ubiquitin-dependent protein catabolic process;ubiquitin-dependent protein catabolic process	14.07.05;14.13.01.01	modification by ubiquitination, deubiquitination;proteasomal degradation (ubiquitin/proteasomal pathway)	10644755	Ubiquitin E3 ligases covalently attach ubiquitin to a lysine residue on a target protein. Polyubiquitination marks proteins for degradation by the proteasome. Ubiquitination-dependent destruction of NF-kappa-B inhibitor alpha is mediated by ubiquitin E3 ligases containing heterdimers and homodimers of beta-TrCP1 (BTRC) and beta-TrCP2 (FBXW11).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	NF-kappa-B inhibitor alpha;S-phase kinase-associated protein 1;Cullin-1;F-box/WD repeat-containing protein 1A	NFKBIA;SKP1;CUL1;BTRC	IKBA MAD3 NFKBI;EMC19 OCP2 SKP1A TCEB1L;None;BTRCP FBW1A FBXW1A
2725	Ubiquitin E3 ligase (NFKBIA, FBXW11, CUL1, SKP1A)	Human	None	None	P25963;P63208;Q13616;Q9UKB1	4792;6500;8454;23291	MI:0007-anti tag coimmunoprecipitation	GO:0016567;GO:0043161;GO:0006511;GO:0005737;GO:0043122	protein ubiquitination;proteasome-mediated ubiquitin-dependent protein catabolic process;ubiquitin-dependent protein catabolic process;cytoplasm;regulation of I-kappaB kinase/NF-kappaB signaling	14.07.05;14.13.01.01;70.03	modification by ubiquitination, deubiquitination;proteasomal degradation (ubiquitin/proteasomal pathway);cytoplasm	10644755	Ubiquitin E3 ligases covalently attach ubiquitin to a lysine residue on a target protein. Polyubiquitination marks proteins for degradation by the proteasome. Ubiquitination-dependent destruction of NF-kappa-B inhibitor alpha is mediated by ubiquitin E3 ligases containing heterdimers and homodimers of beta-TrCP1 (BTRC) and beta-TrCP2 (FBXW11).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	NF-kappa-B inhibitor alpha;S-phase kinase-associated protein 1;Cullin-1;F-box/WD repeat-containing protein 11	NFKBIA;SKP1;CUL1;FBXW11	IKBA MAD3 NFKBI;EMC19 OCP2 SKP1A TCEB1L;None;BTRCP2 FBW1B FBXW1B KIAA0696
2726	PXN-ITGB5-PTK2 complex	Human	None	None	P18084;P49023;Q05397	3693;5829;5747	MI:0019-coimmunoprecipitation	GO:0007229	integrin-mediated signaling pathway	30.05.02.26	integrin receptor signalling pathway	11278329	The changes in the expression of PAR1 in a cell affect its invasive capabilities. These changes come about through the specific recruitment of the alpha(v)-beta 5 integrin, through cytoskeletal reorganization, and through distinct signaling at FACs.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-5;Paxillin;Focal adhesion kinase 1	ITGB5;PXN;PTK2	None;None;FAK, FAK1
2727	SRC-3 complex	Human	None	None	O14920;O15111;P10155;Q15596;Q92793;Q9Y6K9;Q9Y6Q9	3551;1147;6738;10499;1387;8517;8202	MI:0006-anti bait coimmunoprecipitation;MI:0071-molecular sieving;MI:0226-ion exchange chromatography	GO:0045893;GO:0006473;GO:0006476;GO:0007249;GO:0023052;GO:0006954;GO:0005634	positive regulation of DNA-templated transcription;protein acetylation;protein deacetylation;I-kappaB kinase/NF-kappaB signaling;signaling;inflammatory response;nucleus	11.02.03.04.01;14.07.04;30.01.05.01.04;30.01;36.25.16.07;70.10	transcription activation;modification by acetylation, deacetylation;NIK-I-kappaB/NF-kappaB cascade;cellular signalling;inflammatory response;nucleus	11971985	SRC-3 enhances NF-kappaB-mediated gene expression in concert with IKK.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Inhibitor of nuclear factor kappa-B kinase subunit beta;Inhibitor of nuclear factor kappa-B kinase subunit alpha;RNA-binding protein RO60;Nuclear receptor coactivator 2;CREB-binding protein;NF-kappa-B essential modulator;Nuclear receptor coactivator 3	IKBKB;CHUK;RO60;NCOA2;CREBBP;IKBKG;NCOA3	IKKB;IKKA TCF16;SSA2 TROVE2;BHLHE75 SRC2 TIF2;CBP;FIP3, NEMO;AIB1 BHLHE42 RAC3 TRAM1
2728	SRC-1 complex	Human	None	None	P10155;Q15596;Q15788;Q92793	6738;10499;8648;1387	MI:0006-anti bait coimmunoprecipitation;MI:0071-molecular sieving;MI:0226-ion exchange chromatography	GO:0007249;GO:0023052;GO:0005634	I-kappaB kinase/NF-kappaB signaling;signaling;nucleus	30.01.05.01.04;30.01;70.10	NIK-I-kappaB/NF-kappaB cascade;cellular signalling;nucleus	11971985	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	RNA-binding protein RO60;Nuclear receptor coactivator 2;Nuclear receptor coactivator 1;CREB-binding protein	RO60;NCOA2;NCOA1;CREBBP	SSA2 TROVE2;BHLHE75 SRC2 TIF2;BHLHE74 SRC1;CBP
2730	Set1B complex	Human	None	kidney	P61964;Q15291;Q6UXN9;Q9P0U4;Q9UBL3;Q9UPS6	11091;5929;80335;30827;9070;23067	MI:0007-anti tag coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0006265;GO:0006349;GO:0006479;GO:0003677;GO:0051276;GO:0005634	DNA topological change;regulation of gene expression by genomic imprinting;protein methylation;DNA binding;chromosome organization;nucleus	10.01.09.05;10.01.09.07;14.07.09;16.03.01;42.10.03;70.10	DNA conformation modification (e.g. chromatin);DNA imprinting and other epigenetic effects;posttranslational modification of amino acids (e.g. hydroxylation, methylation);DNA binding;organization of chromosome structure;nucleus	17355966	The SET1B complex is a methyltransferase that produces trimethylated histone H3 at Lysine 4.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	WD repeat-containing protein 5;Retinoblastoma-binding protein 5;WD repeat-containing protein 82;CXXC-type zinc finger protein 1;Set1/Ash2 histone methyltransferase complex subunit ASH2;Histone-lysine N-methyltransferase SETD1B	WDR5;RBBP5;WDR82;CXXC1;ASH2L;SETD1B	BIG3;RBQ3;SWD2 TMEM113 WDR82A;CFP1 CGBP PCCX1 PHF18;ASH2L1;KIAA1076 KMT2G SET1B
2731	Set1A complex	Human	SET1-CFP1 complex	kidney	O15047;P61964;Q15291;Q6UXN9;Q9P0U4;Q9UBL3	9739;11091;5929;80335;30827;9070	MI:0007-anti tag coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0006265;GO:0003677;GO:0051276;GO:0005634;GO:0051568	DNA topological change;DNA binding;chromosome organization;nucleus;histone H3-K4 methylation	10.01.09.05;16.03.01;42.10.03;70.10	DNA conformation modification (e.g. chromatin);DNA binding;organization of chromosome structure;nucleus	17355966	The SET1A complex is a methyltransferase that produces mono-di- and trimethylated histone H3 at Lysine 4.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone-lysine N-methyltransferase SETD1A;WD repeat-containing protein 5;Retinoblastoma-binding protein 5;WD repeat-containing protein 82;CXXC-type zinc finger protein 1;Set1/Ash2 histone methyltransferase complex subunit ASH2	SETD1A;WDR5;RBBP5;WDR82;CXXC1;ASH2L	KIAA0339 KMT2F SET1 SET1A;BIG3;RBQ3;SWD2 TMEM113 WDR82A;CFP1 CGBP PCCX1 PHF18;ASH2L1
2734	APH1A-PSEN1-NCSTN complex	Human	None	brain	P49768;Q92542;Q96BI3	5663;23385;51107	MI:0007-anti tag coimmunoprecipitation;MI:0096-pull down	GO:0043161;GO:0006511;GO:0007219;GO:0005886	proteasome-mediated ubiquitin-dependent protein catabolic process;ubiquitin-dependent protein catabolic process;Notch signaling pathway;plasma membrane	14.13.01.01;30.05.02.14;70.02	proteasomal degradation (ubiquitin/proteasomal pathway);Notch-receptor signalling pathway;eukaryotic plasma membrane / membrane attached	12297508	Presenilin, nicastrin and mAPH1a are essential components of the gamma-secretase complex that is required for the intramembrane proteolysis of membrane proteins including the amyloid-beta precursor protein (APP) and Notch. The authors use the splice variant mAPH-1a-L for  experiments.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Presenilin-1;Nicastrin;Gamma-secretase subunit APH-1A	PSEN1;NCSTN;APH1A	AD3 PS1 PSNL1;KIAA0253;PSF
2735	APH1A-PSEN2-NCSTN complex	Human	None	None	P49810;Q92542;Q96BI3	5664;23385;51107	MI:0007-anti tag coimmunoprecipitation	GO:0043161;GO:0006511;GO:0007219	proteasome-mediated ubiquitin-dependent protein catabolic process;ubiquitin-dependent protein catabolic process;Notch signaling pathway	14.13.01.01;30.05.02.14	proteasomal degradation (ubiquitin/proteasomal pathway);Notch-receptor signalling pathway	12297508	Presenilin, nicastrin and mAPH1a are essential components of the gamma-secretase complex that is required for the intramembrane proteolysis of membrane proteins including the amyloid-beta precursor protein (APP) and Notch. The authors use the splice variant mAPH-1a-L for  experiments. In an additional pull down experiment the authors show the interaction of APH1B with presenilin 2.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Presenilin-2;Nicastrin;Gamma-secretase subunit APH-1A	PSEN2;NCSTN;APH1A	AD4 PS2 PSNL2 STM2;KIAA0253;PSF
2736	TROY-NGR-LINGO1 complex	Human	TROY-NgR1-LINGO1 complex	COS-7 cells	Q96FE5;Q9BZR6;Q9NS68	84894;65078;55504	MI:0019-coimmunoprecipitation	GO:0022008;GO:0048699;GO:0031175	neurogenesis;generation of neurons;neuron projection development	41.05.13	neurogenesis	15694322	The authors additionally analyzed interactions between TAJ-NgR1 and TAJ-LINGO-1. The authors show that TAJ/TROY (an orphan receptor in the TNF family), broadly expressed in postnatal and adult neurons, binds to NgR1 and can replace p75 in the p75/NgR1/LINGO-1 complex to activate RhoA in the presence of myelin inhibitors.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1;Reticulon-4 receptor;Tumor necrosis factor receptor superfamily member 19	LINGO1;RTN4R;TNFRSF19	LERN1 LRRN6A;NOGOR;TAJ TROY
2738	BLM complex II	Human	BLM-CII complex	HeLa nuclear extract	P15927;P27694;P35244;P54132;Q13472;Q9H9A7	6118;6117;6119;641;7156;80010	MI:0006-anti bait coimmunoprecipitation	GO:0051276;GO:0006281;GO:0006974;GO:0005634	chromosome organization;DNA repair;cellular response to DNA damage stimulus;nucleus	42.10.03;10.01.05.01;32.01.09;70.10	organization of chromosome structure;DNA repair;DNA damage response;nucleus	12724401	None	BLM complex II is involved in Bloom syndrome (BS).	Another subunit of the complex was found in the analysis, which has not been further characterized: BLAPp100.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Replication protein A 32 kDa subunit;Replication protein A 70 kDa DNA-binding subunit;Replication protein A 14 kDa subunit;RecQ-like DNA helicase BLM;DNA topoisomerase 3-alpha;RecQ-mediated genome instability protein 1	RPA2;RPA1;RPA3;BLM;TOP3A;RMI1	REPA2 RPA32 RPA34;REPA1 RPA70;REPA3 RPA14;RECQ2 RECQL3;TOP3;C9orf76
2739	FA complex (Fanconi anemia complex)	Human	None	None	O15287;O15360;P27694;P54132;Q00597;Q13472;Q8NB91;Q9H9A7;Q9HB96;Q9NPI8;Q9NW38	2189;2175;6117;641;2176;7156;2187;80010;2178;2188;55120	MI:0006-anti bait coimmunoprecipitation	GO:0016567;GO:0006974;GO:0005634	protein ubiquitination;cellular response to DNA damage stimulus;nucleus	14.07.05;32.01.09;70.10	modification by ubiquitination, deubiquitination;DNA damage response;nucleus	12724401	The FA complex contains several other proteins of unknown function, called FAAPs.	FA complex is involved in Fanconi anemia (FA) disease.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Fanconi anemia group G protein;Fanconi anemia group A protein;Replication protein A 70 kDa DNA-binding subunit;RecQ-like DNA helicase BLM;Fanconi anemia group C protein;DNA topoisomerase 3-alpha;Fanconi anemia group B protein;RecQ-mediated genome instability protein 1;Fanconi anemia group E protein;Fanconi anemia group F protein;E3 ubiquitin-protein ligase FANCL	FANCG;FANCA;RPA1;BLM;FANCC;TOP3A;FANCB;RMI1;FANCE;FANCF;FANCL	XRCC9;FAA FACA FANCH;REPA1 RPA70;RECQ2 RECQL3;FAC FACC;TOP3;None;C9orf76;FACE;None;PHF9
2743	TRAF6-MALT1 complex	Human	None	lymphocyte	Q9UDY8-1;Q9Y4K3	10892;7189	MI:0019-coimmunoprecipitation	GO:0043085;GO:0008047	positive regulation of catalytic activity;enzyme activator activity	18.02.01.01	enzyme activator	15125833	The CARD domain protein BCL10 and paracaspase MALT1 are essential for the activation of IkappaB kinase (IKK) and NF-kappaB in response to T cell receptor (TCR) stimulation. TRAF6 ubiquitin ligase and TAK1 protein kinase mediate IKK activation by BCL10 and MALT1. MALT1 binds to TRAF6 through the C-terminal binding sites and induces the oligomerization of TRAF6 to activate IKK.	None	MALT1 (824 aa) = splice variant/isoform.	Homo sapiens (Human);Homo sapiens (Human)	Isoform 1 of Mucosa-associated lymphoid tissue lymphoma translocation protein 1;TNF receptor-associated factor 6	MALT1;TRAF6	MLT;RNF85
2744	TRAF2-MALT1 complex	Human	None	lymphocyte	Q12933;Q9UDY8;Q9UDY8-1	7186;10892;10892	MI:0019-coimmunoprecipitation	GO:0043085;GO:0008047	positive regulation of catalytic activity;enzyme activator activity	18.02.01.01	enzyme activator	15125833	None	None	MALT1 (824 aa) = splice variant/isoform.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	TNF receptor-associated factor 2;Mucosa-associated lymphoid tissue lymphoma translocation protein 1;Isoform 1 of Mucosa-associated lymphoid tissue lymphoma translocation protein 1	TRAF2;MALT1;MALT1	TRAP3;MLT;MLT
2745	Ubiquitin ligase complex (BCL10, CARD11, MALT1, TRAF6)	Human	None	HEK293 cells; HeLa cells; Jurkat cell extract	O95999;Q9BXL7;Q9UDY8-1;Q9Y4K3	8915;84433;10892;7189	MI:0019-coimmunoprecipitation	GO:0016567;GO:0043085;GO:0008047;GO:0006511	protein ubiquitination;positive regulation of catalytic activity;enzyme activator activity;ubiquitin-dependent protein catabolic process	14.07.05;18.02.01.01;14.13.01.01	modification by ubiquitination, deubiquitination;enzyme activator;proteasomal degradation (ubiquitin/proteasomal pathway)	15125833	A small fraction of BCL10 and MALT1 proteins form high molecular weight oligomers. Only these oligomeric forms of BCL10 and MALT1 can activate IkappaB kinase in vitro. The MALT1 oligomers bind to TRAF6, induce TRAF6 oligomerization, and activate the ligase activity of TRAF6 to polyubiquitinate NEMO. These results reveal an oligomerization --> ubiquitination --> phosphorylation cascade that culminates in NF-kappaB activation in T lymphocytes.	None	MALT1 (824 aa) = splice variant/isoform; BCL10 (233 aa) = splice variant/isoform.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	B-cell lymphoma/leukemia 10;Caspase recruitment domain-containing protein 11;Isoform 1 of Mucosa-associated lymphoid tissue lymphoma translocation protein 1;TNF receptor-associated factor 6	BCL10;CARD11;MALT1;TRAF6	CIPER, CLAP;CARMA1;MLT;RNF85
2749	SETDB1-containing HMTase complex	Human	ESET-SETDB1 complex	None	Q15047;Q6VMQ6	9869;55729	MI:0006-anti bait coimmunoprecipitation;MI:0071-molecular sieving;MI:0226-ion exchange chromatography	GO:0006265;GO:0045892;GO:0032774;GO:0006479;GO:0051276;GO:0005634	DNA topological change;negative regulation of DNA-templated transcription;RNA biosynthetic process;protein methylation;chromosome organization;nucleus	10.01.09.05;11.02.03.04.03;11.02;14.07.09;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription repression;RNA synthesis;posttranslational modification of amino acids (e.g. hydroxylation, methylation);organization of chromosome structure;nucleus	14536086	ATF7IP stimulates the HMTase activity of ESET (SETDB1) through facilitating the ESET-dependent conversion of dimethyl H3-K9 to the trimethyl state.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Histone-lysine N-methyltransferase SETDB1;Activating transcription factor 7-interacting protein 1	SETDB1;ATF7IP	ESET KIAA0067 KMT1E;MCAF MCAF1
2752	CARMA1-BCL10-MALT1 complex	Human	None	None	O95999;Q9BXL7;Q9UDY8	8915;84433;10892	MI:0019-coimmunoprecipitation	GO:0007249;GO:0005886	I-kappaB kinase/NF-kappaB signaling;plasma membrane	30.01.05.01.04;70.02	NIK-I-kappaB/NF-kappaB cascade;eukaryotic plasma membrane / membrane attached	17478723	The multiprotein complex consisting of the membrane-associated adapter protein CARMA1, the caspase-like protein MALT1, and the adapter protein BCL-10 is critical for TCR-dependent activation of the I{kappa}B kinase complex and subsequent NF-{kappa}B nuclear translocation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	B-cell lymphoma/leukemia 10;Caspase recruitment domain-containing protein 11;Mucosa-associated lymphoid tissue lymphoma translocation protein 1	BCL10;CARD11;MALT1	CIPER, CLAP;CARMA1;MLT
2753	FYB-CARMA1-BCL-10-MALT1 complex	Human	None	None	O15117;O95999;Q9BXL7;Q9UDY8	2533;8915;84433;10892	MI:0019-coimmunoprecipitation	GO:0007249;GO:0005886	I-kappaB kinase/NF-kappaB signaling;plasma membrane	30.01.05.01.04;70.02	NIK-I-kappaB/NF-kappaB cascade;eukaryotic plasma membrane / membrane attached	17478723	FYB (ADAP) was found to be an integral part of the multiprotein complex consisting of the membrane-associated adapter protein CARMA1, the caspase-like protein MALT1, and the adapter protein BCL-10, which is critical for TCR-dependent activation of the I{kappa}B kinase complex and subsequent NF-{kappa}B nuclear translocation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	FYN-binding protein 1;B-cell lymphoma/leukemia 10;Caspase recruitment domain-containing protein 11;Mucosa-associated lymphoid tissue lymphoma translocation protein 1	FYB1;BCL10;CARD11;MALT1	FYB SLAP130;CIPER, CLAP;CARMA1;MLT
2754	JUND-FOSB-SMAD3-SMAD4 complex	Human	TRE binding complex	None	P17535;P53539;P84022;Q13485	3727;2354;4088;4089	MI:0412-electrophoretic mobility supershift assay	GO:2001141;GO:0006355;GO:0007167;GO:0006915;GO:0005634	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;enzyme-linked receptor protein signaling pathway;apoptotic process;nucleus	11.02.03.04;30.05.01;40.10.02;70.10	transcriptional control;receptor enzyme mediated signalling;apoptosis (type I programmed cell death);nucleus	10942775	The authors found that only JunD and FosB, but not the other components of the AP-1 complex, are markedly induced during TGF-beta 1-dependent apoptosis. FosB enhanced Smad3\u00b7Smad4-dependent transcription, and its dominant-negative form blocked TGF-beta 1-dependent apoptosis but not growth inhibition. These results suggest that JunD\u00b7FosB activates transcription of a putative target gene for TGF-beta 1, which is responsible for apoptosis.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transcription factor JunD;Protein FosB;Mothers against decapentaplegic homolog 3;Mothers against decapentaplegic homolog 4	JUND;FOSB;SMAD3;SMAD4	None;G0S3;MADH3;DPC4 MADH4
2755	17S U2 snRNP	Human	None	None	O15042;O43143;O75533;O75937;O75940;P08579;P09661;P10809;P14678;P26368;P62304;P62306;P62308;P62314;P62316;P62318;Q01081;Q07955;Q12874;Q12931;Q13435;Q15393;Q15427;Q15428;Q15459;Q7L014;Q7RTV0;Q8IWX8;Q96I25;Q9BWJ5;Q9P0W2;Q9UHX1;Q9Y3B4	23350;1665;23451;22826;10285;6629;6627;3329;6628;11338;6635;6636;6637;6632;6633;6634;7307;6426;10946;10131;10992;23450;10262;8175;10291;9879;84844;10523;84991;83443;10362;22827;51639	MI:0019-coimmunoprecipitation	GO:0008380;GO:0005634	RNA splicing;nucleus	11.04.03.01;70.10	splicing;nucleus	12234937	Spliceosome assembly is initiated by the interaction of the U1 snRNP with the 5' splice site, forming the E complex. The latter also contains the 17S U2 snRNP, which at this stage associates via a non-base pairing interaction. In a subsequent ATP-dependent step, the U2 snRNA base pairs with the branch site of the pre-mRNA leading to stable association of the U2 snRNP and formation of the so-called A complex or prespliceosome.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	U2 snRNP-associated SURP motif-containing protein;ATP-dependent RNA helicase DHX15;Splicing factor 3B subunit 1;DnaJ homolog subfamily C member 8;Survival of motor neuron-related-splicing factor 30;U2 small nuclear ribonucleoprotein B'';U2 small nuclear ribonucleoprotein A';60 kDa heat shock protein, mitochondrial;Small nuclear ribonucleoprotein-associated proteins B and B';Splicing factor U2AF 65 kDa subunit;Small nuclear ribonucleoprotein E;Small nuclear ribonucleoprotein F;Small nuclear ribonucleoprotein G;Small nuclear ribonucleoprotein Sm D1;Small nuclear ribonucleoprotein Sm D2;Small nuclear ribonucleoprotein Sm D3;Splicing factor U2AF 35 kDa subunit;Serine/arginine-rich splicing factor 1;Splicing factor 3A subunit 3;Heat shock protein 75 kDa, mitochondrial;Splicing factor 3B subunit 2;Splicing factor 3B subunit 3;Splicing factor 3B subunit 4;Splicing factor 3A subunit 2;Splicing factor 3A subunit 1;Probable ATP-dependent RNA helicase DDX46;PHD finger-like domain-containing protein 5A;Calcium homeostasis endoplasmic reticulum protein;Splicing factor 45;Splicing factor 3B subunit 5;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related;Poly(U)-binding-splicing factor PUF60;Splicing factor 3B subunit 6	U2SURP;DHX15;SF3B1;DNAJC8;SMNDC1;SNRPB2;SNRPA1;HSPD1;SNRPB;U2AF2;SNRPE;SNRPF;SNRPG;SNRPD1;SNRPD2;SNRPD3;U2AF1;SRSF1;SF3A3;TRAP1;SF3B2;SF3B3;SF3B4;SF3A2;SF3A1;DDX46;PHF5A;CHERP;RBM17;SF3B5;HMG20B;PUF60;SF3B6	KIAA0332 SR140;DBP1 DDX15;SAP155;SPF31;SMNR SPF30;None;None;HSP60;COD SNRPB1;U2AF65;None;PBSCF;PBSCG;None;SNRPD1;None;U2AF35 U2AFBP;ASF SF2 SF2P33 SFRS1;SAP61;HSP75;SAP145;KIAA0017 SAP130;SAP49;SAP62;SAP114;KIAA0801;None;DAN26 SCAF6;SPF45;SF3B10;BRAF35 HMGX2 HMGXB2 SMARCE1R;FIR ROBPI SIAHBP1;SAP14 SF3B14 SF3B14A
2756	Ubiquitin ligase (UBE2N, UBE2V2)	Human	TRIKA1; Ubiquitin ligase (UBE2N, MMS2)	HEK293 cells	P61088;Q15819	7334;7336	MI:0019-coimmunoprecipitation	GO:0016567;GO:0019209;GO:0023052;GO:0036211	protein ubiquitination;kinase activator activity;signaling;protein modification process	14.07.05;18.02.01.01.05;30.01	modification by ubiquitination, deubiquitination;kinase activator;cellular signalling	11460167	TRIKA1 is a dimeric ubiquitin-conjugating enzyme complex composed of UBE2N and UBE2V1 or the functionally equivalent UBE2V2. This Ubiquitin-protein ligase complex, together with TRAF6, catalyses the formation of a Lys 63 (K63)-linked polyubiquitin chain that mediates IKK activation through a unique proteasome-independent mechanism.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Ubiquitin-conjugating enzyme E2 N;Ubiquitin-conjugating enzyme E2 variant 2	UBE2N;UBE2V2	BLU;MMS2, UEV2
2757	SMN complex, U7 snRNA specific	Human	None	HeLa cells	P14678;P62304;P62306;P62308;P62318;P83369;Q969L4	6628;6635;6636;6637;6634;134353;84967	MI:0019-coimmunoprecipitation	GO:0008380;GO:0032774;GO:0003723;GO:0005737;GO:0005634;GO:0065003	RNA splicing;RNA biosynthetic process;RNA binding;cytoplasm;nucleus;protein-containing complex assembly	11.04.03.01;11.02;16.03.03;70.03;70.10	splicing;RNA synthesis;RNA binding;cytoplasm;nucleus	12975319	The Lsm11 protein of the U7 snRNA specific SMN complex plays an important role in histone RNA 3' end processing.	Spinal muscular atrophy (SMA)	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Small nuclear ribonucleoprotein-associated proteins B and B';Small nuclear ribonucleoprotein E;Small nuclear ribonucleoprotein F;Small nuclear ribonucleoprotein G;Small nuclear ribonucleoprotein Sm D3;U7 snRNA-associated Sm-like protein LSm11;U7 snRNA-associated Sm-like protein LSm10	SNRPB;SNRPE;SNRPF;SNRPG;SNRPD3;LSM11;LSM10	COD SNRPB1;None;PBSCF;PBSCG;None;None;None
2758	TAK1 complex	Human	TRIKA2 protein kinase complex (TAK1, TAB1, TAB2)	HeLa cells; HEK293 cells	O43318;Q15750;Q9NYJ8	6885;10454;23118	MI:0019-coimmunoprecipitation;MI:0091-chromatography technology	GO:0006468;GO:0007249;GO:0007254	protein phosphorylation;I-kappaB kinase/NF-kappaB signaling;JNK cascade	14.07.03;30.01.05.01.04;30.01.05.01.02	modification by phosphorylation, dephosphorylation, autophosphorylation;NIK-I-kappaB/NF-kappaB cascade;JNK cascade	11460167	TAK1 complex stimulates IKK/NF-kappaB in the presence of UBC13-UEV1A complex and TRAF6.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mitogen-activated protein kinase kinase kinase 7;TGF-beta-activated kinase 1 and MAP3K7-binding protein 1;TGF-beta-activated kinase 1 and MAP3K7-binding protein 2	MAP3K7;TAB1;TAB2	TAK1;MAP3K7IP1;KIAA0733, MAP3K7IP2
2759	MBD1-MCAF complex	Human	None	None	Q6VMQ6;Q9UIS9	55729;4152	MI:0006-anti bait coimmunoprecipitation;MI:0096-pull down	GO:0006265;GO:0045892;GO:0051276;GO:0005634	DNA topological change;negative regulation of DNA-templated transcription;chromosome organization;nucleus	10.01.09.05;11.02.03.04.03;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription repression;organization of chromosome structure;nucleus	12665582	MBD1 directly prevents transcription from methylated promoters in a histone deacetylation-independent manner, through interacting with MCAF. MBD1 competes with Sp1 for binding to MCAF. MBD1-MCAF complex blocks transcription through affecting Sp1 on methylated promoter regions.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Activating transcription factor 7-interacting protein 1;Methyl-CpG-binding domain protein 1	ATF7IP;MBD1	MCAF MCAF1;CXXC3 PCM1
2760	SMAD3-SMAD4-FOXO3 complex	Human	None	epithelium	O43524;P84022;Q13485	2309;4088;4089	MI:0007-anti tag coimmunoprecipitation	GO:2001141;GO:0006355;GO:0003677;GO:0007179;GO:0005634	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;DNA binding;transforming growth factor beta receptor signaling pathway;nucleus	11.02.03.04;16.03.01;30.05.01.18.01;70.10	transcriptional control;DNA binding;TGF-beta-receptor signalling pathway;nucleus	15084259	Endogenous FoxO1, FoxO3, and FoxO4 bind to endogenous Smad2/3 and Smad4. Formation of these complexes was absolutely dependent on TGF-beta stimulation, as was the formation of a Smad2/3-Smad4 complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Forkhead box protein O3;Mothers against decapentaplegic homolog 3;Mothers against decapentaplegic homolog 4	FOXO3;SMAD3;SMAD4	FKHRL1, FOXO3A;MADH3;DPC4 MADH4
2761	SMAD3-SMAD4-FOXO1 complex	Human	None	epithelium	P84022;Q12778;Q13485	4088;2308;4089	MI:0007-anti tag coimmunoprecipitation	GO:2001141;GO:0006355;GO:0003677;GO:0007179;GO:0005634	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;DNA binding;transforming growth factor beta receptor signaling pathway;nucleus	11.02.03.04;16.03.01;30.05.01.18.01;70.10	transcriptional control;DNA binding;TGF-beta-receptor signalling pathway;nucleus	15084259	Endogenous FoxO1, FoxO3, and FoxO4 bind to endogenous Smad2/3 and Smad4. Formation of these complexes was absolutely dependent on TGF-beta stimulation, as was the formation of a Smad2/3-Smad4 complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mothers against decapentaplegic homolog 3;Forkhead box protein O1;Mothers against decapentaplegic homolog 4	SMAD3;FOXO1;SMAD4	MADH3;FKHR FOXO1A;DPC4 MADH4
2762	SMAD3-SMAD4-FOXO4 complex	Human	None	epithelium	P84022;P98177;Q13485	4088;4303;4089	MI:0007-anti tag coimmunoprecipitation	GO:2001141;GO:0006355;GO:0003677;GO:0007179;GO:0005634	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;DNA binding;transforming growth factor beta receptor signaling pathway;nucleus	11.02.03.04;16.03.01;30.05.01.18.01;70.10	transcriptional control;DNA binding;TGF-beta-receptor signalling pathway;nucleus	15084259	Endogenous FoxO1, FoxO3, and FoxO4 bind to endogenous Smad2/3 and Smad4. Formation of these complexes was absolutely dependent on TGF-beta stimulation, as was the formation of a Smad2/3-Smad4 complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mothers against decapentaplegic homolog 3;Forkhead box protein O4;Mothers against decapentaplegic homolog 4	SMAD3;FOXO4;SMAD4	MADH3;AFX AFX1 MLLT7;DPC4 MADH4
2763	MBD1-Suv39h1-HP1 complex	Human	None	None	O43463;P45973;Q9UIS9	6839;23468;4152	MI:0006-anti bait coimmunoprecipitation;MI:0096-pull down	GO:0006349;GO:0045892;GO:0006479;GO:0005634	regulation of gene expression by genomic imprinting;negative regulation of DNA-templated transcription;protein methylation;nucleus	10.01.09.07;11.02.03.04.03;14.07.09;70.10	DNA imprinting and other epigenetic effects;transcription repression;posttranslational modification of amino acids (e.g. hydroxylation, methylation);nucleus	12711603	MBD1 tethers the Suv39h1-HP1 complex to methylated DNA regions. MBD1 interacts with Suv39h1-HP1 complex via MBD domain.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone-lysine N-methyltransferase SUV39H1;Chromobox protein homolog 5;Methyl-CpG-binding domain protein 1	SUV39H1;CBX5;MBD1	KMT1A, SUV39H;HP1A;CXXC3 PCM1
2764	PRMT5 complex	Human	None	None	O14744	10419	MI:0007-anti tag coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0018126;GO:0006479;GO:0005737	protein hydroxylation;protein methylation;cytoplasm	14.07.09;70.03	posttranslational modification of amino acids (e.g. hydroxylation, methylation);cytoplasm	11152681	PRMT5 (protein-arginine methyltransferase) formes distinct homo-oligomeric complexes, including a dimer and tetramer. Recombinant PRMT5 protein methylates myelin basic protein, histone, and the amino terminus of fibrillarin.	None	None	Homo sapiens (Human)	Protein arginine N-methyltransferase 5	PRMT5	HRMT1L5 IBP72 JBP1 SKB1
2765	PRMT1 complex	Human	None	None	Q99873	3276	MI:0007-anti tag coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0018126;GO:0006479;GO:0005634	protein hydroxylation;protein methylation;nucleus	14.07.09;70.10	posttranslational modification of amino acids (e.g. hydroxylation, methylation);nucleus	11152681	PRMT1 (protein-arginine methyltransferase) formes distinct homo-oligomeric complexes, including a dimer and tetramer.	None	None	Homo sapiens (Human)	Protein arginine N-methyltransferase 1	PRMT1	HMT2 HRMT1L2 IR1B4
2766	TERF2-RAP1 complex	Human	None	None	P12956;P13010;P49959;Q15554;Q92878;Q9BSI4;Q9NYB0	2547;7520;4361;7014;10111;26277;54386	MI:0007-anti tag coimmunoprecipitation	GO:0003677;GO:0006974;GO:0051276;GO:0005634	DNA binding;cellular response to DNA damage stimulus;chromosome organization;nucleus	16.03.01;32.01.09;42.10.03;70.10	DNA binding;DNA damage response;organization of chromosome structure;nucleus	15383534	This complex is responsible for proper maintenance of telomere length and structure.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	X-ray repair cross-complementing protein 6;X-ray repair cross-complementing protein 5;Double-strand break repair protein MRE11;Telomeric repeat-binding factor 2;DNA repair protein RAD50;TERF1-interacting nuclear factor 2;Telomeric repeat-binding factor 2-interacting protein 1	XRCC6;XRCC5;MRE11;TERF2;RAD50;TINF2;TERF2IP	G22P1;G22P2;HNGS1 MRE11A;TRBF2, TRF2;None;TIN2;DRIP5, RAP1
2767	RAD50-MRE11-NBN-p200-p350 complex	Human	None	IMR-90 cells	O60934;P49959;Q92878	4683;4361;10111	MI:0006-anti bait coimmunoprecipitation	GO:0006281;GO:0000075;GO:0003677;GO:0006974;GO:0005634	DNA repair;cell cycle checkpoint signaling;DNA binding;cellular response to DNA damage stimulus;nucleus	10.01.05.01;10.03.01.03;16.03.01;32.01.09;70.10	DNA repair;cell cycle checkpoints (checkpoints of morphogenesis, DNA-damage,-replication, mitotic phase and spindle);DNA binding;DNA damage response;nucleus	8756642	None	None	Two other subunits of the complex were found in the analysis, which have not been further characterized: p350 and p200.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Nibrin;Double-strand break repair protein MRE11;DNA repair protein RAD50	NBN;MRE11;RAD50	NBS NBS1 P95;HNGS1 MRE11A;None
2770	ITGA6-ITGB4-CD9 complex	Human	integrin complex	skin	P16144;P21926;P23229	3691;928;3655	MI:0024-confirmational text mining	GO:0048870	cell motility	None	None	10711425	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-4;CD9 antigen;Integrin alpha-6	ITGB4;CD9;ITGA6	None;MIC3, TSPAN29;None
2772	Ubiquitin E3 ligase (CRY1, SKP1A, CUL1, FBXL3)	Human	SCF(FBXL3) ubiquitin ligase complex	None	P63208;Q13616;Q16526;Q9UKT7	6500;8454;1407;26224	MI:0007-anti tag coimmunoprecipitation	GO:0016567;GO:0043161;GO:0006511;GO:0007624;GO:0048511;GO:0005634	protein ubiquitination;proteasome-mediated ubiquitin-dependent protein catabolic process;ubiquitin-dependent protein catabolic process;ultradian rhythm;rhythmic process;nucleus	14.07.05;14.13.01.01;34.11.11;70.10	modification by ubiquitination, deubiquitination;proteasomal degradation (ubiquitin/proteasomal pathway);rhythm (e.g. circadian, ultradian);nucleus	17463251	Ubiquitin E3 ligases covalently attach ubiquitin to a lysine residue on a target protein. Polyubiquitination marks proteins for degradation by the proteasome. Cry1 and Cry2, encode inhibitors of the Clock-Bmal1 complex that establish a negative-feedback loop. Cry1 and Cry2 proteins are ubiquitinated and degraded via the SCF(Fbxl3) ubiquitin ligase complex. This regulation by SCF(Fbxl3) is a prerequisite for the efficient and timely reactivation of Clock-Bmal1 and the consequent expression of Per1 and Per2, two regulators of the circadian clock that display tumor suppressor activity.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	S-phase kinase-associated protein 1;Cullin-1;Cryptochrome-1;F-box/LRR-repeat protein 3	SKP1;CUL1;CRY1;FBXL3	EMC19 OCP2 SKP1A TCEB1L;None;PHLL1;FBL3A FBXL3A
2773	Ubiquitin E3 ligase (CRY2, SKP1A, CUL1, FBXL3)	Human	SCF(FBXL3) ubiquitin ligase complex	None	P63208;Q13616;Q49AN0;Q9UKT7	6500;8454;1408;26224	MI:0007-anti tag coimmunoprecipitation	GO:0016567;GO:0043161;GO:0006511;GO:0007624;GO:0048511;GO:0005634	protein ubiquitination;proteasome-mediated ubiquitin-dependent protein catabolic process;ubiquitin-dependent protein catabolic process;ultradian rhythm;rhythmic process;nucleus	14.07.05;14.13.01.01;34.11.11;70.10	modification by ubiquitination, deubiquitination;proteasomal degradation (ubiquitin/proteasomal pathway);rhythm (e.g. circadian, ultradian);nucleus	17463251	Ubiquitin E3 ligases covalently attach ubiquitin to a lysine residue on a target protein. Polyubiquitination marks proteins for degradation by the proteasome. Cry1 and Cry2, encode inhibitors of the Clock-Bmal1 complex that establish a negative-feedback loop. Cry1 and Cry2 proteins are ubiquitinated and degraded via the SCF(Fbxl3) ubiquitin ligase complex. This regulation by SCF(Fbxl3) is a prerequisite for the efficient and timely reactivation of Clock-Bmal1 and the consequent expression of Per1 and Per2, two regulators of the circadian clock that display tumor suppressor activity.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	S-phase kinase-associated protein 1;Cullin-1;Cryptochrome-2;F-box/LRR-repeat protein 3	SKP1;CUL1;CRY2;FBXL3	EMC19 OCP2 SKP1A TCEB1L;None;KIAA0658;FBL3A FBXL3A
2774	MDC1-H2AFX-TP53BP1 complex	Human	None	None	P16104;Q12888;Q14676	3014;7158;9656	MI:0006-anti bait coimmunoprecipitation	GO:0006281;GO:0000075;GO:0003677;GO:0006974;GO:0005634	DNA repair;cell cycle checkpoint signaling;DNA binding;cellular response to DNA damage stimulus;nucleus	10.01.05.01;10.03.01.03;16.03.01;32.01.09;70.10	DNA repair;cell cycle checkpoints (checkpoints of morphogenesis, DNA-damage,-replication, mitotic phase and spindle);DNA binding;DNA damage response;nucleus	12607005	MDC1 forms complexes with phosporylated H2AFX.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone H2AX;TP53-binding protein 1;Mediator of DNA damage checkpoint protein 1	H2AX;TP53BP1;MDC1	H2AFX;None;KIAA0170 NFBD1
2775	MDC1-p53BP1-SMC1 complex	Human	None	None	Q12888;Q14676;Q14683	7158;9656;8243	MI:0006-anti bait coimmunoprecipitation	GO:0006281;GO:0000075;GO:0003677;GO:0005634	DNA repair;cell cycle checkpoint signaling;DNA binding;nucleus	10.01.05.01;10.03.01.03;16.03.01;70.10	DNA repair;cell cycle checkpoints (checkpoints of morphogenesis, DNA-damage,-replication, mitotic phase and spindle);DNA binding;nucleus	12607005	Interaction of MDC1 with 53BP1 and SMC1 is unaffected by DNA damage.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	TP53-binding protein 1;Mediator of DNA damage checkpoint protein 1;Structural maintenance of chromosomes protein 1A	TP53BP1;MDC1;SMC1A	None;KIAA0170 NFBD1;DXS423E KIAA0178 SB1.8 SMC1 SMC1L1
2776	RAD50-BRCA1 complex	Human	None	None	P38398;Q92878	672;10111	MI:0007-anti tag coimmunoprecipitation;MI:0226-ion exchange chromatography	GO:0006281;GO:0005634	DNA repair;nucleus	10.01.05.01;70.10	DNA repair;nucleus	11504724	None	BRCA1 is involved in breast cancer.	None	Homo sapiens (Human);Homo sapiens (Human)	Breast cancer type 1 susceptibility protein;DNA repair protein RAD50	BRCA1;RAD50	RNF53;None
2783	BARD1-BRCA1-CSTF64 complex	Human	None	None	P33240;P38398;Q99728	1478;672;580	MI:0006-anti bait coimmunoprecipitation	GO:0031123;GO:0031124;GO:0006974;GO:0005634	RNA 3'-end processing;mRNA 3'-end processing;cellular response to DNA damage stimulus;nucleus	11.04.03.05;32.01.09;70.10	3'-end processing;DNA damage response;nucleus	11257228	DNA damage increases formation of a CstF-BARD1-BRCA1 inhibitory complex. Complex formation represses polyadenylation of mRNA.	BRCA1 is involved in breast cancer.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cleavage stimulation factor subunit 2;Breast cancer type 1 susceptibility protein;BRCA1-associated RING domain protein 1	CSTF2;BRCA1;BARD1	None;RNF53;None
2786	BRCA1 A complex	Human	None	None	P38398;Q6UWZ7;Q96RL1;Q99728	672;84142;51720;580	MI:0019-coimmunoprecipitation	GO:0006281;GO:0000075;GO:0009314;GO:0005634	DNA repair;cell cycle checkpoint signaling;response to radiation;nucleus	10.01.05.01;10.03.01.03;32.01.13;70.10	DNA repair;cell cycle checkpoints (checkpoints of morphogenesis, DNA-damage,-replication, mitotic phase and spindle);electromagnetic waves stress response (e.g. UV, X-ray);nucleus	17525340	None	BRCA1 is involved in breast cancer.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Breast cancer type 1 susceptibility protein;BRCA1-A complex subunit Abraxas 1;BRCA1-A complex subunit RAP80;BRCA1-associated RING domain protein 1	BRCA1;ABRAXAS1;UIMC1;BARD1	RNF53;ABRA1 CCDC98 FAM175A;RAP80 RXRIP110;None
2787	BRCA1 C complex	Human	None	None	P38398;Q96RL1;Q99708;Q99728	672;51720;5932;580	MI:0019-coimmunoprecipitation	GO:0006310;GO:0000075;GO:0005634	DNA recombination;cell cycle checkpoint signaling;nucleus	10.01.05.03;10.03.01.03;70.10	DNA recombination;cell cycle checkpoints (checkpoints of morphogenesis, DNA-damage,-replication, mitotic phase and spindle);nucleus	17525340	None	BRCA1 is involved in breast cancer.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Breast cancer type 1 susceptibility protein;BRCA1-A complex subunit RAP80;DNA endonuclease RBBP8;BRCA1-associated RING domain protein 1	BRCA1;UIMC1;RBBP8;BARD1	RNF53;RAP80 RXRIP110;CTIP;None
2788	BRCA1 B complex	Human	None	None	O14867;P38398;Q99728	571;672;580	MI:0019-coimmunoprecipitation	GO:0006310;GO:0005634	DNA recombination;nucleus	10.01.05.03;70.10	DNA recombination;nucleus	17525340	None	BRCA1 is involved in breast cancer.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transcription regulator protein BACH1;Breast cancer type 1 susceptibility protein;BRCA1-associated RING domain protein 1	BACH1;BRCA1;BARD1	None;RNF53;None
2789	ETS2-ERG complex	Human	None	None	P11308;P15036	2078;2114	MI:0018-two hybrid;MI:0096-pull down	GO:2001141;GO:0006355;GO:0003677;GO:0005634	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;DNA binding;nucleus	11.02.03.04;16.03.01;70.10	transcriptional control;DNA binding;nucleus	9334186	The authors found that different domains of ETS2 make contacts with the Fos/Jun complex and with other members of the Ets family to form stable heterotrimeric ETS2/Fos/Jun and heterodimeric ETS2/ERG and ETS2/ETS1 complexes.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Transcriptional regulator ERG;Protein C-ets-2	ERG;ETS2	None;
2790	ETS2-ETS1 complex	Human	None	None	P14921;P15036	2113;2114	MI:0018-two hybrid;MI:0096-pull down	GO:2001141;GO:0006355;GO:0003677;GO:0005634	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;DNA binding;nucleus	11.02.03.04;16.03.01;70.10	transcriptional control;DNA binding;nucleus	9334186	The authors found that different domains of ETS2 make contacts with the Fos/Jun complex and with other members of the Ets family to form stable heterotrimeric ETS2/Fos/Jun and heterodimeric ETS2/ERG and ETS2/ETS1 complexes.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Protein C-ets-1;Protein C-ets-2	ETS1;ETS2	EWSR2;
2791	MCM4-MCM6-MCM7 complex	Human	None	None	P33991;P33993;Q14566	4173;4176;4175	MI:0091-chromatography technology	GO:0051276;GO:0006260;GO:0005524;GO:0005634	chromosome organization;DNA replication;ATP binding;nucleus	42.10.03;10.01.03;16.19.03;70.10	organization of chromosome structure;DNA synthesis and replication;ATP binding;nucleus	9305914	This complex has DNA helicase activity.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA replication licensing factor MCM4;DNA replication licensing factor MCM7;DNA replication licensing factor MCM6	MCM4;MCM7;MCM6	CDC21;CDC47 MCM2;None
2792	MCM2-MCM4-MCM6-MCM7 complex	Human	None	None	P33991;P33993;P49736;Q14566	4173;4176;4171;4175	MI:0029-cosedimentation through density gradient;MI:0091-chromatography technology	GO:0051276;GO:0006260;GO:0005524;GO:0005634	chromosome organization;DNA replication;ATP binding;nucleus	42.10.03;10.01.03;16.19.03;70.10	organization of chromosome structure;DNA synthesis and replication;ATP binding;nucleus	9305914	This complex has DNA helicase activity.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA replication licensing factor MCM4;DNA replication licensing factor MCM7;DNA replication licensing factor MCM2;DNA replication licensing factor MCM6	MCM4;MCM7;MCM2;MCM6	CDC21;CDC47 MCM2;BM28 CCNL1 CDCL1 KIAA0030;None
2797	PCNA-CHL12-RFC2-5 complex	Human	None	None	P12004;P35249;P35250;P40937;P40938;Q8WVB6	5111;5984;5982;5985;5983;63922	MI:0007-anti tag coimmunoprecipitation	GO:0006260;GO:0005634	DNA replication;nucleus	10.01.03;70.10	DNA synthesis and replication;nucleus	12171929	CHL12-RFC2-5 functions as a novel clamp loader protein.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Proliferating cell nuclear antigen;Replication factor C subunit 4;Replication factor C subunit 2;Replication factor C subunit 5;Replication factor C subunit 3;Chromosome transmission fidelity protein 18 homolog	PCNA;RFC4;RFC2;RFC5;RFC3;CHTF18	None;None;None;None;None;C16orf41 CTF18
2798	CLDN1-MMP2 complex	Human	CLG4A-CLDN1 complex	293T cells	O95832;P08253	9076;4313	MI:0006-anti bait coimmunoprecipitation	GO:0008237	metallopeptidase activity	None	None	11382769	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Claudin-1;72 kDa type IV collagenase	CLDN1;MMP2	CLD1 SEMP1;CLG4A
2801	OCT4-SOX2 DNA-protein complex	Human	None	None	P48431;Q01860	6657;5460	MI:0413-electrophoretic mobility shift assay	GO:2001141;GO:0006355;GO:0003677;GO:0009792;GO:0005634	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;DNA binding;embryo development ending in birth or egg hatching;nucleus	11.02.03.04;16.03.01;41.05.04.01;70.10	transcriptional control;DNA binding;early embryogenesis;nucleus	12923055	The authors analyzed the interaction of the two transcription factors Oct4 with Sox2 on the DNA enhancers of FGF4 (fibroblast growth factor 4) and UTF1 (undifferentiated transcription factor 1). The structural models revealed that the FGF4 and the UTF1  enhancers mediate the assembly of distinct POU/HMG-domain complexes, leading to different quaternary arrangements by swapping protein-protein interaction surfaces of Sox2.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Transcription factor SOX-2;POU domain, class 5, transcription factor 1	SOX2;POU5F1	None;OCT3 OCT4 OTF3
2802	OCT1-SOX2 DNA-protein complex	Human	None	None	P14859;P48431	5451;6657	MI:0114-x-ray crystallography;MI:0413-electrophoretic mobility shift assay	GO:2001141;GO:0006355;GO:0003677;GO:0009792;GO:0005634	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;DNA binding;embryo development ending in birth or egg hatching;nucleus	11.02.03.04;16.03.01;41.05.04.01;70.10	transcriptional control;DNA binding;early embryogenesis;nucleus	12923055	The authors analyzed the interaction of the two transcription factors Oct1 with Sox2 on the DNA enhancers of FGF4 (fibroblast growth factor 4) and UTF1 (undifferentiated transcription factor 1). The structural models revealed that the FGF4 and the UTF1  enhancers mediate the assembly of distinct POU/HMG-domain complexes, leading to different quaternary arrangements by swapping protein-protein interaction surfaces of Sox2.	None	None	Homo sapiens (Human);Homo sapiens (Human)	POU domain, class 2, transcription factor 1;Transcription factor SOX-2	POU2F1;SOX2	OCT1 OTF1;None
2803	PAX6-SOX2 DNA-protein complex	Human	None	None	P26367;P48431	5080;6657	MI:0413-electrophoretic mobility shift assay	GO:2001141;GO:0006355;GO:0003677;GO:0032504;GO:0001654;GO:0005634	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;DNA binding;multicellular organism reproduction;eye development;nucleus	11.02.03.04;16.03.01;41.05.04.03;47.03.02.02;70.10	transcriptional control;DNA binding;late embryogenesis ;eye;nucleus	12923055	The authors analyzed the interaction of the two transcription factors Pax6 with Sox2 on the DNA enhancer of DC5. It was demonstrated that the same Sox2 interface (the C-terminal region of HMG) is required for heterodimer formation with Oct4 on FGF4 and with Pax6 on DC5, although these two Sox2 partners are members of different transcription factor families and, as such, both unrelated in sequence and structure.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Paired box protein Pax-6;Transcription factor SOX-2	PAX6;SOX2	AN2;None
2804	CTF18-cohesion-RFC complex	Human	CTF18-RFC complex	None	P0CG13;P35249;P35250;P40937;P40938;Q8WVB6;Q9BVC3	54921;5984;5982;5985;5983;63922;79075	MI:0007-anti tag coimmunoprecipitation	GO:0006260;GO:0007059;GO:0003677;GO:0051276;GO:0005634	DNA replication;chromosome segregation;DNA binding;chromosome organization;nucleus	10.01.03;10.03.04.05;16.03.01;42.10.03;70.10	DNA synthesis and replication;chromosome segregation/division;DNA binding;organization of chromosome structure;nucleus	12930902	CTF18-RFC complex interacts with PCNA homotrimer in the pressence of ATP and loads PCNA onto primed and gapped circular DNA, but not onto nicked or single-stranded circular DNA.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Chromosome transmission fidelity protein 8 homolog;Replication factor C subunit 4;Replication factor C subunit 2;Replication factor C subunit 5;Replication factor C subunit 3;Chromosome transmission fidelity protein 18 homolog;Sister chromatid cohesion protein DCC1	CHTF8;RFC4;RFC2;RFC5;RFC3;CHTF18;DSCC1	CTF8;None;None;None;None;C16orf41 CTF18;DCC1
2805	CTF8-DCC1 subcomplex	Human	None	None	P0CG13;Q9BVC3	54921;79075	MI:0007-anti tag coimmunoprecipitation	GO:0007059;GO:0005515;GO:0051276;GO:0005634	chromosome segregation;protein binding;chromosome organization;nucleus	10.03.04.05;16.01;42.10.03;70.10	chromosome segregation/division;protein binding;organization of chromosome structure;nucleus	12930902	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Chromosome transmission fidelity protein 8 homolog;Sister chromatid cohesion protein DCC1	CHTF8;DSCC1	CTF8;DCC1
2809	9-1-1-APE1 complex	Human	APE1-HUS1-RAD1A-RAD9 complex	HEK293T cells	O60671;O60921;P27695;Q99638	5810;3364;328;5883	MI:0006-anti bait coimmunoprecipitation;MI:0096-pull down	GO:0006281;GO:0000075;GO:0006974;GO:0005634;GO:0006284	DNA repair;cell cycle checkpoint signaling;cellular response to DNA damage stimulus;nucleus;base-excision repair	10.01.05.01;10.03.01.03;32.01.09;70.10	DNA repair;cell cycle checkpoints (checkpoints of morphogenesis, DNA-damage,-replication, mitotic phase and spindle);DNA damage response;nucleus	17426133	The 9-1-1 complex specifically stimulates the endonuclease activity of APEX1 for DNA repair.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cell cycle checkpoint protein RAD1;Checkpoint protein HUS1;DNA-(apurinic or apyrimidinic site) endonuclease;Cell cycle checkpoint control protein RAD9A	RAD1;HUS1;APEX1;RAD9A	REC1;None;APE APE1 APEX APX HAP1 REF1;None
2811	BRCA1-cABL complex	Human	None	HEK293 cells	P00519;P38398	25;672	MI:0006-anti bait coimmunoprecipitation	GO:0009314;GO:0004713	response to radiation;protein tyrosine kinase activity	32.01.13	electromagnetic waves stress response (e.g. UV, X-ray)	12024016	BRCA1 controls c-Abl activity. Interaction occurs between th PXXP motif in the C-terminus of BRCA1 and the SH3 domain of c-Abl.	BRCA1 is involved in breast cancer.	None	Homo sapiens (Human);Homo sapiens (Human)	Tyrosine-protein kinase ABL1;Breast cancer type 1 susceptibility protein	ABL1;BRCA1	ABL, JTK7;RNF53
2812	RPAP1-RPB2-RPB3 complex	Human	None	None	P19387;P30876;Q9BWH6	5432;5431;26015	MI:0004-affinity chromatography technology	GO:0006351;GO:0005634	DNA-templated transcription;nucleus	11;70.10	TRANSCRIPTION;nucleus	15282305	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA-directed RNA polymerase II subunit RPB3;DNA-directed RNA polymerase II subunit RPB2;RNA polymerase II-associated protein 1	POLR2C;POLR2B;RPAP1	None;None;KIAA1403
2813	BRCA1-SMAD3 complex	Human	None	None	P38398;P84022	672;4088	MI:0007-anti tag coimmunoprecipitation;MI:0096-pull down	GO:0006281;GO:0007049;GO:2001141;GO:0006355;GO:0007179;GO:0005634	DNA repair;cell cycle;regulation of RNA biosynthetic process;regulation of DNA-templated transcription;transforming growth factor beta receptor signaling pathway;nucleus	10.01.05.01;10.03;11.02.03.04;30.05.01.18.01;70.10	DNA repair;cell cycle;transcriptional control;TGF-beta-receptor signalling pathway;nucleus	15735739	Interaction is mediated by the MH1 domain of Smad3 and the C-terminal part of BRCA1.	BRCA1 is involved in breast cancer.	None	Homo sapiens (Human);Homo sapiens (Human)	Breast cancer type 1 susceptibility protein;Mothers against decapentaplegic homolog 3	BRCA1;SMAD3	RNF53;MADH3
2814	BRCA1-HDAC1-HDAC2 complex	Human	None	None	P38398;Q13547;Q92769	672;3065;3066	MI:0007-anti tag coimmunoprecipitation	GO:0006281;GO:0006476;GO:0005634	DNA repair;protein deacetylation;nucleus	10.01.05.01;14.07.04;70.10	DNA repair;modification by acetylation, deacetylation;nucleus	10220405	BRCA1 interacts with components of the histone deacetylase complex, and therefore may explain the involvement of BRCA1 in multiple processes such as transcription, DNA repair, and recombination. BRCA1 associates with HDAC1 and HDAC2 via the BRCT domain.	BRCA1 is involved in breast cancer.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Breast cancer type 1 susceptibility protein;Histone deacetylase 1;Histone deacetylase 2	BRCA1;HDAC1;HDAC2	RNF53;RPD3L1;None
2815	BRCA1-BARD1-BACH1-DNA damage complex II	Human	None	None	O14867;O60934;P38398;P49959;Q92547;Q92878;Q99708;Q99728	571;4683;672;4361;11073;10111;5932;580	MI:0006-anti bait coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0006260;GO:0006281;GO:0000075;GO:0006974;GO:0005634	DNA replication;DNA repair;cell cycle checkpoint signaling;cellular response to DNA damage stimulus;nucleus	10.01.03;10.01.05.01;10.03.01.03;32.01.09;70.10	DNA synthesis and replication;DNA repair;cell cycle checkpoints (checkpoints of morphogenesis, DNA-damage,-replication, mitotic phase and spindle);DNA damage response;nucleus	16391231	This complex occurs after exposure to UV irradiation.	BRCA1 is involved in breast cancer.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transcription regulator protein BACH1;Nibrin;Breast cancer type 1 susceptibility protein;Double-strand break repair protein MRE11;DNA topoisomerase 2-binding protein 1;DNA repair protein RAD50;DNA endonuclease RBBP8;BRCA1-associated RING domain protein 1	BACH1;NBN;BRCA1;MRE11;TOPBP1;RAD50;RBBP8;BARD1	None;NBS NBS1 P95;RNF53;HNGS1 MRE11A;KIAA0259;None;CTIP;None
2816	ITGAV-ITGB3 complex	Human	alphaV-beta3 integrin complex	SW480 cells	P05106;P06756	3690;3685	MI:0019-coimmunoprecipitation	GO:0005515;GO:0016477;GO:0007155;GO:0016049;GO:0008305	protein binding;cell migration;cell adhesion;cell growth;integrin complex	16.01;34.05.01;34.07;40.01	protein binding;cell migration;cell adhesion;cell growth / morphogenesis	8798654	Alpha(v)beta3 can differentially activate cell migration and intracellular signaling pathways in a ligand-specific manner (PMID:10835423).	None	None	Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-3;Integrin alpha-V	ITGB3;ITGAV	GP3A;MSK8 VNRA VTNR
2817	BRCA1-BARD1-BACH1-DNA damage complex I	Human	None	None	O14867;P38398;P40692;P52701;Q92547;Q99728	571;672;4292;2956;11073;580	MI:0006-anti bait coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0006260;GO:0006281;GO:0000075;GO:0006974;GO:0005634	DNA replication;DNA repair;cell cycle checkpoint signaling;cellular response to DNA damage stimulus;nucleus	10.01.03;10.01.05.01;10.03.01.03;32.01.09;70.10	DNA synthesis and replication;DNA repair;cell cycle checkpoints (checkpoints of morphogenesis, DNA-damage,-replication, mitotic phase and spindle);DNA damage response;nucleus	16391231	This complex occurs after exposure to UV irradiation. BRCA1-BARD1-BACH1 complex is required for post-damage interaction with TOPBP1.	BRCA1 is involved in breast cancer.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transcription regulator protein BACH1;Breast cancer type 1 susceptibility protein;DNA mismatch repair protein Mlh1;DNA mismatch repair protein Msh6;DNA topoisomerase 2-binding protein 1;BRCA1-associated RING domain protein 1	BACH1;BRCA1;MLH1;MSH6;TOPBP1;BARD1	None;RNF53;COCA2;GTBP;KIAA0259;None
2818	BRCA1-BARD1-BRCA2-DNA damage complex III	Human	None	None	P38398;P51587;Q99728	672;675;580	MI:0006-anti bait coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0006260;GO:0006281;GO:0000075;GO:0006974;GO:0005634	DNA replication;DNA repair;cell cycle checkpoint signaling;cellular response to DNA damage stimulus;nucleus	10.01.03;10.01.05.01;10.03.01.03;32.01.09;70.10	DNA synthesis and replication;DNA repair;cell cycle checkpoints (checkpoints of morphogenesis, DNA-damage,-replication, mitotic phase and spindle);DNA damage response;nucleus	16391231	This complex occurs after exposure to UV irradiation.	BRCA1 is involved in breast cancer.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Breast cancer type 1 susceptibility protein;Breast cancer type 2 susceptibility protein;BRCA1-associated RING domain protein 1	BRCA1;BRCA2;BARD1	RNF53;FACD FANCD1;None
2819	BRCA1-CtIP-CtBP complex	Human	None	None	P38398;Q13363;Q99708	672;1487;5932	MI:0006-anti bait coimmunoprecipitation	GO:0006281;GO:2001141;GO:0006355;GO:0006974;GO:0005634	DNA repair;regulation of RNA biosynthetic process;regulation of DNA-templated transcription;cellular response to DNA damage stimulus;nucleus	10.01.05.01;11.02.03.04;32.01.09;70.10	DNA repair;transcriptional control;DNA damage response;nucleus	10196224	BRCA1 binds to CtBP through CtIP. Binding of BRCA1 to CtIP/CtBP is critical in mediating transcriptional regulation of p21 in response to DNA damage.	BRCA1 is involved in breast cancer.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Breast cancer type 1 susceptibility protein;C-terminal-binding protein 1;DNA endonuclease RBBP8	BRCA1;CTBP1;RBBP8	RNF53;CTBP;CTIP
2820	BRCA1-VCP complex	Human	None	None	P38398;P55072	672;7415	MI:0019-coimmunoprecipitation	GO:0006281;GO:0005634	DNA repair;nucleus	10.01.05.01;70.10	DNA repair;nucleus	10855792	VCP participates in the DNA damage-repair function as an ATP transporter, possibly facilitating the transcription-coupled repair.	BRCA1 is involved in breast cancer.	None	Homo sapiens (Human);Homo sapiens (Human)	Breast cancer type 1 susceptibility protein;Transitional endoplasmic reticulum ATPase	BRCA1;VCP	RNF53;None
2821	hSIR2-p53 complex	Human	None	None	P04637;Q96EB6	7157;23411	MI:0006-anti bait coimmunoprecipitation	GO:2001141;GO:0006355;GO:0006473;GO:0006476;GO:0006974;GO:0005634	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;protein acetylation;protein deacetylation;cellular response to DNA damage stimulus;nucleus	11.02.03.04;14.07.04;32.01.09;70.10	transcriptional control;modification by acetylation, deacetylation;DNA damage response;nucleus	11672523	The authors analyzed that hSir2 directly binds the human p53 protein in vivo and specifically deacetylates the K382 residue of p53.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cellular tumor antigen p53;NAD-dependent protein deacetylase sirtuin-1	TP53;SIRT1	P53;SIR2L1
2822	E3 ubiquitin ligase (BRCA1, BARD1) - UbcH5c complex	Human	BRCA1-BARD1-UbcH5c complex	None	P38398;P61077;Q99728	672;7323;580	MI:0077-nuclear magnetic resonance	GO:0016567;GO:0006974;GO:0005634	protein ubiquitination;cellular response to DNA damage stimulus;nucleus	14.07.05;32.01.09;70.10	modification by ubiquitination, deubiquitination;DNA damage response;nucleus	12732733	UbcH5c binds to BRCA1 RING domain and not to the BARD1 RING.	BRCA1 is involved in breast cancer.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Breast cancer type 1 susceptibility protein;Ubiquitin-conjugating enzyme E2 D3;BRCA1-associated RING domain protein 1	BRCA1;UBE2D3;BARD1	RNF53;UBC5C UBCH5C;None
2823	BRCA1-BARD1-UbcH7c complex	Human	None	None	P38398;P68036;Q99728	672;7332;580	MI:0077-nuclear magnetic resonance	GO:0006974;GO:0005634	cellular response to DNA damage stimulus;nucleus	32.01.09;70.10	DNA damage response;nucleus	12732733	UbcH7c binds to BRCA1 RING domain and not to the BARD1 RING.	BRCA1 is involved in breast cancer.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Breast cancer type 1 susceptibility protein;Ubiquitin-conjugating enzyme E2 L3;BRCA1-associated RING domain protein 1	BRCA1;UBE2L3;BARD1	RNF53;UBCE7 UBCH7;None
2824	BRCA1-RAD51 complex	Human	None	None	P38398;Q06609	672;5888	MI:0006-anti bait coimmunoprecipitation	GO:0006281;GO:0006310;GO:0000075;GO:0005634	DNA repair;DNA recombination;cell cycle checkpoint signaling;nucleus	10.01.05.01;10.01.05.03;10.03.01.03;70.10	DNA repair;DNA recombination;cell cycle checkpoints (checkpoints of morphogenesis, DNA-damage,-replication, mitotic phase and spindle);nucleus	9008167	BRCA1 and RAD51 mainly colocalize in S phase cells.	BRCA1 is involved in breast cancer.	None	Homo sapiens (Human);Homo sapiens (Human)	Breast cancer type 1 susceptibility protein;DNA repair protein RAD51 homolog 1	BRCA1;RAD51	RNF53;RAD51A RECA
2825	BRCA1-RNA polymerase II complex	Human	None	None	O15514;P13984;P18074;P19387;P19388;P19447;P20226;P24928;P29083;P29084;P30876;P32780;P35269;P36954;P38398;P52434;P52435;P53803;P61218;P62487;P62875;Q00403;Q13503;Q13888;Q13889;Q92759	5433;2963;2068;5432;5434;2071;6908;5430;2960;2961;5431;2965;2962;5438;672;5437;5439;5440;5435;5436;5441;2959;9412;2966;2967;2968	MI:0006-anti bait coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0006351;GO:0003677;GO:0005634	DNA-templated transcription;DNA binding;nucleus	11;16.03.01;70.10	TRANSCRIPTION;DNA binding;nucleus	9159119	The Brca1 tumor supressor protein is associated with the transcription process.	BRCA1 is involved in breast cancer.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA-directed RNA polymerase II subunit RPB4;General transcription factor IIF subunit 2;General transcription and DNA repair factor IIH helicase subunit XPD;DNA-directed RNA polymerase II subunit RPB3;DNA-directed RNA polymerases I, II, and III subunit RPABC1;General transcription and DNA repair factor IIH helicase subunit XPB;TATA-box-binding protein;DNA-directed RNA polymerase II subunit RPB1;General transcription factor IIE subunit 1;Transcription initiation factor IIE subunit beta;DNA-directed RNA polymerase II subunit RPB2;General transcription factor IIH subunit 1;General transcription factor IIF subunit 1;DNA-directed RNA polymerase II subunit RPB9;Breast cancer type 1 susceptibility protein;DNA-directed RNA polymerases I, II, and III subunit RPABC3;DNA-directed RNA polymerase II subunit RPB11-a;DNA-directed RNA polymerases I, II, and III subunit RPABC4;DNA-directed RNA polymerases I, II, and III subunit RPABC2;DNA-directed RNA polymerase II subunit RPB7;DNA-directed RNA polymerases I, II, and III subunit RPABC5;Transcription initiation factor IIB;Mediator of RNA polymerase II transcription subunit 21;General transcription factor IIH subunit 2;General transcription factor IIH subunit 3;General transcription factor IIH subunit 4	POLR2D;GTF2F2;ERCC2;POLR2C;POLR2E;ERCC3;TBP;POLR2A;GTF2E1;GTF2E2;POLR2B;GTF2H1;GTF2F1;POLR2I;BRCA1;POLR2H;POLR2J;POLR2K;POLR2F;POLR2G;POLR2L;GTF2B;MED21;GTF2H2;GTF2H3;GTF2H4	None;RAP30;XPD XPDC;None;None;XPB XPBC;GTF2D1 TF2D TFIID;POLR2;TF2E1;TF2E2;None;BTF2;RAP74;None;RNF53;None;POLR2J1;None;POLRF;RPB7;None;TF2B TFIIB;SRB7 SURB7;BTF2P44;None;None
2826	ITGB3-ITGAV-VTN complex	Human	integrin complex	None	P04004;P05106;P06756	7448;3690;3685	MI:0004-affinity chromatography technology	GO:0016477	cell migration	34.05.01	cell migration	10835423	In beta(3)-LNCaP cells, alpha(v)beta(3) mediates cell migration and PI 3-kinase/AKT pathway activation on vitronectin, whereas adhesion to osteopontin does not support alpha(v)beta(3)-mediated cell migration and PI 3-kinase/AKT pathway activation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Vitronectin;Integrin beta-3;Integrin alpha-V	VTN;ITGB3;ITGAV	None;GP3A;MSK8 VNRA VTNR
2829	RSmad complex	Human	None	None	P51532;P84022;Q13485;Q15796;Q8NFD5;Q8TAQ2;Q92793;Q92922;Q9UPN9;Q9Y6Q9	6597;4088;4089;4087;57492;6601;1387;6599;51592;8202	MI:0004-affinity chromatography technology	GO:2001141;GO:0006355;GO:0007179;GO:0005634	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;transforming growth factor beta receptor signaling pathway;nucleus	11.02.03.04;30.05.01.18.01;70.10	transcriptional control;TGF-beta-receptor signalling pathway;nucleus	16751102	Affinity purification of proteins that selectively bind to activated RSmads.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transcription activator BRG1;Mothers against decapentaplegic homolog 3;Mothers against decapentaplegic homolog 4;Mothers against decapentaplegic homolog 2;AT-rich interactive domain-containing protein 1B;SWI/SNF complex subunit SMARCC2;CREB-binding protein;SWI/SNF complex subunit SMARCC1;E3 ubiquitin-protein ligase TRIM33;Nuclear receptor coactivator 3	SMARCA4;SMAD3;SMAD4;SMAD2;ARID1B;SMARCC2;CREBBP;SMARCC1;TRIM33;NCOA3	BAF190A BRG1 SNF2B SNF2L4;MADH3;DPC4 MADH4;MADH2 MADR2;BAF250B DAN15 KIAA1235 OSA2;BAF170;CBP;BAF155;KIAA1113 RFG7 TIF1G;AIB1 BHLHE42 RAC3 TRAM1
2830	TIF1gamma-SMAD2-SMAD3 complex	Human	None	HeLa cell extracts	P84022;Q15796;Q9UPN9	4088;4087;51592	MI:0006-anti bait coimmunoprecipitation	GO:2001141;GO:0006355;GO:0007179;GO:0030097;GO:0005634	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;transforming growth factor beta receptor signaling pathway;hemopoiesis;nucleus	11.02.03.04;30.05.01.18.01;41.05.18;70.10	transcriptional control;TGF-beta-receptor signalling pathway;hemopoiesis;nucleus	16751102	Formation of complex is dependent on TGFbeta. TIF1gamma selectively binds receptor-posphorylated SMAD2 and SMAD3 in competition with SMAD4.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mothers against decapentaplegic homolog 3;Mothers against decapentaplegic homolog 2;E3 ubiquitin-protein ligase TRIM33	SMAD3;SMAD2;TRIM33	MADH3;MADH2 MADR2;KIAA1113 RFG7 TIF1G
2833	SRm160-SRm300 complex	Human	None	None	Q8IYB3;Q9UQ35	10250;23524	MI:0019-coimmunoprecipitation	GO:0008380;GO:0003723;GO:0016363	RNA splicing;RNA binding;nuclear matrix	11.04.03.01;16.03.03;70.10.06	splicing;RNA binding;nuclear matrix	9531537	The authors demonstrate that although SRm160/300 can promote splicing in the absence of U1 snRNP, under "normal" splicing reaction conditions containing endogenous levels of SR family proteins, SRm160/300 associates with pre-mRNA by a U1 snRNP-dependent pathway and its binding to pre-mRNA is further stabilized by U2 snRNP. SRm160/300 also associates preferentially with a subset of specific SR proteins comigrating with SRp40 and SRp75. The results indicate that SRm160/300 and SR family proteins have overlapping but nonreciprocal functions and that cooperative interactions between these factors is critical for the splicing of specific pre-mRNAs.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Serine/arginine repetitive matrix protein 1;Serine/arginine repetitive matrix protein 2	SRRM1;SRRM2	SRM160;KIAA0324 SRL300 SRM300
2834	SMAD4-SMAD2-SMAD3 complex	Human	None	HeLa-S3 cells, COS-1 cells	P84022;Q13485;Q15796	4088;4089;4087	MI:0004-affinity chromatography technology;MI:0006-anti bait coimmunoprecipitation	GO:0006355;GO:0007179;GO:0005634	regulation of DNA-templated transcription;transforming growth factor beta receptor signaling pathway;nucleus	11.02.03.04;30.05.01.18.01;70.10	transcriptional control;TGF-beta-receptor signalling pathway;nucleus	16751102	Formation of complex is dependent on TGFbeta. TIF1gamma selectively binds receptor-posphorylated SMAD2 and SMAD3 in competition with SMAD4.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mothers against decapentaplegic homolog 3;Mothers against decapentaplegic homolog 4;Mothers against decapentaplegic homolog 2	SMAD3;SMAD4;SMAD2	MADH3;DPC4 MADH4;MADH2 MADR2
2838	MEP50-PRMT5-ICLN complex	Human	AR-coactivator complex; p44-PRMT-ICLN complex	HeLa cells, LNCaP cells	O14744;P54105;Q9BQA1	10419;1207;79084	MI:0007-anti tag coimmunoprecipitation	GO:0045893;GO:0003677;GO:0030850;GO:0005634;GO:0030521	positive regulation of DNA-templated transcription;DNA binding;prostate gland development;nucleus;androgen receptor signaling pathway	11.02.03.04.01;16.03.01;47.03.21.04;70.10	transcription activation;DNA binding;prostate gland;nucleus	12972618	This complex contains the protein arginine methyltransferase 5 (PRMT5), which acts synergistically with p44 (WDR77) to enhance androgen receptor-driven gene expression in a methyltransferase-independent manner.	Overexpression of WDR77 (p44) correlates with prostate tumorigenesis.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein arginine N-methyltransferase 5;Methylosome subunit pICln;Methylosome protein 50	PRMT5;CLNS1A;WDR77	HRMT1L5 IBP72 JBP1 SKB1;CLCI ICLN;MEP50 WD45
2839	ATRX-DAXX complex	Human	ATRX chromatin-remodeling complex	HeLa nuclear extracts	P46100;Q9UER7	546;1616	MI:0006-anti bait coimmunoprecipitation;MI:0071-molecular sieving	GO:0006265;GO:0006355;GO:0051276;GO:0005634	DNA topological change;regulation of DNA-templated transcription;chromosome organization;nucleus	10.01.09.05;11.02.03.04;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcriptional control;organization of chromosome structure;nucleus	12953102	ATRX and DAXX colocalize in promyelocytic leukemia nuclear bodies.	The level of this complex is significantly decreased in an ATRX patient cell line.	Two other subunits of the complex were found in the analysis, which have not been further characterized: DAP50 and DAP60.	Homo sapiens (Human);Homo sapiens (Human)	Transcriptional regulator ATRX;Death domain-associated protein 6	ATRX;DAXX	RAD54L XH2;BING2 DAP6
2842	DAXX-Axin-p53-HIPK2 complex	Human	None	None	O15169;P04637;Q9H2X6;Q9UER7	8312;7157;28996;1616	MI:0006-anti bait coimmunoprecipitation	GO:2001141;GO:0006355;GO:0006468;GO:0009314;GO:0006915;GO:0005634	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;protein phosphorylation;response to radiation;apoptotic process;nucleus	11.02.03.04;14.07.03;32.01.13;40.10.02;70.10	transcriptional control;modification by phosphorylation, dephosphorylation, autophosphorylation;electromagnetic waves stress response (e.g. UV, X-ray);apoptosis (type I programmed cell death);nucleus	17210684	Axin tethers DAXX to the tumor suppressor p53. UV induces colocalization of Axin, DAXX and HIPK2 in the nucleus.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Axin-1;Cellular tumor antigen p53;Homeodomain-interacting protein kinase 2;Death domain-associated protein 6	AXIN1;TP53;HIPK2;DAXX	AXIN;P53;None;BING2 DAP6
2844	Axin-p53-HIPK2 complex	Human	None	None	O15169;P04637;Q9H2X6	8312;7157;28996	MI:0006-anti bait coimmunoprecipitation	GO:2001141;GO:0006355;GO:0009314;GO:0006915;GO:0005634	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;response to radiation;apoptotic process;nucleus	11.02.03.04;32.01.13;40.10.02;70.10	transcriptional control;electromagnetic waves stress response (e.g. UV, X-ray);apoptosis (type I programmed cell death);nucleus	15526030	Axin stimulates the transcriptional activity of p53 selectively toward some of the p53 target genes, and induces p53-dependent cell death through facilitating HIPK2 phosphorylation of Ser(46).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Axin-1;Cellular tumor antigen p53;Homeodomain-interacting protein kinase 2	AXIN1;TP53;HIPK2	AXIN;P53;None
2846	ITGAV-ITGB3-THBS1 complex	Human	integrin complex	blood cell	P05106;P06756;P07996	3690;3685;7057	MI:0004-affinity chromatography technology	GO:0005515	protein binding	16.01	protein binding	2478219	The alpha(v)beta3 integrin on platelets, endothelial cells, and smooth muscle cells functions as an Arg-Gly-Asp (RGD)-dependent receptor for thrombospondin.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-3;Integrin alpha-V;Thrombospondin-1	ITGB3;ITGAV;THBS1	GP3A;MSK8 VNRA VTNR;TSP TSP1
2847	ING4 complex (ING4, JADE2, KAT7, MEAF6)	Human	ING4 complex (ING4, PHF15, HBO1, C1orf149)	HeLa S3 cells	O95251;Q9HAF1;Q9NQC1;Q9UNL4	11143;64769;23338;51147	MI:0004-affinity chromatography technology;MI:0069-mass spectrometry studies of complexes	GO:0000278;GO:0051726;GO:0001525	mitotic cell cycle;regulation of cell cycle;angiogenesis	10.03.01.01;10.03.01;41.05.16	mitotic cell cycle;mitotic cell cycle and cell cycle control;angiogenesis	16387653	ING4 associates with the HBO1 HAT required for normal progression through S phase and the majority of histone H4 acetylation in vivo. ING subunits are probably crucial for acetylation of chromatin substrates.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone acetyltransferase KAT7;Chromatin modification-related protein MEAF6;E3 ubiquitin-protein ligase Jade-2;Inhibitor of growth protein 4	KAT7;MEAF6;JADE2;ING4	HBO1 HBOa MYST2;C1orf149 CENP-28 EAF6;KIAA0239 PHF15;None
2848	ING4 complex (ING4, JADE3, KAT7, MEAF6)	Human	ING4 complex (ING4, PHF16, HBO1, C1orf149)	HeLa S3 cells	O95251;Q92613;Q9HAF1;Q9UNL4	11143;9767;64769;51147	MI:0004-affinity chromatography technology;MI:0069-mass spectrometry studies of complexes	GO:0000278;GO:0051726;GO:0001525	mitotic cell cycle;regulation of cell cycle;angiogenesis	10.03.01.01;10.03.01;41.05.16	mitotic cell cycle;mitotic cell cycle and cell cycle control;angiogenesis	16387653	ING4 associates with the HBO1 HAT required for normal progression through S phase and the majority of histone H4 acetylation in vivo. ING subunits are probably crucial for acetylation of chromatin substrates.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone acetyltransferase KAT7;Protein Jade-3;Chromatin modification-related protein MEAF6;Inhibitor of growth protein 4	KAT7;JADE3;MEAF6;ING4	HBO1 HBOa MYST2;KIAA0215, PHF16;C1orf149 CENP-28 EAF6;None
2849	ITGAV-ITGB3-NOV complex	Human	integrin complex	None	P05106;P06756;P48745	3690;3685;4856	MI:0004-affinity chromatography technology	GO:0005515;GO:0007155	protein binding;cell adhesion	16.01;34.07	protein binding;cell adhesion	12902636	The C-terminal domain of NOV is involved in the interaction with integrins.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-3;Integrin alpha-V;CCN family member 3	ITGB3;ITGAV;CCN3	GP3A;MSK8 VNRA VTNR;IGFBP9 NOV NOVH
2850	ITGA5-ITGB1-FN-1-NOV complex	Human	integrin complex	None	P02751;P05556;P08648;P48745	2335;3688;3678;4856	MI:0004-affinity chromatography technology;MI:0019-coimmunoprecipitation	GO:0005515;GO:0007155	protein binding;cell adhesion	16.01;34.07	protein binding;cell adhesion	12902636	The involvement of alpha5-beta1 in the process of endothelial cell adhesion to NOV was mediated by fibronectin.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Fibronectin;Integrin beta-1;Integrin alpha-5;CCN family member 3	FN1;ITGB1;ITGA5;CCN3	FN;FNRB, MDF2, MSK12;FNRA;IGFBP9 NOV NOVH
2851	ING2 complex	Human	None	HeLa S3 cells	O75446;P29374;Q09028;Q13547;Q16576;Q4LE39;Q5PSV4;Q92769;Q96ST3;Q9H0E3;Q9H160;Q9H7L9;Q9HCU9	8819;5926;5928;3065;5931;51742;84312;3066;25942;79595;3622;64426;25855	MI:0004-affinity chromatography technology;MI:0069-mass spectrometry studies of complexes	GO:0006265;GO:0000278;GO:0051726;GO:0006473;GO:0006476;GO:0006915;GO:0001525;GO:0051276;GO:0005634	DNA topological change;mitotic cell cycle;regulation of cell cycle;protein acetylation;protein deacetylation;apoptotic process;angiogenesis;chromosome organization;nucleus	10.01.09.05;10.03.01.01;10.03.01;14.07.04;40.10.02;41.05.16;42.10.03;70.10	DNA conformation modification (e.g. chromatin);mitotic cell cycle;mitotic cell cycle and cell cycle control;modification by acetylation, deacetylation;apoptosis (type I programmed cell death);angiogenesis;organization of chromosome structure;nucleus	16387653	ING2 is in an HDAC complex similar to ING1.ING subunits are probably crucial for acetylation of chromatin substrates.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone deacetylase complex subunit SAP30;AT-rich interactive domain-containing protein 4A;Histone-binding protein RBBP4;Histone deacetylase 1;Histone-binding protein RBBP7;AT-rich interactive domain-containing protein 4B;Breast cancer metastasis-suppressor 1-like protein;Histone deacetylase 2;Paired amphipathic helix protein Sin3a;Histone deacetylase complex subunit SAP130;Inhibitor of growth protein 2;Sin3 histone deacetylase corepressor complex component SDS3;Breast cancer metastasis-suppressor 1	SAP30;ARID4A;RBBP4;HDAC1;RBBP7;ARID4B;BRMS1L;HDAC2;SIN3A;SAP130;ING2;SUDS3;BRMS1	None;RBBP1 RBP1;RBAP48;RPD3L1;RBAP46;BRCAA1 RBBP1L1 RBP1L1 SAP180;None;None;None;None;ING1L;SAP45 SDS3;None
2852	Brg1-based SWI/SNF complex	Human	Brg1-based SWI/SNF chromatin remodeling complex	HeLa S3 cells	O96019;Q12824;Q8TAQ2;Q92922	86;6598;6601;6599	MI:0047-far western blotting	GO:0006265;GO:0000278;GO:0051726;GO:2001141;GO:0006355	DNA topological change;mitotic cell cycle;regulation of cell cycle;regulation of RNA biosynthetic process;regulation of DNA-templated transcription	10.01.09.05;10.03.01.01;10.03.01;11.02.03.04	DNA conformation modification (e.g. chromatin);mitotic cell cycle;mitotic cell cycle and cell cycle control;transcriptional control	16387653	A subset of ING1-mSin3 HDAC complex was also shown to be associated with Brg1-based SWI/SNF chromatin remodelingcomplexes.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Actin-like protein 6A;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1;SWI/SNF complex subunit SMARCC2;SWI/SNF complex subunit SMARCC1	ACTL6A;SMARCB1;SMARCC2;SMARCC1	BAF53 BAF53A INO80K;BAF47, INI1, SNF5L1;BAF170;BAF155
2853	ITGA5-ITGB1-CAL4A3 complex	Human	integrin complex	None	P05556;P08648;P39060	3688;3678;80781	MI:0004-affinity chromatography technology;MI:0019-coimmunoprecipitation	GO:0006469;GO:0019210	negative regulation of protein kinase activity;kinase inhibitor activity	18.02.01.02.05	kinase inhibitior	12682293	Endostatin binding to alpha5-beta1 integrin leads to the inhibition of focal adhesion kinase/c-Raf/MEK1/2/p38/ERK1 mitogen-activated protein kinase pathway, with no effect on phosphatidylinositol 3-kinase/Akt/mTOR/4E-BP1 and Cap-dependent translation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-1;Integrin alpha-5;Collagen alpha-1(XVIII) chain	ITGB1;ITGA5;COL18A1	FNRB, MDF2, MSK12;FNRA;None
2856	NuA4/Tip60 HAT complex	Human	None	HeLa S3 cells	O96019;Q92993;Q96L91;Q9H0E9;Q9H2F5;Q9NPF5;Q9NXR8;Q9UBU8;Q9Y265;Q9Y4A5	86;10524;57634;10902;80314;55929;54556;10933;8607;8295	MI:0047-far western blotting	GO:0051276;GO:0006281;GO:0006265;GO:0000278;GO:0051726;GO:0003677;GO:0006915;GO:0005634;GO:0016573	chromosome organization;DNA repair;DNA topological change;mitotic cell cycle;regulation of cell cycle;DNA binding;apoptotic process;nucleus;histone acetylation	42.10.03;10.01.05.01;10.01.09.05;10.03.01.01;10.03.01;16.03.01;40.10.02;70.10	organization of chromosome structure;DNA repair;DNA conformation modification (e.g. chromatin);mitotic cell cycle;mitotic cell cycle and cell cycle control;DNA binding;apoptosis (type I programmed cell death);nucleus	16387653	The NuA4 histone acetyltransferase (HAT) multisubunit complex is responsible for acetylation of histone H4 and H2A N-terminal tails in yeast. The NuA4/Tip60 HAT complex is highly conserved in eukaryotes playing primary roles in transcription, cellular response to DNA damage, and cell cycle control. ING subunits are probably crucial for acetylation of chromatin substrates.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Actin-like protein 6A;Histone acetyltransferase KAT5;E1A-binding protein p400;Bromodomain-containing protein 8;Enhancer of polycomb homolog 1;DNA methyltransferase 1-associated protein 1;Inhibitor of growth protein 3;Mortality factor 4-like protein 1;RuvB-like 1;Transformation/transcription domain-associated protein	ACTL6A;KAT5;EP400;BRD8;EPC1;DMAP1;ING3;MORF4L1;RUVBL1;TRRAP	BAF53 BAF53A INO80K;HTATIP, TIP60;CAGH32 KIAA1498 KIAA1818 TNRC12;SMAP, SMAP2;None;KIAA1425;None;MRG15;INO80H NMP238 TIP49 TIP49A;PAF400
2857	NuA4/Tip60 HAT complex	Human	ING3-TIP60 complex	HeLa S3 cells	O95619;O96019;Q52LR7;Q92993;Q96L91;Q9H0E9;Q9H2F5;Q9HAF1;Q9NPF5;Q9NXR8;Q9UBU8;Q9Y230;Q9Y265;Q9Y4A5	8089;86;26122;10524;57634;10902;80314;64769;55929;54556;10933;10856;8607;8295	MI:0047-far western blotting	GO:0051276;GO:0006281;GO:0006265;GO:0000278;GO:0051726;GO:0003677;GO:0006915;GO:0005634;GO:0016573	chromosome organization;DNA repair;DNA topological change;mitotic cell cycle;regulation of cell cycle;DNA binding;apoptotic process;nucleus;histone acetylation	42.10.03;10.01.05.01;10.01.09.05;10.03.01.01;10.03.01;16.03.01;40.10.02;70.10	organization of chromosome structure;DNA repair;DNA conformation modification (e.g. chromatin);mitotic cell cycle;mitotic cell cycle and cell cycle control;DNA binding;apoptosis (type I programmed cell death);nucleus	16387653	Human INGs could be divided in three groups, ING1/2, ING3, and ING4/5, suggesting three distinct types of association to protein complexes. The majority of ING3 is associated with the hNuA4/Tip60 HAT complex	None	An actin component which was not exactly defined was also found.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	YEATS domain-containing protein 4;Actin-like protein 6A;Enhancer of polycomb homolog 2;Histone acetyltransferase KAT5;E1A-binding protein p400;Bromodomain-containing protein 8;Enhancer of polycomb homolog 1;Chromatin modification-related protein MEAF6;DNA methyltransferase 1-associated protein 1;Inhibitor of growth protein 3;Mortality factor 4-like protein 1;RuvB-like 2;RuvB-like 1;Transformation/transcription domain-associated protein	YEATS4;ACTL6A;EPC2;KAT5;EP400;BRD8;EPC1;MEAF6;DMAP1;ING3;MORF4L1;RUVBL2;RUVBL1;TRRAP	GAS41;BAF53 BAF53A INO80K;None;HTATIP, TIP60;CAGH32 KIAA1498 KIAA1818 TNRC12;SMAP, SMAP2;None;C1orf149 CENP-28 EAF6;KIAA1425;None;MRG15;INO80J TIP48 TIP49B;INO80H NMP238 TIP49 TIP49A;PAF400
2858	ING5 complex (ING5, JADE1, KAT7, MEAF6)	Human	ING5 complex (ING5, PHF17, HBO1, C1orf149)	HeLa S3 cells	O95251;Q6IE81;Q8WYH8;Q9HAF1	11143;79960;84289;64769	MI:0047-far western blotting;MI:0069-mass spectrometry studies of complexes	GO:0000278;GO:0051726;GO:0006915	mitotic cell cycle;regulation of cell cycle;apoptotic process	10.03.01.01;10.03.01;40.10.02	mitotic cell cycle;mitotic cell cycle and cell cycle control;apoptosis (type I programmed cell death)	16387653	Members of the ING family of tumor suppressors regulatecell cycle progression, apoptosis, and DNA repair. HBO1-ING5 association is independent of MOZ/MORF and is responsible for the H4-specific HAT activity in purified ING5.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone acetyltransferase KAT7;Protein Jade-1;Inhibitor of growth protein 5;Chromatin modification-related protein MEAF6	KAT7;JADE1;ING5;MEAF6	HBO1 HBOa MYST2;KIAA1807 PHF17;None;C1orf149 CENP-28 EAF6
2859	ING5 (BRPF1, MOZ, MORF) complex	Human	ING5 (BRPF1, KAT6A, KAT6B) complex	HeLa S3 cells	P55201;Q8WYB5;Q8WYH8;Q92794;Q9HAF1	7862;23522;84289;7994;64769	MI:0047-far western blotting	GO:0000278;GO:0051726;GO:0006915	mitotic cell cycle;regulation of cell cycle;apoptotic process	10.03.01.01;10.03.01;40.10.02	mitotic cell cycle;mitotic cell cycle and cell cycle control;apoptosis (type I programmed cell death)	16387653	ING5 HAT complexes interact with the MCM helicase and are essential for DNA replication to occur during S phase.ING subunits are probably crucial for acetylation of chromatin substrates. ING5 fractionates with two distinct complexes containing HBO1 or nucleosomal H3-specific MOZ/MORF HATs. Both MOZ/MORF-ING5 and HBO1-ING5 HAT complexes are important for DNA replication.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Peregrin;Histone acetyltransferase KAT6B;Inhibitor of growth protein 5;Histone acetyltransferase KAT6A;Chromatin modification-related protein MEAF6	BRPF1;KAT6B;ING5;KAT6A;MEAF6	BR140;KIAA0383 MORF MOZ2 MYST4;None;MOZ MYST3 RUNXBP2 ZNF220;C1orf149 CENP-28 EAF6
2861	DSIF complex (DRB sensitivity-inducing factor complex)	Human	None	HeLa cell nuclear extracts	O00267;P63272	6829;6827	MI:0226-ion exchange chromatography	GO:0006354;GO:0045892;GO:0051098;GO:0005515;GO:0005634	DNA-templated transcription elongation;negative regulation of DNA-templated transcription;regulation of binding;protein binding;nucleus	11.02.03.01.04;11.02.03.04.03;18.01.07;16.01;70.10	transcription elongation;transcription repression;regulation by binding / dissociation;protein binding;nucleus	9450929	The DSIF complex regulates RNA polymerase II processivity.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Transcription elongation factor SPT5;Transcription elongation factor SPT4	SUPT5H;SUPT4H1	SPT5, SPT5H;SPT4H, SUPT4H
2863	Serine-palmitoyltransferase (SPTLC1, SPTLC3) complex	Human	LCB1-SPTLC2L complex; SPT complex	Hek293 cells; HepG2 cells	O15269;Q9NUV7	10558;55304	MI:0400-affinity technology	GO:0002178;GO:0016409;GO:0005783;GO:0030148	palmitoyltransferase complex;palmitoyltransferase activity;endoplasmic reticulum;sphingolipid biosynthetic process	70.07	endoplasmic reticulum	17023427	Serine-palmitoyltransferase (SPT) catalyzes the rate-limiting step of the de novo synthesis of sphingolipids.	None	SPTLC3 overexpression increases SPT activity 2- to 3-fold. SPTLC3 can be considered as an isoform of SPTLC2.	Homo sapiens (Human);Homo sapiens (Human)	Serine palmitoyltransferase 1;Serine palmitoyltransferase 3	SPTLC1;SPTLC3	LCB1;C20orf38 SPTLC2L
2872	ITGA2b-ITGB3-CD9-GP1b-CD47 complex	Human	integrin complex	blood cell	P05106;P07359;P08514;P21926;Q08722	3690;2811;3674;928;961	MI:0019-coimmunoprecipitation	GO:0007155;GO:0005886	cell adhesion;plasma membrane	34.07;70.02	cell adhesion;eukaryotic plasma membrane / membrane attached	10429193	The isolation of this complex was independent of platelet activation, although a twofold increase in the quantity of CD9 complex was seen after platelet activation by alpha-thrombin in the presence of CaCl2 compared with that present in EDTA.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-3;Platelet glycoprotein Ib alpha chain;Integrin alpha-IIb;CD9 antigen;Leukocyte surface antigen CD47	ITGB3;GP1BA;ITGA2B;CD9;CD47	GP3A;None;GP2B ITGAB;MIC3, TSPAN29;MER6
2873	P-TEFb-7SKRNA-HEXIM1 complex	Human	None	HeLa cells	O60563;O94992;P50750	904;10614;1025	MI:0007-anti tag coimmunoprecipitation;MI:0071-molecular sieving	GO:0006354;GO:2001141;GO:0006355;GO:0005634	DNA-templated transcription elongation;regulation of RNA biosynthetic process;regulation of DNA-templated transcription;nucleus	11.02.03.01.04;11.02.03.04;70.10	transcription elongation;transcriptional control;nucleus	12832472	7SK RNA is required for HEXIM1 to associate with P-TEFb complex. This allowes HEXIM1 to inhibit transcription. P-TEFb dissociates from HEXIM1 and 7SK in cells undergoing stress response, increasing the level of active P-TEFb for stress-induced transcription. (PMID: 14580347)	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cyclin-T1;Protein HEXIM1;Cyclin-dependent kinase 9	CCNT1;HEXIM1;CDK9	None;CLP1, EDG1, HIS1, MAQ1;CDC2L4 TAK
2875	BRD4-P-TEFb complex	Human	CCNT1-CDK9-BRD4 complex	HeLa cells	O60563;O60885;P50750	904;23476;1025	MI:0006-anti bait coimmunoprecipitation;MI:0007-anti tag coimmunoprecipitation;MI:0402-chromatin immunoprecipitation assay	GO:0006354;GO:0045893;GO:0005634;GO:0070816	DNA-templated transcription elongation;positive regulation of DNA-templated transcription;nucleus;phosphorylation of RNA polymerase II C-terminal domain	11.02.03.01.04;11.02.03.04.01;70.10	transcription elongation;transcription activation;nucleus	16109376	BRD4 interacts with p-TEFb through its bromodomain. Recruitment of P-TEFb to a promoter was dependent on Brd4 and was enhanced by an increase in chromatin acetylation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cyclin-T1;Bromodomain-containing protein 4;Cyclin-dependent kinase 9	CCNT1;BRD4;CDK9	None;HUNK1;CDC2L4 TAK
2879	CD20-LCK-FYN-p75/80 complex	Human	None	MOLT-4 cells	P06239;P06241;P11836	3932;2534;931	MI:0019-coimmunoprecipitation	GO:0023052	signaling	30.01	cellular signalling	7545683	Lck accounted for most of the PTK activity in the CD20 complex.	None	At the time of annotation, the identity of the additional member p75/80 of the protein complex was not known.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Tyrosine-protein kinase Lck;Tyrosine-protein kinase Fyn;B-lymphocyte antigen CD20	LCK;FYN;MS4A1	None;None;CD20
2880	Ubiquitin E3 ligase (FBXW11, SKP1, CUL1)	Human	Ubiquitin E3 ligase (TRCP2, SKP2, CUL1)	HeLa cells; 293T cells	P63208;Q13616;Q9UKB1	6500;8454;23291	MI:0019-coimmunoprecipitation	GO:0006511;GO:0016567;GO:0006468;GO:0000087	ubiquitin-dependent protein catabolic process;protein ubiquitination;protein phosphorylation;mitotic M phase	14.13.01.01;14.07.05;14.07.03	proteasomal degradation (ubiquitin/proteasomal pathway);modification by ubiquitination, deubiquitination;modification by phosphorylation, dephosphorylation, autophosphorylation	15070733	Ubiquitin E3 ligases covalently attach ubiquitin to a lysine residue on a target protein. Polyubiquitination marks proteins for degradation by the proteasome. Human somatic Wee1 (Wee1A) is down-regulated both by protein phosphorylation and degradation. The beta-transducin repeat-containing protein 1/2 (beta-TrCP1/2) F-box protein-containing SKP1/Cul1/F-box protein (SCF) complex (SCF(beta-TrCP1/2)) as an E3 ubiquitin ligase for Wee1A ubiquitination has been identified.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	S-phase kinase-associated protein 1;Cullin-1;F-box/WD repeat-containing protein 11	SKP1;CUL1;FBXW11	EMC19 OCP2 SKP1A TCEB1L;None;BTRCP2 FBW1B FBXW1B KIAA0696
2881	Ubiquitin E3 ligase (BTRC, CUL1, RBX1, SKP1)	Human	None	HeLa cells; 293T cells	P62877;P63208;Q13616;Q9Y297	9978;6500;8454;8945	MI:0019-coimmunoprecipitation	GO:0016567;GO:0006468;GO:0006511;GO:0000087	protein ubiquitination;protein phosphorylation;ubiquitin-dependent protein catabolic process;mitotic M phase	14.07.05;14.07.03;14.13.01.01	modification by ubiquitination, deubiquitination;modification by phosphorylation, dephosphorylation, autophosphorylation;proteasomal degradation (ubiquitin/proteasomal pathway)	15070733	Ubiquitin E3 ligases covalently attach ubiquitin to a lysine residue on a target protein. Polyubiquitination marks proteins for degradation by the proteasome. Human somatic Wee1 (Wee1A) is down-regulated both by protein phosphorylation and degradation. The beta-transducin repeat-containing protein 1/2 (beta-TrCP1/2) F-box protein-containing SKP1/Cul1/F-box protein (SCF) complex (SCF(beta-TrCP1/2)) as an E3 ubiquitin ligase for Wee1A ubiquitination has been identified.	None	Hemagglutinin (HA-)tagged F-box proteins were also found in this study (not further specified).	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase RBX1;S-phase kinase-associated protein 1;Cullin-1;F-box/WD repeat-containing protein 1A	RBX1;SKP1;CUL1;BTRC	RNF75 ROC1;EMC19 OCP2 SKP1A TCEB1L;None;BTRCP FBW1A FBXW1A
2882	ITGA5-ITGB3-COL6A3 complex	Human	integrin complex	None	P05106;P08648;P12111	3690;3678;1293	MI:0004-affinity chromatography technology	GO:0005515;GO:0007155;GO:0005886;GO:0031012	protein binding;cell adhesion;plasma membrane;extracellular matrix	16.01;34.07;70.02;70.27.01	protein binding;cell adhesion;eukaryotic plasma membrane / membrane attached;extracellular matrix component	8387021	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-3;Integrin alpha-5;Collagen alpha-3(VI) chain	ITGB3;ITGA5;COL6A3	GP3A;FNRA;None
2884	Respiratory chain complex I (early intermediate NDUFAF1 assembly), mitochondrial	Human	NADH:ubiquinone oxidoreductase (EC 1.6.5.3) incomplete intermediate	HEK-293T cells; human primary fibroblasts	O75251;O75489;O95139;P03886;P56556;Q16795;Q9Y375	374291;4722;4712;4535;4700;4704;51103	MI:0019-coimmunoprecipitation;MI:0276-blue native page	GO:0022904;GO:0005743;GO:0006119;GO:0009060;GO:1902600;GO:0065003	respiratory electron transport chain;mitochondrial inner membrane;oxidative phosphorylation;aerobic respiration;proton transmembrane transport;protein-containing complex assembly	02.11.07;20.01.15;70.16.05;02.13.03	regulation of electron transport and membrane-associated energy conservation;electron transport;mitochondrial inner membrane;aerobic respiration	17557076	Complex I is the first multiprotein complex of the OXPHOS system and participates in the formation of a proton gradient across the inner mitochondrial membrane coupled to transfer of electrons from NADH to ubiquinone.NDUFAF1 is a crucial component in the early assembly of complex I but not of the mature holoenzyme.	Complex I is involved e.g. in mitochondrial diseases, cardioencephalomyopathy (gene CIA30), or deficiency in fibroblasts.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial;NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6;NADH-ubiquinone oxidoreductase chain 1;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial;Complex I intermediate-associated protein 30, mitochondrial	NDUFS7;NDUFS3;NDUFB6;MT-ND1;NDUFA6;NDUFA9;NDUFAF1	None;None;None;MTND1 NADH1 ND1;LYRM6 NADHB14;NDUFS2L;CIA30
2885	ITGAV-ITGB1-SPP1 complex	Human	integrin complex	None	P05556;P06756;P10451	3688;3685;6696	MI:0004-affinity chromatography technology	GO:0005515;GO:0007155;GO:0005886	protein binding;cell adhesion;plasma membrane	16.01;34.07;70.02	protein binding;cell adhesion;eukaryotic plasma membrane / membrane attached	7532190	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-1;Integrin alpha-V;Osteopontin	ITGB1;ITGAV;SPP1	FNRB, MDF2, MSK12;MSK8 VNRA VTNR;BNSP OPN
2886	Respiratory chain complex I (incomplete intermediate ND1, ND2, ND3, CIA30 assembly), mitochondrial	Human	NADH:ubiquinone oxidoreductase (EC 1.6.5.3) incomplete intermediate	HEK-293T cells; human primary fibroblasts	P03886;P03891;P03897;Q9Y375	4535;4536;4537;51103	MI:0019-coimmunoprecipitation	GO:0022904;GO:0005743;GO:0006119;GO:0009060;GO:1902600;GO:0065003	respiratory electron transport chain;mitochondrial inner membrane;oxidative phosphorylation;aerobic respiration;proton transmembrane transport;protein-containing complex assembly	02.11.07;20.01.15;70.16.05;02.13.03	regulation of electron transport and membrane-associated energy conservation;electron transport;mitochondrial inner membrane;aerobic respiration	17557076	Complex I is the first multiprotein complex of the OXPHOS system and participates in the formation of a proton gradient across the inner mitochondrial membrane coupled to transfer of electrons from NADH to ubiquinone.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	NADH-ubiquinone oxidoreductase chain 1;NADH-ubiquinone oxidoreductase chain 2;NADH-ubiquinone oxidoreductase chain 3;Complex I intermediate-associated protein 30, mitochondrial	MT-ND1;MT-ND2;MT-ND3;NDUFAF1	MTND1 NADH1 ND1;MTND2 NADH2 ND2;MTND3 NADH3 ND3;CIA30
2890	RBPJ-NOTCH1-MAML1 complex	Human	Notch1-fraction 30 complex; CSL-NotchIC-Mastermind complex	T-cell leukemia cell line	P46531;Q06330;Q92585	4851;3516;9794	MI:0006-anti bait coimmunoprecipitation;MI:0071-molecular sieving	GO:0045893;GO:0003677;GO:0007219;GO:0005634	positive regulation of DNA-templated transcription;DNA binding;Notch signaling pathway;nucleus	11.02.03.04.01;16.03.01;30.05.02.14;70.10	transcription activation;DNA binding;Notch-receptor signalling pathway;nucleus	11997524	Complex formation is required for neoplastic transformation by Notch. MAML1 promotes association between NotchIC (intracellular domain of Notch) and RBPSUH (CSL). NotchIC binding to CSL displaces corepressors from CSL, leading to the binding of the transcriptional coactivator MAML1 to the complex.	Notch1 is involved in human cancer.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Neurogenic locus notch homolog protein 1;Recombining binding protein suppressor of hairless;Mastermind-like protein 1	NOTCH1;RBPJ;MAML1	TAN1;IGKJRB IGKJRB1 RBPJK RBPSUH;KIAA0200
2892	BCR-ABL (p185 fusion protein)-GRB2 complex	Human	None	None	P62993;Q13745	2885;None	MI:0006-anti bait coimmunoprecipitation;MI:0096-pull down	GO:0007186	G protein-coupled receptor signaling pathway	30.05.02.24	G-protein coupled receptor signalling pathway	8112292	It was shown that Grb2 binds to the Tyr177 autophosphorylation site on Bcr-Abl.	Chimeric bcr-abl oncogene is involved in Philadelphia chromosome positive (Ph+) chronic myelogenous leukemia (CML) and acute lymphoblastic leukemia (Ph+ ALL).	None	Homo sapiens (Human);Homo sapiens (Human)	Growth factor receptor-bound protein 2;Acute lymphocytic leukemia	GRB2;None	ASH;None
2893	BCR-ABL (p210 fusion protein)-GRB2-SOS1 complex	Human	None	None	A1Z199;P62993;Q07889	None;2885;6654	MI:0006-anti bait coimmunoprecipitation	GO:0023052;GO:0007186	signaling;G protein-coupled receptor signaling pathway	30.01;30.05.02.24	cellular signalling;G-protein coupled receptor signalling pathway	8112292	It was shown that Grb2 binds to the Tyr177 autophosphorylation site on Bcr-Abl.	Chimeric bcr-abl oncogene is involved in Philadelphia chromosome positive (Ph+) chronic myelogenous leukemia (CML) and acute lymphoblastic leukemia (Ph+ ALL).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	BCR/ABL p210 fusion protein;Growth factor receptor-bound protein 2;Son of sevenless homolog 1	BCR/ABL fusion;GRB2;SOS1	None;ASH;None
2895	SHC-GRB2 complex	Human	None	None	P29353;P62993	6464;2885	MI:0006-anti bait coimmunoprecipitation	GO:0023052	signaling	30.01	cellular signalling	8112292	Bcr-Abl proteins induce the formation of a complex between tyrosine phosphorylated Shc and Grb2. Co-precipitation analysed in R1-p185, R1-p210 and in Ph(+) leucemic cell lines. No co-precipitation seen in parental R1 cells.	Chimeric bcr-abl oncogene is involved in Philadelphia chromosome positive (Ph+) chronic myelogenous leukemia (CML) and acute lymphoblastic leukemia (Ph+ ALL).	None	Homo sapiens (Human);Homo sapiens (Human)	SHC-transforming protein 1;Growth factor receptor-bound protein 2	SHC1;GRB2	SHC SHCA;ASH
2896	ITGA2B-ITGB3-CD47-FAK complex	Human	None	blood cell	P05106;P08514;Q05397;Q08722	3690;3674;5747;961	MI:0004-affinity chromatography technology;MI:0019-coimmunoprecipitation	GO:0005515;GO:0007155	protein binding;cell adhesion	16.01;34.07	protein binding;cell adhesion	9169439	Activation of platelets with the agonist peptide 4N1K results in the association of FAK with the IAP-alpha-IIb-beta3 complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-3;Integrin alpha-IIb;Focal adhesion kinase 1;Leukocyte surface antigen CD47	ITGB3;ITGA2B;PTK2;CD47	GP3A;GP2B ITGAB;FAK, FAK1;MER6
2898	Respiratory chain complex I (intermediate I/200kD and III/250kD), mitochondrial	Human	NADH:ubiquinone oxidoreductase (EC 1.6.5.3) subcomplex I and III	primary skin fibroblasts; muscle mitochondria from patients	O75306;O75489;Q16795	4720;4722;4704	MI:0047-far western blotting;MI:0276-blue native page	GO:0022904;GO:0005743;GO:0006119;GO:0009060;GO:1902600;GO:0065003	respiratory electron transport chain;mitochondrial inner membrane;oxidative phosphorylation;aerobic respiration;proton transmembrane transport;protein-containing complex assembly	02.11.07;20.01.15;70.16.05;02.13.03	regulation of electron transport and membrane-associated energy conservation;electron transport;mitochondrial inner membrane;aerobic respiration	12941961	Complex I is the first multiprotein complex of the OXPHOS system and participates in the formation of a proton gradient across the inner mitochondrial membrane coupled to transfer of electrons from NADH to ubiquinone.Intermediate I and III show the same components (therefore annotated as one entry only) but different molecular weights.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial;NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial	NDUFS2;NDUFS3;NDUFA9	None;None;NDUFS2L
2901	Respiratory chain complex I (intermediate IV/310kD), mitochondrial	Human	NADH:ubiquinone oxidoreductase (EC 1.6.5.3) subcomplex IV	primary skin fibroblasts; muscle mitochondria from patients	O75306;O75489;P03886;Q16795	4720;4722;4535;4704	MI:0047-far western blotting;MI:0276-blue native page	GO:0022904;GO:0005743;GO:0006119;GO:0009060;GO:1902600;GO:0065003	respiratory electron transport chain;mitochondrial inner membrane;oxidative phosphorylation;aerobic respiration;proton transmembrane transport;protein-containing complex assembly	02.11.07;20.01.15;70.16.05;02.13.03	regulation of electron transport and membrane-associated energy conservation;electron transport;mitochondrial inner membrane;aerobic respiration	12941961	Complex I is the first multiprotein complex of the OXPHOS system and participates in the formation of a proton gradient across the inner mitochondrial membrane coupled to transfer of electrons from NADH to ubiquinone.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial;NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial;NADH-ubiquinone oxidoreductase chain 1;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial	NDUFS2;NDUFS3;MT-ND1;NDUFA9	None;None;MTND1 NADH1 ND1;NDUFS2L
2903	Respiratory chain complex I (intermediate V/380kD and VI/480kD), mitochondrial	Human	NADH:ubiquinone oxidoreductase (EC 1.6.5.3) subcomplex V and VI	primary skin fibroblasts; muscle mitochondria from patients	O43678;O75306;O75489;P03886;Q16795	4695;4720;4722;4535;4704	MI:0047-far western blotting;MI:0276-blue native page	GO:0022904;GO:0005743;GO:0006119;GO:0009060;GO:1902600;GO:0065003	respiratory electron transport chain;mitochondrial inner membrane;oxidative phosphorylation;aerobic respiration;proton transmembrane transport;protein-containing complex assembly	02.11.07;20.01.15;70.16.05;02.13.03	regulation of electron transport and membrane-associated energy conservation;electron transport;mitochondrial inner membrane;aerobic respiration	12941961	Complex I is the first multiprotein complex of the OXPHOS system and participates in the formation of a proton gradient across the inner mitochondrial membrane coupled to transfer of electrons from NADH to ubiquinone.Intermediate V and VI show the same components (therefore annotated as one entry only) but different molecular weights.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2;NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial;NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial;NADH-ubiquinone oxidoreductase chain 1;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial	NDUFA2;NDUFS2;NDUFS3;MT-ND1;NDUFA9	None;None;None;MTND1 NADH1 ND1;NDUFS2L
2904	Respiratory chain complex I (intermediate VII/650kD), mitochondrial	Human	NADH:ubiquinone oxidoreductase (EC 1.6.5.3) subcomplex VII	primary skin fibroblasts; muscle mitochondria from patients	O43181;O43678;O43920;O75251;O75306;O75489;P03886;P19404;P56556;Q16795	4724;4695;4725;374291;4720;4722;4535;4729;4700;4704	MI:0047-far western blotting;MI:0276-blue native page	GO:0022904;GO:0005743;GO:0006119;GO:0009060;GO:1902600;GO:0065003	respiratory electron transport chain;mitochondrial inner membrane;oxidative phosphorylation;aerobic respiration;proton transmembrane transport;protein-containing complex assembly	02.11.07;20.01.15;70.16.05;02.13.03	regulation of electron transport and membrane-associated energy conservation;electron transport;mitochondrial inner membrane;aerobic respiration	12941961	Complex I is the first multiprotein complex of the OXPHOS system and participates in the formation of a proton gradient across the inner mitochondrial membrane coupled to transfer of electrons from NADH to ubiquinone.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2;NADH dehydrogenase [ubiquinone] iron-sulfur protein 5;NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial;NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial;NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial;NADH-ubiquinone oxidoreductase chain 1;NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial	NDUFS4;NDUFA2;NDUFS5;NDUFS7;NDUFS2;NDUFS3;MT-ND1;NDUFV2;NDUFA6;NDUFA9	None;None;None;None;None;None;MTND1 NADH1 ND1;None;LYRM6 NADHB14;NDUFS2L
2905	Respiratory chain complex I (intermediate), mitochondrial	Human	NADH:ubiquinone oxidoreductase (EC 1.6.5.3)	primary skin fibroblasts; muscle mitochondria from patients	O43181;O43678;O43920;O75251;O75306;O75489;O95139;P03886;P19404;P56556;Q16795	4724;4695;4725;374291;4720;4722;4712;4535;4729;4700;4704	MI:0047-far western blotting;MI:0276-blue native page	GO:0022904;GO:0005743;GO:0006119;GO:0009060;GO:1902600;GO:0065003	respiratory electron transport chain;mitochondrial inner membrane;oxidative phosphorylation;aerobic respiration;proton transmembrane transport;protein-containing complex assembly	02.11.07;20.01.15;70.16.05;02.13.03	regulation of electron transport and membrane-associated energy conservation;electron transport;mitochondrial inner membrane;aerobic respiration	12941961	Complex I is the first multiprotein complex of the OXPHOS system and participates in the formation of a proton gradient across the inner mitochondrial membrane coupled to transfer of electrons from NADH to ubiquinone.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2;NADH dehydrogenase [ubiquinone] iron-sulfur protein 5;NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial;NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial;NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6;NADH-ubiquinone oxidoreductase chain 1;NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial	NDUFS4;NDUFA2;NDUFS5;NDUFS7;NDUFS2;NDUFS3;NDUFB6;MT-ND1;NDUFV2;NDUFA6;NDUFA9	None;None;None;None;None;None;None;MTND1 NADH1 ND1;None;LYRM6 NADHB14;NDUFS2L
2906	Respiratory chain complex I (intermediate II/230kD), mitochondrial	Human	NADH:ubiquinone oxidoreductase (EC 1.6.5.3) subcomplex II	primary skin fibroblasts; muscle mitochondria from patients	O43181;O75251;P19404	4724;374291;4729	MI:0047-far western blotting;MI:0276-blue native page	GO:0022904;GO:0005743;GO:0006119;GO:0009060;GO:1902600;GO:0065003	respiratory electron transport chain;mitochondrial inner membrane;oxidative phosphorylation;aerobic respiration;proton transmembrane transport;protein-containing complex assembly	02.11.07;20.01.15;70.16.05;02.13.03	regulation of electron transport and membrane-associated energy conservation;electron transport;mitochondrial inner membrane;aerobic respiration	12941961	Complex I is the first multiprotein complex of the OXPHOS system and participates in the formation of a proton gradient across the inner mitochondrial membrane coupled to transfer of electrons from NADH to ubiquinone.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial;NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial;NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	NDUFS4;NDUFS7;NDUFV2	None;None;None
2907	RBP-Jkappa-Notch1 complex	Human	None	None	P46531;Q06330	4851;3516	MI:0412-electrophoretic mobility supershift assay	GO:0045893;GO:0003677;GO:0007219;GO:0005634	positive regulation of DNA-templated transcription;DNA binding;Notch signaling pathway;nucleus	11.02.03.04.01;16.03.01;30.05.02.14;70.10	transcription activation;DNA binding;Notch-receptor signalling pathway;nucleus	12374742	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Neurogenic locus notch homolog protein 1;Recombining binding protein suppressor of hairless	NOTCH1;RBPJ	TAN1;IGKJRB IGKJRB1 RBPJK RBPSUH
2908	RBP-Jkappa-SHARP complex	Human	None	None	Q06330;Q96T58	3516;23013	MI:0412-electrophoretic mobility supershift assay	GO:0045892;GO:0003677;GO:0007219;GO:0005634	negative regulation of DNA-templated transcription;DNA binding;Notch signaling pathway;nucleus	11.02.03.04.03;16.03.01;30.05.02.14;70.10	transcription repression;DNA binding;Notch-receptor signalling pathway;nucleus	12374742	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Recombining binding protein suppressor of hairless;Msx2-interacting protein	RBPJ;SPEN	IGKJRB IGKJRB1 RBPJK RBPSUH;KIAA0929 MINT SHARP
2909	PLC-gamma-2-Syk-LAT-FcR-gamma complex	Human	None	platelet	O43561;P12314;P16885;P43405	27040;2209;5336;6850	MI:0096-pull down	GO:0007169;GO:0007596;GO:0048015	transmembrane receptor protein tyrosine kinase signaling pathway;blood coagulation;phosphatidylinositol-mediated signaling	30.05.01.12;36.25.16.09	transmembrane receptor protein tyrosine kinase signalling pathways;blood coagulation	10469124	Analyses done with different GST-PLC-gamma-2 fusion proteins from resting and CRP (collagen-related peptide) stimulated platelets.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Linker for activation of T-cells family member 1;High affinity immunoglobulin gamma Fc receptor I;1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2;Tyrosine-protein kinase SYK	LAT;FCGR1A;PLCG2;SYK	None;FCG1 FCGR1 IGFR1;None;None
2910	PLC-gamma-2-Lyn-FcR-gamma complex	Human	None	platelet	P07948;P12314;P16885	4067;2209;5336	MI:0019-coimmunoprecipitation	GO:0007169;GO:0007596;GO:0048015	transmembrane receptor protein tyrosine kinase signaling pathway;blood coagulation;phosphatidylinositol-mediated signaling	30.05.01.12;36.25.16.09	transmembrane receptor protein tyrosine kinase signalling pathways;blood coagulation	10469124	Analyses done with different GST-PLC-gamma-2 fusion proteins from resting and CRP (collagen-related peptide) stimulated platelets. PLC-gamma-2 associates in vivo with Lyn and FcR gamma chain. The identity of Lyn was confirmed by sequential immunoprecipitation after the kinase assay.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Tyrosine-protein kinase Lyn;High affinity immunoglobulin gamma Fc receptor I;1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	LYN;FCGR1A;PLCG2	JTK8;FCG1 FCGR1 IGFR1;None
2911	SMRT-SKIP-CBF1 complex	Human	None	None	Q06330;Q13573;Q9Y618	3516;22938;9612	MI:0428-imaging technique	GO:2001141;GO:0006355;GO:0006886;GO:0006605;GO:0015031;GO:0007219;GO:0005634	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;intracellular protein transport;protein targeting;protein transport;Notch signaling pathway;nucleus	11.02.03.04;14.04;20.01.10;30.05.02.14;70.10	transcriptional control;protein targeting, sorting and translocation;protein transport;Notch-receptor signalling pathway;nucleus	11509665	CIR seems to tether SKIP to SMRT.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Recombining binding protein suppressor of hairless;SNW domain-containing protein 1;Nuclear receptor corepressor 2	RBPJ;SNW1;NCOR2	IGKJRB IGKJRB1 RBPJK RBPSUH;SKIIP SKIP;CTG26
2912	PLC-gamma-2-SLP-76 complex	Human	None	platelet	P16885;Q13094	5336;3937	MI:0019-coimmunoprecipitation	GO:0007169;GO:0007596;GO:0048015	transmembrane receptor protein tyrosine kinase signaling pathway;blood coagulation;phosphatidylinositol-mediated signaling	30.05.01.12;36.25.16.09	transmembrane receptor protein tyrosine kinase signalling pathways;blood coagulation	10469124	Analyses done with  GST-PLC-gamma-2SH2(C) fusion protein from resting and CRP (collagen-related peptide) stimulated platelets. PLC-gamma-2 associates directly with SLP-76 and LAT.	None	None	Homo sapiens (Human);Homo sapiens (Human)	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2;Lymphocyte cytosolic protein 2	PLCG2;LCP2	None;None
2913	PLC-gamma-2-LAT complex	Human	None	platelet	O43561;P16885	27040;5336	MI:0019-coimmunoprecipitation	GO:0007169;GO:0007596;GO:0048015	transmembrane receptor protein tyrosine kinase signaling pathway;blood coagulation;phosphatidylinositol-mediated signaling	30.05.01.12;36.25.16.09	transmembrane receptor protein tyrosine kinase signalling pathways;blood coagulation	10469124	Analyses done with  GST-PLC-gamma-2SH2(C) fusion protein from resting and CRP (collagen-related peptide) stimulated platelets. PLC-gamma-2 associates directly with SLP-76 and LAT.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Linker for activation of T-cells family member 1;1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	LAT;PLCG2	None;None
2914	Respiratory chain complex I (beta subunit), mitochondrial	Human	NADH:ubiquinone oxidoreductase (EC 1.6.5.3) beta subunit	HEK 293 cells; 143B osteosarcoma cells	O00483;O14561;O43674;O43676;O75438;O95139;O95168;O95169;O95178;O95298;O96000;P03905;P03915;P17568;Q9NX14;Q9Y6M9	4697;4706;4711;4709;4707;4712;4710;4714;4708;4718;4716;4538;4540;4713;54539;4715	MI:0047-far western blotting;MI:0276-blue native page	GO:0022904;GO:0005743;GO:0006119;GO:0009060;GO:1902600;GO:0065003	respiratory electron transport chain;mitochondrial inner membrane;oxidative phosphorylation;aerobic respiration;proton transmembrane transport;protein-containing complex assembly	02.11.07;20.01.15;70.16.05;02.13.03	regulation of electron transport and membrane-associated energy conservation;electron transport;mitochondrial inner membrane;aerobic respiration	15317750	Complex I couples the transfer of two electrons from NADH to ubiquinone to the translocation of four protons across the mitochondrial inner membrane. Complex I is an L-shaped molecule with one arm embedded in the mitochondrial inner membane and one arm protruding into the matrix, the peripheral arm. The assembly of complex I is a semi-sequential process in which different preassembled subcomplexes are joined to form the holoenzyme.	None	The authors assume an additional component (homolog to the bovine 10.6K protein).	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cytochrome c oxidase subunit NDUFA4;Acyl carrier protein, mitochondrial;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial;NADH dehydrogenase [ubiquinone] 1 subunit C2;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10;NADH-ubiquinone oxidoreductase chain 4;NADH-ubiquinone oxidoreductase chain 5;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9	NDUFA4;NDUFAB1;NDUFB5;NDUFB3;NDUFB1;NDUFB6;NDUFB4;NDUFB8;NDUFB2;NDUFC2;NDUFB10;MT-ND4;MT-ND5;NDUFB7;NDUFB11;NDUFB9	None;None;None;None;None;None;None;None;None;None;None;MTND4 NADH4 ND4;MTND5 NADH5 ND5;None;None;LYRM3 UQOR22
2917	GRB2-SOS1 complex	Human	GRB2-SOS1 complex, Fc receptor gamma-R1 stimulated	None	P62993;Q07889	2885;6654	MI:0019-coimmunoprecipitation	GO:0007169;GO:0006955	transmembrane receptor protein tyrosine kinase signaling pathway;immune response	30.05.01.12;36.25.16	transmembrane receptor protein tyrosine kinase signalling pathways;immune response	9716598	In literature it has been shown that Grb2 binds to the guanine nucleotide exchange factor Sos, leading to activation of Ras.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Growth factor receptor-bound protein 2;Son of sevenless homolog 1	GRB2;SOS1	ASH;None
2918	Ku antigen-YY1-alphaMyHC promoter complex	Human	Ku70-Ku80-YY1-alphaMyHC promoter complex	None	P12956;P13010;P25490	2547;7520;7528	MI:0006-anti bait coimmunoprecipitation;MI:0412-electrophoretic mobility supershift assay	GO:0045892;GO:0003677;GO:0005634	negative regulation of DNA-templated transcription;DNA binding;nucleus	11.02.03.04.03;16.03.01;70.10	transcription repression;DNA binding;nucleus	15367688	Ku complex binds to the human alphaMyHC promoter and represses alphaMyHC expression. Ku70 and YY1 protein levels are increased in patients with heart failure.	Human heart failure	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	X-ray repair cross-complementing protein 6;X-ray repair cross-complementing protein 5;Transcriptional repressor protein YY1	XRCC6;XRCC5;YY1	G22P1;G22P2;INO80S
2919	Respiratory chain complex I (gamma subunit), mitochondrial	Human	NADH:ubiquinone oxidoreductase (EC 1.6.5.3) gamma subunit	HEK 293 cells; 143B osteosarcoma cells	O15239;O43677;O43920;O95167;O95299;P03886;P03891;P03897;P03901;P03923;P51970;P56556;Q16795	4694;4717;4725;4696;4705;4535;4536;4537;4539;4541;4702;4700;4704	MI:0047-far western blotting;MI:0276-blue native page	GO:0022904;GO:0005743;GO:0006119;GO:0009060;GO:1902600;GO:0065003	respiratory electron transport chain;mitochondrial inner membrane;oxidative phosphorylation;aerobic respiration;proton transmembrane transport;protein-containing complex assembly	02.11.07;20.01.15;70.16.05;02.13.03	regulation of electron transport and membrane-associated energy conservation;electron transport;mitochondrial inner membrane;aerobic respiration	15317750	Complex I couples the transfer of two electrons from NADH to ubiquinone to the translocation of four protons across the mitochondrial inner membrane.Complex I  is an L-shaped molecule with one arm embedded in the mitochondrial inner membane and one arm protruding into the matrix, the peripheral arm.The assembly of complex I is a semi-sequential process in which different preassembled subcomplexes are joined to form the holoenzyme.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1;NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial;NADH dehydrogenase [ubiquinone] iron-sulfur protein 5;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial;NADH-ubiquinone oxidoreductase chain 1;NADH-ubiquinone oxidoreductase chain 2;NADH-ubiquinone oxidoreductase chain 3;NADH-ubiquinone oxidoreductase chain 4L;NADH-ubiquinone oxidoreductase chain 6;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial	NDUFA1;NDUFC1;NDUFS5;NDUFA3;NDUFA10;MT-ND1;MT-ND2;MT-ND3;MT-ND4L;MT-ND6;NDUFA8;NDUFA6;NDUFA9	None;None;None;None;None;MTND1 NADH1 ND1;MTND2 NADH2 ND2;MTND3 NADH3 ND3;MTND4L NADH4L ND4L;MTND6 NADH6 ND6;None;LYRM6 NADHB14;NDUFS2L
2920	Respiratory chain complex I (lambda subunit), mitochondrial	Human	NADH:ubiquinone oxidoreductase (EC 1.6.5.3) lambda subunit	HEK 293 cells; 143B osteosarcoma cells	O00217;O43181;O43678;O75251;O75306;O75380;O75489;O95182;P19404;P28331;P49821;P56181;Q16718;Q86Y39;Q9P0J0;Q9UI09	4728;4724;4695;374291;4720;4726;4722;4701;4729;4719;4723;4731;4698;126328;51079;55967	MI:0047-far western blotting;MI:0276-blue native page	GO:0022904;GO:0005743;GO:0006119;GO:0009060;GO:1902600;GO:0065003	respiratory electron transport chain;mitochondrial inner membrane;oxidative phosphorylation;aerobic respiration;proton transmembrane transport;protein-containing complex assembly	02.11.07;20.01.15;70.16.05;02.13.03	regulation of electron transport and membrane-associated energy conservation;electron transport;mitochondrial inner membrane;aerobic respiration	15317750	Complex I couples the transfer of two electrons from NADH to ubiquinone to the translocation of four protons across the mitochondrial inner membrane.Complex I  is an L-shaped molecule with one arm embedded in the mitochondrial inner membane and one arm protruding into the matrix, the peripheral arm.The assembly of complex I is a semi-sequential process in which different preassembled subcomplexes are joined to form the holoenzyme.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial;NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2;NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial;NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial;NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial;NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7;NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial;NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial;NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial;NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12	NDUFS8;NDUFS4;NDUFA2;NDUFS7;NDUFS2;NDUFS6;NDUFS3;NDUFA7;NDUFV2;NDUFS1;NDUFV1;NDUFV3;NDUFA5;NDUFA11;NDUFA13;NDUFA12	None;None;None;None;None;None;None;None;None;None;UQOR1;None;None;None;GRIM19;DAP13
2921	SHARP-CtBP complex	Human	None	None	P56545;Q13363;Q96T58	1488;1487;23013	MI:0007-anti tag coimmunoprecipitation	GO:0045892;GO:0003677;GO:0007219;GO:0005634	negative regulation of DNA-templated transcription;DNA binding;Notch signaling pathway;nucleus	11.02.03.04.03;16.03.01;30.05.02.14;70.10	transcription repression;DNA binding;Notch-receptor signalling pathway;nucleus	16287852	CtBP augments SHARP-mediated repression.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	C-terminal-binding protein 2;C-terminal-binding protein 1;Msx2-interacting protein	CTBP2;CTBP1;SPEN	None;CTBP;KIAA0929 MINT SHARP
2922	LAT-PLC-gamma-1-p85-GRB2-SOS signaling complex, C305 activated	Human	None	None	O43561;P19174;P27986;P62993;Q07889	27040;5335;5295;2885;6654	MI:0019-coimmunoprecipitation	GO:0007169;GO:0050896;GO:0048015	transmembrane receptor protein tyrosine kinase signaling pathway;response to stimulus;phosphatidylinositol-mediated signaling	30.05.01.12;36.25	transmembrane receptor protein tyrosine kinase signalling pathways;animal specific systemic sensing and response	9489702	The authors show that upon tyrosine phosphorylation, LAT binds Grb2, PLC-gamma1, the p85 subunit of PI3K, and other critical signaling molecules. They provide evidence that LAT plays an important role in linking the TCR to cellular activation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Linker for activation of T-cells family member 1;1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1;Phosphatidylinositol 3-kinase regulatory subunit alpha;Growth factor receptor-bound protein 2;Son of sevenless homolog 1	LAT;PLCG1;PIK3R1;GRB2;SOS1	None;PLC1;GRB1;ASH;None
2923	SHARP-CtBP1-CtIP complex	Human	None	None	Q13363;Q96T58;Q99708	1487;23013;5932	MI:0007-anti tag coimmunoprecipitation	GO:0045892;GO:0003677;GO:0007219;GO:0005634	negative regulation of DNA-templated transcription;DNA binding;Notch signaling pathway;nucleus	11.02.03.04.03;16.03.01;30.05.02.14;70.10	transcription repression;DNA binding;Notch-receptor signalling pathway;nucleus	16287852	CtIP and CtBP augment SHARP-mediated repression.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	C-terminal-binding protein 1;Msx2-interacting protein;DNA endonuclease RBBP8	CTBP1;SPEN;RBBP8	CTBP;KIAA0929 MINT SHARP;CTIP
2930	SHARP-CtIP-RBP-Jkappa complex	Human	None	None	Q06330;Q96T58;Q99708	3516;23013;5932	MI:0007-anti tag coimmunoprecipitation	GO:0045892;GO:0003677;GO:0007219;GO:0005634	negative regulation of DNA-templated transcription;DNA binding;Notch signaling pathway;nucleus	11.02.03.04.03;16.03.01;30.05.02.14;70.10	transcription repression;DNA binding;Notch-receptor signalling pathway;nucleus	16287852	The ternary complex is formed only when both SHARP and CtIP are expressed.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Recombining binding protein suppressor of hairless;Msx2-interacting protein;DNA endonuclease RBBP8	RBPJ;SPEN;RBBP8	IGKJRB IGKJRB1 RBPJK RBPSUH;KIAA0929 MINT SHARP;CTIP
2931	SHARP-CtBP1-CtIP-RBP-Jkappa corepressor complex	Human	None	None	Q06330;Q13363;Q96T58;Q99708	3516;1487;23013;5932	MI:0004-affinity chromatography technology;MI:0232-transcriptional complementation assay	GO:0045892;GO:0003677;GO:0007219;GO:0005634	negative regulation of DNA-templated transcription;DNA binding;Notch signaling pathway;nucleus	11.02.03.04.03;16.03.01;30.05.02.14;70.10	transcription repression;DNA binding;Notch-receptor signalling pathway;nucleus	16287852	The corepressor complex containing CtIP/CtBP probably facilitates RBP-Jkappa/SHARP-mediated repression of Notch target genes.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Recombining binding protein suppressor of hairless;C-terminal-binding protein 1;Msx2-interacting protein;DNA endonuclease RBBP8	RBPJ;CTBP1;SPEN;RBBP8	IGKJRB IGKJRB1 RBPJK RBPSUH;CTBP;KIAA0929 MINT SHARP;CTIP
2936	Ecsit complex (ECSIT, GAPDH, MT-CO2, NDUFAF1, TRAF6)	Human	None	HeLa mitochondria; HEK293 mitochondria	P00403;P04406;Q9BQ95;Q9Y375;Q9Y4K3	4513;2597;51295;51103;7189	MI:0047-far western blotting;MI:0663-confocal microscopy	GO:0005739;GO:0034985;GO:0065003	mitochondrion;Ecsit-NDUFAF1 complex;protein-containing complex assembly	70.16	mitochondrion	17344420	Ecsit is a cytosolic adaptor protein essential for inflammatory response and embryonic development via the Toll-like and BMP (bone morphogenetic protein) signal transduction pathways, respectively. Here, a mitochondrial function for Ecsit (an evolutionary conserved signaling intermediate in Toll pathways) in the assembly of mitochondrial complex I (NADH:ubiquinone oxidoreductase) has also been demonstrated. Ecsit isoform 1 copurifies with tandem affinity-purified NDUFAF1.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cytochrome c oxidase subunit 2;Glyceraldehyde-3-phosphate dehydrogenase;Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial;Complex I intermediate-associated protein 30, mitochondrial;TNF receptor-associated factor 6	MT-CO2;GAPDH;ECSIT;NDUFAF1;TRAF6	COII COX2 COXII MTCO2;GAPD;None;CIA30;RNF85
2937	PTF1-bHLH complex	Human	None	pancreas	Q7RTS3;Q99081	256297;6938	MI:0412-electrophoretic mobility supershift assay	GO:2001141;GO:0006355;GO:0003677;GO:0031016;GO:0005634	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;DNA binding;pancreas development;nucleus	11.02.03.04;16.03.01;47.03.11.09;70.10	transcriptional control;DNA binding;pancreas;nucleus	11562365	PTF1, containing P48 and a form of HEB, can bind to and mediate the acinar activity of the A element of the ELA1 gene enhancer.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Pancreas transcription factor 1 subunit alpha;Transcription factor 12	PTF1A;TCF12	BHLHA29 PTF1P48;BHLHB20 HEB HTF4
2938	ECSIT complex (ECSIT, NDUFS3, TOMM20)	Human	None	HeLa mitochondria; HEK293 mitochondria	O75489;Q15388;Q9BQ95	4722;9804;51295	MI:0047-far western blotting;MI:0276-blue native page	GO:0005739;GO:0065003	mitochondrion;protein-containing complex assembly	70.16	mitochondrion	17344420	Ecsit is a cytosolic adaptor protein essential for inflammatory response and embryonic development via the Toll-like and BMP (bone morphogenetic protein) signal transduction pathways, respectively. Here, a mitochondrial function for Ecsit (an evolutionary conserved signalling intermediate in Toll pathways) in the assembly of mitochondrial complex I (NADH:ubiquinone oxidoreductase) has also been demonstrated. Ecsit isoform 1 copurifies with tandem affinity-purified NDUFAF1.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial;Mitochondrial import receptor subunit TOM20 homolog;Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial	NDUFS3;TOMM20;ECSIT	None;KIAA0016;None
2939	Ecsit complex (ECSIT, MT-CO2, MT-ND1, NDUFA1, NDUFAF1, TRAF6)	Human	None	HeLa mitochondria; HEK293 mitochondria	O15239;P00403;P03886;Q9BQ95;Q9Y375;Q9Y4K3	4694;4513;4535;51295;51103;7189	MI:0007-anti tag coimmunoprecipitation;MI:0047-far western blotting;MI:0400-affinity technology	GO:0005739;GO:0034985;GO:0065003	mitochondrion;Ecsit-NDUFAF1 complex;protein-containing complex assembly	70.16	mitochondrion	17344420	Ecsit is a cytosolic adaptor protein essential for inflammatory response and embryonic development via the Toll-like and BMP (bone morphogenetic protein) signal transduction pathways, respectively. Here, a mitochondrial function for Ecsit (an evolutionary conserved signaling intermediate in Toll pathways) in the assembly of mitochondrial complex I (NADH:ubiquinone oxidoreductase) has also been demonstrated. Ecsit isoform 1 copurifies with tandem affinity-purified NDUFAF1.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1;Cytochrome c oxidase subunit 2;NADH-ubiquinone oxidoreductase chain 1;Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial;Complex I intermediate-associated protein 30, mitochondrial;TNF receptor-associated factor 6	NDUFA1;MT-CO2;MT-ND1;ECSIT;NDUFAF1;TRAF6	None;COII COX2 COXII MTCO2;MTND1 NADH1 ND1;None;CIA30;RNF85
2942	Ecsit complex (ECSIT, NDUFS3, NDUFAF1)	Human	None	HeLa mitochondria; HEK293 mitochondria	O75489;Q9BQ95;Q9Y375	4722;51295;51103	MI:0047-far western blotting;MI:0400-affinity technology	GO:0005739;GO:0034985;GO:0065003	mitochondrion;Ecsit-NDUFAF1 complex;protein-containing complex assembly	70.16	mitochondrion	17344420	Ecsit is a cytosolic adaptor protein essential for inflammatory response and embryonic development via the Toll-like and BMP (bone morphogenetic protein) signal transduction pathways, respectively. Here, a mitochondrial function for Ecsit (an evolutionary conserved signaling intermediate in Toll pathways) in the assembly of mitochondrial complex I (NADH:ubiquinone oxidoreductase) has also been demonstrated. Ecsit isoform 1 copurifies with tandem affinity-purified NDUFAF1.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial;Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial;Complex I intermediate-associated protein 30, mitochondrial	NDUFS3;ECSIT;NDUFAF1	None;None;CIA30
2943	Respiratory chain complex I (incomplete NDUFAF1 assembly), mitochondrial	Human	NADH:ubiquinone oxidoreductase (EC 1.6.5.3) incomplete intermediate	HeLa cells; HEK293 cells	P03886;Q9Y375	4535;51103	MI:0047-far western blotting;MI:0051-fluorescence technology	GO:0022904;GO:0005743;GO:0006119;GO:0009060;GO:1902600;GO:0065003	respiratory electron transport chain;mitochondrial inner membrane;oxidative phosphorylation;aerobic respiration;proton transmembrane transport;protein-containing complex assembly	02.11.07;20.01.15;70.16.05;02.13.03	regulation of electron transport and membrane-associated energy conservation;electron transport;mitochondrial inner membrane;aerobic respiration	16218961	Complex I is the first multiprotein complex of the OXPHOS system and participates in the formation of a proton gradient across the inner mitochondrial membrane coupled to transfer of electrons from NADH to ubiquinone. NDUFAF1 is a crucial component in the early assembly/stability of complex I.	None	None	Homo sapiens (Human);Homo sapiens (Human)	NADH-ubiquinone oxidoreductase chain 1;Complex I intermediate-associated protein 30, mitochondrial	MT-ND1;NDUFAF1	MTND1 NADH1 ND1;CIA30
2944	Notch1-p56lck-PI3K complex	Human	None	None	P06239;P27986;P46531	3932;5295;4851	MI:0006-anti bait coimmunoprecipitation;MI:0007-anti tag coimmunoprecipitation	GO:0045893;GO:0007219;GO:0043066;GO:0030217	positive regulation of DNA-templated transcription;Notch signaling pathway;negative regulation of apoptotic process;T cell differentiation	11.02.03.04.01;30.05.02.14;40.10.02.01;43.03.07.02.01.02	transcription activation;Notch-receptor signalling pathway;anti-apoptosis;T-cell	14583609	Anti-apoptotic function may result from elevated expression of anti-apoptotic genes like IAP-2, Bcl-xl or FLIP.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Tyrosine-protein kinase Lck;Phosphatidylinositol 3-kinase regulatory subunit alpha;Neurogenic locus notch homolog protein 1	LCK;PIK3R1;NOTCH1	None;GRB1;TAN1
2945	RBP-Jkappa-RING1-KyoT2 complex	Human	None	None	Q06330;Q06587;Q13642	3516;6015;2273	MI:0007-anti tag coimmunoprecipitation	GO:0045892;GO:0003677;GO:0005515;GO:0007219;GO:0005634	negative regulation of DNA-templated transcription;DNA binding;protein binding;Notch signaling pathway;nucleus	11.02.03.04.03;16.03.01;16.01;30.05.02.14;70.10	transcription repression;DNA binding;protein binding;Notch-receptor signalling pathway;nucleus	14999091	Overexpression of RING1 And KyoT2 inhibits transactivation of RBP-Jkappa by Notch.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Recombining binding protein suppressor of hairless;E3 ubiquitin-protein ligase RING1;Four and a half LIM domains protein 1	RBPJ;RING1;FHL1	IGKJRB IGKJRB1 RBPJK RBPSUH;RNF1;SLIM1
2946	YY1-Notch1-RBP-Jkappa complex	Human	None	None	P25490;P46531;Q06330	7528;4851;3516	MI:0006-anti bait coimmunoprecipitation;MI:0029-cosedimentation through density gradient;MI:0402-chromatin immunoprecipitation assay	GO:0045893;GO:0003677;GO:0007219;GO:0005634	positive regulation of DNA-templated transcription;DNA binding;Notch signaling pathway;nucleus	11.02.03.04.01;16.03.01;30.05.02.14;70.10	transcription activation;DNA binding;Notch-receptor signalling pathway;nucleus	12913000	YY1 indirectly binds to CBF1-response element via association with the intracellular domain of Notch1 (N1IC). N1IC interacts directly with CBF1(RBP-Jkappa).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transcriptional repressor protein YY1;Neurogenic locus notch homolog protein 1;Recombining binding protein suppressor of hairless	YY1;NOTCH1;RBPJ	INO80S;TAN1;IGKJRB IGKJRB1 RBPJK RBPSUH
2947	YY1-Notch1 complex	Human	None	K562 cells	P25490;P46531	7528;4851	MI:0006-anti bait coimmunoprecipitation;MI:0029-cosedimentation through density gradient;MI:0402-chromatin immunoprecipitation assay	GO:0003677;GO:0007219;GO:0005634	DNA binding;Notch signaling pathway;nucleus	16.03.01;30.05.02.14;70.10	DNA binding;Notch-receptor signalling pathway;nucleus	12913000	Transcription factor Ying Yang 1 (YY1) is associated with exogenous N1IC in human K562 erythroleukemic cells. The ankyrin (ANK) domain of N1IC and zinc finger domains of YY1 are essential for the association of N1IC and YY1.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Transcriptional repressor protein YY1;Neurogenic locus notch homolog protein 1	YY1;NOTCH1	INO80S;TAN1
2948	Respiratory chain complex I (incomplete intermediate), mitochondrial	Human	NADH:ubiquinone oxidoreductase (EC 1.6.5.3) incomplete intermediate	human primary skin fibroblasts	O43181;O75251;O75306;O75380;O95169;O95299;P19404;P28331;P49821;P56181;Q16795	4724;374291;4720;4726;4714;4705;4729;4719;4723;4731;4704	MI:0047-far western blotting;MI:0276-blue native page	GO:0022904;GO:0005743;GO:0006119;GO:0009060;GO:1902600;GO:0065003	respiratory electron transport chain;mitochondrial inner membrane;oxidative phosphorylation;aerobic respiration;proton transmembrane transport;protein-containing complex assembly	02.11.07;20.01.15;70.16.05;02.13.03	regulation of electron transport and membrane-associated energy conservation;electron transport;mitochondrial inner membrane;aerobic respiration	17438127	Complex I is the first multiprotein complex of the OXPHOS system and participates in the formation of a proton gradient across the inner mitochondrial membrane coupled to transfer of electrons from NADH to ubiquinone.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial;NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial;NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial;NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial;NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial;NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial;NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial;NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial	NDUFS4;NDUFS7;NDUFS2;NDUFS6;NDUFB8;NDUFA10;NDUFV2;NDUFS1;NDUFV1;NDUFV3;NDUFA9	None;None;None;None;None;None;None;None;UQOR1;None;NDUFS2L
2955	LCK-SLP76-PLC-gamma-1-LAT complex, pervanadate-activated	Human	None	None	O43561;P06239;P19174;Q13094	27040;3932;5335;3937	MI:0019-coimmunoprecipitation	GO:0007169;GO:0050896	transmembrane receptor protein tyrosine kinase signaling pathway;response to stimulus	30.05.01.12;36.25	transmembrane receptor protein tyrosine kinase signalling pathways;animal specific systemic sensing and response	16938345	The authors show that in pervanadate-treated Jurkat cells, but not in J.CaM1.6 cells, three tyrosine-phosphorylated proteins with molecular weights about 59, 76 and 150 Kd, corresponding to Lck, SLP76, PLC-gamma-1 were co-precipitated with LAT.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Linker for activation of T-cells family member 1;Tyrosine-protein kinase Lck;1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1;Lymphocyte cytosolic protein 2	LAT;LCK;PLCG1;LCP2	None;None;PLC1;None
2956	PLC-gamma-1-LAT-c-CBL complex, OKT3 stimulated	Human	None	None	O43561;P19174;P22681	27040;5335;867	MI:0019-coimmunoprecipitation	GO:0007169;GO:0050896	transmembrane receptor protein tyrosine kinase signaling pathway;response to stimulus	30.05.01.12;36.25	transmembrane receptor protein tyrosine kinase signalling pathways;animal specific systemic sensing and response	16938345	The authors show that  upon OKT3 stimulation, an extensive phosphorylation of LAT was seen in J2.LAT cells, but the phosphorylation of LAT F171F191 was barely detectable.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Linker for activation of T-cells family member 1;1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1;E3 ubiquitin-protein ligase CBL	LAT;PLCG1;CBL	None;PLC1;CBL2 RNF55
2957	LAT-GRB2 complex, Fyn-mLck(KA) or Syk kinase activated	Human	None	None	O43561;P62993	27040;2885	MI:0019-coimmunoprecipitation	GO:0007169;GO:0050896	transmembrane receptor protein tyrosine kinase signaling pathway;response to stimulus	30.05.01.12;36.25	transmembrane receptor protein tyrosine kinase signalling pathways;animal specific systemic sensing and response	16938345	The authors show that in the absence of a kinase, the association of LAT and Grb2 was not detected. Grb2 was co-precipitated with LAT, but not with LATF171F191, in the presence of Fyn, mLck(KA) or Syk kinases.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Linker for activation of T-cells family member 1;Growth factor receptor-bound protein 2	LAT;GRB2	None;ASH
2958	SMAD1-CBP complex	Human	None	None	Q15797;Q92793	4086;1387	MI:0007-anti tag coimmunoprecipitation	GO:0006265;GO:0045893;GO:0006473;GO:0006476;GO:0007179;GO:0051276;GO:0005634	DNA topological change;positive regulation of DNA-templated transcription;protein acetylation;protein deacetylation;transforming growth factor beta receptor signaling pathway;chromosome organization;nucleus	10.01.09.05;11.02.03.04.01;14.07.04;30.05.01.18.01;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription activation;modification by acetylation, deacetylation;TGF-beta-receptor signalling pathway;organization of chromosome structure;nucleus	10673036	SMAD1 stimulates transcription cooperatively with CBP.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Mothers against decapentaplegic homolog 1;CREB-binding protein	SMAD1;CREBBP	BSP1 MADH1 MADR1;CBP
2959	SMAD1-OAZ-HsN3 complex	Human	None	COS cells	P28070;P54368;Q15797	5692;4946;4086	MI:0006-anti bait coimmunoprecipitation	GO:2001141;GO:0006355;GO:0043161;GO:0006511;GO:0003677;GO:0007179;GO:0005634	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;proteasome-mediated ubiquitin-dependent protein catabolic process;ubiquitin-dependent protein catabolic process;DNA binding;transforming growth factor beta receptor signaling pathway;nucleus	11.02.03.04;14.13.01.01;16.03.01;30.05.01.18.01;70.10	transcriptional control;proteasomal degradation (ubiquitin/proteasomal pathway);DNA binding;TGF-beta-receptor signalling pathway;nucleus	12097147	The interaction of the subunits is enhanced upon BMP type I receptor activation and occur prior to the incorporation of HsN3 into the mature 20S proteasome. Furthermore, BMPs trigger the translocation of the complex to the nucleus.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Proteasome subunit beta type-4;Ornithine decarboxylase antizyme 1;Mothers against decapentaplegic homolog 1	PSMB4;OAZ1;SMAD1	PROS26;OAZ;BSP1 MADH1 MADR1
2960	SLP-76-PLC-gamma-1-ITK complex, alpha-TCR stimulated	Human	None	None	P19174;Q08881;Q13094	5335;3702;3937	MI:0019-coimmunoprecipitation	GO:0023052;GO:0048015	signaling;phosphatidylinositol-mediated signaling	30.01	cellular signalling	17148460	The authors speculate that SLP-76 may activate PLC-gamma-1 by regulating the ITK-mediated phosphorylation of PLC-gamma-1 at Tyr783.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1;Tyrosine-protein kinase ITK/TSK;Lymphocyte cytosolic protein 2	PLCG1;ITK;LCP2	PLC1;EMT LYK;None
2961	SLP-76-PLC-gamma-1-VAV complex, alpha-TCR stimulated	Human	None	None	P15498;P19174;Q13094	7409;5335;3937	MI:0019-coimmunoprecipitation	GO:0023052;GO:0048015	signaling;phosphatidylinositol-mediated signaling	30.01	cellular signalling	17148460	SLP-76 inducibly associated with both Vav and catalytically active ITK, which efficiently phosphorylated a PLC-gamma1 fragment at Tyr783 in vitro.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Proto-oncogene vav;1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1;Lymphocyte cytosolic protein 2	VAV1;PLCG1;LCP2	VAV;PLC1;None
2962	CRK-BCAR1-DOCK1 complex	Human	None	None	P46108;P56945;Q14185	1398;9564;1793	MI:0019-coimmunoprecipitation	GO:0007229;GO:0006909;GO:0043067	integrin-mediated signaling pathway;phagocytosis;regulation of programmed cell death	30.05.02.26;36.25.16.01.03;40.10.02.04	integrin receptor signalling pathway;phagocyte response (e.g. macrophages, dendritic cells, granulocytes);regulation of apoptosis	11146654	Alpha(v)beta5 integrin binds to the apoptotic cell for recruitment of this complex to the membrane.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Adapter molecule crk;Breast cancer anti-estrogen resistance protein 1;Dedicator of cytokinesis protein 1	CRK;BCAR1;DOCK1	None;CAS CASS1 CRKAS;None
2963	ITK-SLP-76 complex, anti-TCR stimulated	Human	None	None	Q08881;Q13094	3702;3937	MI:0006-anti bait coimmunoprecipitation;MI:0007-anti tag coimmunoprecipitation	GO:0023052;GO:0050896;GO:0048015	signaling;response to stimulus;phosphatidylinositol-mediated signaling	30.01;36.25	cellular signalling;animal specific systemic sensing and response	17420479	The authors show that catalytically active ITK is found primarily in complex with SLP-76. Further they demonstrate that a continued interaction with SLP-76 is required to maintain ITK in an active state.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Tyrosine-protein kinase ITK/TSK;Lymphocyte cytosolic protein 2	ITK;LCP2	EMT LYK;None
2966	NuMA-LGN-G-alpha-i-1 complex	Human	None	None	P63096;P81274;Q14980	2770;29899;4926	MI:0007-anti tag coimmunoprecipitation;MI:0096-pull down	GO:0000278;GO:0051726;GO:0051225;GO:0007098	mitotic cell cycle;regulation of cell cycle;spindle assembly;centrosome cycle	10.03.01.01;10.03.01;10.03.05.01	mitotic cell cycle;mitotic cell cycle and cell cycle control;spindle pole body/centrosome and microtubule cycle	15537540	The authors propose that the trimeric NuMA-LGN-G-alpha complex regulates the interaction of aster MTs with the cell cortex. They analyzed with a FRET biosensor that LGN behaves as a conformational switch: in its closed state, the N and C termini interact, but NuMA or G-alpha-i can disrupt this association, allowing LGN to interact simultaneously with both proteins, resulting in their cortical localization.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(i) subunit alpha-1;G-protein-signaling modulator 2;Nuclear mitotic apparatus protein 1	GNAI1;GPSM2;NUMA1	None;LGN;NMP22 NUMA
2968	Axin-SMAD3 complex	Human	None	HEK293T cells	O15169;P84022	8312;4088	MI:0007-anti tag coimmunoprecipitation	GO:0007179;GO:0005737	transforming growth factor beta receptor signaling pathway;cytoplasm	30.05.01.18.01;70.03	TGF-beta-receptor signalling pathway;cytoplasm	11438668	Phosphorylation of SMAD3 by T(beta)R-I is faciliated in the presence of Axin. In the absence of ligand stimulation, Axin was colocalized with Smad3 in the cytoplasm in vivo. Upon receptor activation, Smad3 was strongly phosphorylated by TGF-beta type I receptor (TbetaR-I) in the presence of Axin, and dissociated from TbetaR-I and Axin.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Axin-1;Mothers against decapentaplegic homolog 3	AXIN1;SMAD3	AXIN;MADH3
2970	mTORC1 complex (MLST8, MTOR, RAPTOR)	Human	None	HEK293 cells; HeLa cells	P42345;Q8N122;Q9BVC4	2475;57521;64223	MI:0019-coimmunoprecipitation;MI:0047-far western blotting;MI:0051-fluorescence technology	GO:0000902;GO:0016049;GO:0071900;GO:0033554;GO:0019725;GO:0010507	cell morphogenesis;cell growth;regulation of protein serine/threonine kinase activity;cellular response to stress;cellular homeostasis;negative regulation of autophagy	40.01	cell growth / morphogenesis	15467718	mTORC1 and mTORC2 constitute a primordial signalling network conserved in eukaryotic evolution to control the fundamental process of cell growth.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein kinase mTOR;Regulatory-associated protein of mTOR;Target of rapamycin complex subunit LST8	MTOR;RPTOR;MLST8	FRAP FRAP1 FRAP2 RAFT1 RAPT1;KIAA1303 RAPTOR;GBL, LST8
2971	ITGA9-ITGB1-VEGFC complex	Human	integrin complex	None	P05556;P49767;Q13797	3688;7424;3680	MI:0004-affinity chromatography technology	GO:0016477;GO:0007155;GO:0030154	cell migration;cell adhesion;cell differentiation	34.05.01;34.07;40.02	cell migration;cell adhesion;cell differentiation	15590642	Alpha9-beta1 directly binds to VEGF-C and -D and contributes to lymphangiogenesis.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-1;Vascular endothelial growth factor C;Integrin alpha-9	ITGB1;VEGFC;ITGA9	FNRB, MDF2, MSK12;None;None
2972	ITGA9-ITGB1-VEGFA complex	Human	integrin complex	None	P05556;P15692;Q13797	3688;7422;3680	MI:0004-affinity chromatography technology	GO:0001525	angiogenesis	41.05.16	angiogenesis	15590642	Alpha9-beta1 integrin binds the VEGF121 isoform of VEGF-A.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-1;Vascular endothelial growth factor A;Integrin alpha-9	ITGB1;VEGFA;ITGA9	FNRB, MDF2, MSK12;VEGF;None
2975	SMAD3-E2F4/5-p107-DP1 complex	Human	None	None	P28749;P84022;Q14186;Q15329;Q16254	5933;4088;7027;1875;1874	MI:0007-anti tag coimmunoprecipitation	GO:0007179;GO:0005737	transforming growth factor beta receptor signaling pathway;cytoplasm	30.05.01.18.01;70.03	TGF-beta-receptor signalling pathway;cytoplasm	12150994	This complex preexists in the cytoplasm. In response to TGF-beta, this complex moves to the nucleus and associates with SMAD4.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Retinoblastoma-like protein 1;Mothers against decapentaplegic homolog 3;Transcription factor Dp-1;Transcription factor E2F5;Transcription factor E2F4	RBL1;SMAD3;TFDP1;E2F5;E2F4	None;MADH3;DP1;None;None
2985	mTOR complex (MTOR, RAPTOR)	Human	Nutrient-sensitive complex NSC	HEK293T cells	P42345;Q8N122	2475;57521	MI:0019-coimmunoprecipitation;MI:0047-far western blotting	GO:0000902;GO:0016049	cell morphogenesis;cell growth	40.01	cell growth / morphogenesis	12150925	mTOR/RAFT1/FRAP is the target of the immunosuppressive drug rapamycin and the central component of a nutrient- and hormone-sensitive signaling pathway that regulates cell growth.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein kinase mTOR;Regulatory-associated protein of mTOR	MTOR;RPTOR	FRAP FRAP1 FRAP2 RAFT1 RAPT1;KIAA1303 RAPTOR
2989	ITGA9-ITGB1-ADAM8 complex	Human	integrin complex	None	P05556;P78325;Q13797	3688;101;3680	MI:0004-affinity chromatography technology	GO:0005515;GO:0007155;GO:0001503;GO:0030316	protein binding;cell adhesion;ossification;osteoclast differentiation	16.01;34.07;41.05.17;45.03.05.07	protein binding;cell adhesion;osteogenesis;bone	16995821	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-1;Disintegrin and metalloproteinase domain-containing protein 8;Integrin alpha-9	ITGB1;ADAM8;ITGA9	FNRB, MDF2, MSK12;MS2;None
2992	Ubiquitin E3 ligase (SMAD7, SMURF2)	Human	SMAD7-SMURF2 complex	None	O15105;Q9HAU4	4092;64750	MI:0007-anti tag coimmunoprecipitation	GO:0016567;GO:0043161;GO:0006511;GO:0005515;GO:0005737;GO:0005634	protein ubiquitination;proteasome-mediated ubiquitin-dependent protein catabolic process;ubiquitin-dependent protein catabolic process;protein binding;cytoplasm;nucleus	14.07.05;14.13.01.01;16.01;70.03;70.10	modification by ubiquitination, deubiquitination;proteasomal degradation (ubiquitin/proteasomal pathway);protein binding;cytoplasm;nucleus	11163210	SMURF is localized in the nucleus, but binding to SMAD7 induces export to the cytoplasm.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Mothers against decapentaplegic homolog 7;E3 ubiquitin-protein ligase SMURF2	SMAD7;SMURF2	MADH7 MADH8;None
2996	Ubiquitin E3 ligase (SMAD7, SMURF1)	Human	SMAD7-SMURF1 complex	COS cells	O15105;Q9HCE7	4092;57154	MI:0007-anti tag coimmunoprecipitation	GO:0016567;GO:0043161;GO:0006511;GO:0005515;GO:0005737;GO:0005634	protein ubiquitination;proteasome-mediated ubiquitin-dependent protein catabolic process;ubiquitin-dependent protein catabolic process;protein binding;cytoplasm;nucleus	14.07.05;14.13.01.01;16.01;70.03;70.10	modification by ubiquitination, deubiquitination;proteasomal degradation (ubiquitin/proteasomal pathway);protein binding;cytoplasm;nucleus	11278251	SMAD7 associates with SMURF1 in the nucleus and is exported to the cytoplasm.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Mothers against decapentaplegic homolog 7;E3 ubiquitin-protein ligase SMURF1	SMAD7;SMURF1	MADH7 MADH8;KIAA1625
2997	Ubiquitin E3 ligase (SMAD7-SMURF1) - TGF(beta)	Human	SMAD7-SMURF1-TGF-beta receptor complex	COS cells	O15105;P36897;P37173;Q9HCE7	4092;7046;7048;57154	MI:0007-anti tag coimmunoprecipitation	GO:0016567;GO:0043161;GO:0006511;GO:0007179;GO:0005737	protein ubiquitination;proteasome-mediated ubiquitin-dependent protein catabolic process;ubiquitin-dependent protein catabolic process;transforming growth factor beta receptor signaling pathway;cytoplasm	14.07.05;14.13.01.01;30.05.01.18.01;70.03	modification by ubiquitination, deubiquitination;proteasomal degradation (ubiquitin/proteasomal pathway);TGF-beta-receptor signalling pathway;cytoplasm	11278251	SMAD7 enhances the interaction between SMURF1 and the TGF-beta receptor complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mothers against decapentaplegic homolog 7;TGF-beta receptor type-1;TGF-beta receptor type-2;E3 ubiquitin-protein ligase SMURF1	SMAD7;TGFBR1;TGFBR2;SMURF1	MADH7 MADH8;ALK5 SKR4;None;KIAA1625
2998	Axin-PP2A A-PP2A C-GSK3-beta-beta-catenin complex	Human	None	None	O15169;P35222;P49841;Q15172	8312;1499;2932;5525	MI:0007-anti tag coimmunoprecipitation	GO:0016055	Wnt signaling pathway	30.05.02.20	Wnt signalling pathway	11818547	The incubation of the lysates with casein kinase I isoform epsilon decreases the association of PP2A C and A with the beta-catenin degradation complex.	None	The authors describe as additional component of the complex "protein phosphatase PP2A C", that couldn't be identified.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Axin-1;Catenin beta-1;Glycogen synthase kinase-3 beta;Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform	AXIN1;CTNNB1;GSK3B;PPP2R5A	AXIN;CTNNB;None;None
3004	APC-AXIN1-CTNNB1 complex	Human	APC-Axin-1-beta-catenin complex, 23S APC-containing complex	None	O15169;P25054;P35222	8312;324;1499	MI:0029-cosedimentation through density gradient	GO:0016055	Wnt signaling pathway	30.05.02.20	Wnt signalling pathway	16188939	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Axin-1;Adenomatous polyposis coli protein;Catenin beta-1	AXIN1;APC;CTNNB1	AXIN;DP2.5;CTNNB
3008	60S APC containing complex	Human	None	epithelium	P23258;P25054;P46940;Q71U36	7283;324;8826;7846	MI:0029-cosedimentation through density gradient;MI:0226-ion exchange chromatography	GO:0030036;GO:0005737	actin cytoskeleton organization;cytoplasm	42.04.03;70.03	actin cytoskeleton;cytoplasm	17126424	The authors propose that 60S APC is a discrete high molecular weight complex with a novel function in cytoskeletal regulation in epithelial cells apart from its well established role in targeting catenin destruction or its proposed role in microtubule plus end stabilization.	None	Since the authors did not specify tubulin alpha as well as tubulin gamma, we used isoform tubulin alpha-1A chain  and isoform tubulin gamma-1 chain  , respectively.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Tubulin gamma-1 chain;Adenomatous polyposis coli protein;Ras GTPase-activating-like protein IQGAP1;Tubulin alpha-1A chain	TUBG1;APC;IQGAP1;TUBA1A	TUBG;DP2.5;KIAA0051;TUBA3
3011	APC-IQGAP1-Rac1 complex	Human	None	COS cells	P25054;P46940;P63000	324;8826;5879	MI:0006-anti bait coimmunoprecipitation	GO:0016477;GO:0007010;GO:0005856	cell migration;cytoskeleton organization;cytoskeleton	34.05.01;42.04;70.04	cell migration;cytoskeleton/structural proteins;cytoskeleton	15572129	When EGFP-APC-M1 (aa221-968) was immunoprecipitated from the cells expressing EGFP-APC-M1 and constitutively active Rac1 (Rac1V12), both Rac1V12 and IQGAP1 were coimmunoprecipitated. The authors showed that activated Rac1 and Cdc42 formed a tripartite complex with IQGAP1 and APC.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Adenomatous polyposis coli protein;Ras GTPase-activating-like protein IQGAP1;Ras-related C3 botulinum toxin substrate 1	APC;IQGAP1;RAC1	DP2.5;KIAA0051;TC25
3012	APC-IQGAP1-Cdc42 complex	Human	None	Vero cells	P25054;P46940;P60953	324;8826;998	MI:0006-anti bait coimmunoprecipitation	GO:0016477;GO:0007010;GO:0005856	cell migration;cytoskeleton organization;cytoskeleton	34.05.01;42.04;70.04	cell migration;cytoskeleton/structural proteins;cytoskeleton	15572129	When EGFP-APC-M1 (aa221-968) was immunoprecipitated from the cells expressing EGFP-APC-M1 and constitutively active Cdc42 (Cdc42V12), both Cdc42V12 and IQGAP1 were coimmunoprecipitated. The authors showed that activated Rac1 and Cdc42 formed a tripartite complex with IQGAP1 and APC.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Adenomatous polyposis coli protein;Ras GTPase-activating-like protein IQGAP1;Cell division control protein 42 homolog	APC;IQGAP1;CDC42	DP2.5;KIAA0051;None
3015	p27-cyclinE-Cdk2 - Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1) complex	Human	None	None	P24864;P24941;P46527;P61024;P62877;P63208;Q13309;Q13616	898;1017;1027;1163;9978;6500;6502;8454	MI:0007-anti tag coimmunoprecipitation	GO:0000278;GO:0006468;GO:0016567;GO:0006511	mitotic cell cycle;protein phosphorylation;protein ubiquitination;ubiquitin-dependent protein catabolic process	10.03.01.01;14.07.03;14.07.05;14.13.01.01	mitotic cell cycle;modification by phosphorylation, dephosphorylation, autophosphorylation;modification by ubiquitination, deubiquitination;proteasomal degradation (ubiquitin/proteasomal pathway)	17409098	p27, an important cell cycle regulator, blocks the G1/S transition in cells by binding and inhibiting Cdk2/cyclin A and Cdk2/cyclin E complexes. Ubiquitination and subsequent degradation play a critical role in regulating the levels of p27 during cell cycle progression.	Overexpression of p27 in certain cancer cells prevents DNA replication and tumor formation in nude mice, whereas the loss of p27 has been reported in many human cancers and predicts a poor prognosis in breast, prostate, colon, gastric, lung, and esophageal cancers. In several types of cancers, there is a strong correlation between the loss of p27 and induction of Skp2, a subunit of the SCFSkp2/Cks1 (Skp1, Cul1, Roc1, Skp2, Cks1 complex) ubiquitin E3 ligase that targets p27 for ubiquitination and degradation.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	G1/S-specific cyclin-E1;Cyclin-dependent kinase 2;Cyclin-dependent kinase inhibitor 1B;Cyclin-dependent kinases regulatory subunit 1;E3 ubiquitin-protein ligase RBX1;S-phase kinase-associated protein 1;S-phase kinase-associated protein 2;Cullin-1	CCNE1;CDK2;CDKN1B;CKS1B;RBX1;SKP1;SKP2;CUL1	CCNE;CDKN2;KIP1 p27;CKS1;RNF75 ROC1;EMC19 OCP2 SKP1A TCEB1L;FBXL1;None
3025	TGF-beta receptor II-TGF-beta3 complex	Human	None	None	P10600;P37173	7043;7048	MI:0404-comigration in non denaturing gel electrophoresis	GO:0005515;GO:0007179;GO:0005886;GO:0065003	protein binding;transforming growth factor beta receptor signaling pathway;plasma membrane;protein-containing complex assembly	16.01;30.05.01.18.01;70.02	protein binding;TGF-beta-receptor signalling pathway;eukaryotic plasma membrane / membrane attached	16289576	TGF-beta 3 binds to TGF-beta receptor type II sequentially.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Transforming growth factor beta-3 proprotein;TGF-beta receptor type-2	TGFB3;TGFBR2	None;None
3026	TGF-beta receptor II-TGF-beta1 complex	Human	None	None	P01137;P37173	7040;7048	MI:0404-comigration in non denaturing gel electrophoresis	GO:0005515;GO:0007179;GO:0005886;GO:0065003	protein binding;transforming growth factor beta receptor signaling pathway;plasma membrane;protein-containing complex assembly	16.01;30.05.01.18.01;70.02	protein binding;TGF-beta-receptor signalling pathway;eukaryotic plasma membrane / membrane attached	16289576	TGF-beta 1 binds to TGF-beta receptor type II sequentially.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Transforming growth factor beta-1 proprotein;TGF-beta receptor type-2	TGFB1;TGFBR2	TGFB;None
3028	TGF-beta receptor II-TGF-beta receptor I-TGF-beta3 complex	Human	None	None	P10600;P36897;P37173	7043;7046;7048	MI:0404-comigration in non denaturing gel electrophoresis	GO:0007179;GO:0005886	transforming growth factor beta receptor signaling pathway;plasma membrane	30.05.01.18.01;70.02	TGF-beta-receptor signalling pathway;eukaryotic plasma membrane / membrane attached	16289576	TGF-beta receptor I does not bind TGF-beta in the absence of TGF-beta receptor II.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transforming growth factor beta-3 proprotein;TGF-beta receptor type-1;TGF-beta receptor type-2	TGFB3;TGFBR1;TGFBR2	None;ALK5 SKR4;None
3031	TGFbetaRII-TGFbetaRI-TGFbeta1 complex	Human	TGF-beta receptor II-TGF-beta receptor I-TGF-beta1 complex	COS cells; lung	P01137;P36897;P37173	7040;7046;7048	MI:0006-anti bait coimmunoprecipitation	GO:0007179;GO:0005886	transforming growth factor beta receptor signaling pathway;plasma membrane	30.05.01.18.01;70.02	TGF-beta-receptor signalling pathway;eukaryotic plasma membrane / membrane attached	8051105	TGF-beta receptor I does not bind TGF-beta in the absence of TGF-beta receptor II.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transforming growth factor beta-1 proprotein;TGF-beta receptor type-1;TGF-beta receptor type-2	TGFB1;TGFBR1;TGFBR2	TGFB;ALK5 SKR4;None
3032	AGO2-DICER1-HSP90AB1-TARBP2 complex	Human	RISC-loading complex; RNA-induced silencing complex, RISC	HEK293 cells	P08238;Q15633;Q9UKV8;Q9UPY3	3326;6895;27161;23405	MI:0007-anti tag coimmunoprecipitation	GO:0032774;GO:0006396;GO:0003723;GO:0005737	RNA biosynthetic process;RNA processing;RNA binding;cytoplasm	11.02;11.04;16.03.03;70.03	RNA synthesis;RNA processing;RNA binding;cytoplasm	16357216	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Heat shock protein HSP 90-beta;RISC-loading complex subunit TARBP2;Protein argonaute-2;Endoribonuclease Dicer	HSP90AB1;TARBP2;AGO2;DICER1	HSP90B HSPC2 HSPCB;TRBP;EIF2C2;DICER HERNA KIAA0928
3033	PAC3-PAC4 complex	Human	None	HEK293T cells	Q5JS54;Q9BT73	389362;84262	MI:0007-anti tag coimmunoprecipitation	GO:0065003	protein-containing complex assembly	None	None	17707236	20S proteasome assembly is orchestrated by two distinct pairs of chaperones in mammals, the PAC1-PAC2 complex and the PAC3-PAC4 complex.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Proteasome assembly chaperone 4;Proteasome assembly chaperone 3	PSMG4;PSMG3	C6orf86 PAC4;C7orf48 PAC3
3034	PAC1-PAC2 complex	Human	None	HEK293T cells	O95456;Q969U7	8624;56984	MI:0007-anti tag coimmunoprecipitation	GO:0050821;GO:0006457;GO:0065003	protein stabilization;protein folding;protein-containing complex assembly	14.01	protein folding and stabilization	16251969	20S proteasome assembly is orchestrated by two distinct pairs of chaperones in mammals, the PAC1-PAC2 complex and the PAC3-PAC4 complex.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Proteasome assembly chaperone 1;Proteasome assembly chaperone 2	PSMG1;PSMG2	C21LRP DSCR2 PAC1;HCCA3 PAC2 TNFSF5IP1
3035	LAT2-ITGB1 complex	Human	None	epithelium	P05556;Q9UHI5	3688;23428	MI:0019-coimmunoprecipitation	GO:0098609	cell-cell adhesion	None	None	11507094	CD98-beta1 integrin association is required for focal adhesion kinase-dependent phosphoinositol 3-hydroxykinase activation and cellular transformation.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-1;Large neutral amino acids transporter small subunit 2	ITGB1;SLC7A8	FNRB, MDF2, MSK12;LAT2
3036	Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1)	Human	None	None	P61024;P62877;P63208;Q13309;Q13616	1163;9978;6500;6502;8454	MI:0007-anti tag coimmunoprecipitation	GO:0000278;GO:0051726;GO:0016567;GO:0006511	mitotic cell cycle;regulation of cell cycle;protein ubiquitination;ubiquitin-dependent protein catabolic process	10.03.01.01;10.03.01;14.07.05;14.13.01.01	mitotic cell cycle;mitotic cell cycle and cell cycle control;modification by ubiquitination, deubiquitination;proteasomal degradation (ubiquitin/proteasomal pathway)	17409098	None	Overexpression of p27 in certain cancer cells prevents DNA replication and tumor formation in nude mice, whereas the loss of p27 has been reported in many human cancers and predicts a poor prognosis in breast, prostate, colon, gastric, lung, and esophageal cancers. In several types of cancers, there is a strong correlation between the loss of p27 and induction of Skp2, a subunit of the SCFSkp2/Cks1 (Skp1, Cul1, Roc1, Skp2, Cks1 complex) ubiquitin E3 ligase that targets p27 for ubiquitination and degradation.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cyclin-dependent kinases regulatory subunit 1;E3 ubiquitin-protein ligase RBX1;S-phase kinase-associated protein 1;S-phase kinase-associated protein 2;Cullin-1	CKS1B;RBX1;SKP1;SKP2;CUL1	CKS1;RNF75 ROC1;EMC19 OCP2 SKP1A TCEB1L;FBXL1;None
3038	SMAD2-SMAD4-FAST1 complex	Human	None	None	O75593;Q13485;Q15796	8928;4089;4087	MI:0007-anti tag coimmunoprecipitation	GO:0045893;GO:0003677;GO:0007179;GO:0005634	positive regulation of DNA-templated transcription;DNA binding;transforming growth factor beta receptor signaling pathway;nucleus	11.02.03.04.01;16.03.01;30.05.01.18.01;70.10	transcription activation;DNA binding;TGF-beta-receptor signalling pathway;nucleus	9389648	This complex is built only in the presence of TGF-beta signaling.	SMAD4 is involved in pancreatic carcinoma.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Forkhead box protein H1;Mothers against decapentaplegic homolog 4;Mothers against decapentaplegic homolog 2	FOXH1;SMAD4;SMAD2	FAST1 FAST2;DPC4 MADH4;MADH2 MADR2
3039	SMAD2-FAST1 complex	Human	None	None	O75593;Q15796	8928;4087	MI:0007-anti tag coimmunoprecipitation	GO:0003677;GO:0007179;GO:0005634	DNA binding;transforming growth factor beta receptor signaling pathway;nucleus	16.03.01;30.05.01.18.01;70.10	DNA binding;TGF-beta-receptor signalling pathway;nucleus	9389648	TGF-beta induces formation of the SMAD2-FAST1 complex.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Forkhead box protein H1;Mothers against decapentaplegic homolog 2	FOXH1;SMAD2	FAST1 FAST2;MADH2 MADR2
3040	Multisynthetase complex	Human	Aminoacyl tRNAsynthetase multienzyme complex	None	O43324;P07814;P14868;P41252;P47897;P54136;P56192;Q12904;Q13155;Q15046;Q9P2J5	9521;2058;1615;3376;5859;5917;4141;9255;7965;3735;51520	MI:0028-cosedimentation in solution;MI:0226-ion exchange chromatography	GO:0004812;GO:0005737;GO:0005634	aminoacyl-tRNA ligase activity;cytoplasm;nucleus	12.10;70.03;70.10	aminoacyl-tRNA-synthetases;cytoplasm;nucleus	16169847	The characteristic "core" complex of aminoacyl tRNAsynthetase in higher eukaryotes is composed of nine synthetase activities. These are specific for arginine, aspartate, glutamate, glutamine, isoleucine, leucine, lysine, methionine, and proline. There are also three auxiliary proteins in the multisynthetase complex: p43, p38, and p18. These are involved in protein-protein interactions within the particle and with other protein synthesis factors.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Eukaryotic translation elongation factor 1 epsilon-1;Bifunctional glutamate/proline--tRNA ligase;Aspartate--tRNA ligase, cytoplasmic;Isoleucine--tRNA ligase, cytoplasmic;Glutamine--tRNA ligase;Arginine--tRNA ligase, cytoplasmic;Methionine--tRNA ligase, cytoplasmic;Aminoacyl tRNA synthase complex-interacting multifunctional protein 1;Aminoacyl tRNA synthase complex-interacting multifunctional protein 2;Lysine--tRNA ligase;Leucine--tRNA ligase, cytoplasmic	EEF1E1;EPRS1;DARS1;IARS1;QARS1;RARS1;MARS1;AIMP1;AIMP2;KARS1;LARS1	AIMP3 P18;EPRS GLNS PARS QARS QPRS;DARS;IARS;QARS;RARS;MARS;EMAP2 SCYE1;JTV1;KARS KIAA0070;KIAA1352 LARS
3041	TGF-beta-receptor type II homodimer complex	Human	None	HEK293 cells	P37173	7048	MI:0007-anti tag coimmunoprecipitation	GO:0005515;GO:0007179;GO:0005886	protein binding;transforming growth factor beta receptor signaling pathway;plasma membrane	16.01;30.05.01.18.01;70.02	protein binding;TGF-beta-receptor signalling pathway;eukaryotic plasma membrane / membrane attached	7521335	TGF-beta receptor type II forms a homomeric complex in the absence of the ligand TGF-beta.	None	None	Homo sapiens (Human)	TGF-beta receptor type-2	TGFBR2	None
3043	BMP2-BRIA complex	Human	None	None	P12643;P12644;P36894	650;652;657	MI:0071-molecular sieving	GO:0007179;GO:0051216;GO:0001503;GO:0030316;GO:0030509	transforming growth factor beta receptor signaling pathway;cartilage development;ossification;osteoclast differentiation;BMP signaling pathway	30.05.01.18.01;45.03.05.05;41.05.17;45.03.05.07	TGF-beta-receptor signalling pathway;cartilage;osteogenesis;bone	10881198	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Bone morphogenetic protein 2;Bone morphogenetic protein 4;Bone morphogenetic protein receptor type-1A	BMP2;BMP4;BMPR1A	BMP2A;BMP2B DVR4;ACVRLK3 ALK3
3044	SKI-NCOR1-SIN3A-HDAC1 complex	Human	None	None	O75376;P12755;Q13547;Q96ST3	9611;6497;3065;25942	MI:0006-anti bait coimmunoprecipitation	GO:0006265;GO:0045892;GO:0006476;GO:0003677;GO:0051276;GO:0005634	DNA topological change;negative regulation of DNA-templated transcription;protein deacetylation;DNA binding;chromosome organization;nucleus	10.01.09.05;11.02.03.04.03;14.07.04;16.03.01;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription repression;modification by acetylation, deacetylation;DNA binding;organization of chromosome structure;nucleus	10049357	The oncogenic form of Ski, v-Ski, which lacks the mSin3A binding domain, abrogates transcriptional repression.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Nuclear receptor corepressor 1;Ski oncogene;Histone deacetylase 1;Paired amphipathic helix protein Sin3a	NCOR1;SKI;HDAC1;SIN3A	KIAA1047;None;RPD3L1;None
3045	hs4 enhancer complex (faster migrating complex)	Human	None	B-cell	P09086;P14859;P19838;P25490;Q04206	5452;5451;4790;7528;5970	MI:0412-electrophoretic mobility supershift assay	GO:2001141;GO:0006355;GO:0003677;GO:0007249;GO:0030183;GO:0005634	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;DNA binding;I-kappaB kinase/NF-kappaB signaling;B cell differentiation;nucleus	11.02.03.04;16.03.01;30.01.05.01.04;43.03.07.02.01.01;70.10	transcriptional control;DNA binding;NIK-I-kappaB/NF-kappaB cascade;B-cell;nucleus	14707079	This complex exists in healthy and malignant B-cell lines.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	POU domain, class 2, transcription factor 2;POU domain, class 2, transcription factor 1;Nuclear factor NF-kappa-B p105 subunit;Transcriptional repressor protein YY1;Transcription factor p65	POU2F2;POU2F1;NFKB1;YY1;RELA	OCT2 OTF2;OCT1 OTF1;None;INO80S;NFKB3
3046	hs4 enhancer complex (slow migrating complex)	Human	None	B-cell	P25490;Q01201	7528;5971	MI:0006-anti bait coimmunoprecipitation;MI:0402-chromatin immunoprecipitation assay;MI:0412-electrophoretic mobility supershift assay	GO:2001141;GO:0006355;GO:0003677;GO:0007249;GO:0043066;GO:0030183;GO:0005634	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;DNA binding;I-kappaB kinase/NF-kappaB signaling;negative regulation of apoptotic process;B cell differentiation;nucleus	11.02.03.04;16.03.01;30.01.05.01.04;40.10.02.01;43.03.07.02.01.01;70.10	transcriptional control;DNA binding;NIK-I-kappaB/NF-kappaB cascade;anti-apoptosis;B-cell;nucleus	14707079	None	This complex was observed only in patients with diffuse large B cell lymphoma (DLBCA).	None	Homo sapiens (Human);Homo sapiens (Human)	Transcriptional repressor protein YY1;Transcription factor RelB	YY1;RELB	INO80S;None
3048	mSin3A corepressor complex	Human	mSin3A complex	U937 cells, Jurkat T cells	Q09028;Q13547;Q16576;Q92769;Q96ST3	5928;3065;5931;3066;25942	MI:0006-anti bait coimmunoprecipitation	GO:0006265;GO:0045892;GO:0006476;GO:0003677;GO:0051276;GO:0005634;GO:0016575	DNA topological change;negative regulation of DNA-templated transcription;protein deacetylation;DNA binding;chromosome organization;nucleus;histone deacetylation	10.01.09.05;11.02.03.04.03;14.07.04;16.03.01;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription repression;modification by acetylation, deacetylation;DNA binding;organization of chromosome structure;nucleus	9150133	None	None	Three other subunits of the complex were found in the analysis, which have not been further characterized: p250, p180, p30.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone-binding protein RBBP4;Histone deacetylase 1;Histone-binding protein RBBP7;Histone deacetylase 2;Paired amphipathic helix protein Sin3a	RBBP4;HDAC1;RBBP7;HDAC2;SIN3A	RBAP48;RPD3L1;RBAP46;None;None
3051	MAD-MAX complex	Human	None	None	P61244;Q05195	4149;4084	MI:0006-anti bait coimmunoprecipitation	GO:0045892;GO:0003677;GO:0005634	negative regulation of DNA-templated transcription;DNA binding;nucleus	11.02.03.04.03;16.03.01;70.10	transcription repression;DNA binding;nucleus	8224841	Cell differentiation is accompanied by a change from MYC-MAX complexes (undifferentiated cells) to MAD-MAX complexes (differentiated cells). The ability of MAD to compete with MYC for binding to MAX and to repress MYC transcriptional activation suggests that MAD opposes the function of MYC.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Protein max;Max dimerization protein 1	MAX;MXD1	BHLHD4;MAD
3052	MYC-MAX complex	Human	None	None	P01106;P61244	4609;4149	MI:0006-anti bait coimmunoprecipitation	GO:0045893;GO:0003677;GO:0005634	positive regulation of DNA-templated transcription;DNA binding;nucleus	11.02.03.04.01;16.03.01;70.10	transcription activation;DNA binding;nucleus	8224841	Cell differentiation is accompanied by a change from MYC-MAX complexes (undifferentiated cells) to MAD-MAX complexes (differentiated cells). The ability of MAD to compete with MYC for binding to MAX and to repress MYC transcriptional activation suggests that MAD opposes the function of MYC.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Myc proto-oncogene protein;Protein max	MYC;MAX	BHLHE39;BHLHD4
3053	mSin3A-HDAC1-HDAC2 complex	Human	None	None	Q13547;Q92769;Q96ST3	3065;3066;25942	MI:0006-anti bait coimmunoprecipitation	GO:0006265;GO:0045892;GO:0006476;GO:0051276;GO:0005634	DNA topological change;negative regulation of DNA-templated transcription;protein deacetylation;chromosome organization;nucleus	10.01.09.05;11.02.03.04.03;14.07.04;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription repression;modification by acetylation, deacetylation;organization of chromosome structure;nucleus	9150134	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone deacetylase 1;Histone deacetylase 2;Paired amphipathic helix protein Sin3a	HDAC1;HDAC2;SIN3A	RPD3L1;None;None
3054	MAD1-mSin3A-HDAC2 complex	Human	None	None	Q05195;Q92769;Q96ST3	4084;3066;25942	MI:0007-anti tag coimmunoprecipitation	GO:0006265;GO:2001141;GO:0006355;GO:0006476;GO:0051276;GO:0005634	DNA topological change;regulation of RNA biosynthetic process;regulation of DNA-templated transcription;protein deacetylation;chromosome organization;nucleus	10.01.09.05;11.02.03.04;14.07.04;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcriptional control;modification by acetylation, deacetylation;organization of chromosome structure;nucleus	9150134	MAD-MAX complex functions as transcriptional repressor by recruiting the mSin3A-HDAC complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Max dimerization protein 1;Histone deacetylase 2;Paired amphipathic helix protein Sin3a	MXD1;HDAC2;SIN3A	MAD;None;None
3055	Nop56p-associated pre-rRNA complex	Human	Nop56p-associated pre-ribosomal ribonucleoprotein complex	None	O00567;O76021;P05141;P05386;P05387;P05388;P06748;P08708;P09651;P11387;P13639;P15880;P16402;P18077;P18124;P18621;P19338;P22087;P25398;P26368;P26373;P27635;P30050;P32969;P35268;P36578;P37108;P39023;P40429;P42766;P46776;P46777;P46778;P46779;P46781;P47914;P49411;P50914;P52272;P55209;P55769;P61247;P61254;P61313;P61353;P61513;P62081;P62241;P62244;P62249;P62263;P62266;P62269;P62273;P62277;P62280;P62424;P62736;P62750;P62753;P62829;P62841;P62847;P62888;P62891;P62899;P62906;P62910;P62913;P62917;P63267;P67809;P68104;P83731;P83881;P84098;Q00839;Q01081;Q02543;Q02878;Q07020;Q08211;Q12905;Q12906;Q13428;Q13610;Q14978;Q6P3W7;Q71U36;Q8TDN6;Q92522;Q96SB4;Q99848;Q99879;Q9BQG0;Q9BVP2;Q9H4B7;Q9NR30;Q9NW13;Q9NX58;Q9NZI8;Q9Y2X3;Q9Y383;Q9Y3U8	10528;26156;292;6176;6181;6175;4869;6218;3178;7150;1938;6187;3007;6165;6129;6139;4691;2091;6206;11338;6137;6134;6136;6133;6146;6124;6727;6122;23521;11224;6157;6125;6144;6158;6203;6159;7284;9045;4670;4673;4809;6189;6154;6138;6155;6168;6201;6202;6210;6217;6208;6228;6222;6235;6207;6205;6130;59;6147;6194;9349;6209;6229;6156;6170;6160;4736;6161;6135;6132;72;4904;1915;6152;6173;6143;3192;7307;6142;6128;6141;1660;3608;3609;6949;11137;9221;55681;7846;55299;8971;6732;10969;8342;10514;26354;81027;9188;55131;55646;10642;51602;51631;25873	MI:0007-anti tag coimmunoprecipitation;MI:0069-mass spectrometry studies of complexes	GO:0042254;GO:0005634	ribosome biogenesis;nucleus	12.01;70.10	ribosome biogenesis;nucleus	12777385	Identification of pre-rRNA species within hNop56p-associated pre-ribosomal ribonucleoprotein complexes, coupled with the known functions of yeast orthologs of the probable trans-acting factors identified in man, demonstrated that hNop56p functions in the early to middle stages of 60 S subunit synthesis.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Nucleolar protein 56;Ribosomal L1 domain-containing protein 1;ADP/ATP translocase 2;60S acidic ribosomal protein P1;60S acidic ribosomal protein P2;60S acidic ribosomal protein P0;Nucleophosmin;40S ribosomal protein S17;Heterogeneous nuclear ribonucleoprotein A1;DNA topoisomerase 1;Elongation factor 2;40S ribosomal protein S2;Histone H1.3;60S ribosomal protein L35a;60S ribosomal protein L7;60S ribosomal protein L17;Nucleolin;rRNA 2'-O-methyltransferase fibrillarin;40S ribosomal protein S12;Splicing factor U2AF 65 kDa subunit;60S ribosomal protein L13;60S ribosomal protein L10;60S ribosomal protein L12;60S ribosomal protein L9;60S ribosomal protein L22;60S ribosomal protein L4;Signal recognition particle 14 kDa protein;60S ribosomal protein L3;60S ribosomal protein L13a;60S ribosomal protein L35;60S ribosomal protein L27a;60S ribosomal protein L5;60S ribosomal protein L21;60S ribosomal protein L28;40S ribosomal protein S9;60S ribosomal protein L29;Elongation factor Tu, mitochondrial;60S ribosomal protein L14;Heterogeneous nuclear ribonucleoprotein M;Nucleosome assembly protein 1-like 1;NHP2-like protein 1;40S ribosomal protein S3a;60S ribosomal protein L26;60S ribosomal protein L15;60S ribosomal protein L27;60S ribosomal protein L37a;40S ribosomal protein S7;40S ribosomal protein S8;40S ribosomal protein S15a;40S ribosomal protein S16;40S ribosomal protein S14;40S ribosomal protein S23;40S ribosomal protein S18;40S ribosomal protein S29;40S ribosomal protein S13;40S ribosomal protein S11;60S ribosomal protein L7a;Actin, aortic smooth muscle;60S ribosomal protein L23a;40S ribosomal protein S6;60S ribosomal protein L23;40S ribosomal protein S15;40S ribosomal protein S24;60S ribosomal protein L30;60S ribosomal protein L39;60S ribosomal protein L31;60S ribosomal protein L10a;60S ribosomal protein L32;60S ribosomal protein L11;60S ribosomal protein L8;Actin, gamma-enteric smooth muscle;Y-box-binding protein 1;Elongation factor 1-alpha 1;60S ribosomal protein L24;60S ribosomal protein L36a;60S ribosomal protein L19;Heterogeneous nuclear ribonucleoprotein U;Splicing factor U2AF 35 kDa subunit;60S ribosomal protein L18a;60S ribosomal protein L6;60S ribosomal protein L18;ATP-dependent RNA helicase A;Interleukin enhancer-binding factor 2;Interleukin enhancer-binding factor 3;Treacle protein;Periodic tryptophan protein 1 homolog;Nucleolar and coiled-body phosphoprotein 1;SCY1-like protein 2;Tubulin alpha-1A chain;Ribosome biogenesis protein BRX1 homolog;Histone H1.10;SRSF protein kinase 1;Probable rRNA-processing protein EBP2;Histone H2B type 1-M;Myb-binding protein 1A;Guanine nucleotide-binding protein-like 3;Tubulin beta-1 chain;Nucleolar RNA helicase 2;RNA-binding protein 28;Cell growth-regulating nucleolar protein;Insulin-like growth factor 2 mRNA-binding protein 1;Nucleolar protein 58;Putative RNA-binding protein Luc7-like 2;60S ribosomal protein L36	NOP56;RSL1D1;SLC25A5;RPLP1;RPLP2;RPLP0;NPM1;RPS17;HNRNPA1;TOP1;EEF2;RPS2;H1-3;RPL35A;RPL7;RPL17;NCL;FBL;RPS12;U2AF2;RPL13;RPL10;RPL12;RPL9;RPL22;RPL4;SRP14;RPL3;RPL13A;RPL35;RPL27A;RPL5;RPL21;RPL28;RPS9;RPL29;TUFM;RPL14;HNRNPM;NAP1L1;SNU13;RPS3A;RPL26;RPL15;RPL27;RPL37A;RPS7;RPS8;RPS15A;RPS16;RPS14;RPS23;RPS18;RPS29;RPS13;RPS11;RPL7A;ACTA2;RPL23A;RPS6;RPL23;RPS15;RPS24;RPL30;RPL39;RPL31;RPL10A;RPL32;RPL11;RPL8;ACTG2;YBX1;EEF1A1;RPL24;RPL36A;RPL19;HNRNPU;U2AF1;RPL18A;RPL6;RPL18;DHX9;ILF2;ILF3;TCOF1;PWP1;NOLC1;SCYL2;TUBA1A;BRIX1;H1-10;SRPK1;EBNA1BP2;H2BC14;MYBBP1A;GNL3;TUBB1;DDX21;RBM28;LYAR;IGF2BP1;NOP58;LUC7L2;RPL36	NOL5A;CATX11 CSIG PBK1;AAC2 ANT2;RRP1;D11S2243E RPP2;None;NPM;RPS17L;HNRPA1;None;EF2;RPS4;H1F3 HIST1H1D;None;None;None;None;FIB1 FLRN;None;U2AF65;BBC1;DXS648E QM;None;None;None;RPL1;None;None;None;None;None;None;None;None;None;None;None;None;HNRPM NAGR1;NRP;NHP2L1;FTE1 MFTL;None;EC45;None;None;None;None;None;None;None;None;D6S218E;None;None;None;SURF-3 SURF3;ACTSA ACTVS;None;None;None;RIG;None;None;None;None;NEDD6;None;None;None;ACTA3 ACTL3 ACTSG;NSEP1 YB1;EEF1A EF1A LENG7;None;RPL44;None;C1orf199 HNRPU SAFA U21.1;U2AF35 U2AFBP;None;TXREB1;None;DDX9 LKP NDH2;NF45;DRBF MPHOSPH4 NF90;None;None;KIAA0035 NS5ATP13;CVAK104 KIAA1360;TUBA3;BRIX BXDC2;H1FX;None;EBP2;H2BFE HIST1H2BM;P160;E2IG3 NS;None;None;None;;CRDBP VICKZ1 ZBP1;NOL5 NOP5;None;None
3056	Microprocessor complex	Human	small Drosha complex (DGCR8-DROSHA)	HEK293 cells	Q8WYQ5;Q9NRR4	54487;29102	MI:0007-anti tag coimmunoprecipitation;MI:0071-molecular sieving	GO:0006396;GO:0003723;GO:0005634	RNA processing;RNA binding;nucleus	11.04;16.03.03;70.10	RNA processing;RNA binding;nucleus	15531877	This complex is responsible for pre-miRNA processing.	DGCR8 is deleted in DiGeorge syndrome.	None	Homo sapiens (Human);Homo sapiens (Human)	Microprocessor complex subunit DGCR8;Ribonuclease 3	DGCR8;DROSHA	C22orf12 DGCRK6;RN3 RNASE3L RNASEN
3057	ITGA10-ITGB1 complex	Human	alpha10-beta1 integrin complex	chondrocyte cells	O75578;P05556	8515;3688	MI:0004-affinity chromatography technology;MI:0019-coimmunoprecipitation	GO:0051211;GO:0008305;GO:0007155	anisotropic cell growth;integrin complex;cell adhesion	40.01.03;34.07	directional cell growth (morphogenesis);cell adhesion	9685391	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Integrin alpha-10;Integrin beta-1	ITGA10;ITGB1	None;FNRB, MDF2, MSK12
3058	ITGA11-ITGB1 complex	Human	alpha11-beta1 integrin complex	XXVI muscle cells	P05556;Q9UKX5	3688;22801	MI:0019-coimmunoprecipitation	GO:0005515;GO:0016477;GO:0008305;GO:0007155	protein binding;cell migration;integrin complex;cell adhesion	16.01;34.05.01;34.07	protein binding;cell migration;cell adhesion	10464311	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-1;Integrin alpha-11	ITGB1;ITGA11	FNRB, MDF2, MSK12;None
3059	ITGA11-ITGB1-COL1A1 complex	Human	integrin complex	None	P02452;P05556;Q9UKX5	1277;3688;22801	MI:0004-affinity chromatography technology;MI:0019-coimmunoprecipitation	GO:0007229	integrin-mediated signaling pathway	30.05.02.26	integrin receptor signalling pathway	10464311	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Collagen alpha-1(I) chain;Integrin beta-1;Integrin alpha-11	COL1A1;ITGB1;ITGA11	None;FNRB, MDF2, MSK12;None
3060	RNA polymerase II complex (RPB1, RAP74, CDK8, CYCC, SRB7, BAF190, BAF47), chromatin structure modifying	Human	None	HeLa cells	P24863;P24928;P35269;P49336;P51531;Q12824;Q13503	892;5430;2962;1024;6595;6598;9412	MI:0047-far western blotting	GO:0006265;GO:0006351;GO:0003677;GO:0005634	DNA topological change;DNA-templated transcription;DNA binding;nucleus	10.01.09.05;11;16.03.01;70.10	DNA conformation modification (e.g. chromatin);TRANSCRIPTION;DNA binding;nucleus	9710619	RNA polymerase II complex contains chromatin structure remodeling activity and histone acetyltransferase activity. Notably, the general transcription factors are absent from this complex.	None	Since the authors did not specify SNF2 (= SMARCA), we used isoform SNF2A (=SMARCA2).	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cyclin-C;DNA-directed RNA polymerase II subunit RPB1;General transcription factor IIF subunit 1;Cyclin-dependent kinase 8;Probable global transcription activator SNF2L2;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1;Mediator of RNA polymerase II transcription subunit 21	CCNC;POLR2A;GTF2F1;CDK8;SMARCA2;SMARCB1;MED21	None;POLR2;RAP74;None;BAF190B BRM SNF2A SNF2L2;BAF47, INI1, SNF5L1;SRB7 SURB7
3061	RNA polymerase II complex (CBP, PCAF, RPB1, BAF47, CYCC, CDK8), chromatin structure modifying	Human	None	HeLa cells	P24863;P24928;P49336;Q12824;Q92793;Q92831	892;5430;1024;6598;1387;8850	MI:0226-ion exchange chromatography	GO:0006265;GO:0006351;GO:0003677;GO:0005634	DNA topological change;DNA-templated transcription;DNA binding;nucleus	10.01.09.05;11;16.03.01;70.10	DNA conformation modification (e.g. chromatin);TRANSCRIPTION;DNA binding;nucleus	9710619	RNA polymerase II complex contains chromatin structure remodeling activity and histone acetyltransferase activity.Notably, the general transcription factors are absent from this complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cyclin-C;DNA-directed RNA polymerase II subunit RPB1;Cyclin-dependent kinase 8;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1;CREB-binding protein;Histone acetyltransferase KAT2B	CCNC;POLR2A;CDK8;SMARCB1;CREBBP;KAT2B	None;POLR2;None;BAF47, INI1, SNF5L1;CBP;PCAF
3062	RNA polymerase II complex, (CBP, RPBI, PCAF, BAF47), chromatin structure modifying	Human	None	HeLa cells	P24928;Q12824;Q92793;Q92831	5430;6598;1387;8850	MI:0019-coimmunoprecipitation;MI:0047-far western blotting	GO:0006265;GO:0006351;GO:0003677;GO:0005634	DNA topological change;DNA-templated transcription;DNA binding;nucleus	10.01.09.05;11;16.03.01;70.10	DNA conformation modification (e.g. chromatin);TRANSCRIPTION;DNA binding;nucleus	9710619	RNA polymerase II complex contains chromatin structure remodeling activity and histone acetyltransferase activity.Notably, the general transcription factors are absent from this complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA-directed RNA polymerase II subunit RPB1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1;CREB-binding protein;Histone acetyltransferase KAT2B	POLR2A;SMARCB1;CREBBP;KAT2B	POLR2;BAF47, INI1, SNF5L1;CBP;PCAF
3063	Brg1-associated complex II	Human	None	None	O14497;O14744;O96019;P51532;Q12824;Q8TAQ2;Q92922	8289;10419;86;6597;6598;6601;6599	MI:0007-anti tag coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0006265;GO:2001141;GO:0006355;GO:0003677;GO:0051276;GO:0005634	DNA topological change;regulation of RNA biosynthetic process;regulation of DNA-templated transcription;DNA binding;chromosome organization;nucleus	10.01.09.05;11.02.03.04;16.03.01;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcriptional control;DNA binding;organization of chromosome structure;nucleus	11238380	None	None	In a following paper (PMID:14559996) p66 has been identified as PRMT5.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	AT-rich interactive domain-containing protein 1A;Protein arginine N-methyltransferase 5;Actin-like protein 6A;Transcription activator BRG1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1;SWI/SNF complex subunit SMARCC2;SWI/SNF complex subunit SMARCC1	ARID1A;PRMT5;ACTL6A;SMARCA4;SMARCB1;SMARCC2;SMARCC1	BAF250 BAF250A C1orf4 OSA1 SMARCF1;HRMT1L5 IBP72 JBP1 SKB1;BAF53 BAF53A INO80K;BAF190A BRG1 SNF2B SNF2L4;BAF47, INI1, SNF5L1;BAF170;BAF155
3064	RNA polymerase II complex, chromatin structure modifying	Human	None	HeLa cells	P20226;P24863;P24928;P29083;P32780;P35269;P49336;P51531;Q00403;Q12824;Q13503;Q14919;Q6UW60;Q8TAQ2;Q92922;Q96GM5	6908;892;5430;2960;2965;2962;1024;6595;2959;6598;9412;10589;54760;6601;6599;6602	MI:0004-affinity chromatography technology	GO:0006265;GO:0006351;GO:0003677;GO:0005634	DNA topological change;DNA-templated transcription;DNA binding;nucleus	10.01.09.05;11;16.03.01;70.10	DNA conformation modification (e.g. chromatin);TRANSCRIPTION;DNA binding;nucleus	9710619	RNA polymerase II complex contains chromatin structure remodeling activity and histone acetyltransferase activity.Notably, the general transcription factors are absent from this complex.	None	Since the authors did not specify SNF2 (= SMARCA) and BAF60 (=SMARCD), we used isoform SNF2A (=SMARCA2) and BAF60A (=SMARCD1).	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	TATA-box-binding protein;Cyclin-C;DNA-directed RNA polymerase II subunit RPB1;General transcription factor IIE subunit 1;General transcription factor IIH subunit 1;General transcription factor IIF subunit 1;Cyclin-dependent kinase 8;Probable global transcription activator SNF2L2;Transcription initiation factor IIB;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1;Mediator of RNA polymerase II transcription subunit 21;Dr1-associated corepressor;Proprotein convertase subtilisin/kexin type 4;SWI/SNF complex subunit SMARCC2;SWI/SNF complex subunit SMARCC1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1	TBP;CCNC;POLR2A;GTF2E1;GTF2H1;GTF2F1;CDK8;SMARCA2;GTF2B;SMARCB1;MED21;DRAP1;PCSK4;SMARCC2;SMARCC1;SMARCD1	GTF2D1 TF2D TFIID;None;POLR2;TF2E1;BTF2;RAP74;None;BAF190B BRM SNF2A SNF2L2;TF2B TFIIB;BAF47, INI1, SNF5L1;SRB7 SURB7;None;PC4;BAF170;BAF155;BAF60A
3065	RNA polymerase II complex, chromatin structure modifying	Human	None	HeLa cells	O96019;P24863;P49336;Q12824;Q13503;Q8TAQ2;Q92922;Q969G3;Q96GM5	86;892;1024;6598;9412;6601;6599;6605;6602	MI:0047-far western blotting	GO:0006265;GO:0006351;GO:0003677;GO:0005634	DNA topological change;DNA-templated transcription;DNA binding;nucleus	10.01.09.05;11;16.03.01;70.10	DNA conformation modification (e.g. chromatin);TRANSCRIPTION;DNA binding;nucleus	9710619	RNA polymerase II complex contains chromatin structure remodeling activity and histone acetyltransferase activity. Notably, the general transcription factors are absent from this complex.	None	Since the authors did not specify BAF60, we used isoform BAF60A.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Actin-like protein 6A;Cyclin-C;Cyclin-dependent kinase 8;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1;Mediator of RNA polymerase II transcription subunit 21;SWI/SNF complex subunit SMARCC2;SWI/SNF complex subunit SMARCC1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1	ACTL6A;CCNC;CDK8;SMARCB1;MED21;SMARCC2;SMARCC1;SMARCE1;SMARCD1	BAF53 BAF53A INO80K;None;None;BAF47, INI1, SNF5L1;SRB7 SURB7;BAF170;BAF155;BAF57;BAF60A
3066	RNA polymerase II complex, chromatin structure modifying	Human	None	HeLa cells	P19447;P24863;P24928;P35269;P49336;P51531;P51532;Q00403;Q12824;Q13503;Q13889;Q92793;Q92831	2071;892;5430;2962;1024;6595;6597;2959;6598;9412;2967;1387;8850	MI:0047-far western blotting;MI:0226-ion exchange chromatography	GO:0006265;GO:0006351;GO:0003677;GO:0005634	DNA topological change;DNA-templated transcription;DNA binding;nucleus	10.01.09.05;11;16.03.01;70.10	DNA conformation modification (e.g. chromatin);TRANSCRIPTION;DNA binding;nucleus	9710619	RNA polymerase II complex contains chromatin structure remodeling activity and histone acetyltransferase activity. Notably, the general transcription factors are absent from this complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	General transcription and DNA repair factor IIH helicase subunit XPB;Cyclin-C;DNA-directed RNA polymerase II subunit RPB1;General transcription factor IIF subunit 1;Cyclin-dependent kinase 8;Probable global transcription activator SNF2L2;Transcription activator BRG1;Transcription initiation factor IIB;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1;Mediator of RNA polymerase II transcription subunit 21;General transcription factor IIH subunit 3;CREB-binding protein;Histone acetyltransferase KAT2B	ERCC3;CCNC;POLR2A;GTF2F1;CDK8;SMARCA2;SMARCA4;GTF2B;SMARCB1;MED21;GTF2H3;CREBBP;KAT2B	XPB XPBC;None;POLR2;RAP74;None;BAF190B BRM SNF2A SNF2L2;BAF190A BRG1 SNF2B SNF2L4;TF2B TFIIB;BAF47, INI1, SNF5L1;SRB7 SURB7;None;CBP;PCAF
3067	RNA polymerase II complex, (CDK8 complex), chromatin structure modifying	Human	None	HeLa cells	P24863;P35269;P49336;P51946;Q12824;Q13503;Q8TAQ2;Q92922	892;2962;1024;902;6598;9412;6601;6599	MI:0047-far western blotting	GO:0006265;GO:0006351;GO:0003677;GO:0005634	DNA topological change;DNA-templated transcription;DNA binding;nucleus	10.01.09.05;11;16.03.01;70.10	DNA conformation modification (e.g. chromatin);TRANSCRIPTION;DNA binding;nucleus	9710619	RNA polymerase II complex contains chromatin structure remodeling activity and histone acetyltransferase activity.Notably, the general transcription factors are absent from this complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cyclin-C;General transcription factor IIF subunit 1;Cyclin-dependent kinase 8;Cyclin-H;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1;Mediator of RNA polymerase II transcription subunit 21;SWI/SNF complex subunit SMARCC2;SWI/SNF complex subunit SMARCC1	CCNC;GTF2F1;CDK8;CCNH;SMARCB1;MED21;SMARCC2;SMARCC1	None;RAP74;None;None;BAF47, INI1, SNF5L1;SRB7 SURB7;BAF170;BAF155
3070	CTF18-cohesion-RFC-POLH complex	Human	None	None	P0CG13;P35249;P35250;P40937;P40938;Q8WVB6;Q9BVC3;Q9Y253	54921;5984;5982;5985;5983;63922;79075;5429	MI:0004-affinity chromatography technology;MI:0019-coimmunoprecipitation;MI:0027-cosedimentation	GO:0006260;GO:0006310;GO:0006281;GO:0003677;GO:0005634	DNA replication;DNA recombination;DNA repair;DNA binding;nucleus	10.01.03;10.01.05.03;10.01.05.01;16.03.01;70.10	DNA synthesis and replication;DNA recombination;DNA repair;DNA binding;nucleus	17545166	The interaction of CTF18-cohesion-RFC complex  with  DNA-polymerase eta allows DNA replication fork to overcome interference by various template structures, including damaged DNA and DNA-protein complexes that maintain chromosome cohesion.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Chromosome transmission fidelity protein 8 homolog;Replication factor C subunit 4;Replication factor C subunit 2;Replication factor C subunit 5;Replication factor C subunit 3;Chromosome transmission fidelity protein 18 homolog;Sister chromatid cohesion protein DCC1;DNA polymerase eta	CHTF8;RFC4;RFC2;RFC5;RFC3;CHTF18;DSCC1;POLH	CTF8;None;None;None;None;C16orf41 CTF18;DCC1;RAD30 RAD30A XPV
3071	CTLH complex, 20S	Human	RANBPM-MKLN1-MAEA-RMND5A-ARMC8 complex	None	Q7L5Y9;Q8IUR7;Q96S59;Q9H871;Q9UL63	10296;25852;10048;64795;4289	MI:0019-coimmunoprecipitation	GO:0007059;GO:0016477;GO:0000226;GO:0005737;GO:0005634	chromosome segregation;cell migration;microtubule cytoskeleton organization;cytoplasm;nucleus	10.03.04.05;34.05.01;42.04.05;70.03;70.10	chromosome segregation/division;cell migration;microtubule cytoskeleton;cytoplasm;nucleus	17467196	This complex might be involved in the regulation of microtubule dynamics, cell migration , nucleokinesis and chromosome segregation.CTHL complex contains alpha and beta splice variants of ARMC8.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein transferase MAEA;Armadillo repeat-containing protein 8;Ran-binding protein 9;E3 ubiquitin-protein transferase RMND5A;Muskelin	MAEA;ARMC8;RANBP9;RMND5A;MKLN1	EMP;None;RANBPM;None;None
3075	UTX-MLL2/3 complex	Human	None	HEK293 cells	O14686;O15550;P61964;Q14686;Q15291;Q5H9R7;Q6ZW49;Q86UW6;Q86XN7;Q8NEZ4;Q9UBL3;Q9Y2X9	8085;7403;11091;23054;5929;55291;22976;55728;80209;58508;9070;23528	MI:0007-anti tag coimmunoprecipitation	GO:0045893;GO:0018126;GO:0006479;GO:0005634;GO:0036211	positive regulation of DNA-templated transcription;protein hydroxylation;protein methylation;nucleus;protein modification process	11.02.03.04.01;14.07.09;70.10	transcription activation;posttranslational modification of amino acids (e.g. hydroxylation, methylation);nucleus	17761849	Methylation of histone H3 lysine 27 (H3K27) is a post-translational modification highly correlated with genomic silencing. UTX, a member of JmjC-family proteins, is a di- and trimethyl H3K27 demethylase. Results uncover a concerted mechanism for transcriptional activation in which cycles of H3K4 methylation by MLL2/3 are linked with demethylation of H3K27 through UTX.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone-lysine N-methyltransferase 2D;Lysine-specific demethylase 6A;WD repeat-containing protein 5;Nuclear receptor coactivator 6;Retinoblastoma-binding protein 5;Serine/threonine-protein phosphatase 6 regulatory subunit 3;PAX-interacting protein 1;NEDD4-binding protein 2;Proline and serine-rich protein 1;Histone-lysine N-methyltransferase 2C;Set1/Ash2 histone methyltransferase complex subunit ASH2;Zinc finger protein 281	KMT2D;KDM6A;WDR5;NCOA6;RBBP5;PPP6R3;PAXIP1;N4BP2;PROSER1;KMT2C;ASH2L;ZNF281	ALR MLL2 MLL4;UTX;BIG3;AIB3 KIAA0181 RAP250 TRBP;RBQ3;C11orf23 KIAA1558 PP6R3 SAPL SAPS3;PAXIP1L PTIP;B3BP KIAA1413;C13orf23 KIAA2032;HALR, KIAA1506, MLL3;ASH2L1;GZP1 ZBP99
3078	DGCR8-NCL complex	Human	None	None	P19338;Q8WYQ5	4691;54487	MI:0007-anti tag coimmunoprecipitation;MI:0416-fluorescence microscopy	GO:0006396;GO:0003723;GO:0005730	RNA processing;RNA binding;nucleolus	11.04;16.03.03;70.10.07	RNA processing;RNA binding;nucleolus	17765891	The authors demonstrated that certain RNA may be involved in the interaction between DGCR8 and Nucleolin, and removal of RNA induces dissociation of these two proteins. The results suggest that DGCR8 may be involved in maturation of miRNA at the nucleolus and nucleoplasm with Nucleolin.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Nucleolin;Microprocessor complex subunit DGCR8	NCL;DGCR8	None;C22orf12 DGCRK6
3079	DGCR8-ILF3 complex	Human	None	None	Q12906;Q8WYQ5	3609;54487	MI:0019-coimmunoprecipitation	GO:0006396;GO:0003723;GO:0005730	RNA processing;RNA binding;nucleolus	11.04;16.03.03;70.10.07	RNA processing;RNA binding;nucleolus	17765891	The authors found that ILF3 is associated with both DGCR8 and Exportin5 (XPO5), although DGCR8 is not associated with XPO5.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Interleukin enhancer-binding factor 3;Microprocessor complex subunit DGCR8	ILF3;DGCR8	DRBF MPHOSPH4 NF90;C22orf12 DGCRK6
3080	ILF3-XPO5 complex	Human	None	HEK293FT cells	Q12906;Q9HAV4	3609;57510	MI:0019-coimmunoprecipitation	GO:0005634;GO:0006405;GO:0005737	nucleus;RNA export from nucleus;cytoplasm	70.10;70.03	nucleus;cytoplasm	17765891	Exportin5 (XPO5) is known to bind the hairpin structure of pre-miRNA and exports the processed pre-miRNA to the cytoplasm via nuclear pore.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Interleukin enhancer-binding factor 3;Exportin-5	ILF3;XPO5	DRBF MPHOSPH4 NF90;KIAA1291 RANBP21
3082	DGCR8 multiprotein complex	Human	None	None	O43390;P11021;P17844;P19338;P31943;P35637;Q00839;Q08211;Q12906;Q8WYQ5;Q92841	10236;3309;1655;4691;3187;2521;3192;1660;3609;54487;10521	MI:0007-anti tag coimmunoprecipitation;MI:0416-fluorescence microscopy	GO:0006396;GO:0005634	RNA processing;nucleus	11.04;70.10	RNA processing;nucleus	17765891	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Heterogeneous nuclear ribonucleoprotein R;Endoplasmic reticulum chaperone BiP;Probable ATP-dependent RNA helicase DDX5;Nucleolin;Heterogeneous nuclear ribonucleoprotein H;RNA-binding protein FUS;Heterogeneous nuclear ribonucleoprotein U;ATP-dependent RNA helicase A;Interleukin enhancer-binding factor 3;Microprocessor complex subunit DGCR8;Probable ATP-dependent RNA helicase DDX17	HNRNPR;HSPA5;DDX5;NCL;HNRNPH1;FUS;HNRNPU;DHX9;ILF3;DGCR8;DDX17	HNRPR;GRP78;G17P1 HELR HLR1;None;HNRPH HNRPH1;TLS;C1orf199 HNRPU SAFA U21.1;DDX9 LKP NDH2;DRBF MPHOSPH4 NF90;C22orf12 DGCRK6;None
3084	CCND1-CDK4 complex	Human	None	SaOS-2 cells; U2-OS cells	P11802;P24385	1019;595	MI:0019-coimmunoprecipitation;MI:0047-far western blotting;MI:0416-fluorescence microscopy	GO:0000278;GO:0006468;GO:0005634;GO:0097128	mitotic cell cycle;protein phosphorylation;nucleus;cyclin D1-CDK4 complex	10.03.01.01;14.07.03;70.10	mitotic cell cycle;modification by phosphorylation, dephosphorylation, autophosphorylation;nucleus	9447971	Endogenous D-type cyclins, acting with cdk4/6, are able to phosphorylate pRb only partially, a process that is likely to be completed by cyclin E-cdk2 complexes.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cyclin-dependent kinase 4;G1/S-specific cyclin-D1	CDK4;CCND1	None;BCL1 PRAD1
3085	CCND2-CDK4 complex	Human	None	SaOS-2 cells; U2-OS cells	P11802;P30279	1019;894	MI:0019-coimmunoprecipitation;MI:0047-far western blotting;MI:0416-fluorescence microscopy	GO:0000278;GO:0006468;GO:0005634;GO:0097129	mitotic cell cycle;protein phosphorylation;nucleus;cyclin D2-CDK4 complex	10.03.01.01;14.07.03;70.10	mitotic cell cycle;modification by phosphorylation, dephosphorylation, autophosphorylation;nucleus	9447971	Endogenous D-type cyclins, acting with cdk4/6, are able to phosphorylate pRb only partially, a process that is likely to be completed by cyclin E-cdk2 complexes.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cyclin-dependent kinase 4;G1/S-specific cyclin-D2	CDK4;CCND2	None;None
3086	CCND3-CDK4 complex	Human	None	SaOS-2 cells; U2-OS cells	P11802;P30281	1019;896	MI:0019-coimmunoprecipitation;MI:0047-far western blotting;MI:0416-fluorescence microscopy	GO:0000278;GO:0006468;GO:0005634;GO:0097130	mitotic cell cycle;protein phosphorylation;nucleus;cyclin D3-CDK4 complex	10.03.01.01;14.07.03;70.10	mitotic cell cycle;modification by phosphorylation, dephosphorylation, autophosphorylation;nucleus	9447971	Endogenous D-type cyclins, acting with cdk4/6, are able to phosphorylate pRb only partially, a process that is likely to be completed by cyclin E-cdk2 complexes.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cyclin-dependent kinase 4;G1/S-specific cyclin-D3	CDK4;CCND3	None;None
3087	CCND1-CDK6 complex	Human	None	SaOS-2 cells; U2-OS cells	P24385;Q00534	595;1021	MI:0019-coimmunoprecipitation;MI:0047-far western blotting;MI:0416-fluorescence microscopy	GO:0000278;GO:0006468;GO:0005634;GO:0097131	mitotic cell cycle;protein phosphorylation;nucleus;cyclin D1-CDK6 complex	10.03.01.01;14.07.03;70.10	mitotic cell cycle;modification by phosphorylation, dephosphorylation, autophosphorylation;nucleus	9447971	Endogenous D-type cyclins, acting with cdk4/6, are able to phosphorylate pRb only partially, a process that is likely to be completed by cyclin E-cdk2 complexes.	None	None	Homo sapiens (Human);Homo sapiens (Human)	G1/S-specific cyclin-D1;Cyclin-dependent kinase 6	CCND1;CDK6	BCL1 PRAD1;CDKN6
3088	CCND2-CDK6 complex	Human	None	SaOS-2 cells; U2-OS cells	P30279;Q00534	894;1021	MI:0019-coimmunoprecipitation;MI:0047-far western blotting;MI:0416-fluorescence microscopy	GO:0000278;GO:0006468;GO:0005634;GO:0097132	mitotic cell cycle;protein phosphorylation;nucleus;cyclin D2-CDK6 complex	10.03.01.01;14.07.03;70.10	mitotic cell cycle;modification by phosphorylation, dephosphorylation, autophosphorylation;nucleus	9447971	Endogenous D-type cyclins, acting with cdk4/6, are able to phosphorylate pRb only partially, a process that is likely to be completed by cyclin E-cdk2 complexes.	None	None	Homo sapiens (Human);Homo sapiens (Human)	G1/S-specific cyclin-D2;Cyclin-dependent kinase 6	CCND2;CDK6	None;CDKN6
3089	CCND3-CDK6 complex	Human	None	SaOS-2 cells; U2-OS cells	P30281;Q00534	896;1021	MI:0019-coimmunoprecipitation;MI:0047-far western blotting;MI:0416-fluorescence microscopy	GO:0000278;GO:0006468;GO:0005634;GO:0097133	mitotic cell cycle;protein phosphorylation;nucleus;cyclin D3-CDK6 complex	10.03.01.01;14.07.03;70.10	mitotic cell cycle;modification by phosphorylation, dephosphorylation, autophosphorylation;nucleus	9447971	Endogenous D-type cyclins, acting with cdk4/6, are able to phosphorylate pRb only partially, a process that is likely to be completed by cyclin E-cdk2 complexes.	None	None	Homo sapiens (Human);Homo sapiens (Human)	G1/S-specific cyclin-D3;Cyclin-dependent kinase 6	CCND3;CDK6	None;CDKN6
3092	APP-TOMM40 complex, mitochondrial	Human	APP-TOM40 complex	brain	O96008;P05067	10452;351	MI:0019-coimmunoprecipitation;MI:0040-electron microscopy	GO:0006886;GO:0006605;GO:0015031;GO:0005739;GO:0005741	intracellular protein transport;protein targeting;protein transport;mitochondrion;mitochondrial outer membrane	14.04;20.01.10;70.16;70.16.01	protein targeting, sorting and translocation;protein transport;mitochondrion;mitochondrial outer membrane	16943564	Mitochondrial accumulation of APP is associated with decreased cytochrome c oxidase activity and increased levels of H2O2 in mitochondria. Reduced mitochondrial cytochrome c oxidase activity and increased oxidative stress have been associated with the pathogenesis of AD. In Alzheimer disease brains, mitochondrially associated APP formed stable approximately 480 kDa complexes with the translocase of the outer mitochondrial membrane 40 (TOM40) import channel and a super complex of approximately 620 kDa with both mitochondrial TOM40 and the translocase of the inner mitochondrial membrane 23 (TIM23) import channel TIM23 in an "N(in mitochondria)-C(out cytoplasm)" orientation.	Alzheimer disease	None	Homo sapiens (Human);Homo sapiens (Human)	Mitochondrial import receptor subunit TOM40 homolog;Amyloid-beta precursor protein	TOMM40;APP	C19orf1 PEREC1 TOM40;A4 AD1
3093	APP-TIMM23 complex, mitochondrial	Human	APP-TIM23 complex	brain	O14925;P05067	100287932;351	MI:0019-coimmunoprecipitation;MI:0047-far western blotting	GO:0006886;GO:0006605;GO:0015031;GO:0005739;GO:0005743	intracellular protein transport;protein targeting;protein transport;mitochondrion;mitochondrial inner membrane	14.04;20.01.10;70.16;70.16.05	protein targeting, sorting and translocation;protein transport;mitochondrion;mitochondrial inner membrane	16943564	Mitochondrial accumulation of APP is associated with decreased cytochrome c oxidase activity and increased levels of H2O2 in mitochondria. Reduced mitochondrial cytochrome c oxidase activity and increased oxidative stress have been associated with the pathogenesis of AD. In Alzheimer disease brains, mitochondrially associated APP formed stable approximately 480 kDa complexes with the translocase of the outer mitochondrial membrane 40 (TOM40) import channel and a super complex of approximately 620 kDa with both mitochondrial TOM40 and the translocase of the inner mitochondrial membrane 23 (TIM23) import channel TIM23 in an "N(in mitochondria)-C(out cytoplasm)" orientation.	APP is involved in Alzheimer disease.	None	Homo sapiens (Human);Homo sapiens (Human)	Mitochondrial import inner membrane translocase subunit Tim23;Amyloid-beta precursor protein	TIMM23;APP	TIM23;A4 AD1
3096	ITGA6-ITGB4-SHC1-GRB2 complex	Human	None	epithelium, skin	P16144;P23229;P29353;P62993	3691;3655;6464;2885	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0023052;GO:0007010	signaling;cytoskeleton organization	30.01;42.04	cellular signalling;cytoskeleton/structural proteins	7556090	The signal transduction by the alpha6beta4 integrin is mediated by an associated tyrosine kinase and that phosphorylation of distinct sites in the beta 4 tail mediates assembly of the hemidesmosomal cytoskeleton and recruitment of Shc/Grb2.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-4;Integrin alpha-6;SHC-transforming protein 1;Growth factor receptor-bound protein 2	ITGB4;ITGA6;SHC1;GRB2	None;None;SHC SHCA;ASH
3099	COIL-TIMM50a complex	Human	CLN80-TIM50a complex	HeLa cells	P38432;Q3ZCQ8-2	8161;92609	MI:0018-two hybrid;MI:0051-fluorescence technology;MI:0096-pull down	GO:0005634;GO:0016791;GO:0051030;GO:0015030;GO:0030532	nucleus;phosphatase activity;snRNA transport;Cajal body;small nuclear ribonucleoprotein complex	70.10	nucleus	16008839	There are two isoforms of TIM50: The nuclear isoform TIM50a participates in the release of snRNPs and SMN from the Cajal body (this complex). The mitochondrial isoform is an essential component of the TIM23 complex and regulates mitochondrial integrity and cell death.	None	The splice variant/isoform TIM50a/TIMM50a is strictly nuclear and enriched in speckles with snRNPs.	Homo sapiens (Human);Homo sapiens (Human)	Coilin;Isoform 2 of Mitochondrial import inner membrane translocase subunit TIM50	COIL;TIMM50	CLN80;TIM50
3102	DHX9-ADAR-vigilin-DNA-PK-Ku antigen complex	Human	None	None	P12956;P13010;P55265;P78527;Q00341;Q08211	2547;7520;103;5591;3069;1660	MI:0007-anti tag coimmunoprecipitation	GO:0006265;GO:0007059;GO:0016556;GO:0003723;GO:0051276;GO:0005634	DNA topological change;chromosome segregation;mRNA modification;RNA binding;chromosome organization;nucleus	10.01.09.05;10.03.04.05;11.06.03;16.03.03;42.10.03;70.10	DNA conformation modification (e.g. chromatin);chromosome segregation/division;mRNA modification;RNA binding;organization of chromosome structure;nucleus	15723802	Vigilin and DDP1 bind specifically to Inosine-containing RNAs.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	X-ray repair cross-complementing protein 6;X-ray repair cross-complementing protein 5;Double-stranded RNA-specific adenosine deaminase;DNA-dependent protein kinase catalytic subunit;Vigilin;ATP-dependent RNA helicase A	XRCC6;XRCC5;ADAR;PRKDC;HDLBP;DHX9	G22P1;G22P2;ADAR1 DSRAD G1P1 IFI4;HYRC HYRC1;HBP VGL;DDX9 LKP NDH2
3103	ITGAV-ITGB3-SLC3A2 complex	Human	integrin complex	None	P05106;P06756;P08195	3690;3685;6520	MI:0019-coimmunoprecipitation	GO:0007155;GO:0005886;GO:0048870	cell adhesion;plasma membrane;cell motility	34.07;70.02	cell adhesion;eukaryotic plasma membrane / membrane attached	18032696	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-3;Integrin alpha-V;4F2 cell-surface antigen heavy chain	ITGB3;ITGAV;SLC3A2	GP3A;MSK8 VNRA VTNR;MDU1
3104	ITGB1-NRP1 complex	Human	None	None	O14786;P05556	8829;3688	MI:0019-coimmunoprecipitation	GO:0007155;GO:0005886	cell adhesion;plasma membrane	34.07;70.02	cell adhesion;eukaryotic plasma membrane / membrane attached	17726369	NP-1 interacts with integrin beta1 to coordinate signaling events that promote cell adherence and invasiveness.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Neuropilin-1;Integrin beta-1	NRP1;ITGB1	NRP, VEGF165R;FNRB, MDF2, MSK12
3110	ITGAV-P2RY2-GNA12 complex	Human	None	None	P06756;P41231;Q03113	3685;5029;2768	MI:0019-coimmunoprecipitation	GO:0016477;GO:0005886	cell migration;plasma membrane	34.05.01;70.02	cell migration;eukaryotic plasma membrane / membrane attached	17452627	Alpha(v) integrin complexes provide the P2Y2R with access to G12, thereby allowing activation of this heterotrimeric G protein that controls actin cytoskeletal rearrangements required for chemotaxis.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin alpha-V;P2Y purinoceptor 2;Guanine nucleotide-binding protein subunit alpha-12	ITGAV;P2RY2;GNA12	MSK8 VNRA VTNR;P2RU1;None
3111	ITGA9-ITGB1-SPP1 complex	Human	integrin complex	None	P05556;P10451;Q13797	3688;6696;3680	MI:0004-affinity chromatography technology	GO:0005515;GO:0007155	protein binding;cell adhesion	16.01;34.07	protein binding;cell adhesion	16005200	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-1;Osteopontin;Integrin alpha-9	ITGB1;SPP1;ITGA9	FNRB, MDF2, MSK12;BNSP OPN;None
3112	ITGA5-ITGB1-SPP1 complex	Human	integrin complex	None	P05556;P08648;P10451	3688;3678;6696	MI:0004-affinity chromatography technology	GO:0005515;GO:0007155	protein binding;cell adhesion	16.01;34.07	protein binding;cell adhesion	16005200	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-1;Integrin alpha-5;Osteopontin	ITGB1;ITGA5;SPP1	FNRB, MDF2, MSK12;FNRA;BNSP OPN
3115	ITGA2B-ITGB3-ICAM4 complex	Human	None	None	P05106;P08514;Q14773	3690;3674;3386	MI:0004-affinity chromatography technology	GO:0007155	cell adhesion	34.07	cell adhesion	12477717	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-3;Integrin alpha-IIb;Intercellular adhesion molecule 4	ITGB3;ITGA2B;ICAM4	GP3A;GP2B ITGAB;LW
3117	ITGB5-ITGAV-VTN complex	Human	integrin complex	None	P04004;P06756;P18084	7448;3685;3693	MI:0019-coimmunoprecipitation	GO:0005515;GO:0007155	protein binding;cell adhesion	16.01;34.07	protein binding;cell adhesion	1694173	In purified form, alpha(v)-beta5 preferentially binds to vitronectin.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Vitronectin;Integrin alpha-V;Integrin beta-5	VTN;ITGAV;ITGB5	None;MSK8 VNRA VTNR;None
3118	SMN complex (GEMIN2, SMN1, SNRPB, SNRPDs)	Human	SMN-GEMIN2-SNRP complex	HeLa cells	O14893;P14678;P62304;P62314;P62316;P62318;Q16637	8487;6628;6635;6632;6633;6634;None	MI:0018-two hybrid;MI:0019-coimmunoprecipitation;MI:0047-far western blotting	GO:0005737;GO:0000387;GO:0034718	cytoplasm;spliceosomal snRNP assembly;SMN-Gemin2 complex	70.03	cytoplasm	9323129	SMN (Survival of Motor Neurons) and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins.The SMN/SIP1 complex is very stable. The findings suggest a role for SMN and SIP1 in spliceosomal snRNP biogenesis and function.	Spinal muscular atrophy (SMA)	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Gem-associated protein 2;Small nuclear ribonucleoprotein-associated proteins B and B';Small nuclear ribonucleoprotein E;Small nuclear ribonucleoprotein Sm D1;Small nuclear ribonucleoprotein Sm D2;Small nuclear ribonucleoprotein Sm D3;Survival motor neuron protein	GEMIN2;SNRPB;SNRPE;SNRPD1;SNRPD2;SNRPD3;SMN1	SIP1;COD SNRPB1;None;None;SNRPD1;None;SMN SMNT
3120	OCT1-OBF1-TLE1 complex	Human	POU2AF1-POU2F1-TLE1	HEK 293A cells	P14859;Q04724;Q16633	5451;7088;5450	MI:0412-electrophoretic mobility supershift assay	GO:0045892;GO:0003677;GO:0005634	negative regulation of DNA-templated transcription;DNA binding;nucleus	11.02.03.04.03;16.03.01;70.10	transcription repression;DNA binding;nucleus	16103132	Transcription activation by Oct1 in conjunction with OBF1 can be prevented by TLE1.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	POU domain, class 2, transcription factor 1;Transducin-like enhancer protein 1;POU domain class 2-associating factor 1	POU2F1;TLE1;POU2AF1	OCT1 OTF1;None;BOB1 OBF1
3121	OCT2-TLE4 complex	Human	POU2F2-TLE4 complex	HEK 293A cells	P09086;Q04727	5452;7091	MI:0096-pull down	GO:0045892;GO:0003677;GO:0005634	negative regulation of DNA-templated transcription;DNA binding;nucleus	11.02.03.04.03;16.03.01;70.10	transcription repression;DNA binding;nucleus	16103132	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	POU domain, class 2, transcription factor 2;Transducin-like enhancer protein 4	POU2F2;TLE4	OCT2 OTF2;GRG4 KIAA1261
3123	TLE2 homodimer complex	Human	None	None	Q04725	7089	MI:0096-pull down	GO:0045892;GO:0005515;GO:0005634	negative regulation of DNA-templated transcription;protein binding;nucleus	11.02.03.04.03;16.01;70.10	transcription repression;protein binding;nucleus	9874198	TLE2 dimer has no DNA-binding ability but can be recuited to specific DNA sites through interaction with DNA-binding proteins.	None	None	Homo sapiens (Human)	Transducin-like enhancer protein 2	TLE2	None
3124	TLE1-TLE2 complex	Human	None	None	Q04724;Q04725	7088;7089	MI:0018-two hybrid;MI:0096-pull down	GO:0045892;GO:0005515;GO:0005634	negative regulation of DNA-templated transcription;protein binding;nucleus	11.02.03.04.03;16.01;70.10	transcription repression;protein binding;nucleus	9874198	TLE1/2 heterodimer has no DNA-binding ability but can be recuited to specific DNA sites through interaction with DNA-binding proteins.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Transducin-like enhancer protein 1;Transducin-like enhancer protein 2	TLE1;TLE2	None;None
3127	TLE-Histone H3 complex	Human	None	Jurkat cells	P68431;Q04724	None;7088	MI:0047-far western blotting	GO:0006265;GO:0045892;GO:0051276;GO:0005634	DNA topological change;negative regulation of DNA-templated transcription;chromosome organization;nucleus	10.01.09.05;11.02.03.04.03;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription repression;organization of chromosome structure;nucleus	9334241	The authors postulate that TLEs regulate gene expression by interacting with nucleosomes through associations with the N-terminus of H3 proteins.	None	Since the authors did not specify histone H3 and TLE, we used HIST1H3A and TLE1.	Homo sapiens (Human);Homo sapiens (Human)	Histone H3.1;Transducin-like enhancer protein 1	H3C1;TLE1	H3FA,HIST1H3A;None
3128	Gamma-secretase complex (APH1B, PSEN1, PSENEN, NCSTN)	Human	None	None	P49768;Q8WW43;Q92542;Q9NZ42	5663;83464;23385;55851	MI:0019-coimmunoprecipitation	GO:0016485;GO:0051090;GO:0023052;GO:0007219;GO:0005886;GO:0005794	protein processing;regulation of DNA-binding transcription factor activity;signaling;Notch signaling pathway;plasma membrane;Golgi apparatus	14.07.11;18.02.09;30.01;30.05.02.14;70.02;70.08	protein processing (proteolytic);regulator of transcription factor;cellular signalling;Notch-receptor signalling pathway;eukaryotic plasma membrane / membrane attached;Golgi	15286082	A multimeric gamma-secretase complex that contains the presenilin-1 or presenilin-2 and the membrane glycoprotein nicastrin processes a number of type I transmembrane proteins such as the beta-amyloid precursor protein and the cell surface receptor notch-1. Three variants of APH1 (APH1A short, APH1A long and APH1B) as well as two presenillin variants (PSEN1 and PSEN2) allow the formation of six different gamma-secretase complexes.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Presenilin-1;Gamma-secretase subunit APH-1B;Nicastrin;Gamma-secretase subunit PEN-2	PSEN1;APH1B;NCSTN;PSENEN	AD3 PS1 PSNL1;PSFL;KIAA0253;PEN2
3129	STAT6-p100-RHA complex	Human	None	None	P42226;Q08211;Q7KZF4	6778;1660;27044	MI:0402-chromatin immunoprecipitation assay	GO:0051276;GO:0006265;GO:0045893;GO:0003677;GO:0005634	chromosome organization;DNA topological change;positive regulation of DNA-templated transcription;DNA binding;nucleus	42.10.03;10.01.09.05;11.02.03.04.01;16.03.01;70.10	organization of chromosome structure;DNA conformation modification (e.g. chromatin);transcription activation;DNA binding;nucleus	16914450	Experiments show that p100 protein mediates the assembly of the ternary complex  STAT6-p100-RHA. Chromatin immunoprecipitation studies show that RHA together with p100 enhance the binding of STAT6 on the human Ig-epsilon promoter after IL-4 stimulation. The authors propose that the ternary protein complex may facilitate the unwinding of the chromatin structure and accessibility of the promoter.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Signal transducer and activator of transcription 6;ATP-dependent RNA helicase A;Staphylococcal nuclease domain-containing protein 1	STAT6;DHX9;SND1	None;DDX9 LKP NDH2;TDRD11
3132	OCT1-OBF1-DNA complex	Human	POU2AF1-POU2F1 complex	B-cells	P14859;Q16633	5451;5450	MI:0412-electrophoretic mobility supershift assay	GO:0003677;GO:0005634;GO:0006355	DNA binding;nucleus;regulation of DNA-templated transcription	16.03.01;70.10;11.02.03.04	DNA binding;nucleus;transcriptional control	12727885	The OCT1 dimer is a better substrate for OBF1 than the monomer. OBF1 stabilizes the OCT1 dimer DNA complex by reducing its dissociation rate. The same complex has been isolated in HEK293 cells. (PMID:16103132)	None	None	Homo sapiens (Human);Homo sapiens (Human)	POU domain, class 2, transcription factor 1;POU domain class 2-associating factor 1	POU2F1;POU2AF1	OCT1 OTF1;BOB1 OBF1
3133	Phosphatidylinositol 3-kinase (PIK3CA, PIK3R1)	Human	None	None	P27986;P42336	5295;5290	MI:0114-x-ray crystallography	GO:0005524;GO:0005886;GO:0046854;GO:0048015	ATP binding;plasma membrane;phosphatidylinositol phosphate biosynthetic process;phosphatidylinositol-mediated signaling	16.19.03;70.02	ATP binding;eukaryotic plasma membrane / membrane attached	18079394	Phosphatidylinositol 3-kinases (PI3Ks) are lipid kinases that phosphorylate phosphatidylinositol 4,5-bisphosphate at the 3-position of the inositol ring, and thus generate phosphatidylinositol 3,4,5-trisphosphate (PIP3 ), which, in turn, initiates a vast array of signaling events. PI3Ks are heterodimers, composed of catalytic and regulatory subunits, that are activated by growth factor-receptor tyrosine kinases.	In different types of cancer PIK3CA was found to be mutated. Defects in the phosphatidylinositol 3-kinase pathway contribute to type II diabetes.	None	Homo sapiens (Human);Homo sapiens (Human)	Phosphatidylinositol 3-kinase regulatory subunit alpha;Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	PIK3R1;PIK3CA	GRB1;None
3135	TLE1 corepressor complex (MASH1 promoter-corepressor complex)	Human	None	brain	P06748;P09874;P19338;P34932;Q02880;Q04724;Q15233;Q92878	4869;142;4691;3308;7155;7088;4841;10111	MI:0071-molecular sieving	GO:0045892;GO:0005515;GO:0003677;GO:0030182;GO:0005634	negative regulation of DNA-templated transcription;protein binding;DNA binding;neuron differentiation;nucleus	11.02.03.04.03;16.01;16.03.01;43.03.13;70.10	transcription repression;protein binding;DNA binding;neuron;nucleus	15607978	The TLE1 complex is required for HES1-mediated transcription repression. PARP1 is inactive in the TLE1 complex. After Ca(2+) induction, kinase CaMKII-delta activates PARP1 leading to dismissal of the TLE1 corepresspor complex from HES1.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Nucleophosmin;Poly [ADP-ribose] polymerase 1;Nucleolin;Heat shock 70 kDa protein 4;DNA topoisomerase 2-beta;Transducin-like enhancer protein 1;Non-POU domain-containing octamer-binding protein;DNA repair protein RAD50	NPM1;PARP1;NCL;HSPA4;TOP2B;TLE1;NONO;RAD50	NPM;ADPRT PPOL;None;APG2;None;None;NRB54;None
3137	MASH1 promoter-coactivator complex	Human	None	brain	P09874;P12931;P24928;P62805;P68431;Q14469;Q15233;Q92793;Q92831	142;6714;5430;None;None;3280;4841;1387;8850	MI:0402-chromatin immunoprecipitation assay	GO:0045893;GO:0003677;GO:0007219;GO:0030182;GO:0005634	positive regulation of DNA-templated transcription;DNA binding;Notch signaling pathway;neuron differentiation;nucleus	11.02.03.04.01;16.03.01;30.05.02.14;43.03.13;70.10	transcription activation;DNA binding;Notch-receptor signalling pathway;neuron;nucleus	15607978	Poly(ADP-ribosyl)ation activity of PARP1 is required for dismissal of the TLE1-corepressor complex.	None	Since the authors did not specify histone H3, we used HIST1H3A.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Poly [ADP-ribose] polymerase 1;Proto-oncogene tyrosine-protein kinase Src;DNA-directed RNA polymerase II subunit RPB1;Histone H4;Histone H3.1;Transcription factor HES-1;Non-POU domain-containing octamer-binding protein;CREB-binding protein;Histone acetyltransferase KAT2B	PARP1;SRC;POLR2A;H4C1;H3C1;HES1;NONO;CREBBP;KAT2B	ADPRT PPOL;SRC1;POLR2;H4/A H4FA HIST1H4A;H3FA,HIST1H3A;BHLHB39 HL HRY;NRB54;CBP;PCAF
3138	POSH-AKT2 complex	Human	None	None	P31751;Q7Z6J0	208;57630	MI:0019-coimmunoprecipitation	GO:0007254	JNK cascade	30.01.05.01.02	JNK cascade	14504284	A POSH mutant unable to bind to Akt2 exhibits increased binding to MLK3. This increased binding of MLK3 to POSH is accompanied by increased activation of the JNK signaling pathway. The results suggest that Akt2 negatively regulates the POSH/JNK signaling complex by phosphorylating MLK3 and promoting the disassembly of the JNK signaling complex.	None	None	Homo sapiens (Human);Homo sapiens (Human)	RAC-beta serine/threonine-protein kinase;E3 ubiquitin-protein ligase SH3RF1	AKT2;SH3RF1	None;KIAA1494 POSH POSH1 RNF142 SH3MD2
3140	CRLR-RAMP2 complex	Human	None	HEK 293T cells	O60895;Q16602	10266;10203	MI:0019-coimmunoprecipitation	GO:0007186;GO:0005886	G protein-coupled receptor signaling pathway;plasma membrane	30.05.02.24;70.02	G-protein coupled receptor signalling pathway;eukaryotic plasma membrane / membrane attached	11387328	The results demonstrate that RAMP2 and RAMP3 and not only RAMP1 can promote the full maturation of CRLR, leading to its terminal glycosylation, and only the fully processed receptors were found to bind AM (adrenomedullin) and CGRP (calcitonin gene-related peptide).	None	None	Homo sapiens (Human);Homo sapiens (Human)	Receptor activity-modifying protein 2;Calcitonin gene-related peptide type 1 receptor	RAMP2;CALCRL	None;CGRPR
3141	CRLR-RAMP3 complex	Human	None	HEK 293T cells	O60896;Q16602	10268;10203	MI:0019-coimmunoprecipitation	GO:0007186;GO:0005886	G protein-coupled receptor signaling pathway;plasma membrane	30.05.02.24;70.02	G-protein coupled receptor signalling pathway;eukaryotic plasma membrane / membrane attached	11387328	The results demonstrate that RAMP2 and RAMP3 and not only RAMP1 can promote the full maturation of CRLR, leading to its terminal glycosylation, and only the fully processed receptors were found to bind AM (adrenomedullin) and CGRP (calcitonin gene-related peptide).	None	None	Homo sapiens (Human);Homo sapiens (Human)	Receptor activity-modifying protein 3;Calcitonin gene-related peptide type 1 receptor	RAMP3;CALCRL	None;CGRPR
3142	CAMK2-delta-MASH1 promoter-coactivator complex	Human	None	brain	P09874;P12931;P24928;Q13557;Q14469;Q15233;Q92793;Q92831	142;6714;5430;817;3280;4841;1387;8850	MI:0402-chromatin immunoprecipitation assay	GO:0045893;GO:0005515;GO:0003677;GO:0007219;GO:0030182;GO:0005634	positive regulation of DNA-templated transcription;protein binding;DNA binding;Notch signaling pathway;neuron differentiation;nucleus	11.02.03.04.01;16.01;16.03.01;30.05.02.14;43.03.13;70.10	transcription activation;protein binding;DNA binding;Notch-receptor signalling pathway;neuron;nucleus	15607978	HES1 is phosphorylated by CAMKII-delta during neural stem cell differentiation. This phosphorylation is linked to recruitment of coactivator complexes on the MASH1 promoter.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Poly [ADP-ribose] polymerase 1;Proto-oncogene tyrosine-protein kinase Src;DNA-directed RNA polymerase II subunit RPB1;Calcium/calmodulin-dependent protein kinase type II subunit delta;Transcription factor HES-1;Non-POU domain-containing octamer-binding protein;CREB-binding protein;Histone acetyltransferase KAT2B	PARP1;SRC;POLR2A;CAMK2D;HES1;NONO;CREBBP;KAT2B	ADPRT PPOL;SRC1;POLR2;CAMKD;BHLHB39 HL HRY;NRB54;CBP;PCAF
3144	GRB2-SOS1 complex	Human	None	COS cells	P62993;Q07889	2885;6654	MI:0096-pull down	GO:0007264;GO:0007169	small GTPase mediated signal transduction;transmembrane receptor protein tyrosine kinase signaling pathway	30.01.05.05.01;30.05.01.12	small GTPase mediated signal transduction;transmembrane receptor protein tyrosine kinase signalling pathways	11777939	The authors describe the formation of either a Sos-1-Grb2 (S/G) or a Sos-1-E3b1-Eps8 (S/E/E8) complex, endowed with Ras- and Rac-specific GEF activities, respectively. Sos-1-Grb2 complex is disrupted upon RTKs (receptor tyrosine kinases) activation, whereas the S/E/E8 complex is not.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Growth factor receptor-bound protein 2;Son of sevenless homolog 1	GRB2;SOS1	ASH;None
3149	NK-3-Groucho-HIPK2-SIN3A-RbpA48-HDAC1 complex	Human	None	None	Q04724;Q09028;Q13547;Q96ST3;Q99801;Q9H2X6	7088;5928;3065;25942;4824;28996	MI:0007-anti tag coimmunoprecipitation;MI:0096-pull down	GO:0006265;GO:0045892;GO:0006476;GO:0051276;GO:0005634	DNA topological change;negative regulation of DNA-templated transcription;protein deacetylation;chromosome organization;nucleus	10.01.09.05;11.02.03.04.03;14.07.04;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription repression;modification by acetylation, deacetylation;organization of chromosome structure;nucleus	10559189	The authors postulate that the Nk-3 homeodomain protein recruits a corepressor complex containing Groucho protein, HIPK2 and a histone deacetylase complex to repress transcription.	None	Since the authors did not specify NKX3 and TLE, we used NKX3-1 and TLE1.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transducin-like enhancer protein 1;Histone-binding protein RBBP4;Histone deacetylase 1;Paired amphipathic helix protein Sin3a;Homeobox protein Nkx-3.1;Homeodomain-interacting protein kinase 2	TLE1;RBBP4;HDAC1;SIN3A;NKX3-1;HIPK2	None;RBAP48;RPD3L1;None;NKX3.1 NKX3A;None
3150	NK-3-Groucho complex	Human	None	None	Q04724;Q99801	7088;4824	MI:0096-pull down	GO:0045892;GO:0005634	negative regulation of DNA-templated transcription;nucleus	11.02.03.04.03;70.10	transcription repression;nucleus	10559189	NK-3 homeodomain protein can associate wih the human Groucho homolog TLE in the absence of DNA. This interaction translocates Groucho proteins from the cytoplasm into the nucleus.	None	Since the authors did not specify NKX3 and TLE, we used NKX3-1 and TLE1.	Homo sapiens (Human);Homo sapiens (Human)	Transducin-like enhancer protein 1;Homeobox protein Nkx-3.1	TLE1;NKX3-1	None;NKX3.1 NKX3A
3151	Sulphiredoxin-peroxiredoxin complex	Human	None	None	Q06830;Q9BYN0	5052;140809	MI:0114-x-ray crystallography	GO:0005524;GO:0007165;GO:0005737	ATP binding;signal transduction;cytoplasm	16.19.03;30;70.03	ATP binding;CELLULAR COMMUNICATION/SIGNAL TRANSDUCTION MECHANISM;cytoplasm	18172504	Typical 2-Cys peroxiredoxins (Prxs) have an important role in regulating hydrogen peroxide-mediated cell signalling. In this process, Prxs can become inactivated through the hyperoxidation of an active site Cys residue to Cys sulphinic acid. The unique repair of this moiety by sulphiredoxin (Srx) restores peroxidase activity and terminates the signal.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Peroxiredoxin-1;Sulfiredoxin-1	PRDX1;SRXN1	PAGA PAGB TDPX2;C20orf139 SRX SRX1
3153	GNAQ-GEFT-RHOA complex	Human	None	None	P50148;P61586;Q86VW2	2776;387;115557	MI:0114-x-ray crystallography	GO:0005525	GTP binding	16.19.05	GTP binding	18096806	It is assumed that the complex is involved in signal transduction.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(q) subunit alpha;Transforming protein RhoA;Rho guanine nucleotide exchange factor 25	GNAQ;RHOA;ARHGEF25	GAQ;ARH12 ARHA RHO12;GEFT
3154	Notch2(N-TM)-Notch2(N-EC)-Delta complex	Human	None	SJ-NB5 cells	O00548;Q04721	28514;4853	MI:0006-anti bait coimmunoprecipitation	GO:0007219;GO:0005886	Notch signaling pathway;plasma membrane	30.05.02.14;70.02	Notch-receptor signalling pathway;eukaryotic plasma membrane / membrane attached	9244302	In the trans-Golgi-network Notch2 is cleaved into the transmembrane Notch2(N-TM) subunit and into the extracellular Notch2(N-EC) subunit. Both subunits form a heterodimeric complex. The ligand Delta binds only to the heterodimeric form of Notch.	None	Since the authors did not specify DLL, we used DLL1.	Homo sapiens (Human);Homo sapiens (Human)	Delta-like protein 1;Neurogenic locus notch homolog protein 2	DLL1;NOTCH2	None;None
3155	TFC4-CTNNB1 complex	Human	None	MCF-7 cells	P35222;Q9NQB0	1499;6934	MI:0019-coimmunoprecipitation	GO:0006351;GO:0016055	DNA-templated transcription;Wnt signaling pathway	11;30.05.02.20	TRANSCRIPTION;Wnt signalling pathway	17072303	As a consequence of engaging the canonical Wnt pathway, a beta-catenin-T-cell factor (TCF) transcriptional complex is generated, which has been postulated to trigger the epithelial-mesenchymal transition (EMT) that characterizes the tissue-invasive phenotype of breast cancer.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Catenin beta-1;Transcription factor 7-like 2	CTNNB1;TCF7L2	CTNNB;TCF4
3156	CBF1-HDAC1-SMRT complex	Human	None	None	Q06330;Q13547;Q9Y618	3516;3065;9612	MI:0007-anti tag coimmunoprecipitation	GO:0006265;GO:0045892;GO:0006476;GO:0051276;GO:0005634	DNA topological change;negative regulation of DNA-templated transcription;protein deacetylation;chromosome organization;nucleus	10.01.09.05;11.02.03.04.03;14.07.04;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription repression;modification by acetylation, deacetylation;organization of chromosome structure;nucleus	9694793	CBF1 interacts with a corepressor complex containing HDAC1 and SMRT. Activation of Notch disrupts the formation of the repressor complex by competing of SMRT and Notch for binding with CBF1.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Recombining binding protein suppressor of hairless;Histone deacetylase 1;Nuclear receptor corepressor 2	RBPJ;HDAC1;NCOR2	IGKJRB IGKJRB1 RBPJK RBPSUH;RPD3L1;CTG26
3157	PRLR heterodimer complex, long/short form (LF/S1a)	Human	None	HEK293 cells	P16471-1;P16471-4	5618;5618	MI:0012-bioluminescence resonance energy transfer;MI:0019-coimmunoprecipitation;MI:0047-far western blotting	GO:0004925;GO:0009986;GO:0010533;GO:0046983;GO:0005148	prolactin receptor activity;cell surface;regulation of activation of Janus kinase activity;protein dimerization activity;prolactin receptor binding	None	None	16556730	The process of receptor dimerization can be either constitutive or ligand dependent. The receptor dimer appears in variant (alternatively spliced) forms: as heterodimer long form (LF, 622 aa) - short form (SF) S1a (376 aa) or S1b (288 aa) and homodimers LF - LF, SF - SF. The LF and both SFs of the hPRLR formed homodimers under nonreducing conditions, independently of PRL, but formed only monomers under reducing conditions. Although SF homodimers and their heterodimers with LF mediate JAK2 activation, the SF heterodimer partner lacks cytoplasmic sequences essential for activation of the JAK2/signal transducer and activator of transcription 5 pathway. This prevents the heterodimeric LF from mediating activation of PRL-induced genes.	None	PRLR (long form, LF, 622 aa) = splice variant/isoform; PRLR (short from 1a, S1a, 376 aa) is a splice variant/isoform of PRLR;	Homo sapiens (Human);Homo sapiens (Human)	Isoform 1 of Prolactin receptor;Isoform 4 of Prolactin receptor	PRLR;PRLR	None;None
3158	RIAM-Rap1-GTP-profilin complex	Human	None	COS cells	P07737;P62834;Q7Z5R6	5216;5906;54518	MI:0007-anti tag coimmunoprecipitation	GO:0007155;GO:0030036	cell adhesion;actin cytoskeleton organization	34.07;42.04.03	cell adhesion;actin cytoskeleton	15469846	The results indicate that RIAM can function as a link between Rap1-GTP and the actin regulator Profilin either by direct RIAM binding to Profilin or by RIAM recruitment of Ena/VASP-Profilin complexes.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Profilin-1;Ras-related protein Rap-1A;Amyloid beta A4 precursor protein-binding family B member 1-interacting protein	PFN1;RAP1A;APBB1IP	None;KREV1;PREL1 RARP1 RIAM
3159	RIAM-profilin complex	Human	None	None	P07737;Q7Z5R6	5216;54518	MI:0018-two hybrid	GO:0007155;GO:0030036	cell adhesion;actin cytoskeleton organization	34.07;42.04.03	cell adhesion;actin cytoskeleton	15469846	RIAM  interacts with Profilin and Ena/VASP proteins, molecules that regulate actin dynamics.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Profilin-1;Amyloid beta A4 precursor protein-binding family B member 1-interacting protein	PFN1;APBB1IP	None;PREL1 RARP1 RIAM
3160	RIAM-VASP complex	Human	None	None	P50552;Q7Z5R6	7408;54518	MI:0096-pull down	GO:0007155;GO:0030036	cell adhesion;actin cytoskeleton organization	34.07;42.04.03	cell adhesion;actin cytoskeleton	15469846	RIAM  interacts with Profilin and Ena/VASP proteins, molecules that regulate actin dynamics.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Vasodilator-stimulated phosphoprotein;Amyloid beta A4 precursor protein-binding family B member 1-interacting protein	VASP;APBB1IP	None;PREL1 RARP1 RIAM
3161	PRLR homodimer complex, long form (LF)	Human	PRL receptor dimer complex	HEK293 cells	P16471-1	5618	MI:0012-bioluminescence resonance energy transfer;MI:0019-coimmunoprecipitation;MI:0047-far western blotting	GO:0004925;GO:0009986;GO:0042803;GO:0010533	prolactin receptor activity;cell surface;protein homodimerization activity;regulation of activation of Janus kinase activity	None	None	16556730	The process of receptor dimerization can be either constitutive or ligand dependent. The receptor dimer appears in variant (alternatively spliced) forms: as heterodimer long form (LF, 622 aa) - short form (SF) S1a (376 aa) or S1b (288 aa) and homodimers LF - LF, SF - SF. The LF and both SFs of the hPRLR formed homodimers under nonreducing conditions, independently of PRL, but formed only monomers under reducing conditions. All of the expressed hPRLR forms are located at the cell surface membrane.	None	PRLR (long form, LF, 622 aa) = splice variant/isoform of PRLR.	Homo sapiens (Human)	Isoform 1 of Prolactin receptor	PRLR	None
3162	TF-FVIIa-FXa-TFPI complex	Human	None	None	P00742;P08709;P10646;P13726	2159;2155;7035;2152	MI:0017-classical fluorescence spectroscopy	GO:0007596	blood coagulation	36.25.16.09	blood coagulation	12787023	The authors describe that the FXa-dependent inhibition of TF-FVIIa activity by TFPI leads to formation of the quaternary complex TF-FVIIa-FXa-TFPI.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Coagulation factor X;Coagulation factor VII;Tissue factor pathway inhibitor;Tissue factor	F10;F7;TFPI;F3	None;None;LACI TFPI1;None
3164	HESX1-TLE1 complex	Human	None	None	Q04724;Q9UBX0	7088;8820	MI:0004-affinity chromatography technology;MI:0007-anti tag coimmunoprecipitation	GO:0045892;GO:0003677;GO:0007219;GO:0005634;GO:0021983	negative regulation of DNA-templated transcription;DNA binding;Notch signaling pathway;nucleus;pituitary gland development	11.02.03.04.03;16.03.01;30.05.02.14;70.10	transcription repression;DNA binding;Notch-receptor signalling pathway;nucleus	11731482	HESX1 recruits the TLE1 corepressor to specific promoters during pituitary organogenesis. This complex completely abolishes transcriptional activation mediated by PROP1.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Transducin-like enhancer protein 1;Homeobox expressed in ES cells 1	TLE1;HESX1	None;HANF
3166	AXIN1-APC-CTNNB1-GSK3B complex	Human	AXIN-APC-betaCatenin-GSK3B complex; beta-Catenin destruction complex	SW480 cells	O15169;P25054;P35222;P49841	8312;324;1499;2932	MI:0019-coimmunoprecipitation	GO:0006468;GO:0016055;GO:0030877	protein phosphorylation;Wnt signaling pathway;beta-catenin destruction complex	14.07.03;30.05.02.20	modification by phosphorylation, dephosphorylation, autophosphorylation;Wnt signalling pathway	10906131	The RGS domains of Axin and conductin interact directly with the region containing the third to seventh 20-aa repeats of APC. The interaction of APC with Axin is important for regulating the stability of beta-catenin. APC promotes a GSK-3b-dependent phosphorylation of beta-catenin by interacting with Axin, thereby down-regulating beta-catenin. APC binds not to GSK-3b but forms a complex with GSK-3b when Axin is present.	Adenomatous polyposis coli gene product (APC) functions as a tumor suppressor and its mutations in familial adenomatous polyposis and colorectal cancers lead to the accumulation of cytoplasmic beta-catenin.	Since the authors did not specify Axin, we used isoform Axin1.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Axin-1;Adenomatous polyposis coli protein;Catenin beta-1;Glycogen synthase kinase-3 beta	AXIN1;APC;CTNNB1;GSK3B	AXIN;DP2.5;CTNNB;None
3167	NCOR-SIN3-HDAC-HESX1 complex	Human	None	None	O75182;Q13547;Q92769;Q96ST3;Q9UBX0;Q9Y618	23309;3065;3066;25942;8820;9612	MI:0007-anti tag coimmunoprecipitation	GO:0006265;GO:0045892;GO:0006476;GO:0003677;GO:0007219;GO:0051276;GO:0005634;GO:0021983	DNA topological change;negative regulation of DNA-templated transcription;protein deacetylation;DNA binding;Notch signaling pathway;chromosome organization;nucleus;pituitary gland development	10.01.09.05;11.02.03.04.03;14.07.04;16.03.01;30.05.02.14;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription repression;modification by acetylation, deacetylation;DNA binding;Notch-receptor signalling pathway;organization of chromosome structure;nucleus	11731482	HESX1 recruits the N-Cor-SIN3-HDAC complex to specific promoters during pituitary organogenesis.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Paired amphipathic helix protein Sin3b;Histone deacetylase 1;Histone deacetylase 2;Paired amphipathic helix protein Sin3a;Homeobox expressed in ES cells 1;Nuclear receptor corepressor 2	SIN3B;HDAC1;HDAC2;SIN3A;HESX1;NCOR2	KIAA0700;RPD3L1;None;None;HANF;CTG26
3168	DAXX-AXIN complex	Human	None	HEK 293T cells	O15169;Q9UER7	8312;1616	MI:0007-anti tag coimmunoprecipitation	GO:0005515;GO:0019209;GO:0051090;GO:0009314;GO:0006915	protein binding;kinase activator activity;regulation of DNA-binding transcription factor activity;response to radiation;apoptotic process	16.01;18.02.01.01.05;18.02.09;32.01.13;40.10.02	protein binding;kinase activator;regulator of transcription factor;electromagnetic waves stress response (e.g. UV, X-ray);apoptosis (type I programmed cell death)	17210684	The Daxx-Axin complex formation is enhanced by UV-irradiation.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Axin-1;Death domain-associated protein 6	AXIN1;DAXX	AXIN;BING2 DAP6
3170	Daxx-Axin-p53 complex	Human	None	HEK 293T cells	O15169;P04637;Q9UER7	8312;7157;1616	MI:0007-anti tag coimmunoprecipitation	GO:2001141;GO:0006355;GO:0009314;GO:0006915;GO:0005634	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;response to radiation;apoptotic process;nucleus	11.02.03.04;32.01.13;40.10.02;70.10	transcriptional control;electromagnetic waves stress response (e.g. UV, X-ray);apoptosis (type I programmed cell death);nucleus	17210684	Axin enhances the interaction between DAXX and p53 in a dose-dependent manner. DAXX does not directly interact with p53, but through a bridge by Axin. DAXX-Axin-p53 complex promotes HIPK2 phosphorylation of p53 at Ser(46).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Axin-1;Cellular tumor antigen p53;Death domain-associated protein 6	AXIN1;TP53;DAXX	AXIN;P53;BING2 DAP6
3172	NUMB-TP53-MDM2 complex	Human	None	None	P04637;P49757;Q00987	7157;8650;4193	MI:0019-coimmunoprecipitation	GO:0005515;GO:0007219;GO:0023052	protein binding;Notch signaling pathway;signaling	16.01;30.05.02.14;30.01	protein binding;Notch-receptor signalling pathway;cellular signalling	18172499	NUMB enters in a tricomplex with p53 and the E3 ubiquitin ligase MDM2, thereby preventing ubiquitination and degradation of p53. This results in increased p53 protein levels and activity, and in regulation of p53-dependent phenotypes.	In breast cancers, loss of NUMB expression causes increased activity of the receptor NOTCH. Thus, in these cancers, a single event-loss of NUMB expression determines activation of an oncogene (NOTCH) and attenuation of the p53 tumour suppressor pathway.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cellular tumor antigen p53;Protein numb homolog;E3 ubiquitin-protein ligase Mdm2	TP53;NUMB;MDM2	P53;C14orf41;None
3173	CIN85 homotetramer complex	Human	None	None	Q96B97	30011	MI:0031-protein cross-linking with a bifunctional reagent	GO:0007267	cell-cell signaling	None	None	11071869	CIN85 interacted with itself via its coiledcoilregion, regardless of EGF stimulation.	None	None	Homo sapiens (Human)	SH3 domain-containing kinase-binding protein 1	SH3KBP1	CIN85
3174	CIN85-BLNK complex	Human	None	None	Q8WV28;Q96B97	29760;30011	MI:0019-coimmunoprecipitation	GO:0050853	B cell receptor signaling pathway	None	None	11071869	The authors suggest a novel mechanism in regulation ofthe B cell signaling events in which CIN85 plays aspecific role by association with BLNK or c-Cbl.	None	None	Homo sapiens (Human);Homo sapiens (Human)	B-cell linker protein;SH3 domain-containing kinase-binding protein 1	BLNK;SH3KBP1	BASH SLP65;CIN85
3175	CIN85-CBL complex	Human	CIN85-c-CBL complex	None	P22681;Q96B97	867;30011	MI:0019-coimmunoprecipitation	GO:0005737;GO:0050853	cytoplasm;B cell receptor signaling pathway	70.03	cytoplasm	11071869	The authors suggest a novel mechanism in regulation of the B cell signaling events in which CIN85 plays a specific role by association with BLNK or c-Cbl.	None	None	Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase CBL;SH3 domain-containing kinase-binding protein 1	CBL;SH3KBP1	CBL2 RNF55;CIN85
3176	USP1-UAF1 complex	Human	None	HeLa cells	O94782;Q8TAF3	7398;57599	MI:0004-affinity chromatography technology;MI:0006-anti bait coimmunoprecipitation	GO:0016579;GO:0006974;GO:0005634	protein deubiquitination;cellular response to DNA damage stimulus;nucleus	14.07.05;32.01.09;70.10	modification by ubiquitination, deubiquitination;DNA damage response;nucleus	18082604	The active USP1-UAF1 complex deubiquitinates FANCD2 both as a dimeric complex and a ternary complex containing autocleaved USP1.	This complex regulates the Fanconi anemia (OMIM:227646) pathway by deubiquitinating FANCD2.	None	Homo sapiens (Human);Homo sapiens (Human)	Ubiquitin carboxyl-terminal hydrolase 1;WD repeat-containing protein 48	USP1;WDR48	None;KIAA1449, UAF1
3177	ARHGEF1-GNA14 complex	Human	GNA14-p115RhoGEF complex	HEK293 cells	O95837;Q92888	9630;9138	MI:0019-coimmunoprecipitation;MI:0096-pull down;MI:0416-fluorescence microscopy	GO:0000902;GO:0016049	cell morphogenesis;cell growth	40.01	cell growth / morphogenesis	15735747	The G-protein alpha subunit a13 regulates cell growth and differentiation.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein subunit alpha-14;Rho guanine nucleotide exchange factor 1	GNA14;ARHGEF1	None;None
3181	LMO4-CREB complex	Human	None	HEK 293T cells	P16220;P61968	1385;8543	MI:0007-anti tag coimmunoprecipitation	GO:0045893;GO:0019722;GO:0022008;GO:0048699	positive regulation of DNA-templated transcription;calcium-mediated signaling;neurogenesis;generation of neurons	11.02.03.04.01;30.01.09.03;41.05.13	transcription activation;Ca2+ mediated signal transduction;neurogenesis	16899735	Most probably homodimerization of LMO4 and interaction with CREB is necessary for full Ca(2+)-dependent transcription activation. This complex plays a key role in patterning thalamocortical connections during development.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cyclic AMP-responsive element-binding protein 1;LIM domain transcription factor LMO4	CREB1;LMO4	None;None
3182	FHL2 homodimer complex	Human	None	in vitro, human heart cDNA library	Q14192	2274	MI:0018-two hybrid	GO:0006355;GO:0005515	regulation of DNA-templated transcription;protein binding	11.02.03.04;16.01	transcriptional control;protein binding	11046156	FHL2 protein forms homodimer complexes.	None	None	Homo sapiens (Human)	Four and a half LIM domains protein 2	FHL2	DRAL SLIM3
3183	PDGFRA-SHP-2 complex, PDGF stimulated	Human	None	None	P16234;Q06124	5156;5781	MI:0019-coimmunoprecipitation	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	30.05.01.12	transmembrane receptor protein tyrosine kinase signalling pathways	8943348	The data demonstrate that SHP-2 does not need to be tyrosine phosphorylated in order to bind to the phosphorylated PDGFRA and are consistent with the idea that SHP-2 binds to the PDGFRA directly.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Platelet-derived growth factor receptor alpha;Tyrosine-protein phosphatase non-receptor type 11	PDGFRA;PTPN11	PDGFR2, RHEPDGFRA;PTP2C SHPTP2
3184	FHL3 homodimer complex	Human	None	in vitro, human heart cDNA library	Q13643	2275	MI:0018-two hybrid	GO:0006355;GO:0005515	regulation of DNA-templated transcription;protein binding	11.02.03.04;16.01	transcriptional control;protein binding	11046156	FHL3 protein forms homodimer complexes.	None	None	Homo sapiens (Human)	Four and a half LIM domains protein 3	FHL3	SLIM2
3186	GRB2-SHP-2 complex, PDGF stimulated	Human	None	None	P62993;Q06124	2885;5781	MI:0019-coimmunoprecipitation	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	30.05.01.12	transmembrane receptor protein tyrosine kinase signalling pathways	8943348	In summary, the data demonstrate that activation of the PDGFRA leads to phosphorylation of SHP-2 at Y580, which appears to trigger the formation of a complex between Grb2 and SHP-2. In addition, SHP-2 binds the activated PDGFRA directly, whereas Grb2 binds indirectly, via SHP-2.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Growth factor receptor-bound protein 2;Tyrosine-protein phosphatase non-receptor type 11	GRB2;PTPN11	ASH;PTP2C SHPTP2
3187	FHL2-FHL3 complex	Human	None	in vitro, human heart cDNA library	Q13643;Q14192	2275;2274	MI:0018-two hybrid	GO:0006355	regulation of DNA-templated transcription	11.02.03.04	transcriptional control	11046156	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Four and a half LIM domains protein 3;Four and a half LIM domains protein 2	FHL3;FHL2	SLIM2;DRAL SLIM3
3189	FHL2-CREB complex	Human	None	COS cells	P16220;Q14192	1385;2274	MI:0007-anti tag coimmunoprecipitation	GO:0045893;GO:0003677	positive regulation of DNA-templated transcription;DNA binding	11.02.03.04.01;16.03.01	transcription activation;DNA binding	11046156	FHL proteins differentially modulate CRE-dependent transcription in mammalian cells.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cyclic AMP-responsive element-binding protein 1;Four and a half LIM domains protein 2	CREB1;FHL2	None;DRAL SLIM3
3190	FHL3-CREB complex	Human	None	COS cell	P16220;Q13643	1385;2275	MI:0007-anti tag coimmunoprecipitation	GO:0045893;GO:0003677	positive regulation of DNA-templated transcription;DNA binding	11.02.03.04.01;16.03.01	transcription activation;DNA binding	11046156	FHL proteins differentially modulate CRE-dependent transcription in mammalian cells.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cyclic AMP-responsive element-binding protein 1;Four and a half LIM domains protein 3	CREB1;FHL3	None;SLIM2
3197	SMAD4-SNO-SKI complex	Human	None	HEK 293T cells	P12755;P12757;Q13485	6497;6498;4089	MI:0004-affinity chromatography technology	GO:2001141;GO:0006355;GO:0003677;GO:0007179;GO:0005634	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;DNA binding;transforming growth factor beta receptor signaling pathway;nucleus	11.02.03.04;16.03.01;30.05.01.18.01;70.10	transcriptional control;DNA binding;TGF-beta-receptor signalling pathway;nucleus	10485843	Ski and Sno associate predominantly with the MH2 domain of SMAD4.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Ski oncogene;Ski-like protein;Mothers against decapentaplegic homolog 4	SKI;SKIL;SMAD4	None;SNO;DPC4 MADH4
3198	SKI-SMAD2 complex	Human	SKI-SMAD2 hexameric complex	HEK 293T cells	P12755;Q15796	6497;4087	MI:0007-anti tag coimmunoprecipitation	GO:0045892;GO:0003677;GO:0007179;GO:0005634;GO:0060395	negative regulation of DNA-templated transcription;DNA binding;transforming growth factor beta receptor signaling pathway;nucleus;SMAD protein signal transduction	11.02.03.04.03;16.03.01;30.05.01.18.01;70.10	transcription repression;DNA binding;TGF-beta-receptor signalling pathway;nucleus	10485843	Smad proteins are the DNA-binding partners of Ski. Ski represses TGF(beta)-induced and SMAD-dependent transcriptional activation (PMID:10485843). IT is suggested that Ski negatively regulates TGF-beta signaling by replacing CBP in R-Smad complexes. (PMID:17283070)	None	None	Homo sapiens (Human);Homo sapiens (Human)	Ski oncogene;Mothers against decapentaplegic homolog 2	SKI;SMAD2	None;MADH2 MADR2
3199	SKI-SMAD3 complex	Human	None	HEK 293T cells	P12755;P84022	6497;4088	MI:0007-anti tag coimmunoprecipitation	GO:0045892;GO:0003677;GO:0007179;GO:0005634;GO:0060395	negative regulation of DNA-templated transcription;DNA binding;transforming growth factor beta receptor signaling pathway;nucleus;SMAD protein signal transduction	11.02.03.04.03;16.03.01;30.05.01.18.01;70.10	transcription repression;DNA binding;TGF-beta-receptor signalling pathway;nucleus	10485843	Smad proteins are the DNA-binding partners of Ski. Ski represses TGF(beta)-induced and SMAD-dependent transcriptional activation.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Ski oncogene;Mothers against decapentaplegic homolog 3	SKI;SMAD3	None;MADH3
3200	SMAD4-SKI complex	Human	None	HEK 293T cells	P12755;Q13485	6497;4089	MI:0004-affinity chromatography technology	GO:0045892;GO:0003677;GO:0007179;GO:0005634	negative regulation of DNA-templated transcription;DNA binding;transforming growth factor beta receptor signaling pathway;nucleus	11.02.03.04.03;16.03.01;30.05.01.18.01;70.10	transcription repression;DNA binding;TGF-beta-receptor signalling pathway;nucleus	10485843	Smad proteins are the DNA-binding partners of Ski. Ski represses TGF(beta)-induced and SMAD-dependent transcriptional activation.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Ski oncogene;Mothers against decapentaplegic homolog 4	SKI;SMAD4	None;DPC4 MADH4
3204	SMAD2-SKI-NCOR complex	Human	None	HEK 293T cells	O75376;P12755;Q15796	9611;6497;4087	MI:0007-anti tag coimmunoprecipitation	GO:0045892;GO:0003677;GO:0007179;GO:0005634	negative regulation of DNA-templated transcription;DNA binding;transforming growth factor beta receptor signaling pathway;nucleus	11.02.03.04.03;16.03.01;30.05.01.18.01;70.10	transcription repression;DNA binding;TGF-beta-receptor signalling pathway;nucleus	10485843	Ski recruits the corepressor N-Cor to the SMAD proteins.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Nuclear receptor corepressor 1;Ski oncogene;Mothers against decapentaplegic homolog 2	NCOR1;SKI;SMAD2	KIAA1047;None;MADH2 MADR2
3205	SMAD3-SKI-NCOR complex	Human	None	HEK 293T cells	O75376;P12755;P84022	9611;6497;4088	MI:0007-anti tag coimmunoprecipitation	GO:0045892;GO:0003677;GO:0007179;GO:0005634	negative regulation of DNA-templated transcription;DNA binding;transforming growth factor beta receptor signaling pathway;nucleus	11.02.03.04.03;16.03.01;30.05.01.18.01;70.10	transcription repression;DNA binding;TGF-beta-receptor signalling pathway;nucleus	10485843	Ski recruits the corepressor N-Cor to the SMAD proteins.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Nuclear receptor corepressor 1;Ski oncogene;Mothers against decapentaplegic homolog 3	NCOR1;SKI;SMAD3	KIAA1047;None;MADH3
3206	SMAD4-SKI-NCOR complex	Human	None	HEK 293T cells	O75376;P12755;Q13485	9611;6497;4089	MI:0007-anti tag coimmunoprecipitation	GO:0045892;GO:0003677;GO:0007179;GO:0005634	negative regulation of DNA-templated transcription;DNA binding;transforming growth factor beta receptor signaling pathway;nucleus	11.02.03.04.03;16.03.01;30.05.01.18.01;70.10	transcription repression;DNA binding;TGF-beta-receptor signalling pathway;nucleus	10485843	Ski recruits the corepressor N-Cor to the SMAD proteins.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Nuclear receptor corepressor 1;Ski oncogene;Mothers against decapentaplegic homolog 4	NCOR1;SKI;SMAD4	KIAA1047;None;DPC4 MADH4
3207	LIN2-LIN7-SAP97-MINT1 complex	Human	None	HEK 293 cells , MDCK cells, epithelium	O14910;O14936;Q02410;Q12959	8825;8573;320;1739	MI:0019-coimmunoprecipitation	GO:0006886;GO:0006605;GO:0015031;GO:0051211;GO:0009798;GO:0030855;GO:0002009	intracellular protein transport;protein targeting;protein transport;anisotropic cell growth;axis specification;epithelial cell differentiation;morphogenesis of an epithelium	14.04;20.01.10;40.01.03;41.05.19;45.03.09	protein targeting, sorting and translocation;protein transport;directional cell growth (morphogenesis);asymmetries and axis determination;epithelium	11865057	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein lin-7 homolog A;Peripheral plasma membrane protein CASK;Amyloid-beta A4 precursor protein-binding family A member 1;Disks large homolog 1	LIN7A;CASK;APBA1;DLG1	MALS1 VELI1;LIN2;MINT1 X11;None
3208	LIN2-LIN7 complex	Human	None	HEK 293 cells, epithelium	O14910;O14936	8825;8573	MI:0096-pull down	GO:0006886;GO:0006605;GO:0015031;GO:0051211;GO:0009798;GO:0030855;GO:0002009	intracellular protein transport;protein targeting;protein transport;anisotropic cell growth;axis specification;epithelial cell differentiation;morphogenesis of an epithelium	14.04;20.01.10;40.01.03;41.05.19;45.03.09	protein targeting, sorting and translocation;protein transport;directional cell growth (morphogenesis);asymmetries and axis determination;epithelium	11865057	It was earlier described that LIN-2/CASK and LIN-7 form a complex and localize to the basolateral surfaces of renal epithelia and MDCK (Madin-Darby canine kidney) cells (PMID:10710551).	None	None	Homo sapiens (Human);Homo sapiens (Human)	Protein lin-7 homolog A;Peripheral plasma membrane protein CASK	LIN7A;CASK	MALS1 VELI1;LIN2
3209	LIN2-SAP97 complex	Human	None	MDCK cells, epithelium	O14936;Q12959	8573;1739	MI:0096-pull down	GO:0006886;GO:0015031;GO:0051211;GO:0009798;GO:0030855	intracellular protein transport;protein transport;anisotropic cell growth;axis specification;epithelial cell differentiation	14.04;20.01.10;40.01.03;41.05.19;45.03.09	protein targeting, sorting and translocation;protein transport;directional cell growth (morphogenesis);asymmetries and axis determination;epithelium	11865057	Association of SAP97 with LIN-2/CASK is crucial for lateral localization of SAP97 in MDCK cells.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Peripheral plasma membrane protein CASK;Disks large homolog 1	CASK;DLG1	LIN2;None
3213	ULBP1-KLRK1-HCST complex	Human	None	None	P26718;Q9BZM6;Q9UBK5	22914;80329;10870	MI:0004-affinity chromatography technology	GO:0006955	immune response	36.25.16	immune response	11239445	The ULBPs and the MICs share the property of binding to the NKG2D/DAP10 receptor and provide a positive signal for NK cell activation and cytotoxicity that can override the negative signal mediated by MHC class I/KIR engagement.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	NKG2-D type II integral membrane protein;UL16-binding protein 1;Hematopoietic cell signal transducer	KLRK1;ULBP1;HCST	D12S2489E NKG2D;N2DL1 RAET1I;DAP10 KAP10 PIK3AP
3229	CDK9-IL6ST complex	Human	None	293 cells	P40189;P50750	3572;1025	MI:0019-coimmunoprecipitation;MI:0047-far western blotting	GO:0005737;GO:0005634;GO:0070691;GO:0005138	cytoplasm;nucleus;P-TEFb complex;interleukin-6 receptor binding	70.03;70.10	cytoplasm;nucleus	12386808	The pleiotropic activities of the gp130-utilizing cytokines point to an extensive role for Cdk9 as a regulator of immune response, inflammation and cell differentiation.	None	Cdk9 is expressed both in the nucleus and in the cytoplasm, and the kinase of the P-TEFb complex, involved in basal transcription.	Homo sapiens (Human);Homo sapiens (Human)	Interleukin-6 receptor subunit beta;Cyclin-dependent kinase 9	IL6ST;CDK9	None;CDC2L4 TAK
3231	EPS15-STON2 complex	Human	Eps15-stonin2 complex	None	P42566;Q8WXE9	2060;85439	MI:0077-nuclear magnetic resonance	GO:0006886;GO:0006605;GO:0015031;GO:0016192	intracellular protein transport;protein targeting;protein transport;vesicle-mediated transport	14.04;20.01.10;20.09.07	protein targeting, sorting and translocation;protein transport;vesicular transport (Golgi network, etc.)	18200045	Eps15 and stonin2 have both been shown to directly associate with the clathrin adaptor complex AP-2 and to localize to clathrin-coated pits (CCPs).	None	None	Homo sapiens (Human);Homo sapiens (Human)	Epidermal growth factor receptor substrate 15;Stonin-2	EPS15;STON2	AF1P;STN2 STNB
3233	SMAD2-SMAD4-FAST1-TGIF complex, TGF(beta) induced	Human	None	COS-1 cells, TGF(beta) stimulated	O75593;Q13485;Q15583;Q15796	8928;4089;7050;4087	MI:0007-anti tag coimmunoprecipitation	GO:0045892;GO:0003677;GO:0007179;GO:0005634;GO:0071559	negative regulation of DNA-templated transcription;DNA binding;transforming growth factor beta receptor signaling pathway;nucleus;response to transforming growth factor beta	11.02.03.04.03;16.03.01;30.05.01.18.01;70.10	transcription repression;DNA binding;TGF-beta-receptor signalling pathway;nucleus	9389648	This complex is only present in TGF(beta)-treated cells.	None	The orthologous human proteins are used.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Forkhead box protein H1;Mothers against decapentaplegic homolog 4;Homeobox protein TGIF1;Mothers against decapentaplegic homolog 2	FOXH1;SMAD4;TGIF1;SMAD2	FAST1 FAST2;DPC4 MADH4;TGIF;MADH2 MADR2
3234	SMAD2-SMAD4-FAST1-TGIF-HDAC1 complex, TGF(beta) induced	Human	None	COS-1 cells, TGF(beta)-stimulated	O75593;Q13485;Q13547;Q15583;Q15796	8928;4089;3065;7050;4087	MI:0007-anti tag coimmunoprecipitation	GO:0006265;GO:0045892;GO:0003677;GO:0007179;GO:0051276;GO:0005634;GO:0071559	DNA topological change;negative regulation of DNA-templated transcription;DNA binding;transforming growth factor beta receptor signaling pathway;chromosome organization;nucleus;response to transforming growth factor beta	10.01.09.05;11.02.03.04.03;16.03.01;30.05.01.18.01;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription repression;DNA binding;TGF-beta-receptor signalling pathway;organization of chromosome structure;nucleus	10199400	This complex is only present in TGF(beta)-treated cells. Interaction of TGIF with HDAC1 is necessary for silencing of TGF(beta) transcriptional responses.	None	The orthologous human proteins are used.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Forkhead box protein H1;Mothers against decapentaplegic homolog 4;Histone deacetylase 1;Homeobox protein TGIF1;Mothers against decapentaplegic homolog 2	FOXH1;SMAD4;HDAC1;TGIF1;SMAD2	FAST1 FAST2;DPC4 MADH4;RPD3L1;TGIF;MADH2 MADR2
3262	SCAMP1-SCAMP2-SCAMP3 complex	Human	None	None	O14828;O15126;O15127	10067;9522;10066	MI:0019-coimmunoprecipitation	GO:0015031;GO:0006892;GO:0016192;GO:0140318	protein transport;post-Golgi vesicle-mediated transport;vesicle-mediated transport;protein transporter activity	20.01.10;20.09.07.06;20.09.07	protein transport;post Golgi transport;vesicular transport (Golgi network, etc.)	9224770	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Secretory carrier-associated membrane protein 3;Secretory carrier-associated membrane protein 1;Secretory carrier-associated membrane protein 2	SCAMP3;SCAMP1;SCAMP2	C1orf3 PROPIN1;SCAMP;None
3263	HERP1/HEY2-NCOR-SIN3A complex	Human	None	None	Q13547;Q96ST3;Q9UBP5;Q9Y618	3065;25942;23493;9612	MI:0007-anti tag coimmunoprecipitation	GO:0006265;GO:0045892;GO:0003677;GO:0051276;GO:0005634	DNA topological change;negative regulation of DNA-templated transcription;DNA binding;chromosome organization;nucleus	10.01.09.05;11.02.03.04.03;16.03.01;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription repression;DNA binding;organization of chromosome structure;nucleus	11486045	HERP1/HEY2 associates with the SIN3A complex.	None	The authors state that SIN3A is part of the SIN3A complex, described in PMID:11784859.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone deacetylase 1;Paired amphipathic helix protein Sin3a;Hairy/enhancer-of-split related with YRPW motif protein 2;Nuclear receptor corepressor 2	HDAC1;SIN3A;HEY2;NCOR2	RPD3L1;None;BHLHB32 CHF1 GRL HERP HERP1 HRT2;CTG26
3269	RB1-HDAC1-BRG1 complex	Human	None	None	P06400;P51532;Q13547	5925;6597;3065	MI:0007-anti tag coimmunoprecipitation	GO:0006265;GO:0045892;GO:0051276;GO:0005634;GO:0051726	DNA topological change;negative regulation of DNA-templated transcription;chromosome organization;nucleus;regulation of cell cycle	10.01.09.05;11.02.03.04.03;42.10.03;70.10;10.03.01	DNA conformation modification (e.g. chromatin);transcription repression;organization of chromosome structure;nucleus;mitotic cell cycle and cell cycle control	10778858	Rb forms a repressor containing histone deacetylase (HDAC) and the hSWI/SNF nucleosome remodeling complex, which inhibits transcription of genes for cyclins E and A and arrests cells in the G1 phase of the cell cycle.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Retinoblastoma-associated protein;Transcription activator BRG1;Histone deacetylase 1	RB1;SMARCA4;HDAC1	None;BAF190A BRG1 SNF2B SNF2L4;RPD3L1
3270	Delta1 homodimer complex	Human	None	HEK 293T cells	O00548	28514	MI:0007-anti tag coimmunoprecipitation	GO:0007219	Notch signaling pathway	30.05.02.14	Notch-receptor signalling pathway	12794186	None	None	None	Homo sapiens (Human)	Delta-like protein 1	DLL1	None
3271	Gamma-secretase-Delta1 complex	Human	None	None	O00548;P49768;Q92542;Q96BI3;Q9NZ42	28514;5663;23385;51107;55851	MI:0071-molecular sieving	GO:0007219	Notch signaling pathway	30.05.02.14	Notch-receptor signalling pathway	12794186	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Delta-like protein 1;Presenilin-1;Nicastrin;Gamma-secretase subunit APH-1A;Gamma-secretase subunit PEN-2	DLL1;PSEN1;NCSTN;APH1A;PSENEN	None;AD3 PS1 PSNL1;KIAA0253;PSF;PEN2
3284	SMN complex (GEMIN2, GEMIN3, GEMIN4, GEMIN5, SMN)	Human	None	HeLa cells; HEK293T cells	O14893;P57678;Q16637;Q8TEQ6;Q9UHI6	8487;50628;None;25929;11218	MI:0019-coimmunoprecipitation;MI:0051-fluorescence technology;MI:0069-mass spectrometry studies of complexes	GO:0008380;GO:0032774;GO:0003723;GO:0006811;GO:0005737;GO:0005634;GO:0065003	RNA splicing;RNA biosynthetic process;RNA binding;ion transport;cytoplasm;nucleus;protein-containing complex assembly	11.04.03.01;11.02;16.03.03;20.01.01;70.03;70.10	splicing;RNA synthesis;RNA binding;ion transport;cytoplasm;nucleus	11714716	The survival of motor neurons (SMN) protein is the product of the disease gene of spinal muscular atrophy and is found both in the cytoplasm and the nucleus, where it is concentrated in gems. SMN is part of a multiprotein complex that includes Gemin2, Gemin3, and Gemin4. The SMN complex plays an important role in the cytoplasmic assembly of small nuclear ribonucleoproteins (snRNPs) and likely other RNPs in pre-mRNA splicing and in the assembly of transcriptosomes. Here, we report the identification of an additional component of the SMN complex, a novel WD repeat protein termed Gemin5. Gemin5 binds SMN directly and is a component of the SMN complex.	Spinal muscular atrophy	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Gem-associated protein 2;Gem-associated protein 4;Survival motor neuron protein;Gem-associated protein 5;Probable ATP-dependent RNA helicase DDX20	GEMIN2;GEMIN4;SMN1;GEMIN5;DDX20	SIP1;None;SMN SMNT;None;DP103 GEMIN3
3296	DDX20-GEMIN4-GEMIN5 complex, SMN-independent intermediate	Human	GEMIN3-GEMIN4-GEMIN5 complex, SMN-independent intermediate	HeLa cells	P57678;Q8TEQ6;Q9UHI6	50628;25929;11218	MI:0019-coimmunoprecipitation;MI:0029-cosedimentation through density gradient;MI:0051-fluorescence technology	GO:0034716;GO:0017069	Gemin3-Gemin4-Gemin5 complex;snRNA binding	None	None	17640873	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Gem-associated protein 4;Gem-associated protein 5;Probable ATP-dependent RNA helicase DDX20	GEMIN4;GEMIN5;DDX20	None;None;DP103 GEMIN3
3297	GEMIN6-GEMIN7-STRAP complex, SMN-independent intermediate	Human	GEMIN6-GEMIN7-UNRIP complex, SMN-independent intermediate	HeLa cells	Q8WXD5;Q9H840;Q9Y3F4	79833;79760;11171	MI:0019-coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0005737;GO:0034717	cytoplasm;Gemin6-Gemin7-unrip complex	70.03	cytoplasm	17640873	Gemin6, Gemin7, and UNRIP form a stable complex outside of the SMN complex in cells with reduced SMN.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Gem-associated protein 6;Gem-associated protein 7;Serine-threonine kinase receptor-associated protein	GEMIN6;GEMIN7;STRAP	None;None;MAWD UNRIP
3298	SMN complex (GEMIN2, GEMIN5, SMN1)	Human	None	HeLa cells	O14893;Q16637;Q8TEQ6	8487;None;25929	MI:0019-coimmunoprecipitation;MI:0029-cosedimentation through density gradient;MI:0416-fluorescence microscopy	GO:0005737;GO:0032797;GO:0034718	cytoplasm;SMN complex;SMN-Gemin2 complex	70.03	cytoplasm	17640873	The survival of motor neurons (SMN) complex is essential for the biogenesis of small nuclear ribonucleoprotein (snRNP) complexes in eukaryotic cells.	Spinal Muscular Atrophy	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Gem-associated protein 2;Survival motor neuron protein;Gem-associated protein 5	GEMIN2;SMN1;GEMIN5	SIP1;SMN SMNT;None
3335	NIAP homotetramer complex	Human	Homotetrameric complex NIAP	HeLa cells	Q13075-1	4671	MI:0019-coimmunoprecipitation;MI:0047-far western blotting	GO:0043067	regulation of programmed cell death	40.10.02.04	regulation of apoptosis	15280366	The expression of NAIP in macrophages and the structural organization of the NAIP raise the possibility that the protein function may be activated by pathogen-associated molecular patterns concomitant with proinflammatory caspases. The authors propose therefore that a key role of NAIP may therefore be to allow caspase-1 activation while suppressing unintentional activation of caspase-3/7 and -9.	None	NAIP exists as a tetramer in both the presence and absence of  ATP. NAIP  (1403 aa) = splice variant/isoform;	Homo sapiens (Human)	Isoform 1 of Baculoviral IAP repeat-containing protein 1	NAIP	BIRC1
3458	B23-NPM3 complex	Human	NPM1-NPM3 complex	HeLa cells	O75607;P06748	10360;4869	MI:0416-fluorescence microscopy	GO:0042254	ribosome biogenesis	12.01	ribosome biogenesis	15596447	NPM3 interacts with Nucleophosmin to inhibit ribosome biogenesis.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Nucleoplasmin-3;Nucleophosmin	NPM3;NPM1	None;NPM
3492	BAX homo-oligomer complex	Human	BAX homo-oligomer complex, after apoptotic stimulation	None	Q07812	581	MI:0030-cross-linking study	GO:0006915;GO:0005739	apoptotic process;mitochondrion	40.10.02;70.16	apoptosis (type I programmed cell death);mitochondrion	15757910	In unstimulated cells BAX normally exists as monomer. After apoptotic stimulation Bax is oligomerized.	None	None	Homo sapiens (Human)	Apoptosis regulator BAX	BAX	BCL2L4
3525	COG subcomplex (COG5, COG6, COG7, COG8)	Human	None	in vitro	P83436;Q96MW5;Q9UP83;Q9Y2V7	91949;84342;10466;57511	MI:0019-coimmunoprecipitation	GO:0016192;GO:0007030;GO:0005737	vesicle-mediated transport;Golgi organization;cytoplasm	20.09.07;42.08;70.03	vesicular transport (Golgi network, etc.);Golgi;cytoplasm	15047703	The COG complex plays important roles in Golgi structure and function.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Conserved oligomeric Golgi complex subunit 7;Conserved oligomeric Golgi complex subunit 8;Conserved oligomeric Golgi complex subunit 5;Conserved oligomeric Golgi complex subunit 6	COG7;COG8;COG5;COG6	None;None;GOLTC1 GTC90;KIAA1134
3530	COG subcomplex (COG5, COG7)	Human	None	in vitro	P83436;Q9UP83	91949;10466	MI:0019-coimmunoprecipitation	GO:0016192;GO:0007030;GO:0005794	vesicle-mediated transport;Golgi organization;Golgi apparatus	20.09.07;42.08;70.08	vesicular transport (Golgi network, etc.);Golgi;Golgi	15047703	The COG complex plays important roles in Golgi structure and function. COG6 interacts with a binary COG5-COG7 subcomplex. Similarly, it was shown that COG8 interacts with a ternary COG5-COG6-COG7subcomplex.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Conserved oligomeric Golgi complex subunit 7;Conserved oligomeric Golgi complex subunit 5	COG7;COG5	None;GOLTC1 GTC90
3532	COG1-COG8 subcomplex	Human	None	in vitro	Q8WTW3;Q96MW5	9382;84342	MI:0007-anti tag coimmunoprecipitation;MI:0018-two hybrid	GO:0015031;GO:0000301;GO:0007030	protein transport;retrograde transport, vesicle recycling within Golgi;Golgi organization	20.01.10;20.09.07.07;42.08	protein transport;retrograde transport;Golgi	16020545	COG1-COG8 subcomplex constitutes a bridge linking COG2-COG3-COG4 subcomplex to COG5-COG6-COG7 subcomplex.For defining the complex composition the authors combined in vitro co-translation assay with co-immunoprecipitation.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Conserved oligomeric Golgi complex subunit 1;Conserved oligomeric Golgi complex subunit 8	COG1;COG8	KIAA1381 LDLB;None
3544	COG2-COG3-COG4 subcomplex	Human	None	in vitro	Q14746;Q96JB2;Q9H9E3	22796;83548;25839	MI:0007-anti tag coimmunoprecipitation	GO:0015031;GO:0000301;GO:0007030	protein transport;retrograde transport, vesicle recycling within Golgi;Golgi organization	20.01.10;20.09.07.07;42.08	protein transport;retrograde transport;Golgi	16020545	For defining the complex composition the authors combined in vitro co-translation assay with co-immunoprecipitation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Conserved oligomeric Golgi complex subunit 2;Conserved oligomeric Golgi complex subunit 3;Conserved oligomeric Golgi complex subunit 4	COG2;COG3;COG4	LDLC;SEC34;None
3545	COG5-COG6-COG7 subcomplex	Human	None	in vitro	P83436;Q9UP83;Q9Y2V7	91949;10466;57511	MI:0007-anti tag coimmunoprecipitation	GO:0015031;GO:0000301;GO:0007030	protein transport;retrograde transport, vesicle recycling within Golgi;Golgi organization	20.01.10;20.09.07.07;42.08	protein transport;retrograde transport;Golgi	16020545	For defining the complex composition the authors combined in vitro co-translation assay with co-immunoprecipitation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Conserved oligomeric Golgi complex subunit 7;Conserved oligomeric Golgi complex subunit 5;Conserved oligomeric Golgi complex subunit 6	COG7;COG5;COG6	None;GOLTC1 GTC90;KIAA1134
3551	COG1-COG8-COG2-COG3-COG4 subcomplex	Human	None	in vitro	Q14746;Q8WTW3;Q96JB2;Q96MW5;Q9H9E3	22796;9382;83548;84342;25839	MI:0007-anti tag coimmunoprecipitation	GO:0015031;GO:0000301;GO:0007030	protein transport;retrograde transport, vesicle recycling within Golgi;Golgi organization	20.01.10;20.09.07.07;42.08	protein transport;retrograde transport;Golgi	16020545	COG1 mediates the interaction between COG1-COG8 and COG2-COG3-COG4.For defining the complex composition the authors combined in vitro co-translation assay with co-immunoprecipitation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Conserved oligomeric Golgi complex subunit 2;Conserved oligomeric Golgi complex subunit 1;Conserved oligomeric Golgi complex subunit 3;Conserved oligomeric Golgi complex subunit 8;Conserved oligomeric Golgi complex subunit 4	COG2;COG1;COG3;COG8;COG4	LDLC;KIAA1381 LDLB;SEC34;None;None
3552	COG1-COG8-COG5-COG6-COG7 subcomplex	Human	None	in vitro	P83436;Q8WTW3;Q96MW5;Q9UP83;Q9Y2V7	91949;9382;84342;10466;57511	MI:0007-anti tag coimmunoprecipitation	GO:0015031;GO:0000301;GO:0007030	protein transport;retrograde transport, vesicle recycling within Golgi;Golgi organization	20.01.10;20.09.07.07;42.08	protein transport;retrograde transport;Golgi	16020545	COG8 mediates interaction between COG1-COG8 subcomplex and COG5-COG6-COG7 subcomplex.For defining the complex composition the authors combined in vitro co-translation assay with co-immunoprecipitation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Conserved oligomeric Golgi complex subunit 7;Conserved oligomeric Golgi complex subunit 1;Conserved oligomeric Golgi complex subunit 8;Conserved oligomeric Golgi complex subunit 5;Conserved oligomeric Golgi complex subunit 6	COG7;COG1;COG8;COG5;COG6	None;KIAA1381 LDLB;None;GOLTC1 GTC90;KIAA1134
3556	COG complex	Human	Conserved oligomeric golgi tethering complex	in vitro	P83436;Q14746;Q8WTW3;Q96JB2;Q96MW5;Q9H9E3;Q9UP83;Q9Y2V7	91949;22796;9382;83548;84342;25839;10466;57511	MI:0007-anti tag coimmunoprecipitation;MI:0071-molecular sieving	GO:0007030;GO:0006486;GO:0006890;GO:0016192;GO:0005737	Golgi organization;protein glycosylation;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;vesicle-mediated transport;cytoplasm	42.08;14.07.02;20.09.07;70.03	Golgi;modification with sugar residues (e.g. glycosylation, deglycosylation);vesicular transport (Golgi network, etc.);cytoplasm	16020545	Two heterotrimeric subassemblies (Cog2/3/4 and Cog5/6/7) are linked by the COG1/8 heterodimer to form the complete COG complex (PMID:16020545). For defining the complex composition the authors combined in vitro co-translation assay with co-immunoprecipitation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Conserved oligomeric Golgi complex subunit 7;Conserved oligomeric Golgi complex subunit 2;Conserved oligomeric Golgi complex subunit 1;Conserved oligomeric Golgi complex subunit 3;Conserved oligomeric Golgi complex subunit 8;Conserved oligomeric Golgi complex subunit 4;Conserved oligomeric Golgi complex subunit 5;Conserved oligomeric Golgi complex subunit 6	COG7;COG2;COG1;COG3;COG8;COG4;COG5;COG6	None;LDLC;KIAA1381 LDLB;SEC34;None;None;GOLTC1 GTC90;KIAA1134
3618	GammaH2AFX-NDHII-Ku70-DNA complex	Human	None	None	P12956;P16104;Q08211	2547;3014;1660	MI:0006-anti bait coimmunoprecipitation	GO:0006281;GO:0006974;GO:0005634	DNA repair;cellular response to DNA damage stimulus;nucleus	10.01.05.01;32.01.09;70.10	DNA repair;DNA damage response;nucleus	15613478	NDH II directly bound to gammaH2AX, whereas association of Ku70 with gammaH2AX was mediated by chromosomal DNA.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	X-ray repair cross-complementing protein 6;Histone H2AX;ATP-dependent RNA helicase A	XRCC6;H2AX;DHX9	G22P1;H2AFX;DDX9 LKP NDH2
3634	NR3C2-UBC9-SRC-1 complex	Human	None	HEK 293 cells	P08235;P63279;Q15788	4306;7329;8648	MI:0019-coimmunoprecipitation;MI:0402-chromatin immunoprecipitation assay	GO:0045893;GO:0005634	positive regulation of DNA-templated transcription;nucleus	11.02.03.04.01;70.10	transcription activation;nucleus	17105732	The results support a physiological role of Ubc9 as a transcriptional MR coactivator, beyond the known SUMO E2-conjugating enzyme.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mineralocorticoid receptor;SUMO-conjugating enzyme UBC9;Nuclear receptor coactivator 1	NR3C2;UBE2I;NCOA1	MCR MLR;UBC9 UBCE9;BHLHE74 SRC1
3677	RIN1-STAM2-HRS complex	Human	None	HeLa cells	O14964;O75886;Q13671	9146;10254;9610	MI:0019-coimmunoprecipitation	GO:0006886;GO:0006605;GO:0015031;GO:0005768	intracellular protein transport;protein targeting;protein transport;endosome	14.04;20.01.10;70.22	protein targeting, sorting and translocation;protein transport;endosome	17403676	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Hepatocyte growth factor-regulated tyrosine kinase substrate;Signal transducing adapter molecule 2;Ras and Rab interactor 1	HGS;STAM2;RIN1	HRS;HBP;None
3678	RIN1-STAM2-EGFR complex, EGF stimulated	Human	None	HEK 293 cells	O75886;P00533;Q13671	10254;1956;9610	MI:0006-anti bait coimmunoprecipitation	GO:0006886;GO:0006605;GO:0015031;GO:0006897;GO:0007173;GO:0005768	intracellular protein transport;protein targeting;protein transport;endocytosis;epidermal growth factor receptor signaling pathway;endosome	14.04;20.01.10;20.09.18.09.01;30.05.01.12.01;70.22	protein targeting, sorting and translocation;protein transport;endocytosis;EGF-receptor signalling pathway;endosome	17403676	It seems that Rin1 plays dual roles, one facilitating cytoskeletal-dependent cellular movement and a second facilitating vesicle trafficking and receptor degradation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Signal transducing adapter molecule 2;Epidermal growth factor receptor;Ras and Rab interactor 1	STAM2;EGFR;RIN1	HBP;ERBB ERBB1 HER1;None
3710	CHL2-BMP2 complex	Human	None	None	P12643;Q6WN34	650;25884	MI:0071-molecular sieving	GO:0007178;GO:0001503;GO:0030316	transmembrane receptor protein serine/threonine kinase signaling pathway;ossification;osteoclast differentiation	30.05.01.18;41.05.17;45.03.05.07	transmembrane receptor protein serine/threonine kinase signalling pathways;osteogenesis;bone	17483092	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Bone morphogenetic protein 2;Chordin-like protein 2	BMP2;CHRDL2	BMP2A;BNF1 CHL2
3711	CHL2-BMP2-TSG complex	Human	None	None	P12643;Q6WN34;Q9GZX9	650;25884;57045	MI:0071-molecular sieving	GO:0007178;GO:0001503;GO:0030316	transmembrane receptor protein serine/threonine kinase signaling pathway;ossification;osteoclast differentiation	30.05.01.18;41.05.17;45.03.05.07	transmembrane receptor protein serine/threonine kinase signalling pathways;osteogenesis;bone	17483092	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Bone morphogenetic protein 2;Chordin-like protein 2;Twisted gastrulation protein homolog 1	BMP2;CHRDL2;TWSG1	BMP2A;BNF1 CHL2;TSG
3739	SKI-SMAD2-SMAD4  pentameric complex	Human	None	None	P12755;Q13485;Q15796	6497;4089;4087	MI:0065-isothermal titration calorimetry;MI:0071-molecular sieving	GO:2001141;GO:0006355;GO:0007179	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;transforming growth factor beta receptor signaling pathway	11.02.03.04;30.05.01.18.01	transcriptional control;TGF-beta-receptor signalling pathway	17283070	The results suggest that Ski negatively regulates TGF-beta signaling by replacing CBP in R-Smad complexes.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Ski oncogene;Mothers against decapentaplegic homolog 4;Mothers against decapentaplegic homolog 2	SKI;SMAD4;SMAD2	None;DPC4 MADH4;MADH2 MADR2
3740	SKI-SMAD3-SMAD4 complex	Human	None	None	P12755;P84022;Q13485	6497;4088;4089	MI:0065-isothermal titration calorimetry;MI:0071-molecular sieving	GO:0006355;GO:0007179;GO:0060395	regulation of DNA-templated transcription;transforming growth factor beta receptor signaling pathway;SMAD protein signal transduction	11.02.03.04;30.05.01.18.01	transcriptional control;TGF-beta-receptor signalling pathway	17283070	The results suggest that Ski negatively regulates TGF-beta signaling by replacing CBP in R-Smad complexes.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Ski oncogene;Mothers against decapentaplegic homolog 3;Mothers against decapentaplegic homolog 4	SKI;SMAD3;SMAD4	None;MADH3;DPC4 MADH4
3749	CREBBP-SMAD2 hexameric complex	Human	None	None	Q15796;Q92793	4087;1387	MI:0065-isothermal titration calorimetry;MI:0071-molecular sieving	GO:2001141;GO:0006355;GO:0007179	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;transforming growth factor beta receptor signaling pathway	11.02.03.04;30.05.01.18.01	transcriptional control;TGF-beta-receptor signalling pathway	17283070	The results suggest that Ski negatively regulates TGF-beta signaling by replacing CBP in R-Smad complexes.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Mothers against decapentaplegic homolog 2;CREB-binding protein	SMAD2;CREBBP	MADH2 MADR2;CBP
3750	CREBBP-SMAD3 hexameric complex	Human	None	None	P84022;Q92793	4088;1387	MI:0065-isothermal titration calorimetry;MI:0071-molecular sieving	GO:2001141;GO:0006355;GO:0007179	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;transforming growth factor beta receptor signaling pathway	11.02.03.04;30.05.01.18.01	transcriptional control;TGF-beta-receptor signalling pathway	17283070	The results suggest that Ski negatively regulates TGF-beta signaling by replacing CBP in R-Smad complexes.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Mothers against decapentaplegic homolog 3;CREB-binding protein	SMAD3;CREBBP	MADH3;CBP
3753	CREBBP-SMAD2-SMAD4 pentameric complex	Human	None	None	Q13485;Q15796;Q92793	4089;4087;1387	MI:0071-molecular sieving	GO:2001141;GO:0006355;GO:0007179	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;transforming growth factor beta receptor signaling pathway	11.02.03.04;30.05.01.18.01	transcriptional control;TGF-beta-receptor signalling pathway	17283070	The results suggest that Ski negatively regulates TGF-beta signaling by replacing CBP in R-Smad complexes.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mothers against decapentaplegic homolog 4;Mothers against decapentaplegic homolog 2;CREB-binding protein	SMAD4;SMAD2;CREBBP	DPC4 MADH4;MADH2 MADR2;CBP
3754	CREBBP-SMAD3-SMAD4 pentameric complex	Human	None	None	P84022;Q13485;Q92793	4088;4089;1387	MI:0071-molecular sieving	GO:2001141;GO:0006355;GO:0007179	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;transforming growth factor beta receptor signaling pathway	11.02.03.04;30.05.01.18.01	transcriptional control;TGF-beta-receptor signalling pathway	17283070	The results suggest that Ski negatively regulates TGF-beta signaling by replacing CBP in R-Smad complexes.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mothers against decapentaplegic homolog 3;Mothers against decapentaplegic homolog 4;CREB-binding protein	SMAD3;SMAD4;CREBBP	MADH3;DPC4 MADH4;CBP
3828	DRIP78-PHLP complex	Human	None	None	Q13371;Q6Y2X3	5082;85406	MI:0007-anti tag coimmunoprecipitation;MI:0012-bioluminescence resonance energy transfer	GO:0006886;GO:0006605;GO:0015031;GO:1902605	intracellular protein transport;protein targeting;protein transport;heterotrimeric G-protein complex assembly	14.04;20.01.10	protein targeting, sorting and translocation;protein transport	17363375	The authors suggest that the DRiP78\u00b7PhLP complex is important in selective formation of different G-beta-gamma pairs.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Phosducin-like protein;DnaJ homolog subfamily C member 14	PDCL;DNAJC14	PHLOP1 PhLP1;DRIP78 HDJ3
3830	ADRB2 homodimer complex	Human	None	None	P07550	154	MI:0012-bioluminescence resonance energy transfer	GO:0007186	G protein-coupled receptor signaling pathway	30.05.02.24	G-protein coupled receptor signalling pathway	17363375	None	None	None	Homo sapiens (Human)	Beta-2 adrenergic receptor	ADRB2	ADRB2R B2AR
3847	TCL1(trimer)-AKT1 complex	Human	None	HEK 293T cells	P31749;P56279	207;8115	MI:0018-two hybrid;MI:0019-coimmunoprecipitation	GO:0019209	kinase activator activity	18.02.01.01.05	kinase activator	10983986	TCL1 forms trimers which associate with AKT1 and binds to AKT PH domain.TCL1 increases Akt kinase activity and as a consequence enhances substrate phosphorylation.It stabilizes the mitochondrial transmembrane potential and enhances cell proliferation and survival.	None	None	Homo sapiens (Human);Homo sapiens (Human)	RAC-alpha serine/threonine-protein kinase;T-cell leukemia/lymphoma protein 1A	AKT1;TCL1A	PKB RAC;TCL1
3848	TCL1(trimer)-AKT2 complex	Human	None	HEK 293T cells	P31751;P56279	208;8115	MI:0018-two hybrid;MI:0019-coimmunoprecipitation	GO:0019209	kinase activator activity	18.02.01.01.05	kinase activator	10983986	TCL1 forms trimers which associate with AKT1 and binds to AKT PH domain.TCL1 increases Akt kinase activity and as a consequence enhances substrate phosphorylation.It stabilizes the mitochondrial transmembrane potential and enhances cell proliferation and survival.	None	None	Homo sapiens (Human);Homo sapiens (Human)	RAC-beta serine/threonine-protein kinase;T-cell leukemia/lymphoma protein 1A	AKT2;TCL1A	None;TCL1
3849	TCL1 homotrimer complex	Human	TCL1A homotrimer complex	HEK 293T cells	P56279	8115	MI:0019-coimmunoprecipitation;MI:0095-proteinchip(r) on a surface-enhanced laser desorption/ionization	GO:0019209	kinase activator activity	18.02.01.01.05	kinase activator	10983986	TCL1 forms trimers which associate with AKT1 and binds to AKT PH domain. TCL1 increases Akt kinase activity and as a consequence enhances substrate phosphorylation. It stabilizes the mitochondrial transmembrane potential and enhances cell proliferation and survival.	None	TCL1 (114 aa) has a predicted molecular weight of 14 kDa and the protein has a unique symmetrical beta-barrel structure.	Homo sapiens (Human)	T-cell leukemia/lymphoma protein 1A	TCL1A	TCL1
3853	Rb-HDAC1 complex	Human	None	C33A cell line	P06400;Q13547	5925;3065	MI:0007-anti tag coimmunoprecipitation	GO:0006265;GO:0000082;GO:0045892;GO:0006476;GO:0051276;GO:0005634	DNA topological change;G1/S transition of mitotic cell cycle;negative regulation of DNA-templated transcription;protein deacetylation;chromosome organization;nucleus	10.01.09.05;10.03.01.01.03;11.02.03.04.03;14.07.04;42.10.03;70.10	DNA conformation modification (e.g. chromatin);G1/S transition of mitotic cell cycle;transcription repression;modification by acetylation, deacetylation;organization of chromosome structure;nucleus	9491888	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Retinoblastoma-associated protein;Histone deacetylase 1	RB1;HDAC1	None;RPD3L1
3900	GABP(gamma)1-E2F1-DP1 complex	Human	None	Saos-2 cells	Q01094;Q14186;Q8TAK5	1869;7027;126626	MI:0412-electrophoretic mobility supershift assay	GO:0000082;GO:0045893;GO:0003677;GO:0006915;GO:0005634	G1/S transition of mitotic cell cycle;positive regulation of DNA-templated transcription;DNA binding;apoptotic process;nucleus	10.03.01.01.03;11.02.03.04.01;16.03.01;40.10.02;70.10	G1/S transition of mitotic cell cycle;transcription activation;DNA binding;apoptosis (type I programmed cell death);nucleus	11884602	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transcription factor E2F1;Transcription factor Dp-1;GA-binding protein subunit beta-2	E2F1;TFDP1;GABPB2	RBBP3;DP1;None
3917	Ternary complex (GATA4, MYOCD, SRF)	Human	None	HeLa cells	P11831;P43694;Q8IZQ8	6722;2626;93649	MI:0412-electrophoretic mobility supershift assay	GO:2001141;GO:0006355;GO:0008134	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;transcription factor binding	11.02.03.04	transcriptional control	15367672	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Serum response factor;Transcription factor GATA-4;Myocardin	SRF;GATA4;MYOCD	None;None;MYCD
3941	RAB11FIP1-RAB11A complex	Human	RCP-RAB11 complex	HeLa cells	P62491;Q6WKZ4	8766;80223	MI:0019-coimmunoprecipitation;MI:0047-far western blotting	GO:0006886;GO:0006605;GO:0015031;GO:0030545	intracellular protein transport;protein targeting;protein transport;signaling receptor regulator activity	14.04;20.01.10;18.02.07	protein targeting, sorting and translocation;protein transport;regulator of receptor activity	15181150	The RCP-Rab11 complex regulates the sorting of transferrin receptors from the degradative to the recycling pathway.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Ras-related protein Rab-11A;Rab11 family-interacting protein 1	RAB11A;RAB11FIP1	RAB11;RCP
3961	SMAD3-cSKI-SIN3A-HDAC1 complex	Human	None	COS-7 cells	P12755;P84022;Q13547;Q96ST3	6497;4088;3065;25942	MI:0007-anti tag coimmunoprecipitation	GO:0006265;GO:0045892;GO:0006476;GO:0003677;GO:0051276;GO:0005634	DNA topological change;negative regulation of DNA-templated transcription;protein deacetylation;DNA binding;chromosome organization;nucleus	10.01.09.05;11.02.03.04.03;14.07.04;16.03.01;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcription repression;modification by acetylation, deacetylation;DNA binding;organization of chromosome structure;nucleus	10575014	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Ski oncogene;Mothers against decapentaplegic homolog 3;Histone deacetylase 1;Paired amphipathic helix protein Sin3a	SKI;SMAD3;HDAC1;SIN3A	None;MADH3;RPD3L1;None
3972	Ubiquitin E3 ligase (SMURF2, SMAD3) - SnoN complex, TGF(beta)-dependent	Human	SMURF2-SMAD3-SnoN complex, TGF(beta)-dependent	HEK 293T cells	P12757;P84022;Q9HAU4	6498;4088;64750	MI:0006-anti bait coimmunoprecipitation	GO:0045892;GO:0016567;GO:0007179;GO:0005634;GO:0006511	negative regulation of DNA-templated transcription;protein ubiquitination;transforming growth factor beta receptor signaling pathway;nucleus;ubiquitin-dependent protein catabolic process	11.02.03.04.03;14.07.05;30.05.01.18.01;70.10;14.13.01.01	transcription repression;modification by ubiquitination, deubiquitination;TGF-beta-receptor signalling pathway;nucleus;proteasomal degradation (ubiquitin/proteasomal pathway)	11389444	This complex allows SMURF2 to target SnoN for ubiquitin-mediated degradation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Ski-like protein;Mothers against decapentaplegic homolog 3;E3 ubiquitin-protein ligase SMURF2	SKIL;SMAD3;SMURF2	SNO;MADH3;None
3979	mTORC2 complex  (MAPKAP1, MLST8, MTOR, RICTOR)	Human	mTORC2 complex  (MLST8, MTOR, RICTOR, SIN1)	HEK 293 cells	P42345;Q6R327;Q9BPZ7;Q9BVC4	2475;253260;79109;64223	MI:0019-coimmunoprecipitation;MI:0071-molecular sieving	GO:0000902;GO:0016049;GO:0030036;GO:0051896	cell morphogenesis;cell growth;actin cytoskeleton organization;regulation of protein kinase B signaling	40.01;42.04.03	cell growth / morphogenesis;actin cytoskeleton	17043309	The authors showed that hSin1, similar to Rictor, is selectively required for the phosphorylation and activation of the TORC2 substrate Akt, but not the TORC1 substrate S6K and that it plays an important role in the regulation of Akt activity and the phosphorylation of Akt substrates in vivo. They mentioned LST8 as a conserved component of the complex but did not show it in the experiments.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein kinase mTOR;Rapamycin-insensitive companion of mTOR;Target of rapamycin complex 2 subunit MAPKAP1;Target of rapamycin complex subunit LST8	MTOR;RICTOR;MAPKAP1;MLST8	FRAP FRAP1 FRAP2 RAFT1 RAPT1;KIAA1999;MIP1, SIN1;GBL, LST8
3988	ClpP complex, heptameric	Human	None	None	Q16740	8192	MI:0071-molecular sieving	GO:0005515;GO:0005739	protein binding;mitochondrion	16.01;70.16	protein binding;mitochondrion	16115876	ClpP occurs as a stable heptamer in solution. Heptameric hClpP has no proteolytic activity and very low peptidase activity.	None	None	Homo sapiens (Human)	ATP-dependent Clp protease proteolytic subunit, mitochondrial	CLPP	None
3991	ClpX complex, hexameric	Human	None	None	O76031	10845	MI:0028-cosedimentation in solution	GO:0005515;GO:0005739	protein binding;mitochondrion	16.01;70.16	protein binding;mitochondrion	16115876	None	None	None	Homo sapiens (Human)	ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial	CLPX	None
3992	ClpXP complex	Human	None	None	O76031;Q16740	10845;8192	MI:0040-electron microscopy	GO:0030163;GO:0005515;GO:0005739	protein catabolic process;protein binding;mitochondrion	14.13;16.01;70.16	protein/peptide degradation;protein binding;mitochondrion	16115876	In the presence of ATP, ClpX promotes interaction between two ClpP rings, forming a proteolytic active ClpXP complex: two rings of ClpP heptamers bind to two ClpX hexamers.	None	None	Homo sapiens (Human);Homo sapiens (Human)	ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial;ATP-dependent Clp protease proteolytic subunit, mitochondrial	CLPX;CLPP	None;None
4025	ACTN1-PARVB complex	Human	Affixin-actinin(alpha) complex	skeletal muscle, fibroblasts	P12814;Q9HBI1	87;29780	MI:0018-two hybrid;MI:0019-coimmunoprecipitation;MI:0047-far western blotting	GO:0007229;GO:0015629	integrin-mediated signaling pathway;actin cytoskeleton	30.05.02.26;70.04.03	integrin receptor signalling pathway;actin cytoskeleton	15159419	Affixin interacts with alpha-actinin and mediates integrin signaling for reorganization of F-actin induced by initial cell\u2013substrate interaction.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Alpha-actinin-1;Beta-parvin	ACTN1;PARVB	None;None
4039	PAR4-BACE1 complex	Human	None	None	P56817;Q96IZ0	23621;5074	MI:0006-anti bait coimmunoprecipitation	GO:0030163	protein catabolic process	14.13	protein/peptide degradation	15671026	The C-terminal domain of PAR-4 is necessary for forming a complex with the cytosolic tail of BACE1. PAR-4 may be directly involved in regulating the APP cleavage activity of BACE1.	This complex is involved in the pathogenesis of Alzheimer disease.	None	Homo sapiens (Human);Homo sapiens (Human)	Beta-secretase 1;PRKC apoptosis WT1 regulator protein	BACE1;PAWR	BACE KIAA1149;PAR4
4043	NEMO-HIF2(alpha)-ARNT complex	Human	None	None	P27540;Q99814;Q9Y6K9	405;2034;8517	MI:0007-anti tag coimmunoprecipitation	GO:2001141;GO:0006355;GO:0007249	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;I-kappaB kinase/NF-kappaB signaling	11.02.03.04;30.01.05.01.04	transcriptional control;NIK-I-kappaB/NF-kappaB cascade	15653678	During hypoxia HIF(alpha) proteins migrate into the nucleus and heterodimerize with the aryl hydrocarbon nuclear translocator ARNT (also called HIF-1(beta)).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Aryl hydrocarbon receptor nuclear translocator;Endothelial PAS domain-containing protein 1;NF-kappa-B essential modulator	ARNT;EPAS1;IKBKG	BHLHE2;BHLHE73 HIF2A MOP2 PASD2;FIP3, NEMO
4062	VEGF-A165-KDR-NRP1 complex	Human	NRP1-VEGFR2-VEGF-A165 complex	endothelial cells	O14786;P15692-4;P35968	8829;7422;3791	MI:0019-coimmunoprecipitation;MI:0107-surface plasmon resonance	GO:0007155;GO:0001525;GO:0007167;GO:0001568;GO:0001944	cell adhesion;angiogenesis;enzyme-linked receptor protein signaling pathway;blood vessel development;vasculature development	34.07;41.05.16;30.05.01;47.03.03.02	cell adhesion;angiogenesis;receptor enzyme mediated signalling;vessels	17575273	VEGF165 mediates the formation of complexes containing VEGFR2 and NRP1, which enhances the affinity of VEGF165 for VEGFR2 and therefore VEGFR2 signaling. VEGF121 does not promote VEGFR2-NRP1 complex formation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Neuropilin-1;Isoform VEGF165 of Vascular endothelial growth factor A;Vascular endothelial growth factor receptor 2	NRP1;VEGFA;KDR	NRP, VEGF165R;VEGF;FLK1 VEGFR2
4072	Ubiquitin E3 ligase (CUL1, RBX1, SKP1)	Human	None	transfected Sf9 cells	P62877;P63208;Q13616	9978;6500;8454	MI:0047-far western blotting	GO:0051276;GO:0016567;GO:0043161;GO:0006511	chromosome organization;protein ubiquitination;proteasome-mediated ubiquitin-dependent protein catabolic process;ubiquitin-dependent protein catabolic process	42.10.03;14.07.05;14.13.01.01	organization of chromosome structure;modification by ubiquitination, deubiquitination;proteasomal degradation (ubiquitin/proteasomal pathway)	15118074	SCFhFBH1 (=SKP1/CUL1/ROC1 - human F-box DNA helicase) can act as helicase and E3 ubiquitin ligase.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase RBX1;S-phase kinase-associated protein 1;Cullin-1	RBX1;SKP1;CUL1	RNF75 ROC1;EMC19 OCP2 SKP1A TCEB1L;None
4082	WRN-XRCC6-XRCC5 complex	Human	KU70-KU86-Werner complex	HeLa nuclear extract	P12956;P13010;Q14191	2547;7520;7486	MI:0019-coimmunoprecipitation;MI:0047-far western blotting	GO:0006281;GO:0003677;GO:0006974;GO:0005634	DNA repair;DNA binding;cellular response to DNA damage stimulus;nucleus	10.01.05.01;16.03.01;32.01.09;70.10	DNA repair;DNA binding;DNA damage response;nucleus	10783163	Ku complex interacts with and stimulates the Werner protein.	Werner syndrome (=is the hallmark premature aging disorder in which affected humans appear older than their chronological age).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	X-ray repair cross-complementing protein 6;X-ray repair cross-complementing protein 5;Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	XRCC6;XRCC5;WRN	G22P1;G22P2;RECQ3 RECQL2
4089	SMAD6-HOXC8 complex	Human	None	None	O43541;P31273	4091;3224	MI:0018-two hybrid;MI:0019-coimmunoprecipitation;MI:0413-electrophoretic mobility shift assay	GO:0045892;GO:0003677	negative regulation of DNA-templated transcription;DNA binding	11.02.03.04.03;16.03.01	transcription repression;DNA binding	10722652	The Smad6-Hoxc8 complex inhibits interaction of Smad1 with Hoxc-8- and Smad1-induced transcription activity.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Mothers against decapentaplegic homolog 6;Homeobox protein Hox-C8	SMAD6;HOXC8	MADH6;HOX3A
4090	SMAD6-HOXA9 complex	Human	None	None	O43541;P31269	4091;3205	MI:0413-electrophoretic mobility shift assay	GO:0003677	DNA binding	16.03.01	DNA binding	10722652	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Mothers against decapentaplegic homolog 6;Homeobox protein Hox-A9	SMAD6;HOXA9	MADH6;HOX1G
4095	CTNNAL1-CTNNB1 complex	Human	Catulin (alpha) - catenin (beta) complex	HEK293T cells; Caco2A cells; A427 cells	P35222;Q9UBT7	1499;8727	MI:0019-coimmunoprecipitation	GO:0023052;GO:0008013;GO:0098609	signaling;beta-catenin binding;cell-cell adhesion	30.01	cellular signalling	14993280	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Catenin beta-1;Alpha-catulin	CTNNB1;CTNNAL1	CTNNB;None
4096	CTNNA1-CTNNB1 complex	Human	Catenin (alpha) - catenin (beta) complex	HEK293T cells; Caco2A cells; A427 cells	P35221;P35222	1495;1499	MI:0019-coimmunoprecipitation	GO:0023052;GO:0008013;GO:0098609	signaling;beta-catenin binding;cell-cell adhesion	30.01	cellular signalling	14993280	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Catenin alpha-1;Catenin beta-1	CTNNA1;CTNNB1	None;CTNNB
4151	TSC (TSC1, TSC2, AXIN, GSK3) complex	Human	None	HEK293T cells	O15169;P49815;P49841;Q92574	8312;7249;2932;7248	MI:0019-coimmunoprecipitation	GO:0033596;GO:0030111;GO:0009299;GO:1904713	TSC1-TSC2 complex;regulation of Wnt signaling pathway;mRNA transcription;beta-catenin destruction complex binding	11.02.03	mRNA synthesis	15972957	TSC1/TSC2 complex associated with GSK3 and Axin promotes beta-catenin degradation to inhibit Wnt-stimulated TCF/LEF-dependent transcription. Beta-catenin signaling plays a role in TSC pathogenesis in vivo and suggest a novel role of GSK3 in modulating the TSC1/TSC2 complex through TSC1 phosphorylation.	angiomyolipomas (AML), lymphangioleiomyomatosis (LAM)	Since the authors did not specify GSK3, we used isoform GSK3B.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Axin-1;Tuberin;Glycogen synthase kinase-3 beta;Hamartin	AXIN1;TSC2;GSK3B;TSC1	AXIN;TSC4;None;KIAA0243, TSC
4158	HSP90-FKBP38-CAM-Ca(2+) complex	Human	None	None	P07900;P0DP23;Q14318	3320;801;23770	MI:0017-classical fluorescence spectroscopy;MI:0019-coimmunoprecipitation	GO:0043067	regulation of programmed cell death	40.10.02.04	regulation of apoptosis	17379601	The authors show that the TPR domain of FKBP38 interacts with the C-terminal domain of Hsp90, but only if the FKBP38-CaM-Ca(2+) complex is preformed. The resulting ternary complex is enzymatically inactive, and the association of Bcl-2 and the PPIase site of FKBP38 is prevented.	None	Since the authors did not specify HSP90, we used isoform HSP90A.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Heat shock protein HSP 90-alpha;Calmodulin-1;Peptidyl-prolyl cis-trans isomerase FKBP8	HSP90AA1;CALM1;FKBP8	HSP90A HSPC1 HSPCA;CALM CAM CAM1;FKBP38
4200	DNM1L-FIS1 complex	Human	DLP1-hFIS1 complex	HeLa cells; COS-7 cells	O00429;Q9Y3D6	10059;51024	MI:0019-coimmunoprecipitation;MI:0055-fluorescent resonance energy transfer	GO:0007005;GO:0000266	mitochondrion organization;mitochondrial fission	42.16	mitochondrion	12861026	The mitochondrial protein hFis1 regulates mitochondrial fission in mammalian cells through an interaction with the dynamin-like protein DLP1.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Dynamin-1-like protein;Mitochondrial fission 1 protein	DNM1L;FIS1	DLP1 DRP1;TTC11
4216	HNRNPU-NR3C1 complex	Human	GR-hnRNP U complex	HeLa S3 cells	P04150;Q00839	2908;3192	MI:0004-affinity chromatography technology;MI:0019-coimmunoprecipitation	GO:2001141;GO:0006355	regulation of RNA biosynthetic process;regulation of DNA-templated transcription	11.02.03.04	transcriptional control	9353307	The glucocorticoid receptor (GR) is a ligand-dependent transcription factor that is able to modulate gene activity by binding to its response element, interactingwith other transcription factors (here = GRIP120 = hnRNP U), and contacting several accessory proteins such as coactivators.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Glucocorticoid receptor;Heterogeneous nuclear ribonucleoprotein U	NR3C1;HNRNPU	GRL;C1orf199 HNRPU SAFA U21.1
4389	EIF3 core complex (EIF3A, EIF3B, EIF3G, EIF3I)	Human	None	None	O75821;P55884;Q13347;Q14152	8666;8662;8668;8661	MI:0096-pull down	GO:0006413	translational initiation	12.04.01	translation initiation	14688252	EIF3b appears to be a central scaffolding subunit.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Eukaryotic translation initiation factor 3 subunit G;Eukaryotic translation initiation factor 3 subunit B;Eukaryotic translation initiation factor 3 subunit I;Eukaryotic translation initiation factor 3 subunit A	EIF3G;EIF3B;EIF3I;EIF3A	EIF3S4;EIF3S9;EIF3S2 TRIP1;EIF3S10 KIAA0139
4392	EIF3 complex (EIF3A, EIF3B, EIF3G, EIF3I, EIF3C)	Human	None	None	O75821;P55884;Q13347;Q14152;Q99613	8666;8662;8668;8661;8663	MI:0096-pull down	GO:0006413	translational initiation	12.04.01	translation initiation	14688252	EIF3b appears to be a central scaffolding subunit. EIF3c is able to associate with the four-subunit eIF3 subcomplex, but does so only weakly under these expression and purification conditions.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Eukaryotic translation initiation factor 3 subunit G;Eukaryotic translation initiation factor 3 subunit B;Eukaryotic translation initiation factor 3 subunit I;Eukaryotic translation initiation factor 3 subunit A;Eukaryotic translation initiation factor 3 subunit C	EIF3G;EIF3B;EIF3I;EIF3A;EIF3C	EIF3S4;EIF3S9;EIF3S2 TRIP1;EIF3S10 KIAA0139;EIF3S8
4395	EIF3 complex (EIF3B, EIF3G, EIF3I)	Human	None	None	O75821;P55884;Q13347	8666;8662;8668	MI:0096-pull down	GO:0006413	translational initiation	12.04.01	translation initiation	14688252	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Eukaryotic translation initiation factor 3 subunit G;Eukaryotic translation initiation factor 3 subunit B;Eukaryotic translation initiation factor 3 subunit I	EIF3G;EIF3B;EIF3I	EIF3S4;EIF3S9;EIF3S2 TRIP1
4399	EIF3 complex (EIF3B, EIF3J, EIF3I)	Human	None	None	O75822;P55884;Q13347	8669;8662;8668	MI:0096-pull down	GO:0006413	translational initiation	12.04.01	translation initiation	14688252	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Eukaryotic translation initiation factor 3 subunit J;Eukaryotic translation initiation factor 3 subunit B;Eukaryotic translation initiation factor 3 subunit I	EIF3J;EIF3B;EIF3I	EIF3S1;EIF3S9;EIF3S2 TRIP1
4403	EIF3 complex (EIF3A, EIF3B, EIF3G, EIF3I, EIF3J)	Human	None	None	O75821;O75822;P55884;Q13347;Q14152	8666;8669;8662;8668;8661	MI:0096-pull down	GO:0006413	translational initiation	12.04.01	translation initiation	14688252	EIF3b appears to be a central scaffolding subunit. The authors conclude that EIF3J promotes the stable association of EIF3 subcomplexes to the 40S ribosomal subunit.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Eukaryotic translation initiation factor 3 subunit G;Eukaryotic translation initiation factor 3 subunit J;Eukaryotic translation initiation factor 3 subunit B;Eukaryotic translation initiation factor 3 subunit I;Eukaryotic translation initiation factor 3 subunit A	EIF3G;EIF3J;EIF3B;EIF3I;EIF3A	EIF3S4;EIF3S1;EIF3S9;EIF3S2 TRIP1;EIF3S10 KIAA0139
4478	CBF-DNA complex	Human	None	HeLa cells	P23511;P25208;Q13952	4800;4801;4802	MI:0096-pull down;MI:0413-electrophoretic mobility shift assay	GO:2001141;GO:0006355;GO:0003677;GO:0005634	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;DNA binding;nucleus	11.02.03.04;16.03.01;70.10	transcriptional control;DNA binding;nucleus	15243141	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Nuclear transcription factor Y subunit alpha;Nuclear transcription factor Y subunit beta;Nuclear transcription factor Y subunit gamma	NFYA;NFYB;NFYC	None;HAP3;None
4498	p32-CBF-DNA complex	Human	None	HeLa cells	P23511;P25208;Q07021;Q13952	4800;4801;708;4802	MI:0096-pull down	GO:0045892;GO:0003677;GO:0005634	negative regulation of DNA-templated transcription;DNA binding;nucleus	11.02.03.04.03;16.03.01;70.10	transcription repression;DNA binding;nucleus	15243141	p32 interacts specifically with CBF-B subunit and also associates with CBF-DNA complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Nuclear transcription factor Y subunit alpha;Nuclear transcription factor Y subunit beta;Complement component 1 Q subcomponent-binding protein, mitochondrial;Nuclear transcription factor Y subunit gamma	NFYA;NFYB;C1QBP;NFYC	None;HAP3;GC1QBP HABP1 SF2P32;None
4869	beta(1)-AR receptosome (ADRB1-SAP97-AKAP79-PRKAR2A)	Human	None	HEK 293 cells	P08588;P13861;P24588;Q12959	153;5576;9495;1739	MI:0019-coimmunoprecipitation;MI:0055-fluorescent resonance energy transfer	GO:0006605;GO:0006468;GO:0007186;GO:0001881	protein targeting;protein phosphorylation;G protein-coupled receptor signaling pathway;receptor recycling	14.04;14.07.03;30.05.02.24	protein targeting, sorting and translocation;modification by phosphorylation, dephosphorylation, autophosphorylation;G-protein coupled receptor signalling pathway	17170109	SAP97 siRNA abolished the ability of the beta(1)-AR to co-immunoprecipitate AKAP79 and SAP97. This indicates that SAP97 probably serves as a bridging molecule between the beta1-AR and the AKAP79-PKA complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Beta-1 adrenergic receptor;cAMP-dependent protein kinase type II-alpha regulatory subunit;A-kinase anchor protein 5;Disks large homolog 1	ADRB1;PRKAR2A;AKAP5;DLG1	ADRB1R, B1AR;PKR2, PRKAR2;AKAP79;None
4976	SVIP-VCP-DERL1 complex	Human	SVIP-p97/VCP-DERL1 complex	HEK 293 cells	P55072;Q8NHG7;Q9BUN8	7415;258010;79139	MI:0007-anti tag coimmunoprecipitation	GO:0030968;GO:0005783	endoplasmic reticulum unfolded protein response;endoplasmic reticulum	32.01.07;70.07	unfolded protein response (e.g. ER quality control);endoplasmic reticulum	17872946	The authors identified SVIP as the first endogenous inhibitor of ERAD (ER-associated degradation) that uses a novel mechanism through inhibiting the assembly of the gp78-p97/VCP-Derlin1 complex. The data suggest that p97/VCP and Derlin1 can form a complex with either gp78 or SVIP. The gp78 complex facilitates ERAD, whereas the SVIP complex inhibits ERAD.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transitional endoplasmic reticulum ATPase;Small VCP/p97-interacting protein;Derlin-1	VCP;SVIP;DERL1	None;None;DER1
4977	AMFR-DERL1-VCP complex	Human	gp78-p97/VCP-DERL1 complex	HEK 293 cells	P55072;Q9BUN8;Q9UKV5	7415;79139;267	MI:0007-anti tag coimmunoprecipitation	GO:0043161;GO:0006511;GO:0030968;GO:0005783	proteasome-mediated ubiquitin-dependent protein catabolic process;ubiquitin-dependent protein catabolic process;endoplasmic reticulum unfolded protein response;endoplasmic reticulum	14.13.01.01;32.01.07;70.07	proteasomal degradation (ubiquitin/proteasomal pathway);unfolded protein response (e.g. ER quality control);endoplasmic reticulum	17872946	The authors identified SVIP as the first endogenous inhibitor of ERAD (ER-associated degradation) that uses a novel mechanism through inhibiting the assembly of the gp78-p97/VCP-Derlin1 complex. The data suggest that p97/VCP and Derlin1 can form a complex with either gp78 or SVIP. The gp78 complex facilitates ERAD, whereas the SVIP complex inhibits ERAD.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transitional endoplasmic reticulum ATPase;Derlin-1;E3 ubiquitin-protein ligase AMFR	VCP;DERL1;AMFR	None;DER1;RNF45
4997	DERL1-VCP-VIMP complex	Human	None	293T cells	P55072;Q9BQE4;Q9BUN8	7415;55829;79139	MI:0019-coimmunoprecipitation	GO:0036503;GO:0030970	ERAD pathway;retrograde protein transport, ER to cytosol	None	None	16186509	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transitional endoplasmic reticulum ATPase;Selenoprotein S;Derlin-1	VCP;SELENOS;DERL1	None;SELS VIMP;DER1
4998	VCP-VIMP-DERL2 complex	Human	p97/VCP-VIMP-DERL2 complex	None	P55072;Q9BQE4;Q9GZP9	7415;55829;51009	MI:0019-coimmunoprecipitation	GO:0030968;GO:0005783;GO:0036503	endoplasmic reticulum unfolded protein response;endoplasmic reticulum;ERAD pathway	32.01.07;70.07	unfolded protein response (e.g. ER quality control);endoplasmic reticulum	16186509	SelK has higher affinity for Derlin-1, whereas SelS has higher affinity for Derlin-2. This suggests that the selenoproteins SelK and SelS could determine the nature of the substrate translocated through the Derlin channel. (PMID:22016385)	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transitional endoplasmic reticulum ATPase;Selenoprotein S;Derlin-2	VCP;SELENOS;DERL2	None;SELS VIMP;DER2; FLANA
4999	VCP-VIMP-DERL1-DERL2-HRD1-SEL1L complex	Human	p97/VCP-VIMP-DERL1-DERL2-HRD1-SEL1L complex	None	P55072;Q86TM6;Q9BQE4;Q9BUN8;Q9GZP9;Q9UBV2	7415;84447;55829;79139;51009;6400	MI:0019-coimmunoprecipitation	GO:0030968;GO:0005783;GO:0036503	endoplasmic reticulum unfolded protein response;endoplasmic reticulum;ERAD pathway	32.01.07;70.07	unfolded protein response (e.g. ER quality control);endoplasmic reticulum	16186509	Cell lin: U373.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transitional endoplasmic reticulum ATPase;E3 ubiquitin-protein ligase synoviolin;Selenoprotein S;Derlin-1;Derlin-2;Protein sel-1 homolog 1	VCP;SYVN1;SELENOS;DERL1;DERL2;SEL1L	None;HRD1 KIAA1810;SELS VIMP;DER1;DER2; FLANA;TSA305
5099	RB1(hypophosphorylated)-E2F4 complex	Human	None	None	P06400;Q16254	5925;1874	MI:0006-anti bait coimmunoprecipitation	GO:0000082;GO:0045892	G1/S transition of mitotic cell cycle;negative regulation of DNA-templated transcription	10.03.01.01.03;11.02.03.04.03	G1/S transition of mitotic cell cycle;transcription repression	9380698	Hypo-phosphorylated Rb interacts with E2F4 in the early G1 phase of the cell cyclus. Inactivation of Rb by hyper-phosphorylation in late G1 phase causes release of E2F, allowing transcription of genes important for DNA synthesis.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Retinoblastoma-associated protein;Transcription factor E2F4	RB1;E2F4	None;None
5100	CyclinD3-CDK4-CDK6 complex	Human	None	None	P11802;P30281;Q00534	1019;896;1021	MI:0007-anti tag coimmunoprecipitation	GO:0000278;GO:0000082;GO:0035556;GO:0007519	mitotic cell cycle;G1/S transition of mitotic cell cycle;intracellular signal transduction;skeletal muscle tissue development	10.03.01.01;10.03.01.01.03;30.01;41.05.15	mitotic cell cycle;G1/S transition of mitotic cell cycle;cellular signalling;myogenesis	8930396	Upon myocyte differentiation subunit composition of the CDK4/6 complex is altered. Interaction with cyclinD1 is reduced but interaction with cyclinD3 and p21 is enhanced thus inhibiting the kinase activity of CDK4/6.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cyclin-dependent kinase 4;G1/S-specific cyclin-D3;Cyclin-dependent kinase 6	CDK4;CCND3;CDK6	None;None;CDKN6
5101	CyclinD3-CDK4-CDK6-p21 complex	Human	None	None	P11802;P30281;P38936;Q00534	1019;896;1026;1021	MI:0007-anti tag coimmunoprecipitation	GO:0000278;GO:0000082;GO:0035556;GO:0007519	mitotic cell cycle;G1/S transition of mitotic cell cycle;intracellular signal transduction;skeletal muscle tissue development	10.03.01.01;10.03.01.01.03;30.01;41.05.15	mitotic cell cycle;G1/S transition of mitotic cell cycle;cellular signalling;myogenesis	8930396	Upon myocyte differentiation subunit composition of the CDK4/6 complex is altered. Interaction with cyclinD1 is reduced but interaction with cyclinD3 and p21 is enhanced thus inhibiting the kinase activity of CDK4/6.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cyclin-dependent kinase 4;G1/S-specific cyclin-D3;Cyclin-dependent kinase inhibitor 1;Cyclin-dependent kinase 6	CDK4;CCND3;CDKN1A;CDK6	None;None;CAP20 CDKN1 CIP1 MDA6 PIC1 SDI1 WAF1;CDKN6
5107	p34(SEI-1)-CDK4-CyclinD2 complex	Human	None	None	P11802;P30279;Q9UHV2	1019;894;29950	MI:0096-pull down	GO:0006260;GO:0035556	DNA replication;intracellular signal transduction	10.01.03;30.01	DNA synthesis and replication;cellular signalling	15065884	p34(SEI1) binds to the CDK4-CyclinD2 complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cyclin-dependent kinase 4;G1/S-specific cyclin-D2;SERTA domain-containing protein 1	CDK4;CCND2;SERTAD1	None;None;SEI1 TRIPBR1
5117	RBL2 complex (DNMT1, E2F4, E2F5, HDAC1, RBL2, SUV39H1)	Human	pRb2/p130-multimolecular complex (DNMT1, E2F4/5, SuV39H1, HDAC1, RBL2)	breast carcinoma cell lines, MCF-7 (ER-positive), MDAMB-231 (ER-negative), and the mammary epithelia	O43463;P26358;Q08999;Q13547;Q15329;Q16254	6839;1786;5934;3065;1875;1874	MI:0019-coimmunoprecipitation;MI:0047-far western blotting;MI:0402-chromatin immunoprecipitation assay	GO:0006351;GO:0030284	DNA-templated transcription;nuclear estrogen receptor activity	11	TRANSCRIPTION	12789259	pRb2/p130-E2F4/5-HDAC1-SUV39H1-p300 and pRb2/p130-E2F4/5-HDAC1-SUV39H1-DNMT1 multimolecular complexes mediate the transcription of estrogen receptor-alpha in breast cancer.	breast cancer	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone-lysine N-methyltransferase SUV39H1;DNA;Retinoblastoma-like protein 2;Histone deacetylase 1;Transcription factor E2F5;Transcription factor E2F4	SUV39H1;DNMT1;RBL2;HDAC1;E2F5;E2F4	KMT1A, SUV39H;AIM CXXC9 DNMT;RB2;RPD3L1;None;None
5118	RBL2 complex (EP300, E2F4, E2F5, HDAC1, RBL2, SUV39H1)	Human	pRb2/p130-multimolecular complex (RB2, E2F4,E2F5, HDAC1, SUV39H1, P300)	breast carcinoma cell lines, MCF-7 (ER-positive), MDAMB-231 (ER-negative), and the mammary epithelia	O43463;Q08999;Q09472;Q13547;Q15329;Q16254	6839;5934;2033;3065;1875;1874	MI:0019-coimmunoprecipitation;MI:0047-far western blotting;MI:0402-chromatin immunoprecipitation assay	GO:0006351;GO:0030284	DNA-templated transcription;nuclear estrogen receptor activity	11	TRANSCRIPTION	12789259	pRb2/p130-E2F4/5-HDAC1-SUV39H1-p300 and pRb2/p130-E2F4/5-HDAC1-SUV39H1-DNMT1 multimolecular complexes mediate the transcription of estrogen receptor-alpha in breast cancer.	breast cancer	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone-lysine N-methyltransferase SUV39H1;Retinoblastoma-like protein 2;Histone acetyltransferase p300;Histone deacetylase 1;Transcription factor E2F5;Transcription factor E2F4	SUV39H1;RBL2;EP300;HDAC1;E2F5;E2F4	KMT1A, SUV39H;RB2;P300;RPD3L1;None;None
5144	E2F1-p107-cyclinA complex	Human	None	None	P20248;P28749;Q01094	890;5933;1869	MI:0006-anti bait coimmunoprecipitation;MI:0412-electrophoretic mobility supershift assay	GO:0000084;GO:2001141;GO:0006355	mitotic S phase;regulation of RNA biosynthetic process;regulation of DNA-templated transcription	10.03.01.01.05;11.02.03.04	S phase of mitotic cell cycle;transcriptional control	1531040	p107 forms a complex with E2F1 and cyclin A in the S phase of the cell cycle.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cyclin-A2;Retinoblastoma-like protein 1;Transcription factor E2F1	CCNA2;RBL1;E2F1	CCN1 CCNA;None;RBBP3
5146	RB1-TFAP2A complex	Human	None	None	P05549;P06400	7020;5925	MI:0019-coimmunoprecipitation	GO:0045893	positive regulation of DNA-templated transcription	11.02.03.04.01	transcription activation	9632747	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Transcription factor AP-2-alpha;Retinoblastoma-associated protein	TFAP2A;RB1	AP2TF TFAP2;None
5153	CTFC-TAF1 complex	Human	None	None	P49711;Q01105	10664;6418	MI:0004-affinity chromatography technology;MI:0029-cosedimentation through density gradient	GO:2001141;GO:0006355	regulation of RNA biosynthetic process;regulation of DNA-templated transcription	11.02.03.04	transcriptional control	14759373	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Transcriptional repressor CTCF;Protein SET	CTCF;SET	None;None
5154	CTCF-nucleophosmin complex	Human	None	None	P06748;P49711	4869;10664	MI:0004-affinity chromatography technology;MI:0006-anti bait coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:2001141;GO:0006355;GO:0005634	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;nucleus	11.02.03.04;70.10	transcriptional control;nucleus	14759373	CTCF and nucleophosmin work together as insularors blocking enhancer activity.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Nucleophosmin;Transcriptional repressor CTCF	NPM1;CTCF	NPM;None
5159	E2F4-p107-cyclinE complex	Human	None	MCF-7 cells	P24864;P28749;Q16254	898;5933;1874	MI:0412-electrophoretic mobility supershift assay	GO:0000082;GO:0005634	G1/S transition of mitotic cell cycle;nucleus	10.03.01.01.03;70.10	G1/S transition of mitotic cell cycle;nucleus	12096339	In proliferating MCF-7 cells the complex contains mostly cyclin A. After overexpression of cyclin E most of the complexes contain cyclin E.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	G1/S-specific cyclin-E1;Retinoblastoma-like protein 1;Transcription factor E2F4	CCNE1;RBL1;E2F4	CCNE;None;None
5160	E2F4-p130 complex	Human	None	MCF-7 cells	Q08999;Q16254	5934;1874	MI:0412-electrophoretic mobility supershift assay	GO:0000082;GO:0005634	G1/S transition of mitotic cell cycle;nucleus	10.03.01.01.03;70.10	G1/S transition of mitotic cell cycle;nucleus	12096339	After tamoxifen treatment p107 is replaced by p130.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Retinoblastoma-like protein 2;Transcription factor E2F4	RBL2;E2F4	RB2;None
5162	ELK1-SRF-ELK3 complex	Human	None	None	P11831;P19419;P41970	6722;2002;2004	MI:0413-electrophoretic mobility shift assay	GO:2001141;GO:0006355	regulation of RNA biosynthetic process;regulation of DNA-templated transcription	11.02.03.04	transcriptional control	7540136	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Serum response factor;ETS domain-containing protein Elk-1;ETS domain-containing protein Elk-3	SRF;ELK1;ELK3	None;;NET SAP2
5165	AP1G1-PACS1-FURIN complex	Human	None	HeLa cells	O43747;P09958;Q6VY07	164;5045;55690	MI:0096-pull down	GO:0006886;GO:0006605;GO:0015031;GO:0016192	intracellular protein transport;protein targeting;protein transport;vesicle-mediated transport	14.04;20.01.10;20.09.07	protein targeting, sorting and translocation;protein transport;vesicular transport (Golgi network, etc.)	11331585	The data suggest that PACS-1 functions in a connector capacity by linking acidic cluster motifs to adaptor complexes and their associated vesicle-generating machinery.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	AP-1 complex subunit gamma-1;Furin;Phosphofurin acidic cluster sorting protein 1	AP1G1;FURIN;PACS1	ADTG CLAPG1;FUR PACE PCSK3;KIAA1175
5176	MGC1-DNA-PKcs-Ku complex	Human	None	None	P12956;P13010;P78527;Q14676	2547;7520;5591;9656	MI:0006-anti bait coimmunoprecipitation;MI:0096-pull down	GO:0006281;GO:0000075;GO:0006974;GO:0005634	DNA repair;cell cycle checkpoint signaling;cellular response to DNA damage stimulus;nucleus	10.01.05.01;10.03.01.03;32.01.09;70.10	DNA repair;cell cycle checkpoints (checkpoints of morphogenesis, DNA-damage,-replication, mitotic phase and spindle);DNA damage response;nucleus	15377652	MDC1 directly interacts with the DNA-PKc-Ku complex and this interaction is required for efficient DNA-PK autophosphorylation and DNA damage repair.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	X-ray repair cross-complementing protein 6;X-ray repair cross-complementing protein 5;DNA-dependent protein kinase catalytic subunit;Mediator of DNA damage checkpoint protein 1	XRCC6;XRCC5;PRKDC;MDC1	G22P1;G22P2;HYRC HYRC1;KIAA0170 NFBD1
5177	Polycystin-1 multiprotein complex (ACTN1, CDH1, SRC, JUP, VCL, CTNNB1, PXN, BCAR1, PKD1, PTK2, TLN1)	Human	None	epithelium	P12814;P12830;P12931;P14923;P18206;P35222;P49023;P56945;P98161;Q05397;Q9Y490	87;999;6714;3728;7414;1499;5829;9564;5310;5747;7094	MI:0029-cosedimentation through density gradient	GO:0007155;GO:0030855;GO:0002009;GO:0001822	cell adhesion;epithelial cell differentiation;morphogenesis of an epithelium;kidney development	34.07;45.03.09;47.03.07.01	cell adhesion;epithelium;kidney	11113628	The results suggest that polycystin-1 complexes are present in focal adhesions in subconfluent cells  and in both focal adhesions and cell\u2013cell adherens complexes in confluent cells.	PKD1 is involved in autosomal dominant polycystic kidney disease (ADPKD).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Alpha-actinin-1;Cadherin-1;Proto-oncogene tyrosine-protein kinase Src;Junction plakoglobin;Vinculin;Catenin beta-1;Paxillin;Breast cancer anti-estrogen resistance protein 1;Polycystin-1;Focal adhesion kinase 1;Talin-1	ACTN1;CDH1;SRC;JUP;VCL;CTNNB1;PXN;BCAR1;PKD1;PTK2;TLN1	None;CDHE UVO;SRC1;CTNNG DP3;None;CTNNB;None;CAS CASS1 CRKAS;None;FAK, FAK1;KIAA1027 TLN
5178	JAK2-PAFR-TYK2 complex	Human	None	COS-7 cells, Mono Mac 1 cells	O60674;P25105;P29597	3717;5724;7297	MI:0007-anti tag coimmunoprecipitation	GO:0007259	receptor signaling pathway via JAK-STAT	30.01.05.01.01	JAK-STAT cascade	14500680	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Tyrosine-protein kinase JAK2;Platelet-activating factor receptor;Non-receptor tyrosine-protein kinase TYK2	JAK2;PTAFR;TYK2	None;PAFR;None
5179	NCOA6-DNA-PK-Ku-PARP1 complex	Human	None	None	P09874;P12956;P13010;P78527;Q14686	142;2547;7520;5591;23054	MI:0096-pull down	GO:0006281;GO:0005634	DNA repair;nucleus	10.01.05.01;70.10	DNA repair;nucleus	12519782	TRBP (NCOA6) stimulates DNA-PK kinase activity in the absence of DNA.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Poly [ADP-ribose] polymerase 1;X-ray repair cross-complementing protein 6;X-ray repair cross-complementing protein 5;DNA-dependent protein kinase catalytic subunit;Nuclear receptor coactivator 6	PARP1;XRCC6;XRCC5;PRKDC;NCOA6	ADPRT PPOL;G22P1;G22P2;HYRC HYRC1;AIB3 KIAA0181 RAP250 TRBP
5183	DNA-PK-Ku-eIF2-NF90-NF45 complex	Human	None	None	P05198;P12956;P13010;P20042;P41091;P78527;Q12905;Q12906	1965;2547;7520;8894;1968;5591;3608;3609	MI:0006-anti bait coimmunoprecipitation;MI:0412-electrophoretic mobility supershift assay	GO:0006281;GO:0006468;GO:0046777;GO:0003677;GO:0005634	DNA repair;protein phosphorylation;protein autophosphorylation;DNA binding;nucleus	10.01.05.01;14.07.03;16.03.01;70.10	DNA repair;modification by phosphorylation, dephosphorylation, autophosphorylation;DNA binding;nucleus	9442054	NF90, in complex with NF45, interacts with DNA-PKcs and Ku and promotes formation of a complex on DNA.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Eukaryotic translation initiation factor 2 subunit 1;X-ray repair cross-complementing protein 6;X-ray repair cross-complementing protein 5;Eukaryotic translation initiation factor 2 subunit 2;Eukaryotic translation initiation factor 2 subunit 3;DNA-dependent protein kinase catalytic subunit;Interleukin enhancer-binding factor 2;Interleukin enhancer-binding factor 3	EIF2S1;XRCC6;XRCC5;EIF2S2;EIF2S3;PRKDC;ILF2;ILF3	EIF2A;G22P1;G22P2;EIF2B;EIF2G;HYRC HYRC1;NF45;DRBF MPHOSPH4 NF90
5184	SWI/SNF-related chromatin-remodeling complex	Human	None	normal (C49) and RJK1412 (FRAXA) cells	P51531;P51608;Q13547;Q969G3;Q96ST3	6595;4204;3065;6605;25942	MI:0019-coimmunoprecipitation;MI:0096-pull down;MI:0402-chromatin immunoprecipitation assay	GO:0045892;GO:0006338	negative regulation of DNA-templated transcription;chromatin remodeling	11.02.03.04.03	transcription repression	15696166	Human Brahma (Brm), a catalytic component of the SWI/SNF-related chromatin-remodeling complex, associates with MeCP2 in vivo and is functionally linked with repression. Brm-containing MeCP2 corepressor complex includes HDAC1 and Sin3aon soluble chromatin. MeCP2, Brm and BAF57 coimmunoprecipitate. BAF57 was associated with the FMR1 promoter on the repressed gene in FRAXA cells.	Brm and MeCP2 assembly on chromatin occurs on methylated genes in cancer and the gene FMR1 in fragile X syndrome.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Probable global transcription activator SNF2L2;Methyl-CpG-binding protein 2;Histone deacetylase 1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1;Paired amphipathic helix protein Sin3a	SMARCA2;MECP2;HDAC1;SMARCE1;SIN3A	BAF190B BRM SNF2A SNF2L2;None;RPD3L1;BAF57;None
5189	YWHAQ-CALM1-CABIN1 complex	Human	None	None	P0DP23;P27348;Q9Y6J0	801;10971;23523	MI:0004-affinity chromatography technology	GO:0023052	signaling	30.01	cellular signalling	15902271	None	None	P62158 is obsolete. On May 10, 2017 this ID became obsolete. It can now be found as secondary accession in P0DP23, P0DP24 and P0DP25.? We will update the UniProt-IDs in our database within the next days. However, it will be only seen on the CORUM webpage until there will be a new stable release for download.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Calmodulin-1;14-3-3 protein theta;Calcineurin-binding protein cabin-1	CALM1;YWHAQ;CABIN1	CALM CAM CAM1;None;KIAA0330
5190	TIAM1-EFNB1-EPHA2 complex	Human	None	COS-1 cells	P29317;P98172;Q13009	1969;1947;7074	MI:0006-anti bait coimmunoprecipitation	GO:0022008;GO:0031175	neurogenesis;neuron projection development	41.05.13	neurogenesis	14988728	Tiam1 is required for neurite outgrowth induced by both ephrin-B1-mediated reverse signaling and EphA2-mediated forward signaling.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Ephrin type-A receptor 2;Ephrin-B1;Rho guanine nucleotide exchange factor TIAM1	EPHA2;EFNB1;TIAM1	ECK;EFL3 EPLG2 LERK2;None
5193	TNF-alpha/NF-kappa B signaling complex (CHUK, KPNA3, NFKB2, NFKBIB, REL, IKBKG,  NFKB1, NFKBIE, RELB,  NFKBIA, RELA, TNIP2)	Human	None	None	O00221;O00505;O15111;P19838;P25963;Q00653;Q01201;Q04206;Q04864;Q15653;Q8NFZ5;Q9Y6K9	4794;None;1147;4790;4792;4791;5971;5970;5966;4793;79155;8517	MI:0676-tandem affinity purification	GO:0007249;GO:0005125	I-kappaB kinase/NF-kappaB signaling;cytokine activity	30.01.05.01.04;40.02.03.01	NIK-I-kappaB/NF-kappaB cascade;cytokines (interleukines, colony stimulating factors, etc.)	14743216	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	NF-kappa-B inhibitor epsilon;Importin subunit alpha-4;Inhibitor of nuclear factor kappa-B kinase subunit alpha;Nuclear factor NF-kappa-B p105 subunit;NF-kappa-B inhibitor alpha;Nuclear factor NF-kappa-B p100 subunit;Transcription factor RelB;Transcription factor p65;Proto-oncogene c-Rel;NF-kappa-B inhibitor beta;TNFAIP3-interacting protein 2;NF-kappa-B essential modulator	NFKBIE;KPNA3;CHUK;NFKB1;NFKBIA;NFKB2;RELB;RELA;REL;NFKBIB;TNIP2;IKBKG	IKBE;QIP2;IKKA TCF16;None;IKBA MAD3 NFKBI;LYT10;None;NFKB3;None;IKBB TRIP9;ABIN2 FLIP1;FIP3, NEMO
5194	TNF-alpha/NF-kappa B signaling complex (SEC16A, CHUK, IKBKB, NFKB2, REL, IKBKG, MAP3K14, RELA, FBXW7, USP2)	Human	None	None	O14920;O15027;O15111;O75604;Q00653;Q04206;Q04864;Q969H0;Q99558;Q9Y6K9	3551;9919;1147;9099;4791;5970;5966;55294;9020;8517	MI:0676-tandem affinity purification	GO:0007249;GO:0005125	I-kappaB kinase/NF-kappaB signaling;cytokine activity	30.01.05.01.04;40.02.03.01	NIK-I-kappaB/NF-kappaB cascade;cytokines (interleukines, colony stimulating factors, etc.)	14743216	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Inhibitor of nuclear factor kappa-B kinase subunit beta;Protein transport protein Sec16A;Inhibitor of nuclear factor kappa-B kinase subunit alpha;Ubiquitin carboxyl-terminal hydrolase 2;Nuclear factor NF-kappa-B p100 subunit;Transcription factor p65;Proto-oncogene c-Rel;F-box/WD repeat-containing protein 7;Mitogen-activated protein kinase kinase kinase 14;NF-kappa-B essential modulator	IKBKB;SEC16A;CHUK;USP2;NFKB2;RELA;REL;FBXW7;MAP3K14;IKBKG	IKKB;KIAA0310 SEC16 SEC16L;IKKA TCF16;UBP41;LYT10;NFKB3;None;FBW7 FBX30 SEL10;NIK;FIP3, NEMO
5195	PTIP-HMT complex	Human	None	None	O15550;P61964;Q14686;Q15291;Q6ZW49;Q8NEZ4;Q9BTK6;Q9C005;Q9UBL3;Q9UMN6	7403;11091;23054;5929;22976;58508;79447;84661;9070;None	MI:0007-anti tag coimmunoprecipitation;MI:0071-molecular sieving	GO:0006265;GO:2001141;GO:0006355;GO:0006479;GO:0003677;GO:0051276;GO:0005634	DNA topological change;regulation of RNA biosynthetic process;regulation of DNA-templated transcription;protein methylation;DNA binding;chromosome organization;nucleus	10.01.09.05;11.02.03.04;14.07.09;16.03.01;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcriptional control;posttranslational modification of amino acids (e.g. hydroxylation, methylation);DNA binding;organization of chromosome structure;nucleus	17500065	In cells without DNA damage PTIP associates with proteins involved in regulation of gene expression.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Lysine-specific demethylase 6A;WD repeat-containing protein 5;Nuclear receptor coactivator 6;Retinoblastoma-binding protein 5;PAX-interacting protein 1;Histone-lysine N-methyltransferase 2C;PAXIP1-associated glutamate-rich protein 1;Protein dpy-30 homolog;Set1/Ash2 histone methyltransferase complex subunit ASH2;Histone-lysine N-methyltransferase 2B	KDM6A;WDR5;NCOA6;RBBP5;PAXIP1;KMT2C;PAGR1;DPY30;ASH2L;KMT2B	UTX;BIG3;AIB3 KIAA0181 RAP250 TRBP;RBQ3;PAXIP1L PTIP;HALR, KIAA1506, MLL3;C16orf53, PA1;None;ASH2L1;HRX2 KIAA0304 MLL2 MLL4 TRX2 WBP7
5196	TNF-alpha/NF-kappa B signaling complex (CHUK, BTRC, NFKB2, PPP6C, REL, CUL1, IKBKE, SAPS2, SAPS1, ANKRD28, RELA, SKP1)	Human	None	None	O00743;O15084;O15111;O75170;P63208;Q00653;Q04206;Q04864;Q13616;Q14164;Q9UPN7;Q9Y297	5537;23243;1147;9701;6500;4791;5970;5966;8454;9641;22870;8945	MI:0676-tandem affinity purification	GO:0007249;GO:0005125	I-kappaB kinase/NF-kappaB signaling;cytokine activity	30.01.05.01.04;40.02.03.01	NIK-I-kappaB/NF-kappaB cascade;cytokines (interleukines, colony stimulating factors, etc.)	14743216	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein phosphatase 6 catalytic subunit;Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A;Inhibitor of nuclear factor kappa-B kinase subunit alpha;Serine/threonine-protein phosphatase 6 regulatory subunit 2;S-phase kinase-associated protein 1;Nuclear factor NF-kappa-B p100 subunit;Transcription factor p65;Proto-oncogene c-Rel;Cullin-1;Inhibitor of nuclear factor kappa-B kinase subunit epsilon;Serine/threonine-protein phosphatase 6 regulatory subunit 1;F-box/WD repeat-containing protein 1A	PPP6C;ANKRD28;CHUK;PPP6R2;SKP1;NFKB2;RELA;REL;CUL1;IKBKE;PPP6R1;BTRC	PPP6;KIAA0379;IKKA TCF16;KIAA0685 PP6R2 SAPS2;EMC19 OCP2 SKP1A TCEB1L;LYT10;NFKB3;None;None;IKKE IKKI KIAA0151;KIAA1115 PP6R1 SAPS1;BTRCP FBW1A FBXW1A
5197	PTIP-DNA damage response complex	Human	None	None	O60934;P49959;P54132;Q12888;Q6ZW49;Q92878	4683;4361;641;7158;22976;10111	MI:0007-anti tag coimmunoprecipitation;MI:0071-molecular sieving	GO:0006281;GO:0003677;GO:0006974;GO:0005634	DNA repair;DNA binding;cellular response to DNA damage stimulus;nucleus	10.01.05.01;16.03.01;32.01.09;70.10	DNA repair;DNA binding;DNA damage response;nucleus	17500065	In cells treated with DNA damage agents, PTIP associates with proteins involved in DNA damage response and DNA repair.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Nibrin;Double-strand break repair protein MRE11;RecQ-like DNA helicase BLM;TP53-binding protein 1;PAX-interacting protein 1;DNA repair protein RAD50	NBN;MRE11;BLM;TP53BP1;PAXIP1;RAD50	NBS NBS1 P95;HNGS1 MRE11A;RECQ2 RECQL3;None;PAXIP1L PTIP;None
5198	CBP-RARA-RXRA-DNA complex, ligand stimulated	Human	None	None	P10276;P19793;Q92793	5914;6256;1387	MI:0413-electrophoretic mobility shift assay	GO:0045893;GO:0023052;GO:0005634	positive regulation of DNA-templated transcription;signaling;nucleus	11.02.03.04.01;30.01;70.10	transcription activation;cellular signalling;nucleus	8616895	The authors suggest that CBP/p300 serves as an integrator of multiple signal transduction pathways within the nucleus.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Retinoic acid receptor alpha;Retinoic acid receptor RXR-alpha;CREB-binding protein	RARA;RXRA;CREBBP	NR1B1;NR2B1;CBP
5199	Kinase maturation complex 1	Human	None	None	P07900;P08238;P27348;P31946;P34932;P61981;P62258;P63104;Q04917;Q13163;Q16543;Q6Q0C0;Q7KZI7;Q99759;Q9NUG6;Q9UHV9	3320;3326;10971;7529;3308;7532;7531;7534;7533;5607;11140;84231;2011;4215;81572;5202	MI:0676-tandem affinity purification	GO:0035556	intracellular signal transduction	30.01	cellular signalling	14743216	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-beta;14-3-3 protein theta;14-3-3 protein beta/alpha;Heat shock 70 kDa protein 4;14-3-3 protein gamma;14-3-3 protein epsilon;14-3-3 protein zeta/delta;14-3-3 protein eta;Dual specificity mitogen-activated protein kinase kinase 5;Hsp90 co-chaperone Cdc37;E3 ubiquitin-protein ligase TRAF7;Serine/threonine-protein kinase MARK2;Mitogen-activated protein kinase kinase kinase 3;p53 and DNA damage-regulated protein 1;Prefoldin subunit 2	HSP90AA1;HSP90AB1;YWHAQ;YWHAB;HSPA4;YWHAG;YWHAE;YWHAZ;YWHAH;MAP2K5;CDC37;TRAF7;MARK2;MAP3K3;PDRG1;PFDN2	HSP90A HSPC1 HSPCA;HSP90B HSPC2 HSPCB;None;None;APG2;None;None;None;YWHA1;MEK5 MKK5 PRKMK5;CDC37A;RFWD1 RNF119;EMK1;MAPKKK3 MEKK3;C20orf126 PDRG;PFD2
5209	Ubiquilin-proteasome complex	Human	None	HFK cells; HeLa cells	P25786;P25787;P60900;Q05086;Q9UHD9;Q9UMX0	5682;5683;5687;7337;29978;29979	MI:0007-anti tag coimmunoprecipitation;MI:0019-coimmunoprecipitation;MI:0047-far western blotting;MI:0051-fluorescence technology	GO:0043161;GO:0006511	proteasome-mediated ubiquitin-dependent protein catabolic process;ubiquitin-dependent protein catabolic process	14.13.01.01	proteasomal degradation (ubiquitin/proteasomal pathway)	10983987	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Proteasome subunit alpha type-1;Proteasome subunit alpha type-2;Proteasome subunit alpha type-6;Ubiquitin-protein ligase E3A;Ubiquilin-2;Ubiquilin-1	PSMA1;PSMA2;PSMA6;UBE3A;UBQLN2;UBQLN1	HC2 NU PROS30 PSC2;HC3 PSC3;PROS27;E6AP EPVE6AP HPVE6A;N4BP4 PLIC2;DA41 PLIC1
5210	TANK-TRAF2-TRAF3 complex	Human	None	None	Q12933;Q13114;Q92844	7186;7187;10010	MI:0676-tandem affinity purification	GO:0023052	signaling	30.01	cellular signalling	14743216	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	TNF receptor-associated factor 2;TNF receptor-associated factor 3;TRAF family member-associated NF-kappa-B activator	TRAF2;TRAF3;TANK	TRAP3;CAP-1 CRAF1 TRAFAMN;ITRAF TRAF2
5212	Kinase maturation complex 2	Human	None	None	A7MCY6;P07900;P08238;Q12933;Q16543;Q92844;Q9H6S1;Q9UHD2	9755;3320;3326;7186;11140;10010;64343;29110	MI:0676-tandem affinity purification	GO:0035556	intracellular signal transduction	30.01	cellular signalling	14743216	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	TANK-binding kinase 1-binding protein 1;Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-beta;TNF receptor-associated factor 2;Hsp90 co-chaperone Cdc37;TRAF family member-associated NF-kappa-B activator;5-azacytidine-induced protein 2;Serine/threonine-protein kinase TBK1	TBKBP1;HSP90AA1;HSP90AB1;TRAF2;CDC37;TANK;AZI2;TBK1	KIAA0775 SINTBAD;HSP90A HSPC1 HSPCA;HSP90B HSPC2 HSPCB;TRAP3;CDC37A;ITRAF TRAF2;NAP1 TBKBP2;NAK
5213	AAA\u2013ATPase complex, peroxisomal	Human	PEX1-PEX6-PEX26 complex	HEK 293 cells, CHO cells	O43933;Q13608;Q7Z412	5189;5190;55670	MI:0006-anti bait coimmunoprecipitation;MI:0007-anti tag coimmunoprecipitation	GO:0007031;GO:0005777;GO:0000425;GO:0030242	peroxisome organization;peroxisome;pexophagy;autophagy of peroxisome	42.19;70.19	peroxisome;peroxisome	12717447	The results indicate that Pex26 anchors Pex6 and Pex1 through Pex26-Pex6 and Pex6-Pex1 interactions (PMID: 12717447). The peroxisomal AAA\u2013ATPase complex consisting of PEX1, PEX6, and PEX26 prevents pexophagy and peroxisome biogenesis disorder development (PMID: 32917959).	The complex is involved in peroxisome biogenesis disorders (PBDs), such as Zellweger syndrome and neonatal adrenoleukodystrophy.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Peroxisome biogenesis factor 1;Peroxisome assembly factor 2;Peroxisome assembly protein 26	PEX1;PEX6;PEX26	None;PXAAA1;None
5215	CS-MAP3K7IP1-MAP3K7IP2 complex	Human	None	None	O75390;Q15750;Q9NYJ8	1431;10454;23118	MI:0676-tandem affinity purification	GO:0035556	intracellular signal transduction	30.01	cellular signalling	14743216	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Citrate synthase, mitochondrial;TGF-beta-activated kinase 1 and MAP3K7-binding protein 1;TGF-beta-activated kinase 1 and MAP3K7-binding protein 2	CS;TAB1;TAB2	None;MAP3K7IP1;KIAA0733, MAP3K7IP2
5217	Calreticulin homodimer complex	Human	None	HeLa cells	P27797	811	MI:0019-coimmunoprecipitation	GO:0009408;GO:0051259;GO:0006950	response to heat;protein complex oligomerization;response to stress	32.01.05;32.01	heat shock response;stress response	15383281	Calreticulin is an endoplasmic reticulum (ER)-resident chaperone that is upregulated in response to various types of ER stress. In cells, calreticulin binds to deglycosylated major histocompatibility complex class I heavy chains when significant levels of calreticulin oligomerization intermediates are induced. Disulfide-linked dimers of calreticulin were observed in HeLa cells. The protein complex consists of several identical subunits (oligomerization).	None	None	Homo sapiens (Human)	Calreticulin	CALR	CRTC
5220	CHUK-IQGAP2-AKAP8L-RELA-TNIP2 complex	Human	None	None	O15111;Q04206;Q13576;Q8NFZ5;Q9ULX6	1147;5970;10788;79155;26993	MI:0676-tandem affinity purification	GO:0035556	intracellular signal transduction	30.01	cellular signalling	14743216	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Inhibitor of nuclear factor kappa-B kinase subunit alpha;Transcription factor p65;Ras GTPase-activating-like protein IQGAP2;TNFAIP3-interacting protein 2;A-kinase anchor protein 8-like	CHUK;RELA;IQGAP2;TNIP2;AKAP8L	IKKA TCF16;NFKB3;None;ABIN2 FLIP1;NAKAP NAKAP95
5222	p14-Mp1-MEK1 complex	Human	None	HeLa cells	Q02750;Q9UHA4;Q9Y2Q5	5604;8649;28956	MI:0007-anti tag coimmunoprecipitation	GO:0000165	MAPK cascade	30.01.05.01.03	MAPKKK cascade	11266467	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Dual specificity mitogen-activated protein kinase kinase 1;Ragulator complex protein LAMTOR3;Ragulator complex protein LAMTOR2	MAP2K1;LAMTOR3;LAMTOR2	MEK1 PRKMK1;MAP2K1IP1 MAPKSP1;MAPBPIP ROBLD3
5223	Casein kinase II (beta-dimer, alpha'-dimer)	Human	None	in vitro	P19784;P67870	1459;1460	MI:0018-two hybrid	GO:0006468	protein phosphorylation	14.07.03	modification by phosphorylation, dephosphorylation, autophosphorylation	7768894	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Casein kinase II subunit alpha';Casein kinase II subunit beta	CSNK2A2;CSNK2B	CK2A2;CK2N G5A
5224	Casein kinase II (beta-dimer, alpha, alpha')	Human	CKII complex	in vitro	P19784;P67870;P68400	1459;1460;1457	MI:0018-two hybrid	GO:0006468	protein phosphorylation	14.07.03	modification by phosphorylation, dephosphorylation, autophosphorylation	7768894	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Casein kinase II subunit alpha';Casein kinase II subunit beta;Casein kinase II subunit alpha	CSNK2A2;CSNK2B;CSNK2A1	CK2A2;CK2N G5A;CK2A1
5225	Casein kinase II (beta-dimer, alpha-dimer)	Human	None	in vitro	P67870;P68400	1460;1457	MI:0018-two hybrid	GO:0006468	protein phosphorylation	14.07.03	modification by phosphorylation, dephosphorylation, autophosphorylation	7768894	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Casein kinase II subunit beta;Casein kinase II subunit alpha	CSNK2B;CSNK2A1	CK2N G5A;CK2A1
5226	p14-Mp1-ERK2 complex	Human	None	None	P28482;Q9UHA4;Q9Y2Q5	5594;8649;28956	MI:0007-anti tag coimmunoprecipitation	GO:0000165	MAPK cascade	30.01.05.01.03	MAPKKK cascade	11266467	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mitogen-activated protein kinase 1;Ragulator complex protein LAMTOR3;Ragulator complex protein LAMTOR2	MAPK1;LAMTOR3;LAMTOR2	ERK2 PRKM1 PRKM2;MAP2K1IP1 MAPKSP1;MAPBPIP ROBLD3
5228	REL-MAP3K8-RELA-TNIP2-PAPOLA complex	Human	None	None	P41279;P51003;Q04206;Q04864;Q8NFZ5	1326;10914;5970;5966;79155	MI:0676-tandem affinity purification	GO:0007249	I-kappaB kinase/NF-kappaB signaling	30.01.05.01.04	NIK-I-kappaB/NF-kappaB cascade	14743216	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mitogen-activated protein kinase kinase kinase 8;Poly(A) polymerase alpha;Transcription factor p65;Proto-oncogene c-Rel;TNFAIP3-interacting protein 2	MAP3K8;PAPOLA;RELA;REL;TNIP2	COT ESTF;PAP;NFKB3;None;ABIN2 FLIP1
5229	RPA complex	Human	replication complex	None	P15927;P27694;P35244	6118;6117;6119	MI:0029-cosedimentation through density gradient;MI:0091-chromatography technology	GO:0006260;GO:0003677	DNA replication;DNA binding	10.01.03;16.03.01	DNA synthesis and replication;DNA binding	2833742	RPA facilitates unwinding of dsDNA.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Replication protein A 32 kDa subunit;Replication protein A 70 kDa DNA-binding subunit;Replication protein A 14 kDa subunit	RPA2;RPA1;RPA3	REPA2 RPA32 RPA34;REPA1 RPA70;REPA3 RPA14
5230	CHUK-NFKB2-REL-IKBKG-SPAG9-NFKB1-NFKBIE-COPB2-TNIP1-NFKBIA-RELA-TNIP2 complex	Human	None	None	O00221;O15111;O60271;P19838;P25963;P35606;Q00653;Q04206;Q04864;Q15025;Q8NFZ5;Q9Y6K9	4794;1147;9043;4790;4792;9276;4791;5970;5966;10318;79155;8517	MI:0676-tandem affinity purification	GO:0007249	I-kappaB kinase/NF-kappaB signaling	30.01.05.01.04	NIK-I-kappaB/NF-kappaB cascade	14743216	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	NF-kappa-B inhibitor epsilon;Inhibitor of nuclear factor kappa-B kinase subunit alpha;C-Jun-amino-terminal kinase-interacting protein 4;Nuclear factor NF-kappa-B p105 subunit;NF-kappa-B inhibitor alpha;Coatomer subunit beta';Nuclear factor NF-kappa-B p100 subunit;Transcription factor p65;Proto-oncogene c-Rel;TNFAIP3-interacting protein 1;TNFAIP3-interacting protein 2;NF-kappa-B essential modulator	NFKBIE;CHUK;SPAG9;NFKB1;NFKBIA;COPB2;NFKB2;RELA;REL;TNIP1;TNIP2;IKBKG	IKBE;IKKA TCF16;HSS KIAA0516 MAPK8IP4 SYD1;None;IKBA MAD3 NFKBI;None;LYT10;NFKB3;None;KIAA0113 NAF1;ABIN2 FLIP1;FIP3, NEMO
5231	53BP1-containing complex	Human	53BP1-Ku70-Ku80-RPA1-RPA2 complex	None	P12956;P13010;P15927;P27694;Q12888	2547;7520;6118;6117;7158	MI:0007-anti tag coimmunoprecipitation	GO:0006281;GO:0003677;GO:0006974	DNA repair;DNA binding;cellular response to DNA damage stimulus	10.01.05.01;16.03.01;32.01.09	DNA repair;DNA binding;DNA damage response	15856006	53BP1 is involved in DNA damage-induced RPA2 phosphorylation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	X-ray repair cross-complementing protein 6;X-ray repair cross-complementing protein 5;Replication protein A 32 kDa subunit;Replication protein A 70 kDa DNA-binding subunit;TP53-binding protein 1	XRCC6;XRCC5;RPA2;RPA1;TP53BP1	G22P1;G22P2;REPA2 RPA32 RPA34;REPA1 RPA70;None
5232	TNF-alpha/Nf-kappa B signaling complex (RPL6, RPL30, RPS13, CHUK, DDX3X, NFKB2, NFKBIB, REL, IKBKG, NFKB1, MAP3K8, RELB, GLG1, NFKBIA, RELA, TNIP2,  GTF2I)	Human	None	None	O00571;O15111;P19838;P25963;P41279;P62277;P62888;P78347;Q00653;Q01201;Q02878;Q04206;Q04864;Q15653;Q8NFZ5;Q92896;Q9Y6K9	1654;1147;4790;4792;1326;6207;6156;2969;4791;5971;6128;5970;5966;4793;79155;2734;8517	MI:0676-tandem affinity purification	GO:0007249;GO:0005125	I-kappaB kinase/NF-kappaB signaling;cytokine activity	30.01.05.01.04;40.02.03.01	NIK-I-kappaB/NF-kappaB cascade;cytokines (interleukines, colony stimulating factors, etc.)	14743216	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	ATP-dependent RNA helicase DDX3X;Inhibitor of nuclear factor kappa-B kinase subunit alpha;Nuclear factor NF-kappa-B p105 subunit;NF-kappa-B inhibitor alpha;Mitogen-activated protein kinase kinase kinase 8;40S ribosomal protein S13;60S ribosomal protein L30;General transcription factor II-I;Nuclear factor NF-kappa-B p100 subunit;Transcription factor RelB;60S ribosomal protein L6;Transcription factor p65;Proto-oncogene c-Rel;NF-kappa-B inhibitor beta;TNFAIP3-interacting protein 2;Golgi apparatus protein 1;NF-kappa-B essential modulator	DDX3X;CHUK;NFKB1;NFKBIA;MAP3K8;RPS13;RPL30;GTF2I;NFKB2;RELB;RPL6;RELA;REL;NFKBIB;TNIP2;GLG1;IKBKG	DBX DDX3;IKKA TCF16;None;IKBA MAD3 NFKBI;COT ESTF;None;None;BAP135 WBSCR6;LYT10;None;TXREB1;NFKB3;None;IKBB TRIP9;ABIN2 FLIP1;CFR1 ESL1 MG160;FIP3, NEMO
5233	TNF-alpha/NF-kappa B signaling complex 5	Human	None	None	O14920;O15111;O15446;O95602;P0DPB5;P19838;P23508;P42704;P46199;P52292;P52434;P62875;P63208;Q00653;Q04206;Q04864;Q13576;Q13616;Q15653;Q16342;Q9GZS1;Q9H9Y6;Q9UJF2;Q9UKB1;Q9Y6K9	3551;1147;10849;25885;51082;4790;4163;10128;4528;3838;5437;5441;6500;4791;5970;5966;10788;8454;4793;5134;64425;84172;9462;23291;8517	MI:0676-tandem affinity purification	GO:0007249;GO:0005125	I-kappaB kinase/NF-kappaB signaling;cytokine activity	30.01.05.01.04;40.02.03.01	NIK-I-kappaB/NF-kappaB cascade;cytokines (interleukines, colony stimulating factors, etc.)	14743216	None	None	Q9Y2S0 is obsolete. On November 22, 2017 this entry became obsolete. It can now be found as secondary accession in P0DPB5 and P0DPB6.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Inhibitor of nuclear factor kappa-B kinase subunit beta;Inhibitor of nuclear factor kappa-B kinase subunit alpha;DNA-directed RNA polymerase I subunit RPA34;DNA-directed RNA polymerase I subunit RPA1;Protein POLR1D, isoform 2;Nuclear factor NF-kappa-B p105 subunit;Colorectal mutant cancer protein;Leucine-rich PPR motif-containing protein, mitochondrial;Translation initiation factor IF-2, mitochondrial;Importin subunit alpha-1;DNA-directed RNA polymerases I, II, and III subunit RPABC3;DNA-directed RNA polymerases I, II, and III subunit RPABC5;S-phase kinase-associated protein 1;Nuclear factor NF-kappa-B p100 subunit;Transcription factor p65;Proto-oncogene c-Rel;Ras GTPase-activating-like protein IQGAP2;Cullin-1;NF-kappa-B inhibitor beta;Programmed cell death protein 2;DNA-directed RNA polymerase I subunit RPA49;DNA-directed RNA polymerase I subunit RPA2;Ras GTPase-activating protein nGAP;F-box/WD repeat-containing protein 11;NF-kappa-B essential modulator	IKBKB;CHUK;POLR1G;POLR1A;POLR1D;NFKB1;MCC;LRPPRC;MTIF2;KPNA2;POLR2H;POLR2L;SKP1;NFKB2;RELA;REL;IQGAP2;CUL1;NFKBIB;PDCD2;POLR1E;POLR1B;RASAL2;FBXW11;IKBKG	IKKB;IKKA TCF16;ASE1 CAST CD3EAP PAF49;None;None;None;None;LRP130;None;RCH1, SRP1;None;None;EMC19 OCP2 SKP1A TCEB1L;LYT10;NFKB3;None;None;None;IKBB TRIP9;RP8 ZMYND7;PAF53 PRAF1;None;NGAP;BTRCP2 FBW1B FBXW1B KIAA0696;FIP3, NEMO
5234	CDC37-HSP90AB1-HSP90AA1-IKBKB-KIAA1967 complex	Human	None	HEK293 cells	O14920;P07900;P08238;Q16543;Q8N163	3551;3320;3326;11140;57805	MI:0676-tandem affinity purification	GO:0007249	I-kappaB kinase/NF-kappaB signaling	30.01.05.01.04	NIK-I-kappaB/NF-kappaB cascade	14743216	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Inhibitor of nuclear factor kappa-B kinase subunit beta;Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-beta;Hsp90 co-chaperone Cdc37;Cell cycle and apoptosis regulator protein 2	IKBKB;HSP90AA1;HSP90AB1;CDC37;CCAR2	IKKB;HSP90A HSPC1 HSPCA;HSP90B HSPC2 HSPCB;CDC37A;DBC1 KIAA1967
5235	WRN-Ku70-Ku80-PARP1 complex	Human	None	HEK 293T cells	P09874;P12956;P13010;Q14191	142;2547;7520;7486	MI:0007-anti tag coimmunoprecipitation;MI:0071-molecular sieving;MI:0226-ion exchange chromatography	GO:0003677;GO:0006974;GO:0005634	DNA binding;cellular response to DNA damage stimulus;nucleus	16.03.01;32.01.09;70.10	DNA binding;DNA damage response;nucleus	14734561	PARP1 regulates the exonucleolytic activity of WRN.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Poly [ADP-ribose] polymerase 1;X-ray repair cross-complementing protein 6;X-ray repair cross-complementing protein 5;Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	PARP1;XRCC6;XRCC5;WRN	ADPRT PPOL;G22P1;G22P2;RECQ3 RECQL2
5239	CAP(C)-CAP(E) complex	Human	SMC2-SMC4 complex	None	O95347;Q9NTJ3	10592;10051	MI:0006-anti bait coimmunoprecipitation	GO:0000279;GO:0030261;GO:0005634;GO:0000278	M phase;chromosome condensation;nucleus;mitotic cell cycle	10.03.01.01.11;10.03.04.03;70.10;10.03.01.01	M phase;chromosome condensation;nucleus;mitotic cell cycle	9789013	CAP(C)-CAP(E) complex is required for mitotic chromosome condensation.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Structural maintenance of chromosomes protein 2;Structural maintenance of chromosomes protein 4	SMC2;SMC4	CAPE SMC2L1;CAPC SMC4L1
5241	SMC1-SMC3 complex	Human	None	None	Q14683;Q9UQE7	8243;9126	MI:0006-anti bait coimmunoprecipitation	GO:0000279;GO:0005634;GO:0000278	M phase;nucleus;mitotic cell cycle	10.03.01.01.11;70.10;10.03.01.01	M phase;nucleus;mitotic cell cycle	9789013	SMC1-SMC3 complex is required for metaphase progression in mitotic cells.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 3	SMC1A;SMC3	DXS423E KIAA0178 SB1.8 SMC1 SMC1L1;BAM BMH CSPG6 SMC3L1
5243	XRCC1-LIG3-PNK-TDP1 complex	Human	None	None	P18887;P49916;Q96T60;Q9NUW8	7515;3980;11284;55775	MI:0006-anti bait coimmunoprecipitation	GO:0006281	DNA repair	10.01.05.01	DNA repair	15744309	None	TDP1 is involved in Spinocerebellar ataxia with axonal neuropathy (SCAN1).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA repair protein XRCC1;DNA ligase 3;Bifunctional polynucleotide phosphatase/kinase;Tyrosyl-DNA phosphodiesterase 1	XRCC1;LIG3;PNKP;TDP1	None;None;None;None
5244	Dolichol-phosphate mannose (DPM) synthase	Human	None	None	O60762;O94777;Q9P2X0	8813;8818;54344	MI:0004-affinity chromatography technology	GO:0006486;GO:0042125;GO:0005783	protein glycosylation;protein galactosylation;endoplasmic reticulum	14.07.02;70.07	modification with sugar residues (e.g. glycosylation, deglycosylation);endoplasmic reticulum	10835346	The results indicate that DPM2 stabilizes DPM3 and DPM3 stabilizes DPM1.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Dolichol-phosphate mannosyltransferase subunit 1;Dolichol phosphate-mannose biosynthesis regulatory protein;Dolichol-phosphate mannosyltransferase subunit 3	DPM1;DPM2;DPM3	None;None;None
5251	Ku-ORC complex	Human	None	HCT116 cells	O43929;P12956;P13010;Q13416;Q9UBD5;Q9Y5N6	5000;2547;7520;4999;23595;23594	MI:0006-anti bait coimmunoprecipitation;MI:0402-chromatin immunoprecipitation assay	GO:0006267;GO:0003688;GO:0003677;GO:0005524;GO:0005694	pre-replicative complex assembly involved in nuclear cell cycle DNA replication;DNA replication origin binding;DNA binding;ATP binding;chromosome	10.01.03.03;16.03.01;16.19.03;70.10.03	ori recognition and priming complex formation;DNA binding;ATP binding;chromosome	15910003	Ku associates specifically with DNA replication origins in vivo in a cell cycle dependent manner, its association being maximal in late G1 phase and decreasing as cells enter S phase (PMID:11694575).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Origin recognition complex subunit 4;X-ray repair cross-complementing protein 6;X-ray repair cross-complementing protein 5;Origin recognition complex subunit 2;Origin recognition complex subunit 3;Origin recognition complex subunit 6	ORC4;XRCC6;XRCC5;ORC2;ORC3;ORC6	ORC4L;G22P1;G22P2;ORC2L;LATHEO ORC3L;ORC6L
5253	MNK1-eIF4F complex	Human	None	HEK 293T cells	P06730;P60842;Q04637;Q9BUB5	1977;1973;1981;8569	MI:0006-anti bait coimmunoprecipitation	GO:0006413;GO:0003723	translational initiation;RNA binding	12.04.01;16.03.03	translation initiation;RNA binding	9878069	Mnk1 is associated with the eIF4F complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Eukaryotic translation initiation factor 4E;Eukaryotic initiation factor 4A-I;Eukaryotic translation initiation factor 4 gamma 1;MAP kinase-interacting serine/threonine-protein kinase 1	EIF4E;EIF4A1;EIF4G1;MKNK1	EIF4EL1 EIF4F;DDX2A EIF4A;EIF4F EIF4G EIF4GI;MNK1
5260	CTNNB1-EP300-HADAC6-SUMO1-TCF4 complex	Human	None	human cancer cells (HCT116 cells; SW480 cells; LNCaP cells; PC3 cells; MCF7 cells)	P15884;P35222;P63165;Q09472;Q9UBN7	6925;1499;7341;2033;10013	MI:0019-coimmunoprecipitation;MI:0047-far western blotting;MI:0402-chromatin immunoprecipitation assay	GO:0006351	DNA-templated transcription	11	TRANSCRIPTION	15782138	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transcription factor 4;Catenin beta-1;Small ubiquitin-related modifier 1;Histone acetyltransferase p300;Histone deacetylase 6	TCF4;CTNNB1;SUMO1;EP300;HDAC6	BHLHB19 ITF2 SEF2;CTNNB;SMT3C SMT3H3 UBL1;P300;KIAA0901
5261	CTNNB1-EP300-TCF4 complex	Human	None	human cancer cells (HCT116 cells; SW480 cells; LNCaP cells; PC3 cells; MCF7 cells)	P15884;P35222;Q09472	6925;1499;2033	MI:0019-coimmunoprecipitation;MI:0047-far western blotting;MI:0402-chromatin immunoprecipitation assay	GO:0006351	DNA-templated transcription	11	TRANSCRIPTION	15782138	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transcription factor 4;Catenin beta-1;Histone acetyltransferase p300	TCF4;CTNNB1;EP300	BHLHB19 ITF2 SEF2;CTNNB;P300
5262	CTNNB1-TCF4 complex	Human	None	human cancer cells (HCT116 cells; SW480 cells; LNCaP cells; PC3 cells; MCF7 cells)	P15884;P35222	6925;1499	MI:0019-coimmunoprecipitation;MI:0047-far western blotting;MI:0402-chromatin immunoprecipitation assay	GO:0006351	DNA-templated transcription	11	TRANSCRIPTION	15782138	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Transcription factor 4;Catenin beta-1	TCF4;CTNNB1	BHLHB19 ITF2 SEF2;CTNNB
5264	CTNNB1-CREBBP-TCF4 complex	Human	None	human cancer cells (HCT116 cells; SW480 cells; LNCaP cells; PC3 cells; MCF7 cells)	P15884;P35222;Q92793	6925;1499;1387	MI:0019-coimmunoprecipitation;MI:0047-far western blotting;MI:0402-chromatin immunoprecipitation assay	GO:0006351	DNA-templated transcription	11	TRANSCRIPTION	15782138	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transcription factor 4;Catenin beta-1;CREB-binding protein	TCF4;CTNNB1;CREBBP	BHLHB19 ITF2 SEF2;CTNNB;CBP
5266	TNF-alpha/NF-kappa B signaling complex 6	Human	None	None	O14920;O15111;P07900;P08238;P22087;P36578;P62277;P62280;P62888;P62917;Q02878;Q16543;Q99558;Q9Y6K9	3551;1147;3320;3326;2091;6124;6207;6205;6156;6132;6128;11140;9020;8517	MI:0676-tandem affinity purification	GO:0007249;GO:0005125	I-kappaB kinase/NF-kappaB signaling;cytokine activity	30.01.05.01.04;40.02.03.01	NIK-I-kappaB/NF-kappaB cascade;cytokines (interleukines, colony stimulating factors, etc.)	14743216	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Inhibitor of nuclear factor kappa-B kinase subunit beta;Inhibitor of nuclear factor kappa-B kinase subunit alpha;Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-beta;rRNA 2'-O-methyltransferase fibrillarin;60S ribosomal protein L4;40S ribosomal protein S13;40S ribosomal protein S11;60S ribosomal protein L30;60S ribosomal protein L8;60S ribosomal protein L6;Hsp90 co-chaperone Cdc37;Mitogen-activated protein kinase kinase kinase 14;NF-kappa-B essential modulator	IKBKB;CHUK;HSP90AA1;HSP90AB1;FBL;RPL4;RPS13;RPS11;RPL30;RPL8;RPL6;CDC37;MAP3K14;IKBKG	IKKB;IKKA TCF16;HSP90A HSPC1 HSPCA;HSP90B HSPC2 HSPCB;FIB1 FLRN;RPL1;None;None;None;None;TXREB1;CDC37A;NIK;FIP3, NEMO
5267	VHL-VDU1-TCEB1-TCEB2 complex	Human	None	None	P40337;Q15369;Q15370;Q8TEY7	7428;6921;6923;23032	MI:0007-anti tag coimmunoprecipitation	GO:0043161;GO:0006511	proteasome-mediated ubiquitin-dependent protein catabolic process;ubiquitin-dependent protein catabolic process	14.13.01.01	proteasomal degradation (ubiquitin/proteasomal pathway)	11739384	Only in the presence of VHL, VDU1 could be precipitated along with VHL, Elongin B and Elongin C.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	von Hippel-Lindau disease tumor suppressor;Elongin-C;Elongin-B;Ubiquitin carboxyl-terminal hydrolase 33	VHL;ELOC;ELOB;USP33	None;TCEB1;TCEB2;KIAA1097 VDU1
5268	TNF-alpha/NF-kappa B signaling complex 7	Human	None	None	O43318;P07900;P08238;Q13451;Q15750;Q16543;Q8N5C8;Q9NYJ8	6885;3320;3326;2289;10454;11140;257397;23118	MI:0676-tandem affinity purification	GO:0007249;GO:0005125	I-kappaB kinase/NF-kappaB signaling;cytokine activity	30.01.05.01.04;40.02.03.01	NIK-I-kappaB/NF-kappaB cascade;cytokines (interleukines, colony stimulating factors, etc.)	14743216	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mitogen-activated protein kinase kinase kinase 7;Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-beta;Peptidyl-prolyl cis-trans isomerase FKBP5;TGF-beta-activated kinase 1 and MAP3K7-binding protein 1;Hsp90 co-chaperone Cdc37;TGF-beta-activated kinase 1 and MAP3K7-binding protein 3;TGF-beta-activated kinase 1 and MAP3K7-binding protein 2	MAP3K7;HSP90AA1;HSP90AB1;FKBP5;TAB1;CDC37;TAB3;TAB2	TAK1;HSP90A HSPC1 HSPCA;HSP90B HSPC2 HSPCB;AIG6 FKBP51;MAP3K7IP1;CDC37A;MAP3K7IP3;KIAA0733, MAP3K7IP2
5269	TNF-alpha/NF-kappa B signaling complex 8	Human	None	None	P07900;P08238;Q13451;Q14164;Q16543;Q86UP2	3320;3326;2289;9641;11140;3895	MI:0676-tandem affinity purification	GO:0007249;GO:0005125	I-kappaB kinase/NF-kappaB signaling;cytokine activity	30.01.05.01.04;40.02.03.01	NIK-I-kappaB/NF-kappaB cascade;cytokines (interleukines, colony stimulating factors, etc.)	14743216	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-beta;Peptidyl-prolyl cis-trans isomerase FKBP5;Inhibitor of nuclear factor kappa-B kinase subunit epsilon;Hsp90 co-chaperone Cdc37;Kinectin	HSP90AA1;HSP90AB1;FKBP5;IKBKE;CDC37;KTN1	HSP90A HSPC1 HSPCA;HSP90B HSPC2 HSPCB;AIG6 FKBP51;IKKE IKKI KIAA0151;CDC37A;CG1 KIAA0004
5273	VHL-TBP1-HIF1A complex	Human	None	HEK 293 cells, RCC4-VHL cells	P17980;P40337;Q16665	5702;7428;3091	MI:0007-anti tag coimmunoprecipitation	GO:0043161;GO:0006511;GO:0000302;GO:0006979	proteasome-mediated ubiquitin-dependent protein catabolic process;ubiquitin-dependent protein catabolic process;response to reactive oxygen species;response to oxidative stress	14.13.01.01;32.01.01	proteasomal degradation (ubiquitin/proteasomal pathway);oxidative stress response	14556007	TBP-1 associates with the beta-domain of VHL and complexes with VHL and Hif1-alpha in vivo. The ability of VHL to degrade Hif1-alpha depends in part on its interaction with TBP-1 and suggests a new mechanism for Hif1-alpha stabilization in some VHL-deficient tumors.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	26S proteasome regulatory subunit 6A;von Hippel-Lindau disease tumor suppressor;Hypoxia-inducible factor 1-alpha	PSMC3;VHL;HIF1A	TBP1;None;BHLHE78 MOP1 PASD8
5274	Cell-cell junction complex (ARHGAP10, CTNNA1, CTNNB1)	Human	None	HEK293 cells;  Caco-2 cells; JEG-3 cells; HeLa cells	A1A4S6;P35221;P35222	79658;1495;1499	MI:0018-two hybrid;MI:0019-coimmunoprecipitation;MI:0416-fluorescence microscopy	GO:0007043;GO:0005911	cell-cell junction assembly;cell-cell junction	42.06.04;70.06.04	intercellular junction (gap junction/adherens junction);intercellular junction (gap junction/adherens junction)	16184169	ARHGAP10 is a partner of alpha-catenin, a GAP for RhoA and Cdc42, playing a critical role in alpha-catenin recruitment to the adherens junctions and in L. monocytogenes entry. ARHGAP10 could coordinate actin dynamics at cell-cell contacts and orchestrate the formation of specific protein complexes that are required for junction formation and L. monocytogenes uptake.	None	Alpha-catenin binds to the C terminus of ARHGAP10. The beta-catenin always co-immunoprecipitated with alpha-catenin.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Rho GTPase-activating protein 10;Catenin alpha-1;Catenin beta-1	ARHGAP10;CTNNA1;CTNNB1	GRAF2;None;CTNNB
5276	HIF1A-EGLN1-OS9 complex	Human	None	HEK 293 cells	Q13438;Q16665;Q9GZT9	10956;3091;54583	MI:0019-coimmunoprecipitation	GO:2001141;GO:0006355;GO:0000302;GO:0006979	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;response to reactive oxygen species;response to oxidative stress	11.02.03.04;32.01.01	transcriptional control;oxidative stress response	15721254	The results indicate that OS-9 and PHD2 bind to different regions of HIF-1-alpha, and therefore may bind simultaneously. The results show enhanced binding of PHD2 to V5-OS-9  in the presence of HIF-1-alpha.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein OS-9;Hypoxia-inducible factor 1-alpha;Egl nine homolog 1	OS9;HIF1A;EGLN1	None;BHLHE78 MOP1 PASD8;C1orf12
5277	HIF1A-EGLN3-OS9 complex	Human	None	HEK 293 cells	Q13438;Q16665;Q9H6Z9	10956;3091;112399	MI:0096-pull down	GO:2001141;GO:0006355;GO:0000302;GO:0006979	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;response to reactive oxygen species;response to oxidative stress	11.02.03.04;32.01.01	transcriptional control;oxidative stress response	15721254	Similar to its effect on PHD2, OS-9 stimulates the binding of PHD3 to HIF-1-alpha and cooperates with PHD3 to inhibit HIF-1 transcriptional activity.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein OS-9;Hypoxia-inducible factor 1-alpha;Prolyl hydroxylase EGLN3	OS9;HIF1A;EGLN3	None;BHLHE78 MOP1 PASD8;None
5280	IGF2R-PLIN3-RAB9A complex	Human	RAB9-TIP47-MPRI complex	in vitro	O60664;P11717;P51151	10226;3482;9367	MI:0004-affinity chromatography technology	GO:0006886;GO:0006605;GO:0015031;GO:0016192	intracellular protein transport;protein targeting;protein transport;vesicle-mediated transport	14.04;20.01.10;20.09.07	protein targeting, sorting and translocation;protein transport;vesicular transport (Golgi network, etc.)	11359012	Rab9 bound to immobilized CI-MPR only in the presence of TIP47 in a concentration-dependent manner. Thus TIP47 formed a ternary complex linking the CI-MPR and Rab9.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Perilipin-3;Cation-independent mannose-6-phosphate receptor;Ras-related protein Rab-9A	PLIN3;IGF2R;RAB9A	M6PRBP1 TIP47;MPRI;RAB9
5281	Cell-cell junction complex (CDH1, CTNNB1)	Human	None	HEK293 cells; JEG-3 cells	P12830;P35222	999;1499	MI:0019-coimmunoprecipitation;MI:0047-far western blotting	GO:0007043;GO:0005911	cell-cell junction assembly;cell-cell junction	42.06.04;70.06.04	intercellular junction (gap junction/adherens junction);intercellular junction (gap junction/adherens junction)	16184169	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cadherin-1;Catenin beta-1	CDH1;CTNNB1	CDHE UVO;CTNNB
5282	BCAR1-PTK2-SRC complex	Human	CAS-SRC-FAK complex	human HEK293 epithelial cells	P12931;P56945;Q05397	6714;9564;5747	MI:0019-coimmunoprecipitation;MI:0047-far western blotting	GO:0007169;GO:0005925;GO:2001044	transmembrane receptor protein tyrosine kinase signaling pathway;focal adhesion;regulation of integrin-mediated signaling pathway	30.05.01.12	transmembrane receptor protein tyrosine kinase signalling pathways	9148935	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Proto-oncogene tyrosine-protein kinase Src;Breast cancer anti-estrogen resistance protein 1;Focal adhesion kinase 1	SRC;BCAR1;PTK2	SRC1;CAS CASS1 CRKAS;FAK, FAK1
5283	tRNA splicing endonuclease	Human	None	in vitro	Q7Z6J9;Q8NCE0;Q8WW01;Q92989;Q9BSV6	283989;80746;116461;10978;79042	MI:0004-affinity chromatography technology	GO:0008033;GO:0000398;GO:0006397;GO:0005634	tRNA processing;mRNA splicing, via spliceosome;mRNA processing;nucleus	11.04.02;11.04.03;70.10	tRNA processing;mRNA processing (splicing, 5'-, 3'-end processing);nucleus	15109492	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	tRNA-splicing endonuclease subunit Sen54;tRNA-splicing endonuclease subunit Sen2;tRNA-splicing endonuclease subunit Sen15;Polyribonucleotide 5'-hydroxyl-kinase Clp1;tRNA-splicing endonuclease subunit Sen34	TSEN54;TSEN2;TSEN15;CLP1;TSEN34	SEN54;SEN2;C1orf19 SEN15;HEAB;LENG5 SEN34
5284	RNA endonuclease (SEN2deltaEx8, SEN54, CLP1)	Human	None	in vitro	Q7Z6J9;Q8NCE0-2;Q92989	283989;80746;10978	MI:0004-affinity chromatography technology	GO:0004519;GO:0005634	endonuclease activity;nucleus	70.10	nucleus	15109492	The complex formed with variant SEN2deltaEx8 does not properly cleave pre-tRNAs, although it does retain endonucleolytic activity. It is likely that the SEN2deltaEx8-containing complex is not a tRNA splicing endonuclease but is responsible for processing as yet unknown RNA substrates.	None	TSEN2 is an alternatively spliced gene. SEN2deltaEx8 is the splice variant lacking exon 8.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	tRNA-splicing endonuclease subunit Sen54;Isoform 2 of tRNA-splicing endonuclease subunit Sen2;Polyribonucleotide 5'-hydroxyl-kinase Clp1	TSEN54;TSEN2;CLP1	SEN54;SEN2;HEAB
5285	TNF-alpha/NF-kappa B signaling complex 9	Human	None	None	O15111;P08238;Q13451;Q15653;Q16543	1147;3326;2289;4793;11140	MI:0676-tandem affinity purification	GO:0007249;GO:0005125	I-kappaB kinase/NF-kappaB signaling;cytokine activity	30.01.05.01.04;40.02.03.01	NIK-I-kappaB/NF-kappaB cascade;cytokines (interleukines, colony stimulating factors, etc.)	14743216	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Inhibitor of nuclear factor kappa-B kinase subunit alpha;Heat shock protein HSP 90-beta;Peptidyl-prolyl cis-trans isomerase FKBP5;NF-kappa-B inhibitor beta;Hsp90 co-chaperone Cdc37	CHUK;HSP90AB1;FKBP5;NFKBIB;CDC37	IKKA TCF16;HSP90B HSPC2 HSPCB;AIG6 FKBP51;IKBB TRIP9;CDC37A
5286	TNF-alpha/NF-kappa B signaling complex 10	Human	None	None	O15111;P07900;P08238;P40222;Q15653;Q16543;Q676U5;Q8IX12;Q9UHD2;Q9Y6K9	1147;3320;3326;200081;4793;11140;55054;None;29110;8517	MI:0676-tandem affinity purification	GO:0007249;GO:0005125	I-kappaB kinase/NF-kappaB signaling;cytokine activity	30.01.05.01.04;40.02.03.01	NIK-I-kappaB/NF-kappaB cascade;cytokines (interleukines, colony stimulating factors, etc.)	14743216	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Inhibitor of nuclear factor kappa-B kinase subunit alpha;Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-beta;Alpha-taxilin;NF-kappa-B inhibitor beta;Hsp90 co-chaperone Cdc37;Autophagy-related protein 16-1;Cell division cycle and apoptosis regulator protein 1;Serine/threonine-protein kinase TBK1;NF-kappa-B essential modulator	CHUK;HSP90AA1;HSP90AB1;TXLNA;NFKBIB;CDC37;ATG16L1;CCAR1;TBK1;IKBKG	IKKA TCF16;HSP90A HSPC1 HSPCA;HSP90B HSPC2 HSPCB;TXLN;IKBB TRIP9;CDC37A;APG16L;CARP1 DIS;NAK;FIP3, NEMO
5288	P53-BARD1-KU70 complex	Human	None	HEK 293T cells	P04637;P12956;Q99728	7157;2547;580	MI:0019-coimmunoprecipitation	GO:0006915;GO:0042325	apoptotic process;regulation of phosphorylation	40.10.02	apoptosis (type I programmed cell death)	15782130	The authors suggest that BARD1 facilitates the phosphorylation of p53 by binding to p53 and Ku-70, the subunit of DNA-PK, and that this is suf?cient and required for apoptosis induction.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cellular tumor antigen p53;X-ray repair cross-complementing protein 6;BRCA1-associated RING domain protein 1	TP53;XRCC6;BARD1	P53;G22P1;None
5293	ETS2-SMARCA4-INI1 complex	Human	None	MCF-7 cells	P15036;P51532;Q12824	2114;6597;6598	MI:0019-coimmunoprecipitation	GO:0045892;GO:0005634	negative regulation of DNA-templated transcription;nucleus	11.02.03.04.03;70.10	transcription repression;nucleus	12637547	Brg-1 and Ini1 could be detected in complex with ets-2 after tetracycline removal, but not in cells maintained in tetracycline.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein C-ets-2;Transcription activator BRG1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1	ETS2;SMARCA4;SMARCB1	;BAF190A BRG1 SNF2B SNF2L4;BAF47, INI1, SNF5L1
5317	LATS1-HTRA2-BIRC4 complex	Human	None	None	O43464;O95835;P98170	27429;9113;331	MI:0019-coimmunoprecipitation	GO:0008219	cell death	40.10	cell death	16007220	WARTS forms a complex with XIAP while interacting with Omi and is potentially involved in the cell death through the inhibition of XIAP.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Serine protease HTRA2, mitochondrial;Serine/threonine-protein kinase LATS1;E3 ubiquitin-protein ligase XIAP	HTRA2;LATS1;XIAP	OMI PRSS25;WARTS;API3 BIRC4 IAP3
5318	ASAP1-CTTN-PXN complex	Human	DDEF1-CTTN-PXN complex	MDA-MB-231 cells, 4T1-Luc cells	P49023;Q14247;Q9ULH1	5829;2017;50807	MI:0006-anti bait coimmunoprecipitation	GO:0007010	cytoskeleton organization	42.04	cytoskeleton/structural proteins	15719014	This co-precipitation was only detected in highly invasive cells, such as MDA-MB-231 and 4T1/luc, but was undetectable in weak or noninvasive cells, such as MDA-MB-468 and MCF7, as well as in normal mammary epithelial cells. The authors describe that AMAP1 bridges cortactin and paxillin in highly invasive cells.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Paxillin;Src substrate cortactin;Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1	PXN;CTTN;ASAP1	None;EMS1;DDEF1 KIAA1249 PAG2
5319	CDH1-CKS1B complex	Human	None	HeLa cells; 293T cells	P12830;P61024	999;1163	MI:0019-coimmunoprecipitation	GO:0000278;GO:0000151;GO:0051320	mitotic cell cycle;ubiquitin ligase complex;S phase	10.03.01.01	mitotic cell cycle	15014502	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cadherin-1;Cyclin-dependent kinases regulatory subunit 1	CDH1;CKS1B	CDHE UVO;CKS1
5320	CDH1-SKP2 complex	Human	None	HeLa cells; 293T cells	P12830;Q13309	999;6502	MI:0019-coimmunoprecipitation	GO:0000278;GO:0051320;GO:0000151	mitotic cell cycle;S phase;ubiquitin ligase complex	10.03.01.01	mitotic cell cycle	15014502	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cadherin-1;S-phase kinase-associated protein 2	CDH1;SKP2	CDHE UVO;FBXL1
5331	MDM2-TP53-YY1 complex	Human	YY1-MDM2-p53 complex	U2OS cells	P04637;P25490;Q00987	7157;7528;4193	MI:0029-cosedimentation through density gradient	GO:0016567;GO:0043161;GO:0006511	protein ubiquitination;proteasome-mediated ubiquitin-dependent protein catabolic process;ubiquitin-dependent protein catabolic process	14.07.05;14.13.01.01	modification by ubiquitination, deubiquitination;proteasomal degradation (ubiquitin/proteasomal pathway)	15210108	YY1 is a potential cofactor for MDM2 in the regulation of p53 homeostasis. The physical interaction of YY1 with MDM2 appears to be important for efficient MDM2-p53 interaction in vivo, which in turn is necessary for p53 ubiquitination.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cellular tumor antigen p53;Transcriptional repressor protein YY1;E3 ubiquitin-protein ligase Mdm2	TP53;YY1;MDM2	P53;INO80S;None
5337	ELMO1-DOCK1 complex	Human	None	None	Q14185;Q92556	1793;9844	MI:0007-anti tag coimmunoprecipitation	GO:0005515;GO:0007186;GO:0016477	protein binding;G protein-coupled receptor signaling pathway;cell migration	16.01;30.05.02.24;34.05.01	protein binding;G-protein coupled receptor signalling pathway;cell migration	12134158	Dock-ELMO complex functions as an unconventional two-part exchange factor for Rac.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Dedicator of cytokinesis protein 1;Engulfment and cell motility protein 1	DOCK1;ELMO1	None;KIAA0281
5341	ELMO1-DOCK2 complex	Human	None	None	Q92556;Q92608	9844;1794	MI:0007-anti tag coimmunoprecipitation	GO:0005515;GO:0007186;GO:0016477	protein binding;G protein-coupled receptor signaling pathway;cell migration	16.01;30.05.02.24;34.05.01	protein binding;G-protein coupled receptor signalling pathway;cell migration	12134158	Dock-ELMO complex functions as an unconventional two-part exchange factor for Rac.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Engulfment and cell motility protein 1;Dedicator of cytokinesis protein 2	ELMO1;DOCK2	KIAA0281;KIAA0209
5342	ELMO1-DOCK1-RAC1 complex	Human	None	None	P63000;Q14185;Q92556	5879;1793;9844	MI:0007-anti tag coimmunoprecipitation	GO:0005515;GO:0007186;GO:0016477	protein binding;G protein-coupled receptor signaling pathway;cell migration	16.01;30.05.02.24;34.05.01	protein binding;G-protein coupled receptor signalling pathway;cell migration	12134158	Dock-ELMO complex functions as an unconventional two-part exchange factor for Rac.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Ras-related C3 botulinum toxin substrate 1;Dedicator of cytokinesis protein 1;Engulfment and cell motility protein 1	RAC1;DOCK1;ELMO1	TC25;None;KIAA0281
5343	ELMO1-DOCK1-CRKII complex	Human	None	None	P46108;Q14185;Q92556	1398;1793;9844	MI:0007-anti tag coimmunoprecipitation	GO:0005515;GO:0007186;GO:0016477	protein binding;G protein-coupled receptor signaling pathway;cell migration	16.01;30.05.02.24;34.05.01	protein binding;G-protein coupled receptor signalling pathway;cell migration	16025104	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Adapter molecule crk;Dedicator of cytokinesis protein 1;Engulfment and cell motility protein 1	CRK;DOCK1;ELMO1	None;None;KIAA0281
5360	AGO2-FXR1-TNF(alpha)ARE-RNP complex	Human	None	None	P51114;Q9UKV8	8087;27161	MI:0004-affinity chromatography technology;MI:0006-anti bait coimmunoprecipitation;MI:0030-cross-linking study	GO:0006417;GO:0003723;GO:0005737	regulation of translation;RNA binding;cytoplasm	12.07;16.03.03;70.03	translational control;RNA binding;cytoplasm	17382880	AGO2 functions as translational activator under serum-starved conditions.	None	None	Homo sapiens (Human);Homo sapiens (Human)	RNA-binding protein FXR1;Protein argonaute-2	FXR1;AGO2	None;EIF2C2
5361	CDC20-CDC27-CDH1 complex	Human	None	HeLa cells; in vitro	P12830;P30260;Q12834	999;996;991	MI:0019-coimmunoprecipitation;MI:0047-far western blotting;MI:0400-affinity technology	GO:0000278;GO:0051322;GO:0005680	mitotic cell cycle;anaphase;anaphase-promoting complex	10.03.01.01	mitotic cell cycle	15916961	Cdc27 is required for the association of Cdc20 and Cdh1.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cadherin-1;Cell division cycle protein 27 homolog;Cell division cycle protein 20 homolog	CDH1;CDC27;CDC20	CDHE UVO;ANAPC3 D0S1430E D17S978E;None
5363	Actin-ribonucleoprotein complex (GTF2F1, HNRNPU, POLR2A)	Human	None	HeLa cells	P24928;P35269;Q00839	5430;2962;3192	MI:0004-affinity chromatography technology;MI:0019-coimmunoprecipitation;MI:0047-far western blotting	GO:0006351;GO:0003779	DNA-templated transcription;actin binding	11	TRANSCRIPTION	15711563	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA-directed RNA polymerase II subunit RPB1;General transcription factor IIF subunit 1;Heterogeneous nuclear ribonucleoprotein U	POLR2A;GTF2F1;HNRNPU	POLR2;RAP74;C1orf199 HNRPU SAFA U21.1
5367	THRB-RXRB complex	Human	None	None	P10828;P28702	7068;6257	MI:0096-pull down	GO:0009755	hormone-mediated signaling pathway	30.01.09.08	hormone mediated signal transduction	9346901	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Thyroid hormone receptor beta;Retinoic acid receptor RXR-beta	THRB;RXRB	ERBA2 NR1A2 THR1;NR2B2
5369	ATM homodimer complex	Human	None	None	Q13315	472	MI:0029-cosedimentation through density gradient	GO:0006281	DNA repair	10.01.05.01	DNA repair	15790808	None	None	None	Homo sapiens (Human)	Serine-protein kinase ATM	ATM	None
5370	ERAP1-ERAP2 complex	Human	None	None	Q6P179;Q9NZ08	64167;51752	MI:0019-coimmunoprecipitation	GO:0019882	antigen processing and presentation	36.25.16.03.05	antigen presentation / processing	15908954	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Endoplasmic reticulum aminopeptidase 2;Endoplasmic reticulum aminopeptidase 1	ERAP2;ERAP1	LRAP;APPILS ARTS1 KIAA0525
5371	Grancalcin-sorcin complex	Human	None	human umbilical vein endothelial cells	P28676;P30626	25801;6717	MI:0018-two hybrid;MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0005509	calcium ion binding	16.17.01	calcium binding	12804766	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Grancalcin;Sorcin	GCA;SRI	GCL;None
5372	Sorcin homodimer complex	Human	SRI homodimer complex	human umbilical vein endothelial cells	P30626	6717	MI:0018-two hybrid;MI:0096-pull down	GO:0005515;GO:0005509	protein binding;calcium ion binding	16.01;16.17.01	protein binding;calcium binding	12804766	The penta-EF hand (PEF) family of calcium binding proteins includes grancalcin, peflin, sorcin, calpain large and small subunits as well as ALG-2. Heterodimerization, in addition to differential interactions with target proteins, might be a way to regulate and fine tune processes mediated by calcium binding proteins of the penta-EF hand type. The interaction of grancalcin with sorcin is approximately 17 times stronger than sorcin homodimerization.	None	None	Homo sapiens (Human)	Sorcin	SRI	None
5373	Chromatin remodeling complex (KAT2B, TACC2, TACC3)	Human	Chromatin remodeling complex (TACC2, TACC3, PCAF)	HEK293 cells	O95359;Q92831;Q9Y6A5	10579;8850;10460	MI:0018-two hybrid;MI:0019-coimmunoprecipitation;MI:0047-far western blotting;MI:0096-pull down	GO:0006265	DNA topological change	10.01.09.05	DNA conformation modification (e.g. chromatin)	14767476	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transforming acidic coiled-coil-containing protein 2;Histone acetyltransferase KAT2B;Transforming acidic coiled-coil-containing protein 3	TACC2;KAT2B;TACC3	None;PCAF;ERIC1
5375	EGR-EP300 complex	Human	None	prostate cancer cell line M12	P18146;Q09472	1958;2033	MI:0019-coimmunoprecipitation	GO:0006351	DNA-templated transcription	11	TRANSCRIPTION	15225550	The results show that the interactions between p300/CBPand Egr1 can lead to complex feedback loops and toinhibition of Egr1 activities under specific conditions.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Early growth response protein 1;Histone acetyltransferase p300	EGR1;EP300	KROX24, ZNF225;P300
5378	TRBP containing complex (DICER, TRBP, AGO2, RPL7A, EIF6, MOV10)	Human	None	HEK 293 cells	P56537;P62424;Q15633;Q9HCE1;Q9UKV8;Q9UPY3	3692;6130;6895;4343;27161;23405	MI:0071-molecular sieving;MI:0096-pull down	GO:0032774;GO:0006396;GO:0003723	RNA biosynthetic process;RNA processing;RNA binding	11.02;11.04;16.03.03	RNA synthesis;RNA processing;RNA binding	17507929	The authors show that depletion of eIF6 in human cells specifically abrogates miRNA-mediated regulation of target protein and mRNA levels.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Eukaryotic translation initiation factor 6;60S ribosomal protein L7a;RISC-loading complex subunit TARBP2;Helicase MOV-10;Protein argonaute-2;Endoribonuclease Dicer	EIF6;RPL7A;TARBP2;MOV10;AGO2;DICER1	EIF3A ITGB4BP;SURF-3 SURF3;TRBP;KIAA1631;EIF2C2;DICER HERNA KIAA0928
5380	TRBP containing complex (DICER, RPL7A, EIF6, MOV10 and subunits of the 60S ribosomal particle)	Human	None	HEK 293 cells	P05386;P05387;P18077;P18124;P26373;P30050;P46778;P46779;P49207;P50914;P56537;P61313;P61353;P61513;P62424;P62888;P62906;P62910;P62913;P84098;Q02543;Q9HCE1;Q9UHA3;Q9UPY3;Q9Y3U8	6176;6181;6165;6129;6137;6136;6144;6158;6164;9045;3692;6138;6155;6168;6130;6156;4736;6161;6135;6143;6142;4343;51187;23405;25873	MI:0071-molecular sieving;MI:0096-pull down	GO:0032774;GO:0006417;GO:0003723	RNA biosynthetic process;regulation of translation;RNA binding	11.02;12.07;16.03.03	RNA synthesis;translational control;RNA binding	17507929	In mass spectrometric sequencing analyses the authors showed that in addition to RISC subunits they obtained protein sequences corresponding to nearly all subunits of the large (60S) ribosomal particle. The ability of eIF6 to inhibit joining of the 60S and 40S subunits of the ribosome and, thus, to prevent formation of a translationally competent complex, raises the possibility that eIF6 may repress translation by blocking initiation or ribosome recycling.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	60S acidic ribosomal protein P1;60S acidic ribosomal protein P2;60S ribosomal protein L35a;60S ribosomal protein L7;60S ribosomal protein L13;60S ribosomal protein L12;60S ribosomal protein L21;60S ribosomal protein L28;60S ribosomal protein L34;60S ribosomal protein L14;Eukaryotic translation initiation factor 6;60S ribosomal protein L15;60S ribosomal protein L27;60S ribosomal protein L37a;60S ribosomal protein L7a;60S ribosomal protein L30;60S ribosomal protein L10a;60S ribosomal protein L32;60S ribosomal protein L11;60S ribosomal protein L19;60S ribosomal protein L18a;Helicase MOV-10;Probable ribosome biogenesis protein RLP24;Endoribonuclease Dicer;60S ribosomal protein L36	RPLP1;RPLP2;RPL35A;RPL7;RPL13;RPL12;RPL21;RPL28;RPL34;RPL14;EIF6;RPL15;RPL27;RPL37A;RPL7A;RPL30;RPL10A;RPL32;RPL11;RPL19;RPL18A;MOV10;RSL24D1;DICER1;RPL36	RRP1;D11S2243E RPP2;None;None;BBC1;None;None;None;None;None;EIF3A ITGB4BP;EC45;None;None;SURF-3 SURF3;None;NEDD6;None;None;None;None;KIAA1631;C15orf15 RPL24L;DICER HERNA KIAA0928;None
5381	RISC-loading complex	Human	AGO2-DICER1-TARBP2 complex	HEK 293 cells	Q15633;Q9UKV8;Q9UPY3	6895;27161;23405	MI:0071-molecular sieving;MI:0096-pull down	GO:0032774;GO:0006396;GO:0003723;GO:0005737	RNA biosynthetic process;RNA processing;RNA binding;cytoplasm	11.02;11.04;16.03.03;70.03	RNA synthesis;RNA processing;RNA binding;cytoplasm	16271387	The authors demonstrated that this complex can cleave target RNA using precursor microRNA (pre-miRNA) hairpin as the source of siRNA.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	RISC-loading complex subunit TARBP2;Protein argonaute-2;Endoribonuclease Dicer	TARBP2;AGO2;DICER1	TRBP;EIF2C2;DICER HERNA KIAA0928
5382	ARNT-HIF1A complex	Human	None	None	P27540;Q16665	405;3091	MI:0019-coimmunoprecipitation	GO:0045893;GO:0005634	positive regulation of DNA-templated transcription;nucleus	11.02.03.04.01;70.10	transcription activation;nucleus	8663540	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Aryl hydrocarbon receptor nuclear translocator;Hypoxia-inducible factor 1-alpha	ARNT;HIF1A	BHLHE2;BHLHE78 MOP1 PASD8
5383	TRIB3-DDIT3 complex	Human	None	None	P35638;Q96RU7	1649;57761	MI:0019-coimmunoprecipitation	GO:2001141;GO:0006355	regulation of RNA biosynthetic process;regulation of DNA-templated transcription	11.02.03.04	transcriptional control	15775988	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	DNA damage-inducible transcript 3 protein;Tribbles homolog 3	DDIT3;TRIB3	CHOP CHOP10 GADD153;C20orf97 NIPK SKIP3 TRB3
5384	RAG1-RAG2 tetramer complex	Human	None	None	P15918;P55895	5896;5897	MI:0004-affinity chromatography technology	GO:0006310	DNA recombination	10.01.05.03	DNA recombination	10373515	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	V(D)J recombination-activating protein 1;V(D)J recombination-activating protein 2	RAG1;RAG2	RNF74;None
5385	GAIT complex	Human	None	U937 cells; in vitro translation	O60506;P04406;P07814;P40429	10492;2597;2058;23521	MI:0004-affinity chromatography technology;MI:0019-coimmunoprecipitation	GO:0006417;GO:0010629	regulation of translation;negative regulation of gene expression	12.07	translational control	15479637	None	None	Human proteins are expressed in E. coli or insect cells.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Heterogeneous nuclear ribonucleoprotein Q;Glyceraldehyde-3-phosphate dehydrogenase;Bifunctional glutamate/proline--tRNA ligase;60S ribosomal protein L13a	SYNCRIP;GAPDH;EPRS1;RPL13A	HNRPQ NSAP1;GAPD;EPRS GLNS PARS QARS QPRS;None
5386	MLL1-WDR5 complex	Human	None	None	O00268;O43451;O75461;P21675;P34932;P49848;P51610;P61964;Q03164;Q15291;Q15545;Q16594;Q6PI98;Q7Z3B3;Q8IXM2;Q8IZL8;Q8WWY3;Q96EZ8;Q99496;Q9BVI0;Q9H4L4;Q9H7Z6;Q9HCK8;Q9NXF1;Q9UBL3;Q9Y265;Q9Y4W2	6874;8972;1876;6872;3308;6878;3054;11091;4297;5929;6879;6880;125476;284058;124944;27043;26121;10445;6045;51230;26168;84148;57680;54881;9070;8607;81887	MI:0007-anti tag coimmunoprecipitation;MI:0226-ion exchange chromatography	GO:0006265;GO:0045893;GO:0018126;GO:0006479;GO:0005634	DNA topological change;positive regulation of DNA-templated transcription;protein hydroxylation;protein methylation;nucleus	10.01.09.05;11.02.03.04.01;14.07.09;70.10	DNA conformation modification (e.g. chromatin);transcription activation;posttranslational modification of amino acids (e.g. hydroxylation, methylation);nucleus	15960975	The MLL1-WDR5 complex has a robust MLL1-mediated histone methyltransferase activity that can effect mono-, di-, and trimethylation of H3 K4 and a MOF-mediated histone acetyltransferase activity that is specific for H4 K16. Both activities are required for optimal transcription activation on a chromatin template in vitro and on an endogenous MLL1 target gene, Hox a9, in vivo.	The MLL1 subunit is the product of a protooncogene that was first detected through chromosomal translocations directly associated with aggressive lymphoid and myeloid acute leukemias, especially among infants.	The apparent size of the MOF-containing MLL1-WDR5 complex is around 1.5 MDa.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transcription initiation factor TFIID subunit 4;Maltase-glucoamylase;Transcription factor E2F6;Transcription initiation factor TFIID subunit 1;Heat shock 70 kDa protein 4;Transcription initiation factor TFIID subunit 6;Host cell factor 1;WD repeat-containing protein 5;Histone-lysine N-methyltransferase 2A;Retinoblastoma-binding protein 5;Transcription initiation factor TFIID subunit 7;Transcription initiation factor TFIID subunit 9;INO80 complex subunit C;KAT8 regulatory NSL complex subunit 1;Chromatin complexes subunit BAP18;Proline-, glutamic acid- and leucine-rich protein 1;U4/U6 small nuclear ribonucleoprotein Prp31;Microspherule protein 1;E3 ubiquitin-protein ligase RING2;PHD finger protein 20;Sentrin-specific protease 3;Histone acetyltransferase KAT8;Chromodomain-helicase-DNA-binding protein 8;Testis-expressed protein 10;Set1/Ash2 histone methyltransferase complex subunit ASH2;RuvB-like 1;Ribosomal biogenesis protein LAS1L	TAF4;MGAM;E2F6;TAF1;HSPA4;TAF6;HCFC1;WDR5;KMT2A;RBBP5;TAF7;TAF9;INO80C;KANSL1;BAP18;PELP1;PRPF31;MCRS1;RNF2;PHF20;SENP3;KAT8;CHD8;TEX10;ASH2L;RUVBL1;LAS1L	TAF2C TAF2C1 TAF4A TAFII130 TAFII135;MGA MGAML;None;BA2R CCG1 CCGS TAF2A;APG2;TAF2E TAFII70;HCF1, HFC1;BIG3;ALL1 CXXC7 HRX HTRX MLL MLL1 TRX1;RBQ3;TAF2F TAFII55;TAF2G TAFII31;C18orf37;CENP-36 KIAA1267 MSL1V1 NSL1;C17orf49;HMX3 MNAR;PRP31;INO80Q MSP58;BAP1 DING HIPI3 RING1B;C20orf104 GLEA2 HCA58 NZF TZP;SSP3, SUSP3;MOF MYST1;HELSNF1 KIAA1564;None;ASH2L1;INO80H NMP238 TIP49 TIP49A;None
5388	SERPINA1-ELA2 complex	Human	None	None	P01009;P08246	5265;1991	MI:0107-surface plasmon resonance	GO:0016485	protein processing	14.07.11	protein processing (proteolytic)	15131125	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Alpha-1-antitrypsin;Neutrophil elastase	SERPINA1;ELANE	AAT PI;ELA2
5389	SERPINA3-CTSG complex	Human	None	None	P01011;P08311	12;1511	MI:0107-surface plasmon resonance	GO:0016485	protein processing	14.07.11	protein processing (proteolytic)	15131125	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Alpha-1-antichymotrypsin;Cathepsin G	SERPINA3;CTSG	AACT;None
5391	SERPINA1-CTSG complex	Human	None	None	P01009;P08311	5265;1511	MI:0107-surface plasmon resonance	GO:0016485	protein processing	14.07.11	protein processing (proteolytic)	15131125	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Alpha-1-antitrypsin;Cathepsin G	SERPINA1;CTSG	AAT PI;None
5400	BRCC complex	Human	Ubiquitin E3 ligase	None	P38398;P46736;P51587;Q06609;Q9NXR7	672;79184;675;5888;9577	MI:0004-affinity chromatography technology	GO:0006281;GO:0000075;GO:0016567;GO:0006974;GO:0005634;GO:0006511	DNA repair;cell cycle checkpoint signaling;protein ubiquitination;cellular response to DNA damage stimulus;nucleus;ubiquitin-dependent protein catabolic process	10.01.05.01;10.03.01.03;14.07.05;32.01.09;70.10;14.13.01.01	DNA repair;cell cycle checkpoints (checkpoints of morphogenesis, DNA-damage,-replication, mitotic phase and spindle);modification by ubiquitination, deubiquitination;DNA damage response;nucleus;proteasomal degradation (ubiquitin/proteasomal pathway)	14636569	BRCC may not play a direct role in DNA repair, but through its E3 ubiquitin ligase activity BRCC can regulate factors involved in DNA repair. BRE and BRCC36 are regulatory subunits modulating the ligase activity of the BRCC complex.	BRCA1 or BRCA2 genes and their deleterious alleles are involved in breast cancer and ovarian cancer.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Breast cancer type 1 susceptibility protein;Lys-63-specific deubiquitinase BRCC36;Breast cancer type 2 susceptibility protein;DNA repair protein RAD51 homolog 1;BRISC and BRCA1-A complex member 2	BRCA1;BRCC3;BRCA2;RAD51;BABAM2	RNF53;BRCC36 C6.1A CXorf53;FACD FANCD1;RAD51A RECA;BRCC45 BRE
5401	PLEKHM2-KIF5B complex	Human	SKIP-kinesin complex	HeLa cells	P33176;Q8IWE5	3799;23207	MI:0096-pull down	GO:0048870	cell motility	None	None	15905402	During Salmonella typhimurium infection SKIP acts as an essential mediator of SifA (a S. thyphimurium protein, required for the formation of Salmonella-induced filaments). A dynamic process of kinesin recruitment in Salmonella-infected cells is mediated by the secretion of unidentified SPI-2 TTSS effectors and is down-regulated by the SifA-mediated recruitment of SKIP on membranes. The authors suggest that S. typhimurium is able to fine-tune the SCV-associated kinesin motor activity by regulating the secretion of its own effector proteins.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Kinesin-1 heavy chain;Pleckstrin homology domain-containing family M member 2	KIF5B;PLEKHM2	KNS, KNS1;KIAA0842 SKIP
5407	NGF-TrkA complex	Human	None	None	P01138;P04629	4803;4914	MI:0114-x-ray crystallography	GO:0007169;GO:0022008;GO:0048699;GO:0007399	transmembrane receptor protein tyrosine kinase signaling pathway;neurogenesis;generation of neurons;nervous system development	30.05.01.12;41.05.13;47.03.01	transmembrane receptor protein tyrosine kinase signalling pathways;neurogenesis;nervous system	10490030	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Beta-nerve growth factor;High affinity nerve growth factor receptor	NGF;NTRK1	NGFB;MTC TRK TRKA
5408	Neurotrophin-3-p75 complex	Human	None	None	P08138;P20783	4804;4908	MI:0114-x-ray crystallography	GO:0007169;GO:0022008;GO:0048699;GO:0007399	transmembrane receptor protein tyrosine kinase signaling pathway;neurogenesis;generation of neurons;nervous system development	30.05.01.12;41.05.13;47.03.01	transmembrane receptor protein tyrosine kinase signalling pathways;neurogenesis;nervous system	18596692	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Tumor necrosis factor receptor superfamily member 16;Neurotrophin-3	NGFR;NTF3	TNFRSF16;None
5409	TIAM1-GRIN1 complex	Human	None	None	Q05586;Q13009	2902;7074	MI:0019-coimmunoprecipitation	GO:0000902;GO:0016049;GO:0030182	cell morphogenesis;cell growth;neuron differentiation	40.01;43.03.13	cell growth / morphogenesis;neuron	15721239	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Glutamate receptor ionotropic, NMDA 1;Rho guanine nucleotide exchange factor TIAM1	GRIN1;TIAM1	NMDAR1;None
5411	HTR1D-S1PR1 complex	Human	HTR1D-EDG1 complex	None	P21453;P28221	1901;3352	MI:0019-coimmunoprecipitation	GO:0007186	G protein-coupled receptor signaling pathway	30.05.02.24	G-protein coupled receptor signalling pathway	11854302	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Sphingosine 1-phosphate receptor 1;5-hydroxytryptamine receptor 1D	S1PR1;HTR1D	CHEDG1 EDG1;HTR1DA HTRL
5412	HTR1D  homodimer complex	Human	None	None	P28221	3352	MI:0019-coimmunoprecipitation	GO:0005515	protein binding	16.01	protein binding	11854302	None	None	None	Homo sapiens (Human)	5-hydroxytryptamine receptor 1D	HTR1D	HTR1DA HTRL
5414	HTR1A-HTR1D complex	Human	None	None	P08908;P28221	3350;3352	MI:0019-coimmunoprecipitation	GO:0005515	protein binding	16.01	protein binding	11854302	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	5-hydroxytryptamine receptor 1A;5-hydroxytryptamine receptor 1D	HTR1A;HTR1D	ADRB2RL1 ADRBRL1;HTR1DA HTRL
5415	HTR1B homodimer complex	Human	None	None	P28222	3351	MI:0019-coimmunoprecipitation	GO:0005515	protein binding	16.01	protein binding	11854302	None	None	None	Homo sapiens (Human)	5-hydroxytryptamine receptor 1B	HTR1B	HTR1DB
5416	HTR1A-HTR1B complex	Human	None	None	P08908;P28222	3350;3351	MI:0019-coimmunoprecipitation	GO:0005515	protein binding	16.01	protein binding	11854302	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	5-hydroxytryptamine receptor 1A;5-hydroxytryptamine receptor 1B	HTR1A;HTR1B	ADRB2RL1 ADRBRL1;HTR1DB
5417	HTR1D-HTR1B complex	Human	None	None	P28221;P28222	3352;3351	MI:0019-coimmunoprecipitation	GO:0005515	protein binding	16.01	protein binding	11854302	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	5-hydroxytryptamine receptor 1D;5-hydroxytryptamine receptor 1B	HTR1D;HTR1B	HTR1DA HTRL;HTR1DB
5418	GABBR2-HTR1A complex	Human	None	None	O75899;P08908	9568;3350	MI:0019-coimmunoprecipitation	GO:0005515	protein binding	16.01	protein binding	11854302	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Gamma-aminobutyric acid type B receptor subunit 2;5-hydroxytryptamine receptor 1A	GABBR2;HTR1A	GPR51 GPRC3B;ADRB2RL1 ADRBRL1
5419	HTR1A-GPR26 complex	Human	None	None	P08908;Q8NDV2	3350;2849	MI:0019-coimmunoprecipitation	GO:0005515	protein binding	16.01	protein binding	11854302	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	5-hydroxytryptamine receptor 1A;G-protein coupled receptor 26	HTR1A;GPR26	ADRB2RL1 ADRBRL1;
5420	HTR1A-EDG3 complex	Human	None	None	P08908;Q99500	3350;1903	MI:0019-coimmunoprecipitation	GO:0005515	protein binding	16.01	protein binding	11854302	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	5-hydroxytryptamine receptor 1A;Sphingosine 1-phosphate receptor 3	HTR1A;S1PR3	ADRB2RL1 ADRBRL1;C9orf108 C9orf47 EDG3
5421	HTR1A homodimer complex	Human	None	None	P08908	3350	MI:0019-coimmunoprecipitation	GO:0005515	protein binding	16.01	protein binding	11854302	None	None	None	Homo sapiens (Human)	5-hydroxytryptamine receptor 1A	HTR1A	ADRB2RL1 ADRBRL1
5422	HTR1A-S1PR1 complex	Human	HTR1A-EDG1 complex	None	P08908;P21453	3350;1901	MI:0019-coimmunoprecipitation	GO:0007186	G protein-coupled receptor signaling pathway	30.05.02.24	G-protein coupled receptor signalling pathway	11854302	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	5-hydroxytryptamine receptor 1A;Sphingosine 1-phosphate receptor 1	HTR1A;S1PR1	ADRB2RL1 ADRBRL1;CHEDG1 EDG1
5423	HSP70-BAG5-PARK2 complex	Human	None	HEK 293T cells	O60260;P0DMV8;P34932;Q9UL15	5071;3303;3308;9529	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0050821;GO:0006457;GO:0030234;GO:0050790	protein stabilization;protein folding;enzyme regulator activity;regulation of catalytic activity	14.01;18.02.01	protein folding and stabilization;enzymatic activity regulation / enzyme regulator	15603737	The authors show that within this complex, BAG5 inhibits both parkin E3 ubiquitin ligase activity and Hsp70-mediated refolding of misfolded proteins.	None	Since the authors did not specify HSP70, we used isoform HSPA1A (HSP70-1A).	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase parkin;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 4;BAG family molecular chaperone regulator 5	PRKN;HSPA1A;HSPA4;BAG5	PARK2;HSP72 HSPA1 HSX70;APG2;KIAA0873
5424	NGF-p75 complex	Human	None	None	P01138;P08138	4803;4804	MI:0114-x-ray crystallography	GO:0007169;GO:0022008;GO:0048699;GO:0007399	transmembrane receptor protein tyrosine kinase signaling pathway;neurogenesis;generation of neurons;nervous system development	30.05.01.12;41.05.13;47.03.01	transmembrane receptor protein tyrosine kinase signalling pathways;neurogenesis;nervous system	15131306	The complex is composed of an NGF homodimer asymmetrically bound to a single p75.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Beta-nerve growth factor;Tumor necrosis factor receptor superfamily member 16	NGF;NGFR	NGFB;TNFRSF16
5426	ANKRD11-HDAC3  complex	Human	ANCO1-HDAC3  complex	HeLa cells; 293T cells	O15379;Q6UB99	8841;29123	MI:0018-two hybrid;MI:0019-coimmunoprecipitation;MI:0047-far western blotting;MI:0096-pull down	GO:0045892;GO:0030506	negative regulation of DNA-templated transcription;ankyrin binding	11.02.03.04.03	transcription repression	15184363	A co-immunoprecipitation assay demonstrated the formation of an ANCO-1/HDAC3 protein complex in vivo. ANCO-1 did not colocalize with the nuclear HDAC1 or the cytoplasmic HDAC6.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Histone deacetylase 3;Ankyrin repeat domain-containing protein 11	HDAC3;ANKRD11	None;ANCO1
5432	Sororin-cohesin complex	Human	None	None	O60216;Q14683;Q29RF7;Q96FF9;Q9NTI5;Q9UQE7	5885;8243;23244;113130;23047;9126	MI:0004-affinity chromatography technology;MI:0007-anti tag coimmunoprecipitation	GO:0000278;GO:0007059;GO:0005634	mitotic cell cycle;chromosome segregation;nucleus	10.03.01.01;10.03.04.05;70.10	mitotic cell cycle;chromosome segregation/division;nucleus	15837422	Sororin interacts with the cohesin complex. It regulates the ability of the cohesin complex to mediate sister chromatid cohesion.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Double-strand-break repair protein rad21 homolog;Structural maintenance of chromosomes protein 1A;Sister chromatid cohesion protein PDS5 homolog A;Sororin;Sister chromatid cohesion protein PDS5 homolog B;Structural maintenance of chromosomes protein 3	RAD21;SMC1A;PDS5A;CDCA5;PDS5B;SMC3	HR21 KIAA0078 NXP1 SCC1;DXS423E KIAA0178 SB1.8 SMC1 SMC1L1;KIAA0648 PDS5;None;APRIN AS3 KIAA0979;BAM BMH CSPG6 SMC3L1
5441	NRG1-IKZF4 complex	Human	None	None	Q02297;Q9H2S9	3084;64375	MI:0019-coimmunoprecipitation	GO:2001141;GO:0006355	regulation of RNA biosynthetic process;regulation of DNA-templated transcription	11.02.03.04	transcriptional control	15494726	The Nrg-ICD-Eos complex induces endogenous PSD-95 expression in vivo through a signaling pathway that is mostly independent of gamma-secretase regulation. This upregulation of PSD-95 expression by the Nrg-ICD-Eos complex provides a molecular basis for activity-dependent synaptic plasticity.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Pro-neuregulin-1, membrane-bound isoform;Zinc finger protein Eos	NRG1;IKZF4	GGF HGL HRGA NDF SMDF;KIAA1782 ZNFN1A4
5442	EPOR receptor complex	Human	None	None	P19235	2057	MI:0114-x-ray crystallography	GO:0005515	protein binding	16.01	protein binding	8662530	None	None	None	Homo sapiens (Human)	Erythropoietin receptor	EPOR	None
5446	EPO-EPOR complex	Human	None	None	P01588;P19235	2056;2057	MI:0114-x-ray crystallography	GO:0023052	signaling	30.01	cellular signalling	9774108	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Erythropoietin;Erythropoietin receptor	EPO;EPOR	None;None
5449	Splicing-associated factors complex (ALYREF, DEK, RBM8A, RNPS1, SRRM1)	Human	None	HeLa cells	P35659;Q15287;Q86V81;Q8IYB3;Q9Y5S9	7913;10921;10189;10250;9939	MI:0019-coimmunoprecipitation	GO:0005681	spliceosomal complex	None	None	11118221	Possible functions for this complex in nucleocytoplasmic transport of spliced mRNA, as well as the nonsense-mediated mRNA decay pathway, are discussed.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein DEK;RNA-binding protein with serine-rich domain 1;THO complex subunit 4;Serine/arginine repetitive matrix protein 1;RNA-binding protein 8A	DEK;RNPS1;ALYREF;SRRM1;RBM8A	None;LDC2;ALY BEF THOC4;SRM160;RBM8
5450	Mediator complex	Human	None	None	A0JLT2;O43513;O60244;O60313;O75448;O75586;O95402;Q13503;Q15528;Q15648;Q6P2C8;Q71F56;Q71SY5;Q96G25;Q96HR3;Q96RN5;Q9BTT4;Q9BUE0;Q9H944;Q9NPJ6;Q9NVC6;Q9NX70;Q9P086;Q9UHV7;Q9ULK4;Q9Y2X0;Q9Y3C7	219541;9443;9282;4976;9862;10001;9441;9412;6837;5469;9442;23389;81857;112950;90390;51586;84246;54797;9477;29079;9440;55588;400569;9969;9439;10025;51003	MI:0004-affinity chromatography technology	GO:0045893;GO:0005515;GO:0051090;GO:0005634	positive regulation of DNA-templated transcription;protein binding;regulation of DNA-binding transcription factor activity;nucleus	11.02.03.04.01;16.01;18.02.09;70.10	transcription activation;protein binding;regulator of transcription factor;nucleus	14576168	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mediator of RNA polymerase II transcription subunit 19;Mediator of RNA polymerase II transcription subunit 7;Mediator of RNA polymerase II transcription subunit 14;Dynamin-like 120 kDa protein, mitochondrial;Mediator of RNA polymerase II transcription subunit 24;Mediator of RNA polymerase II transcription subunit 6;Mediator of RNA polymerase II transcription subunit 26;Mediator of RNA polymerase II transcription subunit 21;Mediator of RNA polymerase II transcription subunit 22;Mediator of RNA polymerase II transcription subunit 1;Mediator of RNA polymerase II transcription subunit 27;Mediator of RNA polymerase II transcription subunit 13-like;Mediator of RNA polymerase II transcription subunit 25;Mediator of RNA polymerase II transcription subunit 8;Mediator of RNA polymerase II transcription subunit 30;Mediator of RNA polymerase II transcription subunit 15;Mediator of RNA polymerase II transcription subunit 10;Mediator of RNA polymerase II transcription subunit 18;Mediator of RNA polymerase II transcription subunit 20;Mediator of RNA polymerase II transcription subunit 4;Mediator of RNA polymerase II transcription subunit 17;Mediator of RNA polymerase II transcription subunit 29;Mediator of RNA polymerase II transcription subunit 11;Mediator of RNA polymerase II transcription subunit 13;Mediator of RNA polymerase II transcription subunit 23;Mediator of RNA polymerase II transcription subunit 16;Mediator of RNA polymerase II transcription subunit 31	MED19;MED7;MED14;OPA1;MED24;MED6;MED26;MED21;MED22;MED1;MED27;MED13L;MED25;MED8;MED30;MED15;MED10;MED18;MED20;MED4;MED17;MED29;MED11;MED13;MED23;MED16;MED31	LCMR1;ARC34 CRSP9;ARC150 CRSP2 CXorf4 DRIP150 EXLM1 RGR1 TRAP170;KIAA0567;ARC100 CRSP4 DRIP100 KIAA0130 THRAP4 TRAP100;ARC33;ARC70 CRSP7;SRB7 SURB7;SURF5;ARC205 CRSP1 CRSP200 DRIP205 DRIP230 PBP PPARBP PPARGBP RB18A TRAP220 TRIP2;CRSP34 CRSP8;KIAA1025 PROSIT240 THRAP2 TRAP240L;ACID1 ARC92 PTOV2;None;THRAP6 TRAP25;ARC105 CTG7A PCQAP TIG1 TNRC7;None;None;TRFP;ARC36 DRIP36 VDRIP;ARC77 CRSP6 DRIP77 DRIP80 TRAP80;IXL;None;ARC250 KIAA0593 THRAP1 TRAP240;ARC130 CRSP3 DRIP130 KIAA1216 SUR2;DRIP92 THRAP5;SOH1
5451	MED18-MED20-MED29 mediator subcomplex	Human	None	None	Q9BUE0;Q9H944;Q9NX70	54797;9477;55588	MI:0004-affinity chromatography technology	GO:0045893;GO:0005515;GO:0051090;GO:0005634	positive regulation of DNA-templated transcription;protein binding;regulation of DNA-binding transcription factor activity;nucleus	11.02.03.04.01;16.01;18.02.09;70.10	transcription activation;protein binding;regulator of transcription factor;nucleus	14576168	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mediator of RNA polymerase II transcription subunit 18;Mediator of RNA polymerase II transcription subunit 20;Mediator of RNA polymerase II transcription subunit 29	MED18;MED20;MED29	None;TRFP;IXL
5460	NF(kappa)B p50-p65 complex	Human	None	in vitro	P19838;Q04206	4790;5970	MI:0018-two hybrid	GO:0045893;GO:0035525;GO:0001819;GO:0051607;GO:0006954;GO:0045087;GO:0019048	positive regulation of DNA-templated transcription;NF-kappaB p50/p65 complex;positive regulation of cytokine production;defense response to virus;inflammatory response;innate immune response;modulation by virus of host process	11.02.03.04.01;36.25.16.07;36.25.16.01	transcription activation;inflammatory response;innate immune response (invertebrates and vertebrates)	9556555	Measles virus V protein interacts with the p65 (RelA) subunit of the NF(kappa)B p50-p65 complex to suppress NF-kappaB activity (PMID:21270162).	None	None	Homo sapiens (Human);Homo sapiens (Human)	Nuclear factor NF-kappa-B p105 subunit;Transcription factor p65	NFKB1;RELA	None;NFKB3
5465	IKB(epsilon)-RELA-cREL complex	Human	None	Jurkat cells	O00221;Q04206;Q04864	4794;5970;5966	MI:0006-anti bait coimmunoprecipitation	GO:2001141;GO:0006355;GO:0007249;GO:0005737	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;I-kappaB kinase/NF-kappaB signaling;cytoplasm	11.02.03.04;30.01.05.01.04;70.03	transcriptional control;NIK-I-kappaB/NF-kappaB cascade;cytoplasm	9135156	IKB(epsilon) is able to inhibit NF(kappa)B-directed transactivation via cytoplasmic retention of rel proteins.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	NF-kappa-B inhibitor epsilon;Transcription factor p65;Proto-oncogene c-Rel	NFKBIE;RELA;REL	IKBE;NFKB3;None
5466	IKB(beta)-RELA-cREL complex	Human	None	Jurkat cells	Q04206;Q04864;Q15653	5970;5966;4793	MI:0006-anti bait coimmunoprecipitation	GO:2001141;GO:0006355;GO:0007249;GO:0005737	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;I-kappaB kinase/NF-kappaB signaling;cytoplasm	11.02.03.04;30.01.05.01.04;70.03	transcriptional control;NIK-I-kappaB/NF-kappaB cascade;cytoplasm	9135156	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transcription factor p65;Proto-oncogene c-Rel;NF-kappa-B inhibitor beta	RELA;REL;NFKBIB	NFKB3;None;IKBB TRIP9
5467	IKB(alpha)-RELA-cREL complex	Human	None	Jurkat cells	P25963;Q04206;Q04864	4792;5970;5966	MI:0006-anti bait coimmunoprecipitation	GO:2001141;GO:0006355;GO:0007249;GO:0023052;GO:0005737	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;I-kappaB kinase/NF-kappaB signaling;signaling;cytoplasm	11.02.03.04;30.01.05.01.04;30.01;70.03	transcriptional control;NIK-I-kappaB/NF-kappaB cascade;cellular signalling;cytoplasm	9135156	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	NF-kappa-B inhibitor alpha;Transcription factor p65;Proto-oncogene c-Rel	NFKBIA;RELA;REL	IKBA MAD3 NFKBI;NFKB3;None
5473	DISC complex (FAS, FADD, CASP8)	Human	Death-inducing signaling complex (DISC)	None	P25445;Q13158;Q14790	355;8772;841	MI:0019-coimmunoprecipitation	GO:0006915;GO:0097191	apoptotic process;extrinsic apoptotic signaling pathway	40.10.02	apoptosis (type I programmed cell death)	15383280	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Tumor necrosis factor receptor superfamily member 6;FAS-associated death domain protein;Caspase-8	FAS;FADD;CASP8	APT1 FAS1 TNFRSF6;MORT1;MCH5
5475	MURR1-NF(kappa)Bp65-IKBA complex	Human	None	None	P25963;Q04206;Q8N668	4792;5970;150684	MI:0006-anti bait coimmunoprecipitation	GO:0007249	I-kappaB kinase/NF-kappaB signaling	30.01.05.01.04	NIK-I-kappaB/NF-kappaB cascade	14685242	Murr1, a gene product known previously for its involvement in copper regulation, inhibits HIV-1 growth in unstimulated CD4+ T cells. This inhibition was mediated in part through its ability to inhibit basal and cytokine-stimulated nuclear factor NF(kappa)B activity.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	NF-kappa-B inhibitor alpha;Transcription factor p65;COMM domain-containing protein 1	NFKBIA;RELA;COMMD1	IKBA MAD3 NFKBI;NFKB3;C2orf5, MURR1
5492	NF(kappa)B p50-p65-IKBA complex	Human	NFKB1-NFKBIA-RELA complex; I(kappa)B(alpha)-NF(kappa)Bp65-NF(kappa)Bp50 complex;	HEK293 cells	P19838;P25963;Q04206	4790;4792;5970	MI:0019-coimmunoprecipitation	GO:0007249;GO:0005737;GO:0045892	I-kappaB kinase/NF-kappaB signaling;cytoplasm;negative regulation of DNA-templated transcription	30.01.05.01.04;70.03;11.02.03.04.03	NIK-I-kappaB/NF-kappaB cascade;cytoplasm;transcription repression	12972430	IkappaB alpha binds the NF-kappaB p50/p65 heterodimer with 60- and 27-fold higher affinity than the p50 and p65 homodimers, respectively and inhibits DNA binding activity of NF(kappa)B heterodimer. (PMID:12972430)	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Nuclear factor NF-kappa-B p105 subunit;NF-kappa-B inhibitor alpha;Transcription factor p65	NFKB1;NFKBIA;RELA	None;IKBA MAD3 NFKBI;NFKB3
5495	CIA targeting (MIP18, CIAO1, MMS19) complex	Human	FAM96B-CIAO1-MMS19 complex	HeLa cells; HEK293T cells	O76071;Q96T76;Q9Y3D0	9391;64210;51647	MI:0019-coimmunoprecipitation	GO:0016226	iron-sulfur cluster assembly	None	None	28178521	The cytoplasmic iron-sulfur assembly (CIA) targeting complex is required for the transfer of an iron-sulfur (Fe-S) cluster to cytoplasmic and nuclear proteins. The complex members MIP18 and CIAO1 associate with the C terminus of MMS19. By doing so, they form a docking site for Fe-S proteins that is disrupted in the absence of either MMS19 or MIP18. The Fe-S helicase XPD seems to be the only exception, since it can interact with MMS19 independently of MIP18 and CIAO1. The direct interaction between MMS19 and MIP18 is required to protect MIP18 from proteasomal degradation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Probable cytosolic iron-sulfur protein assembly protein CIAO1;MMS19 nucleotide excision repair protein homolog;Cytosolic iron-sulfur assembly component 2B	CIAO1;MMS19;CIAO2B	CIA1 WDR39;MMS19L;CIAB FAM96B MIP18
5498	ILK-PARVB-ARHGEF6 complex	Human	None	HEK 293 cells	Q13418;Q15052;Q9HBI1	3611;9459;29780	MI:0007-anti tag coimmunoprecipitation	GO:0007264;GO:0030036	small GTPase mediated signal transduction;actin cytoskeleton organization	30.01.05.05.01;42.04.03	small GTPase mediated signal transduction;actin cytoskeleton	15897874	The results suggest that activation of alpha-PIX is dependent on ILK binding to beta-parvin, an event that depends upon ILK activity.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin-linked protein kinase;Rho guanine nucleotide exchange factor 6;Beta-parvin	ILK;ARHGEF6;PARVB	ILK1 ILK2;COOL2 KIAA0006 PIXA;None
5499	PARVB-ARHGEF6 complex	Human	None	HEK 293 cells	Q15052;Q9HBI1	9459;29780	MI:0007-anti tag coimmunoprecipitation	GO:0030036	actin cytoskeleton organization	42.04.03	actin cytoskeleton	15897874	The complex between beta-parvin and alpha-PIX is constitutively formed and is not regulated by either the presence or absence of ILK or its kinase activity. This suggests that ILK may modulate the activity of alpha-PIX indirectly through its binding to and phosphorylation of beta-parvin.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Rho guanine nucleotide exchange factor 6;Beta-parvin	ARHGEF6;PARVB	COOL2 KIAA0006 PIXA;None
5502	EED-EZH-YY1 polycomb complex	Human	None	None	O75530;P25490;Q15910	8726;7528;2146	MI:0006-anti bait coimmunoprecipitation	GO:0045892;GO:0032774;GO:0003677;GO:0005634	negative regulation of DNA-templated transcription;RNA biosynthetic process;DNA binding;nucleus	11.02.03.04.03;11.02;16.03.01;70.10	transcription repression;RNA synthesis;DNA binding;nucleus	11158321	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Polycomb protein EED;Transcriptional repressor protein YY1;Histone-lysine N-methyltransferase EZH2	EED;YY1;EZH2	None;INO80S;KMT6
5513	RING1-Polycomb repressive complex	Human	hPc2-RING1-BMI1-HPH1 complex	SW480 cells	O00257;P35226;P78364;Q06587	8535;648;1911;6015	MI:0006-anti bait coimmunoprecipitation	GO:0045892;GO:0005634	negative regulation of DNA-templated transcription;nucleus	11.02.03.04.03;70.10	transcription repression;nucleus	9199346	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 SUMO-protein ligase CBX4;Polycomb complex protein BMI-1;Polyhomeotic-like protein 1;E3 ubiquitin-protein ligase RING1	CBX4;BMI1;PHC1;RING1	None;PCGF4 RNF51;EDR1 PH1;RNF1
5518	BMI1-HPH1-HPH2 complex	Human	None	U2OS cells	P35226;P78364;Q8IXK0	648;1911;1912	MI:0006-anti bait coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0045892;GO:0032774;GO:0003677;GO:0005634	negative regulation of DNA-templated transcription;RNA biosynthetic process;DNA binding;nucleus	11.02.03.04.03;11.02;16.03.01;70.10	transcription repression;RNA synthesis;DNA binding;nucleus	9121482	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Polycomb complex protein BMI-1;Polyhomeotic-like protein 1;Polyhomeotic-like protein 2	BMI1;PHC1;PHC2	PCGF4 RNF51;EDR1 PH1;EDR2 PH2
5521	EED-EZH polycomb complex	Human	None	U2OS cells	O75530;Q15910	8726;2146	MI:0006-anti bait coimmunoprecipitation;MI:0018-two hybrid	GO:0045892;GO:0032774;GO:0003677;GO:0005634	negative regulation of DNA-templated transcription;RNA biosynthetic process;DNA binding;nucleus	11.02.03.04.03;11.02;16.03.01;70.10	transcription repression;RNA synthesis;DNA binding;nucleus	9584199	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Polycomb protein EED;Histone-lysine N-methyltransferase EZH2	EED;EZH2	None;KMT6
5526	BCL2 -CALM1-FKBP38 complex	Human	None	human SH-SY5Y neuroblastoma cells	P0DP23;P10415;Q14318	801;596;23770	MI:0019-coimmunoprecipitation;MI:0047-far western blotting	GO:0005509;GO:0030234;GO:0050790;GO:0043067;GO:0006915	calcium ion binding;enzyme regulator activity;regulation of catalytic activity;regulation of programmed cell death;apoptotic process	16.17.01;18.02.01;40.10.02.04;40.10.02	calcium binding;enzymatic activity regulation / enzyme regulator;regulation of apoptosis;apoptosis (type I programmed cell death)	15990872	Association between Bcl-2 and the active site of Ca2+/calmodulin/FKBP38 regulates Bcl-2 function and thereby participates in the promotion of apoptosis in neuronal tissues.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Calmodulin-1;Apoptosis regulator Bcl-2;Peptidyl-prolyl cis-trans isomerase FKBP8	CALM1;BCL2;FKBP8	CALM CAM CAM1;None;FKBP38
5529	BIRC2-TRAF2 complex	Human	TRAF2-cIAP1 complex	Jurkat cells; 293 cells; transfected Cos7 cells; HeLa cells	Q12933;Q13490	7186;329	MI:0019-coimmunoprecipitation;MI:0047-far western blotting;MI:0663-confocal microscopy	GO:0016567;GO:0006915;GO:0005783	protein ubiquitination;apoptotic process;endoplasmic reticulum	14.07.05;40.10.02;70.07	modification by ubiquitination, deubiquitination;apoptosis (type I programmed cell death);endoplasmic reticulum	15861135	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	TNF receptor-associated factor 2;Baculoviral IAP repeat-containing protein 2	TRAF2;BIRC2	TRAP3;API1 MIHB RNF48
5530	LTBR homodimer complex	Human	None	HepG2 cells; HeLa cells	P36941-1	4055	MI:0018-two hybrid;MI:0047-far western blotting;MI:0096-pull down	GO:0023052	signaling	30.01	cellular signalling	9371602	The viral HCV (hepatitis) core protein can associate with the dimeric or oligomeric form of LT-bR, and this protein-protein interaction has a modulatory effect on the signaling pathway of LT-bR in certain cell types.	None	LTBR (435 aa) is a splice variant/isoform.	Homo sapiens (Human)	Isoform 1 of Tumor necrosis factor receptor superfamily member 3	LTBR	D12S370 TNFCR TNFR3 TNFRSF3
5531	TNFR1-TRADD-TRAF2-cIAP1 complex	Human	TNFR1 signaling sub-complex	human U937 histiocytic lymphoma cells; HeLa cells	P19438;Q12933;Q13490;Q15628	7132;7186;329;8717	MI:0019-coimmunoprecipitation;MI:0047-far western blotting	GO:0023052;GO:0006915	signaling;apoptotic process	30.01;40.10.02	cellular signalling;apoptosis (type I programmed cell death)	8943045	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Tumor necrosis factor receptor superfamily member 1A;TNF receptor-associated factor 2;Baculoviral IAP repeat-containing protein 2;Tumor necrosis factor receptor type 1-associated DEATH domain protein	TNFRSF1A;TRAF2;BIRC2;TRADD	TNFAR, TNFR1;TRAP3;API1 MIHB RNF48;None
5534	PLCB1-PARD3-PARD6A complex	Human	None	HEK 293T cells	Q8TEW0;Q9NPB6;Q9NQ66	56288;50855;23236	MI:0019-coimmunoprecipitation	GO:2001141;GO:0006355;GO:0023052;GO:0019932;GO:0051211;GO:0009798	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;signaling;second-messenger-mediated signaling;anisotropic cell growth;axis specification	11.02.03.04;30.01;30.01.09;40.01.03;41.05.19	transcriptional control;cellular signalling;second messenger mediated signal transduction;directional cell growth (morphogenesis);asymmetries and axis determination	15782111	The results suggest that the interaction of PLC-beta with cell polarity Par proteins may serve as a nexus to transduce extracellular signals to transcriptional regulation through G-protein-mediated signaling pathway in cell polarity and cell asymmetric division.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Partitioning defective 3 homolog;Partitioning defective 6 homolog alpha;1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	PARD3;PARD6A;PLCB1	PAR3 PAR3A;PAR6A;KIAA0581
5535	PLCB3-PARD3-PARD6A complex	Human	None	HEK 293T cells	Q01970;Q8TEW0;Q9NPB6	5331;56288;50855	MI:0019-coimmunoprecipitation	GO:2001141;GO:0006355;GO:0023052;GO:0019932;GO:0051211;GO:0009798	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;signaling;second-messenger-mediated signaling;anisotropic cell growth;axis specification	11.02.03.04;30.01;30.01.09;40.01.03;41.05.19	transcriptional control;cellular signalling;second messenger mediated signal transduction;directional cell growth (morphogenesis);asymmetries and axis determination	15782111	The results suggest that the interaction of PLC-beta with cell polarity Par proteins may serve as a nexus to transduce extracellular signals to transcriptional regulation through G-protein-mediated signaling pathway in cell polarity and cell asymmetric division.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3;Partitioning defective 3 homolog;Partitioning defective 6 homolog alpha	PLCB3;PARD3;PARD6A	None;PAR3 PAR3A;PAR6A
5540	TRAF2-TRADD complex	Human	None	HEK 293T cells	Q12933;Q15628	7186;8717	MI:0019-coimmunoprecipitation	GO:0006915	apoptotic process	40.10.02	apoptosis (type I programmed cell death)	12796506	TRADD and TRAF2 form a ternary complex  with the viral protein NS5A.	None	None	Homo sapiens (Human);Homo sapiens (Human)	TNF receptor-associated factor 2;Tumor necrosis factor receptor type 1-associated DEATH domain protein	TRAF2;TRADD	TRAP3;None
5541	FADD-TRADD-TRAF2 complex	Human	None	293T cells	Q12933;Q13158;Q15628	7186;8772;8717	MI:0004-affinity chromatography technology;MI:0047-far western blotting;MI:0413-electrophoretic mobility shift assay	GO:0006915	apoptotic process	40.10.02	apoptosis (type I programmed cell death)	12796506	The nonstructural 5A (NS5A) protein of hepatitis C virus (HCV) is a phosphoprotein possessing various functions. It is here suggested that HCV NS5A may in part modulate TNFR1-associated signaling pathways during viral infection.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	TNF receptor-associated factor 2;FAS-associated death domain protein;Tumor necrosis factor receptor type 1-associated DEATH domain protein	TRAF2;FADD;TRADD	TRAP3;MORT1;None
5542	CCNB2-CDC2 complex	Human	None	HeLa cells; human proteins expressed in COS-7 cells	O95067;P06493	9133;983	MI:0019-coimmunoprecipitation;MI:0416-fluorescence microscopy	GO:0007049;GO:0005737	cell cycle;cytoplasm	10.03;70.03	cell cycle;cytoplasm	8070405	Cyclin-CDK complexes are involved in the regulation of many of the important transitions of the cell cycle, such as the decisions to enter mitosis and to begin DNA replication.	None	Although the cytoplasmic retention signal region is outside the cyclin box, its sequence is well conserved in human cyclin B2, and is both necessary and sufficient to keep cyclin B2 in the cytoplasm.	Homo sapiens (Human);Homo sapiens (Human)	G2/mitotic-specific cyclin-B2;Cyclin-dependent kinase 1	CCNB2;CDK1	None;CDC2 CDC28A CDKN1 P34CDC2
5543	CCNB1-CDK1 complex	Human	CCNB1-CDC2 complex	HeLa cells; human proteins expressed in COS-7 cells	P06493;P14635	983;891	MI:0019-coimmunoprecipitation;MI:0416-fluorescence microscopy	GO:0007049;GO:0005737	cell cycle;cytoplasm	10.03;70.03	cell cycle;cytoplasm	8070405	Cyclin-CDK complexes are involved in the regulation of many of the important transitions of the cell cycle, such as the decisions to enter mitosis and to begin DNA replication.	None	The cytoplasmic localization of cyclin B1 does not depend on its ability to bind a CDK subunit. The cytoplasmic retention signal region of cyclinB1 is necessary for cytoplasmic localization.	Homo sapiens (Human);Homo sapiens (Human)	Cyclin-dependent kinase 1;G2/mitotic-specific cyclin-B1	CDK1;CCNB1	CDC2 CDC28A CDKN1 P34CDC2;CCNB
5544	CCNB1-CDK1-GADD45A-PCNA complex	Human	CDC2-PCNA-CCNB1-GADD45A complex	H1299 cells; RKO cells	P06493;P12004;P14635;P24522	983;5111;891;1647	MI:0019-coimmunoprecipitation;MI:0047-far western blotting;MI:0096-pull down	GO:0007049	cell cycle	10.03	cell cycle	12124778	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cyclin-dependent kinase 1;Proliferating cell nuclear antigen;G2/mitotic-specific cyclin-B1;Growth arrest and DNA damage-inducible protein GADD45 alpha	CDK1;PCNA;CCNB1;GADD45A	CDC2 CDC28A CDKN1 P34CDC2;None;CCNB;DDIT1 GADD45
5545	CCNB1-CDK1-GADD45B-PCNA complex	Human	CCNB1-CDC2-GADD45B-PCNA complex	H1299 cells; RKO cells	O75293;P06493;P12004;P14635	4616;983;5111;891	MI:0019-coimmunoprecipitation;MI:0047-far western blotting;MI:0096-pull down	GO:0007049	cell cycle	10.03	cell cycle	12124778	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Growth arrest and DNA damage-inducible protein GADD45 beta;Cyclin-dependent kinase 1;Proliferating cell nuclear antigen;G2/mitotic-specific cyclin-B1	GADD45B;CDK1;PCNA;CCNB1	MYD118;CDC2 CDC28A CDKN1 P34CDC2;None;CCNB
5546	CCNB1-CDK1-GADD45G-PCNA complex	Human	CDC2-PCNA-CCNB1-GADD45G complex	H1299 cells; RKO cells	O95257;P06493;P12004;P14635	10912;983;5111;891	MI:0019-coimmunoprecipitation;MI:0047-far western blotting;MI:0096-pull down	GO:0007049	cell cycle	10.03	cell cycle	12124778	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Growth arrest and DNA damage-inducible protein GADD45 gamma;Cyclin-dependent kinase 1;Proliferating cell nuclear antigen;G2/mitotic-specific cyclin-B1	GADD45G;CDK1;PCNA;CCNB1	CR6 DDIT2;CDC2 CDC28A CDKN1 P34CDC2;None;CCNB
5549	Interleukin-12B homodimer	Human	IL-12 subunit p40 homodimer complex	COS cells	P29460	3593	MI:0019-coimmunoprecipitation;MI:0071-molecular sieving	GO:0030217;GO:0035722;GO:0019221;GO:0006955	T cell differentiation;interleukin-12-mediated signaling pathway;cytokine-mediated signaling pathway;immune response	43.03.07.02.01.02;36.25.16	T-cell;immune response	7527811	The authors demonstrated that when p40 (IL12B) is associated with a p35 (IL12A) subunit, the heterodimer acts as an agonist mediating biologic activity, and when p40 associates with another p40, the homodimer behaves as an antagonist in vitro.	None	None	Homo sapiens (Human)	Interleukin-12 subunit beta	IL12B	NKSF2
5550	CDK1-CCNB1-CCNF complex	Human	CDC2-CCNB1-CCNF complex	HeLa cells; transfected 293T cells	P06493;P14635;P41002	983;891;899	MI:0019-coimmunoprecipitation	GO:0007049	cell cycle	10.03	cell cycle	10716937	Cdc2, cyclin B1 and cyclin F form  a complex that exhibits histone  H1 kinase activity.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cyclin-dependent kinase 1;G2/mitotic-specific cyclin-B1;Cyclin-F	CDK1;CCNB1;CCNF	CDC2 CDC28A CDKN1 P34CDC2;CCNB;FBX1 FBXO1
5551	CCNB1-CDK1-PTCH1 complex	Human	CDC2-CCNB1-PTCH1 complex	293T cells; human proteins expressed in COS-1 cells	P06493;P14635;Q13635	983;891;5727	MI:0019-coimmunoprecipitation;MI:0051-fluorescence technology	GO:0007049	cell cycle	10.03	cell cycle	11331587	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cyclin-dependent kinase 1;G2/mitotic-specific cyclin-B1;Protein patched homolog 1	CDK1;CCNB1;PTCH1	CDC2 CDC28A CDKN1 P34CDC2;CCNB;PTCH
5556	CCNA2 -CDK2 complex	Human	None	HeLa cells	P20248;P24941	890;1017	MI:0019-coimmunoprecipitation	GO:0007049	cell cycle	10.03	cell cycle	8475101	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cyclin-A2;Cyclin-dependent kinase 2	CCNA2;CDK2	CCN1 CCNA;CDKN2
5557	CCNA2-CDK1 complex	Human	None	in vitro; human ML1 (myeloid leukemia) cells	P06493;P20248	983;890	MI:0019-coimmunoprecipitation	GO:0007049	cell cycle	10.03	cell cycle	8423786	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cyclin-dependent kinase 1;Cyclin-A2	CDK1;CCNA2	CDC2 CDC28A CDKN1 P34CDC2;CCN1 CCNA
5558	PAR6-CDC42 complex	Human	None	None	P60953;Q9BYG5	998;84612	MI:0114-x-ray crystallography	None	None	None	None	12606577	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cell division control protein 42 homolog;Partitioning defective 6 homolog beta	CDC42;PARD6B	None;PAR6B
5560	CCNE1-CDK2 complex	Human	None	human fibroblasts	P24864;P24941	898;1017	MI:0019-coimmunoprecipitation	GO:0007049;GO:0000082	cell cycle;G1/S transition of mitotic cell cycle	10.03;10.03.01.01.03	cell cycle;G1/S transition of mitotic cell cycle	8560263	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	G1/S-specific cyclin-E1;Cyclin-dependent kinase 2	CCNE1;CDK2	CCNE;CDKN2
5564	LMO4-gp130 complex	Human	None	HepG2 cells	O14543;P23458;P40189;P61968;Q06124	9021;3716;3572;8543;5781	MI:0007-anti tag coimmunoprecipitation	GO:0045893;GO:0023052	positive regulation of DNA-templated transcription;signaling	11.02.03.04.01;30.01	transcription activation;cellular signalling	15677447	LMO4 associates with the gp130 complex and IL-6 may enhance its association.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Suppressor of cytokine signaling 3;Tyrosine-protein kinase JAK1;Interleukin-6 receptor subunit beta;LIM domain transcription factor LMO4;Tyrosine-protein phosphatase non-receptor type 11	SOCS3;JAK1;IL6ST;LMO4;PTPN11	CIS3 SSI3;JAK1A JAK1B;None;None;PTP2C SHPTP2
5573	Stat1-alpha-dimer-CBP DNA-protein complex	Human	None	None	P42224;Q92793	6772;1387	MI:0096-pull down;MI:0413-electrophoretic mobility shift assay	GO:2001141;GO:0006355;GO:0005634	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;nucleus	11.02.03.04;70.10	transcriptional control;nucleus	8986769	The results demonstrate that both phosphorylated homodimeric and unphosphorylated monomeric Stat1-alpha can interact with CBP/p300, and their interactions occur at two different regions of both Stat1-alpha and CBP/p300.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Signal transducer and activator of transcription 1-alpha/beta;CREB-binding protein	STAT1;CREBBP	None;CBP
5575	SHP-NR5A2 complex	Human	None	None	O00482;Q15466	2494;8431	MI:0018-two hybrid;MI:0096-pull down	GO:0045892	negative regulation of DNA-templated transcription	11.02.03.04.03	transcription repression	11030331	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Nuclear receptor subfamily 5 group A member 2;Nuclear receptor subfamily 0 group B member 2	NR5A2;NR0B2	B1F CPF FTF;SHP
5579	CNTF-CNTFR-gp130-LIFR complex	Human	None	EW-1 cells	P26441;P26992;P40189;P42702	1270;1271;3572;3977	MI:0030-cross-linking study	GO:0023052;GO:0007399	signaling;nervous system development	30.01;47.03.01	cellular signalling;nervous system	8385113	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Ciliary neurotrophic factor;Ciliary neurotrophic factor receptor subunit alpha;Interleukin-6 receptor subunit beta;Leukemia inhibitory factor receptor	CNTF;CNTFR;IL6ST;LIFR	None;None;None;None
5582	LIFR-LIF-gp130 complex	Human	None	COS cells	P15018;P40189;P42702	3976;3572;3977	MI:0030-cross-linking study	GO:0023052;GO:0007399	signaling;nervous system development	30.01;47.03.01	cellular signalling;nervous system	8385113	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Leukemia inhibitory factor;Interleukin-6 receptor subunit beta;Leukemia inhibitory factor receptor	LIF;IL6ST;LIFR	HILDA;None;None
5589	LINC complex, S-phase	Human	None	T98G cells	P10244;P28749;Q09028;Q52LA3;Q5TKA1;Q6MZP7;Q96GY3	4605;5933;5928;91750;286826;132660;55957	MI:0006-anti bait coimmunoprecipitation	GO:0000086;GO:0045893;GO:0005634	G2/M transition of mitotic cell cycle;positive regulation of DNA-templated transcription;nucleus	10.03.01.01.09;11.02.03.04.01;70.10	G2/M transition of mitotic cell cycle;transcription activation;nucleus	17671431	During S-phase B-MYB and p107 become incorporated into the LINC complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Myb-related protein B;Retinoblastoma-like protein 1;Histone-binding protein RBBP4;Protein lin-52 homolog;Protein lin-9 homolog;Protein lin-54 homolog;Protein lin-37 homolog	MYBL2;RBL1;RBBP4;LIN52;LIN9;LIN54;LIN37	BMYB;None;RBAP48;C14orf46;BARA TGS;CXCDC1 KIAA2037;None
5593	LINC core complex	Human	None	MOLT-4 cells	Q09028;Q52LA3;Q5TKA1;Q6MZP7;Q96GY3	5928;91750;286826;132660;55957	MI:0007-anti tag coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0000086;GO:0045893;GO:0005634	G2/M transition of mitotic cell cycle;positive regulation of DNA-templated transcription;nucleus	10.03.01.01.09;11.02.03.04.01;70.10	G2/M transition of mitotic cell cycle;transcription activation;nucleus	17671431	LINC selectively binds to the promoters of G2/M genes whose products are required for mitosis and plays an important role in their cell cycle dependent activation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone-binding protein RBBP4;Protein lin-52 homolog;Protein lin-9 homolog;Protein lin-54 homolog;Protein lin-37 homolog	RBBP4;LIN52;LIN9;LIN54;LIN37	RBAP48;C14orf46;BARA TGS;CXCDC1 KIAA2037;None
5596	LINC complex, quiescent cells	Human	None	T98G cells	Q08999;Q09028;Q16254;Q52LA3;Q5TKA1;Q6MZP7;Q96GY3	5934;5928;1874;91750;286826;132660;55957	MI:0006-anti bait coimmunoprecipitation	GO:0000086;GO:0045893;GO:0005634	G2/M transition of mitotic cell cycle;positive regulation of DNA-templated transcription;nucleus	10.03.01.01.09;11.02.03.04.01;70.10	G2/M transition of mitotic cell cycle;transcription activation;nucleus	17671431	In quiescent cells LINC selectively interacts with p130 and E2F4. This association is lost during S-phase.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Retinoblastoma-like protein 2;Histone-binding protein RBBP4;Transcription factor E2F4;Protein lin-52 homolog;Protein lin-9 homolog;Protein lin-54 homolog;Protein lin-37 homolog	RBL2;RBBP4;E2F4;LIN52;LIN9;LIN54;LIN37	RB2;RBAP48;None;C14orf46;BARA TGS;CXCDC1 KIAA2037;None
5604	Emerin complex 1	Human	None	None	P35579;P50402;P60709;Q12965;Q13813;Q15417;Q8WWI1;Q9BRV8	4627;2010;60;4643;6709;1266;4008;80143	MI:0004-affinity chromatography technology	GO:0005634	nucleus	70.10	nucleus	17620012	None	Emerin is involved in Emery-Dreifuss muscular dystrophy (EDMD).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Myosin-9;Emerin;Actin, cytoplasmic 1;Unconventional myosin-Ie;Spectrin alpha chain, non-erythrocytic 1;Calponin-3;LIM domain only protein 7;Suppressor of IKBKE 1	MYH9;EMD;ACTB;MYO1E;SPTAN1;CNN3;LMO7;SIKE1	None;EDMD STA;None;MYO1C;NEAS SPTA2;None;FBX20 FBXO20 KIAA0858;SIKE
5606	Emerin-actin-NMI-(alphaII)spectrin complex	Human	None	None	P50402;P60709;Q13287;Q13813	2010;60;9111;6709	MI:0004-affinity chromatography technology;MI:0071-molecular sieving;MI:0226-ion exchange chromatography	GO:0005634	nucleus	70.10	nucleus	17620012	None	Emerin is involved in Emery-Dreifuss muscular dystrophy (EDMD).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Emerin;Actin, cytoplasmic 1;N-myc-interactor;Spectrin alpha chain, non-erythrocytic 1	EMD;ACTB;NMI;SPTAN1	EDMD STA;None;None;NEAS SPTA2
5607	Emerin-actin-NMI complex	Human	None	None	P50402;P60709;Q13287	2010;60;9111	MI:0004-affinity chromatography technology;MI:0071-molecular sieving;MI:0226-ion exchange chromatography	GO:0005634	nucleus	70.10	nucleus	17620012	None	Emerin is involved in Emery-Dreifuss muscular dystrophy (EDMD).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Emerin;Actin, cytoplasmic 1;N-myc-interactor	EMD;ACTB;NMI	EDMD STA;None;None
5608	Emerin architectural complex	Human	None	None	P02545;P20700;P50402;P60709;Q13287;Q13813	4000;4001;2010;60;9111;6709	MI:0004-affinity chromatography technology;MI:0071-molecular sieving;MI:0226-ion exchange chromatography	GO:0006997;GO:0005634	nucleus organization;nucleus	42.10;70.10	nucleus;nucleus	17620012	None	Emerin is involved in Emery-Dreifuss muscular dystrophy (EDMD).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Prelamin-A/C;Lamin-B1;Emerin;Actin, cytoplasmic 1;N-myc-interactor;Spectrin alpha chain, non-erythrocytic 1	LMNA;LMNB1;EMD;ACTB;NMI;SPTAN1	LMN1;LMN2 LMNB;EDMD STA;None;None;NEAS SPTA2
5609	Emerin regulatory complex	Human	None	None	O15379;O75531;P28749;P50402;P60709;P68431;Q02539;Q13547;Q8WWI1	8841;8815;5933;2010;60;None;3024;3065;4008	MI:0004-affinity chromatography technology;MI:0071-molecular sieving;MI:0226-ion exchange chromatography	GO:0006265;GO:2001141;GO:0006355;GO:0051276;GO:0005634	DNA topological change;regulation of RNA biosynthetic process;regulation of DNA-templated transcription;chromosome organization;nucleus	10.01.09.05;11.02.03.04;42.10.03;70.10	DNA conformation modification (e.g. chromatin);transcriptional control;organization of chromosome structure;nucleus	17620012	None	Emerin is involved in Emery-Dreifuss muscular dystrophy (EDMD).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone deacetylase 3;Barrier-to-autointegration factor;Retinoblastoma-like protein 1;Emerin;Actin, cytoplasmic 1;Histone H3.1;Histone H1.1;Histone deacetylase 1;LIM domain only protein 7	HDAC3;BANF1;RBL1;EMD;ACTB;H3C1;H1-1;HDAC1;LMO7	None;BAF BCRG1;None;EDMD STA;None;H3FA,HIST1H3A;H1F1 HIST1H1A;RPD3L1;FBX20 FBXO20 KIAA0858
5611	Emerin complex 24	Human	None	None	P02545;P06400;P20700;P33991;P49736;P50402;P68431;Q00839;Q02539;Q07021;Q08999;Q13287;Q14566;Q9H0E3;Q9H503	4000;5925;4001;4173;4171;2010;None;3192;3024;708;5934;9111;4175;79595;140836	MI:0004-affinity chromatography technology;MI:0071-molecular sieving;MI:0226-ion exchange chromatography	GO:0006260;GO:0006396;GO:0005634	DNA replication;RNA processing;nucleus	10.01.03;11.04;70.10	DNA synthesis and replication;RNA processing;nucleus	17620012	Complexes are named on the basis of their S300 elution fraction number. Subunits 9-15 were identified via LCMS/MS analysis.	Emerin is involved in Emery-Dreifuss muscular dystrophy (EDMD).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Prelamin-A/C;Retinoblastoma-associated protein;Lamin-B1;DNA replication licensing factor MCM4;DNA replication licensing factor MCM2;Emerin;Histone H3.1;Heterogeneous nuclear ribonucleoprotein U;Histone H1.1;Complement component 1 Q subcomponent-binding protein, mitochondrial;Retinoblastoma-like protein 2;N-myc-interactor;DNA replication licensing factor MCM6;Histone deacetylase complex subunit SAP130;Barrier-to-autointegration factor-like protein	LMNA;RB1;LMNB1;MCM4;MCM2;EMD;H3C1;HNRNPU;H1-1;C1QBP;RBL2;NMI;MCM6;SAP130;BANF2	LMN1;None;LMN2 LMNB;CDC21;BM28 CCNL1 CDCL1 KIAA0030;EDMD STA;H3FA,HIST1H3A;C1orf199 HNRPU SAFA U21.1;H1F1 HIST1H1A;GC1QBP HABP1 SF2P32;RB2;None;None;None;BAFL C20orf179
5613	Emerin complex 25	Human	None	None	O75531;O95218;O95777;P05455;P20700;P31946;P50402;P60709;P61978;P62258;P62314;Q13283;Q16543;Q9H0E3;Q9P287;Q9Y333	8815;9406;51691;6741;4001;7529;2010;60;3190;7531;6632;10146;11140;79595;56647;57819	MI:0004-affinity chromatography technology;MI:0071-molecular sieving;MI:0226-ion exchange chromatography	GO:0006396;GO:0035556;GO:0005634	RNA processing;intracellular signal transduction;nucleus	11.04;30.01;70.10	RNA processing;cellular signalling;nucleus	17620012	Complexes are named on the basis of their S300 elution fraction number. Subunits 5-16 were identified via LCMS/MS analysis.	Emerin is involved in Emery-Dreifuss muscular dystrophy (EDMD).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Barrier-to-autointegration factor;Zinc finger Ran-binding domain-containing protein 2;U6 snRNA-associated Sm-like protein LSm8;Lupus La protein;Lamin-B1;14-3-3 protein beta/alpha;Emerin;Actin, cytoplasmic 1;Heterogeneous nuclear ribonucleoprotein K;14-3-3 protein epsilon;Small nuclear ribonucleoprotein Sm D1;Ras GTPase-activating protein-binding protein 1;Hsp90 co-chaperone Cdc37;Histone deacetylase complex subunit SAP130;BRCA2 and CDKN1A-interacting protein;U6 snRNA-associated Sm-like protein LSm2	BANF1;ZRANB2;LSM8;SSB;LMNB1;YWHAB;EMD;ACTB;HNRNPK;YWHAE;SNRPD1;G3BP1;CDC37;SAP130;BCCIP;LSM2	BAF BCRG1;ZIS ZNF265;None;None;LMN2 LMNB;None;EDMD STA;None;HNRPK;None;None;G3BP;CDC37A;None;TOK1;C6orf28 G7B
5614	Emerin complex 32	Human	None	None	O00422;O15379;P20700;P28749;P50402;P60709;P68431;Q08999;Q12824;Q13263;Q13287;Q13547;Q13813;Q14839;Q8TAQ2;Q92922;Q9BQ87;Q9BZK7;Q9C005;Q9H503;Q9NPJ6;Q9UKL0	10284;8841;4001;5933;2010;60;None;5934;6598;10155;9111;3065;6709;1108;6601;6599;90665;79718;84661;140836;29079;23186	MI:0004-affinity chromatography technology;MI:0071-molecular sieving;MI:0226-ion exchange chromatography	GO:0006265;GO:0051276;GO:0005634	DNA topological change;chromosome organization;nucleus	10.01.09.05;42.10.03;70.10	DNA conformation modification (e.g. chromatin);organization of chromosome structure;nucleus	17620012	Complexes are named on the basis of their S300 elution fraction number. Subunits 9-22 were identified via LCMS/MS analysis.	Emerin is involved in Emery-Dreifuss muscular dystrophy (EDMD).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone deacetylase complex subunit SAP18;Histone deacetylase 3;Lamin-B1;Retinoblastoma-like protein 1;Emerin;Actin, cytoplasmic 1;Histone H3.1;Retinoblastoma-like protein 2;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1;Transcription intermediary factor 1-beta;N-myc-interactor;Histone deacetylase 1;Spectrin alpha chain, non-erythrocytic 1;Chromodomain-helicase-DNA-binding protein 4;SWI/SNF complex subunit SMARCC2;SWI/SNF complex subunit SMARCC1;F-box-like/WD repeat-containing protein TBL1Y;F-box-like/WD repeat-containing protein TBL1XR1;Protein dpy-30 homolog;Barrier-to-autointegration factor-like protein;Mediator of RNA polymerase II transcription subunit 4;REST corepressor 1	SAP18;HDAC3;LMNB1;RBL1;EMD;ACTB;H3C1;RBL2;SMARCB1;TRIM28;NMI;HDAC1;SPTAN1;CHD4;SMARCC2;SMARCC1;TBL1Y;TBL1XR1;DPY30;BANF2;MED4;RCOR1	None;None;LMN2 LMNB;None;EDMD STA;None;H3FA,HIST1H3A;RB2;BAF47, INI1, SNF5L1;KAP1 RNF96 TIF1B;None;RPD3L1;NEAS SPTA2;None;BAF170;BAF155;TBL1;IRA1 TBLR1;None;BAFL C20orf179;ARC36 DRIP36 VDRIP;KIAA0071 RCOR
5615	Emerin complex 52	Human	None	None	O00148;O95777;P10827;P12277;P14866;P20700;P27348;P46940;P50402;P51858;P60709;P61978;P62258;P62314;Q00839;Q02539;Q07021;Q08999;Q12906;Q13287;Q53EL6;Q9BZZ5;Q9Y2U8	10212;51691;7067;1152;3191;4001;10971;8826;2010;3068;60;3190;7531;6632;3192;3024;708;5934;3609;9111;27250;8539;23592	MI:0004-affinity chromatography technology;MI:0071-molecular sieving;MI:0226-ion exchange chromatography	GO:0006396;GO:0035556;GO:0005634	RNA processing;intracellular signal transduction;nucleus	11.04;30.01;70.10	RNA processing;cellular signalling;nucleus	17620012	Complexes are named on the basis of their S300 elution fraction number. Subunits 8-23 were identified via LCMS/MS analysis.	Emerin is involved in Emery-Dreifuss muscular dystrophy (EDMD).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	ATP-dependent RNA helicase DDX39A;U6 snRNA-associated Sm-like protein LSm8;Thyroid hormone receptor alpha;Creatine kinase B-type;Heterogeneous nuclear ribonucleoprotein L;Lamin-B1;14-3-3 protein theta;Ras GTPase-activating-like protein IQGAP1;Emerin;Hepatoma-derived growth factor;Actin, cytoplasmic 1;Heterogeneous nuclear ribonucleoprotein K;14-3-3 protein epsilon;Small nuclear ribonucleoprotein Sm D1;Heterogeneous nuclear ribonucleoprotein U;Histone H1.1;Complement component 1 Q subcomponent-binding protein, mitochondrial;Retinoblastoma-like protein 2;Interleukin enhancer-binding factor 3;N-myc-interactor;Programmed cell death protein 4;Apoptosis inhibitor 5;Inner nuclear membrane protein Man1	DDX39A;LSM8;THRA;CKB;HNRNPL;LMNB1;YWHAQ;IQGAP1;EMD;HDGF;ACTB;HNRNPK;YWHAE;SNRPD1;HNRNPU;H1-1;C1QBP;RBL2;ILF3;NMI;PDCD4;API5;LEMD3	DDX39;None;EAR7 ERBA1 NR1A1 THRA1 THRA2;CKBB;HNRPL;LMN2 LMNB;None;KIAA0051;EDMD STA;HMG1L2;None;HNRPK;None;None;C1orf199 HNRPU SAFA U21.1;H1F1 HIST1H1A;GC1QBP HABP1 SF2P32;RB2;DRBF MPHOSPH4 NF90;None;H731;None;MAN1
5622	HSP90-CIP1-FKBPL complex	Human	None	U2OS cells	P07900;P38936;Q9UIM3	3320;1026;63943	MI:0006-anti bait coimmunoprecipitation;MI:0071-molecular sieving;MI:0071-molecular sieving	GO:0050821;GO:0006457;GO:0006974	protein stabilization;protein folding;cellular response to DNA damage stimulus	14.01;32.01.09	protein folding and stabilization;DNA damage response	15664193	The results show that the ability of WISp39 to stabilize p21 is dependent on its ability to bind and recruit Hsp90.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Heat shock protein HSP 90-alpha;Cyclin-dependent kinase inhibitor 1;FK506-binding protein-like	HSP90AA1;CDKN1A;FKBPL	HSP90A HSPC1 HSPCA;CAP20 CDKN1 CIP1 MDA6 PIC1 SDI1 WAF1;DIR1 NG7
5641	PSD95-FYN-NR2A complex	Human	None	HEK 293T cells	P06241;P78352;Q12879	2534;1742;2903	MI:0006-anti bait coimmunoprecipitation	GO:0023052;GO:0005886	signaling;plasma membrane	30.01;70.02	cellular signalling;eukaryotic plasma membrane / membrane attached	9892651	NR2A was coimmunoprecipitated with Fyn only in the presence of PSD-95. So it was shown that PSD-95 induced formation of a ternary complex of NR2A, PSD-95, and Fyn.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Tyrosine-protein kinase Fyn;Disks large homolog 4;Glutamate receptor ionotropic, NMDA 2A	FYN;DLG4;GRIN2A	None;PSD95;NMDAR2A
5642	Securin-separase complex	Human	None	None	O95997;Q14674	9232;9700	MI:0027-cosedimentation;MI:0071-molecular sieving	GO:0000280;GO:0007059	nuclear division;chromosome segregation	10.03.04.07;10.03.04.05	nuclear division;chromosome segregation/division	15880121	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Securin;Separin	PTTG1;ESPL1	EAP1 PTTG TUTR1;ESP1 KIAA0165
5643	ESPL1-CDC2 complex	Human	None	None	P06493;Q14674	983;9700	MI:0019-coimmunoprecipitation	GO:0000280;GO:0007059	nuclear division;chromosome segregation	10.03.04.07;10.03.04.05	nuclear division;chromosome segregation/division	15989971	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cyclin-dependent kinase 1;Separin	CDK1;ESPL1	CDC2 CDC28A CDKN1 P34CDC2;ESP1 KIAA0165
5646	FARP2-NRP1-PlexinA1 complex	Human	None	HEK 293 cells	O14786;O94887;Q9UIW2	8829;9855;5361	MI:0019-coimmunoprecipitation	GO:0023052;GO:0007399	signaling;nervous system development	30.01;47.03.01	cellular signalling;nervous system	16286926	Interaction of FARP2 with PlexinA1 is substantially reduced in the absence of neuropilin1.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Neuropilin-1;FERM, ARHGEF and pleckstrin domain-containing protein 2;Plexin-A1	NRP1;FARP2;PLXNA1	NRP, VEGF165R;KIAA0793 PLEKHC3;NOV PLXN1
5647	FARP2-NRP1-PlexinA2 complex	Human	None	HEK 293 cells	O14786;O75051;O94887	8829;5362;9855	MI:0019-coimmunoprecipitation	GO:0023052;GO:0007399	signaling;nervous system development	30.01;47.03.01	cellular signalling;nervous system	16286926	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Neuropilin-1;Plexin-A2;FERM, ARHGEF and pleckstrin domain-containing protein 2	NRP1;PLXNA2;FARP2	NRP, VEGF165R;KIAA0463 OCT PLXN2;KIAA0793 PLEKHC3
5648	FARP2-NRP1-PlexinA3 complex	Human	None	HEK 293 cells	O14786;O94887;P51805	8829;9855;55558	MI:0019-coimmunoprecipitation	GO:0023052;GO:0007399	signaling;nervous system development	30.01;47.03.01	cellular signalling;nervous system	16286926	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Neuropilin-1;FERM, ARHGEF and pleckstrin domain-containing protein 2;Plexin-A3	NRP1;FARP2;PLXNA3	NRP, VEGF165R;KIAA0793 PLEKHC3;PLXN4 SEX
5649	FARP2-NRP1-PlexinA4 complex	Human	None	HEK 293 cells	O14786;O94887;Q9HCM2	8829;9855;91584	MI:0019-coimmunoprecipitation	GO:0023052;GO:0007399	signaling;nervous system development	30.01;47.03.01	cellular signalling;nervous system	16286926	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Neuropilin-1;FERM, ARHGEF and pleckstrin domain-containing protein 2;Plexin-A4	NRP1;FARP2;PLXNA4	NRP, VEGF165R;KIAA0793 PLEKHC3;KIAA1550 PLXNA4A PLXNA4B
5654	SEMA4A-PlexinD1 complex	Human	None	None	Q9H3S1;Q9Y4D7	64218;23129	MI:0030-cross-linking study	GO:0001525;GO:0001568;GO:0001944	angiogenesis;blood vessel development;vasculature development	41.05.16;47.03.03.02	angiogenesis;vessels	17318185	SEMA4A-PlexinD1 signaling negatively regulates angiogenesis.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Semaphorin-4A;Plexin-D1	SEMA4A;PLXND1	SEMAB SEMB;KIAA0620
5655	Ternary complex (ACTN4, CAMK2A, LRRC7)	Human	None	in vitro	O43707;Q96NW7;Q9UQM7	81;57554;815	MI:0019-coimmunoprecipitation;MI:0047-far western blotting;MI:0397-two hybrid array	GO:0007155;GO:0099560	cell adhesion;synaptic membrane adhesion	34.07	cell adhesion	11160423	None	None	proteins expressed from a human brain cDNA library	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Alpha-actinin-4;Leucine-rich repeat-containing protein 7;Calcium/calmodulin-dependent protein kinase type II subunit alpha	ACTN4;LRRC7;CAMK2A	None;KIAA1365 LAP1;CAMKA KIAA0968
5656	CEBPE-E2F1-RB1 complex	Human	None	NB4 cells; U937 myeloid cells	P06400;Q01094;Q15744	5925;1869;1053	MI:0019-coimmunoprecipitation;MI:0047-far western blotting;MI:0096-pull down;MI:0276-blue native page	GO:0030851	granulocyte differentiation	43.03.07.02.02	granulocyte	12947005	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Retinoblastoma-associated protein;Transcription factor E2F1;CCAAT/enhancer-binding protein epsilon	RB1;E2F1;CEBPE	None;RBBP3;None
5658	Nrp1-PlexinD1 complex	Human	None	HEK 293T cells	O14786;Q9Y4D7	8829;23129	MI:0007-anti tag coimmunoprecipitation	GO:0001525;GO:0048738;GO:0007507;GO:0001568;GO:0001944	angiogenesis;cardiac muscle tissue development;heart development;blood vessel development;vasculature development	41.05.16;45.03.12.03;47.03.03.02	angiogenesis;heart muscle;vessels	15239958	PlexinD1-Npn1 form a functional receptor for Sema3C.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Neuropilin-1;Plexin-D1	NRP1;PLXND1	NRP, VEGF165R;KIAA0620
5659	SEMA3C-PlexinD1-Nrp1 complex	Human	None	None	O14786;Q99985;Q9Y4D7	8829;10512;23129	MI:0428-imaging technique	GO:0001525;GO:0048738;GO:0007507;GO:0001568;GO:0001944	angiogenesis;cardiac muscle tissue development;heart development;blood vessel development;vasculature development	41.05.16;45.03.12.03;47.03.03.02	angiogenesis;heart muscle;vessels	15239958	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Neuropilin-1;Semaphorin-3C;Plexin-D1	NRP1;SEMA3C;PLXND1	NRP, VEGF165R;SEMAE;KIAA0620
5660	PlexinC1-SEMA7A complex	Human	None	COS cells	O60486;O75326	10154;8482	MI:0428-imaging technique	GO:0023052;GO:0031175	signaling;neuron projection development	30.01	cellular signalling	10520995	None	None	Human is used as reference organism.	Homo sapiens (Human);Homo sapiens (Human)	Plexin-C1;Semaphorin-7A	PLXNC1;SEMA7A	VESPR;CD108 SEMAL
5661	PlexinC1-SEMA7A complex	Human	None	COS cells	O43157;Q92854	5364;10507	MI:0428-imaging technique	GO:0023052;GO:0031175	signaling;neuron projection development	30.01	cellular signalling	10520995	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Plexin-B1;Semaphorin-4D	PLXNB1;SEMA4D	KIAA0407 PLXN5 SEP;C9orf164 CD100 SEMAJ
5663	TRIM27-RB1 complex	Human	None	U2OS osteosarcoma cells	P06400;P14373	5925;5987	MI:0018-two hybrid;MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:2001141;GO:0006355;GO:0051726	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;regulation of cell cycle	11.02.03.04;10.03.01	transcriptional control;mitotic cell cycle and cell cycle control	15837424	RFP binds to Rb, in vitro and in cells, and prevents the degradation of the EID-1 inhibitor of histone acetylation and differentiation. The results provide independent support for a model whereby RFP silences Rb's prodifferentiation activity while leaving intact its ability to regulate E2F-dependent gene transcription and through this cell cycle progression.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Retinoblastoma-associated protein;Zinc finger protein RFP	RB1;TRIM27	None;RFP RNF76
5669	PlexinA3-Nrp1 complex	Human	None	COS cells	O14786;P51805	8829;55558	MI:0007-anti tag coimmunoprecipitation	GO:0007399;GO:0031175	nervous system development;neuron projection development	47.03.01	nervous system	10520995	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Neuropilin-1;Plexin-A3	NRP1;PLXNA3	NRP, VEGF165R;PLXN4 SEX
5670	PlexinB1-Nrp1 complex	Human	None	COS cells	O14786;O43157	8829;5364	MI:0007-anti tag coimmunoprecipitation	GO:0007399	nervous system development	47.03.01	nervous system	10520995	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Neuropilin-1;Plexin-B1	NRP1;PLXNB1	NRP, VEGF165R;KIAA0407 PLXN5 SEP
5673	PlexinA1-Nrp2 complex	Human	None	COS cells	O60462;Q9UIW2	8828;5361	MI:0007-anti tag coimmunoprecipitation	GO:0007399;GO:0031175	nervous system development;neuron projection development	47.03.01	nervous system	10520995	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Neuropilin-2;Plexin-A1	NRP2;PLXNA1	VEGF165R2;NOV PLXN1
5683	RAD51-RAD51D-XRCC3 complex	Human	None	in vitro	O43543;O75771;Q06609	7516;5892;5888	MI:0007-anti tag coimmunoprecipitation;MI:0047-far western blotting	GO:0006281;GO:0032508;GO:0000150;GO:0032993;GO:0008094;GO:0005524	DNA repair;DNA duplex unwinding;DNA strand exchange activity;protein-DNA complex;ATP-dependent activity, acting on DNA;ATP binding	10.01.05.01;16.19.03	DNA repair;ATP binding	15123651	XRCC2 stimulates RAD51 ATP processing and increases RAD51-mediated DNA unwinding and strand exchange activities that are integral for homologous recombination repair (HRR). RAD51 seems to be essential for HRR in both mitotic and meiotic cells. A strong adenosine nucleotide-regulated interaction between the hXRCC2-hRAD51D heterodimer and hRAD51 is detailed.	None	human proteins expressed in insect cells	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA repair protein XRCC2;DNA repair protein RAD51 homolog 4;DNA repair protein RAD51 homolog 1	XRCC2;RAD51D;RAD51	None;RAD51L3;RAD51A RECA
5685	Membrane protein complex (DERL1, NPLOC4, UFD1L, VCP, VIMP)	Human	None	HeLa cells; HEK293 cells; COS cells	P55072;Q8TAT6;Q92890;Q9BQE4;Q9BUN8	7415;55666;7353;55829;79139	MI:0019-coimmunoprecipitation;MI:0047-far western blotting;MI:0416-fluorescence microscopy	GO:0030970	retrograde protein transport, ER to cytosol	None	None	15215856	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transitional endoplasmic reticulum ATPase;Nuclear protein localization protein 4 homolog;Ubiquitin recognition factor in ER-associated degradation protein 1;Selenoprotein S;Derlin-1	VCP;NPLOC4;UFD1;SELENOS;DERL1	None;KIAA1499 NPL4;UFD1L;SELS VIMP;DER1
5689	SEMA6D-PlexinA1-NRP1 complex	Human	None	HEK 293 cells	O14786;Q8NFY4;Q9UIW2	8829;80031;5361	MI:0428-imaging technique	GO:0048738;GO:0007507;GO:0007399;GO:0003143	cardiac muscle tissue development;heart development;nervous system development;embryonic heart tube morphogenesis	45.03.12.03;47.03.01	heart muscle;nervous system	14977921	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Neuropilin-1;Semaphorin-6D;Plexin-A1	NRP1;SEMA6D;PLXNA1	NRP, VEGF165R;KIAA1479;NOV PLXN1
5691	TALL1 homo-oligomer complex	Human	None	None	Q9Y275	10673	MI:0071-molecular sieving;MI:0114-x-ray crystallography	GO:0030183	B cell differentiation	43.03.07.02.01.01	B-cell	14749821	None	None	None	Homo sapiens (Human)	Tumor necrosis factor ligand superfamily member 13B	TNFSF13B	BAFF BLYS TALL1 TNFSF20 ZTNF4
5693	BAZ2A-DNMT1-DNMT3B-HDAC1-SMARCA5 complex	Human	TIP5-DNMT-HDAC1 complex	HEK293T cells	O60264;P26358;Q13547;Q9UBC3;Q9UIF9	8467;1786;3065;1789;11176	MI:0019-coimmunoprecipitation;MI:0047-far western blotting	GO:0003677;GO:0016575;GO:0032259	DNA binding;histone deacetylation;methylation	16.03.01	DNA binding	16085498	The PHD finger/bromodomain of TIP5 interacts with HDAC1, DNMT1, DNMT3b, and SNF2h and triggers histone deacetylation and rDNA methylation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5;DNA;Histone deacetylase 1;DNA;Bromodomain adjacent to zinc finger domain protein 2A	SMARCA5;DNMT1;HDAC1;DNMT3B;BAZ2A	SNF2H, WCRF135;AIM CXXC9 DNMT;RPD3L1;None;KIAA0314 TIP5
5696	NRP2-VEGF145 complex	Human	None	umbilical vein-derived endothelial cells	O60462;P15692-6	8828;7422	MI:0030-cross-linking study	GO:0001525	angiogenesis	41.05.16	angiogenesis	10748121	None	None	VEGF145 is a splice variant of VEGFA.	Homo sapiens (Human);Homo sapiens (Human)	Neuropilin-2;Isoform VEGF145 of Vascular endothelial growth factor A	NRP2;VEGFA	VEGF165R2;VEGF
5698	FLT1-VEGF-A165b complex	Human	VEGF-A165b-VEGFR1 complex	HEK293 Cells	P15692-8;P17948	7422;2321	MI:0019-coimmunoprecipitation	GO:0001525;GO:0045603;GO:1904399;GO:0008201	angiogenesis;positive regulation of endothelial cell differentiation;heparan sulfate binding;heparin binding	41.05.16	angiogenesis	27974423	VEGF165b modulates VEGFR1 and a novel VEGFR1-STAT3 signaling pathway that promotes angiogenesis and perfusion recovery in PAD (peripheral arterial disease) (PMID:27974423).Endothelial cell mitogenic potencies of VEGF110 and VEGF121 were decreased more than 100-fold compared to that of VEGF165 (PMID:8631822). All VEGF-A isoforms (VEGF121, VEGF145, VEGF165, VEGF189, VEGF206) except VEGF121 also bind to heparan sulfate or to heparin, a highly sulfated form of heparan sulfate . Heparin augments the interaction of VEGF165 with VEGFR2 and binds to VEGFR1 (PMID:20974861).	None	VEGF-A165b is a splice variant of VEGFA.	Homo sapiens (Human);Homo sapiens (Human)	Isoform VEGF165B of Vascular endothelial growth factor A;Vascular endothelial growth factor receptor 1	VEGFA;FLT1	VEGF;FLT FRT VEGFR1
5701	NRP1-VEGF-A165/121 complex	Human	None	None	O14786;P15692-4	8829;7422	MI:0107-surface plasmon resonance	GO:0001525;GO:0001568;GO:0001944	angiogenesis;blood vessel development;vasculature development	41.05.16;47.03.03.02	angiogenesis;vessels	17575273	In contrast to former publications (PMID:10991952), both isoforms of VEGFA, VEGF(165) and VEGF(121), bind to NRP1, but only VEGF165 is sufficient to promote complex formation between VEGFR2 and NRP1.	None	VEGF-A165 is a splice variant of VEGFA.	Homo sapiens (Human);Homo sapiens (Human)	Neuropilin-1;Isoform VEGF165 of Vascular endothelial growth factor A	NRP1;VEGFA	NRP, VEGF165R;VEGF
5709	CBL-PTK2B-SORBS2 complex	Human	ArgBP2a-CBL-PTK2B complex	293T cells	O94875;P22681;Q14289	8470;867;2185	MI:0019-coimmunoprecipitation;MI:0047-far western blotting;MI:0096-pull down	GO:0006886;GO:0006605;GO:0015031;GO:0030036;GO:0030182	intracellular protein transport;protein targeting;protein transport;actin cytoskeleton organization;neuron differentiation	14.04;20.01.10;42.04.03;43.03.13	protein targeting, sorting and translocation;protein transport;actin cytoskeleton;neuron	15128873	ArgBP2, via its three SH3 domains, is able to simultaneously associate with proline-rich motifs in both Pyk2 and Cbl, and thereby function as a bridge between the latter proteins.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Sorbin and SH3 domain-containing protein 2;E3 ubiquitin-protein ligase CBL;Protein-tyrosine kinase 2-beta	SORBS2;CBL;PTK2B	ARGBP2 KIAA0777;CBL2 RNF55;FAK2 PYK2 RAFTK
5710	PRMT2 homo-oligomer complex	Human	None	None	P55345	3275	MI:0096-pull down	GO:0030545	signaling receptor regulator activity	18.02.07	regulator of receptor activity	12039952	None	None	Oligomer	Homo sapiens (Human)	Protein arginine N-methyltransferase 2	PRMT2	HMT1 HRMT1L1
5712	FAK-beta5 integrin complex, VEGF induced	Human	None	brain	P18084;Q05397	3693;5747	MI:0006-anti bait coimmunoprecipitation	GO:0007169;GO:0001525;GO:0007044;GO:0035924	transmembrane receptor protein tyrosine kinase signaling pathway;angiogenesis;cell-substrate junction assembly;cellular response to vascular endothelial growth factor stimulus	30.05.01.12;41.05.16;42.06.03	transmembrane receptor protein tyrosine kinase signalling pathways;angiogenesis;cell-substrate adherens junction	12844492	VEGF induces the formation of FAK-beta5 integrin complex.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-5;Focal adhesion kinase 1	ITGB5;PTK2	None;FAK, FAK1
5713	CBL-OSTF1-SRC complex	Human	SH3P2-CBL-SRC complex	HeLa cells; HEK293T cells	P12931;P22681;Q92882	6714;867;26578	MI:0019-coimmunoprecipitation;MI:0047-far western blotting	GO:0007155;GO:0015629	cell adhesion;actin cytoskeleton	34.07;70.04.03	cell adhesion;actin cytoskeleton	15135048	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Proto-oncogene tyrosine-protein kinase Src;E3 ubiquitin-protein ligase CBL;Osteoclast-stimulating factor 1	SRC;CBL;OSTF1	SRC1;CBL2 RNF55;None
5714	NOS3-CAV1 complex	Human	eNOS-CAV1 complex	None	P29474;Q03135	4846;857	MI:0006-anti bait coimmunoprecipitation	GO:0006808;GO:0051171;GO:0007263	regulation of nitrogen utilization;regulation of nitrogen compound metabolic process;nitric oxide mediated signal transduction	01.02.07.01;30.01.09.01	regulation of nitrogen metabolism;NO mediated signal transduction	11425855	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Nitric oxide synthase, endothelial;Caveolin-1	NOS3;CAV1	None;CAV
5716	NOS3-HSP90 complex, VEGF induced	Human	None	None	P07900;P29474	3320;4846	MI:0006-anti bait coimmunoprecipitation	GO:0006809;GO:0006808;GO:0051171;GO:0007263;GO:0007169;GO:0001525;GO:0035924	nitric oxide biosynthetic process;regulation of nitrogen utilization;regulation of nitrogen compound metabolic process;nitric oxide mediated signal transduction;transmembrane receptor protein tyrosine kinase signaling pathway;angiogenesis;cellular response to vascular endothelial growth factor stimulus	01.02.02.07;01.02.07.01;30.01.09.01;30.05.01.12;41.05.16	nitric oxide biosynthesis;regulation of nitrogen metabolism;NO mediated signal transduction;transmembrane receptor protein tyrosine kinase signalling pathways;angiogenesis	11425855	VEGF stimulation promotes dissociation of eNOS and Caveolin and association of eNOS with HSP90.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Heat shock protein HSP 90-alpha;Nitric oxide synthase, endothelial	HSP90AA1;NOS3	HSP90A HSPC1 HSPCA;None
5718	NOS3-HSP90-AKT complex, VEGF induced	Human	None	None	P07900;P29474;P31749	3320;4846;207	MI:0006-anti bait coimmunoprecipitation	GO:0006809;GO:0006808;GO:0051171;GO:0007263;GO:0007169;GO:0001525;GO:0035924	nitric oxide biosynthetic process;regulation of nitrogen utilization;regulation of nitrogen compound metabolic process;nitric oxide mediated signal transduction;transmembrane receptor protein tyrosine kinase signaling pathway;angiogenesis;cellular response to vascular endothelial growth factor stimulus	01.02.02.07;01.02.07.01;30.01.09.01;30.05.01.12;41.05.16	nitric oxide biosynthesis;regulation of nitrogen metabolism;NO mediated signal transduction;transmembrane receptor protein tyrosine kinase signalling pathways;angiogenesis	11425855	VEGF stimulation promotes association of eNOS with HSP90 and AKT.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Heat shock protein HSP 90-alpha;Nitric oxide synthase, endothelial;RAC-alpha serine/threonine-protein kinase	HSP90AA1;NOS3;AKT1	HSP90A HSPC1 HSPCA;None;PKB RAC
5720	CIN85-CBL complex	Human	None	HEK 293T cells	P22681;Q96B97	867;30011	MI:0007-anti tag coimmunoprecipitation	GO:0006900;GO:0016050;GO:0006897	vesicle budding from membrane;vesicle organization;endocytosis	20.09.07.25;20.09.18.09.01	vesicle formation;endocytosis	11894095	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase CBL;SH3 domain-containing kinase-binding protein 1	CBL;SH3KBP1	CBL2 RNF55;CIN85
5721	CIN85-CBL-SH3GL2 complex	Human	None	HEK 293T cells	P22681;Q96B97;Q99962	867;30011;6456	MI:0019-coimmunoprecipitation	GO:0006900;GO:0016050;GO:0006897	vesicle budding from membrane;vesicle organization;endocytosis	20.09.07.25;20.09.18.09.01	vesicle formation;endocytosis	11894095	Endogenous or overexpressed Cbl co-precipitated with endophilin A1 only in the presence of CIN85, indicating that CIN85 acts as a linker between Cbl and endophilins.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase CBL;SH3 domain-containing kinase-binding protein 1;Endophilin-A1	CBL;SH3KBP1;SH3GL2	CBL2 RNF55;CIN85;CNSA2 SH3D2A
5724	CIN85-SH3GL3-CBL complex	Human	None	HEK 293T cells	P22681;Q96B97;Q99963	867;30011;6457	MI:0006-anti bait coimmunoprecipitation	GO:0006900;GO:0016050;GO:0006897;GO:0007169	vesicle budding from membrane;vesicle organization;endocytosis;transmembrane receptor protein tyrosine kinase signaling pathway	20.09.07.25;20.09.18.09.01;30.05.01.12	vesicle formation;endocytosis;transmembrane receptor protein tyrosine kinase signalling pathways	11894096	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase CBL;SH3 domain-containing kinase-binding protein 1;Endophilin-A3	CBL;SH3KBP1;SH3GL3	CBL2 RNF55;CIN85;CNSA3 SH3D2C
5727	TBP-TAF complex	Human	None	HeLa cells	P20226;Q15572;Q15573;Q53T94	6908;9013;9015;9014	MI:0004-affinity chromatography technology;MI:0047-far western blotting	GO:0006351;GO:0003677	DNA-templated transcription;DNA binding	11;16.03.01	TRANSCRIPTION;DNA binding	7801123	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	TATA-box-binding protein;TATA box-binding protein-associated factor RNA polymerase I subunit C;TATA box-binding protein-associated factor RNA polymerase I subunit A;TATA box-binding protein-associated factor RNA polymerase I subunit B	TBP;TAF1C;TAF1A;TAF1B	GTF2D1 TF2D TFIID;None;None;None
5730	IKBKG homotrimer complex	Human	None	None	Q9Y6K9	8517	MI:0018-two hybrid;MI:0030-cross-linking study	GO:0007249	I-kappaB kinase/NF-kappaB signaling	30.01.05.01.04	NIK-I-kappaB/NF-kappaB cascade	12435599	None	None	None	Homo sapiens (Human)	NF-kappa-B essential modulator	IKBKG	FIP3, NEMO
5731	NRP1-VEGFC complex, heparin dependent	Human	None	HDMVEC cells	O14786;P49767	8829;7424	MI:0004-affinity chromatography technology	GO:0006898;GO:0007169;GO:0001525;GO:0030133	receptor-mediated endocytosis;transmembrane receptor protein tyrosine kinase signaling pathway;angiogenesis;transport vesicle	20.09.18.09.01.01;30.05.01.12;41.05.16;70.09	receptor-mediated endocytosis;transmembrane receptor protein tyrosine kinase signalling pathways;angiogenesis;intracellular transport vesicles	16816121	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Neuropilin-1;Vascular endothelial growth factor C	NRP1;VEGFC	NRP, VEGF165R;None
5732	NRP2-VEGFC complex	Human	None	HDMVEC cells	O60462;P49767	8828;7424	MI:0004-affinity chromatography technology;MI:0428-imaging technique	GO:0006898;GO:0007169;GO:0001525;GO:0030133	receptor-mediated endocytosis;transmembrane receptor protein tyrosine kinase signaling pathway;angiogenesis;transport vesicle	20.09.18.09.01.01;30.05.01.12;41.05.16;70.09	receptor-mediated endocytosis;transmembrane receptor protein tyrosine kinase signalling pathways;angiogenesis;intracellular transport vesicles	16816121	VEGFC colocalizes with NRP2 in endocytotic vesicles.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Neuropilin-2;Vascular endothelial growth factor C	NRP2;VEGFC	VEGF165R2;None
5733	NRP2-VEGFD complex, heparin dependent	Human	None	HDMVEC cells	O43915;O60462	2277;8828	MI:0004-affinity chromatography technology;MI:0428-imaging technique	GO:0006898;GO:0007169;GO:0001525;GO:0030133	receptor-mediated endocytosis;transmembrane receptor protein tyrosine kinase signaling pathway;angiogenesis;transport vesicle	20.09.18.09.01.01;30.05.01.12;41.05.16;70.09	receptor-mediated endocytosis;transmembrane receptor protein tyrosine kinase signalling pathways;angiogenesis;intracellular transport vesicles	16816121	VEGFD colocalizes with NRP2 in endocytotic vesicles.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Vascular endothelial growth factor D;Neuropilin-2	VEGFD;NRP2	FIGF;VEGF165R2
5734	NRP1-VEGFD complex, heparin dependent	Human	None	HDMVEC cells	O14786;O43915	8829;2277	MI:0004-affinity chromatography technology	GO:0006898;GO:0007169;GO:0001525;GO:0030133	receptor-mediated endocytosis;transmembrane receptor protein tyrosine kinase signaling pathway;angiogenesis;transport vesicle	20.09.18.09.01.01;30.05.01.12;41.05.16;70.09	receptor-mediated endocytosis;transmembrane receptor protein tyrosine kinase signalling pathways;angiogenesis;intracellular transport vesicles	16816121	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Neuropilin-1;Vascular endothelial growth factor D	NRP1;VEGFD	NRP, VEGF165R;FIGF
5735	SMAD3-TGFBR1-TGFBR2 complex	Human	SMAD3-TGF-beta receptor complex	SW480.7 cells, 293 cells	P36897;P37173;P84022	7046;7048;4088	MI:0018-two hybrid;MI:0019-coimmunoprecipitation	GO:0007179;GO:0008083	transforming growth factor beta receptor signaling pathway;growth factor activity	30.05.01.18.01;40.02.03.05	TGF-beta-receptor signalling pathway;growth factors	8774881	Immunoprecipitation of hMAD-3, but not hMAD-4, resulted in coprecipitation of ligand-bound RI-RII complex, but not RII alone.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	TGF-beta receptor type-1;TGF-beta receptor type-2;Mothers against decapentaplegic homolog 3	TGFBR1;TGFBR2;SMAD3	ALK5 SKR4;None;MADH3
5736	Pre-initiation complex (ACTB, POLR2A, TBP)	Human	PIC	HeLa cells	P20226;P24928;P60709	6908;5430;60	MI:0019-coimmunoprecipitation;MI:0047-far western blotting;MI:0402-chromatin immunoprecipitation assay	GO:0006352;GO:0003676;GO:0005634	DNA-templated transcription initiation;nucleic acid binding;nucleus	11.02.03.01.01;16.03;70.10	transcription initiation;nucleic acid binding;nucleus	15502823	Actin is required for the initiation of transcription (for the formation of pre-initiation complexes).	TBP is required for actin to bind to the DNA.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	TATA-box-binding protein;DNA-directed RNA polymerase II subunit RPB1;Actin, cytoplasmic 1	TBP;POLR2A;ACTB	GTF2D1 TF2D TFIID;POLR2;None
5740	NRP2-VEGFR3 complex	Human	None	HDMVEC cells	O60462;P35916	8828;2324	MI:0004-affinity chromatography technology	GO:0006898;GO:0007169;GO:0001525;GO:0030133	receptor-mediated endocytosis;transmembrane receptor protein tyrosine kinase signaling pathway;angiogenesis;transport vesicle	20.09.18.09.01.01;30.05.01.12;41.05.16;70.09	receptor-mediated endocytosis;transmembrane receptor protein tyrosine kinase signalling pathways;angiogenesis;intracellular transport vesicles	16816121	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Neuropilin-2;Vascular endothelial growth factor receptor 3	NRP2;FLT4	VEGF165R2;VEGFR3
5745	PlexinA1-NRP1 complex	Human	None	HEK 293T cells	O14786;Q9UIW2	8829;5361	MI:0007-anti tag coimmunoprecipitation	GO:0023052;GO:0007399;GO:0031175	signaling;nervous system development;neuron projection development	30.01;47.03.01	cellular signalling;nervous system	10520994	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Neuropilin-1;Plexin-A1	NRP1;PLXNA1	NRP, VEGF165R;NOV PLXN1
5746	NRP1-PLXNA1-SEMA3A complex	Human	NRP1-PlexinA1-SEMA3A complex; Neuropilin-PlexinA1-Sema3A complex; PlexinA1-NRP1-SEMA3A complex	HEK 293T cells	O14786;Q14563;Q9UIW2	8829;10371;5361	MI:0007-anti tag coimmunoprecipitation	GO:0071526	semaphorin-plexin signaling pathway	None	None	10520994	Plexin A increases Neuropilin 1 affinity for SEMA3A.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Neuropilin-1;Semaphorin-3A;Plexin-A1	NRP1;SEMA3A;PLXNA1	NRP, VEGF165R;SEMAD;NOV PLXN1
5747	2AR-mGluR2 complex	Human	None	brain cortex	P08913;P42262	150;2891	MI:0006-anti bait coimmunoprecipitation	GO:0007186;GO:0097332	G protein-coupled receptor signaling pathway;response to antipsychotic drug	30.05.02.24	G-protein coupled receptor signalling pathway	18297054	The results are consistent with the hypothesis that the 2AR-mGluR2 complex integrates serotonin and glutamate signaling to regulate the sensory gating functions of the cortex, a process that is disrupted in psychosis.	2AR-mGluR2 complex is involved in psychosis.	None	Homo sapiens (Human);Homo sapiens (Human)	Alpha-2A adrenergic receptor;Glutamate receptor 2	ADRA2A;GRIA2	ADRA2R ADRAR;GLUR2
5748	2AR-mGluR2 complex	Human	None	HEK 293 cells	P08913;P42262	150;2891	MI:0007-anti tag coimmunoprecipitation;MI:0012-bioluminescence resonance energy transfer;MI:0055-fluorescent resonance energy transfer	GO:0007186	G protein-coupled receptor signaling pathway	30.05.02.24	G-protein coupled receptor signalling pathway	18297054	The results are consistent with the hypothesis that the 2AR-mGluR2 complex integrates serotonin and glutamate signalling to regulate the sensory gating functions of the cortex, a process that is disrupted in psychosis.	2AR-mGluR2 complex is involved in psychosis.	None	Homo sapiens (Human);Homo sapiens (Human)	Alpha-2A adrenergic receptor;Glutamate receptor 2	ADRA2A;GRIA2	ADRA2R ADRAR;GLUR2
5749	MRIT complex	Human	BCL2L1-CASP8-CFLAR complex	HeLa cells; human adult tissue; BHK cells	O15519;Q07817;Q14790	8837;598;841	MI:0018-two hybrid;MI:0019-coimmunoprecipitation;MI:0047-far western blotting	GO:0006919;GO:0008219;GO:0089720	activation of cysteine-type endopeptidase activity involved in apoptotic process;cell death;caspase binding	40.10.02.02.02;40.10	caspase activation;cell death	9326610	MRIT simultaneously and independently interacts with BclXL and FLICE in mammalian cells.	None	MRIT may function as a crucial link between cell survival and cell death pathways in mammalian cells.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	CASP8 and FADD-like apoptosis regulator;Bcl-2-like protein 1;Caspase-8	CFLAR;BCL2L1;CASP8	CASH CASP8AP1 CLARP MRIT;BCL2L BCLX;MCH5
5755	SUA1-SUMO1-UBA2 complex	Human	None	HeLa cells; expression in Sf-9 cells	P63165;Q9UBE0;Q9UBT2	7341;10055;10054	MI:0047-far western blotting	GO:0016925;GO:0016926	protein sumoylation;protein desumoylation	14.07.07	modification by ubiquitin-related proteins	9920803	Sua1p and hUba2p form a complex, and the complexed hUba2p binds SUMO-1.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Small ubiquitin-related modifier 1;SUMO-activating enzyme subunit 1;SUMO-activating enzyme subunit 2	SUMO1;SAE1;UBA2	SMT3C SMT3H3 UBL1;AOS1 SUA1 UBLE1A;SAE2 UBLE1B
5756	SUA1-UBA2 complex	Human	None	HeLa cells; expression in Sf-9 cells	Q9UBE0;Q9UBT2	10055;10054	MI:0047-far western blotting	GO:0016925	protein sumoylation	14.07.07	modification by ubiquitin-related proteins	9920803	Human Uba2 bound SUMO-1 and this complex had the activity of the SUMO-1 activating enzyme.	None	None	Homo sapiens (Human);Homo sapiens (Human)	SUMO-activating enzyme subunit 1;SUMO-activating enzyme subunit 2	SAE1;UBA2	AOS1 SUA1 UBLE1A;SAE2 UBLE1B
5757	PLXNA1-RANBPM complex	Human	None	HEK 293T cells	Q96S59;Q9UIW2	10048;5361	MI:0007-anti tag coimmunoprecipitation	GO:0000301;GO:0023052;GO:0031175	retrograde transport, vesicle recycling within Golgi;signaling;neuron projection development	20.09.07.07;30.01	retrograde transport;cellular signalling	16672672	RanBPM has the potential to link Plexin-A receptors to retrograde transport and microtubule function in axonal guidance.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Ran-binding protein 9;Plexin-A1	RANBP9;PLXNA1	RANBPM;NOV PLXN1
5758	PLXNA2-RANBPM complex	Human	None	HEK 293T cells	O75051;Q96S59	5362;10048	MI:0007-anti tag coimmunoprecipitation	GO:0000301;GO:0023052;GO:0031175	retrograde transport, vesicle recycling within Golgi;signaling;neuron projection development	20.09.07.07;30.01	retrograde transport;cellular signalling	16672672	RanBPM has the potential to link Plexin-A receptors to retrograde transport and microtubule function in axonal guidance.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Plexin-A2;Ran-binding protein 9	PLXNA2;RANBP9	KIAA0463 OCT PLXN2;RANBPM
5759	PLXNA3-RANBPM complex	Human	None	HEK 293T cells	P51805;Q96S59	55558;10048	MI:0007-anti tag coimmunoprecipitation	GO:0000301;GO:0023052;GO:0031175	retrograde transport, vesicle recycling within Golgi;signaling;neuron projection development	20.09.07.07;30.01	retrograde transport;cellular signalling	16672672	RanBPM has the potential to link Plexin-A receptors to retrograde transport and microtubule function in axonal guidance.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Plexin-A3;Ran-binding protein 9	PLXNA3;RANBP9	PLXN4 SEX;RANBPM
5760	PLXNA4-RANBPM complex	Human	None	HEK 293T cells	Q96S59;Q9HCM2	10048;91584	MI:0007-anti tag coimmunoprecipitation	GO:0000301;GO:0023052;GO:0031175	retrograde transport, vesicle recycling within Golgi;signaling;neuron projection development	20.09.07.07;30.01	retrograde transport;cellular signalling	16672672	RanBPM has the potential to link Plexin-A receptors to retrograde transport and microtubule function in axonal guidance.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Ran-binding protein 9;Plexin-A4	RANBP9;PLXNA4	RANBPM;KIAA1550 PLXNA4A PLXNA4B
5762	CRMP-MICAL-PlexinA1 complex, induced by SEMA3A	Human	None	HEK 293T cells	Q14194;Q8TDZ2;Q9UIW2	1400;64780;5361	MI:0007-anti tag coimmunoprecipitation	GO:0023052;GO:0007399;GO:0031175	signaling;nervous system development;neuron projection development	30.01;47.03.01	cellular signalling;nervous system	18305261	MIDCAL1 forms a SEMA3A-modulated complex with CRMP and PlexA proteins.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Dihydropyrimidinase-related protein 1;[F-actin]-monooxygenase MICAL1;Plexin-A1	CRMP1;MICAL1;PLXNA1	DPYSL1, ULIP3;MICAL NICAL;NOV PLXN1
5770	RUNX1-CBF-beta-DNA complex	Human	None	None	Q01196;Q13951	861;865	MI:0114-x-ray crystallography	GO:2001141;GO:0006355;GO:0003677	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;DNA binding	11.02.03.04;16.03.01	transcriptional control;DNA binding	11276260	The heterodimeric complex between AML1 and CBF beta has an essential role in the ontogeny of definitive hematopoiesis and is the most frequent target for chromosomal rearrangements in human acute leukemias.	The complex is involved in acute leukemias.	None	Homo sapiens (Human);Homo sapiens (Human)	Runt-related transcription factor 1;Core-binding factor subunit beta	RUNX1;CBFB	AML1; CBFA2;None
5772	ZO1-(beta)cadherin-(VE)cadherin-VEGFR2 complex	Human	None	HUVEC cells	P33151;P35222;P35968;Q07157	1003;1499;3791;7082	MI:0006-anti bait coimmunoprecipitation	GO:0007169;GO:0001525;GO:0007043;GO:0001568;GO:0001944	transmembrane receptor protein tyrosine kinase signaling pathway;angiogenesis;cell-cell junction assembly;blood vessel development;vasculature development	30.05.01.12;41.05.16;42.06.04;47.03.03.02	transmembrane receptor protein tyrosine kinase signalling pathways;angiogenesis;intercellular junction (gap junction/adherens junction);vessels	18662404	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cadherin-5;Catenin beta-1;Vascular endothelial growth factor receptor 2;Tight junction protein ZO-1	CDH5;CTNNB1;KDR;TJP1	None;CTNNB;FLK1 VEGFR2;ZO1
5798	Death induced signaling complex II (CASP8, CFLAR, FADD), cytosolic, CD95L induced	Human	None	SKW 6.4 cells; BJAB cells; Raji cells; HUT78 cells; J16 cells	O15519;Q13158;Q14790	8837;8772;841	MI:0006-anti bait coimmunoprecipitation	GO:0089720;GO:0008219	caspase binding;cell death	40.10	cell death	18635548	In contrast to the caspase activation at the CD95 DISC reported to occur within seconds after stimulation, caspase activation in the cytosol took place hours after stimulation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	CASP8 and FADD-like apoptosis regulator;FAS-associated death domain protein;Caspase-8	CFLAR;FADD;CASP8	CASH CASP8AP1 CLARP MRIT;MORT1;MCH5
5799	DISC complex (FAS, FADD, CASP8, CFLAR), membrane-associated, CD95L induced	Human	Death induced signaling complex (DISC)	SKW 6.4 cells	O15519;P25445;Q13158;Q14790	8837;355;8772;841	MI:0006-anti bait coimmunoprecipitation	GO:0097190	apoptotic signaling pathway	40.10.02.03.01	induction of apoptosis by extracellular signals	18635548	The CD95 DISC is formed within seconds after CD95 stimulation, followed by caspase-8 activation at the DISC complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	CASP8 and FADD-like apoptosis regulator;Tumor necrosis factor receptor superfamily member 6;FAS-associated death domain protein;Caspase-8	CFLAR;FAS;FADD;CASP8	CASH CASP8AP1 CLARP MRIT;APT1 FAS1 TNFRSF6;MORT1;MCH5
5800	DISC complex (FAS, FADD, CASP8)	Human	Death-inducing signaling complex (DISC)	SKW 6.4 cells, H9 cells	P25445;Q13158;Q14790	355;8772;841	MI:0006-anti bait coimmunoprecipitation	GO:0006915;GO:0005886;GO:0097191	apoptotic process;plasma membrane;extrinsic apoptotic signaling pathway	40.10.02;70.02	apoptosis (type I programmed cell death);eukaryotic plasma membrane / membrane attached	9501089	The authors compared the formation of the DISC between typeI (SKW6.5, H9) and type II  (JUrkat, CEM) cells. In type I cells, induction of apoptosis was accompanied by activation of large amounts of caspase-8 by the death-inducing signaling complex (DISC), whereas in type II cells DISC formation was strongly reduced and activation of caspase-8 and caspase-3 occurred following the loss of mitochondrial transmembrane potential.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Tumor necrosis factor receptor superfamily member 6;FAS-associated death domain protein;Caspase-8	FAS;FADD;CASP8	APT1 FAS1 TNFRSF6;MORT1;MCH5
5805	KEAP1-NRF2-PGAM5 complex	Human	None	HEK 293T cells, COS-1 cells	Q14145;Q16236;Q96HS1	9817;4780;192111	MI:0006-anti bait coimmunoprecipitation	GO:2001141;GO:0006355;GO:0000302;GO:0005741	regulation of RNA biosynthetic process;regulation of DNA-templated transcription;response to reactive oxygen species;mitochondrial outer membrane	11.02.03.04;32.01.01;70.16.01	transcriptional control;oxidative stress response;mitochondrial outer membrane	18387606	The authors describe that PGAM5, by anchoring the Keap1-Nrf2 complex to outer membrane of mitochondria, may facilitate coordination between mitochondrial function and regulation of Nrf2-dependent anti-oxidant gene expression.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Kelch-like ECH-associated protein 1;Nuclear factor erythroid 2-related factor 2;Serine/threonine-protein phosphatase PGAM5, mitochondrial	KEAP1;NFE2L2;PGAM5	INRF2 KIAA0132 KLHL19;NRF2;None
5808	DISC complex (CD95, FADD, CASP8)	Human	Death inducing signaling complex	HCT116 cells	Q13158;Q14790;Q8IUB6	8772;841;355	MI:0019-coimmunoprecipitation	GO:0097190	apoptotic signaling pathway	40.10.02.03.01	induction of apoptosis by extracellular signals	19347032	This complex formation was induced by 5-FU.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	FAS-associated death domain protein;Caspase-8;CD95 antigen	FADD;CASP8;CD95	MORT1;MCH5;None
5809	GABA-A receptor (GABRA1, GABRB2, GABRG2)	Human	None	None	P14867;P18507;P47870	2554;2566;2561	MI:0401-biochemical	GO:0006821;GO:0005216	chloride transport;ion channel activity	20.01.01.07.09;20.03.01.01	chloride transport;ion channels	11992121	None	Epilepsy, juvenile mioclonic.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Gamma-aminobutyric acid receptor subunit alpha-1;Gamma-aminobutyric acid receptor subunit gamma-2;Gamma-aminobutyric acid receptor subunit beta-2	GABRA1;GABRG2;GABRB2	None;None;None
5811	p53-BCL2 complex	Human	None	H1299 cells	P04637;P10415	7157;596	MI:0019-coimmunoprecipitation	GO:0006915;GO:0005739	apoptotic process;mitochondrion	40.10.02;70.16	apoptosis (type I programmed cell death);mitochondrion	12667443	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cellular tumor antigen p53;Apoptosis regulator Bcl-2	TP53;BCL2	P53;None
5812	p53-BCL2 complex	Human	None	None	P04637;Q07817	7157;598	MI:0019-coimmunoprecipitation	GO:0006915;GO:0005739	apoptotic process;mitochondrion	40.10.02;70.16	apoptosis (type I programmed cell death);mitochondrion	12667443	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cellular tumor antigen p53;Bcl-2-like protein 1	TP53;BCL2L1	P53;BCL2L BCLX
5816	Apoptosome, 700 kDa	Human	APAF1-CASP9-CYCS complex	None	O14727;P55211;P99999	317;842;54205	MI:0226-ion exchange chromatography	GO:0006915;GO:0005737	apoptotic process;cytoplasm	40.10.02;70.03	apoptosis (type I programmed cell death);cytoplasm	10692394	Cytochrome C binds to Apaf-1 to form a procaspase-9-activating heptameric protein complex named apoptosome. (PMID:16251271)	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Apoptotic protease-activating factor 1;Caspase-9;Cytochrome c	APAF1;CASP9;CYCS	KIAA0413;MCH6;CYC
5823	MCL1-BAK1 complex	Human	None	None	Q07820;Q16611	4170;578	MI:0019-coimmunoprecipitation	GO:0043067;GO:0005741	regulation of programmed cell death;mitochondrial outer membrane	40.10.02.04;70.16.01	regulation of apoptosis;mitochondrial outer membrane	15077116	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Induced myeloid leukemia cell differentiation protein Mcl-1;Bcl-2 homologous antagonist/killer	MCL1;BAK1	BCL2L3;BAK BCL2L7 CDN1
5827	IKBKG homotetramer complex	Human	None	HeLa cells	Q9Y6K9	8517	MI:0030-cross-linking study	GO:0007249	I-kappaB kinase/NF-kappaB signaling	30.01.05.01.04	NIK-I-kappaB/NF-kappaB cascade	12612076	Cross link agent EGS appears to cross-link preferentially the IKK-gamma subunits in the IKK-alpha-IKK-beta-IKK-gamma holocomplex.	None	None	Homo sapiens (Human)	NF-kappa-B essential modulator	IKBKG	FIP3, NEMO
5828	IKBKG-IKBKB  complex	Human	None	HeLa cells	O14920;Q9Y6K9	3551;8517	MI:0007-anti tag coimmunoprecipitation	GO:0007249	I-kappaB kinase/NF-kappaB signaling	30.01.05.01.04	NIK-I-kappaB/NF-kappaB cascade	12612076	The tetrameric oligomerization is not required for binding of IKK-gamma to IKK-alpha or IKK-beta.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Inhibitor of nuclear factor kappa-B kinase subunit beta;NF-kappa-B essential modulator	IKBKB;IKBKG	IKKB;FIP3, NEMO
5829	IKBKG-CHUK complex	Human	None	HeLa cells	O15111;Q9Y6K9	1147;8517	MI:0007-anti tag coimmunoprecipitation	GO:0007249	I-kappaB kinase/NF-kappaB signaling	30.01.05.01.04	NIK-I-kappaB/NF-kappaB cascade	12612076	The tetrameric oligomerization is not required for binding of IKK-gamma to IKK-alpha or IKK-beta.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Inhibitor of nuclear factor kappa-B kinase subunit alpha;NF-kappa-B essential modulator	CHUK;IKBKG	IKKA TCF16;FIP3, NEMO
5830	DJ-1-SNCA complex, high molecular weight	Human	PARK7-SNCA complex	brain	P37840;Q99497	6622;11315	MI:0006-anti bait coimmunoprecipitation;MI:0071-molecular sieving	None	None	None	None	15935068	None	The interaction of DJ-1 and alpha-synuclein may have a mechanistic role in disease. Both proteins are mutated in forms of inherited parkinsonism.	None	Homo sapiens (Human);Homo sapiens (Human)	Alpha-synuclein;Parkinson disease protein 7	SNCA;PARK7	NACP PARK1;None
5832	PINK1-RHOT2-TRAK1 complex	Human	PINK1-MIRO2-Milton complex	COS7	Q8IXI1;Q9BXM7;Q9UPV9	89941;65018;22906	MI:0007-anti tag coimmunoprecipitation	GO:0016192;GO:0005741	vesicle-mediated transport;mitochondrial outer membrane	20.09.07;70.16.01	vesicular transport (Golgi network, etc.);mitochondrial outer membrane	19152501	This complex is involved in anterograde axonal transport of mitochondria.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mitochondrial Rho GTPase 2;Serine/threonine-protein kinase PINK1, mitochondrial;Trafficking kinesin-binding protein 1	RHOT2;PINK1;TRAK1	ARHT2 C16orf39;None;KIAA1042 OIP106
5836	RHOT2-TRAK1 complex	Human	MIRO2-Milton complex	COS7	Q8IXI1;Q9UPV9	89941;22906	MI:0007-anti tag coimmunoprecipitation	GO:0016192;GO:0005741	vesicle-mediated transport;mitochondrial outer membrane	20.09.07;70.16.01	vesicular transport (Golgi network, etc.);mitochondrial outer membrane	19152501	This complex is involved in anterograde axonal transport of mitochondria.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Mitochondrial Rho GTPase 2;Trafficking kinesin-binding protein 1	RHOT2;TRAK1	ARHT2 C16orf39;KIAA1042 OIP106
5837	PPD complex	Human	Parkin-PINK1-DJ1 complex	brain	O60260;Q99497;Q9BXM7	5071;11315;65018	MI:0019-coimmunoprecipitation;MI:0071-molecular sieving	GO:0043161;GO:0006511;GO:0005737	proteasome-mediated ubiquitin-dependent protein catabolic process;ubiquitin-dependent protein catabolic process;cytoplasm	14.13.01.01;70.03	proteasomal degradation (ubiquitin/proteasomal pathway);cytoplasm	19229105	PPD complex plays an important role in degradation of un- or misfolded Parkin substrates, like Parkin itself or Synphilin-1. Usually the PPD complex is found in the cytoplasm, but a small ammount was also detected in the mitochondrial fraction.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase parkin;Parkinson disease protein 7;Serine/threonine-protein kinase PINK1, mitochondrial	PRKN;PARK7;PINK1	PARK2;None;None
5843	AIF-CYPA-DNA complex	Human	None	Jurkat cells	O95831;P62937	9131;5478	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0006915;GO:0005634	apoptotic process;nucleus	40.10.02;70.10	apoptosis (type I programmed cell death);nucleus	14716299	After apoptotic stimulus, AIF translocates to the nucleus, interacts with DNA and tethers CypA to chromatin.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Apoptosis-inducing factor 1, mitochondrial;Peptidyl-prolyl cis-trans isomerase A	AIFM1;PPIA	AIF, PDCD8;CYPA
5844	I-kappa-B kinase complex	Human	IKK complex; CHUK-IKBKB-IKBKG complex	HeLa cells	O14920;O15111;Q9Y6K9	3551;1147;8517	MI:0007-anti tag coimmunoprecipitation;MI:0071-molecular sieving	GO:0007249;GO:0006954;GO:0045087;GO:0051607;GO:0007249;GO:0008384;GO:0051090;GO:0008385;GO:0019048	I-kappaB kinase/NF-kappaB signaling;inflammatory response;innate immune response;defense response to virus;I-kappaB kinase/NF-kappaB signaling;IkappaB kinase activity;regulation of DNA-binding transcription factor activity;IkappaB kinase complex;modulation by virus of host process	30.01.05.01.04;36.25.16.07;36.25.16.01;18.02.09	NIK-I-kappaB/NF-kappaB cascade;inflammatory response;innate immune response (invertebrates and vertebrates);regulator of transcription factor	10893415	The authors conclude that while IKK gamma is a stoichiometric component of the IKK complex, obligatory for NF-kappa B signaling, IKAP is not associated with IKKs and plays no specific role in cytokine-induced NF-kappa B activation (PMID:10893415). Vaccinia virus strain Western Reserve B14 protein interacts with IKKbeta and inhibits NF-kappaB activation catalyzed by the I-kappaB kinase complex (PMID:18266467).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Inhibitor of nuclear factor kappa-B kinase subunit beta;Inhibitor of nuclear factor kappa-B kinase subunit alpha;NF-kappa-B essential modulator	IKBKB;CHUK;IKBKG	IKKB;IKKA TCF16;FIP3, NEMO
5849	HSP90-CDC37-LRRK2 complex	Human	None	HEK 293 cells	P08238;Q16543;Q5S007	3326;11140;120892	MI:0676-tandem affinity purification	GO:0035556	intracellular signal transduction	30.01	cellular signalling	16321986	HSP90 and CDC37 do not serve as substrate for LRRK2 kinase but associates as chaperones participating in maintenance of proper folding of the kinase.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Heat shock protein HSP 90-beta;Hsp90 co-chaperone Cdc37;Leucine-rich repeat serine/threonine-protein kinase 2	HSP90AB1;CDC37;LRRK2	HSP90B HSPC2 HSPCB;CDC37A;PARK8
5856	AK2-FADD-caspase-10 (AFAC10) complex	Human	None	Hela cells	P54819;Q13158;Q92851	204;8772;843	MI:0071-molecular sieving;MI:0096-pull down	GO:0097193	intrinsic apoptotic signaling pathway	40.10.02.03.02	induction of apoptosis by intracellular signals	17952061	AFAC10 complexes are detected in cells undergoing intrinsic cell death and AK2 promotes the association of caspase-10 with FADD. AK2 mediates a novel intrinsic apoptotic pathway that may be involved in tumorigenesis.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Adenylate kinase 2, mitochondrial;FAS-associated death domain protein;Caspase-10	AK2;FADD;CASP10	ADK2;MORT1;MCH4
5859	FAS-FADD-CASP8-CASP10 complex	Human	None	None	P25445;Q13158;Q14790;Q92851	355;8772;841;843	MI:0006-anti bait coimmunoprecipitation;MI:0055-fluorescent resonance energy transfer	GO:0006915	apoptotic process	40.10.02	apoptosis (type I programmed cell death)	11717445	Stimulation of Fas was induced by anti-Fas or by FasL. The FRET-results suggest that caspase-8 and -10 can be recruited likely within 50 \u00c5, which would constitute the same Fas signaling complex. Caspase-10 is recruited into the Fas signaling complex and becomes activated like caspase-8 with slightly faster kinetics under these conditions. FRET signals showed pairs of of caspase-8 and -10 DEDs (death effector domains) with themselves and with each other, indicating a natural propensity of these domains to cause homotypic and heterotypic complexes.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Tumor necrosis factor receptor superfamily member 6;FAS-associated death domain protein;Caspase-8;Caspase-10	FAS;FADD;CASP8;CASP10	APT1 FAS1 TNFRSF6;MORT1;MCH5;MCH4
5860	DISC complex (FAS, FADD, CASP8)	Human	FAS-FADD-CASP8 complex	None	P25445;Q13158;Q14790	355;8772;841	MI:0055-fluorescent resonance energy transfer	GO:0006915	apoptotic process	40.10.02	apoptosis (type I programmed cell death)	11717445	Stimulation of Fas was induced by anti-Fas or by FasL. FRET signals showed pairs of of caspase-8 and -10 DEDs (death effector domains) with themselves and with each other, indicating a natural propensity of these domains to cause homotypic and heterotypic complexes.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Tumor necrosis factor receptor superfamily member 6;FAS-associated death domain protein;Caspase-8	FAS;FADD;CASP8	APT1 FAS1 TNFRSF6;MORT1;MCH5
5861	FAS-FADD-CASP10 complex	Human	None	None	P25445;Q13158;Q92851	355;8772;843	MI:0055-fluorescent resonance energy transfer	GO:0006915	apoptotic process	40.10.02	apoptosis (type I programmed cell death)	11717445	Stimulation of Fas was induced by anti-Fas or by FasL.  FRET signals showed pairs of of caspase-8 and -10 DEDs (death effector domains) with themselves and with each other, indicating a natural propensity of these domains to cause homotypic and heterotypic complexes.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Tumor necrosis factor receptor superfamily member 6;FAS-associated death domain protein;Caspase-10	FAS;FADD;CASP10	APT1 FAS1 TNFRSF6;MORT1;MCH4
5862	CAV1-VDAC1-ESR1 complex	Human	None	cortical and hippocampal areas	P03372;P21796;Q03135	2099;7416;857	MI:0006-anti bait coimmunoprecipitation;MI:0663-confocal microscopy	GO:0005216;GO:0005886	ion channel activity;plasma membrane	20.03.01.01;70.02	ion channels;eukaryotic plasma membrane / membrane attached	19595769	None	Disease: CAV1-VDAC1-ESR1 complex is involved in Alzheimer's disease.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Estrogen receptor;Voltage-dependent anion-selective channel protein 1;Caveolin-1	ESR1;VDAC1;CAV1	ESR NR3A1;VDAC;CAV
5870	APBB1-TSHZ3-HDAC1 complex	Human	FE65-TSHZ3-HDAC1 complex	human H4 neuroglioma cells	O00213;Q13547;Q63HK5	322;3065;57616	MI:0007-anti tag coimmunoprecipitation	GO:0045892;GO:0005634	negative regulation of DNA-templated transcription;nucleus	11.02.03.04.03;70.10	transcription repression;nucleus	19343227	CASP4 appears to be one target for the repressor complex centering on FE65.	Disease: TSHZ3 is involved in Alzheimer disease.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Amyloid beta precursor protein binding family B member 1;Histone deacetylase 1;Teashirt homolog 3	APBB1;HDAC1;TSHZ3	FE65 RIR;RPD3L1;KIAA1474 TSH3 ZNF537
5872	BRAF-MAP2K1-MAP2K2-YWHAE complex	Human	None	HEK 293	P15056;P36507;P62258;Q02750	673;5605;7531;5604	MI:0676-tandem affinity purification	GO:0023052	signaling	30.01	cellular signalling	17979178	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein kinase B-raf;Dual specificity mitogen-activated protein kinase kinase 2;14-3-3 protein epsilon;Dual specificity mitogen-activated protein kinase kinase 1	BRAF;MAP2K2;YWHAE;MAP2K1	BRAF1, RAFB1;MEK2 MKK2 PRKMK2;None;MEK1 PRKMK1
5873	RAF1-MAP2K1-YWHAE complex	Human	None	HEK 293	P04049;P62258;Q02750	5894;7531;5604	MI:0676-tandem affinity purification	GO:0023052	signaling	30.01	cellular signalling	17979178	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	RAF proto-oncogene serine/threonine-protein kinase;14-3-3 protein epsilon;Dual specificity mitogen-activated protein kinase kinase 1	RAF1;YWHAE;MAP2K1	RAF;None;MEK1 PRKMK1
5876	PPP2R1A-PPP2R1B-PPP2CA-PPME1-EIF4A1 complex	Human	None	HT-1080	P30153;P30154;P60842;P67775;Q9Y570	5518;5519;1973;5515;51400	MI:0676-tandem affinity purification	GO:0006470	protein dephosphorylation	14.07.03	modification by phosphorylation, dephosphorylation, autophosphorylation	15761952	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform;Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform;Eukaryotic initiation factor 4A-I;Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform;Protein phosphatase methylesterase 1	PPP2R1A;PPP2R1B;EIF4A1;PPP2CA;PPME1	None;None;DDX2A EIF4A;None;PME1
5877	MAP2K1-BRAF-RAF1-YWHAE-KSR1 complex	Human	None	HEK 293 cells	P04049;P15056;P62258;Q02750;Q8IVT5	5894;673;7531;5604;8844	MI:0676-tandem affinity purification	GO:0023052	signaling	30.01	cellular signalling	17979178	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	RAF proto-oncogene serine/threonine-protein kinase;Serine/threonine-protein kinase B-raf;14-3-3 protein epsilon;Dual specificity mitogen-activated protein kinase kinase 1;Kinase suppressor of Ras 1	RAF1;BRAF;YWHAE;MAP2K1;KSR1	RAF;BRAF1, RAFB1;None;MEK1 PRKMK1;KSR
5918	KSR1 homo-oligomer complex	Human	None	HEK 293 cells	Q8IVT5	8844	MI:0007-anti tag coimmunoprecipitation	GO:0000165	MAPK cascade	30.01.05.01.03	MAPKKK cascade	18332145	The authors found that KSR1 homo-oligomerization is required to couple distinct KSR\u00b7MEK and KSR\u00b7B-Raf complexes to allow MEK activation.IMP (the Ras effector and ubiquitin-protein isopeptide ligase family member) association blocks KSR1 homo-oligomerization.	None	None	Homo sapiens (Human)	Kinase suppressor of Ras 1	KSR1	KSR
5919	BRAF-RAF1-14-3-3 complex	Human	None	HEK 293 cells	P04049;P15056;P63104	5894;673;7534	MI:0007-anti tag coimmunoprecipitation	GO:0000165	MAPK cascade	30.01.05.01.03	MAPKKK cascade	18332145	Expression of IMP (Ras effector and ubiquitin-protein isopeptide ligase family member)  blocked BRAF-RAF1 complex formation.Although 14-3-3 association has been implicated as a prerequisite for B-Raf\u00b7c-Raf complex formation, IMP impaired Raf hetero-oligomerization without affecting the relative amounts of 14-3-3 coprecipitating with B-Raf.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	RAF proto-oncogene serine/threonine-protein kinase;Serine/threonine-protein kinase B-raf;14-3-3 protein zeta/delta	RAF1;BRAF;YWHAZ	RAF;BRAF1, RAFB1;None
5920	KSR1-RAF1-MEK complex	Human	None	HEK 293 cells	P04049;Q02750;Q8IVT5	5894;5604;8844	MI:0007-anti tag coimmunoprecipitation	GO:0000165	MAPK cascade	30.01.05.01.03	MAPKKK cascade	18332145	IMP (Ras effector and ubiquitin-protein isopeptide ligase family member)  significantly inhibited the association of c-Raf with KSR1. This is in stark contrast to the insensitivity of KSR1\u00b7B-Raf complexes to IMP expression.	None	Since the authors did not specify Mek, we used isoform Mek1.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	RAF proto-oncogene serine/threonine-protein kinase;Dual specificity mitogen-activated protein kinase kinase 1;Kinase suppressor of Ras 1	RAF1;MAP2K1;KSR1	RAF;MEK1 PRKMK1;KSR
5921	KSR1-BRAF-MEK complex	Human	None	HEK 293 cells	P15056;Q02750;Q8IVT5	673;5604;8844	MI:0007-anti tag coimmunoprecipitation	GO:0000165	MAPK cascade	30.01.05.01.03	MAPKKK cascade	18332145	IMP (Ras effector and ubiquitin-protein isopeptide ligase family member)  significantly inhibited the association of c-Raf with KSR1. This is in stark contrast to the insensitivity of KSR1\u00b7B-Raf complexes to IMP expression.	None	Since the authors did not specify Mek, we used isoform Mek1.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein kinase B-raf;Dual specificity mitogen-activated protein kinase kinase 1;Kinase suppressor of Ras 1	BRAF;MAP2K1;KSR1	BRAF1, RAFB1;MEK1 PRKMK1;KSR
5922	RAF1-RAS complex, EGF induced	Human	None	None	P01112;P04049	3265;5894	MI:0006-anti bait coimmunoprecipitation	GO:0023052;GO:0005886	signaling;plasma membrane	30.01;70.02	cellular signalling;eukaryotic plasma membrane / membrane attached	16364920	The authors showed that whereas EGF induces complex formation between RAS and C-RAF, and (G12V)RAS binds directly to C-RAF, a RAS:C-RAF complex is not induced by the impaired activity mutants of B-RAF or by (V600E)B-RAF.	None	None	Homo sapiens (Human);Homo sapiens (Human)	GTPase HRas;RAF proto-oncogene serine/threonine-protein kinase	HRAS;RAF1	HRAS1;RAF
5923	RAF1-BRAF complex, RAS stimulated	Human	None	Cos cells	P04049;P15056	5894;673	MI:0007-anti tag coimmunoprecipitation	GO:0023052	signaling	30.01	cellular signalling	16364920	The authors found that C-RAF binds to B-RAF only under activating conditions, whereas mutant B-RAF binds to C-RAF constitutively. Additionally they showed that wild-type B-RAF can also activate C-RAF, but that C-RAF does not activate B-RAF.	None	None	Homo sapiens (Human);Homo sapiens (Human)	RAF proto-oncogene serine/threonine-protein kinase;Serine/threonine-protein kinase B-raf	RAF1;BRAF	RAF;BRAF1, RAFB1
5924	RAF1-CNK1 complex, RAS stimulated	Human	None	HEK 293T cells	P04049;Q969H4	5894;10256	MI:0007-anti tag coimmunoprecipitation	GO:0023052	signaling	30.01	cellular signalling	15845549	The authors described that the interaction between the wild-type proteins of Raf and CNK was detectable but weak. Further they showed that coexpression of activated RasV12 enhanced the association between the two proteins, indicating that Raf-1 preactivated by RasV12 undergoes a conformational change that improves its binding to CNK1.	None	None	Homo sapiens (Human);Homo sapiens (Human)	RAF proto-oncogene serine/threonine-protein kinase;Connector enhancer of kinase suppressor of ras 1	RAF1;CNKSR1	RAF;CNK1
5925	BRAF-CNK1 complex, not RAS stimulated	Human	None	HEK 293T cells	P15056;Q969H4	673;10256	MI:0007-anti tag coimmunoprecipitation	GO:0023052	signaling	30.01	cellular signalling	15845549	The authors showed that in contrast to Raf-1, B-Raf bound to CNK1 without the coexpression of activated Ras.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein kinase B-raf;Connector enhancer of kinase suppressor of ras 1	BRAF;CNKSR1	BRAF1, RAFB1;CNK1
5926	CNK1 homodimer complex	Human	None	HEK 293T cells	Q969H4	10256	MI:0007-anti tag coimmunoprecipitation	GO:0023052	signaling	30.01	cellular signalling	15845549	The authors showed that coexpression of activators of the MAP kinase pathway such as RasV12 or the constitutively active MEK mutant MEK-Glu-217/Glu-221  strongly induced dimerization of the CNK proteins.	None	None	Homo sapiens (Human)	Connector enhancer of kinase suppressor of ras 1	CNKSR1	CNK1
5928	CNK1-SRC-RAF1 complex	Human	None	HEK 293T cells	P04049;P12931;Q969H4	5894;6714;10256	MI:0007-anti tag coimmunoprecipitation	GO:0023052	signaling	30.01	cellular signalling	15845549	The results indicated that CNK1 regulates the Src-dependent activation of Raf-1 only under optimized conditions. Too low or too high amounts of CNK1 prevented the formation of the trimeric complex and promoted dimerization between CNK1 and Src or Raf-1, thereby preventing activation of Raf-1 by Src. The authors describe that CNK1 acts as a scaffold protein that assembles and coordinates two kinases of a single signaling pathway.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	RAF proto-oncogene serine/threonine-protein kinase;Proto-oncogene tyrosine-protein kinase Src;Connector enhancer of kinase suppressor of ras 1	RAF1;SRC;CNKSR1	RAF;SRC1;CNK1
5975	Gamma-secretase complex (APH1A, NCSTN, PSENEN, PSEN1, TMP21)	Human	None	HEK-293 cells; SHSY-5Y cells	P49755;P49768;Q92542;Q96BI3;Q9NZ42	10972;5663;23385;51107;55851	MI:0019-coimmunoprecipitation	GO:0016485;GO:0051090;GO:0007219;GO:0005886;GO:0005794;GO:0070765	protein processing;regulation of DNA-binding transcription factor activity;Notch signaling pathway;plasma membrane;Golgi apparatus;gamma-secretase complex	14.07.11;18.02.09;30.05.02.14;70.02;70.08	protein processing (proteolytic);regulator of transcription factor;Notch-receptor signalling pathway;eukaryotic plasma membrane / membrane attached;Golgi	16641999	TMP21 (TMP10), a 219-amino-acid type 1 transmembrane protein, is a member of the p24 cargo-protein family that is involved in protein transport and quality control in the endoplasmic reticulum and Golgi. TMP21 protein also resides at the plasma membrane (which is one of the principal subcellular locations for gamma- and epsilon-cleavage of many substrates).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transmembrane emp24 domain-containing protein 10;Presenilin-1;Nicastrin;Gamma-secretase subunit APH-1A;Gamma-secretase subunit PEN-2	TMED10;PSEN1;NCSTN;APH1A;PSENEN	TMP21;AD3 PS1 PSNL1;KIAA0253;PSF;PEN2
5980	LRRK2-CHIP-HSP90 complex	Human	None	None	P08238;Q5S007;Q9UNE7	3326;120892;10273	MI:0007-anti tag coimmunoprecipitation	GO:0043161;GO:0006511	proteasome-mediated ubiquitin-dependent protein catabolic process;ubiquitin-dependent protein catabolic process	14.13.01.01	proteasomal degradation (ubiquitin/proteasomal pathway)	19196961	None	LRRK2 is involved in Parkinson disease.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Heat shock protein HSP 90-beta;Leucine-rich repeat serine/threonine-protein kinase 2;E3 ubiquitin-protein ligase CHIP	HSP90AB1;LRRK2;STUB1	HSP90B HSPC2 HSPCB;PARK8;CHIP
5991	LRRK2-FADD-CASP8 complex	Human	None	HEK-293 cell	Q13158;Q14790;Q5S007	8772;841;120892	MI:0019-coimmunoprecipitation	GO:0006915	apoptotic process	40.10.02	apoptosis (type I programmed cell death)	19176810	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	FAS-associated death domain protein;Caspase-8;Leucine-rich repeat serine/threonine-protein kinase 2	FADD;CASP8;LRRK2	MORT1;MCH5;PARK8
6023	Calcineurin	Human	CaN	human proteins expressed in E.coli	P63098;Q08209	5534;5530	MI:0114-x-ray crystallography	GO:0019722;GO:0005955;GO:0005516;GO:0016791;GO:0042110	calcium-mediated signaling;calcineurin complex;calmodulin binding;phosphatase activity;T cell activation	30.01.09.03	Ca2+ mediated signal transduction	8524402	Calcineurin (CaN) is a calcium- and calmodulin-dependent protein serine/threonine phosphatase which is critical for several important cellular processes, including T-cell activation. CaN is the target of the immunosuppressive drugs cyclosporin A and FK506, which inhibit CaN after forming complexes with cytoplasmic binding proteins (cyclophilin and FKBP12, respectively). CaN is a heterodimer composed of a catalytic A unit and a regulatory B unit.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Calcineurin subunit B type 1;Protein phosphatase 3 catalytic subunit alpha	PPP3R1;PPP3CA	CNA2 CNB;CALNA CNA
6025	Ubiquitin-conjugating enzyme E2 (UBC13-UEV1A)	Human	UBC13-UEV1A complex; TRIKA1 complex; TRAF6-regulated IKK activator 1	HeLa cell	P61088;Q13404	7334;7335	MI:0071-molecular sieving	GO:0016567;GO:0070534;GO:0007249	protein ubiquitination;protein K63-linked ubiquitination;I-kappaB kinase/NF-kappaB signaling	14.07.05;30.01.05.01.04	modification by ubiquitination, deubiquitination;NIK-I-kappaB/NF-kappaB cascade	11057907	This complex supports the activation of the I-kappa-B kinase complex by TRAF6. It catalyzes the formation of a Lys 63 (K63)-linked polyubiquitin chain.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Ubiquitin-conjugating enzyme E2 N;Ubiquitin-conjugating enzyme E2 variant 1	UBE2N;UBE2V1	BLU;CROC1 UBE2V UEV1
6037	STUB1-HSPA8-MAPT-UBE2D2 complex	Human	CHIP-HSC70-TAU-UBCH5B complex	human brain; transfected COS7 cells	P10636;P11142;P62837;Q9UNE7	4137;3312;7322;10273	MI:0019-coimmunoprecipitation;MI:0069-mass spectrometry studies of complexes	GO:0016567;GO:0043161;GO:0006511	protein ubiquitination;proteasome-mediated ubiquitin-dependent protein catabolic process;ubiquitin-dependent protein catabolic process	14.07.05;14.13.01.01	modification by ubiquitination, deubiquitination;proteasomal degradation (ubiquitin/proteasomal pathway)	14612456	CHIP-HSC70 complex ubiquitinates phosphorylated Tau and enhances cell survival by decreasing the toxicity of hyperphosphorylated tau, a important factor in the neurofibrillary pathology of Alzheimer disease, via proteasomal degradation. It is shown that Alzheimer tau binds to Hsc70, and its phosphorylation is a recognition requirement for the addition of ubiquitin (Ub) by the E3 Ub ligase CHIP (carboxyl terminus of the Hsc70-interacting protein) and the E2 conjugating enzyme UbcH5B.	Alzheimer disease	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Microtubule-associated protein tau;Heat shock cognate 71 kDa protein;Ubiquitin-conjugating enzyme E2 D2;E3 ubiquitin-protein ligase CHIP	MAPT;HSPA8;UBE2D2;STUB1	MAPTL MTBT1 TAU;HSC70 HSP73 HSPA10;PUBC1 UBC4 UBC5B UBCH4 UBCH5B;CHIP
6038	Dynein complex	Human	None	HEK 293 cells	O14576;P63167;Q14204;Q9Y6G9	None;None;None;None	MI:0096-pull down	GO:0030705	cytoskeleton-dependent intracellular transport	20.09.14	cytoskeleton-dependent transport	17403682	In neurons, most autophagosomes are generated in the axon tip and undergo a dynein-mediated retrograde transport to the soma (PMID:32397599).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cytoplasmic dynein 1 intermediate chain 1;Dynein light chain 1, cytoplasmic;Cytoplasmic dynein 1 heavy chain 1;Cytoplasmic dynein 1 light intermediate chain 1	DYNC1I1;DYNLL1;DYNC1H1;DYNC1LI1	DNCI1 DNCIC1;DLC1 DNCL1 DNCLC1 HDLC1;DHC1 DNCH1 DNCL DNECL DYHC KIAA0325;DNCLI1
6039	Dynein-dynactin complex	Human	Dynein-dynactin motor complex	HEK 293 cells	O14576;P63167;Q14203;Q14204;Q9Y6G9	None;None;None;None;None	MI:0096-pull down	GO:0030705	cytoskeleton-dependent intracellular transport	20.09.14	cytoskeleton-dependent transport	17403682	The dynein-dynactin motor complex is necessary for autophagosome movement to lysosome-concentrated regions (PMID:32397599).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cytoplasmic dynein 1 intermediate chain 1;Dynein light chain 1, cytoplasmic;Dynactin subunit 1;Cytoplasmic dynein 1 heavy chain 1;Cytoplasmic dynein 1 light intermediate chain 1	DYNC1I1;DYNLL1;DCTN1;DYNC1H1;DYNC1LI1	DNCI1 DNCIC1;DLC1 DNCL1 DNCLC1 HDLC1;None;DHC1 DNCH1 DNCL DNECL DYHC KIAA0325;DNCLI1
6041	DISC1-FEZ1 complex	Human	None	None	Q99689;Q9NRI5	None;27185	MI:0018-two hybrid	GO:0000902;GO:0016049	cell morphogenesis;cell growth	40.01	cell growth / morphogenesis	12874605	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Fasciculation and elongation protein zeta-1;Disrupted in schizophrenia 1 protein	FEZ1;DISC1	None;KIAA0457
6043	DISC-FEZ1-F-actin complex	Human	None	None	P63261;Q99689;Q9NRI5	71;None;27185	MI:0019-coimmunoprecipitation	GO:0000902;GO:0016049	cell morphogenesis;cell growth	40.01	cell growth / morphogenesis	12874605	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Actin, cytoplasmic 2;Fasciculation and elongation protein zeta-1;Disrupted in schizophrenia 1 protein	ACTG1;FEZ1;DISC1	ACTG;None;KIAA0457
6046	PDE4B-DISC1 complex	Human	None	SH-SY5Y cells	Q07343;Q9NRI5	5142;27185	MI:0019-coimmunoprecipitation	GO:0006198	cAMP catabolic process	None	None	16293762	None	OMIM:181500 Schizophrenia, (PMID:17823207).	None	Homo sapiens (Human);Homo sapiens (Human)	cAMP-specific 3',5'-cyclic phosphodiesterase 4B;Disrupted in schizophrenia 1 protein	PDE4B;DISC1	DPDE4;KIAA0457
6052	BAG3-HSC70-HSPB8-CHIP complex	Human	None	HeLa cells	O95817;P11142;Q9UJY1;Q9UNE7	9531;3312;26353;10273	MI:0007-anti tag coimmunoprecipitation	GO:0050821;GO:0006457;GO:0006950	protein stabilization;protein folding;response to stress	14.01;32.01	protein folding and stabilization;stress response	20060297	The BAG3-HSC70-HSPB8-CHIP complex facilitates the degradation of damaged components, such as filamin, through chaperone-assisted selective autophagy (CASA).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	BAG family molecular chaperone regulator 3;Heat shock cognate 71 kDa protein;Heat shock protein beta-8;E3 ubiquitin-protein ligase CHIP	BAG3;HSPA8;HSPB8;STUB1	BIS;HSC70 HSP73 HSPA10;CRYAC E2IG1 HSP22;CHIP
6053	LKB1-STRAD-MO25 complex	Human	None	HEK-293 cells	Q15831;Q7RTN6;Q9Y376	6794;92335;51719	MI:0114-x-ray crystallography	GO:0006468	protein phosphorylation	14.07.03	modification by phosphorylation, dephosphorylation, autophosphorylation	19892943	LKB1 activity is regulated by the pseudokinase STRAD-alpha and the scaffolding protein MO25-alpha, through an unknown, phosphorylation-independent, mechanism. The core heterotrimeric LKB1-STRAD-alpha-MO25-alpha complex, reveals an unusual allosteric mechanism of LKB1 activation.	Loss-of-function mutations in the tumor suppressor LKB1 cause the rare inherited disease Peutz-Jeghers syndrome (PJS) in humans and are associated with various sporadic cancers, in particular non\u2013small cell lung cancer (OMIM: 175200).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein kinase STK11;STE20-related kinase adapter protein alpha;Calcium-binding protein 39	STK11;STRADA;CAB39	LKB1 PJS;LYK5 STRAD;MO25
6056	APP-TNFRSF21 complex	Human	APP-DR6 complex	human genes expressed in COS cells	O75509;P05067	27242;351	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0016322;GO:0070997	neuron remodeling;neuron death	None	None	19225519	APP binds DR6 to trigger axon pruning and neuron death via distinct caspases.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Tumor necrosis factor receptor superfamily member 21;Amyloid-beta precursor protein	TNFRSF21;APP	DR6;A4 AD1
6061	DISC1-ZNF365 complex	Human	None	None	Q70YC5;Q9NRI5	22891;27185	MI:0018-two hybrid	GO:0022008;GO:0048699	neurogenesis;generation of neurons	41.05.13	neurogenesis	19191256	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Protein ZNF365;Disrupted in schizophrenia 1 protein	ZNF365;DISC1	DBZ KIAA0844;KIAA0457
6066	Xanthine oxidase	Human	Xanthine oxidase/dehydrogenase (EC 1.17.3.2); Xanthine oxidase type D/ type O	human milk	P47989	7498	MI:0071-molecular sieving	GO:0006195;GO:0030151;GO:0070403;GO:0009114;GO:0009115	purine nucleotide catabolic process;molybdenum ion binding;NAD+ binding;hypoxanthine catabolic process;xanthine catabolic process	01.03.01.01;01.03.01.01.01;01.03.01.01.03	purine nucleotide /nucleoside/nucleobase catabolism;hypoxanthine catabolism;xanthine catabolism	1627588	Xanthine oxidase is a molybdoenzyme that catalyses the oxidation of hypoxanthine to xanthine and of xanthine to uric acid. In mammalian systems, it occurs as partially interconvertible Type D (dehydrogenase) and Type O (oxidase) forms, reducing, respectively, NAD+ or oxygen. In such systems, the term 'xanthine oxidase' commonly refers to both Type D and Type O forms.	None	None	Homo sapiens (Human)	Xanthine dehydrogenase/oxidase	XDH	XDHA
6067	ESR1-SP1 complex	Human	None	MCF-7 MDA-MB-231 HeLa	P03372;P08047	2099;6667	MI:0045-experimental interaction detection	None	None	None	None	10681512	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Estrogen receptor;Transcription factor Sp1	ESR1;SP1	ESR NR3A1;TSFP1
6068	ESR1-CEBPB complex	Human	None	MCF-7  Hep-G2	P03372;P17676	2099;1051	MI:0045-experimental interaction detection	None	None	None	None	18852215	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Estrogen receptor;CCAAT/enhancer-binding protein beta	ESR1;CEBPB	ESR NR3A1;TCF5
6069	ESR1-GRIP1 complex	Human	None	U-937	P03372;Q9Y3R0	2099;23426	MI:0045-experimental interaction detection	None	None	None	None	10611355	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Estrogen receptor;Glutamate receptor-interacting protein 1	ESR1;GRIP1	ESR NR3A1;None
6072	TRA2B1-SRSF9-SRSF6 complex	Human	TRA2B1-SRP30C-SRP55 complex	HeLa cells	P62995;Q13242;Q13247	None;None;None	MI:0019-coimmunoprecipitation	GO:0043484;GO:0048024	regulation of RNA splicing;regulation of mRNA splicing, via spliceosome	11.04.03.01.10	regulation of splicing	15695522	Tau (Mapt) exons 2 and 10, which are misregulated in neurodegenerative diseases, are partly regulated by silencers which bind a SRp30c-SRp55 complex that either recruits or antagonizes htra2beta1. SRp30c is also known as SRSF9, and SRp55 as SRSF6. To confirm the three factors acting as a complex, co-immunoprecipitations of the three proteins were done. It could be shown that htra2beta1 (a variant of TRA2B) interacts with SRp55 and SRp30c interacts with both SRp55 and htra2beta1.	TAU-mutations that affect exon 10 splicing cause frontotemporal dementia (FTDP). TAU-exon 2 is significantly reduced in myotonic dystrophy type 1, whose symptoms include dementia.	A variant of TRA2B (TRA2B1) was used.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transformer-2 protein homolog beta;Serine/arginine-rich splicing factor 9;Serine/arginine-rich splicing factor 6	TRA2B;SRSF9;SRSF6	SFRS10;SFRS9 SRP30C;SFRS6, SRP55
6073	SRSF9-SRSF6 complex	Human	SRP30C-SRP55 complex	HeLa cells	Q13242;Q13247	None;None	MI:0019-coimmunoprecipitation	GO:0043484;GO:0048024	regulation of RNA splicing;regulation of mRNA splicing, via spliceosome	11.04.03.01.10	regulation of splicing	15695522	Tau exons 2 and 10, which are misregulated in neurodegenerative diseases, are partly regulated by silencers which bind a SRp30c-SRp55 complex that either recruits or antagonizes htra2beta1 (a variant of TRA2B).	TAU-mutations that affect exon 10 splicing cause frontotemporal dementia (FTDP). TAU-exon 2 is significantly reduced in myotonic dystrophy type 1, whose symptoms include dementia.	None	Homo sapiens (Human);Homo sapiens (Human)	Serine/arginine-rich splicing factor 9;Serine/arginine-rich splicing factor 6	SRSF9;SRSF6	SFRS9 SRP30C;SFRS6, SRP55
6075	CST complex	Human	None	None	Q2NKJ3;Q86WV5;Q9H668	80169;100134934;79991	MI:0018-two hybrid;MI:0019-coimmunoprecipitation	GO:0003697;GO:0000723	single-stranded DNA binding;telomere maintenance	None	None	19854130	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	CST complex subunit CTC1;CST complex subunit TEN1;CST complex subunit STN1	CTC1;TEN1;STN1	C17orf68;C17orf106;OBFC1
6076	c-Abl-cortactin-nmMLCK complex	Human	None	Human pulmonary artery endothelial cells (HPAEC)	P00519;Q14247;Q15746	25;2017;4638	MI:0019-coimmunoprecipitation	GO:0007010;GO:0061028	cytoskeleton organization;establishment of endothelial barrier	42.04	cytoskeleton/structural proteins	20861316	The association of c-Abl, nmMLCK (nonmuscle), and cortactin is increased in ECs (endothelial cells) during S1P (sphingosine 1-phosphate) ,induced barrier enhancement.	nmMLCK plays a role in inflammatory processes, several polymorphisms in the nmMLCK gene (MYLK) are highly associated with susceptibility to acute inflammatory states such as acute lung injury/acute respiratory distress syndrome (ALI/ARDS) and asthma.	MYLK has been defined as non-muscle isoform, nmMYLK.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Tyrosine-protein kinase ABL1;Src substrate cortactin;Myosin light chain kinase, smooth muscle	ABL1;CTTN;MYLK	ABL, JTK7;EMS1;MLCK MLCK1 MYLK1
6078	ACR-HSPA2-PDIA6 complex	Human	None	testis	P12821;P54652;Q15084	1636;3306;10130	MI:0019-coimmunoprecipitation	GO:0060046	regulation of acrosome reaction	None	None	26676989	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Angiotensin-converting enzyme;Heat shock-related 70 kDa protein 2;Protein disulfide-isomerase A6	ACE;HSPA2;PDIA6	DCP DCP1;None;ERP5 P5 TXNDC7
6079	BAG6-HSPA2 complex	Human	None	spermatozoa	P46379;P54652	7917;3306	MI:0019-coimmunoprecipitation	GO:0007283;GO:1903332	spermatogenesis;regulation of protein folding	None	None	26153132	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Large proline-rich protein BAG6;Heat shock-related 70 kDa protein 2	BAG6;HSPA2	BAT3 G3;None
6080	ACAP1-CLTC-SLC2A4 complex	Human	ACAP1-CHC-Glut4 complex	differentiated 3T3-L1 cells	P14672;Q00610;Q15027	6517;1213;9744	MI:0019-coimmunoprecipitation	GO:0032456	endocytic recycling	None	None	17664335	The results suggested that ACAP1 acted like AP adaptors in bridging an interaction between cargo tails and clathrin triskelion.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Solute carrier family 2, facilitated glucose transporter member 4;Clathrin heavy chain 1;Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1	SLC2A4;CLTC;ACAP1	GLUT4;CLH17 CLTCL2 KIAA0034;CENTB1 KIAA0050
6083	CART complex	Human	Cytoskeleton-associated recycling or transport complex	HeLa cells	O14964;O43707;O75382;Q9ULV0	9146;81;10612;4645	MI:0019-coimmunoprecipitation	GO:0004998;GO:0001881;GO:0032456	transferrin receptor activity;receptor recycling;endocytic recycling	None	None	15772161	The CART complex is necessary for efficient recycling of the transferrin (Tf) receptor to the plasma membrane, but not movement to lysosomes and degradation of the EGFR.The CART complex, composed of hrs, actinin-4, BERP, and myosin V, seemed to require BERP to link myosin V to hrs-actinin-4.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Hepatocyte growth factor-regulated tyrosine kinase substrate;Alpha-actinin-4;Tripartite motif-containing protein 3;Unconventional myosin-Vb	HGS;ACTN4;TRIM3;MYO5B	HRS;None;BERP, RNF22, RNF97;KIAA1119
6084	AFF4 super elongation complex (SEC)	Human	None	293 Flp-in-TRex cells	O00472;O60563;O60583;P42568;P50750;P51825;P55199;Q03111;Q96JC9;Q9HB65;Q9UHB7	22936;904;905;4300;1025;4299;8178;4298;85403;80237;27125	MI:0004-affinity chromatography technology;MI:0019-coimmunoprecipitation;MI:0071-molecular sieving	GO:0006354	DNA-templated transcription elongation	11.02.03.01.04	transcription elongation	20159561	AFF4 is a central factor required for the assembly and integrity of the ELL/P-TEFb (consisting of Cdk9 with cyclin T1, T2a orT2b)/MLL partner elongation complex.	The authors propose that the AFF4 super elongation complex (SEC) could be a key regulator in the pathogenesis of leukemia through many of the MLL (Mixed Lineage Leukemia) partners are found in hematological malignancies.	Complex subunit Cyclin-T2  is described as isoform Cyclin-T2a or Cyclin-T2b.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	RNA polymerase II elongation factor ELL2;Cyclin-T1;Cyclin-T2;Protein AF-9;Cyclin-dependent kinase 9;AF4/FMR2 family member 1;RNA polymerase II elongation factor ELL;Protein ENL;ELL-associated factor 1;RNA polymerase II elongation factor ELL3;AF4/FMR2 family member 4	ELL2;CCNT1;CCNT2;MLLT3;CDK9;AFF1;ELL;MLLT1;EAF1;ELL3;AFF4	None;None;None;AF9 YEATS3;CDC2L4 TAK;AF4 FEL MLLT2 PBM1;C19orf17;ENL LTG19 YEATS1;None;None;AF5Q31 MCEF
6085	MCPIP1-MCPIP4 complex	Human	None	HEK-293 cells	A2A288;Q5D1E8	340152;80149	MI:0018-two hybrid;MI:0019-coimmunoprecipitation;MI:0069-mass spectrometry studies of complexes	GO:0006954	inflammatory response	36.25.16.07	inflammatory response	26134560	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Probable ribonuclease ZC3H12D;Endoribonuclease ZC3H12A	ZC3H12D;ZC3H12A	C6orf95 MCPIP4 TFL;MCPIP MCPIP1
6087	ERbeta-AR complex	Human	None	Prostate cancer cells	P10275;Q92731	367;2100	MI:0019-coimmunoprecipitation	GO:0006355	regulation of DNA-templated transcription	11.02.03.04	transcriptional control	26015225	17beta-estradiol (E2) up-regulates SOX4 expression in the absence of androgen through the formation of a protein complex between ERbeta (estrogen beta receptor) and AR (androgen receptor). Knockdown of AR or ERbeta blocks the E2-induced SOX4 expression. ChIP assays confirmed that both ERbeta and AR bind to the SOX4 promoter in response to E2. E2 could promote proliferation of PCa cells through the up-regulation of SOX4 under androgen-depleted environment (PMID:26015225).	OMIM:176807 Prostate cancer	None	Homo sapiens (Human);Homo sapiens (Human)	Androgen receptor;Estrogen receptor beta	AR;ESR2	DHTR, NR3C4;ESTRB NR3A2
6088	Seipin-AGPAT2 complex	Human	AGPAT2-BSCL2 complex	HEK293 cells	O15120;Q96G97	10555;26580	MI:0019-coimmunoprecipitation	GO:1904177;GO:0008610	regulation of adipose tissue development;lipid biosynthetic process	01.06	lipid, fatty acid and isoprenoid metabolism	25737955	The seipin can bind AGPAT2 during adipogenesis and this interaction during adipogenesis can increase the nuclear accumulation of PPARgamma (PMID:25737955).	None	None	Homo sapiens (Human);Homo sapiens (Human)	1-acyl-sn-glycerol-3-phosphate acyltransferase beta;Seipin	AGPAT2;BSCL2	None;None
6089	Seipin-AGPAT2-lipin1 complex	Human	BSCL2-AGPAT2-LPIN1 complex	HEK293 cells	O15120;Q14693;Q96G97	10555;23175;26580	MI:0428-imaging technique	GO:1904177;GO:0008610	regulation of adipose tissue development;lipid biosynthetic process	01.06	lipid, fatty acid and isoprenoid metabolism	25737955	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	1-acyl-sn-glycerol-3-phosphate acyltransferase beta;Phosphatidate phosphatase LPIN1;Seipin	AGPAT2;LPIN1;BSCL2	None;KIAA0188;None
6090	Seipin-lipin1 complex	Human	BSCL2-LPIN1 complex	HEK293 cells	Q14693;Q96G97	23175;26580	MI:0019-coimmunoprecipitation	None	None	None	None	25737955	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Phosphatidate phosphatase LPIN1;Seipin	LPIN1;BSCL2	KIAA0188;None
6091	NF-YA-LaminA complex	Human	NFYA-LMNA complex	SKBR3 cells	P02545;P23511	4000;4800	MI:0069-mass spectrometry studies of complexes	GO:0007049;GO:0008283	cell cycle;cell population proliferation	10.03	cell cycle	27793050	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Prelamin-A/C;Nuclear transcription factor Y subunit alpha	LMNA;NFYA	LMN1;None
6092	c-Jun-ATF3 complex	Human	JUN-ATF3 complex	MDA-MB-231 cells	P05412;P18847	3725;467	MI:0019-coimmunoprecipitation	GO:0006355	regulation of DNA-templated transcription	11.02.03.04	transcriptional control	27751807	None	OMIM:114480 Breast cancer	None	Homo sapiens (Human);Homo sapiens (Human)	Transcription factor Jun;Cyclic AMP-dependent transcription factor ATF-3	JUN;ATF3	None;None
6095	PLEKHA7-PDZD11 complex	Human	MDCK cells	None	Q5EBL8;Q6IQ23	51248;144100	MI:0018-two hybrid;MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0005912	adherens junction	None	None	27044745	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	PDZ domain-containing protein 11;Pleckstrin homology domain-containing family A member 7	PDZD11;PLEKHA7	AIPP1 PDZK11 PISP;None
6096	alphaB-crystallin-Nav1.5 complex	Human	CRYAB-SCN5A complex	HEK-293 cells	P02511;Q14524	1410;6331	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:1905150;GO:0031396	regulation of voltage-gated sodium channel activity;regulation of protein ubiquitination	None	None	26961874	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Alpha-crystallin B chain;Sodium channel protein type 5 subunit alpha	CRYAB;SCN5A	CRYA2 HSPB5;None
6097	MEF2-NR2F2 complex	Human	None	testis	P24468;Q02078	7026;4205	MI:0019-coimmunoprecipitation	GO:0019218	regulation of steroid metabolic process	None	None	26748576	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	COUP transcription factor 2;Myocyte-specific enhancer factor 2A	NR2F2;MEF2A	ARP1 TFCOUP2;MEF2
6103	proMBP-angiotensinogen complex	Human	None	pregnancy serum and plasma	P01019;P13727	183;5553	MI:0071-molecular sieving;MI:0226-ion exchange chromatography	GO:0008217;GO:0007565	regulation of blood pressure;female pregnancy	None	None	7539791	None	The authors suggest that this complex may be involved in the pathophysiology of pregnancies associated with hypertension.	proMBP (MBP) is derived from a preproprotein of 222 amino acids.	Homo sapiens (Human);Homo sapiens (Human)	Angiotensinogen;Bone marrow proteoglycan	AGT;PRG2	SERPINA8;MBP
6104	PAPP-A-proMBP complex	Human	None	pregnancy serum	P13727;Q13219	5553;5069	MI:0226-ion exchange chromatography	GO:0007565	female pregnancy	None	None	7539791	The serum levels of proMBP exceeds that of PAPP-A by several fold on a molar basis, and consequently, only a fraction of circulating proMBP is bound to PAPP-A.	None	proMBP (MBP) is derived from a preproprotein of 222 amino acids.	Homo sapiens (Human);Homo sapiens (Human)	Bone marrow proteoglycan;Pappalysin-1	PRG2;PAPPA	MBP;None
6107	proMBP-angiotensinogen-c3dg complex	Human	None	pregnancy serum and plasma	P01019;P01024;P13727	183;718;5553	MI:0004-affinity chromatography technology	GO:0008217;GO:0007565	regulation of blood pressure;female pregnancy	None	None	7539791	None	The authors suggest that this complex may be involved in the pathophysiology of pregnancies associated with hypertension.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Angiotensinogen;Complement C3;Bone marrow proteoglycan	AGT;C3;PRG2	SERPINA8;CPAMD1;MBP
6108	STIM1-TRPV4 complex	Human	None	HEK-293 cells	Q13586;Q9HBA0	6786;59341	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0051924	regulation of calcium ion transport	None	None	25972993	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Stromal interaction molecule 1;Transient receptor potential cation channel subfamily V member 4	STIM1;TRPV4	GOK;VRL2, VROAC
6109	FHF complex	Human	None	human embryonic kidney 293T cells	Q86VS8;Q8N612;Q96ED9;Q9H8T0;Q9UJC3	84376;84067;29911;64400;51361	MI:0071-molecular sieving	GO:0016192;GO:0006906;GO:0016197	vesicle-mediated transport;vesicle fusion;endosomal transport	20.09.07;20.09.07.27	vesicular transport (Golgi network, etc.);vesicle fusion	18799622	Hook proteins as well as FTS interact with members of both the class B and class C components of the homotypic vesicular protein sorting (HOPS) complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein Hook homolog 3;FHF complex subunit HOOK interacting protein 1B;Protein Hook homolog 2;AKT-interacting protein;Protein Hook homolog 1	HOOK3;FHIP1B;HOOK2;AKTIP;HOOK1	None;C11orf56 FAM160A2 KIAA1759;None;FTS;None
6111	protein phosphatase 2A C-subunit-synapsin complex	Human	None	None	P17600;P67775	6853;5515	MI:0019-coimmunoprecipitation	GO:0050804	modulation of chemical synaptic transmission	None	None	25522393	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Synapsin-1;Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	SYN1;PPP2CA	None;None
6112	DGAT2-MGAT2 complex	Human	None	HEK-293 cells	Q10469;Q96PD7	4247;84649	MI:0019-coimmunoprecipitation;MI:0030-cross-linking study	GO:0019432	triglyceride biosynthetic process	None	None	25164810	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase;Diacylglycerol O-acyltransferase 2	MGAT2;DGAT2	None;None
6114	BAG1-HSC70 complex	Human	None	None	P11142;Q99933	3312;573	MI:0004-affinity chromatography technology	GO:0006457	protein folding	14.01	protein folding and stabilization	9305631	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Heat shock cognate 71 kDa protein;BAG family molecular chaperone regulator 1	HSPA8;BAG1	HSC70 HSP73 HSPA10;HAP
6115	BAG1-HSP70 complex	Human	None	None	P0DMV8;Q99933	3303;573	MI:0004-affinity chromatography technology	GO:0006457	protein folding	14.01	protein folding and stabilization	9305631	None	None	Since the authors did not specify HSP70, we used isoform HSPA1A.	Homo sapiens (Human);Homo sapiens (Human)	Heat shock 70 kDa protein 1A;BAG family molecular chaperone regulator 1	HSPA1A;BAG1	HSP72 HSPA1 HSX70;HAP
6116	Hook1-Vps16 complex	Human	None	human embryonic kidney 293T cells	Q9H269;Q9UJC3	64601;51361	MI:0007-anti tag coimmunoprecipitation	GO:0016197	endosomal transport	None	None	18799622	FTS and Hook proteins associate with class B and class C components of the HOPS complex.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Vacuolar protein sorting-associated protein 16 homolog;Protein Hook homolog 1	VPS16;HOOK1	None;None
6117	Hook1-Vps18 complex	Human	None	human embryonic kidney 293T cells	Q9P253;Q9UJC3	57617;51361	MI:0007-anti tag coimmunoprecipitation	GO:0016197	endosomal transport	None	None	18799622	FTS and Hook proteins associate with class B and class C components of the HOPS complex.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Vacuolar protein sorting-associated protein 18 homolog;Protein Hook homolog 1	VPS18;HOOK1	KIAA1475;None
6118	Hook1-Vps39 complex	Human	None	human embryonic kidney 293T cells	Q96JC1;Q9UJC3	23339;51361	MI:0007-anti tag coimmunoprecipitation	GO:0016197	endosomal transport	None	None	18799622	FTS and Hook proteins associate with class B and class C components of the HOPS complex.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Vam6/Vps39-like protein;Protein Hook homolog 1	VPS39;HOOK1	KIAA0770 TLP VAM6;None
6119	Hook1-Vps41 complex	Human	None	human embryonic kidney 293T cells	P49754;Q9UJC3	27072;51361	MI:0007-anti tag coimmunoprecipitation	GO:0016197	endosomal transport	None	None	18799622	FTS and Hook proteins associate with class B and class C components of the HOPS complex.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Vacuolar protein sorting-associated protein 41 homolog;Protein Hook homolog 1	VPS41;HOOK1	None;None
6120	Hook2-Vps16 complex	Human	None	human embryonic kidney 293T cells	Q96ED9;Q9H269	29911;64601	MI:0007-anti tag coimmunoprecipitation	GO:0016197	endosomal transport	None	None	18799622	FTS and Hook proteins associate with class B and class C components of the HOPS complex.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Protein Hook homolog 2;Vacuolar protein sorting-associated protein 16 homolog	HOOK2;VPS16	None;None
6121	Hook2-Vps41 complex	Human	None	human embryonic kidney 293T cells	P49754;Q96ED9	27072;29911	MI:0007-anti tag coimmunoprecipitation	GO:0016197	endosomal transport	None	None	18799622	FTS and Hook proteins associate with class B and class C components of the HOPS complex.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Vacuolar protein sorting-associated protein 41 homolog;Protein Hook homolog 2	VPS41;HOOK2	None;None
6122	Hook3-Vps16 complex	Human	None	human embryonic kidney 293T cells	Q86VS8;Q9H269	84376;64601	MI:0007-anti tag coimmunoprecipitation	GO:0016197	endosomal transport	None	None	18799622	FTS and Hook proteins associate with class B and class C components of the HOPS complex.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Protein Hook homolog 3;Vacuolar protein sorting-associated protein 16 homolog	HOOK3;VPS16	None;None
6123	Hook3-Vps41 complex	Human	None	human embryonic kidney 293T cells	P49754;Q86VS8	27072;84376	MI:0007-anti tag coimmunoprecipitation	GO:0016197	endosomal transport	None	None	18799622	FTS and Hook proteins associate with class B and class C components of the HOPS complex.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Vacuolar protein sorting-associated protein 41 homolog;Protein Hook homolog 3	VPS41;HOOK3	None;None
6124	FTS-Vps16 complex	Human	None	human embryonic kidney 293T cells	Q9H269;Q9H8T0	64601;64400	MI:0007-anti tag coimmunoprecipitation	GO:0016197	endosomal transport	None	None	18799622	FTS and Hook proteins associate with class B and class C components of the HOPS complex.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Vacuolar protein sorting-associated protein 16 homolog;AKT-interacting protein	VPS16;AKTIP	None;FTS
6125	FTS-Vps18 complex	Human	None	human embryonic kidney 293T cells	Q9H8T0;Q9P253	64400;57617	MI:0007-anti tag coimmunoprecipitation	GO:0016197	endosomal transport	None	None	18799622	FTS and Hook proteins associate with class B and class C components of the HOPS complex.	None	None	Homo sapiens (Human);Homo sapiens (Human)	AKT-interacting protein;Vacuolar protein sorting-associated protein 18 homolog	AKTIP;VPS18	FTS;KIAA1475
6126	FTS-Vps41 complex	Human	None	human embryonic kidney 293T cells	P49754;Q9H8T0	27072;64400	MI:0007-anti tag coimmunoprecipitation	GO:0016197	endosomal transport	None	None	18799622	FTS and Hook proteins associate with class B and class C components of the HOPS complex.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Vacuolar protein sorting-associated protein 41 homolog;AKT-interacting protein	VPS41;AKTIP	None;FTS
6127	DAXX-MDM2-USP7 complex	Human	None	HCT116 cells	Q00987;Q93009;Q9UER7	4193;7874;1616	MI:0019-coimmunoprecipitation	GO:0061136;GO:0005654;GO:0006281	regulation of proteasomal protein catabolic process;nucleoplasm;DNA repair	10.01.05.01	DNA repair	16845383	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase Mdm2;Ubiquitin carboxyl-terminal hydrolase 7;Death domain-associated protein 6	MDM2;USP7;DAXX	None;HAUSP;BING2 DAP6
6129	CBP80/20- dependent translation complex	Human	CT initiation complex	HeLa cells	O43310;P38919;P52298;P55884;Q09161;Q9BZI7	9811;9775;22916;8662;4686;65109	MI:0019-coimmunoprecipitation;MI:0047-far western blotting;MI:0663-confocal microscopy	GO:0070992;GO:0003743;GO:0048471	translation initiation complex;translation initiation factor activity;perinuclear region of cytoplasm	None	None	19648179	CTIF interacts directly via its MIF4G domain with CBP80, is part of the CBP80/20-dependent translation initiation complex, and is complexed with eIF3 and eIF4AIII. Endogenous CBP80, eIF3b, and NMD factor Upf3X copurified with endogenous CTIF. Depletion of endogenous CTIF from an in vitro translation system selectively blocks the translation of CBP80-bound mRNAs, while addition of purified CTIF restores it.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	CBP80/20-dependent translation initiation factor;Eukaryotic initiation factor 4A-III;Nuclear cap-binding protein subunit 2;Eukaryotic translation initiation factor 3 subunit B;Nuclear cap-binding protein subunit 1;Regulator of nonsense transcripts 3B	CTIF;EIF4A3;NCBP2;EIF3B;NCBP1;UPF3B	KIAA0427;DDX48, KIAA0111;CBP20;EIF3S9;CBP80 NCBP;RENT3B, UPF3X
6131	SELK multiprotein complex	Human	None	HEK-293 cells	P04843;P04844;P27824;P39656;P46977;P55072;Q9BQE4;Q9BUN8;Q9GZP9;Q9Y6D0	6184;6185;821;1650;3703;7415;55829;79139;51009;58515	MI:0007-anti tag coimmunoprecipitation	GO:0030968;GO:0036503	endoplasmic reticulum unfolded protein response;ERAD pathway	32.01.07	unfolded protein response (e.g. ER quality control)	22016385	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1;Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2;Calnexin;Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit;Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A;Transitional endoplasmic reticulum ATPase;Selenoprotein S;Derlin-1;Derlin-2;Selenoprotein K	RPN1;RPN2;CANX;DDOST;STT3A;VCP;SELENOS;DERL1;DERL2;SELENOK	None;None;None;KIAA0115 OST48;ITM1 TMC;None;SELS VIMP;DER1;DER2; FLANA;SELK
6132	MICOS subcomplex (CHCHD3, IMMT, MICOS10), mitochondrial	Human	MICOS subcomplex (MIC10, MIC19, MIC60), mitochondrial; MINOS complex, mitochondrial; MIB subcomplex, mitochondrial	primary fibroblast cells	Q16891;Q5TGZ0;Q9NX63	10989;440574;54927	MI:0040-electron microscopy;MI:0416-fluorescence microscopy	GO:0007007;GO:0061617;GO:0042407	inner mitochondrial membrane organization;MICOS complex;cristae formation	None	None	23676277	MINOS (mitochondrial inner membrane organizing system ) is a Mitofilin-containing protein complex in the inner mitochondrial membrane (IMM) and functions as the major organizer of cristae structure (PMID:25781180).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	MICOS complex subunit MIC60;MICOS complex subunit MIC10;MICOS complex subunit MIC19	IMMT;MICOS10;CHCHD3	HMP MIC60 MINOS2;C1orf151 MIC10 MINOS1;MIC19, MINOS3
6133	RFX5-RFXANK-RFXAP complex	Human	None	None	O00287;O14593;P48382	5994;8625;5993	MI:0030-cross-linking study;MI:0114-x-ray crystallography	GO:0003700	DNA-binding transcription factor activity	None	None	20637319	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Regulatory factor X-associated protein;DNA-binding protein RFXANK;DNA-binding protein RFX5	RFXAP;RFXANK;RFX5	None;ANKRA1 RFXB;None
6134	Rs1 homooctamer complex	Human	None	HEK-293 cells	O15537	6247	MI:0071-molecular sieving	GO:0007601;GO:0010842;GO:0016062;GO:0007155	visual perception;retina layer formation;adaptation of rhodopsin mediated signaling;cell adhesion	34.11.01.03;34.07	visual transduction;cell adhesion	15644328	None	None	None	Homo sapiens (Human)	Retinoschisin	RS1	XLRS1
6135	Ferritin complex	Human	None	None	P02792;P02794	2512;2495	MI:0428-imaging technique	GO:0006879;GO:0006955;GO:0006826	cellular iron ion homeostasis;immune response;iron ion transport	36.25.16	immune response	8695634	None	OMIM:615604  L-ferritin deficiency, OMIM:615517 Hemochromatosis, type 5 (PMID:8695634),	None	Homo sapiens (Human);Homo sapiens (Human)	Ferritin light chain;Ferritin heavy chain	FTL;FTH1	None;FTH FTHL6
6136	USP7-MAGEL2-TRIM27 complex	Human	None	None	P14373;Q93009;Q9UJ55	5987;7874;54551	MI:0019-coimmunoprecipitation	GO:0016197	endosomal transport	None	None	26365382	None	OMIM:209850 Autism (PMID:26365382).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Zinc finger protein RFP;Ubiquitin carboxyl-terminal hydrolase 7;MAGE-like protein 2	TRIM27;USP7;MAGEL2	RFP RNF76;HAUSP;NDNL1
6137	GM-CSF receptor complex	Human	None	erythroleukemic TF-1 cell line	P04141;P15509;P32927	1437;1438;1439	MI:0114-x-ray crystallography	GO:0038158;GO:0004896	granulocyte colony-stimulating factor signaling pathway;cytokine receptor activity	None	None	18692472	Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a pleiotropic cytokine that controls the production and function of blood cells. It is deregulated in clinical conditions such as rheumatoid arthritis and leukemia. Its receptors are heterodimers consisting of a ligand-specific alpha subunit and a beta subunit that is shared with the interleukin (IL)-3 and IL-5 receptors. JAK2 activation is a feature of GM-CSF receptor activation and plays a critical  role in GM-CSF signaling. The structure of the GM-CSF receptor complex reveals a hexameric 2:2:2 assembly, consisting of two beta chains, two GMR alpha chains, and two GM-CSF molecules. The crystal lattice generates an unexpected dodecamer complex, an assembly consisting of two hexameric complexes related by a crystallographic two-fold axis. The dodecamer assembles in a head-to-head orientation. Functional studies reveal that dodecamer formation is required for receptor activation and signaling. This differs from the 2:1:1 stoichiometry  (2 betac,1 GMRalpha,1 GM-CSF) (McClure et al., 2003). This is likely to be a result of differences in the total protein concentration at which the complex is formed as we observe a protein concentration-dependent shift in molecular  weight and hence stoichiometry of GM-CSF receptor complex. The 2:1:1 complex probably represents a relatively stable intermediate in the assembly of higher-order 2:2:2 GM-CSFreceptor complexes.	Abnormalities in GM-CSF production or receptor function have been implicated in multiple pathologies such as rheumatoid arthritis (Cook et al., 2001), juvenile myelomonocytic leukemia (Birnbaum et al., 2000), chronic myelomonocytic leukemia (Ramshaw et al., 2002), and alveolar proteinosis (Dirksen et al., 1998). Furthermore, the GM-CSF receptor may also be important in the pathogenesis of chronic myeloid leukemia and myeloproliferative diseases by propagating survival and proliferation signalspromoted by the abnormal expression of Bcr-Abl and JAK2 mutations, respectively (PMID:18692472).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Granulocyte-macrophage colony-stimulating factor;Granulocyte-macrophage colony-stimulating factor receptor subunit alpha;Cytokine receptor common subunit beta	CSF2;CSF2RA;CSF2RB	GMCSF;CSF2R, CSF2RY;IL3RB, IL5RB
6140	Cdt1-Geminin complex	Human	None	None	O75496;Q9H211	51053;81620	MI:0114-x-ray crystallography	GO:0006275	regulation of DNA replication	None	None	19906994	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Geminin;DNA replication factor Cdt1	GMNN;CDT1	None;None
6141	CSE1L-KPNA2-RAN complex	Human	Importin alpha-CAS-RanGTP complex	HeLa mRNA expressed in E.coli	P52292;P55060;P62826	3838;1434;5901	MI:0051-fluorescence technology;MI:0413-electrophoretic mobility shift assay	GO:0006913;GO:0005634;GO:0015031;GO:0005737;GO:0006611;GO:0055085	nucleocytoplasmic transport;nucleus;protein transport;cytoplasm;protein export from nucleus;transmembrane transport	70.10;20.01.10;70.03	nucleus;protein transport;cytoplasm	9323134	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Importin subunit alpha-1;Exportin-2;GTP-binding nuclear protein Ran	KPNA2;CSE1L;RAN	RCH1, SRP1;CAS XPO2;ARA24
6142	KPNA2-KPNB1 complex	Human	Importin alpha/beta complex	HeLa mRNA expressed in E.coli	P52292;Q14974	3838;3837	MI:0051-fluorescence technology;MI:0413-electrophoretic mobility shift assay	GO:0005634;GO:0005737;GO:0006606	nucleus;cytoplasm;protein import into nucleus	70.10;70.03	nucleus;cytoplasm	9323134	NLS proteins are transported into the nucleus by the importin alpha/beta heterodimer. Importin alpha binds the NLS, while importin beta mediates translocation through the nuclear pore complex. It was shown that without further addition or with addition of wild-type RanGDP, importin beta bound efficiently to importin alpha.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Importin subunit alpha-1;Importin subunit beta-1	KPNA2;KPNB1	RCH1, SRP1;NTF97
6143	KPNB1-RAN complex	Human	Importin beta-RanGTP complex	HeLa mRNA expressed in E.coli	P62826;Q14974	5901;3837	MI:0051-fluorescence technology;MI:0413-electrophoretic mobility shift assay	GO:0006913;GO:0006611;GO:0005634;GO:0005737;GO:0055085	nucleocytoplasmic transport;protein export from nucleus;nucleus;cytoplasm;transmembrane transport	70.10;70.03	nucleus;cytoplasm	9323134	NLS proteins are transported into the nucleus by the importin alpha/beta heterodimer. Importin alpha binds the NLS, while importin beta mediates translocation through the nuclear pore complex. After translocation, RanGTP, whose predicted concentration is high in the nucleus and low in the cytoplasm, binds importin beta disassembling the importin alpha/beta heterodimer.	None	None	Homo sapiens (Human);Homo sapiens (Human)	GTP-binding nuclear protein Ran;Importin subunit beta-1	RAN;KPNB1	ARA24;NTF97
6144	CENP-T-W complex	Human	None	None	Q5EE01;Q96BT3	387103;80152	MI:0071-molecular sieving	GO:0007059;GO:0003677;GO:0051382	chromosome segregation;DNA binding;kinetochore assembly	10.03.04.05;16.03.01;10.03.04.01	chromosome segregation/division;DNA binding;centromere/kinetochore complex maturation	22304917	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Centromere protein W;Centromere protein T	CENPW;CENPT	C6orf173, CUG2;C16orf56, ICEN22
6145	CENP-S-X complex	Human	None	None	A8MT69;Q8N2Z9	201254;378708	MI:0071-molecular sieving	GO:0007059;GO:0003677;GO:0051382	chromosome segregation;DNA binding;kinetochore assembly	10.03.04.05;16.03.01;10.03.04.01	chromosome segregation/division;DNA binding;centromere/kinetochore complex maturation	22304917	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Centromere protein X;Centromere protein S	CENPX;CENPS	FAAP10 MHF2 STRA13;APITD1 FAAP16 MHF1
6146	CENP-T-W-S-X heterotetramer complex	Human	None	None	A8MT69;Q5EE01;Q8N2Z9;Q96BT3	201254;387103;378708;80152	MI:0071-molecular sieving	GO:0051382;GO:0003677;GO:0007059	kinetochore assembly;DNA binding;chromosome segregation	10.03.04.01;16.03.01;10.03.04.05	centromere/kinetochore complex maturation;DNA binding;chromosome segregation/division	22304917	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Centromere protein X;Centromere protein W;Centromere protein S;Centromere protein T	CENPX;CENPW;CENPS;CENPT	FAAP10 MHF2 STRA13;C6orf173, CUG2;APITD1 FAAP16 MHF1;C16orf56, ICEN22
6147	BAFL-BAF-LAP2beta complex	Human	None	HeLa cells	O75531;P42167;Q9H503	8815;7112;140836	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0005634;GO:0006325	nucleus;chromatin organization	70.10	nucleus	16337940	BAF-L forms ternary complexes in vitro with BAF and LAP2beta through heterodimerization with BAF.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Barrier-to-autointegration factor;Lamina-associated polypeptide 2, isoforms beta/gamma;Barrier-to-autointegration factor-like protein	BANF1;TMPO;BANF2	BAF BCRG1;LAP2;BAFL C20orf179
6148	BAFL-BAF complex	Human	None	HeLa cells	O75531;Q9H503	8815;140836	MI:0019-coimmunoprecipitation	GO:0005634;GO:0006325	nucleus;chromatin organization	70.10	nucleus	16337940	BAF-L regulates BAF function via heterodimerization and might thereby influence tissue-specific roles of BAF.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Barrier-to-autointegration factor;Barrier-to-autointegration factor-like protein	BANF1;BANF2	BAF BCRG1;BAFL C20orf179
6149	Codanin-1-Asf1\u2013histone H3.1-histone H4\u2013importin-4 complex,  cytosolic	Human	None	HeLa S3 cells	P62805;P68431;Q8IWY9;Q8TEX9;Q9Y294	None;None;146059;79711;25842	MI:0019-coimmunoprecipitation;MI:0071-molecular sieving	GO:0006260;GO:0017038;GO:0006325	DNA replication;protein import;chromatin organization	10.01.03	DNA synthesis and replication	22407294	None	Mutations in Codanin-1 can cause congenital dyserythropoietic anaemia type I (CDAI), characterized by chromatin abnormalities in bone marrow erythroblasts.	Codanin-1 seems to guard a limiting step in chromatin replication.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone H4;Histone H3.1;Codanin-1;Importin-4;Histone chaperone ASF1A	H4C1;H3C1;CDAN1;IPO4;ASF1A	H4/A H4FA HIST1H4A;H3FA,HIST1H3A;None;IMP4B, RANBP4;None
6153	PRKAA2-PRKAB2-PRKAG3 complex	Human	AMPK alpha2-beta2-gamma3 complex	skeletal muscle cells	O43741;P54646;Q9UGI9	5565;5563;53632	MI:0019-coimmunoprecipitation	GO:0004679;GO:0043501	AMP-activated protein kinase activity;skeletal muscle adaptation	None	None	17038425	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	5'-AMP-activated protein kinase subunit beta-2;5'-AMP-activated protein kinase catalytic subunit alpha-2;5'-AMP-activated protein kinase subunit gamma-3	PRKAB2;PRKAA2;PRKAG3	None;AMPK AMPK2;AMPKG3
6154	PRKAA1-PRKAB2-PRKAG1 complex	Human	AMPK alpha1-beta2-gamma1 complex, skeletal muscle	skeletal muscle cells	O43741;P54619;Q13131	5565;5571;5562	MI:0019-coimmunoprecipitation	GO:0004679	AMP-activated protein kinase activity	None	None	17038425	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	5'-AMP-activated protein kinase subunit beta-2;5'-AMP-activated protein kinase subunit gamma-1;5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAB2;PRKAG1;PRKAA1	None;None;AMPK1
6155	PRKAA2-PRKAB2-PRKAG1 complex	Human	AMPK alpha2-beta2-gamma1 complex, skeletal muscle	skeletal muscle cells	O43741;P54619;P54646	5565;5571;5563	MI:0019-coimmunoprecipitation	GO:0004679;GO:0043501	AMP-activated protein kinase activity;skeletal muscle adaptation	None	None	17038425	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	5'-AMP-activated protein kinase subunit beta-2;5'-AMP-activated protein kinase subunit gamma-1;5'-AMP-activated protein kinase catalytic subunit alpha-2	PRKAB2;PRKAG1;PRKAA2	None;None;AMPK AMPK2
6158	TRIAL-DR5 complex	Human	TNFSF10-TNFRSF10B complex	MCF-10A cells	O14763;P50591	8795;8743	MI:0019-coimmunoprecipitation	GO:0006915	apoptotic process	40.10.02	apoptosis (type I programmed cell death)	27542249	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Tumor necrosis factor receptor superfamily member 10B;Tumor necrosis factor ligand superfamily member 10	TNFRSF10B;TNFSF10	DR5 KILLER TRAILR2 TRICK2 ZTNFR9;APO2L TRAIL
6159	LPP-PPP2CA-PPP2R3A complex	Human	None	None	P67775;Q06190;Q93052	5515;5523;4026	MI:0018-two hybrid;MI:0019-coimmunoprecipitation	GO:0005925	focal adhesion	None	None	26945059	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform;Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha;Lipoma-preferred partner	PPP2CA;PPP2R3A;LPP	None;PPP2R3;None
6160	hTREX84 complex	Human	None	HeLa cells	Q13769;Q6I9Y2;Q86W42-2;Q8NI27;Q96FV9;Q96J01	8563;80145;79228;57187;9984;84321	MI:0004-affinity chromatography technology	GO:0006406	mRNA export from nucleus	None	None	15833825	None	hTREX84 is highly expressed in aggressive forms of breast cancer.	hTREX40 resembles isoform 2 of THOC6 which lacks the N-terminal 24 amino acids of the canonical sequence.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	THO complex subunit 5 homolog;THO complex subunit 7 homolog;Isoform 2 of THO complex subunit 6 homolog;THO complex subunit 2;THO complex subunit 1;THO complex subunit 3	THOC5;THOC7;THOC6;THOC2;THOC1;THOC3	C22orf19, KIAA0983;NIF3L1BP1;WDR58;CXorf3;HPR1;None
6163	BBSome	Human	None	HEK-293T cells	A8MTZ0;Q3SYG4;Q8IWZ6;Q8N3I7;Q8NFJ9;Q8TAM2;Q96RK4;Q9BXC9	92482;27241;55212;129880;582;123016;585;583	MI:0019-coimmunoprecipitation;MI:0416-fluorescence microscopy	GO:0044782;GO:0042073;GO:0005929;GO:0060271;GO:0060170;GO:0097733;GO:0007601	cilium organization;intraciliary transport;cilium;cilium assembly;ciliary membrane;photoreceptor cell cilium;visual perception	34.11.01.03	visual transduction	25964651	Rod and cone photoreceptor cells are modified ciliated cells responsible for the night and day vision. The main protein of rod cells is rhodopsin. The transport of this protein from the inside to the outside of rod cells is allowed by BBSome complex. Mutations in BBSome genes lead to mislocalization and accumulation of rhodopsin in rod cells. In this way the cellular homeostasis is disturbed and the degeneration of the photoreceptors is produced (PMID: 34573333).	All the BBS proteins were identified by mutations of their respective genes in patients with Bardet\u2013Biedl syndrome (BBS), a genetically heterogeneous disease (ciliopathy) characterized by a wide spectrum of clinical features, including rod\u2013cone dystrophy, morbid obesity, polydactyly, genital anomalies, learning difficulties, and renal anomalies.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	BBSome-interacting protein 1;Protein PTHB1;Bardet-Biedl syndrome 7 protein;Bardet-Biedl syndrome 5 protein;Bardet-Biedl syndrome 1 protein;Tetratricopeptide repeat protein 8;Bardet-Biedl syndrome 4 protein;Bardet-Biedl syndrome 2 protein	BBIP1;BBS9;BBS7;BBS5;BBS1;TTC8;BBS4;BBS2	BBIP10, NCRNA00081;PTHB1;BBS2L1;None;BBS2L2;BBS8;None;None
6164	ACK1 signaling complex	Human	CDC42-ACK1-p130Cas-CRK collagen-regulated signaling complex	T47D cells	P46108;P56945;P60953;Q07912	1398;9564;998;10188	MI:0019-coimmunoprecipitation	GO:0023052	signaling	30.01	cellular signalling	17038317	CDC42, ACK1, p130Cas, and CRK form a collagen-regulated signaling complex. The interaction of Ack1 and p130Cas relies on SH3 and Proline-rich domains. ACK1 not only associated with p130Casbut also induced its phosphorylation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Adapter molecule crk;Breast cancer anti-estrogen resistance protein 1;Cell division control protein 42 homolog;Activated CDC42 kinase 1	CRK;BCAR1;CDC42;TNK2	None;CAS CASS1 CRKAS;None;ACK1
6165	BBSome core complex	Human	None	HEK-293T cells	Q3SYG4;Q8IWZ6;Q8NFJ9;Q9BXC9	27241;55212;582;583	MI:0019-coimmunoprecipitation;MI:0416-fluorescence microscopy	GO:0005929	cilium	None	None	25964651	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein PTHB1;Bardet-Biedl syndrome 7 protein;Bardet-Biedl syndrome 1 protein;Bardet-Biedl syndrome 2 protein	BBS9;BBS7;BBS1;BBS2	PTHB1;BBS2L1;BBS2L2;None
6166	BBSome linker complex	Human	None	HEK-293T cells	A8MTZ0;Q8TAM2;Q96RK4	92482;123016;585	MI:0019-coimmunoprecipitation;MI:0416-fluorescence microscopy	GO:0005929	cilium	None	None	25964651	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	BBSome-interacting protein 1;Tetratricopeptide repeat protein 8;Bardet-Biedl syndrome 4 protein	BBIP1;TTC8;BBS4	BBIP10, NCRNA00081;BBS8;None
6167	Exocyst complex	Human	None	HEK-293T cells	O00471;O60645;Q8IYI6;Q8TAG9;Q96A65;Q96KP1;Q9NV70;Q9UPT5	10640;11336;149371;54536;60412;55770;55763;23265	MI:0019-coimmunoprecipitation;MI:0416-fluorescence microscopy	GO:0099022;GO:0006887;GO:0060271	vesicle tethering;exocytosis;cilium assembly	20.09.16.09.03	exocytosis	25964651	The exocyst complex regulates tethering of transferrin-receptor-containing recycling vesicles to the plasma membrane, downstream of the Rab11 small GTPase.	Exocyst levels are higher in patients with autosomal dominant polycystic kidney disease (PMID: 28624967).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Exocyst complex component 5;Exocyst complex component 3;Exocyst complex component 8;Exocyst complex component 6;Exocyst complex component 4;Exocyst complex component 2;Exocyst complex component 1;Exocyst complex component 7	EXOC5;EXOC3;EXOC8;EXOC6;EXOC4;EXOC2;EXOC1;EXOC7	SEC10 SEC10L1;SEC6 SEC6L1;None;SEC15A SEC15L SEC15L1;KIAA1699 SEC8 SEC8L1;SEC5 SEC5L1;SEC3 SEC3L1;EXO70 KIAA1067
6168	Exocyst EXOC5-EXOC6 subcomplex	Human	Exocyst sec10-sec15 subcomplex	HEK-293T cells	O00471;Q8TAG9	10640;54536	MI:0019-coimmunoprecipitation;MI:0416-fluorescence microscopy	GO:0006887	exocytosis	20.09.16.09.03	exocytosis	25964651	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Exocyst complex component 5;Exocyst complex component 6	EXOC5;EXOC6	SEC10 SEC10L1;SEC15A SEC15L SEC15L1
6169	Exocyst EXOC5-EXOC6-EXOC7 subcomplex	Human	Exocyst sec10-sec15-exo70  subcomplex	HEK-293T cells	O00471;Q8TAG9;Q9UPT5	10640;54536;23265	MI:0019-coimmunoprecipitation;MI:0416-fluorescence microscopy	GO:0006887	exocytosis	20.09.16.09.03	exocytosis	25964651	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Exocyst complex component 5;Exocyst complex component 6;Exocyst complex component 7	EXOC5;EXOC6;EXOC7	SEC10 SEC10L1;SEC15A SEC15L SEC15L1;EXO70 KIAA1067
6170	Angiogenin-PRI complex	Human	None	None	P03950;P13489	283;6050	MI:0226-ion exchange chromatography	GO:0045765	regulation of angiogenesis	None	None	3470787	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Angiogenin;Ribonuclease inhibitor	ANG;RNH1	RNASE5;PRI, RNH
6173	Intraflagellar transport complex B core complex	Human	IFT-B core complex	HEK293T cells	A0AVF1;Q13099;Q8N4P2;Q8WYA0;Q96LB3;Q9BW83;Q9H7X7;Q9NQC8;Q9Y366;Q9Y547	79989;8100;150737;28981;80173;11020;64792;56912;51098;51668	MI:0019-coimmunoprecipitation;MI:0416-fluorescence microscopy	GO:0005929;GO:0042073	cilium;intraciliary transport	None	None	26980730	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Intraflagellar transport protein 56;Intraflagellar transport protein 88 homolog;Tetratricopeptide repeat protein 30B;Intraflagellar transport protein 81 homolog;Intraflagellar transport protein 74 homolog;Intraflagellar transport protein 27 homolog;Intraflagellar transport protein 22 homolog;Intraflagellar transport protein 46 homolog;Intraflagellar transport protein 52 homolog;Intraflagellar transport protein 25 homolog	TTC26;IFT88;TTC30B;IFT81;IFT74;IFT27;IFT22;IFT46;IFT52;HSPB11	IFT56;TG737 TTC10;None;CDV1;CCDC2 CMG1;RABL4 RAYL;RABL5;C11orf2 C11orf60;C20orf9 NGD5;C1orf41 IFT25
6175	Caspase-10-SUMO-FADD/Drp1 complex	Human	CASP10-FADD-DNM1L complex	HeLa cells	O00429;Q13158;Q92851	10059;8772;843	MI:0019-coimmunoprecipitation	GO:0070266;GO:0005739	necroptotic process;mitochondrion	70.16	mitochondrion	27799292	None	Disease: ischemic injury	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Dynamin-1-like protein;FAS-associated death domain protein;Caspase-10	DNM1L;FADD;CASP10	DLP1 DRP1;MORT1;MCH4
6176	CDCP1-Src-EGFR complex	Human	None	MDA-MB-468 cells	P00533;P12931;Q9H5V8	1956;6714;64866	MI:0004-affinity chromatography technology;MI:0019-coimmunoprecipitation	GO:0007173	epidermal growth factor receptor signaling pathway	30.05.01.12.01	EGF-receptor signalling pathway	27495374	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Epidermal growth factor receptor;Proto-oncogene tyrosine-protein kinase Src;CUB domain-containing protein 1	EGFR;SRC;CDCP1	ERBB ERBB1 HER1;SRC1;TRASK
6178	LUBAC complex	Human	SHARPIN-HOIL1L-HOIP complex;  Linear ubiquitin chain assembly complex; Ubiquitin ligase E3 LUBAC	HEK293T cells; Jurkat cells	Q96EP0;Q9BYM8;Q9H0F6	55072;10616;81858	MI:0019-coimmunoprecipitation;MI:0071-molecular sieving	GO:0050727;GO:0043122;GO:0010941;GO:0097039;GO:0032434;GO:0039535;GO:0045087	regulation of inflammatory response;regulation of I-kappaB kinase/NF-kappaB signaling;regulation of cell death;protein linear polyubiquitination;regulation of proteasomal ubiquitin-dependent protein catabolic process;regulation of RIG-I signaling pathway;innate immune response	36.25.16.01	innate immune response (invertebrates and vertebrates)	21455180	LUBAC complex binds to NEMO (IKBKG ) in the IKK complex, and assembles linear polyubiquitin chains (so-called M1-linked ubiquitin chains) on NEMO. The activated IKK complex subsequently induces the degradation of NFKBIA resulting in activation of NF-kappaB complex. (PMID:26670046). Recruitment of the LUBAC complex to the TNFR1 signaling complex (complex-I) enables full gene-activation whilst preventing cell death (PMID: 20005846)	Null mutations in the Sharpin gene are responsible for chronic proliferative dermatitis in mice.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase RNF31;RanBP-type and C3HC4-type zinc finger-containing protein 1;Sharpin	RNF31;RBCK1;SHARPIN	ZIBRA;C20orf18 RNF54 UBCE7IP3 XAP3 XAP4;SIPL1
6180	PPP2R1A-PPP2R3B complex	Human	None	None	P30153;Q9Y5P8	5518;28227	MI:0071-molecular sieving;MI:0114-x-ray crystallography	GO:0006470	protein dephosphorylation	14.07.03	modification by phosphorylation, dephosphorylation, autophosphorylation	25007185	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform;Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta	PPP2R1A;PPP2R3B	None;PPP2R3L
6182	PP2A A/C-striatin complex	Human	None	transfected NIH 3T3 cells	O43815;P30153;P67775	6801;5518;5515	MI:0019-coimmunoprecipitation	GO:0006470;GO:0019722	protein dephosphorylation;calcium-mediated signaling	14.07.03;30.01.09.03	modification by phosphorylation, dephosphorylation, autophosphorylation;Ca2+ mediated signal transduction	10681496	None	None	Since the authors did not specify serine/threonine-protein phosphatase 2A catalytic subunit we used the alpha isoform. Since the authors did not specify serine/threonine-protein phosphatase 2A regulartory subunit we used the alpha isoform.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Striatin;Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform;Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	STRN;PPP2R1A;PPP2CA	None;None;None
6183	PP2A A/C-SG2NA complex	Human	None	transfected NIH 3T3 cells	P30153;P67775;Q13033	5518;5515;29966	MI:0019-coimmunoprecipitation	GO:0006470;GO:0019722	protein dephosphorylation;calcium-mediated signaling	14.07.03;30.01.09.03	modification by phosphorylation, dephosphorylation, autophosphorylation;Ca2+ mediated signal transduction	10681496	None	None	Since the authors did not specify serine/threonine-protein phosphatase 2A catalytic subunit we used the alpha isoform. Since the authors did not specify serine/threonine-protein phosphatase 2A regulartory subunit we used the alpha isoform.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform;Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform;Striatin-3	PPP2R1A;PPP2CA;STRN3	None;None;GS2NA, SG2NA
6184	AuroraB-AuroraC-INCENP complex	Human	None	PC3 cells	O14965;Q96GD4;Q9NQS7	6790;9212;3619	MI:0019-coimmunoprecipitation;MI:0027-cosedimentation;MI:0416-fluorescence microscopy	GO:0050821	protein stabilization	14.01	protein folding and stabilization	27332895	None	Prostate cancer	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Aurora kinase A;Aurora kinase B;Inner centromere protein	AURKA;AURKB;INCENP	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6;AIK2 AIM1 AIRK2 ARK2 STK1 STK12 STK5;None
6185	GNAI1-GPSM2-SAPCD2 complex	Human	SAPCD2-Galphai-LGN complex	HEK-293T cells	P63096;P81274;Q86UD0	2770;29899;89958	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0000132;GO:0008356	establishment of mitotic spindle orientation;asymmetric cell division	None	None	26766442	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(i) subunit alpha-1;G-protein-signaling modulator 2;Suppressor APC domain-containing protein 2	GNAI1;GPSM2;SAPCD2	None;LGN;C9orf140
6186	ArPIKfyve-Sac3-Sph1 complex	Human	None	HEK-293 cells	Q92562;Q9Y2I7;Q9Y6H5	9896;200576;9627	MI:0019-coimmunoprecipitation;MI:0416-fluorescence microscopy	GO:0050821	protein stabilization	14.01	protein folding and stabilization	26405034	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Polyphosphoinositide phosphatase;1-phosphatidylinositol 3-phosphate 5-kinase;Synphilin-1	FIG4;PIKFYVE;SNCAIP	KIAA0274 SAC3;KIAA0981 PIP5K3;None
6187	STIP-USP7-Mdm2 complex	Human	TFIP11-USP7-MDM2 complex	O2-OS cells	Q00987;Q93009;Q9UBB9	4193;7874;None	MI:0019-coimmunoprecipitation	GO:0050821	protein stabilization	14.01	protein folding and stabilization	26460617	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase Mdm2;Ubiquitin carboxyl-terminal hydrolase 7;Tuftelin-interacting protein 11	MDM2;USP7;TFIP11	None;HAUSP;STIP
6188	STIP-USP7-p53 complex	Human	TFIP11-USP7-TP53 complex	U2-OS cells	P04637;Q93009;Q9UBB9	7157;7874;None	MI:0019-coimmunoprecipitation	GO:0050821;GO:0005654	protein stabilization;nucleoplasm	14.01	protein folding and stabilization	26460617	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cellular tumor antigen p53;Ubiquitin carboxyl-terminal hydrolase 7;Tuftelin-interacting protein 11	TP53;USP7;TFIP11	P53;HAUSP;STIP
6189	ArgRS-GlnRS-AIMP1 complex	Human	None	None	P47897;P54136;Q12904	5859;5917;9255	MI:0114-x-ray crystallography	GO:0006418;GO:0017101	tRNA aminoacylation for protein translation;aminoacyl-tRNA synthetase multienzyme complex	None	None	25288775	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Glutamine--tRNA ligase;Arginine--tRNA ligase, cytoplasmic;Aminoacyl tRNA synthase complex-interacting multifunctional protein 1	QARS1;RARS1;AIMP1	QARS;RARS;EMAP2 SCYE1
6190	p38gamma-Hsp90-K-Ras complex	Human	None	HEK-293T	P01116;P08238;P53778	3845;3326;6300	MI:0019-coimmunoprecipitation	GO:0001558	regulation of cell growth	None	None	24962213	None	K-Ras-dependent colon cancer	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	GTPase KRas;Heat shock protein HSP 90-beta;Mitogen-activated protein kinase 12	KRAS;HSP90AB1;MAPK12	KRAS2 RASK2;HSP90B HSPC2 HSPCB;ERK6 SAPK3
6191	IGF2-IGFBP2 complex	Human	None	None	P01344;P18065	3481;3485	MI:0004-affinity chromatography technology	GO:0045667;GO:0008201	regulation of osteoblast differentiation;heparin binding	None	None	24604839	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Insulin-like growth factor II;Insulin-like growth factor-binding protein 2	IGF2;IGFBP2	None;BP2 IBP2
6192	CHDH-SQSTM1-MAP1LC3 complex	Human	None	HeLa cells	Q13501;Q8NE62;Q9H492	8878;55349;84557	MI:0019-coimmunoprecipitation	GO:1904925	positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization	None	None	25483962	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Sequestosome-1;Choline dehydrogenase, mitochondrial;Microtubule-associated proteins 1A/1B light chain 3A	SQSTM1;CHDH;MAP1LC3A	ORCA OSIL;None;None
6193	ADAM12-alphaVbeta3-integrin-MMP-14 complex	Human	None	HEK-293 cells	O43184;P05106;P06756;P50281	8038;3690;3685;4323	MI:0019-coimmunoprecipitation	GO:0042981	regulation of apoptotic process	None	None	24006261	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Disintegrin and metalloproteinase domain-containing protein 12;Integrin beta-3;Integrin alpha-V;Matrix metalloproteinase-14	ADAM12;ITGB3;ITGAV;MMP14	MLTN;GP3A;MSK8 VNRA VTNR;None
6194	B-WICH complex	Human	None	HeLa cells	O00159;O60264;O75533;P35659;Q03468;Q9BQG0;Q9NR30;Q9UIG0	4641;8467;23451;7913;2074;10514;9188;9031	MI:0019-coimmunoprecipitation;MI:0226-ion exchange chromatography	GO:0003682;GO:0005634;GO:0006383	chromatin binding;nucleus;transcription by RNA polymerase III	70.10	nucleus	25883140	The 45 S rRNA, the 5 S rRNA, and the 7SL RNA are parts of the B-WICH complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Unconventional myosin-Ic;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5;Splicing factor 3B subunit 1;Protein DEK;DNA excision repair protein ERCC-6;Myb-binding protein 1A;Nucleolar RNA helicase 2;Tyrosine-protein kinase BAZ1B	MYO1C;SMARCA5;SF3B1;DEK;ERCC6;MYBBP1A;DDX21;BAZ1B	None;SNF2H, WCRF135;SAP155;None;CSB;P160;None;WBSC10 WBSCR10 WBSCR9 WSTF
6195	Stargazin-AP-2-AP-3a complex	Human	CACNG2-AP2A1-AP3D1 complex	None	O14617;O95782;Q9Y698	8943;160;10369	MI:0019-coimmunoprecipitation	GO:2000311	regulation of AMPA receptor activity	None	None	24217640	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	AP-3 complex subunit delta-1;AP-2 complex subunit alpha-1;Voltage-dependent calcium channel gamma-2 subunit	AP3D1;AP2A1;CACNG2	None;ADTAA CLAPA1;None
6196	Stargazin-Glu1-mu2 complex	Human	None	None	P42261;Q96CW1;Q9Y698	2890;1173;10369	MI:0096-pull down	GO:2000311	regulation of AMPA receptor activity	None	None	24217640	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Glutamate receptor 1;AP-2 complex subunit mu;Voltage-dependent calcium channel gamma-2 subunit	GRIA1;AP2M1;CACNG2	GLUH1 GLUR1;CLAPM1 KIAA0109;None
6197	Stargazin-Glu1-mu3 complex	Human	None	None	P42261;P53677;Q9Y698	2890;10947;10369	MI:0019-coimmunoprecipitation	GO:2000311	regulation of AMPA receptor activity	None	None	24217640	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Glutamate receptor 1;AP-3 complex subunit mu-2;Voltage-dependent calcium channel gamma-2 subunit	GRIA1;AP3M2;CACNG2	GLUH1 GLUR1;None;None
6198	Stargazin-Glu2A-mu2 complex	Human	CACNG2-GRIA2-AP2M1 complex	None	P42262;Q96CW1;Q9Y698	2891;1173;10369	MI:0019-coimmunoprecipitation	GO:2000311	regulation of AMPA receptor activity	None	None	24217640	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Glutamate receptor 2;AP-2 complex subunit mu;Voltage-dependent calcium channel gamma-2 subunit	GRIA2;AP2M1;CACNG2	GLUR2;CLAPM1 KIAA0109;None
6199	Stargazin-Glu2A-mu3 complex	Human	None	None	P42262;P53677;Q9Y698	2891;10947;10369	MI:0019-coimmunoprecipitation	GO:2000311	regulation of AMPA receptor activity	None	None	24217640	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Glutamate receptor 2;AP-3 complex subunit mu-2;Voltage-dependent calcium channel gamma-2 subunit	GRIA2;AP3M2;CACNG2	GLUR2;None;None
6203	TFAP2C-Myc-KDM5B complex	Human	None	MCF-7 cells	P01106;Q92754;Q9UGL1	4609;7022;10765	MI:0019-coimmunoprecipitation	GO:0010564	regulation of cell cycle process	None	None	22371483	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Myc proto-oncogene protein;Transcription factor AP-2 gamma;Lysine-specific demethylase 5B	MYC;TFAP2C;KDM5B	BHLHE39;None;JARID1B PLU1 RBBP2H1
6206	ICAT-AR-beta-catenin complex	Human	None	Prostate cancer cells	P10275;P35222;Q9NSA3	367;1499;56998	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0030111;GO:0051090	regulation of Wnt signaling pathway;regulation of DNA-binding transcription factor activity	18.02.09	regulator of transcription factor	21885566	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Androgen receptor;Catenin beta-1;Beta-catenin-interacting protein 1	AR;CTNNB1;CTNNBIP1	DHTR, NR3C4;CTNNB;ICAT
6208	PNP homotrimer complex	Human	None	None	P00491	4860	MI:0114-x-ray crystallography	GO:0042278;GO:0004731	purine nucleoside metabolic process;purine-nucleoside phosphorylase activity	None	None	2104852	None	None	None	Homo sapiens (Human)	Purine nucleoside phosphorylase	PNP	NP
6209	MT1-G(i)-RGS20 complex	Human	None	None	O76081;P48039;P63096	8601;4543;2770	MI:0012-bioluminescence resonance energy transfer	GO:0007187	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	None	None	20859254	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Regulator of G-protein signaling 20;Melatonin receptor type 1A;Guanine nucleotide-binding protein G(i) subunit alpha-1	RGS20;MTNR1A;GNAI1	RGSZ1 ZGAP1;None;None
6210	MT1-MT2 complex	Human	MTNR1A-MTNR1B complex	HEK-234T cells	P48039;P49286	4543;4544	MI:0019-coimmunoprecipitation	GO:0007187	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	None	None	20859254	This heterodimers contain two functional ligand binding sites that maintain their respective selectivity for MT(1) and MT(2) ligands. Occupation of either binding site is sufficient to induce a conformational change within the heterodimer. Taken together, these results show that the probability of GPCR heterodimer formation may be equal to or even higher than that of the corresponding homodimers and that specific properties of heterodimers can be revealed using a BRET-based ligand/receptor interaction assay. (PMID:15266022)	None	None	Homo sapiens (Human);Homo sapiens (Human)	Melatonin receptor type 1A;Melatonin receptor type 1B	MTNR1A;MTNR1B	None;None
6211	RSG20-MT1-MT2 complex	Human	None	None	O76081;P48039;P49286	8601;4543;4544	MI:0012-bioluminescence resonance energy transfer	GO:1901979	regulation of inward rectifier potassium channel activity	None	None	20859254	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Regulator of G-protein signaling 20;Melatonin receptor type 1A;Melatonin receptor type 1B	RGS20;MTNR1A;MTNR1B	RGSZ1 ZGAP1;None;None
6212	GM130-GRASP65 complex	Human	None	HeLa cells	Q08379;Q9BQQ3	2801;64689	MI:0114-x-ray crystallography	None	None	None	None	26363069	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Golgin subfamily A member 2;Golgi reassembly-stacking protein 1	GOLGA2;GORASP1	None;GOLPH5 GRASP65
6213	DOCK8-WIP-WASp complex	Human	DOCK8-WIPF1-WAS complex	peripheral blood T cells;  DND41 T cell line	O43516;P42768;Q8NF50	7456;7454;81704	MI:0019-coimmunoprecipitation;MI:0428-imaging technique	GO:0015629;GO:0042608;GO:0000910;GO:0001771;GO:0072678	actin cytoskeleton;T cell receptor binding;cytokinesis;immunological synapse formation;T cell migration	70.04.03;10.03.03	actin cytoskeleton;cytokinesis (cell division) /septum formation and hydrolysis	27599296	DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton. The WASp-interacting protein (WIP) bridges DOCK8 to WASp and actin in T cells. The guanine nucleotide exchange factor activity of DOCK8 is essential for the integrity of the subcortical actin cytoskeleton as well as for TCR-driven WASp activation, F-actin assembly, immune synapse formation, actin foci formation, mechanotransduction, T cell transendothelial migration, and homing to lymph nodes, all of which also depend on WASp. The results indicate that DOCK8 and WASp are in the same signaling pathway that links TCRs to the actin cytoskeleton in TCR-driven actin assembly. DOCK8 binds to and colocalizes constitutively with WIP and WASp in T cells. WIP bridges DOCK8 to actin. DOCK8 GEF activity mediates TCR-driven WASp activation. DOCK8 is essential for TCR-driven actin foci formation and mechanotransduction.	Wiskott-Aldrich syndrome (WAS) is associated with mutations in the WAS protein (WASp), which plays a critical role in the initiation of T cell receptor-driven (TCR-driven) actin polymerization. The clinical phenotype of WAS includes susceptibility to infection, allergy, autoimmunity, and malignancy and overlaps with the symptoms of dedicator of cytokinesis 8 (DOCK8) deficiency, suggesting that the 2 syndromes share common pathogenic mechanisms.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	WAS/WASL-interacting protein family member 1;Actin nucleation-promoting factor WAS;Dedicator of cytokinesis protein 8	WIPF1;WAS;DOCK8	WASPIP WIP;IMD2;None
6215	GATOR1 complex	Human	None	HEK-293T cells	O75140;Q12980;Q8WTW4	9681;8131;10641	MI:0019-coimmunoprecipitation	GO:1903832;GO:1904262;GO:0005096	regulation of cellular response to amino acid starvation;negative regulation of TORC1 signaling;GTPase activator activity	18.02.01.01.01	GTPase activator (GAP)	23723238	The loss of GATOR1 proteins prevented the inactivation of mTORC1 and dTORC1 normally caused by amino acid deprivation.	GATOR1 components are present in low single-digit percentages of glioblastomas and ovarian cancers,	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	GATOR complex protein DEPDC5;GATOR complex protein NPRL3;GATOR complex protein NPRL2	DEPDC5;NPRL3;NPRL2	KIAA0645;C16orf35 CGTHBA MARE;TUSC4
6216	GATOR2 complex	Human	None	HEK-293T cells	P55735;Q6PJI9;Q96EE3;Q96S15;Q9NXC5	6396;79726;81929;84219;54468	MI:0019-coimmunoprecipitation	GO:1903432	regulation of TORC1 signaling	None	None	23723238	Inhibition of GATOR2 subunits suppresses mTORC1 signaling. GATOR2 is an inhibitor of an inhibitor (GATOR1) of the amino acid\u2013sensing branch of the TORC1 pathway.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein SEC13 homolog;GATOR complex protein WDR59;Nucleoporin SEH1;GATOR complex protein WDR24;GATOR complex protein MIOS	SEC13;WDR59;SEH1L;WDR24;MIOS	D3S1231E SEC13A SEC13L1 SEC13R;KIAA1923;SEC13L SEH1;C16orf21;None
6217	GATOR complex	Human	None	HEK-293T cells	O75140;P55735;Q12980;Q6PJI9;Q8WTW4;Q96EE3;Q96S15;Q9NXC5	9681;6396;8131;79726;10641;81929;84219;54468	MI:0019-coimmunoprecipitation	GO:1903432;GO:1903832	regulation of TORC1 signaling;regulation of cellular response to amino acid starvation	None	None	23723238	GATOR as a complex that is composed of the two subcomplexes GATOR1 complexand GATOR2 complex. GATOR as a complex that interacts with and negatively regulates the Rag guanosine triphosphatases (GTPases) which promote mTORC1 translocation to the lysosomal surface.	Inactivating mutations in GATOR1 components were found in glioblastomas and ovarian cancers.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	GATOR complex protein DEPDC5;Protein SEC13 homolog;GATOR complex protein NPRL3;GATOR complex protein WDR59;GATOR complex protein NPRL2;Nucleoporin SEH1;GATOR complex protein WDR24;GATOR complex protein MIOS	DEPDC5;SEC13;NPRL3;WDR59;NPRL2;SEH1L;WDR24;MIOS	KIAA0645;D3S1231E SEC13A SEC13L1 SEC13R;C16orf35 CGTHBA MARE;KIAA1923;TUSC4;SEC13L SEH1;C16orf21;None
6218	POL2R-SYMPK-SSU72 complex	Human	None	None	P24928;Q92797;Q9NP77	5430;8189;29101	MI:0114-x-ray crystallography	GO:1900363	regulation of mRNA polyadenylation	None	None	20861839	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA-directed RNA polymerase II subunit RPB1;Symplekin;RNA polymerase II subunit A C-terminal domain phosphatase SSU72	POLR2A;SYMPK;SSU72	POLR2;SPK;None
6219	DGKZ-RASGRP1-HRAS complex	Human	None	HEK293 cells	O95267;P01112;Q13574	10125;3265;8525	MI:0019-coimmunoprecipitation	GO:0007265	Ras protein signal transduction	None	None	11257115	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	RAS guanyl-releasing protein 1;GTPase HRas;Diacylglycerol kinase zeta	RASGRP1;HRAS;DGKZ	RASGRP;HRAS1;DAGK6
6220	HDAC10-PAX3-KAP1 complex	Human	HDAC10-PAX3-TRIM28 complex	HEK-293 cells	P23760;Q13263;Q969S8	5077;10155;83933	MI:0019-coimmunoprecipitation;MI:0416-fluorescence microscopy	GO:0048021;GO:0003700	regulation of melanin biosynthetic process;DNA-binding transcription factor activity	None	None	20032463	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Paired box protein Pax-3;Transcription intermediary factor 1-beta;Polyamine deacetylase HDAC10	PAX3;TRIM28;HDAC10	HUP2;KAP1 RNF96 TIF1B;None
6223	CCM2-ICAP1-KRIT1 complex	Human	None	HEK-293T cells	O00522;O14713;Q9BSQ5	889;9270;83605	MI:0019-coimmunoprecipitation	GO:0007155	cell adhesion	34.07	cell adhesion	16037064	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Krev interaction trapped protein 1;Integrin beta-1-binding protein 1;Cerebral cavernous malformations 2 protein	KRIT1;ITGB1BP1;CCM2	CCM1;ICAP1;C7orf22
6224	CCM2-KRIT1-MEKK3 complex	Human	None	HEK-293T cells	O00522;Q99759;Q9BSQ5	889;4215;83605	MI:0019-coimmunoprecipitation	GO:1900744	regulation of p38MAPK cascade	None	None	16037064	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Krev interaction trapped protein 1;Mitogen-activated protein kinase kinase kinase 3;Cerebral cavernous malformations 2 protein	KRIT1;MAP3K3;CCM2	CCM1;MAPKKK3 MEKK3;C7orf22
6226	Rab11a-FIP3-DLIC-1 complex	Human	None	A-431 cells	P62491;Q9Y6G9;Q9Y6K9	8766;51143;8517	MI:0047-far western blotting	GO:0016197	endosomal transport	None	None	20026645	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Ras-related protein Rab-11A;Cytoplasmic dynein 1 light intermediate chain 1;NF-kappa-B essential modulator	RAB11A;DYNC1LI1;IKBKG	RAB11;DNCLI1;FIP3, NEMO
6229	ATG13-RB1CC1-ULK1 complex	Human	ULK1-ATG13-RB1CC1 complex; ULK1-ATG13-FIP200 complex	HEK293A cells	O75143;O75385;Q8TDY2	9776;8408;9821	MI:0019-coimmunoprecipitation	GO:1905037;GO:0006914	autophagosome organization;autophagy	None	None	18936157	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Autophagy-related protein 13;Serine/threonine-protein kinase ULK1;RB1-inducible coiled-coil protein 1	ATG13;ULK1;RB1CC1	KIAA0652;KIAA0722;KIAA0203 RBICC
6230	ATG13-RB1CC1-ULK2 complex	Human	ULK2-ATG13-RB1CC1 complex; ULK2-ATG13-FIP200 complex	HEK293A cells	O75143;Q8IYT8;Q8TDY2	9776;9706;9821	MI:0019-coimmunoprecipitation	GO:0006914;GO:1905037	autophagy;autophagosome organization	None	None	18936157	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Autophagy-related protein 13;Serine/threonine-protein kinase ULK2;RB1-inducible coiled-coil protein 1	ATG13;ULK2;RB1CC1	KIAA0652;KIAA0623;KIAA0203 RBICC
6232	ATG101-ATG13-RB1CC1-ULK1 complex	Human	ULK1-ATG13-RB1CC1-ATG101 complex; ULK1-ATG13-FIP200-ATG101 complex; Autophagy initiation complex	HEK293T cells	O75143;O75385;Q8TDY2;Q9BSB4	9776;8408;9821;60673	MI:0019-coimmunoprecipitation	GO:0006914	autophagy	None	None	19597335	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Autophagy-related protein 13;Serine/threonine-protein kinase ULK1;RB1-inducible coiled-coil protein 1;Autophagy-related protein 101	ATG13;ULK1;RB1CC1;ATG101	KIAA0652;KIAA0722;KIAA0203 RBICC;C12orf44
6233	Ubiquitin E3 ligase (CUL3, KLHL3, WNK1)	Human	CUL3-KLHL3-WNK1 E3 ligase complex	HeLa cells	Q13618;Q9H4A3;Q9UH77	8452;65125;26249	MI:0019-coimmunoprecipitation	GO:0006511;GO:0031461	ubiquitin-dependent protein catabolic process;cullin-RING ubiquitin ligase complex	14.13.01.01	proteasomal degradation (ubiquitin/proteasomal pathway)	23387299	CUL3 assembles with BTB proteins (e.g. KLHL3) to form Cullin-RING E3 ubiquitin ligase complexes. The CUL3-KLHL3 E3 ligase complex regulates blood pressure via its ability to interact with and ubiquitylate WNK isoforms. The recombinant wild-type CUL3-KLHL3 E3 ligase complex, but not a disease-causing CUL3-KLHL3[R528H] mutant complex, ubiquitylated WNK1 in vitro. siRNA (small interfering RNA)-mediated knockdown of CUL3 increased WNK1 protein levels and kinase activity in HeLa cells. The KLHL3 interaction site in WNK1 could be mapped to a non-catalytic region (residues 479-667).	The CUL3-KLHL3 E3 ligase complex is mutated in Gordon hypertension syndrome (= Pseudohypoaldosteronismtype II = PHAII).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cullin-3;Serine/threonine-protein kinase WNK1;Kelch-like protein 3	CUL3;WNK1;KLHL3	KIAA0617;HSN2 KDP KIAA0344 PRKWNK1;KIAA1129
6235	c-Fos-c-Jun-SAF-1 complex	Human	None	HTB-94 cells	P01100;P05412;P56270	2353;3725;4150	MI:0019-coimmunoprecipitation	GO:0006355;GO:0003677	regulation of DNA-templated transcription;DNA binding	11.02.03.04;16.03.01	transcriptional control;DNA binding	19028685	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein c-Fos;Transcription factor Jun;Myc-associated zinc finger protein	FOS;JUN;MAZ	G0S7;None;ZNF801
6236	Dynein-2 complex, cytoplasmic	Human	None	RPE1 cells	P51808;P63167;P63172;Q8IVD9;Q8NCM8;Q8TCX1;Q8TF09;Q8WVS4;Q8WW35;Q96EX3;Q96FJ2;Q9NP97	6990;8655;6993;23386;79659;51626;83657;55112;255758;89891;140735;83658	MI:0019-coimmunoprecipitation	GO:0035721;GO:0005929;GO:0007224;GO:0042073	intraciliary retrograde transport;cilium;smoothened signaling pathway;intraciliary transport	30.05.02.16	hedgehog-dependent signalling pathway	25205765	None	Defects in the function of primary cilia lead to a cohort of human diseases known as the ciliopathies; among these, mutations in components of the dynein-2 complex cause Jeune syndrome, short rib polydactyly type III and asphyxiating thoracic dystrophy.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Dynein light chain Tctex-type 3;Dynein light chain 1, cytoplasmic;Dynein light chain Tctex-type 1;NudC domain-containing protein 3;Cytoplasmic dynein 2 heavy chain 1;Cytoplasmic dynein 2 light intermediate chain 1;Dynein light chain roadblock-type 2;Cytoplasmic dynein 2 intermediate chain 1;Dynein light chain Tctex-type protein 2B;Cytoplasmic dynein 2 intermediate chain 2;Dynein light chain 2, cytoplasmic;Dynein light chain roadblock-type 1	DYNLT3;DYNLL1;DYNLT1;NUDCD3;DYNC2H1;DYNC2LI1;DYNLRB2;DYNC2I1;DYNLT2B;DYNC2I2;DYNLL2;DYNLRB1	TCTE1L TCTE1XL;DLC1 DNCL1 DNCLC1 HDLC1;TCTEL1 TCTEX-1 TCTEX1;KIAA1068;DHC1B DHC2 DNCH2 DYH1B KIAA1997;D2LIC LIC3;DNCL2B DNLC2B ROBLD2;WDR60;TCTEX1D2;WDR34;DLC2;BITH DNCL2A DNLC2A ROBLD1
6237	AJUBA-GFI1-HDAC1 complex	Human	None	Jurkat T cell nuclear extracts	Q13547;Q96IF1;Q99684	3065;84962;2672	MI:0019-coimmunoprecipitation;MI:0071-molecular sieving	GO:0045892	negative regulation of DNA-templated transcription	11.02.03.04.03	transcription repression	18805794	The majority of Gfi1 repression activity is dependent upon HDAC function. However, a residual repression activity is present in inhibitor-treated samples suggesting Gfi1 and Ajuba utilize as yet unidentified non-HDAC-dependent repression mechanism(s).	It has been demonstrated that SCN (severe congenital neutropenia)-associated mutations in GFI1 generate dominant-negative-acting proteins (GFI1N382S), which selectively deprepress GFI1 target genes such as CSF1. A SNAG domain mutant protein (Gfi1P2A) also functioned in a dominant negative manner;however, a protein with both mutations (Gfi1P2A\u0002N382S) lacked dominant negative activity.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone deacetylase 1;LIM domain-containing protein ajuba;Zinc finger protein Gfi-1	HDAC1;AJUBA;GFI1	RPD3L1;JUB;ZNF163
6238	DHDDS-NUS1 complex	Human	None	HeLa cells	Q86SQ9;Q96E22	79947;116150	MI:0019-coimmunoprecipitation	GO:0043048;GO:0006486;GO:0005783;GO:0042632	dolichyl monophosphate biosynthetic process;protein glycosylation;endoplasmic reticulum;cholesterol homeostasis	14.07.02;70.07;34.01.07	modification with sugar residues (e.g. glycosylation, deglycosylation);endoplasmic reticulum;cholesterol homeostasis	21572394	Dolichol monophosphate (Dol-P) functions as an obligate glycosyl carrier lipid in protein glycosylation reactions. Nogo-B receptor (NUS1)as an essential component of the Dol-P biosynthetic machinery.	A Mutation on NgBR Causes Congenital Scoliosis, Severe Neurological Impairment, Refractory Epilepsy, Hearing Deficit, and Visual Impairment.	None	Homo sapiens (Human);Homo sapiens (Human)	Dehydrodolichyl diphosphate synthase complex subunit DHDDS;Dehydrodolichyl diphosphate synthase complex subunit NUS1	DHDDS;NUS1	HDS;C6orf68 NGBR
6242	14-3-3q-SGK1-tau complex	Human	YWHAQ-SGK1-MAPT complex	None	O00141;P10636;P27348	6446;4137;10971	MI:0096-pull down	GO:0001932	regulation of protein phosphorylation	None	None	15650334	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein kinase Sgk1;Microtubule-associated protein tau;14-3-3 protein theta	SGK1;MAPT;YWHAQ	SGK;MAPTL MTBT1 TAU;None
6243	AJUBA-GFI1-HDAC2 complex	Human	None	Jurkat T cell nuclear extracts	Q92769;Q96IF1;Q99684	3066;84962;2672	MI:0019-coimmunoprecipitation;MI:0071-molecular sieving	GO:0045892	negative regulation of DNA-templated transcription	11.02.03.04.03	transcription repression	18805794	The majority of Gfi1 repression activity is dependent upon HDAC function. However, a residual repression activity is present in inhibitor-treated samples suggesting Gfi1 and Ajuba utilize as yet unidentified non-HDAC-dependent repression mechanism(s).	It has been demonstrated that SCN (severe congenital neutropenia)-associated mutations in GFI1 generate dominant-negative-acting proteins (GFI1N382S), which selectively deprepress GFI1 target genes such as CSF1. A SNAG domain mutant protein (Gfi1P2A) also functioned in a dominant negative manner;however, a protein with both mutations (Gfi1P2A\u0002N382S) lacked dominant negative activity.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone deacetylase 2;LIM domain-containing protein ajuba;Zinc finger protein Gfi-1	HDAC2;AJUBA;GFI1	None;JUB;ZNF163
6244	AJUBA-GFI1-HDAC3 complex	Human	None	Jurkat T cell nuclear extracts	O15379;Q96IF1;Q99684	8841;84962;2672	MI:0019-coimmunoprecipitation;MI:0071-molecular sieving	GO:0045892	negative regulation of DNA-templated transcription	11.02.03.04.03	transcription repression	18805794	The majority of Gfi1 repression activity is dependent upon HDAC function. However, a residual repression activity is present in inhibitor-treated samples suggesting Gfi1 and Ajuba utilize as yet unidentified non-HDAC-dependent repression mechanism(s).	It has been demonstrated that SCN (severe congenital neutropenia)-associated mutations in GFI1 generate dominant-negative-acting proteins (GFI1N382S), which selectively deprepress GFI1 target genes such as CSF1. A SNAG domain mutant protein (Gfi1P2A) also functioned in a dominant negative manner;however, a protein with both mutations (Gfi1P2A\u0002N382S) lacked dominant negative activity.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone deacetylase 3;LIM domain-containing protein ajuba;Zinc finger protein Gfi-1	HDAC3;AJUBA;GFI1	None;JUB;ZNF163
6245	Telomerase holoenzyme	Human	None	HeLa S3 cells	O14746;O60832;Q86US8;Q9BUR4;Q9NPE3;Q9NX24;Q9NY12	7015;1736;23293;55135;55505;55651;54433	MI:0019-coimmunoprecipitation	GO:0003720;GO:0005697	telomerase activity;telomerase holoenzyme complex	None	None	19179534	.	Telomerase is associated with various diseases such as cancer, dyskeratosis congenita, bone marrow failure and idiopathic pulmonary fibrosis	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Telomerase reverse transcriptase;H/ACA ribonucleoprotein complex subunit DKC1;Telomerase-binding protein EST1A;Telomerase Cajal body protein 1;H/ACA ribonucleoprotein complex subunit 3;H/ACA ribonucleoprotein complex subunit 2;H/ACA ribonucleoprotein complex subunit 1	TERT;DKC1;SMG6;WRAP53;NOP10;NHP2;GAR1	EST2 TCS1 TRT;NOLA4;C17orf31 EST1A KIAA0732;TCAB1 WDR79;NOLA3;NOLA2;NOLA1
6246	BBS4 centriolar satellite complex	Human	BBS4-PCM1-CEP131 complex; BBS4-PCM1-AZI1 complex	HEK293T cells	Q15154;Q96RK4;Q9UPN4	5108;585;22994	MI:0029-cosedimentation through density gradient	GO:0005929;GO:0042073;GO:0034451;GO:0060271	cilium;intraciliary transport;centriolar satellite;cilium assembly	None	None	24550735	None	Bardet-Biedl syndrome (BBS) is a well-known ciliopathy with mutations reported in 18 different genes. Most of the protein products of the BBS genes localize at or near the primary cilium and the centrosome. Near the centrosome, BBS proteins interact with centriolar satellite proteins, and the BBSome (a complex of seven BBS proteins) is believed to play a role in transporting ciliary membrane proteins.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Pericentriolar material 1 protein;Bardet-Biedl syndrome 4 protein;Centrosomal protein of 131 kDa	PCM1;BBS4;CEP131	None;None;AZI1 KIAA1118
6247	BBS-chaperonin complex	Human	BBS/CCT complex	HEK293T cells	P17987;P48643;P49368;P50990;P50991;P78371;Q6ZW61;Q8IWZ6;Q8TAM1;Q9NPJ1	6950;22948;7203;10694;10575;10576;166379;55212;79738;8195	MI:0019-coimmunoprecipitation	GO:0005929;GO:0051131;GO:0042073	cilium;chaperone-mediated protein complex assembly;intraciliary transport	None	None	20080638	The assembly of the BBSome requires the activity of the BBS-chaperonin complex (PMID: 30287585).	Bardet-Biedl syndrome (BBS) is a human genetic disorder resulting in obesity, retinal degeneration, polydactyly, and nephropathy. Studies indicate that trafficking defects to the ciliary membrane are involved in this syndrome.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	T-complex protein 1 subunit alpha;T-complex protein 1 subunit epsilon;T-complex protein 1 subunit gamma;T-complex protein 1 subunit theta;T-complex protein 1 subunit delta;T-complex protein 1 subunit beta;Bardet-Biedl syndrome 12 protein;Bardet-Biedl syndrome 7 protein;Bardet-Biedl syndrome 10 protein;Molecular chaperone MKKS	TCP1;CCT5;CCT3;CCT8;CCT4;CCT2;BBS12;BBS7;BBS10;MKKS	CCT1 CCTA;CCTE KIAA0098;CCTG TRIC5;C21orf112 CCTQ KIAA0002;CCTD SRB;99D8.1 CCTB;C4orf24;BBS2L1;C12orf58;BBS6
6248	CSF3R-FBXW7-GSK3B complex	Human	None	HEK 293T cells	P49841;Q969H0;Q99062	2932;55294;1441	MI:0019-coimmunoprecipitation	GO:0031146;GO:0030851;GO:0038158	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;granulocyte differentiation;granulocyte colony-stimulating factor signaling pathway	43.03.07.02.02	granulocyte	23820376	Fbw7 in cooperation with GSK3B negatively modulates G-CSFR protein steady state levels by promoting its degradation and thus regulates granulocytic differentiation.	Fbw7 also interacts with and degrades G-CSFR-T718 (a truncated mutant of G-CSFR found in severe congenital neutropenia/acute myeloid leukemia (SCN/AML patients)) though at a quite slower rate compared to G-CSFR.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Glycogen synthase kinase-3 beta;F-box/WD repeat-containing protein 7;Granulocyte colony-stimulating factor receptor	GSK3B;FBXW7;CSF3R	None;FBW7 FBX30 SEL10;GCSFR
6249	MIB complex, mitochondrial	Human	Mitochondrial intermembrane space bridging complex; MICOS-SAM complex, mitochondrial	human osteosarcoma 143B cells; human skin fibroblasts	O75431;Q13505;Q16891;Q5HYI7;Q5TGZ0;Q5XKP0;Q6UXV4;Q9BRQ6;Q9BUR5;Q9NVH1;Q9NX63;Q9Y512	10651;4580;10989;None;440574;125988;139322;84303;79135;55735;54927;25813	MI:0276-blue native page	GO:0044284;GO:0042407;GO:0061617;GO:0005741;GO:0005743;GO:0001401;GO:0006626;GO:0006839;GO:0005739	mitochondrial crista junction;cristae formation;MICOS complex;mitochondrial outer membrane;mitochondrial inner membrane;SAM complex;protein targeting to mitochondrion;mitochondrial transport;mitochondrion	70.16.01;70.16.05;20.09.04;70.16	mitochondrial outer membrane;mitochondrial inner membrane;mitochondrial transport;mitochondrion	26477565	Mitochondrial inner membrane folds into cristae, which significantly increase its surface and are important for mitochondrial function. The stability of cristae depends on the mitochondrial contact site (MICOS) complex. In human mitochondria, the inner membrane MICOS complex interacts with the outer membrane sorting and assembly machinery (SAM) complex, to form the mitochondrial intermembrane space bridging complex (MIB). The most important subunits of the MIB complex in human mitochondria are Mic60/Mitofilin, Mic19/CHCHD3 and an outer membrane component Sam50 (PMID: 25781180). SAM50 is a critical stabilizing protein of the MIB complex responsible for protein transport, assembly of respiratory chain complexes and regulation of cristae integrity (PMID:34385433). MTX3 (metaxin 3) was also found to be a component of the MIB complex (PMID:26477565).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Metaxin-2;Metaxin-1;MICOS complex subunit MIC60;Metaxin-3;MICOS complex subunit MIC10;MICOS complex subunit MIC13;MICOS complex subunit MIC27;MICOS complex subunit MIC25;MICOS complex subunit MIC26;DnaJ homolog subfamily C member 11;MICOS complex subunit MIC19;Sorting and assembly machinery component 50 homolog	MTX2;MTX1;IMMT;MTX3;MICOS10;MICOS13;APOOL;CHCHD6;APOO;DNAJC11;CHCHD3;SAMM50	None;MTX MTXN;HMP MIC60 MINOS2;None;C1orf151 MIC10 MINOS1;C19orf70 MIC13 QIL1;CXorf33 FAM121A MIC27;CHCM1 MIC25;FAM121B MIC23 MIC26;None;MIC19, MINOS3;SAM50
6250	LPA(2)-NHERF2-PLC-beta3 complex	Human	None	None	Q01970;Q15599;Q9HBW0	5331;9351;9170	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0019216	regulation of lipid metabolic process	01.06.10	regulation of lipid, fatty acid and isoprenoid metabolism	15143197	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3;Na(+)/H(+) exchange regulatory cofactor NHE-RF2;Lysophosphatidic acid receptor 2	PLCB3;SLC9A3R2;LPAR2	None;NHERF2;EDG4, LPA2
6251	Shc-ERalpha-IGF-1R complex	Human	SHC1-ESR1-	MCF-7 cells	P03372;P08069;P29353	2099;3480;6464	MI:0019-coimmunoprecipitation	GO:0043405	regulation of MAP kinase activity	None	None	14764897	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Estrogen receptor;Insulin-like growth factor 1 receptor;SHC-transforming protein 1	ESR1;IGF1R;SHC1	ESR NR3A1;None;SHC SHCA
6253	MYO5B-RAB11A-RAB11FIP2 complex	Human	myosin-Vb-Rab11-FIP2-Rab11a complex	HeLa cells	P62491;Q7L804;Q9ULV0	8766;22841;4645	MI:0096-pull down	GO:0016192	vesicle-mediated transport	20.09.07	vesicular transport (Golgi network, etc.)	12393859	Rab11 family interacting protein 2 associates with Myosin Vb and regulates plasma membrane recycling.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Ras-related protein Rab-11A;Rab11 family-interacting protein 2;Unconventional myosin-Vb	RAB11A;RAB11FIP2;MYO5B	RAB11;KIAA0941;KIAA1119
6254	GPC-4.1R-p55 complex	Human	None	erythrocyte cells	P04921;P11171;Q00013	2995;2035;4354	MI:0107-surface plasmon resonance	None	None	None	None	10831591	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Glycophorin-C;Protein 4.1;55 kDa erythrocyte membrane protein	GYPC;EPB41;MPP1	GLPC GPC;E41P;DXS552E EMP55
6255	MICOS complex, mitochondrial	Human	MIB subcomplex, mitochondrial; Mitochondrial contact site and cristae junction organizing system	human osteosarcoma 143B cells; human skin fibroblasts	Q16891;Q5TGZ0;Q5XKP0;Q6UXV4;Q9BRQ6;Q9BUR5;Q9NX63	10989;440574;125988;139322;84303;79135;54927	MI:0276-blue native page	GO:0061617;GO:0042407	MICOS complex;cristae formation	None	None	26477565	Mitochondrial inner membrane folds into cristae, which significantly increase its surface and are important for mitochondrial function. The stability of cristae depends on the mitochondrial contact site (MICOS) complex. In human mitochondria, the inner membrane MICOS complex interacts with the outer membrane sorting and assembly machinery (SAM) complex, to form the mitochondrial intermembrane space bridging complex (MIB) (PMID: 25781180).	Several mitochondrial disorders in humans are often accompanied by alterations of mitochondrial ultrastructure including MERRF syndrome (Myoclonic epilepsy with ragged red fibers), BTHS (Barth syndrome), fatal neonatal lactic acidosis, mtDNA defects and hypertrophic cardiomyopathy and loss of CJs with the formation of concentric stacks of cristae membrane are some of the hallmarks observed in mitochondria from such patients.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	MICOS complex subunit MIC60;MICOS complex subunit MIC10;MICOS complex subunit MIC13;MICOS complex subunit MIC27;MICOS complex subunit MIC25;MICOS complex subunit MIC26;MICOS complex subunit MIC19	IMMT;MICOS10;MICOS13;APOOL;CHCHD6;APOO;CHCHD3	HMP MIC60 MINOS2;C1orf151 MIC10 MINOS1;C19orf70 MIC13 QIL1;CXorf33 FAM121A MIC27;CHCM1 MIC25;FAM121B MIC23 MIC26;MIC19, MINOS3
6257	ANKS6-NEK8-INVS-NPHP3 complex	Human	NPHP16-NPHP9-NPHP2-NPHP3 complex	HEK-293T cells	Q68DC2;Q7Z494;Q86SG6;Q9Y283	203286;27031;284086;27130	MI:0019-coimmunoprecipitation	GO:0005929;GO:0001822	cilium;kidney development	47.03.07.01	kidney	23793029	None	Nephronophthisis is the most frequent genetic cause of renal failure in children, presenting  with cystic kidney disease combined with extrarenal manifestations, such as retinitis pigmentosa (Senior-Loken syndrome), liver fibrosis, cerebellar vermis hypoplasia (Joubert syndrome), situs inversus or cardiac malformations. Because most NPHP gene products  localize to the cilium or its associated structures, nephronophthisis and related syndromes, such as Joubert syndrome and Meckel-Gruber syndrome (MKS), have been termed ciliopathies.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Ankyrin repeat and SAM domain-containing protein 6;Nephrocystin-3;Serine/threonine-protein kinase Nek8;Inversin	ANKS6;NPHP3;NEK8;INVS	ANKRD14 PKDR1 SAMD6;KIAA2000;JCK NEK12A;INV NPHP2
6259	USH2 complex	Human	WHRN-USH2A-PDZD7-GPR98 complex; Usher Syndrome Type 2 complex	HEK293 cells	O75445;Q8WXG9;Q9H5P4;Q9P202	7399;84059;79955;25861	MI:0096-pull down	None	None	None	None	25406310	None	None	It was shown  that multiple domains of the four USH proteins interact among one another. Importantly, both WHRN and PDZD7 are required for the complex formation with USH2A and GPR98. In this USH2 quaternary complex, WHRN prefers to bind to USH2A, whereas PDZD7 prefers to bind to GPR98. Interaction between WHRN and PDZD7 is the bridge between USH2A and GPR98. Additionally, the USH2 quaternary complex has a variable stoichiometry. (PMID: 25406310)	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Usherin;Adhesion G-protein coupled receptor V1;PDZ domain-containing protein 7;Whirlin	USH2A;ADGRV1;PDZD7;WHRN	None;GPR98 KIAA0686 KIAA1943 MASS1 VLGR1;PDZK7;DFNB31 KIAA1526
6260	MPP7-DLG1-LIN7A complex	Human	None	HEK 293 cells	O14910;Q12959;Q5T2T1	8825;1739;143098	MI:0007-anti tag coimmunoprecipitation	GO:0097025;GO:0030054	MPP7-DLG1-LIN7 complex;cell junction	70.06	cell junction	17237226	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein lin-7 homolog A;Disks large homolog 1;MAGUK p55 subfamily member 7	LIN7A;DLG1;MPP7	MALS1 VELI1;None;None
6261	Histone-2-Histone-4-ASF1A-MCM2 complex	Human	HIST1H3A-HIST1H4A-ASF1A-MCM2 complex	None	P49736;P62805;P68431;Q9Y294	4171;None;None;25842	MI:0114-x-ray crystallography	GO:0006325	chromatin organization	None	None	26186914	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA replication licensing factor MCM2;Histone H4;Histone H3.1;Histone chaperone ASF1A	MCM2;H4C1;H3C1;ASF1A	BM28 CCNL1 CDCL1 KIAA0030;H4/A H4FA HIST1H4A;H3FA,HIST1H3A;None
6263	MPP7-DLG1-LIN7C complex	Human	None	HEK 293 cells	Q12959;Q5T2T1;Q9NUP9	1739;143098;55327	MI:0007-anti tag coimmunoprecipitation	GO:0097025	MPP7-DLG1-LIN7 complex	None	None	17237226	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Disks large homolog 1;MAGUK p55 subfamily member 7;Protein lin-7 homolog C	DLG1;MPP7;LIN7C	None;None;MALS3 VELI3
6264	DLG5-SORBS3-CTNNB1 complex	Human	None	COS-7 cells	O60504;P35222;Q8TDM6	10174;1499;9231	MI:0019-coimmunoprecipitation	GO:0005911	cell-cell junction	70.06.04	intercellular junction (gap junction/adherens junction)	12657639	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Vinexin;Catenin beta-1;Disks large homolog 5	SORBS3;CTNNB1;DLG5	SCAM1;CTNNB;KIAA0583 PDLG
6266	Ubiquitin E3 ligase (CUL3, KLHL3, WNK4)	Human	CUL3-KLHL3-WNK4 E3 ligase complex	HEK293 cells	Q13618;Q96J92;Q9UH77	8452;65266;26249	MI:0019-coimmunoprecipitation	GO:0016874;GO:0016567;GO:0050801;GO:0000151;GO:0006511;GO:0031461	ligase activity;protein ubiquitination;ion homeostasis;ubiquitin ligase complex;ubiquitin-dependent protein catabolic process;cullin-RING ubiquitin ligase complex	14.07.05;34.01;14.13.01.01	modification by ubiquitination, deubiquitination;homeostasis;proteasomal degradation (ubiquitin/proteasomal pathway)	23387299	CUL3 assembles with BTB proteins (e.g. KLHL3) to form Cullin-RING E3 ubiquitin ligase complexes. The CUL3-KLHL3 E3 ligase complex regulates blood pressure via its ability to interact with and ubiquitylate WNK isoforms. Immunoprecipitation studies confirmed that the wild-type WNK4 robustly bound to KLHL3, but interaction with either disease-causing WNK4 mutant tested was strikingly impaired.	The CUL3-KLHL3 E3 ligase complex is mutated in Gordon hypertension syndrome (= Pseudohypoaldosteronismtype II = PHAII).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cullin-3;Serine/threonine-protein kinase WNK4;Kelch-like protein 3	CUL3;WNK4;KLHL3	KIAA0617;PRKWNK4;KIAA1129
6267	Ubiquitin E3 ligase (CUL3, KLHL3)	Human	CUL3\u2013KLHL3 complex	HEK-293 cells	Q13618;Q9UH77	8452;26249	MI:0019-coimmunoprecipitation	GO:0016874;GO:0016567;GO:0050801;GO:0000151;GO:0006511;GO:0031461	ligase activity;protein ubiquitination;ion homeostasis;ubiquitin ligase complex;ubiquitin-dependent protein catabolic process;cullin-RING ubiquitin ligase complex	14.07.05;34.01;14.13.01.01	modification by ubiquitination, deubiquitination;homeostasis;proteasomal degradation (ubiquitin/proteasomal pathway)	23387299	CUL3 assembles with BTB proteins (e.g. KLHL3) to form Cullin-RING E3 ubiquitin ligase complexes. The CUL3-KLHL3 E3 ligase complex regulates blood pressure via its ability to interact with and ubiquitylate WNK isoforms.	The CUL3-KLHL3 E3 ligase complex is mutated in Gordon hypertension syndrome (= Pseudohypoaldosteronismtype II = PHAII).	None	Homo sapiens (Human);Homo sapiens (Human)	Cullin-3;Kelch-like protein 3	CUL3;KLHL3	KIAA0617;KIAA1129
6268	Cullin-RING E3 ubiquitin ligase complex (ASB9, CUL5, TCEB1, TCEB2)	Human	ASB9-ELOBC-CUL5 quaternary complex; CRL	human proteins coexpressed in E.coli	Q15369;Q15370;Q93034;Q96DX5	6921;6923;8065;140462	MI:0013-biophysical;MI:0069-mass spectrometry studies of complexes	GO:0031461;GO:0031466;GO:0000209	cullin-RING ubiquitin ligase complex;Cul5-RING ubiquitin ligase complex;protein polyubiquitination	None	None	23837592	Cullin RING E3 ubiquitin ligase (CRL) complexes catalyze the specific polyubiquitination of cellular proteins to target them for degradation by the proteasome. ASB9 is unstable alone but forms a stable ternary complex with EloBC that binds with high affinity to the Cullin 5 N-terminal domain (Cul5NTD) but not to Cul2NTD. The application of several biophysical techniques are described including differential scanning fluorimetry, isothermal titration calorimetry (ITC), nanoelectrospray ionization, and ion-mobility mass spectrometry (IM-MS) to provide structural and thermodynamic information for the quaternary ASB CRL complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Elongin-C;Elongin-B;Cullin-5;Ankyrin repeat and SOCS box protein 9	ELOC;ELOB;CUL5;ASB9	TCEB1;TCEB2;VACM1;None
6269	DLL1-CTNNB1-CDH2 complex	Human	None	HEK 293E cells	O00548;P19022;P35222	28514;1000;1499	MI:0019-coimmunoprecipitation	GO:0005912;GO:0071896	adherens junction;protein localization to adherens junction	None	None	15908431	Experimental results suggest that Dll1 is presented on the surface of adherens junctions formed at the apical termini of processes through interaction with MAGI1 to activate Notch on neighboring cells in the developing central nervous system.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Delta-like protein 1;Cadherin-2;Catenin beta-1	DLL1;CDH2;CTNNB1	None;CDHN NCAD;CTNNB
6274	HEXA-HEXB complex	Human	beta-hexosaminidase A complex	placenta cells	P06865;P07686	3073;3074	MI:0114-x-ray crystallography	GO:0004563;GO:0005975;GO:0006687;GO:0030203;GO:0004553	beta-N-acetylhexosaminidase activity;carbohydrate metabolic process;glycosphingolipid metabolic process;glycosaminoglycan metabolic process;hydrolase activity, hydrolyzing O-glycosyl compounds	01.05	C-compound and carbohydrate metabolism	16698036	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Beta-hexosaminidase subunit alpha;Beta-hexosaminidase subunit beta	HEXA;HEXB	None;None
6275	HEXB homodimer complex	Human	beta-Hexosaminidase B complex	placenta cells	P07686	3074	MI:0114-x-ray crystallography	GO:0004563;GO:0005975;GO:0006687;GO:0030203;GO:0004553	beta-N-acetylhexosaminidase activity;carbohydrate metabolic process;glycosphingolipid metabolic process;glycosaminoglycan metabolic process;hydrolase activity, hydrolyzing O-glycosyl compounds	01.05	C-compound and carbohydrate metabolism	12662933	None	None	None	Homo sapiens (Human)	Beta-hexosaminidase subunit beta	HEXB	None
6277	Rev1-Rev3-Rev7-Polkappa complex	Human	REV1-REV3L-MAD2L2-POLK complex	None	O60673;Q9UBT6;Q9UBZ9;Q9UI95	5980;51426;51455;10459	MI:0055-fluorescent resonance energy transfer	GO:1904331	regulation of error-prone translesion synthesis	None	None	23143872	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA polymerase zeta catalytic subunit;DNA polymerase kappa;DNA repair protein REV1;Mitotic spindle assembly checkpoint protein MAD2B	REV3L;POLK;REV1;MAD2L2	POLZ REV3;DINB1;REV1L;MAD2B REV7
6280	NEDD8-NUB1-NPLOC4-UFD1L complex	Human	None	HEK-293T cells	Q15843;Q8TAT6;Q92890;Q9Y5A7	4738;55666;7353;51667	MI:0096-pull down	GO:2000434	regulation of protein neddylation	None	None	24019527	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	NEDD8;Nuclear protein localization protein 4 homolog;Ubiquitin recognition factor in ER-associated degradation protein 1;NEDD8 ultimate buster 1	NEDD8;NPLOC4;UFD1;NUB1	None;KIAA1499 NPL4;UFD1L;NYREN18
6282	G alpha-13-Hax-1-cortactin-Rac complex	Human	None	COS-7 cells	O00165;P31749;Q14247;Q14344	10456;207;2017;10672	MI:0019-coimmunoprecipitation	GO:0016477	cell migration	34.05.01	cell migration	15339924	By tethering G alpha-\u000113 to cortactin in a complex containing Rac, Hax-1 provides a signaling nexus that facilitates the dynamic and uninterrupted transmission of signals from G alpha-\u000113 to cortactin through Rac to promote cell protrusion and migration.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	HCLS1-associated protein X-1;RAC-alpha serine/threonine-protein kinase;Src substrate cortactin;Guanine nucleotide-binding protein subunit alpha-13	HAX1;AKT1;CTTN;GNA13	HS1BP1;PKB RAC;EMS1;None
6283	SIVA1-XIAP-TAK1 complex	Human	None	Jurkat T cells	O15304;O43318;P98170	10572;6885;331	MI:0019-coimmunoprecipitation	GO:0007249	I-kappaB kinase/NF-kappaB signaling	30.01.05.01.04	NIK-I-kappaB/NF-kappaB cascade	19584092	XIAP, SIVA1 and TAK1 form a ternary complex in Jurkat T cells. Complex formation increases after PMA/Iono stimulation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Apoptosis regulatory protein Siva;Mitogen-activated protein kinase kinase kinase 7;E3 ubiquitin-protein ligase XIAP	SIVA1;MAP3K7;XIAP	SIVA;TAK1;API3 BIRC4 IAP3
6287	SLC2A1-DMTN-ADD2 complex	Human	None	human erythrocyte ghosts	P11166;P35612;Q08495	6513;119;2039	MI:0019-coimmunoprecipitation	GO:0003779;GO:0030507;GO:0016020	actin binding;spectrin binding;membrane	None	None	18347014	The authors proposed model predicts a major role of GLUT1 interactions with dematin and adducin in stabilizing the vertical linkage of the junctional complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Solute carrier family 2, facilitated glucose transporter member 1;Beta-adducin;Dematin	SLC2A1;ADD2;DMTN	GLUT1;ADDB;DMT EPB49
6289	prohibitin 2 complex, mitochondrial	Human	None	HeLa cells	O00165;P05141;P35232;P45880;Q99623	10456;292;5245;7417;11331	MI:0007-anti tag coimmunoprecipitation	GO:0006915;GO:0008637	apoptotic process;apoptotic mitochondrial changes	40.10.02;40.10.02.02.01	apoptosis (type I programmed cell death);apoptotic mitochondrial changes	17008324	Human PHB2 has pleiotropic functions in the mitochondria, including inhibition of apoptosis via the PHB2-\u0001Hax-1 complex and regulation of the mitochondrial morphology.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	HCLS1-associated protein X-1;ADP/ATP translocase 2;Prohibitin 1;Voltage-dependent anion-selective channel protein 2;Prohibitin-2	HAX1;SLC25A5;PHB1;VDAC2;PHB2	HS1BP1;AAC2 ANT2;PHB;None;BAP, REA
6290	Ubiquitin E3 ligase (DDB1, DYRK2, EDD, VPRBP)	Human	EDVP\u2013DYRK2 complex	HEK293T cells	O95071;Q16531;Q92630;Q9Y4B6	51366;1642;8445;9730	MI:0676-tandem affinity purification	GO:0044772;GO:0006511;GO:0006468	mitotic cell cycle phase transition;ubiquitin-dependent protein catabolic process;protein phosphorylation	14.13.01.01;14.07.03	proteasomal degradation (ubiquitin/proteasomal pathway);modification by phosphorylation, dephosphorylation, autophosphorylation	19287380	EDVP\u2013DYRK2 complex regulates katanin p60 ubiquitylation. EDVP\u2013DYRK2 complex controls mitotic transition through the modulation of katanin protein levels.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase UBR5;DNA damage-binding protein 1;Dual specificity tyrosine-phosphorylation-regulated kinase 2;DDB1- and CUL4-associated factor 1	UBR5;DDB1;DYRK2;DCAF1	EDD EDD1 HYD KIAA0896;XAP1;None;KIAA0800 RIP VPRBP
6291	Ubiquitin E3 ligase (DDIT4, DDB1, BTRC, CUL4A)	Human	None	HEK293 cells	Q13619;Q16531;Q9NX09;Q9Y297	8451;1642;54541;8945	MI:0007-anti tag coimmunoprecipitation	GO:0032006;GO:0006511;GO:0006468;GO:0001666	regulation of TOR signaling;ubiquitin-dependent protein catabolic process;protein phosphorylation;response to hypoxia	14.13.01.01;14.07.03	proteasomal degradation (ubiquitin/proteasomal pathway);modification by phosphorylation, dephosphorylation, autophosphorylation	19557001	The CUL4A\u2013DDB1\u2013ROC1\u2013b-TRCP ubiquitin ligase complex acts to regulate mTOR signalling by modulating the stability of REDD1. REDD1 is a recently described component of the stress response. REDD1 was first identified as a gene induced by hypoxia and DNA damage.	Decreased REDD1 mRNA expression hasbeen observed in primary breast tumours.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cullin-4A;DNA damage-binding protein 1;DNA damage-inducible transcript 4 protein;F-box/WD repeat-containing protein 1A	CUL4A;DDB1;DDIT4;BTRC	None;XAP1;REDD1 RTP801;BTRCP FBW1A FBXW1A
6292	HAX-1-XIAP complex	Human	None	HEK 293T cells, Bosc 23 cells	O00165;P98170	10456;331	MI:0007-anti tag coimmunoprecipitation	GO:0006915;GO:1902915	apoptotic process;negative regulation of protein polyubiquitination	40.10.02	apoptosis (type I programmed cell death)	20171186	The formation of the HAX-1\u2013XIAP complex inhibits apoptosis by enhancing the stability of XIAP against proteosomal degradation.	None	None	Homo sapiens (Human);Homo sapiens (Human)	HCLS1-associated protein X-1;E3 ubiquitin-protein ligase XIAP	HAX1;XIAP	HS1BP1;API3 BIRC4 IAP3
6293	DDN-MAGI2-SH3KBP1 complex	Human	None	COS-7 cells	O94850;Q86UL8;Q96B97	23109;9863;30011	MI:0019-coimmunoprecipitation	GO:0043197	dendritic spine	None	None	16751601	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Dendrin;Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2;SH3 domain-containing kinase-binding protein 1	DDN;MAGI2;SH3KBP1	KIAA0749;ACVRINP1 AIP1 KIAA0705;CIN85
6294	DDR1-PRKCZ-WWC1 complex	Human	None	HEK-293 cells	Q05513;Q08345;Q8IX03	5590;780;23286	MI:0019-coimmunoprecipitation	GO:0035556	intracellular signal transduction	30.01	cellular signalling	18190796	DDR1, PRKCZ and WWC1 interact in atripartite complex, but predominantly in the absence of collagen.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein kinase C zeta type;Epithelial discoidin domain-containing receptor 1;Protein KIBRA	PRKCZ;DDR1;WWC1	PKC2;CAK EDDR1 NEP NTRK4 PTK3A RTK6 TRKE;KIAA0869
6295	CR2-CD19 complex	Human	CD21-CD19 complex	Raji B lymphoblastoid cells	P15391;P20023	930;1380	MI:0019-coimmunoprecipitation	GO:0006955	immune response	36.25.16	immune response	1702139	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	B-lymphocyte antigen CD19;Complement receptor type 2	CD19;CR2	None;C3DR
6296	SPATA2-CYLD complex	Human	None	U2OS cells	Q9NQC7;Q9UM82	1540;9825	MI:0071-molecular sieving	GO:0007249;GO:1902528	I-kappaB kinase/NF-kappaB signaling;regulation of protein linear polyubiquitination	30.01.05.01.04	NIK-I-kappaB/NF-kappaB cascade	27591049	CYLD is a constitutive dimer in solution and forms a 2:2 complex with SPATA2.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Ubiquitin carboxyl-terminal hydrolase CYLD;Spermatogenesis-associated protein 2	CYLD;SPATA2	CYLD1 KIAA0849;KIAA0757, PD1
6297	GP1BA-VWF complex	Human	vWF-GPIb complex	in vitro	P04275;P07359	7450;2811	MI:0019-coimmunoprecipitation	GO:0030193	regulation of blood coagulation	None	None	7887899	von Willebrand factor (vWF) is a multimeric plasma protein that mediates the adhesion of platelets to vascular subendothelium exposed to flowing blood as a consequence of tissue damage. During this phenomenon exposed vessel-wall extracellular matrix collagens interact with circulating vWF. Subsequently, at sufficiently elevated shear forces, collagen-bound vWF interacts with the glycoprotein lb (GPIb) receptor located on circulating platelets.	None	None	Homo sapiens (Human);Homo sapiens (Human)	von Willebrand factor;Platelet glycoprotein Ib alpha chain	VWF;GP1BA	F8VWF;None
6299	ELK1-SAP1a-EWS-FLI-FLI complex	Human	None	None	P19419;P28324;Q01543;Q16198	2002;2005;2313;None	MI:0071-molecular sieving	GO:0006355	regulation of DNA-templated transcription	11.02.03.04	transcriptional control	9010223	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	ETS domain-containing protein Elk-1;ETS domain-containing protein Elk-4;Friend leukemia integration 1 transcription factor;EWS-Fli1 protein	ELK1;ELK4;FLI1;EWS-Fli1	;SAP1;None;None
6300	CDKN1A-TP53-CDK1-PCNA complex	Human	None	None	P04637;P06493;P38936	7157;983;1026	MI:0045-experimental interaction detection	None	None	None	None	7624128	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cellular tumor antigen p53;Cyclin-dependent kinase 1;Cyclin-dependent kinase inhibitor 1	TP53;CDK1;CDKN1A	P53;CDC2 CDC28A CDKN1 P34CDC2;CAP20 CDKN1 CIP1 MDA6 PIC1 SDI1 WAF1
6301	tRNA Splicing Ligase Complex	Human	None	HeLa cells	Q52LJ0;Q92499;Q9BVC5;Q9Y224;Q9Y3I0	283742;1653;79074;51637;51493	MI:0019-coimmunoprecipitation;MI:0071-molecular sieving	GO:0072669;GO:0000394	tRNA-splicing ligase complex;RNA splicing, via endonucleolytic cleavage and ligation	None	None	21311021	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein FAM98B;ATP-dependent RNA helicase DDX1;Ashwin;RNA transcription, translation and transport factor protein;RNA-splicing ligase RtcB homolog	FAM98B;DDX1;C2orf49;RTRAF;RTCB	None;None;None;C14orf166;C22orf28
6302	B-WICH complex	Human	None	HeLa cells	O00159;O60264;O75533;P35659;Q03468;Q9BQG0;Q9C093;Q9NR30;Q9UIG0	4641;8467;23451;7913;2074;10514;79925;9188;9031	MI:0019-coimmunoprecipitation;MI:0071-molecular sieving;MI:0226-ion exchange chromatography	GO:0006351;GO:0005634;GO:0006338	DNA-templated transcription;nucleus;chromatin remodeling	11;70.10	TRANSCRIPTION;nucleus	16603771	None	None	Interactions in the B-WICH complex depend on RNA and active transcription. U1 small nuclear ribonucleoprotein 1 SNRP homolog protein was nor available at the time of annotation.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Unconventional myosin-Ic;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5;Splicing factor 3B subunit 1;Protein DEK;DNA excision repair protein ERCC-6;Myb-binding protein 1A;Sperm flagellar protein 2;Nucleolar RNA helicase 2;Tyrosine-protein kinase BAZ1B	MYO1C;SMARCA5;SF3B1;DEK;ERCC6;MYBBP1A;SPEF2;DDX21;BAZ1B	None;SNF2H, WCRF135;SAP155;None;CSB;P160;KIAA1770 KPL2;None;WBSC10 WBSCR10 WBSCR9 WSTF
6303	DDX11-RAD21-SMC1A-SMC3 complex	Human	None	HeLa cells	O60216;Q14683;Q96FC9;Q9UQE7	5885;8243;1663;9126	MI:0019-coimmunoprecipitation	GO:0007062	sister chromatid cohesion	None	None	17105772	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Double-strand-break repair protein rad21 homolog;Structural maintenance of chromosomes protein 1A;ATP-dependent DNA helicase DDX11;Structural maintenance of chromosomes protein 3	RAD21;SMC1A;DDX11;SMC3	HR21 KIAA0078 NXP1 SCC1;DXS423E KIAA0178 SB1.8 SMC1 SMC1L1;CHL1 CHLR1 KRG2;BAM BMH CSPG6 SMC3L1
6304	DDX11-Ctf18-RFC complex	Human	None	HEK 293 cells	O75717;P12004;Q5FWF5;Q8WVB6;Q96FC9;Q9BVC3	11169;5111;114799;63922;1663;79075	MI:0019-coimmunoprecipitation	GO:0004386;GO:0007062	helicase activity;sister chromatid cohesion	None	None	18499658	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	WD repeat and HMG-box DNA-binding protein 1;Proliferating cell nuclear antigen;N-acetyltransferase ESCO1;Chromosome transmission fidelity protein 18 homolog;ATP-dependent DNA helicase DDX11;Sister chromatid cohesion protein DCC1	WDHD1;PCNA;ESCO1;CHTF18;DDX11;DSCC1	AND1;None;EFO1 KIAA1911;C16orf41 CTF18;CHL1 CHLR1 KRG2;DCC1
6306	DDX27-PeBoW complex	Human	None	RajiB-cells; U2OS cells	O00541;Q14137;Q96GQ7;Q9GZL7	23481;23246;55661;55759	MI:0019-coimmunoprecipitation	GO:0006364;GO:0005730	rRNA processing;nucleolus	11.04.01;70.10.07	rRNA processing;nucleolus	25825154	Knockdown of DDX27 impairs processing of 47S rRNA.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Pescadillo homolog;Ribosome biogenesis protein BOP1;Probable ATP-dependent RNA helicase DDX27;Ribosome biogenesis protein WDR12	PES1;BOP1;DDX27;WDR12	None;KIAA0124;RHLP cPERP-F;None
6307	RAB27A-SLP3-KLC1 transport complex	Human	None	293T cells	P51159;Q07866;Q4VX76	5873;3831;94120	MI:0007-anti tag coimmunoprecipitation	GO:0043316	cytotoxic T cell degranulation	None	None	22308290	Inhibition of the Rab27a/Slp3/kinesin-1 transport compleximpairs lytic granule secretion. This multiprotein complex enables lytic granules to reach the plasma membrane and is thus essential for their release into the IS (immune synapse).	Rab27a deficiency is associated with impaired cytotoxic activity, unbalanced expansion, and activation of CD8 T lymphocytes and the uncontrolled macrophage activation that characterizes Griscelli syndrome type 2.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Ras-related protein Rab-27A;Kinesin light chain 1;Synaptotagmin-like protein 3	RAB27A;KLC1;SYTL3	RAB27;KLC KNS2;SLP3
6308	protein complex (DDX28; DHX30; GRSF1; FASTKD2; FASTKD5)	Human	None	143B cells	Q12849;Q7L2E3;Q7L8L6;Q9NUL7;Q9NYY8	2926;22907;60493;55794;22868	MI:0019-coimmunoprecipitation	GO:0061668	mitochondrial ribosome assembly	None	None	25683715	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	G-rich sequence factor 1;ATP-dependent RNA helicase DHX30;FAST kinase domain-containing protein 5, mitochondrial;Probable ATP-dependent RNA helicase DDX28;FAST kinase domain-containing protein 2, mitochondrial	GRSF1;DHX30;FASTKD5;DDX28;FASTKD2	None;DDX30 KIAA0890;KIAA1792;MDDX28;KIAA0971
6310	DEAF1- complex	Human	None	HEK 293T/17 cells; CV1 cells	O75398;P12956;P13010	10522;2547;7520	MI:0007-anti tag coimmunoprecipitation	GO:0005634	nucleus	70.10	nucleus	22442688	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Deformed epidermal autoregulatory factor 1 homolog;X-ray repair cross-complementing protein 6;X-ray repair cross-complementing protein 5	DEAF1;XRCC6;XRCC5	SPN ZMYND5;G22P1;G22P2
6313	AATF-NGDN-NOL10 complex	Human	ANN complex	HeLa cells	Q8NEJ9;Q9BSC4;Q9NY61	25983;79954;26574	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0090069	regulation of ribosome biogenesis	None	None	27599843	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Neuroguidin;Nucleolar protein 10;Protein AATF	NGDN;NOL10;AATF	C14orf120;;CHE1 DED
6314	MSP58-RINT1 complex	Human	None	None	Q6NUQ1;Q96EZ8	60561;10445	MI:0018-two hybrid	GO:0090069	regulation of ribosome biogenesis	None	None	27530925	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	RAD50-interacting protein 1;Microspherule protein 1	RINT1;MCRS1	None;INO80Q MSP58
6317	NLRP1 inflammasome (CASP5)	Human	NALP1 inflammasome	THP-1 cell	P29466;P51878;Q9C000;Q9ULZ3	834;838;22861;29108	MI:0019-coimmunoprecipitation	GO:0045087;GO:0002221;GO:0072558;GO:0032731;GO:0050729;GO:0051607;GO:0043331;GO:0032496;GO:0061702;GO:0140447;GO:0140639	innate immune response;pattern recognition receptor signaling pathway;NLRP1 inflammasome complex;positive regulation of interleukin-1 beta production;positive regulation of inflammatory response;defense response to virus;response to dsRNA;response to lipopolysaccharide;inflammasome complex;cytokine precursor processing;positive regulation of pyroptosis	36.25.16.01	innate immune response (invertebrates and vertebrates)	12191486	PYCARD recruits CASP1 and the C-terminal CARD domain of NALP1 recruits and activates CASP5. (PMID:15030775)	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Caspase-1;Caspase-5;NACHT, LRR and PYD domains-containing protein 1;Apoptosis-associated speck-like protein containing a CARD	CASP1;CASP5;NLRP1;PYCARD	IL1BC, IL1BCE;ICH3;CARD7 DEFCAP KIAA0926 NAC NALP1;ASC CARD5 TMS1
6321	DLG4-DLGAP1-SHANK3 complex	Human	None	HEK cells	O14490;P78352;Q9BYB0	9229;1742;85358	MI:0019-coimmunoprecipitation	None	None	None	None	10527873	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Disks large-associated protein 1;Disks large homolog 4;SH3 and multiple ankyrin repeat domains protein 3	DLGAP1;DLG4;SHANK3	DAP1 GKAP;PSD95;KIAA1650 PROSAP2 PSAP2
6323	Cardinal-NLRP3 inflammasome	Human	CARD8-NLRP3-PYCARD-CASP1 complex; Cardinal-NALP3 inflammasome	THP-1 cell	P29466;Q96P20;Q9ULZ3;Q9Y2G2	834;114548;29108;22900	MI:0007-anti tag coimmunoprecipitation	GO:0045087;GO:0002221;GO:0072559;GO:0032731;GO:0032692;GO:0050727;GO:0006952;GO:0061702;GO:0140447	innate immune response;pattern recognition receptor signaling pathway;NLRP3 inflammasome complex;positive regulation of interleukin-1 beta production;negative regulation of interleukin-1 production;regulation of inflammatory response;defense response;inflammasome complex;cytokine precursor processing	36.25.16.01	innate immune response (invertebrates and vertebrates)	15030775	The association of Cardinal (CARD8) protein with NLRP3 and its function in the inflammasome is controversially discussed. (PMID:24517500, 15030775)	Increased NLRP3 inflammasome activity is responsible for Muckle-Wells autoinflammatory disorder (PMID:15030775). Aberrant activation of the NLRP3 inflammasome has been linked with several inflammatory disorders, which include cryopyrin-associated periodic syndromes, Alzheimer's disease, diabetes, and atherosclerosis. (PMID:31284572)	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Caspase-1;NACHT, LRR and PYD domains-containing protein 3;Apoptosis-associated speck-like protein containing a CARD;Caspase recruitment domain-containing protein 8	CASP1;NLRP3;PYCARD;CARD8	IL1BC, IL1BCE;C1orf7 CIAS1 NALP3 PYPAF1;ASC CARD5 TMS1;DACAR KIAA0955 NDPP1
6324	Cardinal-NLRP2 inflammasome	Human	NALP2 inflammasome; CARD8-NLRP2-PYCARD-CASP1 complex	THP-1 cell	P29466;Q9NX02;Q9ULZ3;Q9Y2G2	834;55655;29108;22900	MI:0007-anti tag coimmunoprecipitation	GO:0045087;GO:0061702;GO:0050729;GO:0032731;GO:0002221;GO:0006952;GO:0140447	innate immune response;inflammasome complex;positive regulation of inflammatory response;positive regulation of interleukin-1 beta production;pattern recognition receptor signaling pathway;defense response;cytokine precursor processing	36.25.16.01	innate immune response (invertebrates and vertebrates)	15030775	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Caspase-1;NACHT, LRR and PYD domains-containing protein 2;Apoptosis-associated speck-like protein containing a CARD;Caspase recruitment domain-containing protein 8	CASP1;NLRP2;PYCARD;CARD8	IL1BC, IL1BCE;NALP2 NBS1 PAN1 PYPAF2;ASC CARD5 TMS1;DACAR KIAA0955 NDPP1
6332	Elongator complex (ELP1, ELP2, ELP3, ELP4, ELP5, ELP6)	Human	ELP1-ELP2-ELP3-ELP4-ELP5-ELP6 complex	HEK-293 cells	O95163;Q0PNE2;Q6IA86;Q8TE02;Q96EB1;Q9H9T3	8518;54859;55250;23587;26610;55140	MI:0019-coimmunoprecipitation	GO:0006357	regulation of transcription by RNA polymerase II	None	None	22854966	None	OMIM:117100  Centrotemporal epilepsy (PMID:19172991).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Elongator complex protein 1;Elongator complex protein 6;Elongator complex protein 2;Elongator complex protein 5;Elongator complex protein 4;Elongator complex protein 3	ELP1;ELP6;ELP2;ELP5;ELP4;ELP3	IKAP IKBKAP;ATP1 C3orf75 TMEM103;STATIP1;C17orf81 DERP6;C11orf19 PAXNEB;None
6333	Nav1.2-beta2 complex	Human	SCN2A-SCN2B complex	None	O60939;Q99250	6327;6326	MI:0114-x-ray crystallography	None	None	None	None	26894959	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Sodium channel subunit beta-2;Sodium channel protein type 2 subunit alpha	SCN2B;SCN2A	;NAC2 SCN2A1 SCN2A2
6334	Afadin-beta-catenin complex	Human	AFDN-CTNNB1 complex	Mesaglial cells	P35222;P55196	1499;4301	MI:0019-coimmunoprecipitation	GO:0098609;GO:0034332	cell-cell adhesion;adherens junction organization	None	None	26568295	None	Mesangial proliferative nephritis, glomerulonephritis (PMID:26568295).	None	Homo sapiens (Human);Homo sapiens (Human)	Catenin beta-1;Afadin	CTNNB1;AFDN	CTNNB;AF6 MLLT4
6336	CTNNB1-DNMT1 complex	Human	None	HC-116 cells	P26358;P35222	1786;1499	MI:0069-mass spectrometry studies of complexes	GO:0030111;GO:0006306	regulation of Wnt signaling pathway;DNA methylation	10.01.09.01	DNA methylation	25753001	None	Colorectal cancer (PMID:25753001).	None	Homo sapiens (Human);Homo sapiens (Human)	DNA;Catenin beta-1	DNMT1;CTNNB1	AIM CXXC9 DNMT;CTNNB
6337	Amot-cadherin-11-beta-catenin-p120 complex	Human	AMOT-CDH11-CTNNB1-CTNND1 complex	HEK-293T cells	O60716;P35222;P55287;Q4VCS5	1500;1499;1009;154796	MI:0096-pull down	GO:0030334	regulation of cell migration	None	None	25466890	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Catenin delta-1;Catenin beta-1;Cadherin-11;Angiomotin	CTNND1;CTNNB1;CDH11;AMOT	KIAA0384;CTNNB;None;KIAA1071
6339	beta-catenin-B-cell lymphoma 9 protein  complex	Human	CTNNB1-BCL9 complex	None	O00512;P35222	607;1499	MI:0051-fluorescence technology	GO:0030111	regulation of Wnt signaling pathway	None	None	25312469	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	B-cell CLL/lymphoma 9 protein;Catenin beta-1	BCL9;CTNNB1	None;CTNNB
6340	PITX2-MLL4-ASH2L-RBBP5-PTIP complex	Human	None	HEK 293 cells	O14686;Q15291;Q6ZW49;Q99697;Q9UBL3	8085;5929;22976;5308;9070	MI:0019-coimmunoprecipitation	GO:0045595	regulation of cell differentiation	None	None	24486544	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone-lysine N-methyltransferase 2D;Retinoblastoma-binding protein 5;PAX-interacting protein 1;Pituitary homeobox 2;Set1/Ash2 histone methyltransferase complex subunit ASH2	KMT2D;RBBP5;PAXIP1;PITX2;ASH2L	ALR MLL2 MLL4;RBQ3;PAXIP1L PTIP;ARP1 RGS RIEG RIEG1;ASH2L1
6341	GIT1-ARHGEF7-PAK1-PXN complex	Human	PAK1-betaPIX-GIT1-paxillin complex; PAK1-ARHGEF7-GIT1-PXN complex	None	P49023;Q13153;Q14155;Q9Y2X7	5829;5058;8874;28964	MI:0019-coimmunoprecipitation	None	None	None	None	16944954	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Paxillin;Serine/threonine-protein kinase PAK 1;Rho guanine nucleotide exchange factor 7;ARF GTPase-activating protein GIT1	PXN;PAK1;ARHGEF7;GIT1	None;None;COOL1 KIAA0142 P85SPR PAK3BP PIXB;None
6342	JADE1-NPHP4 complex	Human	None	HEK293T cells	O75161;Q6IE81	261734;79960	MI:0019-coimmunoprecipitation	GO:0030178;GO:0097546	negative regulation of Wnt signaling pathway;ciliary base	None	None	22654112	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Nephrocystin-4;Protein Jade-1	NPHP4;JADE1	KIAA0673;KIAA1807 PHF17
6343	SETD7-YAP-AXIN1-beta-catenin complex	Human	SETD7-YAP1-AXIN1-CTNNB1 complex	HEK-293T cells	O15169;P35222;P46937;Q8WTS6	8312;1499;10413;80854	MI:0019-coimmunoprecipitation	GO:0030111;GO:0035330	regulation of Wnt signaling pathway;regulation of hippo signaling	None	None	27046831	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Axin-1;Catenin beta-1;Transcriptional coactivator YAP1;Histone-lysine N-methyltransferase SETD7	AXIN1;CTNNB1;YAP1;SETD7	AXIN;CTNNB;YAP65;KIAA1717 KMT7 SET7 SET9
6344	TNFR1 signaling complex, native	Human	native TNF-RSC; native TNF-R1 signaling complex; TNFR1-associated signaling complex	U937 cell line	O14920;O15111;O43318;P01375;P19438;Q12933;Q13489;Q13546;Q15025;Q15628;Q15750;Q96EP0;Q9BYM8;Q9NYJ8;Q9Y6K9	3551;1147;6885;7124;7132;7186;330;8737;10318;8717;10454;55072;10616;23118;8517	MI:0676-tandem affinity purification	GO:0006954;GO:0016567;GO:0051092;GO:0046328;GO:0042981;GO:0010803	inflammatory response;protein ubiquitination;positive regulation of NF-kappaB transcription factor activity;regulation of JNK cascade;regulation of apoptotic process;regulation of tumor necrosis factor-mediated signaling pathway	36.25.16.07;14.07.05	inflammatory response;modification by ubiquitination, deubiquitination	20005846	Recruitment of the Linear Ubiquitin Chain Assembly Complex (LUBAC) stabilizes the TNF-R1signaling complex and is required for TNF-mediated gene induction.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Inhibitor of nuclear factor kappa-B kinase subunit beta;Inhibitor of nuclear factor kappa-B kinase subunit alpha;Mitogen-activated protein kinase kinase kinase 7;Tumor necrosis factor;Tumor necrosis factor receptor superfamily member 1A;TNF receptor-associated factor 2;Baculoviral IAP repeat-containing protein 3;Receptor-interacting serine/threonine-protein kinase 1;TNFAIP3-interacting protein 1;Tumor necrosis factor receptor type 1-associated DEATH domain protein;TGF-beta-activated kinase 1 and MAP3K7-binding protein 1;E3 ubiquitin-protein ligase RNF31;RanBP-type and C3HC4-type zinc finger-containing protein 1;TGF-beta-activated kinase 1 and MAP3K7-binding protein 2;NF-kappa-B essential modulator	IKBKB;CHUK;MAP3K7;TNF;TNFRSF1A;TRAF2;BIRC3;RIPK1;TNIP1;TRADD;TAB1;RNF31;RBCK1;TAB2;IKBKG	IKKB;IKKA TCF16;TAK1;TNFA TNFSF2;TNFAR, TNFR1;TRAP3;API2 MIHC RNF49;RIP, RIP1;KIAA0113 NAF1;None;MAP3K7IP1;ZIBRA;C20orf18 RNF54 UBCE7IP3 XAP3 XAP4;KIAA0733, MAP3K7IP2;FIP3, NEMO
6345	ZNF304-corepressor complex	Human	None	DLD-1 cells	P26358;Q13263;Q15047;Q9HCX3	1786;10155;9869;57343	MI:0402-chromatin immunoprecipitation assay	GO:0006306;GO:0003677;GO:0005634;GO:0090309	DNA methylation;DNA binding;nucleus;positive regulation of DNA methylation-dependent heterochromatin formation	10.01.09.01;16.03.01;70.10	DNA methylation;DNA binding;nucleus	24623306	Promoter-bound ZNF304 recruits a corepressor complex that includes the DNA methyltransferase DNMT1, resulting in DNAhypermethylation and transcriptional silencing.	The ZNF304-corepressor complex is involved in colorectal cancer. ZNF304 is a protein that binds to stretches of DNA, including regions of DNA at the start of several tumor suppressor genes, and it recruits the enzymes that add the chemical marks that switch off these genes.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA;Transcription intermediary factor 1-beta;Histone-lysine N-methyltransferase SETDB1;Zinc finger protein 304	DNMT1;TRIM28;SETDB1;ZNF304	AIM CXXC9 DNMT;KAP1 RNF96 TIF1B;ESET KIAA0067 KMT1E;None
6347	TNF-TNFR1-TRADD-RIP1-TRAF2 complex	Human	TNFR1 signaling sub-complex	HEK293 cell line	P01375;P19438;Q12933;Q13546;Q15628	7124;7132;7186;8737;8717	MI:0019-coimmunoprecipitation	GO:0051092;GO:0033209;GO:0005886	positive regulation of NF-kappaB transcription factor activity;tumor necrosis factor-mediated signaling pathway;plasma membrane	70.02	eukaryotic plasma membrane / membrane attached	8612133	TNF binds to its receptor TNFR1. TRADD recruits TRAF2 and RIPK1 simultaneously to TNFR1 via its N-terminal TRAF-interacting domain and C-terminal death domain, respectively.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Tumor necrosis factor;Tumor necrosis factor receptor superfamily member 1A;TNF receptor-associated factor 2;Receptor-interacting serine/threonine-protein kinase 1;Tumor necrosis factor receptor type 1-associated DEATH domain protein	TNF;TNFRSF1A;TRAF2;RIPK1;TRADD	TNFA TNFSF2;TNFAR, TNFR1;TRAP3;RIP, RIP1;None
6351	PKP1-ZO-1 complex	Human	None	cervical-loop derived dental epithelium cells	Q07157;Q13835	7082;5317	MI:0019-coimmunoprecipitation	GO:0007155;GO:0042481;GO:0036305	cell adhesion;regulation of odontogenesis;ameloblast differentiation	34.07	cell adhesion	27015268	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Tight junction protein ZO-1;Plakophilin-1	TJP1;PKP1	ZO1;None
6352	FoxM1-Axin-GSK3beta complex	Human	FOXM1-AXIN1-GSK3B complex	LN-229 cells	O15169;P49841;Q08050	8312;2932;2305	MI:0019-coimmunoprecipitation	None	None	None	None	26912724	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Axin-1;Glycogen synthase kinase-3 beta;Forkhead box protein M1	AXIN1;GSK3B;FOXM1	AXIN;None;FKHL16 HFH11 MPP2 WIN
6354	Sox4-beta-catenin-p300 complex	Human	SOX4-CTNNB1-EP300 complex	Ishikawa cells, Hec-251 cells, Hec6 cells	P35222;Q06945;Q09472	1499;6659;2033	MI:0019-coimmunoprecipitation	GO:0051091	positive regulation of DNA-binding transcription factor activity	None	None	26841870	None	Uterine carcinosarcoma (PMID:26841870).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Catenin beta-1;Transcription factor SOX-4;Histone acetyltransferase p300	CTNNB1;SOX4;EP300	CTNNB;;P300
6355	Glutamate receptor 1 complex, metabotropic	Human	None	COS-7 cells	Q13255	2911	MI:0055-fluorescent resonance energy transfer	GO:0008066	glutamate receptor activity	None	None	20826542	None	None	None	Homo sapiens (Human)	Metabotropic glutamate receptor 1	GRM1	GPRC1A MGLUR1
6356	Glutamate receptor 2 complex, metabotropic	Human	None	COS-7 cells	Q14416	2912	MI:0055-fluorescent resonance energy transfer	GO:0008066	glutamate receptor activity	None	None	20826542	None	None	None	Homo sapiens (Human)	Metabotropic glutamate receptor 2	GRM2	GPRC1B MGLUR2
6357	Glutamate receptor 4 complex, metabotropic	Human	None	COS-7 cells	Q14833	2914	MI:0055-fluorescent resonance energy transfer	GO:0008066	glutamate receptor activity	None	None	20826542	None	None	None	Homo sapiens (Human)	Metabotropic glutamate receptor 4	GRM4	GPRC1D MGLUR4
6358	Glutamate receptor 7 complex, metabotropic	Human	None	COS-7 cells	Q14831	2917	MI:0055-fluorescent resonance energy transfer	GO:0008066	glutamate receptor activity	None	None	20826542	None	None	None	Homo sapiens (Human)	Metabotropic glutamate receptor 7	GRM7	GPRC1G MGLUR7
6359	RHAMM-beta-catenin complex	Human	None	HT-1080 cell	O75330;P35222	3161;1499	MI:0019-coimmunoprecipitation	GO:0042127	regulation of cell population proliferation	None	None	26825774	None	Fibrosarcoma (PMID:26825774).	None	Homo sapiens (Human);Homo sapiens (Human)	Hyaluronan mediated motility receptor;Catenin beta-1	HMMR;CTNNB1	IHABP; RHAMM;CTNNB
6360	Glutamate receptor 8 complex, metabotropic	Human	None	COS-7 cells	O00222	2918	MI:0055-fluorescent resonance energy transfer	GO:0008066	glutamate receptor activity	None	None	20826542	None	None	None	Homo sapiens (Human)	Metabotropic glutamate receptor 8	GRM8	GPRC1H MGLUR8
6362	PDLIM1-E-cadherin-beta-catenin complex	Human	PDLIM1-CDH1-CTNNB1 complex	None	O00151;P12830;P35222	9124;999;1499	MI:0019-coimmunoprecipitation	GO:0061635	regulation of protein complex stability	None	None	26701804	None	Colorectal cancer (PMID:26701804).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	PDZ and LIM domain protein 1;Cadherin-1;Catenin beta-1	PDLIM1;CDH1;CTNNB1	CLIM1 CLP36;CDHE UVO;CTNNB
6363	mGluR2-mGluR4 complex	Human	None	HEK cells	Q14416;Q14833	2912;2914	MI:0019-coimmunoprecipitation	GO:0008066	glutamate receptor activity	None	None	24381270	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Metabotropic glutamate receptor 2;Metabotropic glutamate receptor 4	GRM2;GRM4	GPRC1B MGLUR2;GPRC1D MGLUR4
6364	OVOL2-beta-catenin-TCF4 complex	Human	None	LS174T cells	P15884;P35222;Q9BRP0	6925;1499;58495	MI:0019-coimmunoprecipitation	GO:0060828	regulation of canonical Wnt signaling pathway	None	None	26619963	None	Colorectal cancer (PMID:26619963).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transcription factor 4;Catenin beta-1;Transcription factor Ovo-like 2	TCF4;CTNNB1;OVOL2	BHLHB19 ITF2 SEF2;CTNNB;ZNF339
6365	Synexin-sorcin complex	Human	ANX7-SRI complex	human proteins expressed in yeast	P20073;P30626	310;6717	MI:0004-affinity chromatography technology;MI:0047-far western blotting	GO:0042583;GO:0042584;GO:0048306	chromaffin granule;chromaffin granule membrane;calcium-dependent protein binding	None	None	9268363	Synexin (annexin VII) forms a complex with sorcin and recruits this protein to chromaffin granule membranes in a Ca2+-dependent manner. Sorcin is able to inhibit synexin-mediated chromaffin granule aggregation in a manner saturable with increasing sorcin concentrations, but does not influence the Ca2+ sensitivity of synexin-mediated granule aggregation. Therefore, the interaction between sorcin and synexin may serve to regulate the functions of these proteins on membrane surfaces in a Ca2+-dependent manner. Overlay assays using deletion constructs of the synexin N-terminal domain mapped the sorcin binding site to the N-terminal 31 amino acids of the synexin protein. Affinity chromatography identified sorcin as a Ca2+-dependent synexin-binding protein.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Annexin A7;Sorcin	ANXA7;SRI	ANX7 SNX;None
6367	mGluR2-mGluR7 complex	Human	None	COS-7 cells	Q14416;Q14831	2912;2917	MI:0055-fluorescent resonance energy transfer	GO:0008066	glutamate receptor activity	None	None	20826542	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Metabotropic glutamate receptor 2;Metabotropic glutamate receptor 7	GRM2;GRM7	GPRC1B MGLUR2;GPRC1G MGLUR7
6368	mGluR2-mGluR8 complex	Human	None	COS-7 cells	O00222;Q14416	2918;2912	MI:0055-fluorescent resonance energy transfer	GO:0008066	glutamate receptor activity	None	None	20826542	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Metabotropic glutamate receptor 8;Metabotropic glutamate receptor 2	GRM8;GRM2	GPRC1H MGLUR8;GPRC1B MGLUR2
6369	mGluR3-mGluR4 complex	Human	None	COS-7 cells	Q14832;Q14833	2913;2914	MI:0055-fluorescent resonance energy transfer	GO:0008066	glutamate receptor activity	None	None	20826542	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Metabotropic glutamate receptor 3;Metabotropic glutamate receptor 4	GRM3;GRM4	GPRC1C MGLUR3;GPRC1D MGLUR4
6370	mGluR3-mGluR7 complex	Human	None	COS-7 cells	Q14831;Q14832	2917;2913	MI:0055-fluorescent resonance energy transfer	GO:0008066	glutamate receptor activity	None	None	20826542	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Metabotropic glutamate receptor 7;Metabotropic glutamate receptor 3	GRM7;GRM3	GPRC1G MGLUR7;GPRC1C MGLUR3
6371	mGluR3-mGluR8 complex	Human	None	COS-7 cells	O00222;Q14832	2918;2913	MI:0055-fluorescent resonance energy transfer	GO:0008066	glutamate receptor activity	None	None	20826542	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Metabotropic glutamate receptor 8;Metabotropic glutamate receptor 3	GRM8;GRM3	GPRC1H MGLUR8;GPRC1C MGLUR3
6373	MiDAC complex	Human	None	K562 cells	Q13547;Q6PJG2;Q92769;Q9H147	3065;91748;3066;116092	MI:0019-coimmunoprecipitation	None	None	None	None	21258344	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone deacetylase 1;Mitotic deacetylase-associated SANT domain protein;Histone deacetylase 2;Deoxynucleotidyltransferase terminal-interacting protein 1	HDAC1;MIDEAS;HDAC2;DNTTIP1	RPD3L1;C14orf117 C14orf43 ELMSAN1;None;C20orf167 TDIF1
6374	Calcineurin-FKBP12 complex	Human	CaN-FKBP12 complex	human proteins expressed in E.coli	P62942;P63098;Q08209	2280;5534;5530	MI:0114-x-ray crystallography	GO:0019722;GO:0005955;GO:0005516;GO:0016791;GO:0042110	calcium-mediated signaling;calcineurin complex;calmodulin binding;phosphatase activity;T cell activation	30.01.09.03	Ca2+ mediated signal transduction	8524402	Calcineurin (CaN) is a calcium- and calmodulin-dependent protein serine/threonine phosphatase which is critical for several important cellular processes, including T-cell activation. CaN is a heterodimer composed of a catalytic A unit and a regulatory B unit.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Peptidyl-prolyl cis-trans isomerase FKBP1A;Calcineurin subunit B type 1;Protein phosphatase 3 catalytic subunit alpha	FKBP1A;PPP3R1;PPP3CA	FKBP1 FKBP12;CNA2 CNB;CALNA CNA
6375	PEF1-ALG2 complex	Human	PEF1-PDCD6 complex	Jurkat cells	O75340;Q9UBV8	10016;553115	MI:0019-coimmunoprecipitation;MI:0091-chromatography technology	GO:0051592;GO:0005737	response to calcium ion;cytoplasm	70.03	cytoplasm	11278427	Peflin dissociated from ALG-2 in the presence of Ca(2+). Peflin and ALG-2 co-localized in the cytoplasm, but ALG-2 was also detected in the nuclei as revealed by immunofluorescent staining and subcellular fractionation. Peflin was recovered in the cytosolic fraction in the absence of Ca(2+) but in the membrane/cytoskeletal fraction in the presence of Ca(2+). These results suggest that peflin has features common to those of other PEF proteins (dimerization and translocation to membranes) and may modulate the function of ALG-2 in Ca(2+) signaling. Peflin, a Ca(2+)-binding protein, belongs to the penta-EF-hand (PEF) protein family, which includes the calpain small subunit, sorcin, grancalcin, and ALG-2 (apoptosis-linked gene 2).	None	None	Homo sapiens (Human);Homo sapiens (Human)	Programmed cell death protein 6;Peflin	PDCD6;PEF1	ALG2;ABP32
6381	NPHP1-NPHP4-BCAR1 complex	Human	NPHP1-NPHP4-p130Cas complex	HEK293 cells	O15259;O75161;P56945	4867;261734;9564	MI:0019-coimmunoprecipitation	GO:0098609;GO:0007160;GO:0051301	cell-cell adhesion;cell-matrix adhesion;cell division	34.07.02	cell-matrix adhesion	15661758	None	Nephrocystin and nephrocystin-4 are proteins involved in familial juvenile nephronophthisis, an autosomal recessive nephropathy characterized by cyst formation and renal fibrosis.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Nephrocystin-1;Nephrocystin-4;Breast cancer anti-estrogen resistance protein 1	NPHP1;NPHP4;BCAR1	NPH1;KIAA0673;CAS CASS1 CRKAS
6388	CORVET complex	Human	Class C core vacuole/endosome tethering complex; Endosomal tethering complex CORVET	MelJuSo cell	Q8N3P4;Q8WUH2;Q96AX1;Q9H269;Q9H270;Q9P253	23355;9392;65082;64601;55823;57617	MI:0019-coimmunoprecipitation	GO:0033263;GO:0099022;GO:0034058	CORVET complex;vesicle tethering;endosomal vesicle fusion	None	None	26463206	None	Missense mutations in the gene VPS11 are associated with  hypomyelination and developmental delay (PMID:26307567).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Vacuolar protein sorting-associated protein 8 homolog;Transforming growth factor-beta receptor-associated protein 1;Vacuolar protein sorting-associated protein 33A;Vacuolar protein sorting-associated protein 16 homolog;Vacuolar protein sorting-associated protein 11 homolog;Vacuolar protein sorting-associated protein 18 homolog	VPS8;TGFBRAP1;VPS33A;VPS16;VPS11;VPS18	KIAA0804;None;None;None;RNF108;KIAA1475
6389	HOPS complex	Human	Homotypic fusion and vacuole protein sorting complex; Endosomal tethering complex HOPS	MelJuSo cell	P49754;Q96AX1;Q96JC1;Q9H269;Q9H270;Q9P253	27072;65082;23339;64601;55823;57617	MI:0019-coimmunoprecipitation	GO:0099022;GO:0034058;GO:0035542;GO:0019048;GO:0051607;GO:0061909	vesicle tethering;endosomal vesicle fusion;regulation of SNARE complex assembly;modulation by virus of host process;defense response to virus;autophagosome-lysosome fusion	None	None	26463206	The mammalian HOPS complex is recruited to membranes by binding to the RAB7 effector RILP (PMID:26463206). Autophagy is a cellular surveillance mechanism to combat invading pathogens. SARS-CoV-2 protein ORF3 inhibits autophagy by directly interacting with the VPS39 subunit of the HOPS complex, thereby preventing the HOPS complex from interacting with the SNARE protein STX17 required for autolysosome formation. (PMID:33422265)	Missense mutations in the gene VPS11 are associated with hypomyelination and developmental delay (PMID:26307567).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Vacuolar protein sorting-associated protein 41 homolog;Vacuolar protein sorting-associated protein 33A;Vam6/Vps39-like protein;Vacuolar protein sorting-associated protein 16 homolog;Vacuolar protein sorting-associated protein 11 homolog;Vacuolar protein sorting-associated protein 18 homolog	VPS41;VPS33A;VPS39;VPS16;VPS11;VPS18	None;None;KIAA0770 TLP VAM6;None;RNF108;KIAA1475
6390	Endosomal targeting complex (VIPAS39-VPS33B)	Human	VPS33B-VIPAS39 complex	MelJuSo cell	Q9H267;Q9H9C1	26276;63894	MI:0006-anti bait coimmunoprecipitation	GO:0034058;GO:0099022	endosomal vesicle fusion;vesicle tethering	None	None	26463206	None	Autosomal recessive mutations in VPS33B or VIPAS39 cause arthrogryposis-renal dysfunction-cholestasis (ARC) syndrome.	None	Homo sapiens (Human);Homo sapiens (Human)	Vacuolar protein sorting-associated protein 33B;Spermatogenesis-defective protein 39 homolog	VPS33B;VIPAS39	None;C14orf133 SPE39 VIPAR
6391	KCTD12-GNB1-GNG2 complex	Human	None	HEK293T cells	P59768;P62873;Q96CX2	54331;2782;115207	MI:0019-coimmunoprecipitation	GO:0002029	desensitization of G protein-coupled receptor signaling pathway	None	None	24836506	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;BTB/POZ domain-containing protein KCTD12	GNG2;GNB1;KCTD12	None;None;C13orf2 KIAA1778 PFET1
6392	KCTD8-GNB1-GNG2 complex	Human	None	HEK293T cells	P59768;P62873;Q6ZWB6	54331;2782;386617	MI:0019-coimmunoprecipitation	GO:0007186	G protein-coupled receptor signaling pathway	30.05.02.24	G-protein coupled receptor signalling pathway	24836506	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;BTB/POZ domain-containing protein KCTD8	GNG2;GNB1;KCTD8	None;None;None
6393	KCTD16-GNB1-GNG2 complex	Human	None	HEK293T cells	P59768;P62873;Q68DU8	54331;2782;57528	MI:0019-coimmunoprecipitation	GO:0007186	G protein-coupled receptor signaling pathway	30.05.02.24	G-protein coupled receptor signalling pathway	24836506	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;BTB/POZ domain-containing protein KCTD16	GNG2;GNB1;KCTD16	None;None;KIAA1317
6394	CNOT1-CNOT2-CNOT3 complex	Human	None	None	A5YKK6;O75175;Q9NZN8	23019;4849;4848	MI:0114-x-ray crystallography	GO:0006355;GO:0035195;GO:1901873	regulation of DNA-templated transcription;miRNA-mediated gene silencing;regulation of post-translational protein modification	11.02.03.04	transcriptional control	24121232	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	CCR4-NOT transcription complex subunit 1;CCR4-NOT transcription complex subunit 3;CCR4-NOT transcription complex subunit 2	CNOT1;CNOT3;CNOT2	CDC39, KIAA1007, NOT1;KIAA0691 LENG2 NOT3;CDC36 NOT2
6395	4E-T-DDX6-CNOT1 complex	Human	None	None	A5YKK6;P26196;Q9NRA8	23019;1656;56478	MI:0114-x-ray crystallography	GO:0017148;GO:1901834	negative regulation of translation;regulation of deadenylation-independent decapping of nuclear-transcribed mRNA	None	None	26489469	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	CCR4-NOT transcription complex subunit 1;Probable ATP-dependent RNA helicase DDX6;Eukaryotic translation initiation factor 4E transporter	CNOT1;DDX6;EIF4ENIF1	CDC39, KIAA1007, NOT1;HLR2 RCK;None
6396	DNJC3-DNAJB1-HSPA8 complex	Human	P58IPK-HSP40-HSC70 complex	HeLa cells	P11142;P25685;Q13217	3312;3337;5611	MI:0007-anti tag coimmunoprecipitation	GO:0039585	PKR-mediated signaling	None	None	9920933	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Heat shock cognate 71 kDa protein;DnaJ homolog subfamily B member 1;DnaJ homolog subfamily C member 3	HSPA8;DNAJB1;DNAJC3	HSC70 HSP73 HSPA10;DNAJ1 HDJ1 HSPF1;P58IPK PRKRI
6402	NMNAT2-HSP90 complex	Human	None	HEK293-tau cells	P07900;Q9BZQ4	3320;23057	MI:0007-anti tag coimmunoprecipitation	GO:0061077;GO:0042026	chaperone-mediated protein folding;protein refolding	None	None	27254664	Elevating NMNAT2 levels in rTg4510 mice (aFrontotemporal Dementia and Parkinsonism-17 (FTDP-17) tauopathy model) ameliorates their neurodegenerative phenotype. These finding suggest a role for NMNAT2 in neuronal maintenance in the brain, but the mechanism underlying neuroprotection remains to be elucidated.	Brain NMNAT2 mRNA levels correlate positively with global cognitive function and negatively with Alzheimer disease pathology. In Alzheimer disease brains, NMNAT2 mRNA and protein levels are reduced.	None	Homo sapiens (Human);Homo sapiens (Human)	Heat shock protein HSP 90-alpha;Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2	HSP90AA1;NMNAT2	HSP90A HSPC1 HSPCA;C1orf15,KIAA0479
6403	MST1-SAV1 complex	Human	None	293T cells	Q13043;Q9H4B6	6789;60485	MI:0007-anti tag coimmunoprecipitation	GO:0060271	cilium assembly	None	None	16930133	The effect of Mst2 on Sav phosphorylation and stability was almost always greater than that of Mst1, suggesting that Sav is a preferred partner-substrate of Mst2 compared to Mst1. Sav is phosphorylated by Mst and the phosphorylation is likely to be direct.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein kinase 4;Protein salvador homolog 1	STK4;SAV1	KRS2, MST1;WW45
6404	SAV1-STK3 complex	Human	MST2-SAV1 complex	293T cells	Q13188;Q9H4B6	6788;60485	MI:0007-anti tag coimmunoprecipitation	GO:0060271	cilium assembly	None	None	16930133	The effect of Mst2 on Sav phosphorylation and stability was almost always greater than that of Mst1, suggesting that Sav is a preferred partner-substrate of Mst2 compared to Mst1. Sav is phosphorylated by Mst and the phosphorylation is likely to be direct.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein kinase 3;Protein salvador homolog 1	STK3;SAV1	KRS1, MST2;WW45
6405	COX1-MITRAC12-SURF1 complex	Human	COA3-SURF1-MT-CO1 complex	HEK293 cells	P00395;Q15526;Q9Y2R0	4512;6834;28958	MI:0019-coimmunoprecipitation;MI:0276-blue native page	GO:0005739;GO:0005743	mitochondrion;mitochondrial inner membrane	70.16;70.16.05	mitochondrion;mitochondrial inner membrane	23260140	Copurification of MITRAC12 with COX1 and SURF1 suggested a role in early steps of cytochrome c oxidase biogenesis. MITRAC12 is a cytochrome c oxidase assembly factor and required for efficient COX1 translation. Mitochondria from MITRAC12-depleted cells displayed reduced cytochrome c oxidase activity.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cytochrome c oxidase subunit 1;Surfeit locus protein 1;Cytochrome c oxidase assembly factor 3 homolog, mitochondrial	MT-CO1;SURF1;COA3	COI COXI MTCO1;SURF-1;CCDC56 MITRAC12
6410	MITRAC7-COX1 complex	Human	SMIM20-MT-CO1 complex	HEK293T cells; U2OS cells	P00395;Q8N5G0	4512;389203	MI:0019-coimmunoprecipitation;MI:0051-fluorescence technology;MI:0276-blue native page	GO:0005739;GO:1903607;GO:0033617	mitochondrion;cytochrome c biosynthetic process;mitochondrial cytochrome c oxidase assembly	70.16	mitochondrion	26321642	Cytochrome c oxidase, the terminal enzyme of the respiratory chain, is assembled from mitochondria- and nuclear-encoded subunits. The MITRAC complex represents the central assembly intermediate during this process as it receives imported subunits and regulates mitochondrial translation of COX1 mRNA. MITRAC7 is a COX1-specific chaperone that binds newly synthesized COX1 to stabilize the molecule during assembly. Although a lack of MITRAC7 causes turnover of newly synthesized COX1, overabundance of MITRAC7 traps COX1 in the MITRAC assembly intermediate. Hence, MITRAC7 reveals a checkpoint of the cytochrome c oxidase assembly process.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cytochrome c oxidase subunit 1;Small integral membrane protein 20	MT-CO1;SMIM20	COI COXI MTCO1;C4orf52,MITRAC7
6411	TRIM31-MAGEA1-NSE4 complex	Human	TRIM31-MAGEA1-NSMCE4A complex	None	P43355;Q9BZY9;Q9NXX6	4100;11074;54780	MI:0019-coimmunoprecipitation	GO:0006355	regulation of DNA-templated transcription	11.02.03.04	transcriptional control	25590999	None	Melanoma (PMID:25590999).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Melanoma-associated antigen 1;E3 ubiquitin-protein ligase TRIM31;Non-structural maintenance of chromosomes element 4 homolog A	MAGEA1;TRIM31;NSMCE4A	MAGE1 MAGE1A;C6orf13 RNF;C10orf86
6412	AURKA-HDAC6 cilia-disassembly complex	Human	None	293T cells	O14965;Q9UBN7	6790;10013	MI:0019-coimmunoprecipitation	GO:0061523	cilium disassembly	None	None	25367221	Upon receiving a cell-cycle re-entry cue, Aurora kinase A (AURKA) is activated and in turn enhances the activity of HDAC6, an enzyme that deacetylates ciliary tubulin, promoting cilia disassembly.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Aurora kinase A;Histone deacetylase 6	AURKA;HDAC6	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6;KIAA0901
6413	PDGFB-PDGFRB complex	Human	None	in vitro	P01127;P09619	5155;5159	MI:0047-far western blotting	GO:0035791	platelet-derived growth factor receptor-beta signaling pathway	None	None	7679113	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Platelet-derived growth factor subunit B;Platelet-derived growth factor receptor beta	PDGFB;PDGFRB	PDGF2,SIS;PDGFR PDGFR1
6415	pallidin-Cappuccino-BLOS1 complex	Human	BLOC1S6-BLOC1S4-BLOC1S1 subcomplex	None	P78537;Q9NUP1;Q9UL45	2647;55330;26258	MI:0004-affinity chromatography technology	None	None	None	None	22203680	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Biogenesis of lysosome-related organelles complex 1 subunit 1;Biogenesis of lysosome-related organelles complex 1 subunit 4;Biogenesis of lysosome-related organelles complex 1 subunit 6	BLOC1S1;BLOC1S4;BLOC1S6	BLOS1 GCN5L1 RT14;CNO;PA, PLDN
6416	dysbindin-Snapin-BLOS2 complex	Human	DTNBP1-SNAPIN-BLOC1S2 subcomplex	None	O95295;Q6QNY1;Q96EV8	23557;282991;84062	MI:0004-affinity chromatography technology	None	None	None	None	22203680	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	SNARE-associated protein Snapin;Biogenesis of lysosome-related organelles complex 1 subunit 2;Dysbindin	SNAPIN;BLOC1S2;DTNBP1	BLOC1S7 SNAP25BP SNAPAP;BLOS2 CEAP;BLOC1S8
6417	Fibrinogen complex	Human	None	None	P02671;P02675;P02679	2243;2244;2266	MI:0071-molecular sieving;MI:0114-x-ray crystallography	GO:0030168	platelet activation	None	None	19296670	None	Congenital fibrinogen disorders (PMID:).27492693	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Fibrinogen alpha chain;Fibrinogen beta chain;Fibrinogen gamma chain	FGA;FGB;FGG	None;None;None
6418	C1q complex	Human	C1QA-C1QB-C1QC complex	None	P02745;P02746;P02747	712;713;714	MI:0071-molecular sieving	GO:0002376;GO:0006955;GO:0006956;GO:0006958;GO:0045087	immune system process;immune response;complement activation;complement activation, classical pathway;innate immune response	36.25.16;36.25.16.01.01;36.25.16.01	immune response;complement response;innate immune response (invertebrates and vertebrates)	938474	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Complement C1q subcomponent subunit A;Complement C1q subcomponent subunit B;Complement C1q subcomponent subunit C	C1QA;C1QB;C1QC	None;None;C1QG
6421	DNTTIP1-ZNF541-HDAC1-HDAC2 complex	Human	None	HEK293	Q13547;Q92769;Q9H0D2;Q9H147	3065;3066;84215;116092	MI:0007-anti tag coimmunoprecipitation	GO:0000118;GO:0004407	histone deacetylase complex;histone deacetylase activity	None	None	21573134	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone deacetylase 1;Histone deacetylase 2;Zinc finger protein 541;Deoxynucleotidyltransferase terminal-interacting protein 1	HDAC1;HDAC2;ZNF541;DNTTIP1	RPD3L1;None;None;C20orf167 TDIF1
6422	SETDB1-DNMT3A complex	Human	None	COS-7cells	Q15047;Q9Y6K1	9869;1788	MI:0019-coimmunoprecipitation	GO:0017053;GO:0006355	transcription repressor complex;regulation of DNA-templated transcription	11.02.03.04	transcriptional control	16682412	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Histone-lysine N-methyltransferase SETDB1;DNA	SETDB1;DNMT3A	ESET KIAA0067 KMT1E;None
6423	SETDB1-DNMT3B complex	Human	None	COS-7	Q15047;Q9UBC3	9869;1789	MI:0019-coimmunoprecipitation	GO:0006355	regulation of DNA-templated transcription	11.02.03.04	transcriptional control	16682412	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Histone-lysine N-methyltransferase SETDB1;DNA	SETDB1;DNMT3B	ESET KIAA0067 KMT1E;None
6426	ATF4-CREB1 complex	Human	None	HeLa cells	P16220;P18848	1385;468	MI:0071-molecular sieving	GO:0006355	regulation of DNA-templated transcription	11.02.03.04	transcriptional control	12871976	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cyclic AMP-responsive element-binding protein 1;Cyclic AMP-dependent transcription factor ATF-4	CREB1;ATF4	None;CREB2 TXREB
6428	ATL1 homo-oligomer complex	Human	Atlastin-1 homo-oligomer complex; SPG3A homo-oligomer complex	COS-7 cells	Q8WXF7-1	51062	MI:0019-coimmunoprecipitation;MI:0030-cross-linking study;MI:0091-chromatography technology;MI:0397-two hybrid array	GO:0098796	membrane protein complex	None	None	14506257	Yeast two-hybrid analyses and co-immunoprecipitation studies demonstrated that atlastin-1 can self-associate, and gel-exclusion chromatography and chemical cross-linking studies indicated that atlastin-1 exists as an oligomer in vivo, most likely a tetramer. Membrane fractionation and protease protection assays revealed that atlastin-1 is an integral membrane protein with two predicted transmembrane domains; both the N-terminal GTP-binding and C-terminal domains are exposed to the cytoplasm. Together, these findings indicate that the SPG3A protein atlastin-1 is a multimeric integral membrane GTPase that may be involved in Golgi membrane dynamics or vesicle trafficking.	None	ATL1 (558 aa) = splice variant/isoform.	Homo sapiens (Human)	Isoform 1 of Atlastin-1	ATL1	GBP3 SPG3A
6429	SPG3A-SPG4-SPG31 complex	Human	REEP1-ATL1-SPAST complex	in vitro	Q8WXF7;Q9H902;Q9UBP0	51062;65055;6683	MI:0019-coimmunoprecipitation	GO:0008017;GO:0007029	microtubule binding;endoplasmic reticulum organization	42.07	endoplasmic reticulum	20200447	REEP1 interacts with the HSP proteins atlastin-1 and spastin through intramembrane hairpin domains. REEP proteins were required for ER network formation in vitro, and REEP1 also bound microtubules and promoted ER alignment along the microtubule cytoskeleton (PMID:20200447).	Hereditary spastic paraplegias (HSP)	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Atlastin-1;Receptor expression-enhancing protein 1;Spastin	ATL1;REEP1;SPAST	GBP3, SPG3A;C2orf23 SPG31;ADPSP FSP2 KIAA1083 SPG4
6430	ATL2-SPG31 complex	Human	REEP1-ATL2 complex	in vitro	Q8NHH9;Q9H902	64225;65055	MI:0019-coimmunoprecipitation	GO:0007029;GO:0008017	endoplasmic reticulum organization;microtubule binding	42.07	endoplasmic reticulum	20200447	REEP1 coimmunoprecipitated with the human atlastin family members, atlastin-1, atlastin-2 and atlastin-3. ATL2 and ATL3 are highly similar to ATL1 in the membrane-spanning regions but divergent in the cytoplasmic C terminus.	Hereditary spastic paraplegias (PMID:19034539).	None	Homo sapiens (Human);Homo sapiens (Human)	Atlastin-2;Receptor expression-enhancing protein 1	ATL2;REEP1	ARL6IP2;C2orf23 SPG31
6431	ATL3-SPG31 complex	Human	ATL3-REEP1 complex	in vitro	Q6DD88;Q9H902	25923;65055	MI:0019-coimmunoprecipitation	GO:0007029;GO:0008017	endoplasmic reticulum organization;microtubule binding	42.07	endoplasmic reticulum	20200447	REEP1 coimmunoprecipitated with the human atlastin family members, atlastin-1, atlastin-2 and atlastin-3. ATL2 and ATL3 are highly similar to ATL1 in the membrane-spanning regions but divergent in the cytoplasmic C terminus.	Hereditary spastic paraplegias	None	Homo sapiens (Human);Homo sapiens (Human)	Atlastin-3;Receptor expression-enhancing protein 1	ATL3;REEP1	None;C2orf23 SPG31
6432	TTN-TCAP complex	Human	None	None	O15273;Q8WZ42	8557;7273	MI:0428-imaging technique	GO:0045214;GO:0055013;GO:0055003;GO:0030049	sarcomere organization;cardiac muscle cell development;cardiac myofibril assembly;muscle filament sliding	None	None	19622741	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Telethonin;Titin	TCAP;TTN	None;None
6434	MIS18 complex	Human	MIS18A-OIP5-MIS18BP1 complex	HeLa cells	O43482;Q6P0N0;Q9NYP9	11339;55320;54069	MI:0019-coimmunoprecipitation	GO:0043505	CENP-A containing nucleosome	None	None	17199038	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein Mis18-beta;Mis18-binding protein 1;Protein Mis18-alpha	OIP5;MIS18BP1;MIS18A	MIS18B;C14orf106 KIAA1903 KNL2 M18BP1;C21orf45,C21orf46,FASP1
6435	HAUS augmin-like complex	Human	HAUS1-HAUS2-HAUS3-HAUS4-HAUS5-HAUS6-HAUS7-HAUS8 complex	HeLa cells	O94927;Q68CZ6;Q7Z4H7;Q96CS2;Q99871;Q9BT25;Q9H6D7;Q9NVX0	23354;79441;54801;115106;55559;93323;54930;55142	MI:0004-affinity chromatography technology;MI:0019-coimmunoprecipitation;MI:0069-mass spectrometry studies of complexes	GO:0000086;GO:0000278;GO:0007098	G2/M transition of mitotic cell cycle;mitotic cell cycle;centrosome cycle	10.03.01.01.09;10.03.01.01;10.03.05.01	G2/M transition of mitotic cell cycle;mitotic cell cycle;spindle pole body/centrosome and microtubule cycle	19427217	HAUS localizes to interphase centrosomes and to mitotic spindle microtubules, and its disruption induces microtubule-dependent fragmentation of centrosomes along with an increase in centrosome size. HAUS disruption results in the destabilization of kinetochore microtubules and the eventual formation of multipolar spindles. These severe mitotic defects are alleviated by codepletion of NuMA, indicating that both factors regulate opposing activities. HAUS disruption alters NuMA localization, suggesting that mislocalized NuMA activity contributes to the spindle and centrosome defects observed.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	HAUS augmin-like complex subunit 5;HAUS augmin-like complex subunit 3;HAUS augmin-like complex subunit 6;HAUS augmin-like complex subunit 1;HAUS augmin-like complex subunit 7;HAUS augmin-like complex subunit 8;HAUS augmin-like complex subunit 4;HAUS augmin-like complex subunit 2	HAUS5;HAUS3;HAUS6;HAUS1;HAUS7;HAUS8;HAUS4;HAUS2	KIAA0841;C4orf15;DGT6 FAM29A KIAA1574;CCDC5 HEIC;UCHL5IP,UIP1;HICE1;C14orf94;C15orf25,CEP27
6436	ATP4A-ATP4B complex	Human	None	None	P20648;P51164	495;496	MI:0004-affinity chromatography technology;MI:0069-mass spectrometry studies of complexes	GO:0071805	potassium ion transmembrane transport	None	None	17255364	None	Familial gastric neuroendocrine tumors (PMID:27491072).	None	Homo sapiens (Human);Homo sapiens (Human)	Potassium-transporting ATPase alpha chain 1;Potassium-transporting ATPase subunit beta	ATP4A;ATP4B	None;None
6438	SCNN1A-SCNN1B-SCNN1G complex	Human	None	in vitro	P37088;P51168;P51170	6337;6338;6340	MI:0013-biophysical	GO:0006814	sodium ion transport	None	None	7499195	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Amiloride-sensitive sodium channel subunit alpha;Amiloride-sensitive sodium channel subunit beta;Amiloride-sensitive sodium channel subunit gamma	SCNN1A;SCNN1B;SCNN1G	SCNN1;None;None
6439	SCNN1B-SCNN1G-SCNN1D complex	Human	None	None	P51168;P51170;P51172	6338;6340;6339	MI:0019-coimmunoprecipitation	GO:0006814	sodium ion transport	None	None	16423824	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Amiloride-sensitive sodium channel subunit beta;Amiloride-sensitive sodium channel subunit gamma;Amiloride-sensitive sodium channel subunit delta	SCNN1B;SCNN1G;SCNN1D	None;None;DNACH
6440	CHRNA2-CHRNB4 complex	Human	nAChR complex (alpha2, beta4)	Thalamus	P30926;Q15822	1143;1135	MI:0045-experimental interaction detection	GO:0007271;GO:0035094;GO:0007274	synaptic transmission, cholinergic;response to nicotine;neuromuscular synaptic transmission	None	None	8906617	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Neuronal acetylcholine receptor subunit beta-4;Neuronal acetylcholine receptor subunit alpha-2	CHRNB4;CHRNA2	None;None
6441	KIAA0753-FOR20-OFD1 complex	Human	OFIP-FOR20-OFD1 complex	HeLa Kyoto cells; RPE1 cells (immortalized human retinal pigment epithelial cells htert-RPE1); Cos1	O75665;Q2KHM9;Q96NB1	8481;9851;123811	MI:0019-coimmunoprecipitation;MI:0416-fluorescence microscopy	GO:0060271;GO:0034451;GO:0032053	cilium assembly;centriolar satellite;ciliary basal body organization	None	None	26643951	Depletion of individual proteins of the complex affectscentrosomes, PSs (pericentriolar satellites) and ciliogenesis.	The OFIP-OFD1-FOR20 complex is defective in a patient with oral-facial-digital (OFD) syndromes. Heterozygous mutations of KIAA0753/OFIP in a patientwith an OFD VI syndrome have been analyzed.. The patient cells showed a strong reduction of FOR20 and OFD1 at the centrosome and PSs (pericentriolar satellites).	The central region of KIAA0753 (OFIP) stabilizes MTs.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Centriole and centriolar satellite protein OFD1;Protein moonraker;Centrosomal protein 20	OFD1;KIAA0753;CEP20	CXorf5;MNR OFIP;C16orf63 FOPNL FOR20 PHSECRG2
6443	SMAR1-HDAC1-SIN3A-SIN3B repressor complex	Human	BANP-HDAC1-SIN3A-SIN3B repressor complex	293 cell lysate	O75182;Q13547;Q8N9N5;Q96ST3	23309;3065;54971;25942	MI:0007-anti tag coimmunoprecipitation	GO:0006355;GO:0005634	regulation of DNA-templated transcription;nucleus	11.02.03.04;70.10	transcriptional control;nucleus	16166625	The authors demonstrate that SMAR1 represses cyclin D1gene expression by acting as a transcriptional repressor.	Amplification and dysregulation of cyclin D1 is predominantly observed in breast carcinomas. In the majority of the breast cancer cell lines used, elevated levels of cyclin D1 were correlated with drastically reduced levels of SMAR1.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Paired amphipathic helix protein Sin3b;Histone deacetylase 1;Protein BANP;Paired amphipathic helix protein Sin3a	SIN3B;HDAC1;BANP;SIN3A	KIAA0700;RPD3L1;BEND1, SMAR1;None
6444	SMAR1-HDAC1-SIN3A-SIN3B-p107-p130 repressor complex	Human	BANP-HDAC1-SIN3A-SIN3B-RBL1-RBL2 repressor complex	293 cell lysate	O75182;P28749;Q08999;Q13547;Q8N9N5;Q96ST3	23309;5933;5934;3065;54971;25942	MI:0007-anti tag coimmunoprecipitation	GO:0006355;GO:0005634	regulation of DNA-templated transcription;nucleus	11.02.03.04;70.10	transcriptional control;nucleus	16166625	The authors demonstrate that SMAR1 represses cyclin D1 gene expression by acting as a transcriptional repressor.	Amplification and dysregulation of cyclin D1 is predominantly observed in breast carcinomas. In the majority of the breast cancer cell lines used, elevated levels of cyclin D1 were correlated with drastically reduced levels of SMAR1.	Although the authors observed the interaction of pocket Rb proteins (RBL1, RBL2) in the SMAR1-associated complex, Western analysis data from an Rb-None cell line (MDA-MB-468) and Rb-inactive cell lines (293 and HBL-100) suggest that the Rb is dispensable for SMAR1-mediated cyclin D1 repression.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Paired amphipathic helix protein Sin3b;Retinoblastoma-like protein 1;Retinoblastoma-like protein 2;Histone deacetylase 1;Protein BANP;Paired amphipathic helix protein Sin3a	SIN3B;RBL1;RBL2;HDAC1;BANP;SIN3A	KIAA0700;None;RB2;RPD3L1;BEND1, SMAR1;None
6445	TIM23(sort) subcomplex (TIMM23, TIMM50), mitochondrial	Human	TIM23-TIM50 complex	HeLa cells; 293T cells	O14925;Q3ZCQ8	100287932;92609	MI:0018-two hybrid;MI:0019-coimmunoprecipitation;MI:0416-fluorescence microscopy	GO:0005744;GO:0005743;GO:0071806;GO:0006839;GO:0006626;GO:0005739	TIM23 mitochondrial import inner membrane translocase complex;mitochondrial inner membrane;protein transmembrane transport;mitochondrial transport;protein targeting to mitochondrion;mitochondrion	70.16.05;20.09.04;70.16	mitochondrial inner membrane;mitochondrial transport;mitochondrion	15044455	Translocation of nuclear-encoded mitochondrial preproteins is mediated by translocases in the outer (TOM) and inner (TIM) membranes.Tim50, a component of the mitochondrial translocator, regulates mitochondrial integrity and cell death.	The loss of TIM50 suppresses proliferation and induces apoptosis in breast cancer (PMID:26289846). Injection of Tim50-specific morpholino antisense oligonucleotides during early zebrafish embryonic development causes neurodegeneration, dysmorphic hearts, and reduced motility as a result of increased cell death (PMID:15044455).	None	Homo sapiens (Human);Homo sapiens (Human)	Mitochondrial import inner membrane translocase subunit Tim23;Mitochondrial import inner membrane translocase subunit TIM50	TIMM23;TIMM50	TIM23;TIM50
6446	Set/TAF-I beta-TAF-I alpha-PP32 complex	Human	None	HeLa nuclear extracts	P39687;Q01105-1;Q01105-2	8125;6418;6418	MI:0019-coimmunoprecipitation;MI:0071-molecular sieving;MI:0226-ion exchange chromatography	GO:0035067;GO:0006338;GO:0048387;GO:0006355	negative regulation of histone acetylation;chromatin remodeling;negative regulation of retinoic acid receptor signaling pathway;regulation of DNA-templated transcription	11.02.03.04	transcriptional control	11163245	Set/TAF-Ib, TAF-Ia, and pp32 are subunits of the INHAT (inhibitor of acetyltransferases) complex. INHAT functions by masking the accessibility of lysines of histones to the acetylases.	None	Except for the subtype-specific N-terminus, splice variants Set/TAF-Ib and TAF-Ia are identical. UniProtKB - Q01105 shows isoform 1 as TAF-I alpha and isoform 2 as TAF-I beta.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Acidic leucine-rich nuclear phosphoprotein 32 family member A;Isoform 1 of Protein SET;Isoform 2 of Protein SET	ANP32A;SET;SET	C15orf1 LANP MAPM PHAP1;None;None
6447	HSD3B2-TIMM23-TIMM50-TOMM22 complex	Human	TIM23-TOM22-TIM50-3betaHSD2 complex	adrenal NCI H295 cells	O14925;P26439;Q3ZCQ8;Q9NS69	100287932;3284;92609;56993	MI:0019-coimmunoprecipitation;MI:0029-cosedimentation through density gradient;MI:0069-mass spectrometry studies of complexes	GO:0050810;GO:0005743	regulation of steroid biosynthetic process;mitochondrial inner membrane	70.16.05	mitochondrial inner membrane	21930695	Inner mitochondrial translocase Tim50 interacts with 3beta-hydroxysteroid dehydrogenase type 2 to regulate adrenal and gonadal steroidogenesis. Through mass spectrometry and Western blotting of mitochondrial complexes and density gradient ultracentrifugation, it was shown that that 3betaHSD2 formed a transient association with the translocases Tim50 and Tom22 and with Tim23. This association occurred primarily through the interaction of Tim50 with the N terminus of 3betaHSD2 and contributed to enzymatic activity.	None	3betaHSD2 catalyzes the conversion of pregnenolone to progesterone and dehydroepiandrostenedione to androstenedione. Alterations in this pathway can have deleterious effects, including sexual development impairment, spontaneous abortion, and breast cancer.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mitochondrial import inner membrane translocase subunit Tim23;3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2;Mitochondrial import inner membrane translocase subunit TIM50;Mitochondrial import receptor subunit TOM22 homolog	TIMM23;HSD3B2;TIMM50;TOMM22	TIM23;HSDB3B;TIM50;TOM22
6450	DJ-1-DJBP-AR complex	Human	None	293T cells, treated with testosterone	P10275;Q5THR3;Q99497	367;64800;11315	MI:0007-anti tag coimmunoprecipitation	GO:0060765;GO:0006355	regulation of androgen receptor signaling pathway;regulation of DNA-templated transcription	11.02.03.04	transcriptional control	12612053	DJBP directly binds to both DJ-1 and AR in a testosterone-dependent manner and  DJ-1 associates with AR via DJBP in a ternary complex. DJBP was found to inhibit AR transcription activity by recruiting histone-deacetylase complexes, including HDAC1 and mSin3, and DJ-1 was found to restore the repressed activity of the AR.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Androgen receptor;EF-hand calcium-binding domain-containing protein 6;Parkinson disease protein 7	AR;EFCAB6;PARK7	DHTR, NR3C4;DJBP KIAA1672;None
6451	MAK-ACTR-AR complex	Human	MAK-NCOA3-AR complex	293T cells	P10275;P20794;Q9Y6Q9	367;4117;8202	MI:0019-coimmunoprecipitation	GO:0060765;GO:0006355	regulation of androgen receptor signaling pathway;regulation of DNA-templated transcription	11.02.03.04	transcriptional control	16951154	MAK and ACTR seem to be in proximity and synergize with each other in the transactivation of AR.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Androgen receptor;Serine/threonine-protein kinase MAK;Nuclear receptor coactivator 3	AR;MAK;NCOA3	DHTR, NR3C4;None;AIB1 BHLHE42 RAC3 TRAM1
6452	TIMM8A-TIMM13 complex, mitochondrial	Human	DDP1-TIM13 complex, mitochondrial; hTim13 complex; TIMM8A-TIMM13 70K mitochondrial intermembrane space complex	HeLa cells	O60220;Q9Y5L4	1678;26517	MI:0019-coimmunoprecipitation;MI:0071-molecular sieving;MI:0413-electrophoretic mobility shift assay	GO:0005758;GO:0071806;GO:0006626	mitochondrial intermembrane space;protein transmembrane transport;protein targeting to mitochondrion	70.16.03	mitochondrial intermembrane space	11489896	The DDP1-Tim13 complex acts in the intermembrane space and specifically assists the import of the Tim23 precursors into the mitochondrial inner membrane thereby forming a hetero-oligomeric complex of 70 kDa. It is suggested that an impaired mitochondrial preprotein import is the pathogenetic basis of the Mohr-Tranebjaerg syndrome. Antibodies against DDP1 and hTim13 did not precipitate hTim9, hTim10a, or hTim10b.	Mutations in the DDP1 cause the Mohr-Tranebjaerg syndrome, a progressive neurodegenerative disorder characterized by sensorineural hearing loss, dystonia, mental retardation, and blindness.	The 70-kDa complex appears to be composed of three molecules of DDP1 and three molecules of hTim13. However, it cannot be decided whether this stoichiometry is fixed or determined by the relative expression levels of the components.	Homo sapiens (Human);Homo sapiens (Human)	Mitochondrial import inner membrane translocase subunit Tim8 A;Mitochondrial import inner membrane translocase subunit Tim13	TIMM8A;TIMM13	DDP DDP1 TIM8A;TIM13B TIMM13A TIMM13B
6455	ARL2-TBCD complex	Human	ARL2-Tubulin-folding cofactor D complex	293T cells	P36404;Q9BTW9	402;6904	MI:0030-cross-linking study	GO:0000226	microtubule cytoskeleton organization	42.04.05	microtubule cytoskeleton	10831612	Arl2 has a role in modulating the interaction of tubulin-folding cofactors with native tubulin in vivo.	None	None	Homo sapiens (Human);Homo sapiens (Human)	ADP-ribosylation factor-like protein 2;Tubulin-specific chaperone D	ARL2;TBCD	None;KIAA0988 SSD1 TFCD
6456	TIM23(sort) subcomplex (TIMM17A, TIMM23), mitochondrial	Human	TIM17A-TIM23 complex	HEK293T cells; HeLa cells; Huh7 cells	O14925;Q99595	100287932;10440	MI:0019-coimmunoprecipitation	GO:0098800;GO:0006950;GO:0071806;GO:0005744;GO:0005743;GO:0015031;GO:0006626;GO:0005739;GO:0006839	inner mitochondrial membrane protein complex;response to stress;protein transmembrane transport;TIM23 mitochondrial import inner membrane translocase complex;mitochondrial inner membrane;protein transport;protein targeting to mitochondrion;mitochondrion;mitochondrial transport	32.01;70.16.05;20.01.10;70.16;20.09.04	stress response;mitochondrial inner membrane;protein transport;mitochondrion;mitochondrial transport	24315374	Tim17A is a stress-regulated subunit of the translocase of the inner membrane 23 (TIM23) mitochondrial protein import complex. It is indicated that Tim17A degradation is a stress-responsive mechanism by which cells adapt mitochondrial protein import efficiency and promote mitochondrial proteostasis in response to the numerous pathologic insults that induce stress-regulated translation attenuation.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Mitochondrial import inner membrane translocase subunit Tim23;Mitochondrial import inner membrane translocase subunit Tim17-A	TIMM23;TIMM17A	TIM23;MIMT17 TIM17 TIM17A TIMM17
6457	MLL1 core complex	Human	None	HEK293 cells	P61964;Q03164;Q15291;Q9UBL3	11091;4297;5929;9070	MI:0007-anti tag coimmunoprecipitation	GO:0051568	histone H3-K4 methylation	None	None	22665483	Whereas wild-type MLL1 co-immunoprecipitates theWDR5, RbBP5, and Ash2L subcomplex, co-immunoprecipitation is abolished when Arg-3765 of MLL1 is replaced with alanine.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	WD repeat-containing protein 5;Histone-lysine N-methyltransferase 2A;Retinoblastoma-binding protein 5;Set1/Ash2 histone methyltransferase complex subunit ASH2	WDR5;KMT2A;RBBP5;ASH2L	BIG3;ALL1 CXXC7 HRX HTRX MLL MLL1 TRX1;RBQ3;ASH2L1
6458	TIM23(sort) subcomplex (TIMM17B, TIMM23), mitochondrial	Human	TIM17B-TIM23 complex, mitochondrial	HEK293T cells; HeLa cells; Huh7 cells	O14925;O60830	100287932;10245	MI:0019-coimmunoprecipitation	GO:0098800;GO:0045039;GO:0006950;GO:0071806;GO:0030150;GO:0005744;GO:0005743;GO:0005739;GO:0006626;GO:0006839	inner mitochondrial membrane protein complex;protein insertion into mitochondrial inner membrane;response to stress;protein transmembrane transport;protein import into mitochondrial matrix;TIM23 mitochondrial import inner membrane translocase complex;mitochondrial inner membrane;mitochondrion;protein targeting to mitochondrion;mitochondrial transport	32.01;70.16.05;70.16;20.09.04	stress response;mitochondrial inner membrane;mitochondrion;mitochondrial transport	24315374	The translocase TIM23 is responsible for importing two-thirds of the mitochondrial proteome across the inner mitochondrial membrane into the mitochondrial matrix. TIM17A and TIM17B are expressed ubiquitously in mammals, however they demonstrate tissue-specific expression profiles with TIM17A enriched in the brain and TIM17B enriched in skeletal muscle. No functional differences between Tim17A and Tim17B are currently known. Tim17A and Tim17B co-immunopurify with Tim23 in mitochondria.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Mitochondrial import inner membrane translocase subunit Tim23;Mitochondrial import inner membrane translocase subunit Tim17-B	TIMM23;TIMM17B	TIM23;TIM17B
6459	EARP complex	Human	Endosome-associated recycling protein complex	HeLa cells	Q5VIR6;Q8N1B4;Q96JG6;Q9UID3	55275;6293;55610;738	MI:0019-coimmunoprecipitation;MI:0071-molecular sieving	GO:0032456	endocytic recycling	None	None	25799061	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Vacuolar protein sorting-associated protein 53 homolog;Vacuolar protein sorting-associated protein 52 homolog;Syndetin;Vacuolar protein sorting-associated protein 51 homolog	VPS53;VPS52;VPS50;VPS51	None;SACM2L;CCDC132,KIAA1861;ANG2 C11orf2 C11orf3 FFR
6460	MLL2 complex	Human	None	HeLa nuclear extracts	O00255;O14686;O15294;O75475;P51610;P61964;Q15291;Q9C005;Q9UBL3;Q9Y5Z7	4221;8085;8473;11168;3054;11091;5929;84661;9070;29915	MI:0069-mass spectrometry studies of complexes;MI:0096-pull down	GO:0051568;GO:0006355;GO:0005634;GO:0006325	histone H3-K4 methylation;regulation of DNA-templated transcription;nucleus;chromatin organization	11.02.03.04;70.10	transcriptional control;nucleus	23508102	None	None	Corresponding to protein Menin, the authors refer to isoform 2 of Uniprot: O00255 (O00255-2).The authors did not specify the proteins HCFC1 and HCFC2. Both proteins are shown alternatively.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Menin;Histone-lysine N-methyltransferase 2D;UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit;PC4 and SFRS1-interacting protein;Host cell factor 1;WD repeat-containing protein 5;Retinoblastoma-binding protein 5;Protein dpy-30 homolog;Set1/Ash2 histone methyltransferase complex subunit ASH2;Host cell factor 2	MEN1;KMT2D;OGT;PSIP1;HCFC1;WDR5;RBBP5;DPY30;ASH2L;HCFC2	SCG2;ALR MLL2 MLL4;None;DFS70 LEDGF PSIP2;HCF1, HFC1;BIG3;RBQ3;None;ASH2L1;None
6461	MLL3 complex	Human	None	HeLa nuclear extracts	O15550;P61964;Q14686;Q15291;Q6ZW49;Q8NEZ4;Q9BTK6;Q9C005;Q9UBL3	7403;11091;23054;5929;22976;58508;79447;84661;9070	MI:0069-mass spectrometry studies of complexes;MI:0096-pull down	GO:0051568;GO:0005634;GO:0006355;GO:0006325	histone H3-K4 methylation;nucleus;regulation of DNA-templated transcription;chromatin organization	70.10;11.02.03.04	nucleus;transcriptional control	23508102	None	None	Corresponding to protein MLL3, the authors refer to isoform 3 of Uniprot: Q8NEZ4 (Q8NEZ4-3).	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Lysine-specific demethylase 6A;WD repeat-containing protein 5;Nuclear receptor coactivator 6;Retinoblastoma-binding protein 5;PAX-interacting protein 1;Histone-lysine N-methyltransferase 2C;PAXIP1-associated glutamate-rich protein 1;Protein dpy-30 homolog;Set1/Ash2 histone methyltransferase complex subunit ASH2	KDM6A;WDR5;NCOA6;RBBP5;PAXIP1;KMT2C;PAGR1;DPY30;ASH2L	UTX;BIG3;AIB3 KIAA0181 RAP250 TRBP;RBQ3;PAXIP1L PTIP;HALR, KIAA1506, MLL3;C16orf53, PA1;None;ASH2L1
6462	MLL1 complex	Human	None	HeLa nuclear extracts	O00255;O15294;P51610;P61964;Q03164;Q15291;Q9C005;Q9UBL3	4221;8473;3054;11091;4297;5929;84661;9070	MI:0069-mass spectrometry studies of complexes;MI:0096-pull down	GO:0051568;GO:0006355;GO:0005634;GO:0006325	histone H3-K4 methylation;regulation of DNA-templated transcription;nucleus;chromatin organization	11.02.03.04;70.10	transcriptional control;nucleus	23508102	None	None	Corresponding to protein Menin, the authors refer to isoform 2 of Uniprot: O00255 (O00255-2). Since the authors did not specify host cell factor, we used HCFC1	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Menin;UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit;Host cell factor 1;WD repeat-containing protein 5;Histone-lysine N-methyltransferase 2A;Retinoblastoma-binding protein 5;Protein dpy-30 homolog;Set1/Ash2 histone methyltransferase complex subunit ASH2	MEN1;OGT;HCFC1;WDR5;KMT2A;RBBP5;DPY30;ASH2L	SCG2;None;HCF1, HFC1;BIG3;ALL1 CXXC7 HRX HTRX MLL MLL1 TRX1;RBQ3;None;ASH2L1
6463	GARP complex	Human	Golgi-associated retrograde protein complex; Vps fifty-three complex; VFT complex	HeLa cells	Q5VIR6;Q8N1B4;Q9P1Q0;Q9UID3	55275;6293;51542;738	MI:0019-coimmunoprecipitation	GO:0042147;GO:0005802;GO:0000938	retrograde transport, endosome to Golgi;trans-Golgi network;GARP complex	None	None	20685960	GARP deficiency results in accumulation of sphingolipid synthesis intermediates and lysosomal dysfunction, indicating that GARP is necessary for sphingolipid homeostasis (PMID:26357016).	People with mutations in VPS53, a subunit of the GARP complex, suffer from a severe neurodegenerative disease known as \u2018progressive cerebello-cerebral atrophy type 2\u2019 (PCCA2).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Vacuolar protein sorting-associated protein 53 homolog;Vacuolar protein sorting-associated protein 52 homolog;Vacuolar protein sorting-associated protein 54;Vacuolar protein sorting-associated protein 51 homolog	VPS53;VPS52;VPS54;VPS51	None;SACM2L;HCC8;ANG2 C11orf2 C11orf3 FFR
6466	NINJ1 homo-oligomer complex	Human	Ninjurin1 homo-oligomer complex	None	Q92982	4814	MI:0055-fluorescent resonance energy transfer	GO:0007155	cell adhesion	34.07	cell adhesion	28067406	None	None	None	Homo sapiens (Human)	Ninjurin-1	NINJ1	None
6467	MLL4 complex	Human	None	HeLa nuclear extracts	O14686;O15550;P61964;Q14686;Q15291;Q6ZW49;Q9BTK6;Q9C005;Q9UBL3	8085;7403;11091;23054;5929;22976;79447;84661;9070	MI:0069-mass spectrometry studies of complexes;MI:0096-pull down	GO:0051568;GO:0005634;GO:0006355;GO:0006325	histone H3-K4 methylation;nucleus;regulation of DNA-templated transcription;chromatin organization	70.10;11.02.03.04	nucleus;transcriptional control	23508102	None	None	Corresponding to protein MLL4, the authors refer to isoform 3 of Uniprot: O14686 (O14686-3).	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone-lysine N-methyltransferase 2D;Lysine-specific demethylase 6A;WD repeat-containing protein 5;Nuclear receptor coactivator 6;Retinoblastoma-binding protein 5;PAX-interacting protein 1;PAXIP1-associated glutamate-rich protein 1;Protein dpy-30 homolog;Set1/Ash2 histone methyltransferase complex subunit ASH2	KMT2D;KDM6A;WDR5;NCOA6;RBBP5;PAXIP1;PAGR1;DPY30;ASH2L	ALR MLL2 MLL4;UTX;BIG3;AIB3 KIAA0181 RAP250 TRBP;RBQ3;PAXIP1L PTIP;C16orf53, PA1;None;ASH2L1
6468	TRAPP complex oligomer	Human	None	HEK293T cells	O43617;O75865;P0DI81;P48553;Q5T215;Q7Z392;Q86SZ2;Q8IUR0;Q8WVT3;Q96Q05;Q9UL33;Q9Y296;Q9Y2L5;Q9Y5R8	27095;79090;6399;7109;100128327;60684;122553;126003;51112;83696;51693;51399;22878;58485	MI:0019-coimmunoprecipitation;MI:0071-molecular sieving;MI:0676-tandem affinity purification	GO:0006888;GO:0016192;GO:0030137;GO:0060271	endoplasmic reticulum to Golgi vesicle-mediated transport;vesicle-mediated transport;COPI-coated vesicle;cilium assembly	20.09.07.03;20.09.07	ER to Golgi transport;vesicular transport (Golgi network, etc.)	21525244	The human TRAPP complex forms oligomers. Oligomerization of TRAPP can give rise to complexes with variable components in any one of several positions (i.e., C6a/b, C3/C3L) and might allow for a combinatorial diversification of TRAPP function, perhaps regulating cell-specific activities.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Trafficking protein particle complex subunit 3;Trafficking protein particle complex subunit 6A;Trafficking protein particle complex subunit 2;Trafficking protein particle complex subunit 10;Trafficking protein particle complex subunit 3-like protein;Trafficking protein particle complex subunit 11;Trafficking protein particle complex subunit 6B;Trafficking protein particle complex subunit 5;Trafficking protein particle complex subunit 12;Trafficking protein particle complex subunit 9;Trafficking protein particle complex subunit 2-like protein;Trafficking protein particle complex subunit 4;Trafficking protein particle complex subunit 8;Trafficking protein particle complex subunit 1	TRAPPC3;TRAPPC6A;TRAPPC2;TRAPPC10;TRAPPC3L;TRAPPC11;TRAPPC6B;TRAPPC5;TRAPPC12;TRAPPC9;TRAPPC2L;TRAPPC4;TRAPPC8;TRAPPC1	BET3;None;SEDL;EHOC1,TMEM1;BET3L;C4orf41;None;None;TRAMM TTC15;KIAA1882 NIBP;None;SBDN;KIAA1012;BET5,MUM2
6469	Set1A complex	Human	None	HeLa nuclear extracts	O15047;O15294;P51610;P61964;Q15291;Q6UXN9;Q9C005;Q9P0U4;Q9UBL3;Q9Y5Z7	9739;8473;3054;11091;5929;80335;84661;30827;9070;29915	MI:0069-mass spectrometry studies of complexes;MI:0096-pull down	GO:0051568;GO:0005634;GO:0006355;GO:0006325	histone H3-K4 methylation;nucleus;regulation of DNA-templated transcription;chromatin organization	70.10;11.02.03.04	nucleus;transcriptional control	23508102	None	None	Corresponding to protein CXXC1 (CFP1) , the authors refer to isoform 2 of Uniprot: Q9P0U4 (Q9P0U4-2).The authors did not specify the proteins HCFC1 and HCFC2. Both proteins are shown alternatively.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone-lysine N-methyltransferase SETD1A;UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit;Host cell factor 1;WD repeat-containing protein 5;Retinoblastoma-binding protein 5;WD repeat-containing protein 82;Protein dpy-30 homolog;CXXC-type zinc finger protein 1;Set1/Ash2 histone methyltransferase complex subunit ASH2;Host cell factor 2	SETD1A;OGT;HCFC1;WDR5;RBBP5;WDR82;DPY30;CXXC1;ASH2L;HCFC2	KIAA0339 KMT2F SET1 SET1A;None;HCF1, HFC1;BIG3;RBQ3;SWD2 TMEM113 WDR82A;None;CFP1 CGBP PCCX1 PHF18;ASH2L1;None
6470	Set1B complex	Human	None	HeLa nuclear extracts	O15294;P51610;P61964;Q15291;Q6UXN9;Q8NFC6;Q96IK1;Q9C005;Q9P0U4;Q9UBL3;Q9UPS6;Q9Y5Z7	8473;3054;11091;5929;80335;259282;91272;84661;30827;9070;23067;29915	MI:0069-mass spectrometry studies of complexes;MI:0096-pull down	GO:0051568;GO:0005634;GO:0006355;GO:0006325	histone H3-K4 methylation;nucleus;regulation of DNA-templated transcription;chromatin organization	70.10;11.02.03.04	nucleus;transcriptional control	23508102	None	None	Corresponding to protein CXXC1 (CFP1) , the authors refer to isoform 2 of Uniprot: Q9P0U4 (Q9P0U4-2).The authors did not specify the proteins HCFC1 and HCFC2. Both proteins are shown alternatively.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit;Host cell factor 1;WD repeat-containing protein 5;Retinoblastoma-binding protein 5;WD repeat-containing protein 82;Biorientation of chromosomes in cell division protein 1-like 1;Biorientation of chromosomes in cell division protein 1;Protein dpy-30 homolog;CXXC-type zinc finger protein 1;Set1/Ash2 histone methyltransferase complex subunit ASH2;Histone-lysine N-methyltransferase SETD1B;Host cell factor 2	OGT;HCFC1;WDR5;RBBP5;WDR82;BOD1L1;BOD1;DPY30;CXXC1;ASH2L;SETD1B;HCFC2	None;HCF1, HFC1;BIG3;RBQ3;SWD2 TMEM113 WDR82A;BOD1L FAM44A KIAA1327;FAM44B;None;CFP1 CGBP PCCX1 PHF18;ASH2L1;KIAA1076 KMT2G SET1B;None
6472	VPS34-VPS15-BECLIN1-UVRAG-BCL2 complex	Human	Bcl-2-Beclin1-UVRAG-PI(3)KC3 complex; PIK3C3-PIK3R4-BECN1-UVRAG-BCL2 complex	HEK293T cells	P10415;Q14457;Q8NEB9;Q99570;Q9P2Y5	596;8678;5289;30849;7405	MI:0096-pull down	GO:0000045	autophagosome assembly	None	None	16799551	Beclin1 functions as a platform to form a Bcl-2\u2013UVRAG\u2013PI(3)KC3 multiprotein complex in which binding of each constituent requires a different region of Beclin1. Bcl-2\u2013Beclin1 interaction declines during starvation, whereas the UVRAG\u2013Beclin1 interaction remains intact. This indicates that UVRAG and Bcl-2 function as activator and repressor, respectively. Under stressed conditions, Bcl-2 only weakly associates with the Beclin\u2013PI(3)KC3 complex, whereas UVRAG remains in the complex, resulting in continuously activating signal transduction and thus unbalanced, amplified autophagy. (PMID:16799551)	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Apoptosis regulator Bcl-2;Beclin-1;Phosphatidylinositol 3-kinase catalytic subunit type 3;Phosphoinositide 3-kinase regulatory subunit 4;UV radiation resistance-associated gene protein	BCL2;BECN1;PIK3C3;PIK3R4;UVRAG	None;GT197;VPS34;VPS15;None
6473	Mitochondrial calcium uniporter complex	Human	Mitochondrial calcium uniplex; MCU complex	HEK-293T cells; HeLa cells	Q8IYU8;Q8NE86;Q9BPX6;Q9H4I9;Q9NWR8	221154;90550;10367;91689;55013	MI:0007-anti tag coimmunoprecipitation;MI:0069-mass spectrometry studies of complexes	GO:0006851;GO:0005739;GO:0051560	mitochondrial calcium ion transmembrane transport;mitochondrion;mitochondrial calcium ion homeostasis	70.16	mitochondrion	24231807	Subunit EMRE (SMDT1) is essential for in vivo uniporter current and additionally bridges the calcium-sensing role of MICU1 and MICU2 with the calcium conducting role of MCU.	Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling (OMIM:615673, PMID:24336167).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Calcium uptake protein 2, mitochondrial;Calcium uniporter protein, mitochondrial;Calcium uptake protein 1, mitochondrial;Essential MCU regulator, mitochondrial;Calcium uniporter regulatory subunit MCUb, mitochondrial	MICU2;MCU;MICU1;SMDT1;MCUB	EFHA1;C10orf42, CCDC109A;CALC, CBARA1;C22orf32 EMRE;CCDC109B
6474	Cubam complex	Human	Cubiln-AMN complex; Cubilin-amnionless complex	renal cortex membranes	O60494;Q9BXJ7	8029;81693	MI:0004-affinity chromatography technology;MI:0071-molecular sieving	GO:0006897;GO:0015889	endocytosis;cobalamin transport	20.09.18.09.01	endocytosis	14576052	None	Imerslund-Gr\u00e4sbeck syndrome (I-GS; megaloblastic anemia 1, OMIM:261100), is caused by genetic defects in either the cubilin or AMN genes. IG-S is characterized by selective malabsorption of cobalamin (vitamin B(12)) despite normal production and function of intrinsic factor GIF.	None	Homo sapiens (Human);Homo sapiens (Human)	Cubilin;Protein amnionless	CUBN;AMN	IFCR;None
6476	erlin1/2-RNF170 complex	Human	None	alpha T3-1 cell line; HeLa cells	O75477;O94905;Q96K19	10613;11160;81790	MI:0019-coimmunoprecipitation	GO:0005789;GO:0001881	endoplasmic reticulum membrane;receptor recycling	None	None	21610068	RNF170 interacts constitutively with the erlin1/2 complex and depletion of the erlin1/2 complex inhibits RNF170 association with activated IP3 receptors but not vice-versa. It appears that RNF170 is recruited to activated IP3 receptors by the erlin1/2 complex.	A  point mutation Arg-to-Cys in human RNF170 is the cause of autosomaldominant sensory ataxia, a rare, progressive ataxia caused bydegeneration of the posterior columns of the spinal cord (OMIM:608984)	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Erlin-1;Erlin-2;E3 ubiquitin-protein ligase RNF170	ERLIN1;ERLIN2;RNF170	C10orf69 KE04 KEO4 SPFH1;C8orf2 SPFH2;None
6477	ZEB2-KDM1A complex	Human	None	T-ALL cell lines	O60315;O60341	9839;23028	MI:0096-pull down	None	None	None	None	28069602	Targeting the ZEB2 protein complex through direct disruption of the ZEB2-KDM1A interaction or pharmacological inhibition of the KDM1A demethylase activity itself could serve as a novel therapeutic strategy for this aggressive subtype of human leukemia and possibly other ZEB2-driven malignancies.	OMIM:613065 Leukemia, acute lymphoblastic; ALL	None	Homo sapiens (Human);Homo sapiens (Human)	Zinc finger E-box-binding homeobox 2;Lysine-specific histone demethylase 1A	ZEB2;KDM1A	KIAA0569 SIP1 ZFHX1B ZFX1B;AOF2 KDM1 KIAA0601 LSD1
6479	Cubilin-intrinsic factor-cobalamin complex	Human	Cubilin-IF-B12 receptor complex	renal cortex membranes	O60494;P27352	8029;2694	MI:0004-affinity chromatography technology	GO:0015889	cobalamin transport	None	None	14576052	Cobalamin (vitamin B12 is bound to the intrinsic factor GIF.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cubilin;Cobalamin binding intrinsic factor	CUBN;CBLIF	IFCR;GIF IFMH
6481	WASH complex	Human	WASH regulatory complex (SHRC)	HeLa cells; Jurkat T cell lysates	A8K0Z3;Q12768;Q2M389;Q9Y3C0;Q9Y4E1	100287171;9897;23325;51019;253725	MI:0004-affinity chromatography technology	GO:0016197;GO:0099050	endosomal transport;vesicle scission	None	None	20498093	None	Strumpellin is mutated in the human disease hereditary spastic paraplegia (OMIM:603563). WASH is a member of the Wiskott-Aldrich syndrome protein family (WASP).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	WASH complex subunit 1;WASH complex subunit 5;WASH complex subunit 4;WASH complex subunit 3;WASH complex subunit 2C	WASHC1;WASHC5;WASHC4;WASHC3;WASHC2C	FAM39E WASH1;KIAA0196;KIAA1033;None;FAM21C KIAA0592 VPEF
6482	CUL4B-DDB1-DTL-CSN complex	Human	None	HeLa cells	P61201;Q13098;Q13620;Q16531;Q9NZJ0	9318;2873;8450;1642;51514	MI:0019-coimmunoprecipitation	None	None	None	None	16861906	CUL4/DDB1 E3 ligase complex plays a critical role in regulating the cell cycle progression, replication and DNA damage.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	COP9 signalosome complex subunit 2;COP9 signalosome complex subunit 1;Cullin-4B;DNA damage-binding protein 1;Denticleless protein homolog	COPS2;GPS1;CUL4B;DDB1;DTL	CSN2, TRIP15;COPS1, CSN1;KIAA0695;XAP1;CDT2 CDW1 DCAF2 L2DTL RAMP
6483	CAPZalpha-CAPZbeta complex	Human	CAPZalpha-CAPZbeta heterodimer complex	HeLa cells	P47756;P52907	832;829	MI:0071-molecular sieving	GO:0051693	actin filament capping	None	None	20498093	CAPZalpha-CAPZbeta complex is weakly associated with the WASH complex.	None	Since the authors did not specify F-actin-capping protein, we used isoform CAPZA1.	Homo sapiens (Human);Homo sapiens (Human)	F-actin-capping protein subunit beta;F-actin-capping protein subunit alpha-1	CAPZB;CAPZA1	None;None
6484	WASH-CAPZalpa/beta complex	Human	None	HeLa cells	A8K0Z3;P47756;P52907;Q12768;Q2M389;Q9Y3C0;Q9Y4E1	100287171;832;829;9897;23325;51019;253725	MI:0071-molecular sieving	GO:0051693;GO:0005769;GO:0034314;GO:0016197;GO:0099050	actin filament capping;early endosome;Arp2/3 complex-mediated actin nucleation;endosomal transport;vesicle scission	None	None	20498093	CAPZalpha/beta heterodimer complex also copurified with WASH complex, but only weakly, suggesting that CAPZ is a peripheral component. FAM21 interacts directly with CAPZ and inhibits its actin-capping activity.	Strumpellin is mutated in the human disease hereditary spastic paraplegia (OMIM:603563). WASH is a member of the Wiskott-Aldrich syndrome protein family (WASP).	Since the authors did not specify F-actin-capping protein, we used isoform CAPZA1.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	WASH complex subunit 1;F-actin-capping protein subunit beta;F-actin-capping protein subunit alpha-1;WASH complex subunit 5;WASH complex subunit 4;WASH complex subunit 3;WASH complex subunit 2C	WASHC1;CAPZB;CAPZA1;WASHC5;WASHC4;WASHC3;WASHC2C	FAM39E WASH1;None;None;KIAA0196;KIAA1033;None;FAM21C KIAA0592 VPEF
6485	HIF1alpha-VHL-ElonginB-ElonginC complex	Human	HIF1alpha-VBC complex; HIF1A-TCEB1-TCEB2-VHL complex	None	P40337;Q15369;Q15370;Q16665	7428;6921;6923;3091	MI:0114-x-ray crystallography	GO:0032364	oxygen homeostasis	None	None	12004076	VHL is responsible for the ubiquitination of  HIF1alpha.	Mutations in the VHL protein are associated with von Hippel\u2013Lindau cancer predisposition syndrome (OMIM:193300).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	von Hippel-Lindau disease tumor suppressor;Elongin-C;Elongin-B;Hypoxia-inducible factor 1-alpha	VHL;ELOC;ELOB;HIF1A	None;TCEB1;TCEB2;BHLHE78 MOP1 PASD8
6486	CUL4A-DDB1-DTL complex	Human	None	HeLa cells	Q13619;Q16531;Q9NZJ0	8451;1642;51514	MI:0019-coimmunoprecipitation	GO:0006974;GO:0030163	cellular response to DNA damage stimulus;protein catabolic process	32.01.09;14.13	DNA damage response;protein/peptide degradation	16861906	CUL4/DDB1 E3 ligase complex plays a critical role in regulating the cell cycle progression, replication and DNA damage.DTL is a protein that associates with CUL4 and DDB1 and is required for CDT1 degradation in response to DNA damage in both Drosophila and human cells.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cullin-4A;DNA damage-binding protein 1;Denticleless protein homolog	CUL4A;DDB1;DTL	None;XAP1;CDT2 CDW1 DCAF2 L2DTL RAMP
6487	CUL4B-DDB1-TLE2 complex	Human	None	HeLa cells	Q04725;Q13620;Q16531	7089;8450;1642	MI:0019-coimmunoprecipitation	GO:0010498	proteasomal protein catabolic process	None	None	17041588	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transducin-like enhancer protein 2;Cullin-4B;DNA damage-binding protein 1	TLE2;CUL4B;DDB1	None;KIAA0695;XAP1
6488	CUL4A-DDB1-EED complex	Human	None	HeLa cells	O75530;Q13619;Q16531	8726;8451;1642	MI:0019-coimmunoprecipitation	GO:0010498;GO:0031060	proteasomal protein catabolic process;regulation of histone methylation	None	None	17041588	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Polycomb protein EED;Cullin-4A;DNA damage-binding protein 1	EED;CUL4A;DDB1	None;None;XAP1
6489	CUL4A-DDB1-WDR5 complex	Human	None	HeLa cells	P61964;Q13619;Q16531	11091;8451;1642	MI:0019-coimmunoprecipitation	GO:0031060;GO:0010498	regulation of histone methylation;proteasomal protein catabolic process	None	None	17041588	WDR5, DDB1 and CUL4A can interact with the H3 N-terminal peptide containing methylated K4, but not its unmodified form in cell lysates, suggesting that these interactions are specific for methylated histone H3.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	WD repeat-containing protein 5;Cullin-4A;DNA damage-binding protein 1	WDR5;CUL4A;DDB1	BIG3;None;XAP1
6490	CUL4B-DDB1-WDR26 complex	Human	None	HEK293 cells	Q13620;Q16531;Q9H7D7	8450;1642;80232	MI:0019-coimmunoprecipitation	None	None	None	None	17041588	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cullin-4B;DNA damage-binding protein 1;WD repeat-containing protein 26	CUL4B;DDB1;WDR26	KIAA0695;XAP1;CDW2 MIP2
6491	CUL4A-DDB1-RBBP5 complex	Human	None	HEK293 cells	Q13619;Q15291;Q16531	8451;5929;1642	MI:0019-coimmunoprecipitation	None	None	None	None	17041588	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cullin-4A;Retinoblastoma-binding protein 5;DNA damage-binding protein 1	CUL4A;RBBP5;DDB1	None;RBQ3;XAP1
6492	CUL4A-DDB1-WDR5B complex	Human	None	HEK293 cells	Q13619;Q16531;Q86VZ2	8451;1642;54554	MI:0019-coimmunoprecipitation	None	None	None	None	17041588	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cullin-4A;DNA damage-binding protein 1;WD repeat-containing protein 5B	CUL4A;DDB1;WDR5B	None;XAP1;None
6493	CUL4A-DDB1-WDR57 complex	Human	CUL4A-DDB1-SNRNP40 complex	HEK293 cells	Q13619;Q16531;Q96DI7	8451;1642;9410	MI:0019-coimmunoprecipitation	None	None	None	None	17041588	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cullin-4A;DNA damage-binding protein 1;U5 small nuclear ribonucleoprotein 40 kDa protein	CUL4A;DDB1;SNRNP40	None;XAP1;PRP8BP SFP38 WDR57
6494	CUL4A-DDB1-WDR61 complex	Human	None	HEK293 cells	Q13619;Q16531;Q9GZS3	8451;1642;80349	MI:0019-coimmunoprecipitation	None	None	None	None	17041588	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cullin-4A;DNA damage-binding protein 1;WD repeat-containing protein 61	CUL4A;DDB1;WDR61	None;XAP1;None
6495	CUL4B-DDB1-GRWD1 complex	Human	None	HEK293 cells	Q13620;Q16531;Q9BQ67	8450;1642;83743	MI:0019-coimmunoprecipitation	None	None	None	None	17041588	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cullin-4B;DNA damage-binding protein 1;Glutamate-rich WD repeat-containing protein 1	CUL4B;DDB1;GRWD1	KIAA0695;XAP1;GRWD KIAA1942 WDR28
6496	TOM subcomplex (TOMM20, TOMM22), mitochondrial	Human	TOM20-TOM22 complex	in vitro	Q15388;Q9NS69	9804;56993	MI:0019-coimmunoprecipitation;MI:0047-far western blotting	GO:0005739;GO:0098799;GO:0005741;GO:0071806;GO:0006839;GO:0006626	mitochondrion;outer mitochondrial membrane protein complex;mitochondrial outer membrane;protein transmembrane transport;mitochondrial transport;protein targeting to mitochondrion	70.16;70.16.01;20.09.04	mitochondrion;mitochondrial outer membrane;mitochondrial transport	10982837	Tom22 functions as an import receptor for preproteins. It forms a receptor complex with human Tom20. The internal segment of the human Tom22 cytosolic domain is important for the complex formation. The N-terminal domain of Tom22 is important for binding to the mature portion of pre-ornithine transcarbamylase (pOTC).	None	human proteins expressed in COS-7 cells	Homo sapiens (Human);Homo sapiens (Human)	Mitochondrial import receptor subunit TOM20 homolog;Mitochondrial import receptor subunit TOM22 homolog	TOMM20;TOMM22	KIAA0016;TOM22
6497	TOM complex (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40, TOMM70), mitochondrial	Human	TOM (TOM5, TOM6, TOM7, TOM20, TOM22, TOM40, TOM70) complex; preprotein translocase complex	HeLa cells	O94826;O96008;Q15388;Q8N4H5;Q96B49;Q9NS69;Q9P0U1	9868;10452;9804;401505;100188893;56993;54543	MI:0019-coimmunoprecipitation;MI:0051-fluorescence technology;MI:0276-blue native page	GO:0005739;GO:0005741;GO:0005742;GO:0070096;GO:0006626;GO:0045041;GO:0006839;GO:0065003	mitochondrion;mitochondrial outer membrane;mitochondrial outer membrane translocase complex;mitochondrial outer membrane translocase complex assembly;protein targeting to mitochondrion;protein import into mitochondrial intermembrane space;mitochondrial transport;protein-containing complex assembly	70.16;70.16.01;20.09.04	mitochondrion;mitochondrial outer membrane;mitochondrial transport	18331822	Most mitochondrial proteins are synthesized in the cytosol as preproteins and transported to the sub-mitochondrial compartments by the preprotein import machineries of the outer and inner mitochondrial membranes (TOM and TIM complex, respectively). hTom5 and hTom6 were newly identified as components of the complex together with hTom70, hTom20, hTom22, hTom40, and hTom7. Knockdown of Tom7, but not Tom5 and Tom6, strongly compromised stability of the TOM complex. Conversely, knockdown of hTom40 decreased the level of all small Tom proteins.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mitochondrial import receptor subunit TOM70;Mitochondrial import receptor subunit TOM40 homolog;Mitochondrial import receptor subunit TOM20 homolog;Mitochondrial import receptor subunit TOM5 homolog;Mitochondrial import receptor subunit TOM6 homolog;Mitochondrial import receptor subunit TOM22 homolog;Mitochondrial import receptor subunit TOM7 homolog	TOMM70;TOMM40;TOMM20;TOMM5;TOMM6;TOMM22;TOMM7	KIAA0719 TOM70 TOMM70A;C19orf1 PEREC1 TOM40;KIAA0016;C9orf105,TOM5;OBTP,TOM6;TOM22;TOM7,TOMM07
6498	TOM subcomplex (TOMM7, TOMM22, TOMM40), mitochondrial	Human	120-kDa complex (TOM7, TOM22, TOM40); preprotein translocase assembly intermediate complex; TOM7 120K intermediate assembly complex (TOMM7, TOMM22, TOMM40), mitochondrial	HeLa cells	O96008;Q9NS69;Q9P0U1	10452;56993;54543	MI:0276-blue native page;MI:0413-electrophoretic mobility shift assay	GO:0005741;GO:0098799;GO:0005739;GO:0071806;GO:0006626;GO:0006839	mitochondrial outer membrane;outer mitochondrial membrane protein complex;mitochondrion;protein transmembrane transport;protein targeting to mitochondrion;mitochondrial transport	70.16.01;70.16;20.09.04	mitochondrial outer membrane;mitochondrion;mitochondrial transport	12198123	Tom7 is a component of the translocase of the outer mitochondrial membrane (TOM) and assembles into a general import pore complex that translocates preproteins into mitochondria. Tom7 does not require ATP for its import and assembly.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mitochondrial import receptor subunit TOM40 homolog;Mitochondrial import receptor subunit TOM22 homolog;Mitochondrial import receptor subunit TOM7 homolog	TOMM40;TOMM22;TOMM7	C19orf1 PEREC1 TOM40;TOM22;TOM7,TOMM07
6499	SOS1-ABI1-EPS8 complex	Human	None	293T cells	Q07889;Q12929;Q8IZP0	6654;2059;10006	MI:0007-anti tag coimmunoprecipitation	GO:0007264;GO:0007169;GO:0031532	small GTPase mediated signal transduction;transmembrane receptor protein tyrosine kinase signaling pathway;actin cytoskeleton reorganization	30.01.05.05.01;30.05.01.12	small GTPase mediated signal transduction;transmembrane receptor protein tyrosine kinase signalling pathways	14565974	Similarly to eps8, eps8Ls interact with Abi1 and Sos-1; however, only eps8L1 and eps8L2 activate the Rac-GEF activity of Sos-1, and bind to actin in vivo.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Son of sevenless homolog 1;Epidermal growth factor receptor kinase substrate 8;Abl interactor 1	SOS1;EPS8;ABI1	None;None;SSH3BP1
6501	SOS1-ABI1-EPS8L1 complex	Human	None	293T cells	Q07889;Q8IZP0;Q8TE68	6654;10006;54869	MI:0007-anti tag coimmunoprecipitation	GO:0031532;GO:0007264;GO:0007169	actin cytoskeleton reorganization;small GTPase mediated signal transduction;transmembrane receptor protein tyrosine kinase signaling pathway	30.01.05.05.01;30.05.01.12	small GTPase mediated signal transduction;transmembrane receptor protein tyrosine kinase signalling pathways	14565974	Similarly to eps8, eps8Ls interact with Abi1 and Sos-1; however, only eps8L1 and eps8L2 activate the Rac-GEF activity of Sos-1, and bind to actin in vivo.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Son of sevenless homolog 1;Abl interactor 1;Epidermal growth factor receptor kinase substrate 8-like protein 1	SOS1;ABI1;EPS8L1	None;SSH3BP1;DRC3 EPS8R1
6502	Estrogen receptor complex (ESR1, EP300, NCOA1)	Human	None	MCF-7 breast cancer cells; HEK-293 cell	P03372;Q09472;Q15788	2099;2033;8648	MI:0019-coimmunoprecipitation;MI:0047-far western blotting;MI:0096-pull down	GO:0043627;GO:0006357	response to estrogen;regulation of transcription by RNA polymerase II	None	None	8876171	ERAP160 directly interacts with ER and associates with p300 in vivo in rabbit reticulocyte lysates. This complex coactivates ER-mediated transcriptional regulation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Estrogen receptor;Histone acetyltransferase p300;Nuclear receptor coactivator 1	ESR1;EP300;NCOA1	ESR NR3A1;P300;BHLHE74 SRC1
6503	SOS1-ABI1-EPS8L2 complex	Human	None	None	Q07889;Q8IZP0;Q9H6S3	6654;10006;64787	MI:0007-anti tag coimmunoprecipitation	GO:0031532;GO:0007264;GO:0007169	actin cytoskeleton reorganization;small GTPase mediated signal transduction;transmembrane receptor protein tyrosine kinase signaling pathway	30.01.05.05.01;30.05.01.12	small GTPase mediated signal transduction;transmembrane receptor protein tyrosine kinase signalling pathways	14565974	Similarly to eps8, eps8Ls interact with Abi1 and Sos-1; however, only eps8L1 and eps8L2 activate the Rac-GEF activity of Sos-1, and bind to actin in vivo.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Son of sevenless homolog 1;Abl interactor 1;Epidermal growth factor receptor kinase substrate 8-like protein 2	SOS1;ABI1;EPS8L2	None;SSH3BP1;EPS8R2
6504	SOS1-ABI1-EPS8L3 complex	Human	None	None	Q07889;Q8IZP0;Q8TE67	6654;10006;79574	MI:0007-anti tag coimmunoprecipitation	None	None	None	None	14565974	The lack of Rac-GEF activity in eps8L3-containing complexes indicated that some additional molecular characteristics, shared by eps8, eps8L1, and eps8L2, are not present in eps8L3. Eps8, eps8L1, and L2, but not eps8L3 could directly associate to F-actin.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Son of sevenless homolog 1;Abl interactor 1;Epidermal growth factor receptor kinase substrate 8-like protein 3	SOS1;ABI1;EPS8L3	None;SSH3BP1;EPS8R3
6505	ERBB3-SPG1 complex	Human	HER3-L1CAM complex	HEK293 cells	P21860;P32004	2065;3897	MI:0019-coimmunoprecipitation	GO:0043125;GO:0038129;GO:1901184;GO:0038131	ErbB-3 class receptor binding;ERBB3 signaling pathway;regulation of ERBB signaling pathway;neuregulin receptor activity	None	None	22815787	During nervous system development different cell-to-cell communication mechanisms operate in parallel guiding migrating neurons and growing axons to generate complex arrays of neural circuits. Cross-regulatory interactions between different signalling pathways and redundancy between them can increase precision and fidelity of guidance systems. Immunoglobulin superfamily proteins of the NCAM and L1 families couple specific substrate recognition and cell adhesion with the activation of receptor tyrosine kinases. It has been shown that L1CAM binds physically erbB receptors. Different Ig-like domains located in the extracellular part of L1CAM can support this interaction. Binding of L1CAM to erbB enhances its response to neuregulins. L1CAM was able to physically interact with erbB3 in HEK293 cells.	Mutations in the human L1-CAM gene are responsible for a complex neurodevelopmental condition, generally referred to as L1 syndrome. Several pathogenic L1-CAM mutations have been identified in humans that cause L1 syndrome in affected individuals without affecting the level of L1-CAM-mediated homophilic cell adhesion when tested in vitro (PMID:19617634).	None	Homo sapiens (Human);Homo sapiens (Human)	Receptor tyrosine-protein kinase erbB-3;Neural cell adhesion molecule L1	ERBB3;L1CAM	HER3;CAML1 MIC5
6506	ERBB2-SPG1 complex	Human	ERBB2-L1CAM complex	HEK293 cells	P04626;P32004	2064;3897	MI:0019-coimmunoprecipitation	GO:0038131;GO:1901184;GO:0038128;GO:0005176	neuregulin receptor activity;regulation of ERBB signaling pathway;ERBB2 signaling pathway;ErbB-2 class receptor binding	None	None	22815787	During nervous system development different cell-to-cell communication mechanisms operate in parallel guiding migrating neurons and growing axons to generate complex arrays of neural circuits. Cross-regulatory interactions between different signalling pathways and redundancy between them can increase precision and fidelity of guidance systems. Immunoglobulin superfamily proteins of the NCAM and L1 families couple specific substrate recognition and cell adhesion with the activation of receptor tyrosine kinases. It has been shown that L1CAM binds physically erbB receptors. Different Ig-like domains located in the extracellular part of L1CAM can support this interaction. Binding of L1CAM to erbB enhances its response to neuregulins. Immunoprecipitation oferbB2 pulled down L1CAM, showing that L1CAM and erbB2receptor are physically bound when expressed in HEK293 cells.	Mutations in the human L1-CAM gene are responsible for a complex neurodevelopmental condition, generally referred to as L1 syndrome. Several pathogenic L1-CAM mutations have been identified in humans that cause L1 syndrome in affected individuals without affecting the level of L1-CAM-mediated homophilic cell adhesion when tested in vitro (PMID:19617634).	None	Homo sapiens (Human);Homo sapiens (Human)	Receptor tyrosine-protein kinase erbB-2;Neural cell adhesion molecule L1	ERBB2;L1CAM	HER2 MLN19 NEU NGL;CAML1 MIC5
6507	SERCA-PLN complex	Human	ATP2A2-PLN complex	HEK293 cells	P16615;P26678	488;5350	MI:0055-fluorescent resonance energy transfer	GO:0006816;GO:1901897;GO:0003697;GO:0035198	calcium ion transport;regulation of relaxation of cardiac muscle;single-stranded DNA binding;miRNA binding	None	None	26292938	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Sarcoplasmic/endoplasmic reticulum calcium ATPase 2;Cardiac phospholamban	ATP2A2;PLN	ATP2B;PLB
6509	pERK-vimentin-KPNA2 complex	Human	None	lung cancer cells	P08670;P27361;P52292	7431;5595;3838	MI:0019-coimmunoprecipitation	GO:0005737;GO:0002347;GO:0016477	cytoplasm;response to tumor cell;cell migration	70.03;34.05.01	cytoplasm;cell migration	25728791	Vimentin binds to phosphorylated ERK1 or ERK2 (PMID:15748847).	pERK-vimentin-KPNA2 complex levels are positively associated with cancer invasiveness. The complex level is higher in advanced stage lung adenocarcinoma compared with that in early-stage cancer tissues.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Vimentin;Mitogen-activated protein kinase 3;Importin subunit alpha-1	VIM;MAPK3;KPNA2	None;ERK1 PRKM3;RCH1, SRP1
6510	ILK-SERCA2A-PLN complex	Human	ILK-ATP22A-PLN complex	iPSC-derived cardiomyocytes	P16615;P26678;Q13418	488;5350;3611	MI:0019-coimmunoprecipitation	GO:1901897;GO:0030018	regulation of relaxation of cardiac muscle;Z disc	None	None	25208486	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Sarcoplasmic/endoplasmic reticulum calcium ATPase 2;Cardiac phospholamban;Integrin-linked protein kinase	ATP2A2;PLN;ILK	ATP2B;PLB;ILK1 ILK2
6512	ILK-HSP90-CDC37 complex	Human	None	HEK293T cells	P07900;Q13418;Q16543	3320;3611;11140	MI:0019-coimmunoprecipitation	None	None	None	None	15882985	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Heat shock protein HSP 90-alpha;Integrin-linked protein kinase;Hsp90 co-chaperone Cdc37	HSP90AA1;ILK;CDC37	HSP90A HSPC1 HSPCA;ILK1 ILK2;CDC37A
6513	MAN1-SMAD2 complex	Human	LEMD3-SMAD2 complex	HEK293T cells	Q15796;Q9Y2U8	4087;23592	MI:0019-coimmunoprecipitation;MI:0114-x-ray crystallography	GO:0007179	transforming growth factor beta receptor signaling pathway	30.05.01.18.01	TGF-beta-receptor signalling pathway	23779087	MAN1 competes with transcription factors for binding to Smad2.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Mothers against decapentaplegic homolog 2;Inner nuclear membrane protein Man1	SMAD2;LEMD3	MADH2 MADR2;MAN1
6514	SLN-ATP2A1 complex	Human	None	None	O00631;O14983	6588;487	MI:0114-x-ray crystallography	GO:0051924	regulation of calcium ion transport	None	None	25983321	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Sarcolipin;Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	SLN;ATP2A1	None;None
6515	SLN-PLN-SERCA1A complex	Human	SLN-PLN-ATP2A1 complex	Skeletal muscle fibers	O00631;O14983;P26678	6588;487;5350	MI:0019-coimmunoprecipitation	GO:1901894	regulation of ATPase-coupled calcium transmembrane transporter activity	None	None	24358354	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Sarcolipin;Sarcoplasmic/endoplasmic reticulum calcium ATPase 1;Cardiac phospholamban	SLN;ATP2A1;PLN	None;None;PLB
6516	SLN-PLN-SERCA2A complex	Human	SLN-PLN-ATP2A2 complex	Skeletal muscle fibers	O00631;P16615;P26678	6588;488;5350	MI:0019-coimmunoprecipitation	GO:1901894	regulation of ATPase-coupled calcium transmembrane transporter activity	None	None	24358354	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Sarcolipin;Sarcoplasmic/endoplasmic reticulum calcium ATPase 2;Cardiac phospholamban	SLN;ATP2A2;PLN	None;ATP2B;PLB
6517	SERCA2a-alphaKAP-CaM-CaMKII complex	Human	ATP2A2-KPNA1-CAMK2A-CALM1 complex	None	P0DP23;P16615;P52294;Q9UQM7	801;488;3836;815	MI:0096-pull down	None	None	None	None	19671701	None	None	P62158 is obsolete. On May 10, 2017 this ID became obsolete. It can now be found as secondary accession in P0DP23, P0DP24 and P0DP25.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Calmodulin-1;Sarcoplasmic/endoplasmic reticulum calcium ATPase 2;Importin subunit alpha-5;Calcium/calmodulin-dependent protein kinase type II subunit alpha	CALM1;ATP2A2;KPNA1;CAMK2A	CALM CAM CAM1;ATP2B;RCH2;CAMKA KIAA0968
6518	CEP164-TTBK2 complex	Human	None	retina	Q6IQ55;Q9UPV0	146057;22897	MI:0018-two hybrid;MI:0096-pull down	GO:0006974;GO:0060271;GO:0005814	cellular response to DNA damage stimulus;cilium assembly;centriole	32.01.09	DNA damage response	22863007	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Tau-tubulin kinase 2;Centrosomal protein of 164 kDa	TTBK2;CEP164	KIAA0847;KIAA1052 NPHP15
6519	CCDC92-CEP164 complex	Human	None	retina	Q53HC0;Q9UPV0	80212;22897	MI:0018-two hybrid;MI:0096-pull down	GO:0006974;GO:0060271	cellular response to DNA damage stimulus;cilium assembly	32.01.09	DNA damage response	22863007	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Coiled-coil domain-containing protein 92;Centrosomal protein of 164 kDa	CCDC92;CEP164	None;KIAA1052 NPHP15
6520	Harmonin-SANS complex	Human	USH1C-USH1G complex	None	Q495M9;Q9Y6N9	124590;10083	MI:0071-molecular sieving;MI:0096-pull down;MI:0114-x-ray crystallography	GO:0043583;GO:0007605	ear development;sensory perception of sound	47.03.02.01;36.25.01.03	ear;hearing	20142502	None	Hearing impairment mutations of harmonin and Sans in Usher syndrome (OMIM:276904) patients are found to disrupt the formation of the harmonin/Sans complex.	None	Homo sapiens (Human);Homo sapiens (Human)	pre-mRNA splicing regulator USH1G;Harmonin	USH1G;USH1C	SANS;AIE75
6521	AKT1-FANCI-FANCD2-PHLPP1-PHLPP2-USP1-WDR48 complex	Human	None	HEK293 cells	O60346;O94782;P31749;Q6ZVD8;Q8TAF3;Q9BXW9;Q9NVI1	23239;7398;207;23035;57599;2177;55215	MI:0019-coimmunoprecipitation	None	None	None	None	27097374	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	PH domain leucine-rich repeat-containing protein phosphatase 1;Ubiquitin carboxyl-terminal hydrolase 1;RAC-alpha serine/threonine-protein kinase;PH domain leucine-rich repeat-containing protein phosphatase 2;WD repeat-containing protein 48;Fanconi anemia group D2 protein;Fanconi anemia group I protein	PHLPP1;USP1;AKT1;PHLPP2;WDR48;FANCD2;FANCI	KIAA0606 PHLPP PLEKHE1 SCOP;None;PKB RAC;KIAA0931, PHLPPL;KIAA1449, UAF1;FACD;KIAA1794
6522	Harmonin-CAD23 complex	Human	USH1C-CDH23 complex; CDH23-harmonin complex	None	Q9H251;Q9Y6N9	64072;10083	MI:0096-pull down	GO:0043583;GO:0007605	ear development;sensory perception of sound	47.03.02.01;36.25.01.03	ear;hearing	19297620	None	Hereditary hearing-vision loss disease Usher syndrome (USH) (OMIM:276904) is caused by defects in USH1C gene.	None	Homo sapiens (Human);Homo sapiens (Human)	Cadherin-23;Harmonin	CDH23;USH1C	KIAA1774 KIAA1812;AIE75
6523	Ubiquilin-VCP-erasin complex	Human	UBQLN1-VCP-UBXN4 complex	HEK293 cells	P55072;Q92575;Q9UMX0	7415;23190;29979	MI:0006-anti bait coimmunoprecipitation;MI:0096-pull down	GO:0036503;GO:0034976	ERAD pathway;response to endoplasmic reticulum stress	None	None	19822669	None	Disturbances in the ER-associated protein degradation (ERAD) pathway are involved in human diseases.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transitional endoplasmic reticulum ATPase;UBX domain-containing protein 4;Ubiquilin-1	VCP;UBXN4;UBQLN1	None;KIAA0242 UBXD2 UBXDC1;DA41 PLIC1
6524	DZIP1-GLI3 complex	Human	None	HEK293 cells	P10071;Q86YF9	2737;22873	MI:0019-coimmunoprecipitation	GO:0060271;GO:0007224	cilium assembly;smoothened signaling pathway	30.05.02.16	hedgehog-dependent signalling pathway	23955340	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Transcriptional activator GLI3;Cilium assembly protein DZIP1	GLI3;DZIP1	None;DZIP DZIP2 KIAA0996
6525	ATL1-ZFYVE27 complex	Human	ZFYVE27-Atlastin1 complex; SPG33-ATL1 complex; SPG3A-SPG33 complex	HEK293T cells	Q5T4F4;Q8WXF7	118813;51062	MI:0019-coimmunoprecipitation	GO:0005783;GO:0016192;GO:0071787;GO:0071788	endoplasmic reticulum;vesicle-mediated transport;endoplasmic reticulum tubular network formation;endoplasmic reticulum tubular network maintenance	70.07;20.09.07	endoplasmic reticulum;vesicular transport (Golgi network, etc.)	24668814	Protrudin is an integral membrane protein that regulates polarized vesicular trafficking in neurons. It possesses a hairpin domain and interacts with HSP-related proteins including myelin proteolipid protein 1 (SPG2), atlastin-1 (SPG3A), REEP1 (SPG31), REEP5 (similar to REEP1), Kif5A (SPG10), Kif5B, Kif5C, and reticulon 1, 3, and 4 (similar to reticulon 2, SPG12). Membrane topology analysis indicated that one of three hydrophobic segments of protrudin forms a hydrophobic hairpin domain similar to those of other SPG proteins. Protrudin was found to localize predominantly to the tubular endoplasmic reticulum (ER), and forced expression of protrudin promoted the formation and stabilization of the tubular ER network. Protrudin facilitates the interaction of Kif5 with Rab11, VAP family proteins, Surf4, and reticulon proteins, suggesting that it serves as an adaptor protein and that the protrudin-Kif5 complex contributes to the transport of these proteins in neurons.	The protrudin gene (ZFYVE27) is mutated in a subset of individuals with hereditary spastic paraplegia (HSP), and protrudin is therefore also referred to as spastic paraplegia 33 (SPG33). It is suggested that protrudin contributes to the regulation of ER morphology and function, and that its deregulation by mutation is a causative defect in HSP.	None	Homo sapiens (Human);Homo sapiens (Human)	Protrudin;Atlastin-1	ZFYVE27;ATL1	SPG33;GBP3, SPG3A
6526	KIF5A-ZFYVE27 complex	Human	Protrudin-NKHC1 complex; SPG10-SPG33 complex	HEK293T cells; HeLa cells	Q12840;Q5T4F4	3798;118813	MI:0019-coimmunoprecipitation;MI:0047-far western blotting	GO:0016192;GO:0071787;GO:0071788;GO:0005783	vesicle-mediated transport;endoplasmic reticulum tubular network formation;endoplasmic reticulum tubular network maintenance;endoplasmic reticulum	20.09.07;70.07	vesicular transport (Golgi network, etc.);endoplasmic reticulum	21976701	Protrudin is a membrane protein that regulates polarized vesicular trafficking in neurons (PMID:24668814). It serves as an adaptor molecule that connects KIF5 and its cargoes in vesicular transport during process formation. Protrudin facilitated the interaction of KIF5 with Rab11, VAP-A and -B, Surf4, and RTN3, suggesting that protrudin serves as an adaptor protein and that the protrudin-KIF5 complex contributes to the transport of these proteins in neurons.	The protrudin gene (ZFYVE27) is mutated in a subset of individuals with hereditary spastic paraplegia (HSP), and protrudin is therefore also referred to as spastic paraplegia 33 (SPG33). It is suggested that protrudin contributes to the regulation of ER morphology and function, and that its deregulation by mutation is a causative defect in HSP (PMID:24668814).	Gene name synonyms are KIF5A/SPG10.	Homo sapiens (Human);Homo sapiens (Human)	Kinesin heavy chain isoform 5A;Protrudin	KIF5A;ZFYVE27	NKHC1;SPG33
6527	FLRT3-LPHN3-UNC5B complex	Human	FLRT3-ADGRL3-UNC5B complex	HEK293 cells	Q8IZJ1;Q9HAR2;Q9NZU0	219699;23284;23767	MI:0054-fluorescence-activated cell sorting	GO:0098609;GO:0007416;GO:0001764	cell-cell adhesion;synapse assembly;neuron migration	41.05.13.01	synaptogenesis	26235030	FLRT3 binds the other two proteins simultaneously and bridges them, although LPHN3 and UNC5 do not directly interact with each other.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Netrin receptor UNC5B;Adhesion G protein-coupled receptor L3;Leucine-rich repeat transmembrane protein FLRT3	UNC5B;ADGRL3;FLRT3	P53RDL1 UNC5H2;KIAA0768 LEC3 LPHN3;KIAA1469
6528	FLRT3-LPHN3-UNC5D complex	Human	FLRT3-ADGRL3-UNC5D complex	HEK293 cells	Q6UXZ4;Q9HAR2;Q9NZU0	137970;23284;23767	MI:0054-fluorescence-activated cell sorting	GO:0098609;GO:0001764;GO:0007416	cell-cell adhesion;neuron migration;synapse assembly	41.05.13.01	synaptogenesis	26235030	FLRT3 binds the other two proteins simultaneously and bridges them, although LPHN3 and UNC5 do not directly interact with each other.	None	The authors mention mouse Unc5D, but describe the Uniprot entry: Q6UXZ4 (human). So the human protein was used.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Netrin receptor UNC5D;Adhesion G protein-coupled receptor L3;Leucine-rich repeat transmembrane protein FLRT3	UNC5D;ADGRL3;FLRT3	KIAA1777,UNC5H4;KIAA0768 LEC3 LPHN3;KIAA1469
6529	FLRT3-LPHN3 complex	Human	FLRT3-ADGRL3 complex	HEK293 cells	Q9HAR2;Q9NZU0	23284;23767	MI:0114-x-ray crystallography	GO:0007416;GO:0098609	synapse assembly;cell-cell adhesion	41.05.13.01	synaptogenesis	26235030	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Adhesion G protein-coupled receptor L3;Leucine-rich repeat transmembrane protein FLRT3	ADGRL3;FLRT3	KIAA0768 LEC3 LPHN3;KIAA1469
6530	MYO7A-PDZD7 complex	Human	None	HEK293 cells	Q13402;Q9H5P4	4647;79955	MI:0006-anti bait coimmunoprecipitation;MI:0096-pull down	GO:0007605;GO:0060171	sensory perception of sound;stereocilium membrane	36.25.01.03	hearing	27525485	None	Mutations in MYO7A affect the development and function of the mechanically sensitive stereocilia of hair cells and are therefore associated with deafness.	None	Homo sapiens (Human);Homo sapiens (Human)	Unconventional myosin-VIIa;PDZ domain-containing protein 7	MYO7A;PDZD7	USH1B;PDZK7
6531	CEP164-DZIP1 complex	Human	None	HEK293 cells	Q86YF9;Q9UPV0	22873;22897	MI:0019-coimmunoprecipitation	GO:0042073;GO:0007224;GO:0060271	intraciliary transport;smoothened signaling pathway;cilium assembly	30.05.02.16	hedgehog-dependent signalling pathway	23955340	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cilium assembly protein DZIP1;Centrosomal protein of 164 kDa	DZIP1;CEP164	DZIP DZIP2 KIAA0996;KIAA1052 NPHP15
6532	TSC2-HERC1 complex	Human	None	HEK283 cells	P49815;Q15751	7249;8925	MI:0006-anti bait coimmunoprecipitation	GO:0031929	TOR signaling	None	None	16464865	TSC1 inhibits the interaction of TSC2 and HERC1 ubiquitin ligase by binding to TSC2. TSC2 pull-down experiments were also performed in mouse brain tissue.	Mutations in TSC2 are associated with tuberous sclerosis (OMIM:613254).In healthy subjects, interaction of TSC1 with TSC2 excludes TSC2 from interacting with HERC1. Disease mutations in TSC2 allow binding to HERC1 also in the presence of TSC1.	None	Homo sapiens (Human);Homo sapiens (Human)	Tuberin;Probable E3 ubiquitin-protein ligase HERC1	TSC2;HERC1	TSC4;None
6533	DZIP1-IFT88 complex	Human	None	HEK293 cells	Q13099;Q86YF9	8100;22873	MI:0019-coimmunoprecipitation	GO:0035720;GO:0060271;GO:0005814;GO:0042073	intraciliary anterograde transport;cilium assembly;centriole;intraciliary transport	None	None	22863007	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Intraflagellar transport protein 88 homolog;Cilium assembly protein DZIP1	IFT88;DZIP1	TG737 TTC10;DZIP DZIP2 KIAA0996
6534	REEP1-ZFYVE27 complex	Human	Protrudin-REEP1 complex; SPG31-SPG33 complex	HEK293T cells	Q5T4F4;Q9H902	118813;65055	MI:0019-coimmunoprecipitation	GO:0005783;GO:0016192;GO:0071787;GO:0071788	endoplasmic reticulum;vesicle-mediated transport;endoplasmic reticulum tubular network formation;endoplasmic reticulum tubular network maintenance	70.07;20.09.07	endoplasmic reticulum;vesicular transport (Golgi network, etc.)	24668814	Protrudin is an integral membrane protein that regulates polarized vesicular trafficking in neurons. It possesses a hairpin domain and interacts with HSP-related proteins including myelin proteolipid protein 1 (SPG2), atlastin-1 (SPG3A), REEP1 (SPG31), REEP5 (similar to REEP1), Kif5A (SPG10), Kif5B, Kif5C, andreticulon 1, 3, and 4 (similar to reticulon 2, SPG12). Membrane topology analysis indicated that one of three hydrophobic segments of protrudin forms a hydrophobic hairpin domain similar to those of other SPG proteins. Protrudin was found to localize predominantly to the tubular endoplasmic reticulum (ER), and forced expression of protrudin promoted the formation and stabilization of the tubular ER network. Protrudin facilitates the interaction of Kif5 with Rab11, VAP family proteins, Surf4, and reticulon proteins, suggesting that it serves as an adaptor protein and that the protrudin-Kif5 complex contributes to the transport of these proteins in neurons.	The protrudin gene (ZFYVE27) is mutated in a subset of individuals with hereditary spastic paraplegia (HSP), and protrudin is therefore also referred to as spastic paraplegia 33 (SPG33). It is suggested that protrudin contributes to the regulation of ER morphology and function, and that its deregulation by mutation is a causative defect in HSP.	None	Homo sapiens (Human);Homo sapiens (Human)	Protrudin;Receptor expression-enhancing protein 1	ZFYVE27;REEP1	SPG33;C2orf23 SPG31
6536	REEP5-ZFYVE27 complex	Human	Protrudin-REEP5 complex; REEP5-SPG33 complex	HEK293T cells	Q00765;Q5T4F4	7905;118813	MI:0019-coimmunoprecipitation	GO:0005783;GO:0016192;GO:0071788;GO:0071787	endoplasmic reticulum;vesicle-mediated transport;endoplasmic reticulum tubular network maintenance;endoplasmic reticulum tubular network formation	70.07;20.09.07	endoplasmic reticulum;vesicular transport (Golgi network, etc.)	24668814	Protrudin is an integral membrane protein that regulates polarized vesicular trafficking in neurons. It possesses a hairpin domain and interacts with HSP-related proteins including myelin proteolipid protein 1 (SPG2), atlastin-1 (SPG3A), REEP1 (SPG31), REEP5 (similar to REEP1), Kif5A (SPG10), Kif5B, Kif5C, andreticulon 1, 3, and 4 (similar to reticulon 2, SPG12). Membrane topology analysis indicated that one of three hydrophobic segments of protrudin forms a hydrophobic hairpin domain similar to those of other SPG proteins. Protrudin was found to localize predominantly to the tubular endoplasmic reticulum (ER), and forced expression of protrudin promoted the formation and stabilization of the tubular ER network. Protrudin facilitates the interaction of Kif5 with Rab11, VAP family proteins, Surf4, and reticulon proteins, suggesting that it serves as an adaptor protein and that the protrudin-Kif5 complex contributes to the transport of these proteins in neurons.	The protrudin gene (ZFYVE27) is mutated in a subset of individuals with hereditary spastic paraplegia (HSP), and protrudin is therefore also referred to as spastic paraplegia 33 (SPG33). It is suggested that protrudin contributes to the regulation of ER morphology and function, and that its deregulation by mutation is a causative defect in HSP.	None	Homo sapiens (Human);Homo sapiens (Human)	Receptor expression-enhancing protein 5;Protrudin	REEP5;ZFYVE27	C5orf18 DP1 TB2;SPG33
6538	VAPA -ZFYVE27 complex	Human	Protrudin-VAP33 comple; SPG33-VAPA complex	HEK293T cells	Q5T4F4;Q9P0L0	118813;9218	MI:0019-coimmunoprecipitation	GO:0005783;GO:0016192;GO:0071787;GO:0071788	endoplasmic reticulum;vesicle-mediated transport;endoplasmic reticulum tubular network formation;endoplasmic reticulum tubular network maintenance	70.07;20.09.07	endoplasmic reticulum;vesicular transport (Golgi network, etc.)	24668814	Protrudin is an integral membrane protein that regulates polarized vesicular trafficking in neurons. It possesses a hairpin domain and interacts with HSP-related proteins including myelin proteolipid protein 1 (SPG2), atlastin-1 (SPG3A), REEP1 (SPG31), REEP5 (similar to REEP1), Kif5A (SPG10), Kif5B, Kif5C, andreticulon 1, 3, and 4 (similar to reticulon 2, SPG12). Membrane topology analysis indicated that one of three hydrophobic segments of protrudin forms a hydrophobic hairpin domain similar to those of other SPG proteins. Protrudin was found to localize predominantly to the tubular endoplasmic reticulum (ER), and forced expression of protrudin promoted the formation and stabilization of the tubular ER network. Protrudin facilitates the interaction of Kif5 with Rab11, VAP family proteins, Surf4, and reticulon proteins, suggesting that it serves as an adaptor protein and that the protrudin-Kif5 complex contributes to the transport of these proteins in neurons.	The protrudin gene (ZFYVE27) is mutated in a subset of individuals with hereditary spastic paraplegia (HSP), and protrudin is therefore also referred to as spastic paraplegia 33 (SPG33). It is suggested that protrudin contributes to the regulation of ER morphology and function, and that its deregulation by mutation is a causative defect in HSP.	None	Homo sapiens (Human);Homo sapiens (Human)	Protrudin;Vesicle-associated membrane protein-associated protein A	ZFYVE27;VAPA	SPG33;VAP33
6540	GPX1-SBP1 complex	Human	None	HCT116 cells	P07203;Q13228	2876;8991	MI:0019-coimmunoprecipitation	GO:0045454	cell redox homeostasis	None	None	20530237	None	The level of SBP1 is reduced in several cancer types. GPX1 is associated with cancer risk and development.	None	Homo sapiens (Human);Homo sapiens (Human)	Glutathione peroxidase 1;Methanethiol oxidase	GPX1;SELENBP1	None;SBP
6545	DCDC2-MAPK8IP1 complex	Human	DCDC2-JIP1 complex	HEK293T cells	Q9UHG0;Q9UQF2	51473;9479	MI:0019-coimmunoprecipitation	GO:0007254;GO:0060271	JNK cascade;cilium assembly	30.01.05.01.02	JNK cascade	25557784	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Doublecortin domain-containing protein 2;C-Jun-amino-terminal kinase-interacting protein 1	DCDC2;MAPK8IP1	KIAA1154 RU2;IB1 JIP1 PRKM8IP
6550	CUL4B-DDB1-TLE1 complex	Human	None	HEK293 cells	Q04724;Q13619;Q16531	7088;8451;1642	MI:0019-coimmunoprecipitation	GO:0010498	proteasomal protein catabolic process	None	None	17041588	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transducin-like enhancer protein 1;Cullin-4A;DNA damage-binding protein 1	TLE1;CUL4A;DDB1	None;None;XAP1
6552	KIF5B -ZFYVE27 complex	Human	KIF5B-SPG33 complex; Protrudin-KNS1 complex	HEK293T cells; HeLa cells	P33176;Q5T4F4	3799;118813	MI:0019-coimmunoprecipitation	GO:0005783;GO:0071787;GO:0071788;GO:0016192	endoplasmic reticulum;endoplasmic reticulum tubular network formation;endoplasmic reticulum tubular network maintenance;vesicle-mediated transport	70.07;20.09.07	endoplasmic reticulum;vesicular transport (Golgi network, etc.)	21976701	Protrudin is a membrane protein that regulates polarized vesicular trafficking in neurons (PMID:24668814). It serves as an adaptor molecule that connects KIF5 and its cargoes in vesicular transport during process formation. Protrudin facilitated the interaction of KIF5 with Rab11, VAP-A and -B, Surf4, and RTN3, suggesting that protrudin serves as an adaptor protein and that the protrudin-KIF5 complex contributes to the transport of these proteins in neurons.	The protrudin gene (ZFYVE27) is mutated in a subset of individuals with hereditary spastic paraplegia (HSP), and protrudin is therefore also referred to as spastic paraplegia 33 (SPG33). It is suggested that protrudin contributes to the regulation of ER morphology and function, and that its deregulation by mutation is a causative defect in HSP (PMID:24668814).	None	Homo sapiens (Human);Homo sapiens (Human)	Kinesin-1 heavy chain;Protrudin	KIF5B;ZFYVE27	KNS, KNS1;SPG33
6553	CUL4B-DDB1-TLE3 complex	Human	None	HEK293 cells	Q04726;Q13620;Q16531	7090;8450;1642	MI:0019-coimmunoprecipitation	GO:0010498	proteasomal protein catabolic process	None	None	17041588	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transducin-like enhancer protein 3;Cullin-4B;DNA damage-binding protein 1	TLE3;CUL4B;DDB1	KIAA1547;KIAA0695;XAP1
6554	KIF5C-ZFYVE27 complex	Human	KIF5C-SPG33 complex; Protrudin-NKHC2 complex	HEK293T cells; HeLa cells	O60282;Q5T4F4	3800;118813	MI:0019-coimmunoprecipitation	GO:0005783;GO:0071787;GO:0071788;GO:0016192	endoplasmic reticulum;endoplasmic reticulum tubular network formation;endoplasmic reticulum tubular network maintenance;vesicle-mediated transport	70.07;20.09.07	endoplasmic reticulum;vesicular transport (Golgi network, etc.)	21976701	Protrudin is a membrane protein that regulates polarized vesicular trafficking in neurons (PMID:24668814). It serves as an adaptor molecule that connects KIF5 and its cargoes in vesicular transport during process formation. Protrudin facilitated the interaction of KIF5 with Rab11, VAP-A and -B, Surf4, and RTN3, suggesting that protrudin serves as an adaptor protein and that the protrudin-KIF5 complex contributes to the transport of these proteins in neurons.	The protrudin gene (ZFYVE27) is mutated in a subset of individuals with hereditary spastic paraplegia (HSP), and protrudin is therefore also referred to as spastic paraplegia 33 (SPG33). It is suggested that protrudin contributes to the regulation of ER morphology and function, and that its deregulation by mutation is a causative defect in HSP (PMID:24668814).	None	Homo sapiens (Human);Homo sapiens (Human)	Kinesin heavy chain isoform 5C;Protrudin	KIF5C;ZFYVE27	KIAA0531,NKHC2;SPG33
6559	KIF5A-RAB11B-ZFYVE27 complex	Human	RAB11B-SPG10-SPG33 complex; ZFYVE27-KIF5A-RAB11B complex; Protrudin-NKHC1-YPT3 complex	HeLa cells	Q12840;Q15907;Q5T4F4	3798;9230;118813	MI:0051-fluorescence technology;MI:0428-imaging technique	GO:0005783;GO:0071787;GO:0071788;GO:0016192	endoplasmic reticulum;endoplasmic reticulum tubular network formation;endoplasmic reticulum tubular network maintenance;vesicle-mediated transport	70.07;20.09.07	endoplasmic reticulum;vesicular transport (Golgi network, etc.)	21976701	Protrudin is a membrane protein that regulates polarized vesicular trafficking in neurons (PMID:24668814). It serves as an adaptor molecule that connects KIF5 and its cargoes in vesicular transport during process formation. Protrudin facilitated the interaction of KIF5 with Rab11, VAP-A and -B, Surf4, and RTN3, suggesting that protrudin serves as an adaptor protein and that the protrudin-KIF5 complex contributes to the transport of these proteins in neurons. Protrudin, KIF5, and Rab11b form a membrane-associated complex, consistent with the fact that protrudin has two putative transmembrane domains.	The protrudin gene (ZFYVE27) is mutated in a subset of individuals with hereditary spastic paraplegia (HSP), and protrudin is therefore also referred to as spastic paraplegia 33 (SPG33). It is suggested that protrudin contributes to the regulation of ER morphology and function, and that its deregulation by mutation is a causative defect in HSP (PMID:24668814).Mutations of protrudin or KIF5 are a cause of human hereditary spastic paraplegia (HSP).	Gene name synonyms are KIF5A/SPG10.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Kinesin heavy chain isoform 5A;Ras-related protein Rab-11B;Protrudin	KIF5A;RAB11B;ZFYVE27	NKHC1;YPT3;SPG33
6561	RAB11A -ZFYVE27 complex	Human	RAB11A-SPG33 complex; Protrudin-RAB11 complex	HeLa cells	P62491;Q5T4F4	8766;118813	MI:0019-coimmunoprecipitation	GO:0005783;GO:0016192	endoplasmic reticulum;vesicle-mediated transport	70.07;20.09.07	endoplasmic reticulum;vesicular transport (Golgi network, etc.)	21976701	Protrudin is a membrane protein that regulates polarized vesicular trafficking in neurons (PMID:24668814). It serves as an adaptor molecule that connects KIF5 and its cargoes in vesicular transport during process formation. Protrudin facilitated the interaction of KIF5 with Rab11, VAP-A and -B, Surf4, and RTN3, suggesting that protrudin serves as an adaptor protein and that the protrudin-KIF5 complex contributes to the transport of these proteins in neurons. Coimmunoprecipitation experiments in HeLa revealed that protrudin also associated with GDP-Rab11a and GDP-Rab11b to similar extents.	The protrudin gene (ZFYVE27) is mutated in a subset of individuals with hereditary spastic paraplegia (HSP), and protrudin is therefore also referred to as spastic paraplegia 33 (SPG33). It is suggested that protrudin contributes to the regulation of ER morphology and function, and that its deregulation by mutation is a causative defect in HSP (PMID:24668814).	None	Homo sapiens (Human);Homo sapiens (Human)	Ras-related protein Rab-11A;Protrudin	RAB11A;ZFYVE27	RAB11;SPG33
6562	RAB11B-ZFYVE27 complex	Human	Protrudin-YPT3 complex; RAB11B-SPG33 complex	HeLa cells	Q15907;Q5T4F4	9230;118813	MI:0019-coimmunoprecipitation	GO:0005783;GO:0016192	endoplasmic reticulum;vesicle-mediated transport	70.07;20.09.07	endoplasmic reticulum;vesicular transport (Golgi network, etc.)	21976701	Protrudin is a membrane protein that regulates polarized vesicular trafficking in neurons (PMID:24668814). It serves as an adaptor molecule that connects KIF5 and its cargoes in vesicular transport during process formation. Protrudin facilitated the interaction of KIF5 with Rab11, VAP-A and -B, Surf4, and RTN3, suggesting that protrudin serves as an adaptor protein and that the protrudin-KIF5 complex contributes to the transport of these proteins in neurons. Coimmunoprecipitation experiments in HeLa revealed that protrudin also associated with GDP-Rab11a and GDP-Rab11b to similar extents.	The protrudin gene (ZFYVE27) is mutated in a subset of individuals with hereditary spastic paraplegia (HSP), and protrudin is therefore also referred to as spastic paraplegia 33 (SPG33). It is suggested that protrudin contributes to the regulation of ER morphology and function, and that its deregulation by mutation is a causative defect in HSP (PMID:24668814).	None	Homo sapiens (Human);Homo sapiens (Human)	Ras-related protein Rab-11B;Protrudin	RAB11B;ZFYVE27	YPT3;SPG33
6563	SURF4-ZFYVE27 complex	Human	SPG33-SURF4 complex; Protrudin-SURF4 complex	HeLa cells	O15260;Q5T4F4	6836;118813	MI:0019-coimmunoprecipitation	GO:0005783;GO:0016192	endoplasmic reticulum;vesicle-mediated transport	70.07;20.09.07	endoplasmic reticulum;vesicular transport (Golgi network, etc.)	21976701	Protrudin is a membrane protein that regulates polarized vesicular trafficking in neurons (PMID:24668814). It serves as an adaptor molecule that connects KIF5 and its cargoes in vesicular transport during process formation. Protrudin facilitated the interaction of KIF5 with Rab11, VAP-A and -B, Surf4, and RTN3, suggesting that protrudin serves as an adaptor protein and that the protrudin-KIF5 complex contributes to the transport of these proteins in neurons. The binding of Surf4 and protrudin was also confirmed in a coimmunoprecipitation assay.	The protrudin gene (ZFYVE27) is mutated in a subset of individuals with hereditary spastic paraplegia (HSP), and protrudin is therefore also referred to as spastic paraplegia 33 (SPG33). It is suggested that protrudin contributes to the regulation of ER morphology and function, and that its deregulation by mutation is a causative defect in HSP (PMID:24668814).	None	Homo sapiens (Human);Homo sapiens (Human)	Surfeit locus protein 4;Protrudin	SURF4;ZFYVE27	SURF-4;SPG33
6565	RTN3-ZFYVE27 complex	Human	Protrudin-NSPL2 complex; RTN3-SPG33 complex	HeLa cells	O95197;Q5T4F4	10313;118813	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0005783;GO:0016192	endoplasmic reticulum;vesicle-mediated transport	70.07;20.09.07	endoplasmic reticulum;vesicular transport (Golgi network, etc.)	21976701	Protrudin is a membrane protein that regulates polarized vesicular trafficking in neurons (PMID:24668814). It serves as an adaptor molecule that connects KIF5 and its cargoes in vesicular transport during process formation. Protrudin facilitated the interaction of KIF5 with Rab11, VAP-A and -B, Surf4, and RTN3, suggesting that protrudin serves as an adaptor protein and that the protrudin-KIF5 complex contributes to the transport of these proteins in neurons. Coimmunoprecipitation experiments also revealed that protrudin interacted directly with RTN3 and promoted the binding of the latter to KIF5A.	The protrudin gene (ZFYVE27) is mutated in a subset of individuals with hereditary spastic paraplegia (HSP), and protrudin is therefore also referred to as spastic paraplegia 33 (SPG33). It is suggested that protrudin contributes to the regulation of ER morphology and function, and that its deregulation by mutation is a causative defect in HSP (PMID:24668814).	None	Homo sapiens (Human);Homo sapiens (Human)	Reticulon-3;Protrudin	RTN3;ZFYVE27	ASYIP, NSPL2;SPG33
6566	VAPB-ZFYVE27 complex	Human	Protrudin-VAPB complex; SPG33-VAPB complex	HeLa cells	O95292;Q5T4F4	9217;118813	MI:0096-pull down	GO:0005783;GO:0016192	endoplasmic reticulum;vesicle-mediated transport	70.07;20.09.07	endoplasmic reticulum;vesicular transport (Golgi network, etc.)	21976701	Protrudin is a membrane protein that regulates polarized vesicular trafficking in neurons (PMID:24668814). It serves as an adaptor molecule that connects KIF5 and its cargoes in vesicular transport during process formation. Protrudin facilitated the interaction of KIF5 with Rab11, VAP-A and -B, Surf4, and RTN3, suggesting that protrudin serves as an adaptor protein and that the protrudin-KIF5 complex contributes to the transport of these proteins in neurons. A pulldown assay revealed also the direct interaction of protrudin with VAP-B.	The protrudin gene (ZFYVE27) is mutated in a subset of individuals with hereditary spastic paraplegia (HSP), and protrudin is therefore also referred to as spastic paraplegia 33 (SPG33). It is suggested that protrudin contributes to the regulation of ER morphology and function, and that its deregulation by mutation is a causative defect in HSP (PMID:24668814).	None	Homo sapiens (Human);Homo sapiens (Human)	Vesicle-associated membrane protein-associated protein B/C;Protrudin	VAPB;ZFYVE27	None;SPG33
6567	SWELL1-containing complex	Human	LRRC8A-containing complex	HeLa cells	Q6NSJ5;Q6P9F7;Q7L1W4;Q8IWT6;Q8TDW0	80131;23507;55144;56262;84230	MI:0004-affinity chromatography technology;MI:0019-coimmunoprecipitation	GO:0005225;GO:0006884	volume-sensitive anion channel activity;cell volume homeostasis	None	None	26824658	For full channel activity LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E) is necessary. LRRC8C-E subunits associated with SWELL1 (LRRC8A) contribute to ion selectivity.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Volume-regulated anion channel subunit LRRC8E;Volume-regulated anion channel subunit LRRC8B;Volume-regulated anion channel subunit LRRC8D;Volume-regulated anion channel subunit LRRC8A;Volume-regulated anion channel subunit LRRC8C	LRRC8E;LRRC8B;LRRC8D;LRRC8A;LRRC8C	None;KIAA0231;LRRC5;KIAA1437 LRRC8 SWELL1;AD158 FAD158
6568	3M core complex	Human	CUL7-CCDC8-OBSL1 complex	293T cells	O75147;Q14999;Q9H0W5	23363;9820;83987	MI:0007-anti tag coimmunoprecipitation	GO:0000226;GO:0005813;GO:0005737	microtubule cytoskeleton organization;centrosome;cytoplasm	42.04.05;70.05;70.03	microtubule cytoskeleton;centrosome;cytoplasm	24793695	None	Besides CUL7, two additional genes, OBSL1 and CCDC8, have been foundto be mutated in 3M syndrome. These three genes are mutated in a mutually exclusive manner, with CUL7 being the most frequently mutated (~65%), followed by OBSL1 (~30%) and CCDC8 (~5%).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Obscurin-like protein 1;Cullin-7;Coiled-coil domain-containing protein 8	OBSL1;CUL7;CCDC8	KIAA0657;KIAA0076;None
6569	SPAST-ZFYVE27 complex	Human	ZFYVE27-Spastin complex; Protrudin-SPAST complex; SPG4-SPG33 complex	HeLa cells	Q5T4F4;Q9UBP0	118813;6683	MI:0018-two hybrid;MI:0019-coimmunoprecipitation;MI:0051-fluorescence technology	GO:0005783;GO:0071787;GO:0016192	endoplasmic reticulum;endoplasmic reticulum tubular network formation;vesicle-mediated transport	70.07;20.09.07	endoplasmic reticulum;vesicular transport (Golgi network, etc.)	16826525	ZFYVE27, a novel member of the FYVE-finger family of proteins, is a specific spastin-binding protein.	Hereditary Spastic Paraplegia	None	Homo sapiens (Human);Homo sapiens (Human)	Protrudin;Spastin	ZFYVE27;SPAST	SPG33;ADPSP FSP2 KIAA1083 SPG4
6571	KCNE1-KCNH2 complex	Human	Mink-ERG complex	transfected CHO cells	P15382;Q12809	3753;3757	MI:0004-affinity chromatography technology	GO:0086008;GO:0071805;GO:0005249;GO:0008076	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization;potassium ion transmembrane transport;voltage-gated potassium channel activity;voltage-gated potassium channel complex	None	None	9230439	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Potassium voltage-gated channel subfamily E member 1;Potassium voltage-gated channel subfamily H member 2	KCNE1;KCNH2	None;ERG ERG1 HERG
6577	3M complex	Human	CUL7-CCDC8-OBSL1-CUL9-p53-ROC1-FBXW8 complex	293T cells	O75147;P04637;P62877;Q14999;Q8IWT3;Q8N3Y1;Q9H0W5	23363;7157;9978;9820;23113;26259;83987	MI:0019-coimmunoprecipitation;MI:0071-molecular sieving	GO:0000226	microtubule cytoskeleton organization	42.04.05	microtubule cytoskeleton	24793695	None	Besides CUL7, two additional genes, OBSL1 and CCDC8, have been foundto be mutated in 3M syndrome. These three genes are mutated in a mutually exclusive manner, with CUL7 being the most frequently mutated (~65%), followed by OBSL1 (~30%) and CCDC8 (~5%).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Obscurin-like protein 1;Cellular tumor antigen p53;E3 ubiquitin-protein ligase RBX1;Cullin-7;Cullin-9;F-box/WD repeat-containing protein 8;Coiled-coil domain-containing protein 8	OBSL1;TP53;RBX1;CUL7;CUL9;FBXW8;CCDC8	KIAA0657;P53;RNF75 ROC1;KIAA0076;H7AP1 KIAA0708 PARC;FBW6 FBW8 FBX29 FBXO29 FBXW6;None
6578	KCNE2-KCNH2 complex	Human	ATFB4-ERG complex	in vitro	Q12809;Q9Y6J6	3757;9992	MI:0004-affinity chromatography technology	GO:0086008;GO:0008076;GO:0005249;GO:0071805	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization;voltage-gated potassium channel complex;voltage-gated potassium channel activity;potassium ion transmembrane transport	None	None	10219239	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Potassium voltage-gated channel subfamily H member 2;Potassium voltage-gated channel subfamily E member 2	KCNH2;KCNE2	ERG ERG1 HERG;None
6579	USF1-USF2 complex	Human	None	None	P22415;Q15853	7391;7392	MI:0019-coimmunoprecipitation	GO:0006357;GO:0000981	regulation of transcription by RNA polymerase II;DNA-binding transcription factor activity, RNA polymerase II-specific	None	None	14573800	None	Varicella-zoster virus infection.	None	Homo sapiens (Human);Homo sapiens (Human)	Upstream stimulatory factor 1;Upstream stimulatory factor 2	USF1;USF2	BHLHB11 USF;BHLHB12
6581	LRRC8A-LRRC8C complex	Human	None	HeLa cells	Q8IWT6;Q8TDW0	56262;84230	MI:0019-coimmunoprecipitation	GO:0006884;GO:0005225	cell volume homeostasis;volume-sensitive anion channel activity	None	None	26824658	For full channel activity LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E) is necessary. LRRC8C-E subunits associated with SWELL1 (LRRC8A) contribute to ion selectivity.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Volume-regulated anion channel subunit LRRC8A;Volume-regulated anion channel subunit LRRC8C	LRRC8A;LRRC8C	KIAA1437 LRRC8 SWELL1;AD158 FAD158
6582	LRRC8A-LRRC8D complex	Human	None	HeLa cells	Q7L1W4;Q8IWT6	55144;56262	MI:0019-coimmunoprecipitation	GO:0006884;GO:0005225	cell volume homeostasis;volume-sensitive anion channel activity	None	None	26824658	For full channel activity LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E) is necessary. LRRC8C-E subunits associated with SWELL1 (LRRC8A) contribute to ion selectivity.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Volume-regulated anion channel subunit LRRC8D;Volume-regulated anion channel subunit LRRC8A	LRRC8D;LRRC8A	LRRC5;KIAA1437 LRRC8 SWELL1
6583	LRRC8A-LRRC8E complex	Human	None	HeLa cells	Q6NSJ5;Q8IWT6	80131;56262	MI:0007-anti tag coimmunoprecipitation;MI:0071-molecular sieving	GO:0006884;GO:0005225	cell volume homeostasis;volume-sensitive anion channel activity	None	None	26824658	For full channel activity LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E) is necessary. LRRC8C-E subunits associated with SWELL1 (LRRC8A) contribute to ion selectivity.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Volume-regulated anion channel subunit LRRC8E;Volume-regulated anion channel subunit LRRC8A	LRRC8E;LRRC8A	None;KIAA1437 LRRC8 SWELL1
6584	CHRNA9-CHRNA10 complex	Human	None	None	Q9GZZ6;Q9UGM1	57053;55584	MI:0045-experimental interaction detection	GO:0022848;GO:0010996	acetylcholine-gated cation-selective channel activity;response to auditory stimulus	None	None	11752216	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Neuronal acetylcholine receptor subunit alpha-10;Neuronal acetylcholine receptor subunit alpha-9	CHRNA10;CHRNA9	NACHRA10;NACHRA9
6585	Intraflagellar transport complex A	Human	IFT-A complex	telomerase immortalized hTERT RPE-1 cells	Q7Z4L5;Q8NEZ3;Q96RY7;Q9HBG6;Q9P2L0	79809;57728;9742;55764;57539	MI:0676-tandem affinity purification	GO:0005929;GO:0035721;GO:0007224;GO:0042073;GO:0060271	cilium;intraciliary retrograde transport;smoothened signaling pathway;intraciliary transport;cilium assembly	30.05.02.16	hedgehog-dependent signalling pathway	20889716	Soluble and membrane proteins are transported along the primary cilium by the IFT machinery. IFT is highly conserved and is required for the assembly of cilia. It is formed of two multisubunit complexes: IFT-A and IFT-B (PMID: 28624967).Ciliogenesis and cilia-mediated signaling both require the function of the intraflagellar transport system (PMID: 35740972).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Tetratricopeptide repeat protein 21B;WD repeat-containing protein 19;Intraflagellar transport protein 140 homolog;Intraflagellar transport protein 122 homolog;WD repeat-containing protein 35	TTC21B;WDR19;IFT140;IFT122;WDR35	IFT139 KIAA1992;IFT144 KIAA1638;KIAA0590 WDTC2;SPG WDR10 WDR140;IFT121, KIAA1336
6586	VEcad-VEGFR complex	Human	None	HUVEC cells	P33151;P35916;P35968	1003;2324;3791	MI:0019-coimmunoprecipitation	GO:1900746;GO:0097704	regulation of vascular endothelial growth factor signaling pathway;cellular response to oscillatory fluid shear stress	None	None	25800053	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cadherin-5;Vascular endothelial growth factor receptor 3;Vascular endothelial growth factor receptor 2	CDH5;FLT4;KDR	None;VEGFR3;FLK1 VEGFR2
6587	CAP-cbl-flotilin complex	Human	None	HEK293T complex	O75955;P22681;Q9BX66	10211;867;10580	MI:0004-affinity chromatography technology	GO:0046324	regulation of glucose import	None	None	11001060	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Flotillin-1;E3 ubiquitin-protein ligase CBL;Sorbin and SH3 domain-containing protein 1	FLOT1;CBL;SORBS1	None;CBL2 RNF55;KIAA0894 KIAA1296 SH3D5
6588	E2F-1-DP-1 complex	Human	E2F1-TFDP1 complex	HeLa cells	Q01094;Q14186	1869;7027	MI:0004-affinity chromatography technology	None	None	None	None	7969176	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Transcription factor E2F1;Transcription factor Dp-1	E2F1;TFDP1	RBBP3;DP1
6589	E2F-1-DP-1-cyclinA-CDK2 complex	Human	None	None	P24941;P78396;Q01094;Q14186	1017;8900;1869;7027	MI:0004-affinity chromatography technology	GO:0003677;GO:0006355	DNA binding;regulation of DNA-templated transcription	16.03.01;11.02.03.04	DNA binding;transcriptional control	7969176	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cyclin-dependent kinase 2;Cyclin-A1;Transcription factor E2F1;Transcription factor Dp-1	CDK2;CCNA1;E2F1;TFDP1	CDKN2;None;RBBP3;DP1
6590	FOXO3-CBP complex	Human	None	None	O43524;Q92793	2309;1387	MI:0077-nuclear magnetic resonance	GO:0003713	transcription coactivator activity	None	None	22474372	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Forkhead box protein O3;CREB-binding protein	FOXO3;CREBBP	FKHRL1, FOXO3A;CBP
6591	Hsp90-p23 complex	Human	None	None	P07900;Q15185	3320;10728	MI:0019-coimmunoprecipitation;MI:0069-mass spectrometry studies of complexes	None	None	None	None	16403413	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Heat shock protein HSP 90-alpha;Prostaglandin E synthase 3	HSP90AA1;PTGES3	HSP90A HSPC1 HSPCA;P23 TEBP
6592	c-Abl-CAS-Abi1 complex	Human	None	airway smooth muscle cells	P00519;P56945;Q8IZP0	25;9564;10006	MI:0019-coimmunoprecipitation	GO:0006940	regulation of smooth muscle contraction	None	None	23740246	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Tyrosine-protein kinase ABL1;Breast cancer anti-estrogen resistance protein 1;Abl interactor 1	ABL1;BCAR1;ABI1	ABL, JTK7;CAS CASS1 CRKAS;SSH3BP1
6594	CCP110-CEP290 complex	Human	None	Human 293T cells	O15078;O43303	80184;9738	MI:0019-coimmunoprecipitation	GO:0060271	cilium assembly	None	None	18694559	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Centrosomal protein of 290 kDa;Centriolar coiled-coil protein of 110 kDa	CEP290;CCP110	BBS14 KIAA0373 NPHP6;CEP110 CP110 KIAA0419
6597	CEP290-IQCB1 complex	Human	CEP290-NPHP5 complex	HEK293 cells	O15078;Q15051	80184;9657	MI:0019-coimmunoprecipitation	GO:0060271;GO:0005813	cilium assembly;centrosome	70.05	centrosome	23446637	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Centrosomal protein of 290 kDa;IQ calmodulin-binding motif-containing protein 1	CEP290;IQCB1	BBS14 KIAA0373 NPHP6;KIAA0036 NPHP5
6598	CC2D2A-CEP290 complex	Human	None	in vitro	O15078;Q9P2K1	80184;57545	MI:0018-two hybrid;MI:0096-pull down	GO:0036064;GO:0005929;GO:0060271	ciliary basal body;cilium;cilium assembly	None	None	18950740	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Centrosomal protein of 290 kDa;Coiled-coil and C2 domain-containing protein 2A	CEP290;CC2D2A	BBS14 KIAA0373 NPHP6;KIAA1345
6599	CTNND1-GLIS2 complex	Human	None	HEK293 cells	O60716;Q9BZE0	1500;84662	MI:0018-two hybrid;MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0005634;GO:0006355	nucleus;regulation of DNA-templated transcription	70.10;11.02.03.04	nucleus;transcriptional control	17344476	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Catenin delta-1;Zinc finger protein GLIS2	CTNND1;GLIS2	KIAA0384;NKL
6600	NPHP1-PKD1 complex	Human	None	HEK293 cells	O15259;P98161	4867;5310	MI:0019-coimmunoprecipitation	GO:0006915;GO:0060271	apoptotic process;cilium assembly	40.10.02	apoptosis (type I programmed cell death)	20856870	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Nephrocystin-1;Polycystin-1	NPHP1;PKD1	NPH1;None
6601	BBS1-BBS4-BBS5-PKD1-TTC8 complex	Human	BBS1-BBS4-BBS5-PKD1-BBS8 complex	HEK293 cells	P98161;Q8N3I7;Q8NFJ9;Q8TAM2;Q96RK4	5310;129880;582;123016;585	MI:0018-two hybrid;MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0005929;GO:0042073	cilium;intraciliary transport	None	None	24939912	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Polycystin-1;Bardet-Biedl syndrome 5 protein;Bardet-Biedl syndrome 1 protein;Tetratricopeptide repeat protein 8;Bardet-Biedl syndrome 4 protein	PKD1;BBS5;BBS1;TTC8;BBS4	None;None;BBS2L2;BBS8;None
6602	AP5-SPG11-SPG15 complex	Human	AP5Z1-AP5B1- AP5M1-AP5S1-SPG11-SPG15 complex	HeLa cells	O43299;Q2VPB7;Q68DK2;Q96JI7;Q9H0R1;Q9NUS5	9907;91056;23503;80208;55745;55317	MI:0019-coimmunoprecipitation	GO:0005768;GO:0005764;GO:0044599;GO:0005794;GO:0006886;GO:0006605;GO:0030133	endosome;lysosome;AP-5 adaptor complex;Golgi apparatus;intracellular protein transport;protein targeting;transport vesicle	70.22;70.25;70.08;14.04;70.09	endosome;vacuole or lysosome;Golgi;protein targeting, sorting and translocation;intracellular transport vesicles	23825025	AP-5 complex (constisting of  AP5Z1, AP5B1, AP5M1, and AP5S1) is a recently identified but evolutionarily ancient member oft he family of heterotetrameric adaptor proteins (AP complexes). It is associated with the two proteins SPG11 and SPG15. AP-5, SPG11, and SPG15 colocalize on a late endosomal/lysosomal compartment. Both SPG11 and SPG15 have predicted secondary structures containing alpha-solenoids related to those of clathrin heavy chain and COPI subunits. SPG11 also has an N-terminal, beta-propeller\u2013like domain, which interacts in vitro with AP-5. It is proposed that AP-5, SPG15, and SPG11 form a coat-like complex, with AP-5 involved in protein sorting, SPG15 facilitating the docking of the coat onto membranes by interacting with PI3P via its FYVE domain, and SPG11 (possibly together with SPG15) forming a scaffold.	SPG11 (ALS5) and SPG15 (ZFYVE26) are mutated in patients with hereditary spastic paraplegia (HSP).	The four AP-5 subunits can be coimmunoprecipitated with SPG11 andSPG15, both from cytosol and from detergent-extracted membranes, with a stoichiometry of 1:1:1:1:1:1.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	AP-5 complex subunit zeta-1;AP-5 complex subunit beta-1;Zinc finger FYVE domain-containing protein 26;Spatacsin;AP-5 complex subunit mu-1;AP-5 complex subunit sigma-1	AP5Z1;AP5B1;ZFYVE26;SPG11;AP5M1;AP5S1	KIAA0415 SPG48;None;KIAA0321;KIAA1840;C14orf108,MUDENG;C20orf29
6603	ANKRA2-CCDC8-OBSL1-CUL7 complex	Human	None	HEK 293 cells	O75147;Q14999;Q9H0W5;Q9H9E1	23363;9820;83987;57763	MI:0007-anti tag coimmunoprecipitation	None	None	None	None	25752541	These results indicate that OBSL1 serves as a scaffold to bridge interaction ofCUL7 with CCDC8, which in turn associates with ANKRA2.	The CCDC8, CUL7, and OBSL1 genes are mutated in patients with 3M syndrome. The unexpected identification of CCDC8 as a major partner of ANKRA2 suggests an important role of ANKRA2 in 3M syndrome.	ANKRA2 inhibits CUL7 interaction with HDAC4/5.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Obscurin-like protein 1;Cullin-7;Coiled-coil domain-containing protein 8;Ankyrin repeat family A protein 2	OBSL1;CUL7;CCDC8;ANKRA2	KIAA0657;KIAA0076;None;ANKRA
6609	ATL2-ZFYVE27 complex	Human	Protrudin-Atlastin2 complex; ATL2-SPG33 complex	HeLa cells; HEK293T cells	Q5T4F4;Q8NHH9	118813;64225	MI:0019-coimmunoprecipitation	GO:0005783;GO:0071787;GO:0071788;GO:0016192	endoplasmic reticulum;endoplasmic reticulum tubular network formation;endoplasmic reticulum tubular network maintenance;vesicle-mediated transport	70.07;20.09.07	endoplasmic reticulum;vesicular transport (Golgi network, etc.)	23969831	Protrudin binds all three human atlastins (atlastin-1, atlastin-2, and atlastin-3) and endoplasmic reticulum-shaping proteins and regulates network formation. The interaction with atlastins required protrudin residues 1-205.	The protrudin gene (ZFYVE27) is mutated in a subset of individuals with hereditary spastic paraplegia (HSP), and protrudin is therefore also referred to as spastic paraplegia 33 (SPG33). It is suggested that protrudin contributes to the regulation of ER morphology and function, and that its deregulation by mutation is a causative defect in HSP (PMID:24668814).	None	Homo sapiens (Human);Homo sapiens (Human)	Protrudin;Atlastin-2	ZFYVE27;ATL2	SPG33;ARL6IP2
6611	NECTIN1-PDZD11 complex	Human	None	colon carcinoma cells	Q15223;Q5EBL8	5818;51248	MI:0019-coimmunoprecipitation	GO:0055074	calcium ion homeostasis	None	None	27044745	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Nectin-1;PDZ domain-containing protein 11	NECTIN1;PDZD11	HVEC PRR1 PVRL1;AIPP1 PDZK11 PISP
6612	PDZD11-nectin3 complex	Human	None	None	Q5EBL8;Q9NQS3	51248;25945	MI:0019-coimmunoprecipitation	GO:0055074	calcium ion homeostasis	None	None	27044745	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	PDZ domain-containing protein 11;Nectin-3	PDZD11;NECTIN3	AIPP1 PDZK11 PISP;PRR3,PVRL3
6613	ATL3-ZFYVE27 complex	Human	Protrudin-Atlastin3 complex; ATL3-SPG33 complex	HeLa cells; HEK293T cells	Q5T4F4;Q6DD88	118813;25923	MI:0019-coimmunoprecipitation	GO:0005783;GO:0071787;GO:0071788;GO:0016192	endoplasmic reticulum;endoplasmic reticulum tubular network formation;endoplasmic reticulum tubular network maintenance;vesicle-mediated transport	70.07;20.09.07	endoplasmic reticulum;vesicular transport (Golgi network, etc.)	23969831	Protrudin binds all three human atlastins (atlastin-1, atlastin-2, and atlastin-3) and endoplasmic reticulum-shaping proteins and regulates network formation. The interaction with atlastins required protrudin residues 1-205.	The protrudin gene (ZFYVE27) is mutated in a subset of individuals with hereditary spastic paraplegia (HSP), and protrudin is therefore also referred to as spastic paraplegia 33 (SPG33). It is suggested that protrudin contributes to the regulation of ER morphology and function, and that its deregulation by mutation is a causative defect in HSP (PMID:24668814).	None	Homo sapiens (Human);Homo sapiens (Human)	Protrudin;Atlastin-3	ZFYVE27;ATL3	SPG33;None
6615	RNT2-SPAST complex	Human	SPG4-SPG12 complex	HeLa cells	O75298;Q9UBP0	6253;6683	MI:0019-coimmunoprecipitation	GO:0007029;GO:0005874	endoplasmic reticulum organization;microtubule	42.07	endoplasmic reticulum	22232211	It is shown that the RTN2/SPG12 protein interacts with spastin and that this interaction requires sequences of the spastin protein that contain the predicted hairpin membrane domain.	Mutations in the ER-shaping protein reticulon 2 cause the axon-degenerative disorder hereditary spastic paraplegia type 12 (SPG12).	None	Homo sapiens (Human);Homo sapiens (Human)	Reticulon-2;Spastin	RTN2;SPAST	NSPL1;ADPSP FSP2 KIAA1083 SPG4
6616	CADM1-4.1B-MPP3 complex	Human	CADM1-EPB41L3-MPP3 complex	None	Q13368;Q9BY67;Q9Y2J2	4356;23705;23136	MI:0051-fluorescence technology	None	None	None	None	25780926	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	MAGUK p55 subfamily member 3;Cell adhesion molecule 1;Band 4.1-like protein 3	MPP3;CADM1;EPB41L3	DLG3;IGSF4 IGSF4A NECL2 SYNCAM TSLC1;DAL1 KIAA0987
6617	NF2-WWC1 complex	Human	KIBRA-Merlin complex	HEK293 cells	P35240;Q8IX03	4771;23286	MI:0019-coimmunoprecipitation	GO:0035329	hippo signaling	None	None	20159599	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Merlin;Protein KIBRA	NF2;WWC1	SCH;KIAA0869
6618	RhBG-kAE1-ankyrin-G complex	Human	None	Kidney epithelial cells	P02730;Q12955;Q9H310	6521;288;57127	MI:0004-affinity chromatography technology	None	None	None	None	25616663	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Band 3 anion transport protein;Ankyrin-3;Ammonium transporter Rh type B	SLC4A1;ANK3;RHBG	AE1 DI EPB3;None;None
6619	MGAT1-NGT complex	Human	MGAT1-SLC35A3 complex	HEK293T cells	P26572;Q9Y2D2	4245;23443	MI:0053-fluorescence polarization spectroscopy;MI:0055-fluorescent resonance energy transfer	GO:1990569;GO:0000139	UDP-N-acetylglucosamine transmembrane transport;Golgi membrane	None	None	25944901	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase;UDP-N-acetylglucosamine transporter	MGAT1;SLC35A3	GGNT1 GLCT1 GLYT1 MGAT;None
6620	MGAT1-SLC35A2(splice variant 2) complex	Human	Mgat1-UGT1 complex	HEK293T cells	P26572;P78381-2	4245;7355	MI:0053-fluorescence polarization spectroscopy;MI:0055-fluorescent resonance energy transfer	GO:0072334;GO:0000139	UDP-galactose transmembrane transport;Golgi membrane	None	None	25944901	None	None	One of the subunits of this complex is a splice variant 2 of SLC35A2 protein.	Homo sapiens (Human);Homo sapiens (Human)	Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase;Isoform 2 of UDP-galactose translocator	MGAT1;SLC35A2	GGNT1 GLCT1 GLYT1 MGAT;UGALT UGT UGTL
6621	NEK2-SAV1-STK3 complex	Human	NEK2A-SAV1-MST2 complex	HEK293 cells	P51955;Q13188;Q9H4B6	4751;6788;60485	MI:0018-two hybrid;MI:0019-coimmunoprecipitation	GO:0051225;GO:0035329;GO:0051299;GO:0007098	spindle assembly;hippo signaling;centrosome separation;centrosome cycle	10.03.05.01	spindle pole body/centrosome and microtubule cycle	21076410	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein kinase Nek2;Serine/threonine-protein kinase 3;Protein salvador homolog 1	NEK2;STK3;SAV1	NEK2A NLK1;KRS1, MST2;WW45
6622	MGAT2-SLC35A3 complex	Human	MGAT2-NGT complex	HEK293T	Q10469;Q9Y2D2	4247;23443	MI:0053-fluorescence polarization spectroscopy;MI:0055-fluorescent resonance energy transfer	GO:1990569;GO:0000139	UDP-N-acetylglucosamine transmembrane transport;Golgi membrane	None	None	25944901	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase;UDP-N-acetylglucosamine transporter	MGAT2;SLC35A3	None;None
6623	MGAT2-SLC35A2(splice variant 2) complex	Human	MGAT2-UGT1 complex	None	P78381-2;Q10469	7355;4247	MI:0053-fluorescence polarization spectroscopy;MI:0055-fluorescent resonance energy transfer	GO:0072334;GO:0000139	UDP-galactose transmembrane transport;Golgi membrane	None	None	25944901	None	None	One of the subunits of this complex is a splice variant 2 of SLC35A2 protein.	Homo sapiens (Human);Homo sapiens (Human)	Isoform 2 of UDP-galactose translocator;Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	SLC35A2;MGAT2	UGALT UGT UGTL;None
6624	MGAT4B-SLC35A3 complex	Human	MGAT4B-NGT complex	HEK293T cells	Q9UQ53;Q9Y2D2	11282;23443	MI:0053-fluorescence polarization spectroscopy;MI:0055-fluorescent resonance energy transfer	GO:1990569;GO:0000139	UDP-N-acetylglucosamine transmembrane transport;Golgi membrane	None	None	25944901	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B;UDP-N-acetylglucosamine transporter	MGAT4B;SLC35A3	None;None
6625	MGAT4B-SLC35A2(splice variant 1) complex	Human	MGAT4B-UGT2 complex	HEK93T cells	P78381-1;Q9UQ53	7355;11282	MI:0053-fluorescence polarization spectroscopy;MI:0055-fluorescent resonance energy transfer	GO:0072334;GO:0000139	UDP-galactose transmembrane transport;Golgi membrane	None	None	25944901	None	None	One of the subunits in this complex is a splice varient 1 of SLC35A2 protein.	Homo sapiens (Human);Homo sapiens (Human)	Isoform 1 of UDP-galactose translocator;Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B	SLC35A2;MGAT4B	UGALT UGT UGTL;None
6626	AP5 adaptor complex	Human	AP-5 adaptor complex	HeLa cells	O43299;Q2VPB7;Q9H0R1;Q9NUS5	9907;91056;55745;55317	MI:0019-coimmunoprecipitation	GO:0044599;GO:0005768;GO:0005764;GO:0005794;GO:0006886;GO:0030133;GO:0006605;GO:0015031	AP-5 adaptor complex;endosome;lysosome;Golgi apparatus;intracellular protein transport;transport vesicle;protein targeting;protein transport	70.22;70.25;70.08;14.04;70.09;20.01.10	endosome;vacuole or lysosome;Golgi;protein targeting, sorting and translocation;intracellular transport vesicles;protein transport	22022230	Adaptor protein (AP) complexes (AP1-5) facilitate the trafficking of cargo from one membrane compartment of the cell to another by recruiting other proteins to particular types of vesicles. All of the AP complexes are involved in post-Golgi trafficking pathways. AP-5 is an evolutionarily ancient complex, which is involved in endosomal sorting.	Mutations in AP5Z1,a gene playing a role in intracellular membrane trafficking, have been reported to be associated with spastic paraplegia type 48 (SPG48) (PMID:25333062).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	AP-5 complex subunit zeta-1;AP-5 complex subunit beta-1;AP-5 complex subunit mu-1;AP-5 complex subunit sigma-1	AP5Z1;AP5B1;AP5M1;AP5S1	KIAA0415 SPG48;None;C14orf108,MUDENG;C20orf29
6628	MGAT4B-SLC35A2(splice variant 2) complex	Human	MGAT4B-UGT1 complex	HEK93T cells	P78381-2;Q9UQ53	7355;11282	MI:0053-fluorescence polarization spectroscopy;MI:0055-fluorescent resonance energy transfer	GO:0072334;GO:0000139	UDP-galactose transmembrane transport;Golgi membrane	None	None	25944901	None	None	One of the subunits in this complex is a splice variant 1 of SLC35A2 protein.	Homo sapiens (Human);Homo sapiens (Human)	Isoform 2 of UDP-galactose translocator;Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B	SLC35A2;MGAT4B	UGALT UGT UGTL;None
6629	MAGT5-SLC35A3 complex	Human	MAGT5-NGT complex	HEK93T cells	Q09328;Q9Y2D2	4249;23443	MI:0053-fluorescence polarization spectroscopy;MI:0053-fluorescence polarization spectroscopy	GO:1990569;GO:0000139	UDP-N-acetylglucosamine transmembrane transport;Golgi membrane	None	None	25944901	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A;UDP-N-acetylglucosamine transporter	MGAT5;SLC35A3	GGNT5;None
6630	MGAT5-SLC352A(splice variant 2) complex	Human	MGAT5-UGT1 complex	HEK293T cells	P78381-2;Q09328	7355;4249	MI:0053-fluorescence polarization spectroscopy;MI:0055-fluorescent resonance energy transfer	GO:1990569;GO:0000139	UDP-N-acetylglucosamine transmembrane transport;Golgi membrane	None	None	25944901	None	None	One of the subunits in this complex is a splice variant 2of SLC35A2 protein.	Homo sapiens (Human);Homo sapiens (Human)	Isoform 2 of UDP-galactose translocator;Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A	SLC35A2;MGAT5	UGALT UGT UGTL;GGNT5
6634	WDR20-USP12-UAF1 complex	Human	None	HeLa cells	O75317;Q8TAF3;Q8TBZ3	219333;57599;91833	MI:0007-anti tag coimmunoprecipitation	GO:0016579	protein deubiquitination	14.07.05	modification by ubiquitination, deubiquitination	20147737	WDR20 has a stimulatory activity to the USP12\u00b7UAF1 complex. It is speculated that WDR20 serves as a specific adaptor subunit for recruiting specific substrates. This complex is not involved in the Fanconi anemia  DNA repair pathway.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Ubiquitin carboxyl-terminal hydrolase 12;WD repeat-containing protein 48;WD repeat-containing protein 20	USP12;WDR48;WDR20	UBH1 USP12L1;KIAA1449, UAF1;None
6635	WDR20-USP46-UAF1 complex	Human	None	HeLa cells	P62068;Q8TAF3;Q8TBZ3	64854;57599;91833	MI:0007-anti tag coimmunoprecipitation	GO:0016579	protein deubiquitination	14.07.05	modification by ubiquitination, deubiquitination	20147737	This complex is not involved in the Fanconi anemia DNA repair pathway.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Ubiquitin carboxyl-terminal hydrolase 46;WD repeat-containing protein 48;WD repeat-containing protein 20	USP46;WDR48;WDR20	None;KIAA1449, UAF1;None
6636	USP12-UAF1 complex	Human	None	HeLa cells	O75317;Q8TAF3	219333;57599	MI:0007-anti tag coimmunoprecipitation;MI:0027-cosedimentation	GO:0005634;GO:0016579	nucleus;protein deubiquitination	70.10;14.07.05	nucleus;modification by ubiquitination, deubiquitination	19075014	The complex is not involved in the regulation of the Fanconi anemia pathway.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Ubiquitin carboxyl-terminal hydrolase 12;WD repeat-containing protein 48	USP12;WDR48	UBH1 USP12L1;KIAA1449, UAF1
6637	USP46-UAF1 complex	Human	None	HeLa cells	P62068;Q8TAF3	64854;57599	MI:0007-anti tag coimmunoprecipitation;MI:0027-cosedimentation	GO:0016579;GO:0005634	protein deubiquitination;nucleus	14.07.05;70.10	modification by ubiquitination, deubiquitination;nucleus	19075014	This complex is not involved in the regulation of the Fanconi anemia pathway.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Ubiquitin carboxyl-terminal hydrolase 46;WD repeat-containing protein 48	USP46;WDR48	None;KIAA1449, UAF1
6639	CCC-Wash (WASH1, FAM21C) complex	Human	CCC (COMMDs1-10, CCDC22, CCDC93)-C16orf62-WASH (WASH1, FAM21C) complex	HEK293T cells; HeLa cells	A8K0Z3;O60826;Q567U6;Q7Z3J2;Q7Z4G1;Q86VX2;Q86X83;Q8N668;Q9GZQ3;Q9H0A8;Q9NX08;Q9P000;Q9UBI1;Q9Y4E1;Q9Y6G5	100287171;28952;54520;57020;170622;149951;51122;150684;28991;54939;54951;29099;23412;253725;51397	MI:0019-coimmunoprecipitation;MI:0051-fluorescence technology	GO:0031941;GO:0035459;GO:0071203;GO:0055070	filamentous actin;vesicle cargo loading;WASH complex;copper ion homeostasis	None	None	25355947	All 10 human COMMD family members coprecipitated endogenous CCDC93. The interaction experiments validated the notion that these factors form a multiprotein complex. COMMD1 is directly linked to early endosomes through its interaction with a protein complex containing CCDC22, CCDC93, and C16orf62. This COMMD/CCDC22/CCDC93 (CCC) complex interacts with the multisubunit WASH complex, an evolutionarily conserved system, which is required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. Interactions between the WASH complex subunit FAM21, and the carboxyl-terminal ends of CCDC22 and CCDC93 are responsible for CCC complex recruitment to endosomes. In the absence of the CCC complex or its recruitment to endosomes, ATP7A is mislocalized and does not traffic in response to copper availability, resulting in altered copper handling.	Depletion of CCC complex components leads to lack of copper-dependent movement of the copper transporter ATP7A from endosomes, resulting in intracellular copper accumulation and modest alterations in copper homeostasis in humans with CCDC22 mutations.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	WASH complex subunit 1;Coiled-coil domain-containing protein 22;Coiled-coil domain-containing protein 93;VPS35 endosomal protein-sorting factor-like;COMM domain-containing protein 6;COMM domain-containing protein 7;COMM domain-containing protein 2;COMM domain-containing protein 1;COMM domain-containing protein 5;COMM domain-containing protein 4;COMM domain-containing protein 8;COMM domain-containing protein 9;COMM domain-containing protein 3;WASH complex subunit 2C;COMM domain-containing protein 10	WASHC1;CCDC22;CCDC93;VPS35L;COMMD6;COMMD7;COMMD2;COMMD1;COMMD5;COMMD4;COMMD8;COMMD9;COMMD3;WASHC2C;COMMD10	FAM39E WASH1;CXorf37;None;C16orf62;None;C20orf92;None;C2orf5, MURR1;None;None;None;None;BUP C10orf8;FAM21C KIAA0592 VPEF;None
6640	Phosphorylase kinase complex	Human	PHKA1-PHKB-PHKG1-CALM1 complex	None	P0DP23;P46020;Q16816;Q93100	801;5255;5260;5257	MI:0069-mass spectrometry studies of complexes	GO:0005977	glycogen metabolic process	01.05.03.01	glycogen metabolism	22964223	None	None	P62158 is obsolete. On May 10, 2017 this ID became obsolete. It can now be found as secondary accession in P0DP23, P0DP24 and P0DP25.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Calmodulin-1;Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform;Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform;Phosphorylase b kinase regulatory subunit beta	CALM1;PHKA1;PHKG1;PHKB	CALM CAM CAM1;PHKA;PHKG;None
6641	USP22-SAGA complex	Human	hSAGA transcriptional cofactor complex; SAGA transcription coactivator HAT complex; Histone acetyltransferase complex USP22-SAGA	H1299 cells (lung cancer cell line)	O75528;Q12962;Q14CW9;Q86TJ2;Q92830;Q9HBM6;Q9UPT9;Q9Y4A5	10474;6881;56970;93624;2648;51616;23326;8295	MI:0004-affinity chromatography technology	GO:0005634;GO:0004402;GO:1902562;GO:0016578;GO:0010564;GO:0009299	nucleus;histone acetyltransferase activity;H4 histone acetyltransferase complex;histone deubiquitination;regulation of cell cycle process;mRNA transcription	70.10;11.02.03	nucleus;mRNA synthesis	18206973	None	USP22 is a cancer stem cell marker and is required for the biological activity of the MYC oncoprotein.	The authors did not specify ADA2, but according to PMID:26468280 the subunit of the SAGA complex is ADA2B.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transcriptional adapter 3;Transcription initiation factor TFIID subunit 10;Ataxin-7-like protein 3;Transcriptional adapter 2-beta;Histone acetyltransferase KAT2A;Transcription initiation factor TFIID subunit 9B;Ubiquitin carboxyl-terminal hydrolase 22;Transformation/transcription domain-associated protein	TADA3;TAF10;ATXN7L3;TADA2B;KAT2A;TAF9B;USP22;TRRAP	ADA3 TADA3L;TAF2A TAF2H TAFII30;None;ADA2B;GCN5 GCN5L2;TAF9L;KIAA1063,USP3L;PAF400
6642	ODC-OAZ1-CCND1 complex	Human	ODC-AZ-CCND1	None	P11926;P24385;P54368	4953;595;4946	MI:0028-cosedimentation in solution	GO:0030163	protein catabolic process	14.13	protein/peptide degradation	26172301	The authors found that the ODC-AZ-CCND1 ternary complex may exist in equilibrium and that the AZ-mediated degradation of ODC and CCND1 is inhibited by ternary complex formation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Ornithine decarboxylase;G1/S-specific cyclin-D1;Ornithine decarboxylase antizyme 1	ODC1;CCND1;OAZ1	None;BCL1 PRAD1;OAZ
6643	SAGA complex, GCN5-linked	Human	Histone acetyltransferase (HAT) complex SAGA	HeLa cells	O75486;O75528;O75529;O94864;P00813;Q12962;Q14CW9;Q16514;Q16594;Q5T6C5;Q86TJ2;Q8NEM7;Q92830;Q96ES7;Q9HBM6;Q9ULK2;Q9UPT9;Q9Y4A5;Q9Y6J9	8464;10474;27097;9913;100;6881;56970;6883;6880;127002;93624;55578;2648;112869;51616;222255;23326;8295;10629	MI:0019-coimmunoprecipitation;MI:0676-tandem affinity purification	GO:0016573;GO:0005634;GO:0044154	histone acetylation;nucleus;histone H3-K14 acetylation	70.10	nucleus	26468280	None	None	It is not clear whether ATXN7 (O15265) is also a subunit of the complex.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transcription initiation protein SPT3 homolog;Transcriptional adapter 3;TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L;STAGA complex 65 subunit gamma;Adenosine deaminase;Transcription initiation factor TFIID subunit 10;Ataxin-7-like protein 3;Transcription initiation factor TFIID subunit 12;Transcription initiation factor TFIID subunit 9;Ataxin-7-like protein 2;Transcriptional adapter 2-beta;Transcription factor SPT20 homolog;Histone acetyltransferase KAT2A;SAGA-associated factor 29;Transcription initiation factor TFIID subunit 9B;Ataxin-7-like protein 1;Ubiquitin carboxyl-terminal hydrolase 22;Transformation/transcription domain-associated protein;TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L	SUPT3H;TADA3;TAF5L;SUPT7L;ADA;TAF10;ATXN7L3;TAF12;TAF9;ATXN7L2;TADA2B;SUPT20H;KAT2A;SGF29;TAF9B;ATXN7L1;USP22;TRRAP;TAF6L	SPT3;ADA3 TADA3L;PAF65B;KIAA0764;ADA1;TAF2A TAF2H TAFII30;None;TAF15 TAF2J TAFII20;TAF2G TAFII31;None;ADA2B;C13orf19 FAM48A;GCN5 GCN5L2;CCDC101;TAF9L;ATXN7L4,KIAA1218;KIAA1063,USP3L;PAF400;PAF65A
6644	CCDC22-COMMD1-CUL2 complex	Human	CCDC22-MURR1-CUL2 complex	HEK 293 cells	O60826;Q13617;Q8N668	28952;8453;150684	MI:0019-coimmunoprecipitation	GO:0016567	protein ubiquitination	14.07.05	modification by ubiquitination, deubiquitination	23563313	It is demonstrated that all COMMD proteins bind to CCDC22. COMMD1 binds preferentially to Cul2, whereas COMMD8 binds better to Cul1 and Cul3. These data suggested that despite the ability of COMMDs, CCDC22, and Cullin to form a triple complex, none of them seems to play a scaffold role. The high level of CCDC22 expression observed in the immune system, particularly in myeloid and T cells, suggests an important immunological role, in keeping with the NFkappaB regulatory function. The involvement of CCDC22 and COMMD8 in the ubiquitination of IkappaB represents a novel aspect in the regulation of this critical pathway that might be amenable to therapeutic manipulation.	CCDC22 is a factor recently implicated in X-linked intellectual disability (XLID). COMMD1 deficiency results in defective copper homeostasis (PMID:25355947).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Coiled-coil domain-containing protein 22;Cullin-2;COMM domain-containing protein 1	CCDC22;CUL2;COMMD1	CXorf37;None;C2orf5, MURR1
6645	CCC complex	Human	CCC (COMMDs1-10, CCDC22, CCDC93, C16orf62) multiprotein complex	HEK293T cells; HeLa cells	O60826;Q567U6;Q7Z3J2;Q7Z4G1;Q86VX2;Q86X83;Q8N668;Q9GZQ3;Q9H0A8;Q9NX08;Q9P000;Q9UBI1;Q9Y6G5	28952;54520;57020;170622;149951;51122;150684;28991;54939;54951;29099;23412;51397	MI:0019-coimmunoprecipitation;MI:0051-fluorescence technology	GO:0005769;GO:0055070	early endosome;copper ion homeostasis	None	None	25355947	All 10 human COMMD family members coprecipitated endogenous CCDC93. The interaction experiments validated the notion that these factors form a multiprotein complex. COMMD1 is directly linked to early endosomes through its interaction with a protein complex containing CCDC22, CCDC93, and C16orf62. In the absence of the CCC complex or its recruitment to endosomes, ATP7A is mislocalized and does not traffic in response to copper availability, resulting in altered copper handling.	Depletion of CCC complex components leads to lack of copper-dependent movement of the copper transporter ATP7A from endosomes, resulting in intracellular copper accumulation and modest alterations in copper homeostasis in humans with CCDC22 mutations.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Coiled-coil domain-containing protein 22;Coiled-coil domain-containing protein 93;VPS35 endosomal protein-sorting factor-like;COMM domain-containing protein 6;COMM domain-containing protein 7;COMM domain-containing protein 2;COMM domain-containing protein 1;COMM domain-containing protein 5;COMM domain-containing protein 4;COMM domain-containing protein 8;COMM domain-containing protein 9;COMM domain-containing protein 3;COMM domain-containing protein 10	CCDC22;CCDC93;VPS35L;COMMD6;COMMD7;COMMD2;COMMD1;COMMD5;COMMD4;COMMD8;COMMD9;COMMD3;COMMD10	CXorf37;None;C16orf62;None;C20orf92;None;C2orf5, MURR1;None;None;None;None;BUP C10orf8;None
6646	SMAD2-SMAD4-WWTR1 complex	Human	SMAD2-SMAD4-TAZ complex	HEK293T cells	Q13485;Q15796;Q9GZV5	4089;4087;25937	MI:0019-coimmunoprecipitation	GO:0006351	DNA-templated transcription	11	TRANSCRIPTION	18568018	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mothers against decapentaplegic homolog 4;Mothers against decapentaplegic homolog 2;WW domain-containing transcription regulator protein 1	SMAD4;SMAD2;WWTR1	DPC4 MADH4;MADH2 MADR2;TAZ
6647	MED15-WWTR1 complex	Human	ARC105-TAZ complex	HEK293T cells	Q96RN5;Q9GZV5	51586;25937	MI:0019-coimmunoprecipitation	GO:0006351	DNA-templated transcription	11	TRANSCRIPTION	18568018	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Mediator of RNA polymerase II transcription subunit 15;WW domain-containing transcription regulator protein 1	MED15;WWTR1	ARC105 CTG7A PCQAP TIG1 TNRC7;TAZ
6648	KCND3-KCNIP4 complex	Human	Kv4.3- KChIP4a complex ;KCND3-KCNIP4(splice variant 4) complex	HEK293 cells	Q6PIL6-4;Q9UK17	80333;3752	MI:0019-coimmunoprecipitation	GO:1901379;GO:0071805;GO:0005249;GO:0008076	regulation of potassium ion transmembrane transport;potassium ion transmembrane transport;voltage-gated potassium channel activity;voltage-gated potassium channel complex	None	None	26039167	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Isoform 4 of Kv channel-interacting protein 4;Potassium voltage-gated channel subfamily D member 3	KCNIP4;KCND3	CALP KCHIP4;None
6649	SMAD3-SMAD4-WWTR1 complex	Human	SMAD3-SMAD4-TAZ complex	HEK293T cells	P84022;Q13485;Q9GZV5	4088;4089;25937	MI:0019-coimmunoprecipitation	GO:0006351	DNA-templated transcription	11	TRANSCRIPTION	18568018	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mothers against decapentaplegic homolog 3;Mothers against decapentaplegic homolog 4;WW domain-containing transcription regulator protein 1	SMAD3;SMAD4;WWTR1	MADH3;DPC4 MADH4;TAZ
6650	KCND3-KCNIP4 complex	Human	Kv4.3-KChIP4bl complex	HEK293 cells	Q6PIL6;Q9UK17	80333;3752	MI:0019-coimmunoprecipitation	GO:1901379;GO:0071805;GO:0005249;GO:0008076	regulation of potassium ion transmembrane transport;potassium ion transmembrane transport;voltage-gated potassium channel activity;voltage-gated potassium channel complex	None	None	26039167	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Kv channel-interacting protein 4;Potassium voltage-gated channel subfamily D member 3	KCNIP4;KCND3	CALP KCHIP4;None
6651	WWTR1-YAP1 complex	Human	TAZ-YAP complex	HEK 293T cells	P46937;Q9GZV5	10413;25937	MI:0019-coimmunoprecipitation	GO:0006351	DNA-templated transcription	11	TRANSCRIPTION	16332960	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Transcriptional coactivator YAP1;WW domain-containing transcription regulator protein 1	YAP1;WWTR1	YAP65;TAZ
6652	WWTR1 homodimer	Human	TAZ homodimer	HEK 293T cells	Q9GZV5	25937	MI:0019-coimmunoprecipitation	GO:0006351	DNA-templated transcription	11	TRANSCRIPTION	16332960	None	None	None	Homo sapiens (Human)	WW domain-containing transcription regulator protein 1	WWTR1	TAZ
6653	EP300-KAT2B-TBX5-WWTR1 complex	Human	P300-PCAF-TBX5-TAZ complex	HEK 293T cells	Q09472;Q92831;Q99593;Q9GZV5	2033;8850;6910;25937	MI:0019-coimmunoprecipitation	GO:0006351	DNA-templated transcription	11	TRANSCRIPTION	16332960	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone acetyltransferase p300;Histone acetyltransferase KAT2B;T-box transcription factor TBX5;WW domain-containing transcription regulator protein 1	EP300;KAT2B;TBX5;WWTR1	P300;PCAF;None;TAZ
6654	KCNJ11-ABCC9 complex	Human	KIR6.2-SUR2A complex	COS cells, cardiomyocytes	O60706;Q14654	10060;3767	MI:0045-experimental interaction detection	GO:1901379	regulation of potassium ion transmembrane transport	None	None	9831708	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	ATP-binding cassette sub-family C member 9;ATP-sensitive inward rectifier potassium channel 11	ABCC9;KCNJ11	SUR2;None
6655	CTNNB1-TBX5-YAP1 complex	Human	None	HEK 293T cells	P35222;P46937;Q99593	1499;10413;6910	MI:0019-coimmunoprecipitation	GO:0006351	DNA-templated transcription	11	TRANSCRIPTION	23245941	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Catenin beta-1;Transcriptional coactivator YAP1;T-box transcription factor TBX5	CTNNB1;YAP1;TBX5	CTNNB;YAP65;None
6657	ATAC complex, GCN5-linked	Human	Histone acetyltransferase (HAT) complex ATAC	HeLa cells	O75478;O75528;P61964;Q01658;Q8IYH5;Q92830;Q96ES7;Q9H8E8;Q9NS73;Q9ULM3	6871;10474;11091;1810;26009;2648;112869;57325;51562;55689	MI:0006-anti bait coimmunoprecipitation;MI:0676-tandem affinity purification	GO:0044154;GO:0005634	histone H3-K14 acetylation;nucleus	70.10	nucleus	26468280	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transcriptional adapter 2-alpha;Transcriptional adapter 3;WD repeat-containing protein 5;Protein Dr1;ZZ-type zinc finger-containing protein 3;Histone acetyltransferase KAT2A;SAGA-associated factor 29;Cysteine-rich protein 2-binding protein;MAP3K12-binding inhibitory protein 1;YEATS domain-containing protein 2	TADA2A;TADA3;WDR5;DR1;ZZZ3;KAT2A;SGF29;KAT14;MBIP;YEATS2	TADA2L;ADA3 TADA3L;BIG3;None;None;GCN5 GCN5L2;CCDC101;CSRP2BP;None;KIAA1197
6658	CCDC22-COMMD8-CUL1 complex	Human	None	HEK 293 cells	O60826;Q13616;Q9NX08	28952;8454;54951	MI:0019-coimmunoprecipitation	GO:0008384;GO:0016567	IkappaB kinase activity;protein ubiquitination	14.07.05	modification by ubiquitination, deubiquitination	23563313	It is demonstrated that all COMMD proteins bind to CCDC22. COMMD1 binds preferentially to Cul2, whereas COMMD8 binds better to Cul1 and Cul3. These data suggested that despite the ability of COMMDs, CCDC22, and Cullin to form a triple complex, none of them seems to play a scaffold role. The high level of CCDC22 expression observed in the immune system, particularly in myeloid and T cells, suggests an important immunological role, in keeping with the NFkappaB regulatory function. The involvement of CCDC22 and COMMD8 in the ubiquitination of IkappaB represents a novel aspect in the regulation of this critical pathway that might be amenable to therapeutic manipulation.	CCDC22 is a factor recently implicated in X-linked intellectual disability (XLID).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Coiled-coil domain-containing protein 22;Cullin-1;COMM domain-containing protein 8	CCDC22;CUL1;COMMD8	CXorf37;None;None
6659	Ubiquitin E3 ligase (CCDC22, COMMD8, CUL3)	Human	None	HEK 293 cells	O60826;Q13618;Q9NX08	28952;8452;54951	MI:0019-coimmunoprecipitation	GO:0016567;GO:0031461	protein ubiquitination;cullin-RING ubiquitin ligase complex	14.07.05	modification by ubiquitination, deubiquitination	23563313	It is demonstrated that all COMMD proteins bind to CCDC22. COMMD1 binds preferentially to Cul2, whereas COMMD8 binds better to Cul1 and Cul3. These data suggested that despite the ability of COMMDs, CCDC22, and Cullin to form a triple complex, none of them seems to play a scaffold role. The high level of CCDC22 expression observed in the immune system, particularly in myeloid and T cells, suggests an important immunological role, in keeping with the NFkappaB regulatory function. The involvement of CCDC22 and COMMD8 in the ubiquitination of IkappaB represents a novel aspect in the regulation of this critical pathway that might be amenable to therapeutic manipulation.	CCDC22 is a factor recently implicated in X-linked intellectual disability (XLID).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Coiled-coil domain-containing protein 22;Cullin-3;COMM domain-containing protein 8	CCDC22;CUL3;COMMD8	CXorf37;KIAA0617;None
6660	LATS1-NPHP4 complex	Human	None	HEK293T cells	O75161;O95835	261734;9113	MI:0019-coimmunoprecipitation	GO:0035329	hippo signaling	None	None	21555462	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Nephrocystin-4;Serine/threonine-protein kinase LATS1	NPHP4;LATS1	KIAA0673;WARTS
6661	NEK8-WWTR1 complex	Human	NPHP9-TAZ complex	HEK293T cells	Q86SG6;Q9GZV5	284086;25937	MI:0019-coimmunoprecipitation	GO:0005634;GO:0035329	nucleus;hippo signaling	70.10	nucleus	23026745	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein kinase Nek8;WW domain-containing transcription regulator protein 1	NEK8;WWTR1	JCK NEK12A;TAZ
6664	STAGA complex, SPT3-linked	Human	HAT complex STAGA; Histone acetyltransferase complex STAGA	HeLa S3 cells; HEK293 cells	O15265;O75486;O75528;O75529;O94864;Q12962;Q14CW9;Q16514;Q16594;Q86TJ2;Q8NEM7;Q92830;Q96BN2;Q96ES7;Q9H0E3;Q9NPA8;Q9UPT9;Q9Y4A5;Q9Y6J9	6314;8464;10474;27097;9913;6881;56970;6883;6880;93624;55578;2648;117143;112869;79595;56943;23326;8295;10629	MI:0007-anti tag coimmunoprecipitation;MI:0096-pull down	GO:0016573;GO:0005634	histone acetylation;nucleus	70.10	nucleus	18838386	None	None	The authors indicate that the interaction of USP22 to ATAC complex is only weak, but is observed under physiological salt concentrations.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Ataxin-7;Transcription initiation protein SPT3 homolog;Transcriptional adapter 3;TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L;STAGA complex 65 subunit gamma;Transcription initiation factor TFIID subunit 10;Ataxin-7-like protein 3;Transcription initiation factor TFIID subunit 12;Transcription initiation factor TFIID subunit 9;Transcriptional adapter 2-beta;Transcription factor SPT20 homolog;Histone acetyltransferase KAT2A;Transcriptional adapter 1;SAGA-associated factor 29;Histone deacetylase complex subunit SAP130;Transcription and mRNA export factor ENY2;Ubiquitin carboxyl-terminal hydrolase 22;Transformation/transcription domain-associated protein;TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L	ATXN7;SUPT3H;TADA3;TAF5L;SUPT7L;TAF10;ATXN7L3;TAF12;TAF9;TADA2B;SUPT20H;KAT2A;TADA1;SGF29;SAP130;ENY2;USP22;TRRAP;TAF6L	SCA7;SPT3;ADA3 TADA3L;PAF65B;KIAA0764;TAF2A TAF2H TAFII30;None;TAF15 TAF2J TAFII20;TAF2G TAFII31;ADA2B;C13orf19 FAM48A;GCN5 GCN5L2;TADA1L;CCDC101;None;None;KIAA1063,USP3L;PAF400;PAF65A
6665	ATAC complex, YEATS2-linked	Human	HAT complex ATAC; Histone acetyltransferase complex ATAC	HeLa S3 cells; HEK293 cells	O43318;O75478;O75528;P61964;Q01658;Q14157;Q8IYH5;Q92830;Q96ES7;Q9H8E8;Q9NR33;Q9NRF9;Q9NS73;Q9ULM3	6885;6871;10474;11091;1810;9898;26009;2648;112869;57325;56655;54107;51562;55689	MI:0007-anti tag coimmunoprecipitation;MI:0096-pull down	GO:0005634;GO:0016573	nucleus;histone acetylation	70.10	nucleus	18838386	None	None	The authors indicate that the interaction of UBAP2L to ATAC complex is only weak, but is observed under physiological salt concentrations.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mitogen-activated protein kinase kinase kinase 7;Transcriptional adapter 2-alpha;Transcriptional adapter 3;WD repeat-containing protein 5;Protein Dr1;Ubiquitin-associated protein 2-like;ZZ-type zinc finger-containing protein 3;Histone acetyltransferase KAT2A;SAGA-associated factor 29;Cysteine-rich protein 2-binding protein;DNA polymerase epsilon subunit 4;DNA polymerase epsilon subunit 3;MAP3K12-binding inhibitory protein 1;YEATS domain-containing protein 2	MAP3K7;TADA2A;TADA3;WDR5;DR1;UBAP2L;ZZZ3;KAT2A;SGF29;KAT14;POLE4;POLE3;MBIP;YEATS2	TAK1;TADA2L;ADA3 TADA3L;BIG3;None;KIAA0144 NICE4;None;GCN5 GCN5L2;CCDC101;CSRP2BP;None;CHRAC17;None;KIAA1197
6668	GLIS3-SUFU complex	Human	None	HEK293 cells	Q8NEA6;Q9UMX1	169792;51684	MI:0019-coimmunoprecipitation	GO:0006351;GO:0005634	DNA-templated transcription;nucleus	11;70.10	TRANSCRIPTION;nucleus	21543335	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Zinc finger protein GLIS3;Suppressor of fused homolog	GLIS3;SUFU	ZNF515;None
6671	PI4K2A-WASH complex	Human	None	SHSY-5Y neuroblastoma cells	O00203;P46934;P47756;P50570;P52907;Q00610;Q12768;Q2M389;Q5T1M5;Q641Q2;Q92888;Q92974;Q96N67;Q9BTU6	8546;4734;832;1785;829;1213;9897;23325;23307;387680;9138;9181;85440;55361	MI:0019-coimmunoprecipitation;MI:0069-mass spectrometry studies of complexes;MI:0096-pull down	GO:0005769;GO:0071203	early endosome;WASH complex	None	None	23676666	Two complexes, the WASH complex (an endosomal Arp2/3 activator) and the biogenesis of lysosome-related organelles complex-1 (BLOC-1), interact with and are regulated by the lipid kinase phosphatidylinositol-4-kinase type IIalpha (PI4K2A). (Novel) regulators of these complexes that copurify with PI4K2A are additionally displayed.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	AP-3 complex subunit beta-1;E3 ubiquitin-protein ligase NEDD4;F-actin-capping protein subunit beta;Dynamin-2;F-actin-capping protein subunit alpha-1;Clathrin heavy chain 1;WASH complex subunit 5;WASH complex subunit 4;FK506-binding protein 15;WASH complex subunit 2A;Rho guanine nucleotide exchange factor 1;Rho guanine nucleotide exchange factor 2;Dedicator of cytokinesis protein 7;Phosphatidylinositol 4-kinase type 2-alpha	AP3B1;NEDD4;CAPZB;DNM2;CAPZA1;CLTC;WASHC5;WASHC4;FKBP15;WASHC2A;ARHGEF1;ARHGEF2;DOCK7;PI4K2A	ADTB3A;KIAA0093 NEDD4-1 RPF1;None;DYN2;None;CLH17 CLTCL2 KIAA0034;KIAA0196;KIAA1033;KIAA0674;FAM21A FAM21B;None;KIAA0651 LFP40;KIAA1771;None
6675	PI4K2A-PRDX1 complex	Human	None	SHSY-5Y neuroblastoma cells	Q06830;Q9BTU6	5052;55361	MI:0069-mass spectrometry studies of complexes;MI:0096-pull down	GO:0016209;GO:0052742	antioxidant activity;phosphatidylinositol kinase activity	None	None	23676666	Two complexes, the WASH complex (an endosomal Arp2/3 activator) and the biogenesis of lysosome-related organelles complex-1 (BLOC-1), interact with and are regulated by the lipid kinase phosphatidylinositol-4-kinase type II alpha (PI4K2A). It was also found that PI4KIIA interacts with the antioxidant enzyme peroxiredoxin-1 (Prdx-1).	None	None	Homo sapiens (Human);Homo sapiens (Human)	Peroxiredoxin-1;Phosphatidylinositol 4-kinase type 2-alpha	PRDX1;PI4K2A	PAGA PAGB TDPX2;None
6676	WWTR1-YWHAQ complex	Human	TAZ-14-3-3 complex	HEK293T cells	P27348;Q9GZV5	10971;25937	MI:0019-coimmunoprecipitation	GO:0035329;GO:0006351	hippo signaling;DNA-templated transcription	11	TRANSCRIPTION	21555462	None	None	The authors did not mention which 14-3-3 protein was used.	Homo sapiens (Human);Homo sapiens (Human)	14-3-3 protein theta;WW domain-containing transcription regulator protein 1	YWHAQ;WWTR1	None;TAZ
6680	CTNNB1-GLIS2 complex	Human	None	HCT116 cells	P35222;Q9BZE0	1499;84662	MI:0019-coimmunoprecipitation	GO:0060070	canonical Wnt signaling pathway	None	None	17289029	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Catenin beta-1;Zinc finger protein GLIS2	CTNNB1;GLIS2	CTNNB;NKL
6681	DVL2-INVS-NPHP4-RPGRIP1L complex	Human	None	HEK293T cells	O14641;O75161;Q68CZ1;Q9Y283	1856;261734;23322;27130	MI:0019-coimmunoprecipitation	GO:0001736;GO:0097546;GO:0060271	establishment of planar polarity;ciliary base;cilium assembly	None	None	22927466	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Segment polarity protein dishevelled homolog DVL-2;Nephrocystin-4;Protein fantom;Inversin	DVL2;NPHP4;RPGRIP1L;INVS	None;KIAA0673;FTM KIAA1005 NPHP8;INV NPHP2
6682	MKS1-TMEM67 complex	Human	None	HEK293 cells	Q5HYA8;Q9NXB0	91147;54903	MI:0019-coimmunoprecipitation	GO:0060271	cilium assembly	None	None	17185389	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Meckelin;Tectonic-like complex member MKS1	TMEM67;MKS1	MKS3;None
6683	SYNE2-TMEM67 complex	Human	None	HEK 293 cells	Q5HYA8;Q8WXH0	91147;23224	MI:0019-coimmunoprecipitation	GO:0060271;GO:0031532	cilium assembly;actin cytoskeleton reorganization	None	None	19596800	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Meckelin;Nesprin-2	TMEM67;SYNE2	MKS3;KIAA1011,NUA
6684	TNFR2 signaling complex	Human	TNF-TNFRSF1B-XPNPEP3m complex; TNF-TNFR2-APP3m complex	HEK293T cells	P01375;P20333;Q9NQH7-1	7124;7133;None	MI:0019-coimmunoprecipitation	GO:0002947;GO:0033209	tumor necrosis factor receptor superfamily complex;tumor necrosis factor-mediated signaling pathway	None	None	25609706	None	None	The mitochondrial 57 kDa isoform of XPNPEP3 (APP3m), but not cytosolic APP3 (APP3c), was found in the complex.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Tumor necrosis factor;Tumor necrosis factor receptor superfamily member 1B;Isoform 1 of Xaa-Pro aminopeptidase 3	TNF;TNFRSF1B;XPNPEP3	TNFA TNFSF2;TNFBR, TNFR2;None
6685	IL13RA1-TRAF3IP1 complex	Human	IL-13Ralpha1 - MIP-T3 complex	293T cells	P78552;Q8TDR0	3597;26146	MI:0019-coimmunoprecipitation	GO:0019973;GO:0007165	interleukin-13 binding;signal transduction	30	CELLULAR COMMUNICATION/SIGNAL TRANSDUCTION MECHANISM	12935900	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Interleukin-13 receptor subunit alpha-1;TRAF3-interacting protein 1	IL13RA1;TRAF3IP1	IL13R, IL13RA;IFT54 MIPT3
6688	GLIS2-TRIM32 complex	Human	None	HEK 293T cells	Q13049;Q9BZE0	22954;84662	MI:0019-coimmunoprecipitation	GO:0005634;GO:0006351	nucleus;DNA-templated transcription	70.10;11	nucleus;TRANSCRIPTION	24500717	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase TRIM32;Zinc finger protein GLIS2	TRIM32;GLIS2	HT2A;NKL
6689	DTNBP1-TRIM32 complex	Human	None	HEK293T cells	Q13049;Q96EV8	22954;84062	MI:0019-coimmunoprecipitation	GO:0016567	protein ubiquitination	14.07.05	modification by ubiquitination, deubiquitination	19349376	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase TRIM32;Dysbindin	TRIM32;DTNBP1	HT2A;BLOC1S8
6690	NEDD4-PI4K2A complex	Human	None	SHSY-5Y neuroblastoma cells	P46934;Q9BTU6	4734;55361	MI:0019-coimmunoprecipitation;MI:0069-mass spectrometry studies of complexes;MI:0096-pull down	GO:0052742;GO:0031625	phosphatidylinositol kinase activity;ubiquitin protein ligase binding	None	None	23676666	Two complexes, the WASH complex (an endosomal Arp2/3 activator) and the biogenesis of lysosome-related organelles complex-1 (BLOC-1), interact with and are regulated by the lipid kinase phosphatidylinositol-4-kinase type II alpha (PI4K2A). It was also found that PI4KIIA interacts with the ubiquitin ligase Nedd4-1.	None	None	Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase NEDD4;Phosphatidylinositol 4-kinase type 2-alpha	NEDD4;PI4K2A	KIAA0093 NEDD4-1 RPF1;None
6691	CLTC-PI4K2A complex	Human	CHC-PIK42A complex	SHSY-5Y neuroblastoma cells	Q00610;Q9BTU6	1213;55361	MI:0019-coimmunoprecipitation;MI:0069-mass spectrometry studies of complexes;MI:0096-pull down	GO:0030133;GO:0052742;GO:0030276	transport vesicle;phosphatidylinositol kinase activity;clathrin binding	70.09	intracellular transport vesicles	23676666	Two complexes, the WASH complex (an endosomal Arp2/3 activator) and the biogenesis of lysosome-related organelles complex-1 (BLOC-1), interact with and are regulated by the lipid kinase phosphatidylinositol-4-kinase type IIalpha (PI4K2A). It was also found that PI4KIIA interacts with vesicle-mediated transport proteins such as clathrin heavy chain.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Clathrin heavy chain 1;Phosphatidylinositol 4-kinase type 2-alpha	CLTC;PI4K2A	CLH17 CLTCL2 KIAA0034;None
6692	BLOC1S6-PI4K2A complex	Human	PI4K2A-PLDN complex	SHSY-5Y neuroblastoma cells	Q9BTU6;Q9UL45	55361;26258	MI:0019-coimmunoprecipitation;MI:0069-mass spectrometry studies of complexes;MI:0096-pull down	GO:0052742;GO:0031082	phosphatidylinositol kinase activity;BLOC complex	None	None	23676666	Two complexes, the WASH complex (an endosomal Arp2/3 activator) and the biogenesis of lysosome-related organelles complex-1 (BLOC-1), interact with and are regulated by the lipid kinase phosphatidylinositol-4-kinase type IIalpha (PI4K2A). It was also found that PI4KIIA interacts with the pallidin subunit of BLOC-1.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Phosphatidylinositol 4-kinase type 2-alpha;Biogenesis of lysosome-related organelles complex 1 subunit 6	PI4K2A;BLOC1S6	None;PA, PLDN
6693	DVL1-PI4K2A complex	Human	Dsh-PI4K2A complex	HEK293T cells	O14640;Q9BTU6	1855;55361	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0052742	phosphatidylinositol kinase activity	None	None	19561074	Dvl directly interacts with and activates PI4KII alpha by increasing its V(max) for ATP and PtdIns.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Segment polarity protein dishevelled homolog DVL-1;Phosphatidylinositol 4-kinase type 2-alpha	DVL1;PI4K2A	None;None
6695	MKKS-BBS12 complex	Human	BBS6-BBS12 complex	HEK 293T cells	Q6ZW61;Q9NPJ1	166379;8195	MI:0019-coimmunoprecipitation	GO:0005929;GO:0060271	cilium;cilium assembly	None	None	26900326	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Bardet-Biedl syndrome 12 protein;Molecular chaperone MKKS	BBS12;MKKS	C4orf24;BBS6
6699	KCNQ1 homotetramer	Human	Kv1.7 homotetramer	None	P51787	3784	MI:0051-fluorescence technology	GO:0071805;GO:0005249;GO:0008076	potassium ion transmembrane transport;voltage-gated potassium channel activity;voltage-gated potassium channel complex	None	None	20962273	None	None	None	Homo sapiens (Human)	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	KCNA8 KCNA9 KVLQT1
6701	DVL1-PIP5K1B-PI4K2A complex	Human	Dsh-PIP5K1B-PI4K2A complex	HEK293T cells	O14640;O14986;Q9BTU6	1855;8395;55361	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0052742	phosphatidylinositol kinase activity	None	None	19561074	In a coimmunoprecipitation experiment PI4K2A, PIP5K1B proteins were pulled down with Dvl in HEK293T cells. Wnt promotes the formation of this Dvl, PI4K2A, and PIP5K1B  complex as Wnt3a is able to induce the binding of Dvl to the PIP5K1B and PI4K2A complex, leading to a more stable interaction between PIP5K1B and PI4K2A.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Segment polarity protein dishevelled homolog DVL-1;Phosphatidylinositol 4-phosphate 5-kinase type-1 beta;Phosphatidylinositol 4-kinase type 2-alpha	DVL1;PIP5K1B;PI4K2A	None;STM7;None
6702	CXCR2-NHERF1-PLC-beta-3 complex	Human	CXCR2-SLC9A3R1-PLCB3 complex	normal human pancreatic duct epithelial (HPDE) cells, Colo357; pancreatic ductal adenocarcinoma (PDA	O14745;P25025;Q01970	9368;3579;5331	MI:0019-coimmunoprecipitation	GO:0008283;GO:0070098	cell population proliferation;chemokine-mediated signaling pathway	None	None	23544174	The authors observed significantly reduced cell proliferation in Colo357 and HPAC cells, stimulated by CXCL5 and CXCL8.	Disrupting the CXCR2 complex significantly inhibited the malignant cellular functions (i.e., proliferation and invasion) in vitro and pancreatic tumor growth in vivo.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Na(+)/H(+) exchange regulatory cofactor NHE-RF1;C-X-C chemokine receptor type 2;1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	SLC9A3R1;CXCR2;PLCB3	NHERF NHERF1;IL8RB;None
6703	TBCD-tubulin(alpha)-tubulin(beta) complex	Human	None	HEK293T cells	P07437;Q71U36;Q9BTW9	203068;7846;6904	MI:0071-molecular sieving;MI:0276-blue native page	GO:0000226	microtubule cytoskeleton organization	42.04.05	microtubule cytoskeleton	28126905	None	None	Since the authors did not specify tubulin-alpha and tubulin-beta, we used Tubulin alpha-1A chain (Q71U36) and Tubulin beta chain (P07437).	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Tubulin beta chain;Tubulin alpha-1A chain;Tubulin-specific chaperone D	TUBB;TUBA1A;TBCD	TUBB5;TUBA3;KIAA0988 SSD1 TFCD
6704	KCNQ1-KCNE2 complex	Human	Kv7.1-KCNE2 complex	COS cells	P51787;Q9Y6J6	3784;9992	MI:0019-coimmunoprecipitation	GO:0071805;GO:0005249;GO:0008076;GO:0071805	potassium ion transmembrane transport;voltage-gated potassium channel activity;voltage-gated potassium channel complex;potassium ion transmembrane transport	None	None	11101505	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Potassium voltage-gated channel subfamily KQT member 1;Potassium voltage-gated channel subfamily E member 2	KCNQ1;KCNE2	KCNA8 KCNA9 KVLQT1;None
6705	KCNQ1-KCNE3 complex	Human	Kv7.1-KCNE3 complex	intestinal and tracheal epithelia,	P51787;Q9Y6H6	3784;10008	MI:0013-biophysical	GO:0034765;GO:0005249;GO:0008076;GO:0071805	regulation of ion transmembrane transport;voltage-gated potassium channel activity;voltage-gated potassium channel complex;potassium ion transmembrane transport	None	None	27626070	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Potassium voltage-gated channel subfamily KQT member 1;Potassium voltage-gated channel subfamily E member 3	KCNQ1;KCNE3	KCNA8 KCNA9 KVLQT1;None
6706	CAPN1-HSP90AB1 complex	Human	None	human leukemic T cell JA3 cells	P07384;P08238	823;3326	MI:0019-coimmunoprecipitation	GO:0006508	proteolysis	None	None	25575026	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Calpain-1 catalytic subunit;Heat shock protein HSP 90-beta	CAPN1;HSP90AB1	CANPL1;HSP90B HSPC2 HSPCB
6707	PIP5K1B-PI4K2A complex	Human	PIP5KI-PI4KII complex	HEK293 cells	O14986;Q9BTU6	8395;55361	MI:0019-coimmunoprecipitation	GO:0052742	phosphatidylinositol kinase activity	None	None	19561074	Wnt3a is able to induce the binding of Dvl to the PIP5K1B and PI4K2A complex, leading to a more stable interaction between PIP5K1B and PI4K2A.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Phosphatidylinositol 4-phosphate 5-kinase type-1 beta;Phosphatidylinositol 4-kinase type 2-alpha	PIP5K1B;PI4K2A	STM7;None
6708	KCNQ1-KCNE4 complex	Human	Kv7.1-KCNE5 complex	HEK293 cells	P51787;Q8WWG9	3784;23704	MI:0028-cosedimentation in solution;MI:0051-fluorescence technology	GO:0071805;GO:0005249;GO:0008076	potassium ion transmembrane transport;voltage-gated potassium channel activity;voltage-gated potassium channel complex	None	None	20533308	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Potassium voltage-gated channel subfamily KQT member 1;Potassium voltage-gated channel subfamily E member 4	KCNQ1;KCNE4	KCNA8 KCNA9 KVLQT1;None
6709	KCNQ1-KCNE5 complex	Human	Kv7.1-KCNE5 complex	HEK293 cells	P51787;Q9UJ90	3784;23630	MI:0028-cosedimentation in solution;MI:0051-fluorescence technology	GO:0071805;GO:0005249;GO:0000087;GO:0008076	potassium ion transmembrane transport;voltage-gated potassium channel activity;mitotic M phase;voltage-gated potassium channel complex	None	None	20533308	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Potassium voltage-gated channel subfamily KQT member 1;Potassium voltage-gated channel subfamily E regulatory beta subunit 5	KCNQ1;KCNE5	KCNA8 KCNA9 KVLQT1;AMMECR2 KCNE1L
6710	Calpain 1	Human	mu-Calpain	erythrocytes	P04632;P07384	826;823	MI:0019-coimmunoprecipitation	GO:0006508	proteolysis	None	None	8886026	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Calpain small subunit 1;Calpain-1 catalytic subunit	CAPNS1;CAPN1	CAPN4 CAPNS;CANPL1
6712	KCNQ2-KCNQ3 complex	Human	Kv7.2-Kv3.3 complex	brain	O43525;O43526	3786;3785	MI:0019-coimmunoprecipitation	GO:0071805;GO:0005249;GO:0008076	potassium ion transmembrane transport;voltage-gated potassium channel activity;voltage-gated potassium channel complex	None	None	10781098	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Potassium voltage-gated channel subfamily KQT member 3;Potassium voltage-gated channel subfamily KQT member 2	KCNQ3;KCNQ2	None;None
6713	TBCD-ARL2-tubulin(beta) complex	Human	None	HEK293T cells	P07437;P36404;Q9BTW9	203068;402;6904	MI:0071-molecular sieving;MI:0276-blue native page	GO:0000226;GO:0046785	microtubule cytoskeleton organization;microtubule polymerization	42.04.05	microtubule cytoskeleton	28126905	None	None	The authors state that it was impossible to specify the isoform of tubulin-beta. We used Tubulin beta chain (P07437).	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Tubulin beta chain;ADP-ribosylation factor-like protein 2;Tubulin-specific chaperone D	TUBB;ARL2;TBCD	TUBB5;None;KIAA0988 SSD1 TFCD
6714	TBCE-TBCB-tubulin(alpha) complex	Human	None	HEK293T cells	Q15813;Q71U36;Q99426	6905;7846;1155	MI:0071-molecular sieving	GO:0000226	microtubule cytoskeleton organization	42.04.05	microtubule cytoskeleton	28126905	None	None	Since the authors did not specify tubulin-alpha, we used Tubulin alpha-1A chain (Q71U36).	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Tubulin-specific chaperone E;Tubulin alpha-1A chain;Tubulin-folding cofactor B	TBCE;TUBA1A;TBCB	None;TUBA3;CG22 CKAP1
6715	TBCD-ARL2-tubulin(beta)-TBCE complex	Human	None	HEK293T cells	P07437;P36404;Q15813;Q9BTW9	203068;402;6905;6904	MI:0019-coimmunoprecipitation	GO:0000226	microtubule cytoskeleton organization	42.04.05	microtubule cytoskeleton	28126905	None	None	Since the authors did not specify tubulin-beta, we used Tubulin beta chain (P07437).	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Tubulin beta chain;ADP-ribosylation factor-like protein 2;Tubulin-specific chaperone E;Tubulin-specific chaperone D	TUBB;ARL2;TBCE;TBCD	TUBB5;None;None;KIAA0988 SSD1 TFCD
6716	DLG5-MST1-MST2 complex	Human	None	HEK293T cells	Q13043;Q13188;Q8TDM6	6789;6788;9231	MI:0019-coimmunoprecipitation	GO:0030010;GO:0035330	establishment of cell polarity;regulation of hippo signaling	None	None	28087714	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein kinase 4;Serine/threonine-protein kinase 3;Disks large homolog 5	STK4;STK3;DLG5	KRS2, MST1;KRS1, MST2;KIAA0583 PDLG
6717	KCNQ3-KCNQ5 complex	Human	Kv7.3-Kv7,5 complex	brain	O43525;Q9NR82	3786;56479	MI:0019-coimmunoprecipitation	GO:0071805;GO:0005249;GO:0007268;GO:0071805	potassium ion transmembrane transport;voltage-gated potassium channel activity;chemical synaptic transmission;potassium ion transmembrane transport	34.03.01	synaptic transmission	12890507	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Potassium voltage-gated channel subfamily KQT member 3;Potassium voltage-gated channel subfamily KQT member 5	KCNQ3;KCNQ5	None;None
6718	CALM1-KCNQ4(splice variant hKv7.4a) complex	Human	CaM-Kv7.4(splice variant 1) complex	None	P0DP23;P56696-1	801;9132	MI:0019-coimmunoprecipitation	GO:0043266	regulation of potassium ion transport	None	None	26515070	CaM binds to two isoforms (P56696-1 long and P56696-2 short) of the hKv7.4 channel in a Ca(2+)-independent manner but that only the long isoform (hKv7.4a) is regulated by Ca(2+)/CaM.	None	P62158 is obsolete. On May 10, 2017 this ID became obsolete. It can now be found as secondary accession in P0DP23, P0DP24 and P0DP25.	Homo sapiens (Human);Homo sapiens (Human)	Calmodulin-1;Isoform 1 of Potassium voltage-gated channel subfamily KQT member 4	CALM1;KCNQ4	CALM CAM CAM1;None
6719	CALM1-KCNQ4(splice variant hKv7.4b) complex	Human	CaM-Kv4.1(splice variant 2) complex	None	P0DP23;P56696-2	801;9132	MI:0019-coimmunoprecipitation	GO:0043266	regulation of potassium ion transport	None	None	26515070	CaM binds to two isoforms (P56696-1 long and P56696-2 short) of the hKv7.4 channel in a Ca(2+)-independent manner but that only the long isoform (hKv7.4a) is regulated by Ca(2+)/CaM.	None	P62158 is obsolete. On May 10, 2017 this ID became obsolete. It can now be found as secondary accession in P0DP23, P0DP24 and P0DP25.	Homo sapiens (Human);Homo sapiens (Human)	Calmodulin-1;Isoform 2 of Potassium voltage-gated channel subfamily KQT member 4	CALM1;KCNQ4	CALM CAM CAM1;None
6720	FILIP1-FLNA complex	Human	None	HEK293T cells	P21333;Q7Z7B0	2316;27145	MI:0096-pull down	GO:0031005	filamin binding	None	None	23087206	FILIP1 is a RhoD/Rif effector and an FLNa-binding protein.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Filamin-A;Filamin-A-interacting protein 1	FLNA;FILIP1	FLN, FLN1;KIAA1275
6722	FILIP1-RHOD complex	Human	None	HEK293T cells	O00212;Q7Z7B0	29984;27145	MI:0096-pull down	GO:0046847;GO:0051017	filopodium assembly;actin filament bundle assembly	None	None	23087206	RhoD induces the formation of filopodia and actin bundles and binds FILIP1 in a GTP-dependent manner.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Rho-related GTP-binding protein RhoD;Filamin-A-interacting protein 1	RHOD;FILIP1	ARHD;KIAA1275
6724	RHOD-WHAMM complex	Human	None	HEK293T cells	O00212;Q8TF30	29984;123720	MI:0096-pull down	GO:0031532	actin cytoskeleton reorganization	None	None	23087206	WHAMM is required for RhoD-dependent actin reorganization. RhoD binds WHAMM in a GTP-dependent manner.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Rho-related GTP-binding protein RhoD;WASP homolog-associated protein with actin, membranes and microtubules	RHOD;WHAMM	ARHD;KIAA1971 WHDC1
6725	ARP3-WHAMM complex	Human	None	HEK293T cell	P61158;Q8TF30	10096;123720	MI:0019-coimmunoprecipitation	GO:0031532	actin cytoskeleton reorganization	None	None	23087206	WHAMM is required for RhoD-dependent actin reorganization and binds to the Arp2/3 complex. The presence of the Arp2/3 complex in the immunoprecipitates was revealed using antibodies against Arp3A.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Actin-related protein 3;WASP homolog-associated protein with actin, membranes and microtubules	ACTR3;WHAMM	ARP3;KIAA1971 WHDC1
6726	GRASP1-GRIP1 complex	Human	None	HEK293 cells	Q4V328;Q9Y3R0	56850;23426	MI:0019-coimmunoprecipitation	GO:0005085	guanyl-nucleotide exchange factor activity	18.02.03	guanyl-nucleotide exchange factor (GEF)	10896157	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	GRIP1-associated protein 1;Glutamate receptor-interacting protein 1	GRIPAP1;GRIP1	KIAA1167;None
6728	9-1-1-RHINO complex	Human	RHINO-Rad9-Hus1-Rad1 complex	HEK293 Flp-In T-REx cells; transfected Sf21 cells	O60671;O60921;Q99638;Q9BSD3	5810;3364;5883;83695	MI:0007-anti tag coimmunoprecipitation	GO:0000077;GO:0006281;GO:0000785;GO:0005634	DNA damage checkpoint signaling;DNA repair;chromatin;nucleus	10.01.05.01;70.10	DNA repair;nucleus	25602520	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cell cycle checkpoint protein RAD1;Checkpoint protein HUS1;Cell cycle checkpoint control protein RAD9A;RAD9, HUS1, RAD1-interacting nuclear orphan protein 1	RAD1;HUS1;RAD9A;RHNO1	REC1;None;None;C12orf32 RHINO
6729	IQGAP1-CXCR2 complex	Human	None	differentiated HL-60 cells, overexpressing CXCR2	P25025;P46940	3579;8826	MI:0006-anti bait coimmunoprecipitation	GO:0070098	chemokine-mediated signaling pathway	None	None	21876773	The signaling scaffolding protein IQGAP1 was consistently identified with both the unstimulated and activated receptor immunoprecipitations. CXCR2 colocalizes with IQGAP1 at the leading edge of polarized human neutrophils.	None	None	Homo sapiens (Human);Homo sapiens (Human)	C-X-C chemokine receptor type 2;Ras GTPase-activating-like protein IQGAP1	CXCR2;IQGAP1	IL8RB;KIAA0051
6730	14-3-3 gamma-CXCR2 complex, unstimulated	Human	YWHAG-CXCR2 complex, unstimulated	differentiated HL-60 cells, overexpressing CXCR2	P25025;P61981	3579;7532	MI:0006-anti bait coimmunoprecipitation	None	None	None	None	21876773	The interaction of CXCR2 with 14-3-3 gamma represents a potential novel link to signaling pathways through its function as an adaptor molecule that is a known regulator of G-protein signaling (RGS) proteins.	None	None	Homo sapiens (Human);Homo sapiens (Human)	C-X-C chemokine receptor type 2;14-3-3 protein gamma	CXCR2;YWHAG	IL8RB;None
6731	VASP-CXCR2 complex, CXCL8 stimulated	Human	None	differentiated HL-60 cells, overexpressing CXCR2	P25025;P50552	3579;7408	MI:0019-coimmunoprecipitation	GO:0030036	actin cytoskeleton organization	42.04.03	actin cytoskeleton	21876773	The actin regulating protein VASP may provide a link betweenthe activated chemokine receptor and the acting cytoskeleton.	None	None	Homo sapiens (Human);Homo sapiens (Human)	C-X-C chemokine receptor type 2;Vasodilator-stimulated phosphoprotein	CXCR2;VASP	IL8RB;None
6732	RHINO-TopBP1 complex	Human	None	HEK293 Flp-In T-REx cells; transfected Sf21 cells	Q92547;Q9BSD3	11073;83695	MI:0007-anti tag coimmunoprecipitation	GO:0006281;GO:0000077;GO:0000785;GO:0005634	DNA repair;DNA damage checkpoint signaling;chromatin;nucleus	10.01.05.01;70.10	DNA repair;nucleus	25602520	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	DNA topoisomerase 2-binding protein 1;RAD9, HUS1, RAD1-interacting nuclear orphan protein 1	TOPBP1;RHNO1	KIAA0259;C12orf32 RHINO
6733	9b-1-1 complex	Human	RAD9B-HUS1-RAD1 complex	K562 cells	O60671;O60921;Q6WBX8	5810;3364;144715	MI:0007-anti tag coimmunoprecipitation	GO:0006281;GO:0000077;GO:0005634	DNA repair;DNA damage checkpoint signaling;nucleus	10.01.05.01;70.10	DNA repair;nucleus	14611806	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cell cycle checkpoint protein RAD1;Checkpoint protein HUS1;Cell cycle checkpoint control protein RAD9B	RAD1;HUS1;RAD9B	REC1;None;None
6734	9b-1b-1 complex	Human	RAD9B-HUS1B-RAD1 complex	K562 cells	O60671;Q6WBX8;Q8NHY5	5810;144715;135458	MI:0007-anti tag coimmunoprecipitation	GO:0005634;GO:0000077;GO:0006281	nucleus;DNA damage checkpoint signaling;DNA repair	70.10;10.01.05.01	nucleus;DNA repair	14611806	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cell cycle checkpoint protein RAD1;Cell cycle checkpoint control protein RAD9B;Checkpoint protein HUS1B	RAD1;RAD9B;HUS1B	REC1;None;None
6735	SIGMAR1-KCNH2 complex	Human	sigma-1 receptor-hERG complex	HEK-293 cells	Q12809;Q99720	3757;10280	MI:0051-fluorescence technology	GO:1901379	regulation of potassium ion transmembrane transport	None	None	25266722	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Potassium voltage-gated channel subfamily H member 2;Sigma non-opioid intracellular receptor 1	KCNH2;SIGMAR1	ERG ERG1 HERG;OPRS1 SRBP
6736	PRAME-Cullin2 ubiquitin ligase complex	Human	None	K562 cells	P78395;Q13617	23532;8453	MI:0007-anti tag coimmunoprecipitation	GO:0005634;GO:0003682;GO:0016567	nucleus;chromatin binding;protein ubiquitination	70.10;14.07.05	nucleus;modification by ubiquitination, deubiquitination	21822215	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Melanoma antigen preferentially expressed in tumors;Cullin-2	PRAME;CUL2	MAPE OIP4;None
6737	H2A-H2B-TDIF2-PCNA complex	Human	None	None	P12004;Q16777;Q16778;Q5QJE6	5111;8338;8349;30836	MI:0019-coimmunoprecipitation	GO:0006338;GO:0005634;GO:0003677	chromatin remodeling;nucleus;DNA binding	70.10;16.03.01	nucleus;DNA binding	12786946	TdIF2 takes H2A/H2B away from the core histone in the presence of PCNA to form aH2A-H2B-TdIF2-PCNA complex, indicating that TdIF2 functions as a chromatin remodeling protein.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Proliferating cell nuclear antigen;Histone H2A type 2-C;Histone H2B type 2-E;Deoxynucleotidyltransferase terminal-interacting protein 2	PCNA;H2AC20;H2BC21;DNTTIP2	None;H2AFQ HIST2H2AC;H2BFQ HIST2H2BE;ERBP, TDIF2
6738	PRAME-ElonginBC ubiquitin ligase	Human	None	K562 cells	P78395;Q15369;Q15370	23532;6921;6923	MI:0007-anti tag coimmunoprecipitation	GO:0003682;GO:0005634;GO:0016567	chromatin binding;nucleus;protein ubiquitination	70.10;14.07.05	nucleus;modification by ubiquitination, deubiquitination	21822215	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Melanoma antigen preferentially expressed in tumors;Elongin-C;Elongin-B	PRAME;ELOC;ELOB	MAPE OIP4;TCEB1;TCEB2
6740	AURKA-INPP5E complex	Human	None	HEK293 cells	O14965;Q9NRR6	6790;56623	MI:0019-coimmunoprecipitation	GO:0005929;GO:0048015;GO:0061523	cilium;phosphatidylinositol-mediated signaling;cilium disassembly	None	None	25395580	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Aurora kinase A;Phosphatidylinositol polyphosphate 5-phosphatase type IV	AURKA;INPP5E	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6;None
6741	INPP5E-PDE6D-RPGR complex	Human	None	HEK293T cells	O43924;Q92834;Q9NRR6	5147;6103;56623	MI:0676-tandem affinity purification	GO:0061512;GO:0044782;GO:0006886	protein localization to cilium;cilium organization;intracellular protein transport	14.04	protein targeting, sorting and translocation	28172980	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta;X-linked retinitis pigmentosa GTPase regulator;Phosphatidylinositol polyphosphate 5-phosphatase type IV	PDE6D;RPGR;INPP5E	PDED;RP3 XLRP3;None
6742	SMG1-UPF2-Y14-MAGOH-UPF3B-EIF4A3 complex	Human	None	HeLa cells	P38919;P61326;Q96Q15;Q9BZI7;Q9HAU5;Q9Y5S9	9775;4116;23049;65109;26019;9939	MI:0019-coimmunoprecipitation	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	None	None	16452507	SMG-1 associates with the known EJC components Upf2, Y14, Magoh, Upf3b, and eIF4A3 through the CD region in the absence of RNA.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Eukaryotic initiation factor 4A-III;Protein mago nashi homolog;Serine/threonine-protein kinase SMG1;Regulator of nonsense transcripts 3B;Regulator of nonsense transcripts 2;RNA-binding protein 8A	EIF4A3;MAGOH;SMG1;UPF3B;UPF2;RBM8A	DDX48, KIAA0111;MAGOHA;ATX KIAA0421 LIP;RENT3B, UPF3X;KIAA1408, RENT2;RBM8
6743	AHI1-NPHP1 heterodimer	Human	None	HEK293 cells	O15259;Q8N157	4867;54806	MI:0019-coimmunoprecipitation	GO:0060271	cilium assembly	None	None	23532844	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Nephrocystin-1;Jouberin	NPHP1;AHI1	NPH1;None
6744	AHI1-HAP1 complex	Human	None	HEK293T cells	P54257;Q8N157	9001;54806	MI:0018-two hybrid;MI:0019-coimmunoprecipitation	GO:0007420;GO:0060271	brain development;cilium assembly	47.03.01.01.01	brain	23532844	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Huntingtin-associated protein 1;Jouberin	HAP1;AHI1	HAP2, HLP1;None
6747	AQP1 homotetramer	Human	Aquaporin complex	erythrocyte	P29972	358	MI:0040-electron microscopy	GO:0006833;GO:0005372	water transport;water transmembrane transporter activity	None	None	7693713	None	None	None	Homo sapiens (Human)	Aquaporin-1	AQP1	CHIP28
6748	KCNMA1-LRRC26 complex	Human	None	HEK293 cells	Q12791;Q2I0M4	3778;389816	MI:0019-coimmunoprecipitation	None	None	None	None	20613726	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Calcium-activated potassium channel subunit alpha-1;Leucine-rich repeat-containing protein 26	KCNMA1;LRRC26	KCNMA SLO;CAPC
6750	AHI1-NPHP1 heterotetramer	Human	None	HEK293 cells	O15259;Q8N157	4867;54806	MI:0019-coimmunoprecipitation	GO:0060271	cilium assembly	None	None	23532844	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Nephrocystin-1;Jouberin	NPHP1;AHI1	NPH1;None
6753	SOG complex	Human	SZT2-orchestrated GATOR complex; SZT2\u2013GATOR1\u2013GATOR2 complex	HEK293T cells	P55735;Q12980;Q5T011;Q6PJI9;Q8WTW4;Q96EE3;Q96S15;Q9NXC5	6396;8131;23334;79726;10641;81929;84219;54468	MI:0007-anti tag coimmunoprecipitation;MI:0071-molecular sieving	GO:0032418;GO:1904262	lysosome localization;negative regulation of TORC1 signaling	None	None	28199315	The SOG complex has a molecular weight of around 1.06 MDa.	Mutations in the metazoan-specific SZT2 gene cause epilepsy, a disease frequently associated with mTORC1 hyperactivation.SZT2 deficiency results in constitutive mTORC1 signalling in cells under nutrient-deprived conditions and neonatal lethality in mice, which was associated with failure to inactivate mTORC1 during fasting.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein SEC13 homolog;GATOR complex protein NPRL3;KICSTOR complex protein SZT2;GATOR complex protein WDR59;GATOR complex protein NPRL2;Nucleoporin SEH1;GATOR complex protein WDR24;GATOR complex protein MIOS	SEC13;NPRL3;SZT2;WDR59;NPRL2;SEH1L;WDR24;MIOS	D3S1231E SEC13A SEC13L1 SEC13R;C16orf35 CGTHBA MARE;C1orf84 KIAA0467;KIAA1923;TUSC4;SEC13L SEH1;C16orf21;None
6754	KICSTOR complex	Human	None	HEK293T cells	Q5T011;Q969R8;Q96MD2;Q9Y664	23334;55846;144577;11133	MI:0007-anti tag coimmunoprecipitation;MI:0071-molecular sieving	GO:0032418;GO:1904262;GO:0010506	lysosome localization;negative regulation of TORC1 signaling;regulation of autophagy	None	None	28199306	KICSTOR localizes to lysosomes; binds andrecruits GATOR1, but not GATOR2, to the lysosomal surface; and is necessary for the interaction of GATOR1 with its substrates, the Rag GTPases, and with GATOR2.HEK293T cells that lack any of the KICSTOR subunits, amino acid deprivation did not inhibit mTORC1 signalling, or induce autophagy.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	KICSTOR complex protein SZT2;KICSTOR complex protein ITFG2;KICSTOR subunit 2;KICSTOR complex protein kaptin	SZT2;ITFG2;KICS2;KPTN	C1orf84 KIAA0467;None;C12orf66;None
6756	RasGAP-AURKB-survivin complex	Human	None	HeLa cells	O15392;P20936;Q96GD4	332;5921;9212	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0007186;GO:0000278;GO:0051726	G protein-coupled receptor signaling pathway;mitotic cell cycle;regulation of cell cycle	30.05.02.24;10.03.01.01;10.03.01	G-protein coupled receptor signalling pathway;mitotic cell cycle;mitotic cell cycle and cell cycle control	11976319	The authors define this ternary complex by several protein-protein interactions. RasGAP binds to the kinase domain of Aurora and this interaction inhibits the kinase activity of AURKA and AURKB.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Baculoviral IAP repeat-containing protein 5;Ras GTPase-activating protein 1;Aurora kinase B	BIRC5;RASA1;AURKB	API4 IAP4;GAP RASA;AIK2 AIM1 AIRK2 ARK2 STK1 STK12 STK5
6758	IL-10Ralpha/beta receptor-IL-10 complex	Human	Interleukin-10 receptor complex; IL-10 receptor; IL10RA-IL10RB receptor complex	peripheral blood mononuclear cells	P22301;Q08334;Q13651	3586;3588;3587	MI:0019-coimmunoprecipitation	GO:0050728;GO:0042100;GO:0070662;GO:0006955;GO:0019221;GO:0042110	negative regulation of inflammatory response;B cell proliferation;mast cell proliferation;immune response;cytokine-mediated signaling pathway;T cell activation	36.25.16	immune response	9312047	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Interleukin-10;Interleukin-10 receptor subunit beta;Interleukin-10 receptor subunit alpha	IL10;IL10RB;IL10RA	None;CRFB4 D21S58 D21S66;IL10R
6765	CCR4-NOT complex	Human	None	HEK293 cells grown in suspension	A5YKK6;O75175;Q92600;Q9H9A5;Q9NZN8;Q9UIV1;Q9UKZ1;Q9ULM6	23019;4849;9125;25904;4848;29883;55571;57472	MI:0676-tandem affinity purification	GO:0030014;GO:0043928;GO:0003723;GO:0006355;GO:0000289;GO:0000288	CCR4-NOT complex;exonucleolytic catabolism of deadenylated mRNA;RNA binding;regulation of DNA-templated transcription;nuclear-transcribed mRNA poly(A) tail shortening;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	16.03.03;11.02.03.04	RNA binding;transcriptional control	23232451	In eukaryotes, degradation of functional mRNAs is most often initiated by progressive shortening of their poly(A) tails. This step is predominantly regulated by the CCR4-NOT complex.	None	The additional subunit TAB182 was predominantly found in HEK293-derived adherent cells and not when the cells were grown in suspension. This indicates that TAB182 is not a stable subunit of the CCR4-NOT complex but rather interacts with it in particular conditions.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	CCR4-NOT transcription complex subunit 1;CCR4-NOT transcription complex subunit 3;CCR4-NOT transcription complex subunit 9;CCR4-NOT transcription complex subunit 10;CCR4-NOT transcription complex subunit 2;CCR4-NOT transcription complex subunit 7;CCR4-NOT transcription complex subunit 11;CCR4-NOT transcription complex subunit 6	CNOT1;CNOT3;CNOT9;CNOT10;CNOT2;CNOT7;CNOT11;CNOT6	CDC39, KIAA1007, NOT1;KIAA0691 LENG2 NOT3;RCD1 RQCD1;None;CDC36 NOT2;CAF1;C2orf29;CCR4 CCR4a KIAA1194
6768	TBX20-TBX18 repressor complex	Human	None	HEK293 cells	O95935;Q9UMR3	9096;57057	MI:0007-anti tag coimmunoprecipitation	GO:0045892	negative regulation of DNA-templated transcription	11.02.03.04.03	transcription repression	24024827	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	T-box transcription factor TBX18;T-box transcription factor TBX20	TBX18;TBX20	None;None
6769	TBX20-TLE1 repressor complex	Human	None	HEK293 cells	Q04724;Q9UMR3	7088;57057	MI:0007-anti tag coimmunoprecipitation	GO:0045892;GO:0007507	negative regulation of DNA-templated transcription;heart development	11.02.03.04.03;45.03.12.03	transcription repression;heart muscle	24024827	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Transducin-like enhancer protein 1;T-box transcription factor TBX20	TLE1;TBX20	None;None
6770	TBX20-TLE3 repressor complex	Human	None	HEK293 cells	Q04726;Q9UMR3	7090;57057	MI:0007-anti tag coimmunoprecipitation	GO:0007507;GO:0045892	heart development;negative regulation of DNA-templated transcription	45.03.12.03;11.02.03.04.03	heart muscle;transcription repression	24024827	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Transducin-like enhancer protein 3;T-box transcription factor TBX20	TLE3;TBX20	KIAA1547;None
6771	TBX20-HDAC2 repressor complex	Human	None	HEK293cells	Q92769;Q9UMR3	3066;57057	MI:0007-anti tag coimmunoprecipitation	GO:0045892	negative regulation of DNA-templated transcription	11.02.03.04.03	transcription repression	24024827	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Histone deacetylase 2;T-box transcription factor TBX20	HDAC2;TBX20	None;None
6777	SCRIB-NOS1AP-VANGL1 complex	Human	None	MDA-MB-231 breast cancer cells	O75052;Q14160;Q8TAA9	9722;23513;81839	MI:0007-anti tag coimmunoprecipitation;MI:0416-fluorescence microscopy	GO:0007163;GO:0016477;GO:0030027	establishment or maintenance of cell polarity;cell migration;lamellipodium	34.05.01	cell migration	22179838	NOS1AP colocalizes with both SCRIB and VANGL1 along cellular protrusions in metastatic breast cancer cells, but does not colocalize with either SCRIB or VANGL1 at cell junctions in normal breast cells. SCRIB, NOS1AP and VANGL1 regulate the migration of human breast cancer cells.	The data point to the relevance of NOS1AP and SCRIB protein complexes in breast cancer.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein;Protein scribble homolog;Vang-like protein 1	NOS1AP;SCRIB;VANGL1	CAPON KIAA0464;CRIB1 KIAA0147 LAP4 SCRB1 VARTUL;STB2
6778	SCRIB-GIT1-ARHGEF7-PAK1 complex	Human	None	HEK293 cells	Q13153;Q14155;Q14160;Q9Y2X7	5058;8874;23513;28964	MI:0019-coimmunoprecipitation	GO:0007163;GO:0016477	establishment or maintenance of cell polarity;cell migration	34.05.01	cell migration	22179838	SCRIB associates independently with ARHGEF\u2013PAK\u2013GIT protein complexes and with NOS1AP\u2013VANGL protein complexes.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein kinase PAK 1;Rho guanine nucleotide exchange factor 7;Protein scribble homolog;ARF GTPase-activating protein GIT1	PAK1;ARHGEF7;SCRIB;GIT1	None;COOL1 KIAA0142 P85SPR PAK3BP PIXB;CRIB1 KIAA0147 LAP4 SCRB1 VARTUL;None
6779	SCRIB-GIT1-ARHGEF7-PAK1 complex	Human	None	T47D human breast cancer cells	Q13153;Q14155;Q14160;Q9Y2X7	5058;8874;23513;28964	MI:0019-coimmunoprecipitation	GO:0016477;GO:0031252;GO:0007163	cell migration;cell leading edge;establishment or maintenance of cell polarity	34.05.01	cell migration	18716323	The data demonstrate that the HRG (heregulin b1, a growth factor triggering cell motility)-dependent migration of T47D cells is controlled by the ability of Scrib to interact with the beta-PIX-PAK complex.Scrib interacts with the beta-PIX-PAK protein complex and is required for the retention of the protein complex at the leading edge of migratory cells.	None	Since the authors did not specify PAK, we used isoform PAK1.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein kinase PAK 1;Rho guanine nucleotide exchange factor 7;Protein scribble homolog;ARF GTPase-activating protein GIT1	PAK1;ARHGEF7;SCRIB;GIT1	None;COOL1 KIAA0142 P85SPR PAK3BP PIXB;CRIB1 KIAA0147 LAP4 SCRB1 VARTUL;None
6780	RAD6A-KCMF1-UBR4 complex	Human	UBE2A-KCMF1-UBR4 complex	HEK 293 T-REx cells	P49459;Q5T4S7;Q9P0J7	7319;23352;56888	MI:0400-affinity technology	GO:1905146	lysosomal protein catabolic process	None	None	25582440	None	Two different RAD6A point mutants (R7W and R11Q) found inX-linked intellectual disability (XLID) patients specifically losethe interactions with KCMF1 and UBR4.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Ubiquitin-conjugating enzyme E2 A;E3 ubiquitin-protein ligase UBR4;E3 ubiquitin-protein ligase KCMF1	UBE2A;UBR4;KCMF1	RAD6A;KIAA0462 KIAA1307 RBAF600 ZUBR1;FIGC, ZZZ1
6782	mitochondrial permeability  transition pore (PTP) complex (PPIF-SPG7-VDAC1)	Human	PPIF-SPG7-VDAC1 complex	HEK293T cells, HeLa cells, COS7 cells	P21796;P30405;Q9UQ90	7416;10105;6687	MI:0019-coimmunoprecipitation	GO:0051882;GO:0005743;GO:0005741	mitochondrial depolarization;mitochondrial inner membrane;mitochondrial outer membrane	70.16.05;70.16.01	mitochondrial inner membrane;mitochondrial outer membrane	26387735	SPG7 is a core component of the PTP (permeability  transition pore) which not only interacts with matrix protein CypD (PPIF) but also with the OMM channel VDAC1 at OMM/IMM (outer mitochondrial membrane/inner mitochondrial membrane) contact sites. Silencing or disruption of SPG7-CypD binding prevented Ca2+ and ROS-induced mitochondrial membrane potential depolarization and cell death.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Voltage-dependent anion-selective channel protein 1;Peptidyl-prolyl cis-trans isomerase F, mitochondrial;Paraplegin	VDAC1;PPIF;SPG7	VDAC;CYP3;CAR CMAR PGN
6783	CLIC5A-EZR-PODXL complex	Human	CLIC5A-Ezrin-podocalyxin complex	renal glomeruli	O00592;P15311;Q9NZA1	5420;7430;53405	MI:0663-confocal microscopy	GO:0098846;GO:0031532	podocyte foot;actin cytoskeleton reorganization	None	None	20335315	Ezrin and podocalyxin colocalize with CLIC5A in glomeruli, and podocalyxin coimmunoprecipitates with CLIC5A from glomerular lysates.	The authors postulate that the interaction between podocalyxin and subjacentfilamentous actin, which requires ezrin, is compromised in podocytes of CLIC5A-deficient mice, leading to dysfunction under unfavorable genetic or environmental conditions.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Podocalyxin;Ezrin;Chloride intracellular channel protein 5	PODXL;EZR;CLIC5	PCLP PCLP1;VIL2;None
6784	SCHIP1-EZR-NHERF2 complex	Human	SCHIP1-EZR-SLC9A3R2 complex	cultured podocytes	P0DPB3;P15311;Q15599	29970;7430;9351	MI:0055-fluorescent resonance energy transfer;MI:0663-confocal microscopy	GO:0098846;GO:0031532	podocyte foot;actin cytoskeleton reorganization	None	None	25807495	The authors propose that Schip1 is an adaptor protein in complex with ezrin-Nherf2 that links actin cytoskeleton to the podocyte foot process plasma membrane and mediates its dynamics in response to PDGF-beta.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Schwannomin-interacting protein 1;Ezrin;Na(+)/H(+) exchange regulatory cofactor NHE-RF2	SCHIP1;EZR;SLC9A3R2	None;VIL2;NHERF2
6787	NHE3-NHERF2-ACTN4, Ca(2+) induced	Human	NHE3-E3KARP-alpha-actinin-4 complex	PS120/NHE3V/E3KARP fibroblast cells stably transfected with ACTN4	O43707;P48764;Q15599	81;6550;9351	MI:0006-anti bait coimmunoprecipitation;MI:0663-confocal microscopy	GO:0002028;GO:0006885	regulation of sodium ion transport;regulation of pH	None	None	11948184	E3KARP (NHERF2) is specifically involved in the inhibition of NHE3 activity by elevation of Ca(2+) through an interaction with ACTN4. Elevation of Ca(2+) induces NHE3 oligomerization and endocytosis of NHE3 with formation of a protein complex containing NHE3, E3KARP (NHERF2), and ACTN4.	Inhibition of Na(+)/H(+) exchange induced by elevation of Ca(2+) is involved in normal intestinal physiology and in the pathophysiology of diarrheal disease (PMID: 2873653).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Alpha-actinin-4;Sodium/hydrogen exchanger 3;Na(+)/H(+) exchange regulatory cofactor NHE-RF2	ACTN4;SLC9A3;SLC9A3R2	None;NHE3;NHERF2
6788	SLC9A3R1-ACTN4 complex	Human	NHERF1-Alpha-actinin-4 complex	HeLa cells	O14745;O43707	9368;81	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0030036	actin cytoskeleton organization	42.04.03	actin cytoskeleton	26432781	The NHERF1/a-actinin-4 interaction increased a-actinin-4 ubiquitination and decreased its expression levels, resulting in actin cytoskeleton disassembly.	The results indicate that NHERF1 may regulate tumor cell invasion and metastasis through modulation of a-actinin-4 protein expression levels.	None	Homo sapiens (Human);Homo sapiens (Human)	Na(+)/H(+) exchange regulatory cofactor NHE-RF1;Alpha-actinin-4	SLC9A3R1;ACTN4	NHERF NHERF1;None
6789	EGFR-NHERF1-PTEN complex	Human	EBP50-EGFR-PTEN complex	COS-7 cells, U-373 MG (U373) cells	O14745;P00533;P60484	9368;1956;5728	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0051898	negative regulation of protein kinase B signaling	None	None	26531778	The EBP50-EGFR-PTEN complex attenuated EGF-induced AKT signaling. The disruption of this complex led to an increase of EGF-induced AKT activation level.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Na(+)/H(+) exchange regulatory cofactor NHE-RF1;Epidermal growth factor receptor;Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	SLC9A3R1;EGFR;PTEN	NHERF NHERF1;ERBB ERBB1 HER1;MMAC1, TEP1
6790	NHERF1-PRKCZ complex	Human	EBP50-PKC Zeta complex; SLC9A3R1-PRKCZ complex	CHO cells, transfected	O14745;Q05513	9368;5590	MI:0019-coimmunoprecipitation	GO:0007249	I-kappaB kinase/NF-kappaB signaling	30.01.05.01.04	NIK-I-kappaB/NF-kappaB cascade	24196963	Inflammatory stimuli promote the formation of an EBP50-PKC-Zeta complex at the cell membrane that induces NF-kappaB signaling.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Na(+)/H(+) exchange regulatory cofactor NHE-RF1;Protein kinase C zeta type	SLC9A3R1;PRKCZ	NHERF NHERF1;PKC2
6791	NHERF1-NPT2A-EZR complex	Human	Npt2a-NHERF1-ezrin complex	OKH cells (a subclone of opossum kidney (OK)), transfected	O14745;P15311;Q06495	9368;7430;6569	MI:0007-anti tag coimmunoprecipitation	GO:0006817;GO:0071374	phosphate ion transport;cellular response to parathyroid hormone stimulus	20.01.01.07.07	phosphate transport	22628548	The NHERF1 ternary complex is required for PTH (parathyroid hormone)-sensitive Pi (phosphate) transport. Mutations in Npt2a, NHERF1, or ezrin that interfere with theformation of the ternary complex or its phosphorylation impedes the normal function and regulatory influence of PTH.	The failure to assemble and regulate the Npt2a-NHERF1-ezrin ternary complex is responsible for the loss of function of the NHERF1 mutants and defines a novel molecular mechanism of PTH (parathyroid hormone) resistance and hyperphosphaturia.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Na(+)/H(+) exchange regulatory cofactor NHE-RF1;Ezrin;Sodium-dependent phosphate transport protein 2A	SLC9A3R1;EZR;SLC34A1	NHERF NHERF1;VIL2;NPT2 SLC17A2
6793	PDZK1-NHERF1-EZR complex	Human	PDZK1-EBP50-ezrin complex	JEG3 cells, LLC-PK1 cells	O14745;P15311;Q5T2W1	9368;7430;5174	MI:0096-pull down	GO:0032528	microvillus organization	None	None	20237154	PDZK1 shuttles from the nucleus in low con?uence cells to microvilli in high con?uence cells, and this regulates the formation of the PDZK1/EBP50/ezrin complex in vivo.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Na(+)/H(+) exchange regulatory cofactor NHE-RF1;Ezrin;Na(+)/H(+) exchange regulatory cofactor NHE-RF3	SLC9A3R1;EZR;PDZK1	NHERF NHERF1;VIL2;CAP70 NHERF3 PDZD1
6794	LPAR2-TRIP6-NHERF2 complex, LPA stimulated	Human	LPAR2-TRIP6-SLC9A3R2 complex, LPA stimulated	SKOV-3 cells, HEK 293T cells, LPA1/2 double knock-out  mouse embryonic fibroblasts	Q15599;Q15654;Q9HBW0	9351;7205;9170	MI:0019-coimmunoprecipitation;MI:0416-fluorescence microscopy	GO:0043066	negative regulation of apoptotic process	40.10.02.01	anti-apoptosis	19293149	LPA2-TRIP6-NHERF2 ternary complex provides a novel ligand-dependent signal amplification mechanism that is required for LPA2-mediated full activation of antiapoptotic signaling. LPA2, TRIP6, and NHERF2 colocalize in cells as shown in LPA1/2 DKO MEFs (LPA1/2 double knock-out  mouse embryonic fibroblasts) by fluorescence microscopy.	The LPA2-mediated antiapoptotic effect was abolished only when both CXXC- and PDZ-binding motifs were disrupted, indicating that the supramolecular complexes formed via the C-terminal tail of LPA2 are required for the full antiapoptotic function of LPA2, and thus play a critical role in the chemoprotective action of LPA in can-cer cells.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Na(+)/H(+) exchange regulatory cofactor NHE-RF2;Thyroid receptor-interacting protein 6;Lysophosphatidic acid receptor 2	SLC9A3R2;TRIP6;LPAR2	NHERF2;OIP1;EDG4, LPA2
6795	LPAR2-SIVA1 complex	Human	None	HEK 293T cells, LPA1/2 double knock-out mouse embryonic fibroblasts	O15304;Q9HBW0	10572;9170	MI:0019-coimmunoprecipitation;MI:0416-fluorescence microscopy	GO:0042981	regulation of apoptotic process	None	None	19293149	Siva-1 colocalized with LPA2 and S1P4 but not S1P1 in the cytosol in LPA1/2 DKO MEFs (double knock-out mouse embryonic fibroblasts).	None	None	Homo sapiens (Human);Homo sapiens (Human)	Apoptosis regulatory protein Siva;Lysophosphatidic acid receptor 2	SIVA1;LPAR2	SIVA;EDG4, LPA2
6796	SIVA1-S1PR4 complex	Human	SIVA1-S1P4 complex	HEK 293T cells, LPA1/2 double knock-out mouse embryonic fibroblasts	O15304;O95977	10572;8698	MI:0019-coimmunoprecipitation;MI:0416-fluorescence microscopy	None	None	None	None	19293149	Siva-1 colocalized with LPA2 and S1P4 but not S1P1 in the cytosol in LPA1/2 DKO MEFs (double knock-out mouse embryonic fibroblasts).	None	None	Homo sapiens (Human);Homo sapiens (Human)	Apoptosis regulatory protein Siva;Sphingosine 1-phosphate receptor 4	SIVA1;S1PR4	SIVA;EDG6
6797	LPAR2-SIVA1 complex	Human	None	HEK 293T cells, HeLa cells, LPA1/2 double knock-out mouse embryonic fibroblasts, NIH 3T3 cells	O15304;Q9HBW0	10572;9170	MI:0019-coimmunoprecipitation;MI:0416-fluorescence microscopy	GO:0042981	regulation of apoptotic process	None	None	17965021	Endogenous Siva-1 was found to co-immunoprecipitate with the LPA2receptor in DKO-LPA2 MEFs (LPA1/2 double knock-out mouse embryonic fibroblasts).Prolonged LPA stimulation promotes the association of Siva-1 with the LPA2receptor and targets both proteins for ubiquitination and degradation.Siva-1 is predominantly present in the nucleus but co-localizes with the LPA2receptor in the cytosol or on the plasma membrane	None	None	Homo sapiens (Human);Homo sapiens (Human)	Apoptosis regulatory protein Siva;Lysophosphatidic acid receptor 2	SIVA1;LPAR2	SIVA;EDG4, LPA2
6798	S1PR1-c-Met-ITGB4 complex, HGF- or S1P-induced	Human	c-Met signaling complex, HGF- or S1P-induced	Human lung microvascular EC (endothelial cells), (HLMVEC), Human pulmonary artery EC (HPAEC)	P08581;P16144;P21453	4233;3691;1901	MI:0019-coimmunoprecipitation	GO:0061028;GO:0045121	establishment of endothelial barrier;membrane raft	None	None	23212923	The c-Met-S1PR1-ITGB4 complex is dynamically regulated within the lipid rafts in response to HGF.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Hepatocyte growth factor receptor;Integrin beta-4;Sphingosine 1-phosphate receptor 1	MET;ITGB4;S1PR1	None;None;CHEDG1 EDG1
6799	VEGFR2-S1PR1-ERK1/2-PKC-alpha complex	Human	None	ML-1 thyroid follicular cancer cells	P17252;P21453;P27361;P28482;P35968	5578;1901;5595;5594;3791	MI:0019-coimmunoprecipitation	GO:0016477;GO:0070371	cell migration;ERK1 and ERK2 cascade	34.05.01	cell migration	20501673	S1P receptors form complexes with VEGFR-2 and the S1P1/VEGFR-2 complex associates with protein kinase C (PKC)-alpha and ERK1/2.The authors hypothesize that VEGFR-2 forms a signaling complex with S1P1, evoking bidirectional signaling regulating both ERK1/2 phosphorylation and haptotaxis of ML-1 cells.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein kinase C alpha type;Sphingosine 1-phosphate receptor 1;Mitogen-activated protein kinase 3;Mitogen-activated protein kinase 1;Vascular endothelial growth factor receptor 2	PRKCA;S1PR1;MAPK3;MAPK1;KDR	PKCA PRKACA;CHEDG1 EDG1;ERK1 PRKM3;ERK2 PRKM1 PRKM2;FLK1 VEGFR2
6800	VEGFR2-S1PR2-ERK1/2-PKC-alpha complex	Human	KDR-S1P2-ERK1/2-PKC-alpha complex	ML-1 thyroid follicular cancer cells	O95136;P17252;P27361;P28482;P35968	9294;5578;5595;5594;3791	MI:0019-coimmunoprecipitation	GO:0016477;GO:0070371	cell migration;ERK1 and ERK2 cascade	34.05.01	cell migration	20501673	S1P receptors form complexes with VEGFR-2 and the S1P2/VEGFR-2 complex associates with protein kinase C (PKC)-alpha and ERK1/2.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Sphingosine 1-phosphate receptor 2;Protein kinase C alpha type;Mitogen-activated protein kinase 3;Mitogen-activated protein kinase 1;Vascular endothelial growth factor receptor 2	S1PR2;PRKCA;MAPK3;MAPK1;KDR	EDG5;PKCA PRKACA;ERK1 PRKM3;ERK2 PRKM1 PRKM2;FLK1 VEGFR2
6801	VEGFR2-S1PR3-ERK1/2-PKC-alpha complex	Human	KDR-S1P3-ERK1/2-PKC-alpha complex	ML-1 thyroid follicular cancer cells	P17252;P27361;P28482;P35968;Q99500	5578;5595;5594;3791;1903	MI:0019-coimmunoprecipitation	GO:0016477;GO:0070371	cell migration;ERK1 and ERK2 cascade	34.05.01	cell migration	20501673	S1P receptors form complexes with VEGFR-2 and the S1P3/VEGFR-2 complex associates with protein kinase C (PKC)-alpha and ERK1/2.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein kinase C alpha type;Mitogen-activated protein kinase 3;Mitogen-activated protein kinase 1;Vascular endothelial growth factor receptor 2;Sphingosine 1-phosphate receptor 3	PRKCA;MAPK3;MAPK1;KDR;S1PR3	PKCA PRKACA;ERK1 PRKM3;ERK2 PRKM1 PRKM2;FLK1 VEGFR2;C9orf108 C9orf47 EDG3
6802	VEGFR2-S1PR5-ERK1/2-PKC-alpha complex	Human	KDR-S1P5-ERK1/2-PKC-alpha complex	ML-1 thyroid follicular cancer cells	P17252;P27361;P28482;P35968;Q9H228	5578;5595;5594;3791;53637	MI:0019-coimmunoprecipitation	GO:0016477;GO:0070371	cell migration;ERK1 and ERK2 cascade	34.05.01	cell migration	20501673	S1P receptors form complexes with VEGFR-2 and the S1P5/VEGFR-2 complex associates with protein kinase C (PKC)-alpha and ERK1/2.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein kinase C alpha type;Mitogen-activated protein kinase 3;Mitogen-activated protein kinase 1;Vascular endothelial growth factor receptor 2;Sphingosine 1-phosphate receptor 5	PRKCA;MAPK3;MAPK1;KDR;S1PR5	PKCA PRKACA;ERK1 PRKM3;ERK2 PRKM1 PRKM2;FLK1 VEGFR2;EDG8
6805	S1PR1\u2013beta-arrestin 2 complex, ApoM(+)HDL-S1P stimulated	Human	S1P1-ARRB2 complex,  ApoM(+)HDL-S1P stimulated	HUVECs (Human umbilical vein endothelial cells)	P21453;P32121	1901;409	MI:0019-coimmunoprecipitation	GO:0050728;GO:0043124	negative regulation of inflammatory response;negative regulation of I-kappaB kinase/NF-kappaB signaling	None	None	26268607	Exposure of HUVECs to ApoM(+)HDL-S1P, but not to albumin-S1P, promoted the formation of a cell surface S1P1\u2013beta-arrestin 2 complex and attenuated the ability of the proinflammatory cytokine TNF to activate NF-kappaB and increase ICAM-1 abundance.	Mouse endothelial S1P1 acted as an anti-inflammatory and anti-atherosclerotic GPCR (G protein-coupled receptor) in vivo.	None	Homo sapiens (Human);Homo sapiens (Human)	Sphingosine 1-phosphate receptor 1;Beta-arrestin-2	S1PR1;ARRB2	CHEDG1 EDG1;ARB2 ARR2
6806	IGF1R-CXCR4-GNAI2-GNB1 complex	Human	None	highly metastatic MDA-MB-231, non-metastatic MCF-7 breast cancer cells	P04899;P08069;P61073;P62873	2771;3480;7852;2782	MI:0006-anti bait coimmunoprecipitation	GO:0016477	cell migration	34.05.01	cell migration	16172123	The results show the existence of a constitutive complex between IGF-1R, CXCR4, Gialpha2, and Gbeta.Both Gialpha2 and Gbeta are associated with the complex in both cell lines; however, activation of the complex, as determined by release of Gialpha2 and Gbeta from CXCR4, only occurs in MDA-MB-231 cells.	CXCR4 seems to play an important role for in cancer.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(i) subunit alpha-2;Insulin-like growth factor 1 receptor;C-X-C chemokine receptor type 4;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	GNAI2;IGF1R;CXCR4;GNB1	GNAI2B;None;None;None
6807	ADRA1A-CXCR4 complex	Human	Alpha-1-adrenergic receptor-CXCR4 complex	VSMCs (vascular smooth muscle cells), HeLa cells	P35348;P61073	148;7852	MI:0019-coimmunoprecipitation	GO:0008217	regulation of blood pressure	None	None	25775528	Disruption of alpha-1A/B-adrenergic receptor-CXCR4 heteromeric complexes inhibits alpha1-AR\u2013mediated functions in vascular smooth muscle cells and treatment with CXCR4 agonists enhances the potency of the alpha-1-AR agonist phenylephrine to increase blood pressure.	Compounds targeting the alpha-1A/B-adrenergic receptor-CXCR4 heteromeric complexes could provide an alternative pharmacological approach tomodulating blood pressure.	None	Homo sapiens (Human);Homo sapiens (Human)	Alpha-1A adrenergic receptor;C-X-C chemokine receptor type 4	ADRA1A;CXCR4	ADRA1C;None
6808	ADRB1-CXCR4 complex	Human	Beta-1-adrenergic receptor-CXCR4 complex	VSMCs (vascular smooth muscle cells), HeLa cells	P08588;P61073	153;7852	MI:0019-coimmunoprecipitation	GO:0008217	regulation of blood pressure	None	None	25775528	Disruption of alpha-1A/B-adrenergic receptor-CXCR4 heteromeric complexes inhibits alpha1-AR\u2013mediated functions in vascular smooth muscle cells and treatment with CXCR4 agonists enhances the potency of the alpha-1-AR agonist phenylephrine to increase blood pressure.	Compounds targeting the alpha-1A/B-adrenergic receptor-CXCR4 heteromeric complexes could provide an alternative pharmacological approach to modulating blood pressure.	None	Homo sapiens (Human);Homo sapiens (Human)	Beta-1 adrenergic receptor;C-X-C chemokine receptor type 4	ADRB1;CXCR4	ADRB1R, B1AR;None
6811	RXFP1 signalosome	Human	RXFP1-AKAP79-AC2-ARRB2-PDE4D3-PKA-alpha complex	HEK293 cells	P17612;P24588;P32121;Q08462;Q08499-2;Q9HBX9	5566;9495;409;108;5144;59350	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0007186;GO:0043949;GO:0009725	G protein-coupled receptor signaling pathway;regulation of cAMP-mediated signaling;response to hormone	30.05.02.24	G-protein coupled receptor signalling pathway	20664520	AC2 interacts with RXFP1 through AKAP79, whereas the association with PDE4D3 and PKA depends upon beta-arrestin 2 binding to Ser(704).The experiments present a constitutively active GPCR signalosome, that couples the relaxin receptor, RXFP1, to cAMP following receptor stimulation with sub-picomolar concentrations of peptide.	None	PDE4D3 is a splice variant of PDE4D.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	cAMP-dependent protein kinase catalytic subunit alpha;A-kinase anchor protein 5;Beta-arrestin-2;Adenylate cyclase type 2;Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D;Relaxin receptor 1	PRKACA;AKAP5;ARRB2;ADCY2;PDE4D;RXFP1	PKACA;AKAP79;ARB2 ARR2;KIAA1060;DPDE3;LGR7
6815	DRD4-KLHL12-CUL3 complex	Human	D4 receptor-KLHL12-CUL3 complex	HEK293T cells	P21917;Q13618;Q53G59	1815;8452;59349	MI:0007-anti tag coimmunoprecipitation	GO:0031396	regulation of protein ubiquitination	None	None	18303015	The D4 receptor does not directly interact with Cul3 but is recruited to the E3 ligase via KLHL12 as an adaptor. This complex formation specifically targets the D4receptor for ubiquitination. The experiments indicate that the D4-KLHL12 association could be human (primate)-specific.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	D(4) dopamine receptor;Cullin-3;Kelch-like protein 12	DRD4;CUL3;KLHL12	None;KIAA0617;C3IP1
6816	ULK1-ATG13-ATG14-PIK3C3 complex	Human	None	HEK293T cells; HCT116 cells	O75143;O75385;Q6ZNE5;Q8NEB9	9776;8408;22863;5289	MI:0019-coimmunoprecipitation	GO:0000045;GO:0010506	autophagosome assembly;regulation of autophagy	None	None	27046250	ATG13, a binding partner of ULK1, mediates the interaction of ULK1 with the ATG14-containing PIK3C3/VPS34 complex, the key machinery for initiation of autophagosome formation. ULK1 binds ATG14 via ATG13 and phosphorylates ATG14 Ser29 when cells are starved of nutrients or treated with MTOR inhibitors.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Autophagy-related protein 13;Serine/threonine-protein kinase ULK1;Beclin 1-associated autophagy-related key regulator;Phosphatidylinositol 3-kinase catalytic subunit type 3	ATG13;ULK1;ATG14;PIK3C3	KIAA0652;KIAA0722;ATG14L KIAA0831;VPS34
6817	Ubiquitin E3 ligase (CUL1, FBXO18, RBX1, SKP1A)	Human	SCF-hFBH1 complex	transfected Sf9 cells	P62877;P63208;Q13616;Q8NFZ0	9978;6500;8454;84893	MI:0047-far western blotting	GO:0016567;GO:0032508;GO:0031146;GO:0006511	protein ubiquitination;DNA duplex unwinding;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;ubiquitin-dependent protein catabolic process	14.07.05;14.13.01.01	modification by ubiquitination, deubiquitination;proteasomal degradation (ubiquitin/proteasomal pathway)	15118074	The SCF-hFBH1 complex can act as a DNA helicase and E3 ubiquitin ligase simultaneously.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase RBX1;S-phase kinase-associated protein 1;Cullin-1;F-box DNA helicase 1	RBX1;SKP1;CUL1;FBH1	RNF75 ROC1;EMC19 OCP2 SKP1A TCEB1L;None;FBX18 FBXO18
6819	APOL1 complex A (APOL1, APOA1, HPR, C3)	Human	None	serum of  eighty-four unrelated healthy African Americans without nephropathy	O14791;P00739;P01024;P02647	8542;3250;718;335	MI:0019-coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0097006	regulation of plasma lipoprotein particle levels	None	None	26586272	APOL1 complex A is larger than typical HDL particles (8\u201312 nm), with similar distributions noted across APOL1 G0/G0, G1/G1, and G2/G2  genotypes. Based on the results from three fractionation procedures, APOL1-containing complexes do not appear to reside in typical se-rum HDL particles, as de?ned by density, charge, and size.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Apolipoprotein L1;Haptoglobin-related protein;Complement C3;Apolipoprotein A-I	APOL1;HPR;C3;APOA1	APOL;None;CPAMD1;None
6820	APOL1 complex B (APOL1, APOA1, HPR, FN1, IGHM)	Human	None	serum of  eighty-four unrelated healthy African Americans without nephropathy	O14791;P00739;P01871;P02647;P02751	8542;3250;3507;335;2335	MI:0019-coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0097006	regulation of plasma lipoprotein particle levels	None	None	26586272	Based on the results from three fractionation procedures, APOL1-containing complexes do not appear to reside in typical serum HDL particles, as defined by density, charge, and size.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Apolipoprotein L1;Haptoglobin-related protein;Immunoglobulin heavy constant mu;Apolipoprotein A-I;Fibronectin	APOL1;HPR;IGHM;APOA1;FN1	APOL;None;None;None;FN
6821	TTR-RBP complex	Human	TTR-RBP4 complex	None	P02753;P02766	5950;7276	MI:0053-fluorescence polarization spectroscopy	GO:0071938;GO:0006776;GO:0016918	vitamin A transport;vitamin A metabolic process;retinal binding	None	None	8639713	The removal o f retinol from holoRBP leads to a six-fold weaker affinity for TTR.  Retinoic acid-RBP possesses a four-fold weaker affinity for TTR. compared with retinol- RBP.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Retinol-binding protein 4;Transthyretin	RBP4;TTR	None;PALB
6822	ZAG-PIP complex	Human	AZGP1-PIP complex	seminal plasma	P12273;P25311	5304;563	MI:0071-molecular sieving	GO:0050544	arachidonic acid binding	None	None	18563756	Fluorescence analysis reveals that complexes have similar binding affinities as native ZAG, for their proposed ligands like arachidonic acid, polyethylene glycol and synthetic peptide.	Both proteins are reported to be androgen regulated and considered as a prognostic marker for prostate and breast carcinomas.	None	Homo sapiens (Human);Homo sapiens (Human)	Prolactin-inducible protein;Zinc-alpha-2-glycoprotein	PIP;AZGP1	GCDFP15 GPIP4;ZAG, ZNGP1
6823	CP\u2013LF\u2013MPO complex	Human	None	None	P00450;P02788;P05164	1356;4057;4353	MI:0071-molecular sieving;MI:0413-electrophoretic mobility shift assay	GO:0006952;GO:0006979	defense response;response to oxidative stress	32.01.01	oxidative stress response	17511605	The fact that CP provides the incorporation of oxidized iron into LF also suggests the participation of the triple CP\u2013LF\u2013MPO complex  in protective reactions in the organism.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Ceruloplasmin;Lactotransferrin;Myeloperoxidase	CP;LTF;MPO	None;GIG12 LF;None
6824	CP-LF complex	Human	None	None	P00450;P02788	1356;4057	MI:0071-molecular sieving;MI:0413-electrophoretic mobility shift assay	GO:0055072	iron ion homeostasis	None	None	17511605	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Ceruloplasmin;Lactotransferrin	CP;LTF	None;GIG12 LF
6825	CP-MPO complex	Human	None	None	P00450;P05164	1356;4353	MI:0071-molecular sieving;MI:0413-electrophoretic mobility shift assay	GO:0006952	defense response	None	None	17511605	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Ceruloplasmin;Myeloperoxidase	CP;MPO	None;None
6826	Calprotectin heterotetramer	Human	(S100A8/S100A9)2 heterotetramer	None	P05109;P06702	6279;6280	MI:0114-x-ray crystallography	GO:0006954;GO:0045087;GO:0005509	inflammatory response;innate immune response;calcium ion binding	36.25.16.07;36.25.16.01;16.17.01	inflammatory response;innate immune response (invertebrates and vertebrates);calcium binding	17553524	None	Increased serum levels of calprotectin are observed in rheumatoid arthritis, various autoimmune diseases, cystic fibrosis, chronical bronchitis, acute allograft rejection, gut inflammation as well as inflammatory dermatoses and abscesses.	None	Homo sapiens (Human);Homo sapiens (Human)	Protein S100-A8;Protein S100-A9	S100A8;S100A9	CAGA CFAG MRP8;CAGB, CFAG, MRP14
6827	iNOS-S100A8/A9 complex	Human	None	peripheral blood monocytes (PBM)	P05109;P06702;P35228	6279;6280;4843	MI:0019-coimmunoprecipitation	GO:0018119;GO:0005509	peptidyl-cysteine S-nitrosylation;calcium ion binding	16.17.01	calcium binding	25417112	IFN-gamma and LDL(ox) synergistically induce iNOS expression, and initiate the assembly of a S-nitrosylase complex consisting of iNOS and S100A8/A9. iNOS-S100A8/A9 directs selective S-nitrosylation of multiple targets, including GAPDH.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein S100-A8;Protein S100-A9;Nitric oxide synthase, inducible	S100A8;S100A9;NOS2	CAGA CFAG MRP8;CAGB, CFAG, MRP14;NOS2A
6828	FGF21-FGFR1c-KLB complex	Human	FGF21-FGFR1c-beta-Klotho complex	293 T cells	P11362;Q86Z14;Q9NSA1	2260;152831;26291	MI:0107-surface plasmon resonance	GO:0008543	fibroblast growth factor receptor signaling pathway	30.05.01.12.03	FGF-receptor signalling pathway	22248288	The D1-linker region of FGFR1c negatively regulates the formation of the FGF21/FGFR1c/beta-Klotho ternary complex. The D1-linker region of FGFR1c prevents direct FGF21 binding to FGFR1c so that no receptor activation occurs in the absence of beta-Klotho.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Fibroblast growth factor receptor 1;Beta-klotho;Fibroblast growth factor 21	FGFR1;KLB;FGF21	BFGFR CEK FGFBR FLG FLT2 HBGFR;None;None
6832	FGF19-FGFR4-KLB complex, heparin induced	Human	None	HEK 293 cells, liver (mouse)	O95750;P22455;Q86Z14	9965;2264;152831	MI:0019-coimmunoprecipitation	GO:0070374;GO:0008543;GO:0001934	positive regulation of ERK1 and ERK2 cascade;fibroblast growth factor receptor signaling pathway;positive regulation of protein phosphorylation	30.05.01.12.03	FGF-receptor signalling pathway	17627937	The results show that KLB is required for FGF19 binding to the cell surface FGFR4 and that heparin promotes this interaction.FGF19 requires KLB for binding to FGFR4, intracellular signaling, and downstreamgene modulation. The requirement for KLB restricts the endocrine activity of FGF19 to tissues that express both FGFR4 and KLB. The liver-specific activity of FGF19 is supported by this molecular mechanism.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Fibroblast growth factor 19;Fibroblast growth factor receptor 4;Beta-klotho	FGF19;FGFR4;KLB	None;JTK2 TKF;None
6833	FGFR4-KLB complex	Human	None	HepG2 cells	P22455;Q86Z14	2264;152831	MI:0019-coimmunoprecipitation	GO:0008543	fibroblast growth factor receptor signaling pathway	30.05.01.12.03	FGF-receptor signalling pathway	17627937	KLB and FGFR4 form a constitutive heparin- and ligand-independent complex.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Fibroblast growth factor receptor 4;Beta-klotho	FGFR4;KLB	JTK2 TKF;None
6834	FGF21-FGFR1c-KLB complex	Human	FGF21-FGFR1c-beta-Klotho complex	293 T cells	P11362;Q86Z14;Q9NSA1	2260;152831;26291	MI:0096-pull down	GO:0008543;GO:0070374	fibroblast growth factor receptor signaling pathway;positive regulation of ERK1 and ERK2 cascade	30.05.01.12.03	FGF-receptor signalling pathway	17452648	Beta-Klotho\u2013FGFR1c and beta-Klotho\u2013FGFR4 complexes were able to pull down FGF21 more efficiently than FGFRs alone and the other beta-Klotho\u2013FGFR combinations.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Fibroblast growth factor receptor 1;Beta-klotho;Fibroblast growth factor 21	FGFR1;KLB;FGF21	BFGFR CEK FGFBR FLG FLT2 HBGFR;None;None
6835	FGF21-FGFR4-KLB complex	Human	FGF21-FGFR4-beta-Klotho complex	293 T cells	P22455;Q86Z14;Q9NSA1	2264;152831;26291	MI:0096-pull down	GO:0008543;GO:0070374	fibroblast growth factor receptor signaling pathway;positive regulation of ERK1 and ERK2 cascade	30.05.01.12.03	FGF-receptor signalling pathway	17452648	Beta-Klotho\u2013FGFR1c and beta-Klotho\u2013FGFR4 complexes were able to pull down FGF21 more efficiently than FGFRs alone and the other beta-Klotho\u2013FGFR combinations.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Fibroblast growth factor receptor 4;Beta-klotho;Fibroblast growth factor 21	FGFR4;KLB;FGF21	JTK2 TKF;None;None
6836	FGFR1c-KLB complex	Human	FGFR1c-beta-Klotho complex	293 cell lysates	P11362;Q86Z14	2260;152831	MI:0019-coimmunoprecipitation	GO:0008543	fibroblast growth factor receptor signaling pathway	30.05.01.12.03	FGF-receptor signalling pathway	17452648	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Fibroblast growth factor receptor 1;Beta-klotho	FGFR1;KLB	BFGFR CEK FGFBR FLG FLT2 HBGFR;None
6837	FGFR4-KLB complex	Human	FGFR4-beta-Klotho complex	293 cell lysates	P22455;Q86Z14	2264;152831	MI:0019-coimmunoprecipitation	GO:0008543	fibroblast growth factor receptor signaling pathway	30.05.01.12.03	FGF-receptor signalling pathway	17452648	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Fibroblast growth factor receptor 4;Beta-klotho	FGFR4;KLB	JTK2 TKF;None
6838	IGF2BP1 complex	Human	None	HEK293 cells	O60506;O95793;P61254;P62753;P67809;Q00839;Q08211;Q15717;Q9NZI8	10492;6780;6154;6194;4904;3192;1660;1994;10642	MI:0007-anti tag coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0048255;GO:0005737	mRNA stabilization;cytoplasm	70.03	cytoplasm	19029303	The IGF2BP1 complex stabilizes the c-myc RNA by associating with the Coding Region instability Determinant (CRD).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Heterogeneous nuclear ribonucleoprotein Q;Double-stranded RNA-binding protein Staufen homolog 1;60S ribosomal protein L26;40S ribosomal protein S6;Y-box-binding protein 1;Heterogeneous nuclear ribonucleoprotein U;ATP-dependent RNA helicase A;ELAV-like protein 1;Insulin-like growth factor 2 mRNA-binding protein 1	SYNCRIP;STAU1;RPL26;RPS6;YBX1;HNRNPU;DHX9;ELAVL1;IGF2BP1	HNRPQ NSAP1;STAU;None;None;NSEP1 YB1;C1orf199 HNRPU SAFA U21.1;DDX9 LKP NDH2;HUR;CRDBP VICKZ1 ZBP1
6842	EphA1 receptor signaling complex	Human	None	HEK293T cells	P06239;P21709;P27986;Q14289	3932;2041;5295;2185	MI:0019-coimmunoprecipitation	GO:0072678;GO:0023052	T cell migration;signaling	30.01	cellular signalling	17634955	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Tyrosine-protein kinase Lck;Ephrin type-A receptor 1;Phosphatidylinositol 3-kinase regulatory subunit alpha;Protein-tyrosine kinase 2-beta	LCK;EPHA1;PIK3R1;PTK2B	None;EPH EPHT EPHT1;GRB1;FAK2 PYK2 RAFTK
6844	NIF-1-DBC1-EMSY complex	Human	ZNF335-CCAR2-EMSY complex	293T cells, HeLa S3 cells	Q7Z589;Q8N163;Q9H4Z2	56946;57805;63925	MI:0004-affinity chromatography technology;MI:0071-molecular sieving	GO:0048384;GO:0006351	retinoic acid receptor signaling pathway;DNA-templated transcription	11	TRANSCRIPTION	19131338	The results imply that DBC-1 and EMSY, as components of a NIF-1 complex, play an important role in the RA-mediated stimulation of Sox9 and HoxA1 by RAR-alpha.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	BRCA2-interacting transcriptional repressor EMSY;Cell cycle and apoptosis regulator protein 2;Zinc finger protein 335	EMSY;CCAR2;ZNF335	C11orf30;DBC1 KIAA1967;None
6845	NIF1-ASH2L-RBBP5-WDR5 complex	Human	ZNF335-ASH2L-RBBP5-WDR5 complex	293T cells, HeLa S3 cells	P61964;Q15291;Q9H4Z2;Q9UBL3	11091;5929;63925;9070	MI:0004-affinity chromatography technology;MI:0071-molecular sieving	GO:0016571	histone methylation	None	None	19131338	The isolated NIF-1 complex contains a H3 methyltransferase activity that methylates one or more residues other than H3-Lys-4 (H3K4).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	WD repeat-containing protein 5;Retinoblastoma-binding protein 5;Zinc finger protein 335;Set1/Ash2 histone methyltransferase complex subunit ASH2	WDR5;RBBP5;ZNF335;ASH2L	BIG3;RBQ3;None;ASH2L1
6846	DBC1-SIRT1 complex	Human	CCAR2-SIRT1 complex	HeLa cells, U2OS cells	Q8N163;Q96EB6	57805;23411	MI:0004-affinity chromatography technology;MI:0006-anti bait coimmunoprecipitation	GO:0090311;GO:0043065	regulation of protein deacetylation;positive regulation of apoptotic process	None	None	18235502	DBC1 inhibits SIRT1-mediated deacetylation of p53. DBC1-mediated inhibitory effects specifically act on SIRT1 deacetylase activity. DBC1 promotes p53-mediated apoptosis through specific inhibition of SIRT1.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cell cycle and apoptosis regulator protein 2;NAD-dependent protein deacetylase sirtuin-1	CCAR2;SIRT1	DBC1 KIAA1967;SIR2L1
6847	DBIRD complex	Human	DBC1-ZIRD complex, CCAR2-ZNF326 complex	HEK 293 cells	Q5BKZ1;Q8N163	284695;57805	MI:0019-coimmunoprecipitation;MI:0071-molecular sieving	GO:0000381;GO:0006368	regulation of alternative mRNA splicing, via spliceosome;transcription elongation by RNA polymerase II promoter	None	None	22446626	DBC1 and ZIRD form a stable complex that binds RNAPII (RNA polymerase II). DBIRD complex acts at the interface between mRNP (messengerribonucleoprotein particle) particles and RNAPII, integratingtranscript elongation with the regulation of alternative splicing.	None	None	Homo sapiens (Human);Homo sapiens (Human)	DBIRD complex subunit ZNF326;Cell cycle and apoptosis regulator protein 2	ZNF326;CCAR2	ZIRD;DBC1 KIAA1967
6848	IRF2BP2-IRF2BP1-IRF2BPL complex	Human	DIF-1-BP1-EAP1 complex, DIF-1 complex	HeLa cells, T-47D cells	Q7Z5L9;Q8IU81;Q9H1B7	359948;26145;64207	MI:0004-affinity chromatography technology	GO:0045892;GO:0042981	negative regulation of DNA-templated transcription;regulation of apoptotic process	11.02.03.04.03	transcription repression	21444724	The authors identified FASTKD2 (Fas-activated serine-threonine kinase domain 2) as a target gene of the DIF-1 complex in breast cancer cells. The DIF-1-BP1-EAP1 complex binds to and selectively represses the FASTKD2 gene in breast cancer cells. FASTKD2 is proapoptotic.All the breast cancer cell lines that have been studied (whether estrogen receptor positive or negative) undergo apoptosis when DIF-1 is knocked down or inactivated bythe binding of NRIF3/DD1.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Interferon regulatory factor 2-binding protein 2;Interferon regulatory factor 2-binding protein 1;Probable E3 ubiquitin-protein ligase IRF2BPL	IRF2BP2;IRF2BP1;IRF2BPL	None;None;C14orf4 EAP1 KIAA1865
6849	WRAD  complex (WDR5, RBBP5, ASH2L, DPY30)	Human	None	None	P61964;Q15291;Q9C005;Q9UBL3	11091;5929;84661;9070	MI:0027-cosedimentation	GO:0097692	histone H3-K4 monomethylation	None	None	21106533	Histone H3 is the preferred substrate for isolated human WRAD, which, in the absence of MLL1, preferentially monomethylates lysine 4. WDR5, RbBP5, and Ash2L form the minimal complex (WRA complex) required for methylation of histone H3 and that DPY-30 (WRAD complex) functions to enhance complex stability and enzymatic activity.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	WD repeat-containing protein 5;Retinoblastoma-binding protein 5;Protein dpy-30 homolog;Set1/Ash2 histone methyltransferase complex subunit ASH2	WDR5;RBBP5;DPY30;ASH2L	BIG3;RBQ3;None;ASH2L1
6850	WRA complex (WDR5, RBBP5, ASH2L)	Human	None	None	P61964;Q15291;Q9UBL3	11091;5929;9070	MI:0027-cosedimentation	GO:0097692	histone H3-K4 monomethylation	None	None	21106533	WDR5, RbBP5, and Ash2L form the minimal complex required for methylation of histone H3 and that DPY-30 (WRAD complex) functions to enhance complex stability and enzymatic activity.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	WD repeat-containing protein 5;Retinoblastoma-binding protein 5;Set1/Ash2 histone methyltransferase complex subunit ASH2	WDR5;RBBP5;ASH2L	BIG3;RBQ3;ASH2L1
6851	MWRAD complex (MLL1, WDR5, RBBP5, ASH2L, DPY30)	Human	None	None	P61964;Q03164;Q15291;Q9C005;Q9UBL3	11091;4297;5929;84661;9070	MI:0027-cosedimentation	GO:0097692;GO:0044648	histone H3-K4 monomethylation;histone H3-K4 dimethylation	None	None	21106533	Nucleosomal histone H3 methylation is observed only when the assays are conducted with a fully assembled MLL1 core complex containing a stoichiometric equivalent of MLL1 and WRAD that catalyzes H3K4 mono- and dimethylation under the applied assay conditions.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	WD repeat-containing protein 5;Histone-lysine N-methyltransferase 2A;Retinoblastoma-binding protein 5;Protein dpy-30 homolog;Set1/Ash2 histone methyltransferase complex subunit ASH2	WDR5;KMT2A;RBBP5;DPY30;ASH2L	BIG3;ALL1 CXXC7 HRX HTRX MLL MLL1 TRX1;RBQ3;None;ASH2L1
6852	COPRS-PRMT5-RUNX1-CBFB complex	Human	COPR5-PRMT5-RUNX1-CBFB complex	U2OS cells	O14744;Q01196;Q13951;Q9NQ92	10419;861;865;55352	MI:0096-pull down	GO:0006351;GO:0042692	DNA-templated transcription;muscle cell differentiation	11	TRANSCRIPTION	22193545	The capacity of COPR5 to associate with CBFB was conirmed by ChIP experiments, suggesting that COPR5 could be targeted via the RUNX1 complex to promoters.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein arginine N-methyltransferase 5;Runt-related transcription factor 1;Core-binding factor subunit beta;Coordinator of PRMT5 and differentiation stimulator	PRMT5;RUNX1;CBFB;COPRS	HRMT1L5 IBP72 JBP1 SKB1;AML1; CBFA2;None;C17orf79 COPR5
6853	COPRS-PRMT5 complex	Human	COPR5-PRMT5 complex	U2OS cells, nuclear extracts	O14744;Q9NQ92	10419;55352	MI:0007-anti tag coimmunoprecipitation;MI:0018-two hybrid;MI:0029-cosedimentation through density gradient;MI:0096-pull down	GO:0043985;GO:0005634;GO:0006355	histone H4-R3 methylation;nucleus;regulation of DNA-templated transcription	70.10;11.02.03.04	nucleus;transcriptional control	18404153	COPR5 favours H4R3 PRMT5-dependent methylation. COPR5 seems to modulate the substrate specificity and/or activity of nuclear PRMT5-containingcomplexes towards histones. COPR5 depletion and overexpression affect CCNE1 promoter expression.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Protein arginine N-methyltransferase 5;Coordinator of PRMT5 and differentiation stimulator	PRMT5;COPRS	HRMT1L5 IBP72 JBP1 SKB1;C17orf79 COPR5
6854	5FMC (Friends of Methylated Chtop) complex	Human	5FMC complex, PELP1-SENP3-WDR18-TEX10-LAS1L complex	293T cell nuclear extracts	Q8IZL8;Q9BV38;Q9H4L4;Q9NXF1;Q9Y4W2	27043;57418;26168;54881;81887	MI:0019-coimmunoprecipitation;MI:0071-molecular sieving	GO:0016926;GO:0006351	protein desumoylation;DNA-templated transcription	14.07.07;11	modification by ubiquitin-related proteins;TRANSCRIPTION	22872859	The interactions between Chtop and 5FMC are most likely transient and highly dynamic. The authors showed that Pelp1 is critical for the integrity of 5FMC and that Chtop and 5FMC are recruited by Zinc finger binding protein-89 (Zbp-89), thereby regulating both (de)sumoylation of, and transactivation by Zbp-89.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Proline-, glutamic acid- and leucine-rich protein 1;WD repeat-containing protein 18;Sentrin-specific protease 3;Testis-expressed protein 10;Ribosomal biogenesis protein LAS1L	PELP1;WDR18;SENP3;TEX10;LAS1L	HMX3 MNAR;None;SSP3, SUSP3;None;None
6855	LAS1L-PELP1-TEX10-WDR18-NOL9-SENP3  complex	Human	None	HEK 293T cell lysates, HCT116 nuclear cell extracts	Q5SY16;Q8IZL8;Q9BV38;Q9H4L4;Q9NXF1;Q9Y4W2	79707;27043;57418;26168;54881;81887	MI:0019-coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0042254;GO:0005730;GO:0006364	ribosome biogenesis;nucleolus;rRNA processing	12.01;70.10.07;11.04.01	ribosome biogenesis;nucleolus;rRNA processing	22190735	The authors demonstrate that all these proteins localize to the nucleolus and cosediment with the pre-60S ribosomal particle and that they are required for efficient processing of the 28S rRNA.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Polynucleotide 5'-hydroxyl-kinase NOL9;Proline-, glutamic acid- and leucine-rich protein 1;WD repeat-containing protein 18;Sentrin-specific protease 3;Testis-expressed protein 10;Ribosomal biogenesis protein LAS1L	NOL9;PELP1;WDR18;SENP3;TEX10;LAS1L	None;HMX3 MNAR;None;SSP3, SUSP3;None;None
6856	PeBoW complex	Human	PES1-BOP1-WDR12 complex	U2OS cells	O00541;Q14137;Q9GZL7	23481;23246;55759	MI:0019-coimmunoprecipitation;MI:0404-comigration in non denaturing gel electrophoresis	GO:0006364;GO:0042254	rRNA processing;ribosome biogenesis	11.04.01;12.01	rRNA processing;ribosome biogenesis	16043514	Most likely, the PeBoW complex is a stable subcomponent of larger preribosomal particles.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Pescadillo homolog;Ribosome biogenesis protein BOP1;Ribosome biogenesis protein WDR12	PES1;BOP1;WDR12	None;KIAA0124;None
6857	PELP1-TEX10-WDR18 complex	Human	None	HEK 293T cells	Q8IZL8;Q9BV38;Q9NXF1	27043;57418;54881	MI:0007-anti tag coimmunoprecipitation	GO:0042254;GO:0006364	ribosome biogenesis;rRNA processing	12.01;11.04.01	ribosome biogenesis;rRNA processing	21326211	The SUMO system controls the spatial distribution of this complex and the associated factors MDN1 and LAS1L.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Proline-, glutamic acid- and leucine-rich protein 1;WD repeat-containing protein 18;Testis-expressed protein 10	PELP1;WDR18;TEX10	HMX3 MNAR;None;None
6858	CHTOP-methylosome complex	Human	CHTOP-methylosome complex, 5-hydroxymethylcytosine associated	HEK293FT cells, GB2 cells	O14744;P84090;Q99873;Q9BQA1;Q9Y3Y2	10419;2079;3276;79084;26097	MI:0007-anti tag coimmunoprecipitation	GO:0043985;GO:0006355;GO:0002056	histone H4-R3 methylation;regulation of DNA-templated transcription;cytosine binding	11.02.03.04	transcriptional control	25284789	The CHTOP-methylosome complex associated with 5hmC (5-hydroxymethylcytosine) methylates H4R3 and transactivates cancer-related genes.	5hmC (5-hydroxymethylcytosine) serves as a recruitment signal for theCHTOP-methylosome complex, which in turn methylates H4R3and thereby activates the transcription of genes required for glioblastomagenesis.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein arginine N-methyltransferase 5;Enhancer of rudimentary homolog;Protein arginine N-methyltransferase 1;Methylosome protein 50;Chromatin target of PRMT1 protein	PRMT5;ERH;PRMT1;WDR77;CHTOP	HRMT1L5 IBP72 JBP1 SKB1;None;HMT2 HRMT1L2 IR1B4;MEP50 WD45;C1orf77 FOP
6859	HRD1 complex	Human	None	HEK 293 cells	O94905;P11021;P14625;P35613;Q13438;Q86TM6;Q96CS3;Q96DZ1;Q9GZP9;Q9UBU6;Q9UBV2;Q9Y385;Q9Y679	11160;3309;7184;682;10956;84447;23197;27248;51009;51439;6400;51465;550	MI:0007-anti tag coimmunoprecipitation;MI:0071-molecular sieving	GO:0034976;GO:0005789	response to endoplasmic reticulum stress;endoplasmic reticulum membrane	None	None	28411238	None	None	Hrd1 forms heterogeneous high-molecular-mass complexes with distinct stoichiometries. Here, components from fraction 12 (see suppl. figure S3A) were annotated.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Erlin-2;Endoplasmic reticulum chaperone BiP;Endoplasmin;Basigin;Protein OS-9;E3 ubiquitin-protein ligase synoviolin;FAS-associated factor 2;Endoplasmic reticulum lectin 1;Derlin-2;Protein FAM8A1;Protein sel-1 homolog 1;Ubiquitin-conjugating enzyme E2 J1;Lipid droplet-regulating VLDL assembly factor AUP1	ERLIN2;HSPA5;HSP90B1;BSG;OS9;SYVN1;FAF2;ERLEC1;DERL2;FAM8A1;SEL1L;UBE2J1;AUP1	C8orf2 SPFH2;GRP78;GRP94, TRA1;None;None;HRD1 KIAA1810;ETEA KIAA0887 UBXD8 UBXN3B;C2orf30 XTP3TPB;DER2; FLANA;AHCP;TSA305;NCUBE1;None
6860	E6AP-HERC2-MAPK6-NEURL4 complex	Human	None	T-REx 293 cells	O95714;Q05086;Q16659;Q96JN8	8924;7337;5597;84461	MI:0007-anti tag coimmunoprecipitation;MI:0071-molecular sieving	GO:0046605	regulation of centrosome cycle	None	None	22645313	E6AP (UBE3) exists as part of several different protein complexes, including the proteasome and an independent high-molecular-weight complex containing HERC2, NEURL4, and MAPK6.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase HERC2;Ubiquitin-protein ligase E3A;Mitogen-activated protein kinase 6;Neuralized-like protein 4	HERC2;UBE3A;MAPK6;NEURL4	None;E6AP EPVE6AP HPVE6A;ERK3,PRKM6;KIAA1787
6861	MMAA-MUT complex	Human	None	HepG2	P22033;Q8IVH4	4594;166785	MI:0007-anti tag coimmunoprecipitation;MI:0071-molecular sieving	GO:0004494	methylmalonyl-CoA mutase activity	None	None	20876572	MMAA has a GTPase activity that is modulated by MUT. Formation of a stable MMAA-MUT complex is nucleotide-selective for MMAA (GMPPNP over GDP) and adenosylcobalamin-dependent for MUT. (PMID: 20876572)	None	None	Homo sapiens (Human);Homo sapiens (Human)	Methylmalonyl-CoA mutase, mitochondrial;Methylmalonic aciduria type A protein, mitochondrial	MMUT;MMAA	MUT;None
6862	Bag6-Ubl4A-Trc35 Complex	Human	Holdase complex	HEK293 cells	P11441;P46379;Q7L5D6	8266;7917;51608	MI:0007-anti tag coimmunoprecipitation	GO:1904294	positive regulation of ERAD pathway	None	None	23246001	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Ubiquitin-like protein 4A;Large proline-rich protein BAG6;Golgi to ER traffic protein 4 homolog	UBL4A;BAG6;GET4	DXS254E GDX UBL4;BAT3 G3;C7orf20,CEE,TRC35
6863	CBX3-EHMT2-NR3C1 complex	Human	HP1-gamma-G9a-GR complex	Cos cells	P04150;Q13185;Q96KQ7	2908;11335;10919	MI:0019-coimmunoprecipitation	GO:0006351	DNA-templated transcription	11	TRANSCRIPTION	28615290	G9a methylation (K185) is required for HP1-gamma-G9a-GR complex formation. G9a phosphorylation (T186) by Aurora kinase B in cells prevents HP1-gamma  recognition.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Glucocorticoid receptor;Chromobox protein homolog 3;Histone-lysine N-methyltransferase EHMT2	NR3C1;CBX3;EHMT2	GRL;None;BAT8 C6orf30 G9A KMT1C NG36
6864	CBX3-EHMT1-NR3C1 complex	Human	HP1-gamma-GLP-GR complex	Cos cells	P04150;Q13185;Q9H9B1	2908;11335;79813	MI:0019-coimmunoprecipitation	GO:0006351	DNA-templated transcription	11	TRANSCRIPTION	28615290	GLP methylation (K205) is required for HP1-gamma-GLP-GR complex formation. GLP phosphorylation (T206) by Aurora kinase B in cells prevents HP1-gamma recognition.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Glucocorticoid receptor;Chromobox protein homolog 3;Histone-lysine N-methyltransferase EHMT1	NR3C1;CBX3;EHMT1	GRL;None;EUHMTASE1 GLP KIAA1876 KMT1D
6866	AMFR-ERLIN2-TMUB1 complex	Human	GP78-SPFH2-TMUB1 complex	HEK-293 cells and CHO-7 cells	O94905;Q9BVT8;Q9UKV5	11160;83590;267	MI:0007-anti tag coimmunoprecipitation	GO:0036503;GO:0005783	ERAD pathway;endoplasmic reticulum	70.07	endoplasmic reticulum	21343306	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Erlin-2;Transmembrane and ubiquitin-like domain-containing protein 1;E3 ubiquitin-protein ligase AMFR	ERLIN2;TMUB1;AMFR	C8orf2 SPFH2;C7orf21 DULP HOPS;RNF45
6871	AMFR-STING-INSIG1 complex, herpes simplex virus 1 induced	Human	None	HEK 293T cells, MEFs (mouse embryonic fibroblasts)	O15503;Q86WV6;Q9UKV5	3638;340061;267	MI:0019-coimmunoprecipitation	GO:0036503;GO:0045087;GO:0016567	ERAD pathway;innate immune response;protein ubiquitination	36.25.16.01;14.07.05	innate immune response (invertebrates and vertebrates);modification by ubiquitination, deubiquitination	25526307	AMFR catalyzed the formation of the K27-linked polyubiquitin chains on STING. INSIG1 bridges AMFR and STING in the intracellular DNA-induced signaling.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Insulin-induced gene 1 protein;Stimulator of interferon genes protein;E3 ubiquitin-protein ligase AMFR	INSIG1;STING1;AMFR	None;ERIS MITA STING TMEM173;RNF45
6873	BAG6-AMFR-FAF2 complex	Human	Bag6-gp78-UbxD8 complex	HEK 293 cells	P46379;Q96CS3;Q9UKV5	7917;23197;267	MI:0007-anti tag coimmunoprecipitation	GO:0071712;GO:0036503;GO:0005789	ER-associated misfolded protein catabolic process;ERAD pathway;endoplasmic reticulum membrane	None	None	23665563	UbxD8 and gp78 were simultaneously present in a Bag6-containing complex. This observation would only be possible if Bag6 forms an oligomer that simultaneously interacts with these factors .	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Large proline-rich protein BAG6;FAS-associated factor 2;E3 ubiquitin-protein ligase AMFR	BAG6;FAF2;AMFR	BAT3 G3;ETEA KIAA0887 UBXD8 UBXN3B;RNF45
6875	CRBN-DDB1-CUL4A-RBX1 E3 ubiquitin ligase	Human	CRBN-DDB1-CUL4A-ROC1 E3 ubiquitin ligase	HeLa cells, HEK 293T cells	P62877;Q13619;Q16531;Q96SW2	9978;8451;1642;51185	MI:0007-anti tag coimmunoprecipitation	GO:0061630;GO:0000151;GO:0048731	ubiquitin protein ligase activity;ubiquitin ligase complex;system development	None	None	20223979	Half a century ago, thalidomide was widely prescribed to pregnant women as a sedative but was found to be teratogenic, causing multiple birth defects. Cereblon (CRBN) was identified as a thalidomide-binding protein. Thalidomide initiates its teratogenic effects by binding to CRBN and inhibiting the associated ubiquitin ligase activity.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase RBX1;Cullin-4A;DNA damage-binding protein 1;Protein cereblon	RBX1;CUL4A;DDB1;CRBN	RNF75 ROC1;None;XAP1;None
6881	EXT1-EXT2 complex	Human	None	BHK cells. Human genes were expressed in hamster cells.	Q16394;Q93063	2131;2132	MI:0007-anti tag coimmunoprecipitation	GO:0005794;GO:0015012	Golgi apparatus;heparan sulfate proteoglycan biosynthetic process	70.08	Golgi	10639137	EXT1 and EXT2 possess GlcA-T and GlcNAc-T activities in vitro. Compared to ETX1 or EXT2 homodimers, the EXT1-EXT2 complex possesses enhanced glycosyltransferase activity.	Inherited mutations in either of the two EXT genes can result in hereditary multiple exostoses.	None	Homo sapiens (Human);Homo sapiens (Human)	Exostosin-1;Exostosin-2	EXT1;EXT2	None;None
6884	Fanconi anemia FAAP100 complex	Human	None	HeLa cells	O15287;O15360;Q00597;Q0VG06;Q8IYD8;Q8NB91;Q9BTP7;Q9HB96;Q9NPI8;Q9NW38	2189;2175;2176;80233;57697;2187;91442;2178;2188;55120	MI:0019-coimmunoprecipitation;MI:0071-molecular sieving	GO:0006974;GO:0005634;GO:0006513	cellular response to DNA damage stimulus;nucleus;protein monoubiquitination	32.01.09;70.10	DNA damage response;nucleus	17396147	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Fanconi anemia group G protein;Fanconi anemia group A protein;Fanconi anemia group C protein;Fanconi anemia core complex-associated protein 100;Fanconi anemia group M protein;Fanconi anemia group B protein;Fanconi anemia core complex-associated protein 24;Fanconi anemia group E protein;Fanconi anemia group F protein;E3 ubiquitin-protein ligase FANCL	FANCG;FANCA;FANCC;FAAP100;FANCM;FANCB;FAAP24;FANCE;FANCF;FANCL	XRCC9;FAA FACA FANCH;FAC FACC;C17orf70;KIAA1596;None;C19orf40;FACE;None;PHF9
6885	L-B-P100 subcomplex	Human	Fanconi anemia subcomplex	HeLa cells	Q0VG06;Q8NB91;Q9NW38	80233;2187;55120	MI:0019-coimmunoprecipitation;MI:0071-molecular sieving	GO:0005634;GO:0005737	nucleus;cytoplasm	70.10;70.03	nucleus;cytoplasm	17396147	L-B-P100 subcomplex is part of the Fanconi anemia core complex. According to a model, the L-B-P100 complex is normally present in the cytosol, and moves to the nucleus when it is associated with FANCA and FANCM.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Fanconi anemia core complex-associated protein 100;Fanconi anemia group B protein;E3 ubiquitin-protein ligase FANCL	FAAP100;FANCB;FANCL	C17orf70;None;PHF9
6886	AUP1-OS9-SEL1L-UBC6e-UBXD8 complex	Human	AUP1-OS9-SEL1L-UBE2J1-FAF2 complex	HeLa cells	Q13438;Q96CS3;Q9UBV2;Q9Y385;Q9Y679	10956;23197;6400;51465;550	MI:0007-anti tag coimmunoprecipitation	GO:0030970;GO:0036503;GO:0005789	retrograde protein transport, ER to cytosol;ERAD pathway;endoplasmic reticulum membrane	None	None	18711132	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein OS-9;FAS-associated factor 2;Protein sel-1 homolog 1;Ubiquitin-conjugating enzyme E2 J1;Lipid droplet-regulating VLDL assembly factor AUP1	OS9;FAF2;SEL1L;UBE2J1;AUP1	None;ETEA KIAA0887 UBXD8 UBXN3B;TSA305;NCUBE1;None
6888	v-ATPase-Ragulator-AXIN/LKB1-AMPK complex	Human	None	HEK293 cells	O15169;O43504;P21281;P27449;P38606;P54619;P61421;Q0VGL1;Q13131;Q15831;Q6IAA8;Q9UHA4;Q9Y2Q5;Q9Y478	8312;10542;526;527;523;5571;9114;389541;5562;6794;55004;8649;28956;5564	MI:0019-coimmunoprecipitation;MI:0416-fluorescence microscopy	GO:0005768;GO:0097009	endosome;energy homeostasis	70.22	endosome	25002183	v-ATPase-Ragulator complex is an initiating sensor for energy stress and meanwhile serves as an endosomal docking site for LKB1-mediated AMPK activation by forming the v-ATPase-Ragulator-AXIN/LKB1-AMPK complex, thereby providing a switch between catabolism and anabolism.	None	Since the authors did not specify AMPK, we used isoforms Prkaa1, Prkab1 and Prkag1.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Axin-1;Ragulator complex protein LAMTOR5;V-type proton ATPase subunit B, brain isoform;V-type proton ATPase 16 kDa proteolipid subunit c;V-type proton ATPase catalytic subunit A;5'-AMP-activated protein kinase subunit gamma-1;V-type proton ATPase subunit d 1;Ragulator complex protein LAMTOR4;5'-AMP-activated protein kinase catalytic subunit alpha-1;Serine/threonine-protein kinase STK11;Ragulator complex protein LAMTOR1;Ragulator complex protein LAMTOR3;Ragulator complex protein LAMTOR2;5'-AMP-activated protein kinase subunit beta-1	AXIN1;LAMTOR5;ATP6V1B2;ATP6V0C;ATP6V1A;PRKAG1;ATP6V0D1;LAMTOR4;PRKAA1;STK11;LAMTOR1;LAMTOR3;LAMTOR2;PRKAB1	AXIN;HBXIP,XIP;ATP6B2,VPP3;ATP6C ATP6L ATPL;ATP6A1 ATP6V1A1 VPP2;None;ATP6D,VPATPD;C7orf59;AMPK1;LKB1 PJS;C11orf59 PDRO;MAP2K1IP1 MAPKSP1;MAPBPIP ROBLD3;AMPK
6889	TSC complex	Human	TSC1-TSC2-TBC1D7; Rhebulator complex; TSC-TBC complex	HeLa cells	P49815;Q92574;Q9P0N9	7249;7248;107080638	MI:0019-coimmunoprecipitation	GO:0005764;GO:0009594;GO:1904263;GO:0008286;GO:0014065	lysosome;detection of nutrient;positive regulation of TORC1 signaling;insulin receptor signaling pathway;phosphatidylinositol 3-kinase signaling	70.25;34.11.12;30.05.01.12.05	vacuole or lysosome;perception of nutrients and nutritional adaptation;insulin receptor signalling pathway	24529379	Insulin activates mTORC1 by inducing dissociation of the TSC complex from the lysosome. Insulin and amino acids independently regulate localization of the TSC complex and mTORC1 to the lysosome and Rheb.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Tuberin;Hamartin;TBC1 domain family member 7	TSC2;TSC1;TBC1D7	TSC4;KIAA0243, TSC;TBC7
6890	Phosphatidylinositol 4-kinase complex	Human	PI4K complex	HEK 293T cells	P42356;Q86TV6;Q8IYD1;Q9BYI3	5297;145567;23708;84668	MI:0007-anti tag coimmunoprecipitation;MI:0040-electron microscopy	GO:0005886;GO:0042552;GO:0006661	plasma membrane;myelination;phosphatidylinositol biosynthetic process	70.02	eukaryotic plasma membrane / membrane attached	26571211	None	Hypomyelination and congenital cataract (HCC) is caused by mutations in FAM126A.	The phosphatidylinositol 4-kinase complex is composed of PI4KA, EFR3 (EFR3A or EFR3B), TTC7 (TTC7A or TTC7B) and FAM126 (FAM126A or FAM126B).	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Phosphatidylinositol 4-kinase alpha;Tetratricopeptide repeat protein 7B;Eukaryotic peptide chain release factor GTP-binding subunit ERF3B;Hyccin	PI4KA;TTC7B;GSPT2;FAM126A	PIK4 PIK4CA;TTC7L1;ERF3B;DRCTNNB1A
6891	HUSH complex	Human	Human silencing hub complex	KBM7 cells	Q8NEY8;Q99549;Q9UK61	51535;54737;23272	MI:0019-coimmunoprecipitation	GO:0005634;GO:0003682;GO:0010629	nucleus;chromatin binding;negative regulation of gene expression	70.10	nucleus	26022416	The HUSH complex mediates epigenetic regulation of both endogenous and viral genes at heterochromatic loci marked by H3K9me3.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Periphilin-1;M-phase phosphoprotein 8;Protein TASOR	PPHLN1;MPHOSPH8;TASOR	None;MPP8;C3orf63 FAM208A KIAA1105
6893	Gamma-tubulin complex	Human	None	HEK 293 cells, U2OS cells	P23258;Q96CW5;Q96RT7;Q96RT8;Q9BSJ2;Q9UGJ1	7283;10426;85378;114791;10844;27229	MI:0019-coimmunoprecipitation;MI:0029-cosedimentation through density gradient;MI:0096-pull down	GO:0005813;GO:0007020;GO:0060271	centrosome;microtubule nucleation;cilium assembly	70.05	centrosome	11694571	The gamma-tubulin complex is present in the cytoplasm and at the centrosome and is thought to be active for nucleation only at the centrosome in vivo. The function of the cytoplasmic gamma-tubulin complex is not known.	None	The antibody used to identify tubulin gamma is TUBG1-specific.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Tubulin gamma-1 chain;Gamma-tubulin complex component 3;Gamma-tubulin complex component 6;Gamma-tubulin complex component 5;Gamma-tubulin complex component 2;Gamma-tubulin complex component 4	TUBG1;TUBGCP3;TUBGCP6;TUBGCP5;TUBGCP2;TUBGCP4	TUBG;GCP3;GCP6 KIAA1669;GCP5, KIAA1899;GCP2;76P, GCP4
6895	MMXD complex	Human	MMS19-MIP18-XPD complex	HEK293 cells	O76071;P05141;P18074;Q96T76;Q9Y3D0	9391;292;2068;64210;51647	MI:0007-anti tag coimmunoprecipitation;MI:0071-molecular sieving	GO:0072686;GO:0051225;GO:0007059	mitotic spindle;spindle assembly;chromosome segregation	10.03.05.01;10.03.04.05	spindle pole body/centrosome and microtubule cycle;chromosome segregation/division	20797633	None	Findings suggest that abnormalities in the function of the MMXD complex due to the XPD mutations lead to aneuploidy and/or cell death, contributing at least partly to the phenotypes such as a high incidence of skin tumors in XP6BE and XPCS-2 patients.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Probable cytosolic iron-sulfur protein assembly protein CIAO1;ADP/ATP translocase 2;General transcription and DNA repair factor IIH helicase subunit XPD;MMS19 nucleotide excision repair protein homolog;Cytosolic iron-sulfur assembly component 2B	CIAO1;SLC25A5;ERCC2;MMS19;CIAO2B	CIA1 WDR39;AAC2 ANT2;XPD XPDC;MMS19L;CIAB FAM96B MIP18
6896	MMS19 complex	Human	None	HEK 293T cells	O76071;Q96T76;Q9H6Q4;Q9Y3D0	9391;64210;64428;51647	MI:0007-anti tag coimmunoprecipitation;MI:0071-molecular sieving	GO:0005737;GO:0006260;GO:0006281	cytoplasm;DNA replication;DNA repair	70.03;10.01.03;10.01.05.01	cytoplasm;DNA synthesis and replication;DNA repair	22678361	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Probable cytosolic iron-sulfur protein assembly protein CIAO1;MMS19 nucleotide excision repair protein homolog;Cytosolic iron-sulfur assembly component 3;Cytosolic iron-sulfur assembly component 2B	CIAO1;MMS19;CIAO3;CIAO2B	CIA1 WDR39;MMS19L;NARFL PRN;CIAB FAM96B MIP18
6897	CIA2B-CIA1-MMS19 complex	Human	CIAO1-FAM96B-MMS19 complex; CIA targeting complex	HeLa cells	O76071;Q96T76;Q9Y3D0	9391;64210;51647	MI:0007-anti tag coimmunoprecipitation	GO:0097361;GO:0051604;GO:0016226	CIA complex;protein maturation;iron-sulfur cluster assembly	None	None	23891004	CIA1 and CIA2B assemble with MMS19, forming the so-called CIA targeting complex that is involved in the biogenesis of the majority of cytosolic and nuclear Fe/S proteins.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Probable cytosolic iron-sulfur protein assembly protein CIAO1;MMS19 nucleotide excision repair protein homolog;Cytosolic iron-sulfur assembly component 2B	CIAO1;MMS19;CIAO2B	CIA1 WDR39;MMS19L;CIAB FAM96B MIP18
6900	Ubiquitin E3 ligase (CUL1, FBXO10, SKP1)	Human	None	HEK 293T cells	P63208;Q13616;Q9UK96	6500;8454;26267	MI:0007-anti tag coimmunoprecipitation	GO:0043065;GO:0006511	positive regulation of apoptotic process;ubiquitin-dependent protein catabolic process	14.13.01.01	proteasomal degradation (ubiquitin/proteasomal pathway)	23431138	FBXO10 is a component of a ubiquitin ligase that can target BCL2 protein for degradation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	S-phase kinase-associated protein 1;Cullin-1;F-box only protein 10	SKP1;CUL1;FBXO10	EMC19 OCP2 SKP1A TCEB1L;None;FBX10,PRMT11
6901	Ubiquitin E3 ligase (CUL1, FBXO6, RBX1, SKP1)	Human	None	COS7 cells	P62877;P63208;Q13616;Q9NRD1	9978;6500;8454;26270	MI:0007-anti tag coimmunoprecipitation	GO:0036503;GO:0006516;GO:0006511	ERAD pathway;glycoprotein catabolic process;ubiquitin-dependent protein catabolic process	14.13.01.01	proteasomal degradation (ubiquitin/proteasomal pathway)	18203720	A family of ubiquitin ligase subunits  (FBXO2, FBXO6, FBXO17, FBXO27, and FBXO44) target glycoproteins through their attached glycans. Each family member has differing specificity for glycosylated substrates.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase RBX1;S-phase kinase-associated protein 1;Cullin-1;F-box only protein 6	RBX1;SKP1;CUL1;FBXO6	RNF75 ROC1;EMC19 OCP2 SKP1A TCEB1L;None;FBG2 FBS2 FBX6
6902	Ubiquitin E3 ligase (CUL1, FBXO17, RBX1, SKP1)	Human	None	COS7 cells	P62877;P63208;Q13616;Q96EF6	9978;6500;8454;115290	MI:0007-anti tag coimmunoprecipitation	GO:0036503;GO:0006516;GO:0006511	ERAD pathway;glycoprotein catabolic process;ubiquitin-dependent protein catabolic process	14.13.01.01	proteasomal degradation (ubiquitin/proteasomal pathway)	18203720	A family of ubiquitin ligase subunits  (FBXO2, FBXO6, FBXO17, FBXO27, and FBXO44) target glycoproteins through their attached glycans. Each family member has differing specificity for glycosylated substrates.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase RBX1;S-phase kinase-associated protein 1;Cullin-1;F-box only protein 17	RBX1;SKP1;CUL1;FBXO17	RNF75 ROC1;EMC19 OCP2 SKP1A TCEB1L;None;FBG4 FBX17 FBX26 FBXO26
6903	Ubiquitin E3 ligase (CUL1, FBXO27, RBX1, SKP1)	Human	None	COS7 cells	P62877;P63208;Q13616;Q8NI29	9978;6500;8454;126433	MI:0007-anti tag coimmunoprecipitation	GO:0036503;GO:0006516;GO:0006511	ERAD pathway;glycoprotein catabolic process;ubiquitin-dependent protein catabolic process	14.13.01.01	proteasomal degradation (ubiquitin/proteasomal pathway)	18203720	A family of ubiquitin ligase subunits  (FBXO2, FBXO6, FBXO17, FBXO27, and FBXO44) target glycoproteins through their attached glycans. Each family member has differing specificity for glycosylated substrates.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase RBX1;S-phase kinase-associated protein 1;Cullin-1;F-box only protein 27	RBX1;SKP1;CUL1;FBXO27	RNF75 ROC1;EMC19 OCP2 SKP1A TCEB1L;None;FBG5,FBX27
6904	Ubiquitin E3 ligase (CUL1, FBXO44, RBX1, SKP1)	Human	None	COS7 cells	P62877;P63208;Q13616;Q9H4M3	9978;6500;8454;93611	MI:0007-anti tag coimmunoprecipitation	GO:0006511	ubiquitin-dependent protein catabolic process	14.13.01.01	proteasomal degradation (ubiquitin/proteasomal pathway)	18203720	A family of ubiquitin ligase subunits  (FBXO2, FBXO6, FBXO17, FBXO27, and FBXO44) target glycoproteins through their attached glycans. Each family member has differing specificity for glycosylated substrates. In contrast to other family members, FBXO44 showed no significant binding to any of the 200 glycans tested.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase RBX1;S-phase kinase-associated protein 1;Cullin-1;F-box only protein 44	RBX1;SKP1;CUL1;FBXO44	RNF75 ROC1;EMC19 OCP2 SKP1A TCEB1L;None;FBG3 FBX30 FBX44 FBX6A FBXO6A
6905	PELI1-IRAK4-IRAK1-TRAF6 complex, IL-1-induced	Human	None	HEK293 cells	P51617;Q96FA3;Q9NWZ3;Q9Y4K3	3654;57162;51135;7189	MI:0019-coimmunoprecipitation	GO:0070498	interleukin-1-mediated signaling pathway	None	None	12496252	The PELI1-IRAK-IRAK4-TRAF6 signaling complex is likely to be intermediate, located between the IL-1 receptor complex and the TAK1 complex in the IL-1 pathway.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Interleukin-1 receptor-associated kinase 1;E3 ubiquitin-protein ligase pellino homolog 1;Interleukin-1 receptor-associated kinase 4;TNF receptor-associated factor 6	IRAK1;PELI1;IRAK4;TRAF6	IRAK;PRISM;None;RNF85
6906	FBXW7-CDX2-GSK3B complex	Human	None	HCT 116 cells	P49841;Q969H0;Q99626	2932;55294;1045	MI:0019-coimmunoprecipitation	GO:0031146;GO:0006511	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;ubiquitin-dependent protein catabolic process	14.13.01.01	proteasomal degradation (ubiquitin/proteasomal pathway)	27470268	Fbw7 targets CDX2 for ubiquitin-mediated proteasome degradation in a GSK3-beta-dependent manner. GSK3-beta, a serine/threonine kinase, may phosphorylate CDX2 in its CPD (Cdc4-phosphodegron) motifs leading to its degradation by Fbw7.	The deregulated expression of CDX2 is often observed in colon cancers.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Glycogen synthase kinase-3 beta;F-box/WD repeat-containing protein 7;Homeobox protein CDX-2	GSK3B;FBXW7;CDX2	None;FBW7 FBX30 SEL10;CDX3
6907	CTNNB1-FERMT2-TCF7L2 complex	Human	Kindlin 2\u2013b-catenin\u2013TCF4 tripartite complex	HEK293T cells	P35222;Q96AC1;Q9NQB0	1499;10979;6934	MI:0007-anti tag coimmunoprecipitation	GO:0005634;GO:0030177	nucleus;positive regulation of Wnt signaling pathway	70.10	nucleus	22699938	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Catenin beta-1;Fermitin family homolog 2;Transcription factor 7-like 2	CTNNB1;FERMT2;TCF7L2	CTNNB;KIND2 MIG2 PLEKHC1;TCF4
6908	CTNNB1-FERMT2-YBX1 complex	Human	None	U-87 MG cells	P35222;P67809;Q96AC1	1499;4904;10979	MI:0019-coimmunoprecipitation;MI:0663-confocal microscopy	GO:1901186;GO:0006355;GO:0005737;GO:0005634	positive regulation of ERBB signaling pathway;regulation of DNA-templated transcription;cytoplasm;nucleus	11.02.03.04;70.03;70.10	transcriptional control;cytoplasm;nucleus	27713156	None	High Kindlin-2 (FERMT2) expression is correlated with high tumor grade and poor prognosis in glioma patients.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Catenin beta-1;Y-box-binding protein 1;Fermitin family homolog 2	CTNNB1;YBX1;FERMT2	CTNNB;NSEP1 YB1;KIND2 MIG2 PLEKHC1
6909	FGF1-FGFR1-ITGB3 complex	Human	None	HUVEC cells	P05106;P05230;P11362	3690;2246;2260	MI:0019-coimmunoprecipitation	GO:0070374;GO:0008543	positive regulation of ERK1 and ERK2 cascade;fibroblast growth factor receptor signaling pathway	30.05.01.12.03	FGF-receptor signalling pathway	20422052	Results suggest that the simultaneous binding of FGFR1 and Integrin beta-3 to FGF1 occurs during FGF signaling.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-3;Fibroblast growth factor 1;Fibroblast growth factor receptor 1	ITGB3;FGF1;FGFR1	GP3A;FGFA;BFGFR CEK FGFBR FLG FLT2 HBGFR
6910	EED-EZH2-PHF19 complex	Human	EED-EZH2-hPCL3 complex	HEK-293T cells, HeLa cells, U2OS cells	O75530;Q15910;Q5T6S3	8726;2146;26147	MI:0007-anti tag coimmunoprecipitation;MI:0071-molecular sieving	GO:0005634	nucleus	70.10	nucleus	21143197	hPCL3 (PHF19) encodes a long isoform, hPCL3L and a smaller isoform, hPCL3S. Both isoforms are widely co-expressed at high levels in medulloblastoma.	Both isoforms of hPCL3 (PHF19) are widely co-expressed at high levels in medulloblastoma.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Polycomb protein EED;Histone-lysine N-methyltransferase EZH2;PHD finger protein 19	EED;EZH2;PHF19	None;KMT6;PCL3
6913	ELN-FBLN2-FBN1 complex	Human	None	HEK 293 cells	P15502;P35555;P98095	2006;2200;2199	MI:0071-molecular sieving;MI:0096-pull down	GO:0050436	microfibril binding	None	None	17255108	Fibulins 2 and Fibulin 5 can act as adaptors between Fibrillin-1 and (Tropo-) elastin.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Elastin;Fibrillin-1;Fibulin-2	ELN;FBN1;FBLN2	None;FBN;None
6914	ELN-FBLN5-FBN1 complex	Human	None	HEK 293 cells	P15502;P35555;Q9UBX5	2006;2200;10516	MI:0071-molecular sieving;MI:0096-pull down	GO:0050436	microfibril binding	None	None	17255108	Fibulins 2 and Fibulin 5 can act as adaptors between Fibrillin-1 and (Tropo-) elastin.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Elastin;Fibrillin-1;Fibulin-5	ELN;FBN1;FBLN5	None;FBN;DANCE
6916	CTTN-FER-PTK2 complex	Human	None	Huh7 cells	P16591;Q05397;Q14247	2241;5747;2017	MI:0019-coimmunoprecipitation	GO:0022604	regulation of cell morphogenesis	None	None	19339212	Results suggest that Fer-mediated phosphorylation of specific FAK tyrosine residues may lead to membrane protrusions even in non-adherent conditions.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Tyrosine-protein kinase Fer;Focal adhesion kinase 1;Src substrate cortactin	FER;PTK2;CTTN	TYK3;FAK, FAK1;EMS1
6919	ILK-LIMS1-PARVA complex	Human	PIP complex; PINCH-1-ILK-alpha-parvin complex	human mesenchymal stem cells	P48059;Q13418;Q9NVD7	3987;3611;55742	MI:0019-coimmunoprecipitation	GO:0016477;GO:0006915;GO:0008360;GO:0007160	cell migration;apoptotic process;regulation of cell shape;cell-matrix adhesion	34.05.01;40.10.02;34.07.02	cell migration;apoptosis (type I programmed cell death);cell-matrix adhesion	20717960	The PINCH-1- integrin-linked kinase (ILK)- -parvin (PIP) complex plays important roles in the regulation of glomerular cell behavior, including podocyte shape change, apoptosis, and mesangial fibronectin matrix deposition.DEX partially stimulates hMSC migration by the expression of beta1-integrin through formation of a ILK-LIMS1/2-PARVA complex.	None	Experiments in mice (PMID: 18480182) have shown the existance of ILK-LIMS1-PARVA complex and ILK-LIMS2-PARVA complex.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	LIM and senescent cell antigen-like-containing domain protein 1;Integrin-linked protein kinase;Alpha-parvin	LIMS1;ILK;PARVA	PINCH PINCH1;ILK1 ILK2;MXRA2
6920	ILK-LIMS2-PARVA complex	Human	PIP complex; PINCH-2-ILK-alpha-parvin complex	human mesenchymal stem cells	Q13418;Q7Z4I7;Q9NVD7	3611;55679;55742	MI:0019-coimmunoprecipitation	GO:0016477;GO:0008360;GO:0007160	cell migration;regulation of cell shape;cell-matrix adhesion	34.05.01;34.07.02	cell migration;cell-matrix adhesion	20717960	Overexpression of PINCH-2 in mesangial cells resulted in displacement of PINCH-1 from the PIP complex but impaired neither mesangial cell spreading nor fibronectin matrix deposition.DEX partially stimulates hMSC migration by the expression of beta1-integrin through formation of a ILK-LIMS1/2-PARVA complex.	None	Experiments in mice (PMID: 18480182) have shown the existance of ILK-LIMS1-PARVA complex and ILK-LIMS2-PARVA complex with different functions.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin-linked protein kinase;LIM and senescent cell antigen-like-containing domain protein 2;Alpha-parvin	ILK;LIMS2;PARVA	ILK1 ILK2;PINCH2;MXRA2
6921	FAK\u2013p130Cas\u2013MT1 complex	Human	BCAR1-MMP14-PTK2 complex	293T cells; HT-1080 cells	P50281;P56945;Q05397	4323;9564;5747	MI:0007-anti tag coimmunoprecipitation	GO:0010715	regulation of extracellular matrix disassembly	None	None	22291036	Invasive matrix degradation at focal adhesions occurs via protease recruitment by the FAK-p130Cas-MT1 complex	Disruption of the FAK-p130Cas-MT1 complex impairs tumor cell invasion in vitro	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Matrix metalloproteinase-14;Breast cancer anti-estrogen resistance protein 1;Focal adhesion kinase 1	MMP14;BCAR1;PTK2	None;CAS CASS1 CRKAS;FAK, FAK1
6925	MAPK1-PTK2-PXN complex	Human	Paxillin-FAK-ERK complex	5637 bladder cancer cells	P28482;P49023;Q05397	5594;5829;5747	MI:0019-coimmunoprecipitation;MI:0416-fluorescence microscopy	GO:0016477;GO:0042060	cell migration;wound healing	34.05.01	cell migration	16849556	The growth factor proepithelin promotes paxillin activation and the formation of the MAPK3-PTK2-PXN complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mitogen-activated protein kinase 1;Paxillin;Focal adhesion kinase 1	MAPK1;PXN;PTK2	ERK2 PRKM1 PRKM2;None;FAK, FAK1
6927	Robo4\u2013paxillin complex	Human	PXN-ROBO4 complex	HEK 293 cells	P49023;Q8WZ75	5829;54538	MI:0019-coimmunoprecipitation	GO:2001212	regulation of vasculogenesis	None	None	19855388	Formation of a Robo4\u2013paxillin complex at the cell surface blocks activation of the small GTPase Arf6. Blocking Arf6 activity promotes vascular stability.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Paxillin;Roundabout homolog 4	PXN;ROBO4	None;None
6928	ARHGEF7-GIT2-PAK1 complex	Human	PKL-PIX-PAK1 complex	Jurkat cells	Q13153;Q14155;Q14161	5058;8874;9815	MI:0007-anti tag coimmunoprecipitation	GO:0050863;GO:0050852	regulation of T cell activation;T cell receptor signaling pathway	None	None	11157752	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein kinase PAK 1;Rho guanine nucleotide exchange factor 7;ARF GTPase-activating protein GIT2	PAK1;ARHGEF7;GIT2	None;COOL1 KIAA0142 P85SPR PAK3BP PIXB;KIAA0148
6929	AKT1-FOXO1-WDFY2 complex	Human	None	HEK293T cells	P31749;Q12778;Q96P53	207;2308;115825	MI:0007-anti tag coimmunoprecipitation	GO:1904179	positive regulation of adipose tissue development	None	None	18388859	WDFY2 binds Akt1 and Foxo1 and facilitates Foxo1 Ser253 phosphorylation by insulin-stimulated Akt1.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	RAC-alpha serine/threonine-protein kinase;Forkhead box protein O1;WD repeat and FYVE domain-containing protein 2	AKT1;FOXO1;WDFY2	PKB RAC;FKHR FOXO1A;WDF2,ZFYVE22
6930	PRKCZ-VAMP2-WDFY2 complex	Human	None	HEK 293T cells	P63027;Q05513;Q96P53	6844;5590;115825	MI:0007-anti tag coimmunoprecipitation;MI:0416-fluorescence microscopy	GO:0036465	synaptic vesicle recycling	20.09.07.29	vesicle recycling	17313651	The complex may be involved in vesicle cycling in various secretory pathways.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Vesicle-associated membrane protein 2;Protein kinase C zeta type;WD repeat and FYVE domain-containing protein 2	VAMP2;PRKCZ;WDFY2	SYB2;PKC2;WDF2,ZFYVE22
6931	FOXP3-TRIM28-ZFP90 complex	Human	FOXP3\u2013FIK\u2013KAP1 complex	HEK 293T cells	Q13263;Q8TF47;Q9BZS1	10155;146198;50943	MI:0019-coimmunoprecipitation	GO:0006338;GO:0045892	chromatin remodeling;negative regulation of DNA-templated transcription	11.02.03.04.03	transcription repression	23543754	In human regulatory T cells, a specific splice form of ZFP90 couples FOXP3 to a repressive chromatin-remodeling complex that includes the adaptor TRIM28.There is no sequence homologous with the unique C-terminal sequence of ZFP90 from the FOXP3-TRIM28-ZFP90 complex in the mouse genome.	FOXP3 mutations in humans with immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome, leads to the rapid onset of fatal autoimmune lymphoproliferative disease.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transcription intermediary factor 1-beta;Zinc finger protein 90 homolog;Forkhead box protein P3	TRIM28;ZFP90;FOXP3	KAP1 RNF96 TIF1B;KIAA1954,ZNF756;IPEX
6932	AJUBA-PRMT5-SNAI1 complex	Human	SNAIL-AJUBA-PRMT5 complex	HEK293 cells	O14744;O95863;Q96IF1	10419;6615;84962	MI:0007-anti tag coimmunoprecipitation;MI:0416-fluorescence microscopy	GO:0017053	transcription repressor complex	None	None	18347060	When AJUBA, SNAIL, and PRMT5 are coexpressed, a significant amount of the PRMT5 protein is relocated to the nucleus and colocalizes with nuclear SNAIL and AJUBA.The AJUBA-PRMT5-SNAI1 complex binds to the endogenous promoter of E-cadherin and downregulates  E-cadherin gene expression.	None	The AJUBA protein functions as an adaptor to bridge SNAIL and PRMT5 proteins.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein arginine N-methyltransferase 5;Zinc finger protein SNAI1;LIM domain-containing protein ajuba	PRMT5;SNAI1;AJUBA	HRMT1L5 IBP72 JBP1 SKB1;SNAH;JUB
6933	PRKCZ-SQSTM-TRAF6 complex	Human	aPKC-p62-TRAF6 complex	HepG2 cells; HEK293 cells	Q05513;Q13501;Q9Y4K3	5590;8878;7189	MI:0019-coimmunoprecipitation	GO:1901222	regulation of NIK/NF-kappaB signaling	None	None	15870274	Results provide evidence indicating that Ajuba is a new cytosolic component of the IL-1 signaling pathway modulating IL-1-induced NFkappaB activation by influencing the assembly and activity of the PRKCZ-SQSTM-TRAF6 signaling complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein kinase C zeta type;Sequestosome-1;TNF receptor-associated factor 6	PRKCZ;SQSTM1;TRAF6	PKC2;ORCA OSIL;RNF85
6935	MYC-TRRAP-KAT2A complex	Human	c-Myc-TRRAP-GCN5 complex	293 cell lysates	P01106;Q92830;Q9Y4A5	4609;2648;8295	MI:0019-coimmunoprecipitation	GO:0006338;GO:0016573;GO:0006351	chromatin remodeling;histone acetylation;DNA-templated transcription	11	TRANSCRIPTION	10611234	TRRAP and hGCN5 are contained in a complex which associates withthe c-Myc N terminus in vivo and after in vitro reconstitution.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Myc proto-oncogene protein;Histone acetyltransferase KAT2A;Transformation/transcription domain-associated protein	MYC;KAT2A;TRRAP	BHLHE39;GCN5 GCN5L2;PAF400
6936	KAT2A-TRRAP complex	Human	hGCN5-TRRAP complex	293 cell lysates	Q92830;Q9Y4A5	2648;8295	MI:0019-coimmunoprecipitation	GO:0016573;GO:0006351	histone acetylation;DNA-templated transcription	11	TRANSCRIPTION	10611234	hGCN5 (KAT2A) and TRRAP preexist in a complex in mammalian cells. Their interaction does not require c-Myc, and only a small fraction of the hGCN5-TRRAP complexcontains c-Myc.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Histone acetyltransferase KAT2A;Transformation/transcription domain-associated protein	KAT2A;TRRAP	GCN5 GCN5L2;PAF400
6937	ARHGEF2-MAPK1-MAPK3-PXN complex	Human	Paxillin-p42/44MAPK-GEF-H1 complex	Human lung endothelial cells	P27361;P28482;P49023;Q92974	5595;5594;5829;9181	MI:0019-coimmunoprecipitation	GO:0035025;GO:0043114	positive regulation of Rho protein signal transduction;regulation of vascular permeability	None	None	24706358	Cyclic stretches in lung cells induce functional interactions between paxillin, p42/44 MAPK, and GEF-H1.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mitogen-activated protein kinase 3;Mitogen-activated protein kinase 1;Paxillin;Rho guanine nucleotide exchange factor 2	MAPK3;MAPK1;PXN;ARHGEF2	ERK1 PRKM3;ERK2 PRKM1 PRKM2;None;KIAA0651 LFP40
6939	Norrin receptor complex	Human	FZD4-LRP5-NDP-TSPAN12 complex	HEK 293 cells	O75197;O95859;Q00604;Q9ULV1	4041;23554;4693;8322	MI:0007-anti tag coimmunoprecipitation;MI:0040-electron microscopy	GO:0007166;GO:0005886	cell surface receptor signaling pathway;plasma membrane	30.05;70.02	transmembrane signal transduction;eukaryotic plasma membrane / membrane attached	19837033	Overexpressed TSPAN12 associates with the Norrin-receptor complex and significantly increases Norrin/beta-catenin but not Wnt/beta-catenin signaling.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Low-density lipoprotein receptor-related protein 5;Tetraspanin-12;Norrin;Frizzled-4	LRP5;TSPAN12;NDP;FZD4	LR3 LRP7;NET2,TM4SF12;EVR2;None
6940	LRP6-PTH-PTH1R complex	Human	None	HEK293 cells	O75581;P01270;Q03431	4040;5741;5745	MI:0019-coimmunoprecipitation;MI:0055-fluorescent resonance energy transfer	GO:1905114;GO:0005886	cell surface receptor signaling pathway involved in cell-cell signaling;plasma membrane	70.02	eukaryotic plasma membrane / membrane attached	18981475	The authors found that PTH activates  beta-catenin signaling in osteoblasts both in vitro and in vivo by sharing of a coreceptor with Wnt; however, PTH signal acts in a distinct manner from that of the canonical Wnt signaling pathway in that LRP6 forms a complex with PTH and PTH1R. The ternary complex promoted phosphorylation of LRP6, which recruits axin from the cytoplasma, and induces  beta-catenin stabilization.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Low-density lipoprotein receptor-related protein 6;Parathyroid hormone;Parathyroid hormone/parathyroid hormone-related peptide receptor	LRP6;PTH;PTH1R	None;None;PTHR PTHR1
6942	FZD5-LGR5-LRP6 complex	Human	None	HEK293 cells	O75473;O75581;Q13467	8549;4040;7855	MI:0019-coimmunoprecipitation;MI:0055-fluorescent resonance energy transfer	GO:0030177;GO:0005886	positive regulation of Wnt signaling pathway;plasma membrane	70.02	eukaryotic plasma membrane / membrane attached	22473993	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Leucine-rich repeat-containing G-protein coupled receptor 5;Low-density lipoprotein receptor-related protein 6;Frizzled-5	LGR5;LRP6;FZD5	GPR49 GPR67;None;C2orf31
6946	BARD1\u2013BRCA1\u2013RAD51 complex	Human	BRCA1\u2013BARD1\u2013RAD51 complex	HeLa cells	P38398;Q06609;Q99728	672;5888;580	MI:0019-coimmunoprecipitation	GO:0006281;GO:0042148;GO:0035825	DNA repair;strand invasion;homologous recombination	10.01.05.01	DNA repair	28976962	Experiments establish the biological importance of the BRCA1\u2013BARD1\u2013RAD51 complex in DNA damage repair via homologous recombination and provide cellular evidence for a role of BRCA1\u2013BARD1 in the DNA strand invasion step of homologous recombination.	One mutation (K140N) in BARD1, found in two patients with colorectal adenocarcinoma, attenuated the affinity of BRCA1\u2013BARD1 for RAD51 and also compromised the ability of the tumour suppressor complex to enhance D-loop formation and synaptic complex assembly.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Breast cancer type 1 susceptibility protein;DNA repair protein RAD51 homolog 1;BRCA1-associated RING domain protein 1	BRCA1;RAD51;BARD1	RNF53;RAD51A RECA;None
6948	Isocitrate dehydrogenase [NADP], mitochondrial	Human	IDH2 homodimer	HEK-293T, MCF7 cells	P48735	3418	MI:0019-coimmunoprecipitation	GO:0005739;GO:0006102	mitochondrion;isocitrate metabolic process	70.16	mitochondrion	28536275	The results show that loss of SIRT3 increases acetylation of IDH2 at lysine 413 (IDH2-K413-Ac), thereby decreasing its enzymatic activity by reducing IDH2 dimer formation.	Metabolically, expression of IDH2 (K413Q) alters cancer cell metabolism and results in accumulation of ROS.	None	Homo sapiens (Human)	Isocitrate dehydrogenase [NADP], mitochondrial	IDH2	None
6949	Isocitrate dehydrogenase [NAD], mitochondrial	Human	Isocitrate dehydrogenase [NAD] (alpha2-beta-gamma), mitochondrial; IDH3A(2)-IDH3B-IDH3G heterotetramer	None	O43837;P50213;P51553	3420;3419;3421	MI:0004-affinity chromatography technology;MI:0071-molecular sieving	GO:0006102;GO:0051287;GO:0005739;GO:0046872;GO:0006099	isocitrate metabolic process;NAD binding;mitochondrion;metal ion binding;tricarboxylic acid cycle	16.21.07;70.16;16.17;02.10	NAD/NADP binding;mitochondrion;metal binding;tricarboxylic-acid pathway (citrate cycle, Krebs cycle, TCA cycle)	28139779	The allosteric regulation of the alpha-2-beta-gamma heterotetramer is through the gamma subunit not the beta subunit.The gamma subunit plays the regulatory role to activate the holoenzyme, and the beta subunit the structural role to facilitate the assembly of the holoenzyme.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial;Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial;Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial	IDH3B;IDH3A;IDH3G	None;None;None
6951	NG2-galectin-3-alpha3beta1-integrin complex	Human	CSPG4-LGALS3-ITGA3-ITGB1 complex	Human dermal microvascular endothelial cells	P05556;P17931;P26006;Q6UVK1	3688;3958;3675;1464	MI:0096-pull down	GO:0045765	regulation of angiogenesis	None	None	15181153	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-1;Galectin-3;Integrin alpha-3;Chondroitin sulfate proteoglycan 4	ITGB1;LGALS3;ITGA3;CSPG4	FNRB, MDF2, MSK12;MAC2;MSK18;MCSP
6953	ARTN-GFRA3-RET comples	Human	None	None	O60609;P07949;Q5T4W7	2676;5979;9048	MI:0001-interaction detection method	GO:0007399	nervous system development	47.03.01	nervous system	9883723	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	GDNF family receptor alpha-3;Proto-oncogene tyrosine-protein kinase receptor Ret;Artemin	GFRA3;RET;ARTN	None;CDHF12 CDHR16 PTC RET51;EVN
6954	Idas-Geminin-Cdt1 complex	Human	None	None	D6RGH6;O75496;Q9H211	345643;51053;81620	MI:0107-surface plasmon resonance	GO:0006275	regulation of DNA replication	None	None	24064211	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Multicilin;Geminin;DNA replication factor Cdt1	MCIDAS;GMNN;CDT1	IDAS,MCI,MCIN;None;None
6956	REP-RGGT-Rab complex	Human	None	None	P20336;P24386;Q92696	5864;1121;5875	MI:0029-cosedimentation through density gradient;MI:0096-pull down	GO:2000539	regulation of protein geranylgeranylation	None	None	18532927	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Ras-related protein Rab-3A;Rab proteins geranylgeranyltransferase component A 1;Geranylgeranyl transferase type-2 subunit alpha	RAB3A;CHM;RABGGTA	None;REP1 TCD;None
6957	C2ORF3-Prp43-TFIP11 complex	Human	None	None	O43143;P16383;Q9UBB9	1665;6936;None	MI:0019-coimmunoprecipitation	GO:0000381	regulation of alternative mRNA splicing, via spliceosome	None	None	24304693	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	ATP-dependent RNA helicase DHX15;Intron Large complex component GCFC2;Tuftelin-interacting protein 11	DHX15;GCFC2;TFIP11	DBP1 DDX15;C2orf3 GCF TCF9;STIP
6958	BOLA2-GLRX3 complex	Human	None	BL21(DE3) cells	O76003;Q9H3K6	10539;107984053	MI:0029-cosedimentation through density gradient	GO:0055072	iron ion homeostasis	None	None	22309771	Results suggest that the BOLA2-GLRX3 complex is conserved in higher eukaryotes and may play a role in signaling cellular iron status in humans.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Glutaredoxin-3;BolA-like protein 2	GLRX3;BOLA2	PICOT,TXNL2;BOLA2A
6959	GATB-GATC-QRSL1 complex	Human	GATBA-GATB-GATC complex; GatCAB	HeLa cells	O43716;O75879;Q9H0R6	283459;5188;55278	MI:0071-molecular sieving;MI:0257-antisense rna	GO:0006424;GO:0005739;GO:0070681	glutamyl-tRNA aminoacylation;mitochondrion;glutaminyl-tRNAGln biosynthesis via transamidation	70.16	mitochondrion	19805282	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial;Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial;Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial	GATC;GATB;QRSL1	15E1.2;PET112 PET112L;None
6960	BICD2-dynein-dynactin complex	Human	None	in vitro	O14576;Q14203;Q8TD16	1780;1639;23299	MI:0096-pull down	GO:0060236	regulation of mitotic spindle organization	None	None	28883039	None	None	Disease-related point mutations in BICD2 increase binding to dynein/dynactin and motility (PMID: 28883039).	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cytoplasmic dynein 1 intermediate chain 1;Dynactin subunit 1;Protein bicaudal D homolog 2	DYNC1I1;DCTN1;BICD2	DNCI1 DNCIC1;None;KIAA0699
6961	CTNNB1-GID8 complex	Human	None	HEK-293 cells	P35222;Q9NWU2	1499;54994	MI:0019-coimmunoprecipitation	GO:0005634;GO:0060070	nucleus;canonical Wnt signaling pathway	70.10	nucleus	28829046	GID8 (TWA1) is a regulator of the Wnt pathway promoting colorectal tumorigenesis by facilitating beta-catenin nuclear retention.	GID8 (TWA1) is significantly upregulated in human CRC tissues and correlates with a poor prognosis for CRC patients.	None	Homo sapiens (Human);Homo sapiens (Human)	Catenin beta-1;Glucose-induced degradation protein 8 homolog	CTNNB1;GID8	CTNNB;C20orf11 TWA1
6963	AXIN1-GID8-GSK3B complex	Human	None	HEK-293 cells	O15169;P49841;Q9NWU2	8312;2932;54994	MI:0019-coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0060070;GO:0005737	canonical Wnt signaling pathway;cytoplasm	70.03	cytoplasm	28829046	GID8 (TWA1) is a regulator of the Wnt pathway promoting colorectal tumorigenesis by facilitating beta-catenin nuclear retention.Data indicate that in the absence of Wnt signal, GID8 is targeted by the Axin complex for ubiquitination and degradation.	GID8 (TWA1) is significantly upregulated in human CRC tissues and correlates with a poor prognosis for CRC patients.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Axin-1;Glycogen synthase kinase-3 beta;Glucose-induced degradation protein 8 homolog	AXIN1;GSK3B;GID8	AXIN;None;C20orf11 TWA1
6968	Serine-palmitoyltransferase (SPTLC1, SPTLC2) complex	Human	LCB1-LCB2 complex; SPT complex	Hek293 cells; HepG2 cells	O15269;O15270	10558;9517	MI:0400-affinity technology	GO:0005783;GO:0016409;GO:0002178;GO:0030148	endoplasmic reticulum;palmitoyltransferase activity;palmitoyltransferase complex;sphingolipid biosynthetic process	70.07	endoplasmic reticulum	17023427	Serine-palmitoyltransferase (SPT) catalyzes the rate-limiting step of the de novo synthesis of sphingolipids.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Serine palmitoyltransferase 1;Serine palmitoyltransferase 2	SPTLC1;SPTLC2	LCB1;KIAA0526 LCB2
6969	Serine-palmitoyltransferase (SPTLC1, SPTLC2, SPTLC3) complex	Human	LCB1-LCB2-SPTLC2L complex; SPT complex	HEK-293 cells; human placenta extract	O15269;O15270;Q9NUV7	10558;9517;55304	MI:0091-chromatography technology;MI:0096-pull down;MI:0276-blue native page	GO:0005783;GO:0016409;GO:0002178;GO:0030148	endoplasmic reticulum;palmitoyltransferase activity;palmitoyltransferase complex;sphingolipid biosynthetic process	70.07	endoplasmic reticulum	17331073	SPT (serine palmitoyltransferase) catalyses the rate-limiting step for the de novo synthesis of sphingolipids. It is concluded that the functional SPT is not a dimer, but a higher organized complex, composed of three distinct subunits (SPTLC1, SPTLC2 and SPTLC3) with a molecular mass of 480 kDa. The stoichiometry of SPTLC2 and SPTLC3 seems not to be fixed and is probably changed dynamically in dependence of the tissue specific SPTLC2 and SPTLC3 expression levels. A model of an octameric SPT structure is proposed.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Serine palmitoyltransferase 1;Serine palmitoyltransferase 2;Serine palmitoyltransferase 3	SPTLC1;SPTLC2;SPTLC3	LCB1;KIAA0526 LCB2;C20orf38 SPTLC2L
6970	Serine-palmitoyltransferase (SPTLC1, SPTLC3, ssSPTb) complex	Human	hLCB1-hLCB2b-ssSPTb isozyme; SPT complex	yeast microsomes expressing human SPT subunits	O15269;Q8NFR3;Q9NUV7	10558;165679;55304	MI:0018-two hybrid;MI:0047-far western blotting	GO:0005783;GO:0016409;GO:0002178;GO:0030148	endoplasmic reticulum;palmitoyltransferase activity;palmitoyltransferase complex;sphingolipid biosynthetic process	70.07	endoplasmic reticulum	19416851	Serine palmitoyltransferase (SPT) catalyzes the first committed step in sphingolipid biosynthesis. The two small subunit isoforms of SPT, ssSPTa and ssSPTb, share a conserved hydrophobic central domain predicted to reside in the membrane, and each interacts with both hLCB1 and hLCB2. The resulting four SPT isozymes have distinct Acyl-CoA preferences and synthesize different LCBs ( long-chain bases). The most active and selective isozyme was hLCB1-hLCB2a-ssSPTa showing a strong preference for C16-CoA . The hLCB1-hLCB2b-ssSPTa isozyme used C14-CoA as well. The hLCB1-hLCB2a-ssSPTb enzyme showed a clear preference for C18-CoA, whereas the hLCB1-hLCB2b-ssSPTb multimer displayed an ability to use a broader range of acyl-CoAs, without apparent preference. Isozymes containing the ssSPTb subunit preferred longer acyl-CoAs.	HSAN1 (Hereditary sensory autonomic neuropathy 1) is the result of dominant mutations in hLCB1.It has been presumed that these mutations lead to a 50%  decrease in SPT activity in all tissues.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Serine palmitoyltransferase 1;Serine palmitoyltransferase small subunit B;Serine palmitoyltransferase 3	SPTLC1;SPTSSB;SPTLC3	LCB1;ADMP C3orf57 SSSPTB;C20orf38 SPTLC2L
6972	Serine-palmitoyltransferase (SPTLC1, SPTLC3, ssSPTa) complex	Human	hLCB1-hLCB2b-ssSPTa isozyme; SPT complex	yeast microsomes expressing human SPT subunits	O15269;Q969W0;Q9NUV7	10558;171546;55304	MI:0018-two hybrid;MI:0047-far western blotting	GO:0005783;GO:0016409;GO:0002178;GO:0030148	endoplasmic reticulum;palmitoyltransferase activity;palmitoyltransferase complex;sphingolipid biosynthetic process	70.07	endoplasmic reticulum	19416851	Serine palmitoyltransferase (SPT) catalyzes the first committed step in sphingolipid biosynthesis. The two small subunit isoforms of SPT, ssSPTa and ssSPTb, share a conserved hydrophobic central domain predicted to reside in the membrane, and each interacts with both hLCB1 and hLCB2. The resulting four SPT isozymes have distinct Acyl-CoA preferences and synthesize different LCBs ( long-chain bases). The most active and selective isozyme was hLCB1-hLCB2a-ssSPTa showing a strong preference for C16-CoA . The hLCB1-hLCB2b-ssSPTa isozyme used C14-CoA as well. The hLCB1-hLCB2a-ssSPTb enzyme showed a clear preference for C18-CoA, whereas the hLCB1-hLCB2b-ssSPTb multimer displayed an ability to use a broader range of acyl-CoAs, without apparent preference. Isozymes containing the ssSPTb subunit preferred longer acyl-CoAs.	HSAN1 (Hereditary sensory autonomic neuropathy 1) is the result of dominant mutations in hLCB1.It has been presumed that these mutations lead to a 50% decrease in SPT activity in all tissues.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Serine palmitoyltransferase 1;Serine palmitoyltransferase small subunit A;Serine palmitoyltransferase 3	SPTLC1;SPTSSA;SPTLC3	LCB1;C14orf147 SSSPTA;C20orf38 SPTLC2L
6973	Serine-palmitoyltransferase (SPTLC1, SPTLC2, ssSPTb) complex	Human	hLCB1-hLCB2a-ssSPTb isozyme; SPT complex	yeast microsomes expressing human SPT subunits	O15269;O15270;Q8NFR3	10558;9517;165679	MI:0018-two hybrid;MI:0047-far western blotting	GO:0005783;GO:0016409;GO:0002178;GO:0030148	endoplasmic reticulum;palmitoyltransferase activity;palmitoyltransferase complex;sphingolipid biosynthetic process	70.07	endoplasmic reticulum	19416851	Serine palmitoyltransferase (SPT) catalyzes the first committed step in sphingolipid biosynthesis. The two small subunit isoforms of SPT, ssSPTa and ssSPTb, share a conserved hydrophobic central domain predicted to reside in the membrane, and each interacts with both hLCB1 and hLCB2. The resulting four SPT isozymes have distinct Acyl-CoA preferences and synthesize different LCBs ( long-chain bases). The most active and selective isozyme was hLCB1-hLCB2a-ssSPTa showing a strong preference for C16-CoA . The hLCB1-hLCB2b-ssSPTa isozyme used C14-CoA as well. The hLCB1-hLCB2a-ssSPTb enzyme showed a clear preference for C18-CoA, whereas the hLCB1-hLCB2b-ssSPTb multimer displayed an ability to use a broader range of acyl-CoAs, without apparent preference. Isozymes containing the ssSPTb subunit preferred longer acyl-CoAs.	HSAN1 (Hereditary sensory autonomic neuropathy 1) is the result of dominant mutations in hLCB1.It has been presumed that these mutations lead to a 50% decrease in SPT activity in all tissues.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Serine palmitoyltransferase 1;Serine palmitoyltransferase 2;Serine palmitoyltransferase small subunit B	SPTLC1;SPTLC2;SPTSSB	LCB1;KIAA0526 LCB2;ADMP C3orf57 SSSPTB
6974	Serine-palmitoyltransferase (SPTLC1, SPTLC2, ssSPTa) complex	Human	hLCB1-hLCB2a-ssSPTa isozyme; SPT complex	yeast microsomes expressing human SPT subunits	O15269;O15270;Q969W0	10558;9517;171546	MI:0018-two hybrid;MI:0047-far western blotting	GO:0005783;GO:0016409;GO:0002178;GO:0030148	endoplasmic reticulum;palmitoyltransferase activity;palmitoyltransferase complex;sphingolipid biosynthetic process	70.07	endoplasmic reticulum	19416851	Serine palmitoyltransferase (SPT) catalyzes the first committed step in sphingolipid biosynthesis. The two small subunit isoforms of SPT, ssSPTa and ssSPTb, share a conserved hydrophobic central domain predicted to reside in the membrane, and each interacts with both hLCB1 and hLCB2. The resulting four SPT isozymes have distinct Acyl-CoA preferences and synthesize different LCBs ( long-chain bases). The most active and selective isozyme was hLCB1-hLCB2a-ssSPTa showing a strong preference for C16-CoA . The hLCB1-hLCB2b-ssSPTa isozyme used C14-CoA as well. The hLCB1-hLCB2a-ssSPTb enzyme showed a clear preference for C18-CoA, whereas the hLCB1-hLCB2b-ssSPTb multimer displayed an ability to use a broader range of acyl-CoAs, without apparent preference. Isozymes containing the ssSPTb subunit preferred longer acyl-CoAs.	HSAN1 (Hereditary sensory autonomic neuropathy 1)  is the result of dominant mutations in hLCB1.It has been presumed that these mutations lead to a 50% decrease in SPT activity in all tissues.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Serine palmitoyltransferase 1;Serine palmitoyltransferase 2;Serine palmitoyltransferase small subunit A	SPTLC1;SPTLC2;SPTSSA	LCB1;KIAA0526 LCB2;C14orf147 SSSPTA
6975	JUN-FBW7-PRR7 complex	Human	None	HEK293 cells	P05412;Q8TB68;Q969H0	3725;80758;55294	MI:0096-pull down	GO:0043506	regulation of JUN kinase activity	None	None	27458189	PRR7 inhibits the ubiquitination of c-Jun by FBW7. This increases c-Jun-dependent transcriptional activity and promotes neuronal death.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transcription factor Jun;Proline-rich protein 7;F-box/WD repeat-containing protein 7	JUN;PRR7;FBXW7	None;None;FBW7 FBX30 SEL10
6980	IGF1-IGF1R-ITGAV-ITGB3 complex	Human	(Integrin alpha-V/beta-3)-IGF1R-IGF1 complex	CHO cells expressing human genes	P05019;P05106;P06756;P08069	3479;3690;3685;3480	MI:0019-coimmunoprecipitation	GO:0048009;GO:0016049	insulin-like growth factor receptor signaling pathway;cell growth	30.05.01.12.04;40.01	IGF-receptor signalling pathway;cell growth / morphogenesis	23243309	Integrin alphaV-beta3 plays a role in IGF signaling through direct binding to IGF1 and subsequent complex formation (AlphaVBeta3-IGF1-IGF1R). AlphaVbeta3-ECM interaction is not required for IGF signaling. The complex formation occurs before IGF1R activation.	IGF1 has been implicated in cancer progression.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Insulin-like growth factor I;Integrin beta-3;Integrin alpha-V;Insulin-like growth factor 1 receptor	IGF1;ITGB3;ITGAV;IGF1R	IBP1;GP3A;MSK8 VNRA VTNR;None
6982	ORMDL3-SPTLC1 complex	Human	None	HEK293T cells; HeLa cells	O15269;Q8N138	10558;94103	MI:0019-coimmunoprecipitation;MI:0069-mass spectrometry studies of complexes	GO:0090155	negative regulation of sphingolipid biosynthetic process	None	None	20182505	Orm proteins as negative regulators of sphingolipid synthesis form a conserved complex with serine palmitoyltransferase, the first and rate-limiting enzyme in sphingolipid production. Phosphorylation of Orm proteins relieves their inhibitory activity when sphingolipid production is disrupted. Changes in ORM gene expression or mutations to their phosphorylation sites cause dysregulation of sphingolipid metabolism. The authors describe the SPOTS complex (= Serine-palmitoyltransferase LBC1/2)-(ORMDL1/2)-TSC3-SAC1 complex) in S.cerevisiae and conclude via analysis in human cells (mass spectrometry, immunoprecipitations) that the yeast functional complex between Orm proteins (= ORMDL in humans) and serine palmitoyltransferase is also conserved in human cells.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Serine palmitoyltransferase 1;ORM1-like protein 3	SPTLC1;ORMDL3	LCB1;None
6984	ProTalpha C2 complex	Human	PTMA-SET-ACTB-MARCKS complex	proliferating FT Jukart cells	P06454;P49006;P60709;Q01105	5757;65108;60;6418	MI:0030-cross-linking study;MI:0069-mass spectrometry studies of complexes	GO:0043066;GO:0008283	negative regulation of apoptotic process;cell population proliferation	40.10.02.01	anti-apoptosis	29106904	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Prothymosin alpha;MARCKS-related protein;Actin, cytoplasmic 1;Protein SET	PTMA;MARCKSL1;ACTB;SET	TMSA;MLP MRP;None;None
6985	ProTalpha C5 complex	Human	ANP32A-C1QB-PSMA1-PTMA-SLC25A3 complex	FT Jurkat cells	P06454;P25786;P39687;Q00325;Q07021	5757;5682;8125;5250;708	MI:0069-mass spectrometry studies of complexes	GO:0004306	ethanolamine-phosphate cytidylyltransferase activity	None	None	29106904	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Prothymosin alpha;Proteasome subunit alpha type-1;Acidic leucine-rich nuclear phosphoprotein 32 family member A;Phosphate carrier protein, mitochondrial;Complement component 1 Q subcomponent-binding protein, mitochondrial	PTMA;PSMA1;ANP32A;SLC25A3;C1QBP	TMSA;HC2 NU PROS30 PSC2;C15orf1 LANP MAPM PHAP1;PHC;GC1QBP HABP1 SF2P32
6987	ProTalpha C7 complex	Human	PTMA-ANP32A-ANP32B complex	proliferating FT Jurkat cells	P06454;P39687;Q92688	5757;8125;10541	MI:0030-cross-linking study;MI:0069-mass spectrometry studies of complexes	GO:0043066;GO:0008283	negative regulation of apoptotic process;cell population proliferation	40.10.02.01	anti-apoptosis	29106904	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Prothymosin alpha;Acidic leucine-rich nuclear phosphoprotein 32 family member A;Acidic leucine-rich nuclear phosphoprotein 32 family member B	PTMA;ANP32A;ANP32B	TMSA;C15orf1 LANP MAPM PHAP1;APRIL,PHAPI2
6988	ProTalpha C8 complex	Human	PTMA-ANP32A-ANP32B-RAB11A complex	proliferating FT Jurkat cells	P06454;P39687;P62491;Q92688	5757;8125;8766;10541	MI:0030-cross-linking study;MI:0069-mass spectrometry studies of complexes	GO:0043066;GO:0008283	negative regulation of apoptotic process;cell population proliferation	40.10.02.01	anti-apoptosis	29106904	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Prothymosin alpha;Acidic leucine-rich nuclear phosphoprotein 32 family member A;Ras-related protein Rab-11A;Acidic leucine-rich nuclear phosphoprotein 32 family member B	PTMA;ANP32A;RAB11A;ANP32B	TMSA;C15orf1 LANP MAPM PHAP1;RAB11;APRIL,PHAPI2
6989	ProTalpha C9 complex	Human	PTMA-SET complex	FT Jurkat cells	P06454;Q01105	5757;6418	MI:0030-cross-linking study;MI:0069-mass spectrometry studies of complexes	GO:0043066;GO:0008283	negative regulation of apoptotic process;cell population proliferation	40.10.02.01	anti-apoptosis	29106904	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Prothymosin alpha;Protein SET	PTMA;SET	TMSA;None
6990	THSD1-FAK-talin-vinculin complex	Human	THSD1-PTK2-TLN1-VCL complex	HEK293T cells	P18206;Q05397;Q9NS62;Q9Y490	7414;5747;55901;7094	MI:0019-coimmunoprecipitation	GO:0051893	regulation of focal adhesion assembly	None	None	29069646	None	The harmful variants in THSD1 (Thrombospondin type-1 domain-containing protein 1) likely cause intracranial aneurysm and subarachnoid hemorrhage in a subset of both familial and sporadic patients with supporting evidence from two vertebrate models (PMID:29069646).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Vinculin;Focal adhesion kinase 1;Thrombospondin type-1 domain-containing protein 1;Talin-1	VCL;PTK2;THSD1;TLN1	None;FAK, FAK1;TMTSP;KIAA1027 TLN
6991	ABI3-WAVE2-CYFIP1 complex	Human	None	WRO and FTC133 cells	Q7L576;Q9P2A4;Q9Y6W5	23191;51225;10163	MI:0019-coimmunoprecipitation	GO:0014066	regulation of phosphatidylinositol 3-kinase signaling	None	None	28978070	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cytoplasmic FMR1-interacting protein 1;ABI gene family member 3;Actin-binding protein WASF2	CYFIP1;ABI3;WASF2	KIAA0068;NESH;WAVE2
6993	FGF1-ITGAV-ITGB3 complex	Human	AlphaV-Beta3-FGF1 complex	K562 cells	P05106;P05230;P06756	3690;2246;3685	MI:0678-antibody array	GO:0008543	fibroblast growth factor receptor signaling pathway	30.05.01.12.03	FGF-receptor signalling pathway	18441324	The direct binding of FGF1 to soluble and cell-surface integrin alphavbeta3 (= ITGAV-ITGB3) plays a role in FGF1 signaling. An FGF1 mutant (R50E) was identified that was defective in integrin binding but still bound to heparin and FGFR. R50E was defective in inducing DNA synthesis, cell proliferation, cell migration, and chemotaxis, suggesting that the direct integrin binding to FGF1 is critical for FGF signaling.	FGF1 and FGF2 are responsible for resistance to chemotherapeuticagents in cancer and are also pro-inflammatory growth factors that play a role in pathological angiogenesis in chronic inflammatory diseases.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-3;Fibroblast growth factor 1;Integrin alpha-V	ITGB3;FGF1;ITGAV	GP3A;FGFA;MSK8 VNRA VTNR
6994	JIP1-JIP2 complex	Human	None	HEK293 cells	Q13387;Q9UQF2	23542;9479	MI:0019-coimmunoprecipitation	GO:0061880	regulation of anterograde axonal transport of mitochondrion	None	None	28638935	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	C-Jun-amino-terminal kinase-interacting protein 2;C-Jun-amino-terminal kinase-interacting protein 1	MAPK8IP2;MAPK8IP1	IB2 JIP2 PRKM8IPL;IB1 JIP1 PRKM8IP
6997	ADIPOQ-GLT25D1-PLOD3 complex	Human	None	HEK cells	O60568;Q15848;Q8NBJ5	8985;9370;79709	MI:0019-coimmunoprecipitation;MI:0069-mass spectrometry studies of complexes	GO:0032368	regulation of lipid transport	None	None	28428430	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3;Adiponectin;Procollagen galactosyltransferase 1	PLOD3;ADIPOQ;COLGALT1	None;ACDC ACRP30 APM1 GBP28;GLT25D1
6998	ST3GAL6-EGFR complex	Human	None	None	P00533;Q9Y274	1956;10402	MI:0019-coimmunoprecipitation	GO:0030334	regulation of cell migration	None	None	28423672	None	OMIM:167000 Ovarian Cancer, Epithelial (PMID:28423672).	None	Homo sapiens (Human);Homo sapiens (Human)	Epidermal growth factor receptor;Type 2 lactosamine alpha-2,3-sialyltransferase	EGFR;ST3GAL6	ERBB ERBB1 HER1;SIAT10
6999	SEPHS1-SEPHS2-SEPSECS-SECp43 complex	Human	None	None	P49903;Q99611;Q9HD40;Q9NX07	22929;22928;51091;54952	MI:0019-coimmunoprecipitation	GO:0001514;GO:0016259	selenocysteine incorporation;selenocysteine metabolic process	12.11	selenocystein biosynthesis and incorporation	28414460	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Selenide, water dikinase 1;Selenide, water dikinase 2;O-phosphoseryl-tRNA(Sec) selenium transferase;tRNA selenocysteine 1-associated protein 1	SEPHS1;SEPHS2;SEPSECS;TRNAU1AP	SELD SPS SPS1;SPS2;TRNP48;SECP43,TRSPAP1
7000	PLOD2-FKBP10 complex	Human	None	None	O00469;Q96AY3	5352;60681	MI:0019-coimmunoprecipitation	GO:0030199	collagen fibril organization	None	None	28378777	FKBP65-dependent peptidyl-prolyl isomerase domain/activity is responsible for its interaction with LH2 and ultimately to regulate the formation of LH2-mediated collagen cross-links.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2;Peptidyl-prolyl cis-trans isomerase FKBP10	PLOD2;FKBP10	None;FKBP65
7002	CAPZA3-CAPZB complex	Human	CPalpha3-CPbeta3 complex	None	P47756;Q96KX2	832;93661	MI:0019-coimmunoprecipitation	GO:0007283	spermatogenesis	None	None	28104696	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	F-actin-capping protein subunit beta;F-actin-capping protein subunit alpha-3	CAPZB;CAPZA3	None;CAPAA3 GSG3
7004	HTT-DISC1-PDE4B complex	Human	None	brain	P42858;Q07343;Q9NRI5	3064;5142;27185	MI:0019-coimmunoprecipitation	None	None	None	None	28263187	None	OMIM:143100 Huntington disease (PMID:28263187).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Huntingtin;cAMP-specific 3',5'-cyclic phosphodiesterase 4B;Disrupted in schizophrenia 1 protein	HTT;PDE4B;DISC1	HD IT15;DPDE4;KIAA0457
7005	PP2A-NR3A complex	Human	Protein phosphatase 2A-NMDA receptor signaling complex	HEK293 cells	P30153;P63151;P67775;Q8TCU5	5518;5520;5515;116443	MI:0006-anti bait coimmunoprecipitation	GO:0048167;GO:0043666	regulation of synaptic plasticity;regulation of phosphoprotein phosphatase activity	None	None	11588171	None	None	Since the authors did not specify A and C subunit of the PP2A complex, we used isoform  PPP2R1A and PPP2CA.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform;Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform;Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform;Glutamate receptor ionotropic, NMDA 3A	PPP2R1A;PPP2R2A;PPP2CA;GRIN3A	None;None;None;KIAA1973
7011	FERMT3-RACK1 complex	Human	KIND3-RACK1 complex	SKW3 human T lymphoma cells; 293T cells	P63244;Q86UX7	10399;83706	MI:0019-coimmunoprecipitation	GO:0034687;GO:0097110;GO:0007229	integrin alphaL-beta2 complex;scaffold protein binding;integrin-mediated signaling pathway	30.05.02.26	integrin receptor signalling pathway	22334666	Kindlin-3 (= FERMT3) is involved in integrin alphaLbeta2 outside-in signaling, induces integrin alphaLbeta2 clustering, and interacts with the scaffold protein, the receptor for activated-C kinase 1, RACK1. This interaction involves the pleckstrin homology domain of kindlin-3 and blades 5\u20137 of RACK1. It is show that integrin alphaLbeta2 engagement by its ligand ICAM-1 promotes the association of kindlin-3 with RACK1.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Receptor of activated protein C kinase 1;Fermitin family homolog 3	RACK1;FERMT3	GNB2L1;KIND3 MIG2B URP2
7012	ITGB1-RACK1 complex	Human	None	293T cells	P05556;P63244	3688;10399	MI:0018-two hybrid;MI:0019-coimmunoprecipitation	GO:0005080;GO:2001044	protein kinase C binding;regulation of integrin-mediated signaling pathway	None	None	9442085	The integrin beta subunit cytoplasmic domains are important for activation-dependent cell adhesion and adhesion-dependent signaling events. An interaction between integrin beta subunit cytoplasmic domain and Rack1, a Trp-Asp (WD) repeat protein that bind activated protein kinase C, has been shown. The Rack1-binding site on integrin beta 2 subunit resides within a conserved, membrane-proximal region. Rack1 co-immunoprecipitates with at least two different beta integrins, beta 1 integrins in 293T cells and beta 2 integrins in JY lymphoblastoid cells. The findings suggest that Rack1 may link protein kinase C directly to integrins and participate in the regulation of integrin functions.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-1;Receptor of activated protein C kinase 1	ITGB1;RACK1	FNRB, MDF2, MSK12;GNB2L1
7013	ITGB2-RACK1 complex	Human	None	JY lymphoblastoid cells	P05107;P63244	3689;10399	MI:0018-two hybrid;MI:0019-coimmunoprecipitation	GO:0005080;GO:2001044	protein kinase C binding;regulation of integrin-mediated signaling pathway	None	None	9442085	The integrin beta subunit cytoplasmic domains are important for activation-dependent cell adhesion and adhesion-dependent signaling events. An interaction between integrin beta subunit cytoplasmic domain and Rack1, a Trp-Asp (WD) repeat protein that bind activated protein kinase C, has been shown. The Rack1-binding site on integrin beta 2 subunit resides within a conserved, membrane-proximal region. Rack1 co-immunoprecipitates with at least two different beta integrins, beta 1 integrins in 293T cells and beta 2 integrins in JY lymphoblastoid cells. The findings suggest that Rack1 may link protein kinase C directly to integrins and participate in the regulation of integrin functions.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-2;Receptor of activated protein C kinase 1	ITGB2;RACK1	CD18 MFI7;GNB2L1
7014	GNAI1-GNGT1-GNB1 complex	Human	G-protein alphai1-gamma1-beta1	None	P62873;P63096;P63211	2782;2770;2792	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;Guanine nucleotide-binding protein G(i) subunit alpha-1;Guanine nucleotide-binding protein G(T) subunit gamma-T1	GNB1;GNAI1;GNGT1	None;None;None
7015	GNAI1-GNB2-GNGT1 complex	Human	G-protein alphai1-beta2-gamma1	None	P62879;P63096;P63211	2783;2770;2792	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2;Guanine nucleotide-binding protein G(i) subunit alpha-1;Guanine nucleotide-binding protein G(T) subunit gamma-T1	GNB2;GNAI1;GNGT1	None;None;None
7016	GNAI1-GNB3-GNGT1 complex	Human	G-protein alphai1-beta3-gamma1	None	P16520;P63096;P63211	2784;2770;2792	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3;Guanine nucleotide-binding protein G(i) subunit alpha-1;Guanine nucleotide-binding protein G(T) subunit gamma-T1	GNB3;GNAI1;GNGT1	None;None;None
7017	GNAI1-GNB4-GNGT1 complex	Human	G-protein alphai1-beta4-gamma1 complex	None	P63096;P63211;Q9HAV0	2770;2792;59345	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(i) subunit alpha-1;Guanine nucleotide-binding protein G(T) subunit gamma-T1;Guanine nucleotide-binding protein subunit beta-4	GNAI1;GNGT1;GNB4	None;None;None
7018	GNAI1-GNB5-GNGT1 complex	Human	G-protein alphai1-beta5-gamma1 complex	None	O14775;P63096;P63211	10681;2770;2792	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein subunit beta-5;Guanine nucleotide-binding protein G(i) subunit alpha-1;Guanine nucleotide-binding protein G(T) subunit gamma-T1	GNB5;GNAI1;GNGT1	None;None;None
7019	GNAI1-GNB1-GNG2 complex	Human	G-protein alphai1-beta1-gamma2 complex	None	P59768;P62873;P63096	54331;2782;2770	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;Guanine nucleotide-binding protein G(i) subunit alpha-1	GNG2;GNB1;GNAI1	None;None;None
7020	GNAI1-GNB2-GNG2 complex	Human	G-protein alphai1-beta2-gamma2 complex	None	P59768;P62879;P63096	54331;2783;2770	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2;Guanine nucleotide-binding protein G(i) subunit alpha-1	GNG2;GNB2;GNAI1	None;None;None
7021	GNAI1-GNB3-GNG2 complex	Human	G-protein alphai1-beta3-gamma2 complex	None	P16520;P59768;P63096	2784;54331;2770	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2;Guanine nucleotide-binding protein G(i) subunit alpha-1	GNB3;GNG2;GNAI1	None;None;None
7022	GNAI1-GNB4-GNG2 complex	Human	G-protein alphai1-beta4-gamma2 complex	None	P59768;P63096;Q9HAV0	54331;2770;59345	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2;Guanine nucleotide-binding protein G(i) subunit alpha-1;Guanine nucleotide-binding protein subunit beta-4	GNG2;GNAI1;GNB4	None;None;None
7023	GNAI1-GNB5-GNG2 complex	Human	G-protein alphai1-beta5-gamma2	None	O14775;P59768;P63096	10681;54331;2770	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein subunit beta-5;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2;Guanine nucleotide-binding protein G(i) subunit alpha-1	GNB5;GNG2;GNAI1	None;None;None
7024	GNAI1-GNB1-GNG3 complex	Human	G-protein alphaai1-beta1-gamma3 complex	None	P62873;P63096;P63215	2782;2770;2785	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;Guanine nucleotide-binding protein G(i) subunit alpha-1;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	GNB1;GNAI1;GNG3	None;None;GNGT3
7025	GNAI1-GNB2-GNG3 complex	Human	G-protein alphai1-beta2-gamma3 complex	None	P62879;P63096;P63215	2783;2770;2785	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2;Guanine nucleotide-binding protein G(i) subunit alpha-1;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	GNB2;GNAI1;GNG3	None;None;GNGT3
7026	GNAI1-GNB3-GNG3 complex	Human	G-protein alphai1-beta3-gamma3 complex	None	P16520;P63096;P63215	2784;2770;2785	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3;Guanine nucleotide-binding protein G(i) subunit alpha-1;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	GNB3;GNAI1;GNG3	None;None;GNGT3
7027	GNAI1-GNB4-GNG3 complex	Human	G-protein alphai1-beta4-gamma3 complex	None	P63096;P63215;Q9HAV0	2770;2785;59345	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(i) subunit alpha-1;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3;Guanine nucleotide-binding protein subunit beta-4	GNAI1;GNG3;GNB4	None;GNGT3;None
7028	GNAI1-GNB5-GNG3 complex	Human	G-protein alphai1-beta5-gamma3 complex	None	O14775;P63096;P63215	10681;2770;2785	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein subunit beta-5;Guanine nucleotide-binding protein G(i) subunit alpha-1;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	GNB5;GNAI1;GNG3	None;None;GNGT3
7029	IGF1-IGF1R-ITGA6-ITGB4 complex	Human	(Integrin alpha-6/beta-4)-IGF1-IGF1R complex; Apha6beta4-IGF1-IGF1R ternary complex	CHO cells expressing human genes	P05019;P08069;P16144;P23229	3479;3480;3691;3655	MI:0019-coimmunoprecipitation	GO:0048009;GO:0007160	insulin-like growth factor receptor signaling pathway;cell-matrix adhesion	30.05.01.12.04;34.07.02	IGF-receptor signalling pathway;cell-matrix adhesion	22351760	Alpha6beta4 is required when cell-matrix adhesion is reduced or in three-dimensional culture. The cross-talk between integrin alpha6beta4 and insulin-like growth factor-1 receptor (IGF1R) through direct alpha6beta4 binding to IGF1 and subsequent alpha6beta4-IGF1-IGF1R ternary complex formation in anchorage-independent conditions is reported.	Like alphavbeta3, integrin alpha6beta4 is overexpressed in many cancers and is implicated in cancer progression.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Insulin-like growth factor I;Insulin-like growth factor 1 receptor;Integrin beta-4;Integrin alpha-6	IGF1;IGF1R;ITGB4;ITGA6	IBP1;None;None;None
7030	DCP1A-NR3C1-PNRC2-UPF1-complex	Human	None	HEK293T cells	P04150;Q92900;Q9NPI6;Q9NPJ4	2908;5976;55802;55629	MI:0019-coimmunoprecipitation	GO:0000956;GO:0090025	nuclear-transcribed mRNA catabolic process;regulation of monocyte chemotaxis	None	None	25775514	Dexamethasone treatment triggers efficient formation of the DCP1A-NR3C1-PNRC2-UPF1-complex. The authors demonstrate that 'Glucocorticoid receptor-mediated mRNA decay' (GMD) targets a subset of cellular mRNAs. Results suggest that GMD plays an important role in the chemotaxis of monocytes via regulation of CCL2 mRNA stability.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Glucocorticoid receptor;Regulator of nonsense transcripts 1;mRNA-decapping enzyme 1A;Proline-rich nuclear receptor coactivator 2	NR3C1;UPF1;DCP1A;PNRC2	GRL;KIAA0221 RENT1;SMIF;None
7031	GNAI1-GNB1-GNG4 complex	Human	G-protein alphai1-beta1-gamma4	None	P50150;P62873;P63096	2786;2782;2770	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;Guanine nucleotide-binding protein G(i) subunit alpha-1	GNG4;GNB1;GNAI1	GNGT4;None;None
7032	GNAI1-GNB2-GNG4 complex	Human	G-protein alphai1-beta2-gamma4 complex	None	P50150;P62879;P63096	2786;2783;2770	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2;Guanine nucleotide-binding protein G(i) subunit alpha-1	GNG4;GNB2;GNAI1	GNGT4;None;None
7033	GNAI1-GNB3-GNG4 complex	Human	G-protein alphai1-beta3-gamma4 complex	None	P16520;P50150;P63096	2784;2786;2770	MI:0019-coimmunoprecipitation	None	None	None	None	0	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4;Guanine nucleotide-binding protein G(i) subunit alpha-1	GNB3;GNG4;GNAI1	None;GNGT4;None
7034	GNAI1-GNB4-GNG4 complex	Human	G-protein alphai1-beta4-gamma4 complex	None	P50150;P63096;Q9HAV0	2786;2770;59345	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4;Guanine nucleotide-binding protein G(i) subunit alpha-1;Guanine nucleotide-binding protein subunit beta-4	GNG4;GNAI1;GNB4	GNGT4;None;None
7035	GNAI1- GNB5-GNG4 complex	Human	G-protein alphai1-beta5-gamma4 complex	None	O14775;P50150;P63096	10681;2786;2770	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein subunit beta-5;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4;Guanine nucleotide-binding protein G(i) subunit alpha-1	GNB5;GNG4;GNAI1	None;GNGT4;None
7036	GNAI1-GNB1-GNG5 complex	Human	G-protein alphai1-beta1-gamma5 complex	None	P62873;P63096;P63218	2782;2770;2787	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;Guanine nucleotide-binding protein G(i) subunit alpha-1;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	GNB1;GNAI1;GNG5	None;None;GNGT5
7037	GNAI1-GNB2-GNG5 complex	Human	G-prtotein alphai1-beta2-gamma5 complex	None	P62879;P63096;P63218	2783;2770;2787	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2;Guanine nucleotide-binding protein G(i) subunit alpha-1;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	GNB2;GNAI1;GNG5	None;None;GNGT5
7038	BVR-PKCD-ERK2 complex	Human	BLVRA-MAPK1-PRKCD complex	HEK293A cells	P28482;P53004;Q05655	5594;644;5580	MI:0019-coimmunoprecipitation;MI:0051-fluorescence technology	GO:0070372;GO:0008283	regulation of ERK1 and ERK2 cascade;cell population proliferation	None	None	22065579	The BVR-PKCdelta-ERK2 ternary complex is essential for ERK2 signal transduction and activation of genes are linked to cell proliferation and cancer. MEK1/2 and the protein phosphatase PP2A were also present in the complex. hBVR and ERK2 were phosphorylated by PKCdelta. hBVR was required for the activation of PKCdelta and its interaction with ERK2. The C-terminal phenylalanine residues of PKCdelta (Phe(660), Phe(663), and Phe(665)) were necessary for binding to ERK2 but not for hBVR binding. Formation of the hBVR-PKCdelta-ERK2 complex required the hBVR docking site for ERK, FXFP (DEF, C-box) and D(delta)-box (ILXXLXL) motifs.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mitogen-activated protein kinase 1;Biliverdin reductase A;Protein kinase C delta type	MAPK1;BLVRA;PRKCD	ERK2 PRKM1 PRKM2;BLVR BVR;PKCD
7040	PDZK1-PLCB3-SSTR5 complex	Human	None	HEK293 cells	P35346;Q01970;Q5T2W1	6755;5331;5174	MI:0019-coimmunoprecipitation;MI:0047-far western blotting;MI:0096-pull down	GO:0038170;GO:0031882;GO:0007186	somatostatin signaling pathway;type 5 somatostatin receptor binding;G protein-coupled receptor signaling pathway	30.05.02.24	G-protein coupled receptor signalling pathway	22528496	Phospholipase C-beta (PLC-beta) is a key molecule in G protein-coupled receptor (GPCR)-mediated signaling. The formation of complexes between somatostatin receptors (SSTRs 1-5), PDZK1 (PDZ domain-containing 1), and PLC-beta3 is essential for the specific activation of PLC-beta3 and the subsequent physiologic responses by somatostatin (SST). SSTR5 not only interacted with PDZK1 but also interacted with endogenous PLC-beta3, but not with PLC-beta1. It was also confirmed that other SSTR isotypes (SSTR1-4) interact with PDZK1 and form complexes with PLC-beta3.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Somatostatin receptor type 5;1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3;Na(+)/H(+) exchange regulatory cofactor NHE-RF3	SSTR5;PLCB3;PDZK1	None;None;CAP70 NHERF3 PDZD1
7041	PDZK1-PLCB3-SSTR1 complex	Human	None	HEK293 cells	P30872;Q01970;Q5T2W1	6751;5331;5174	MI:0019-coimmunoprecipitation;MI:0047-far western blotting;MI:0096-pull down	GO:0007186;GO:0038170;GO:0031878	G protein-coupled receptor signaling pathway;somatostatin signaling pathway;type 1 somatostatin receptor binding	30.05.02.24	G-protein coupled receptor signalling pathway	22528496	Phospholipase C-beta (PLC-beta) is a key molecule in G protein-coupled receptor (GPCR)-mediated signaling. The formation of complexes between somatostatin receptors (SSTRs 1-5), PDZK1 (PDZ domain-containing 1), and PLC-beta3 is essential for the specific activation of PLC-beta3 and the subsequent physiologic responses by somatostatin (SST).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Somatostatin receptor type 1;1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3;Na(+)/H(+) exchange regulatory cofactor NHE-RF3	SSTR1;PLCB3;PDZK1	None;None;CAP70 NHERF3 PDZD1
7042	PDZK1-PLCB3-SSTR2 complex	Human	None	HEK293 cells	P30874;Q01970;Q5T2W1	6752;5331;5174	MI:0019-coimmunoprecipitation;MI:0047-far western blotting;MI:0096-pull down	GO:0007186;GO:0038170;GO:0031879	G protein-coupled receptor signaling pathway;somatostatin signaling pathway;type 2 somatostatin receptor binding	30.05.02.24	G-protein coupled receptor signalling pathway	22528496	Phospholipase C-beta (PLC-beta) is a key molecule in G protein-coupled receptor (GPCR)-mediated signaling. The formation of complexes between somatostatin receptors (SSTRs 1-5), PDZK1 (PDZ domain-containing 1), and PLC-beta3 is essential for the specific activation of PLC-beta3 and the subsequent physiologic responses by somatostatin (SST).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Somatostatin receptor type 2;1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3;Na(+)/H(+) exchange regulatory cofactor NHE-RF3	SSTR2;PLCB3;PDZK1	None;None;CAP70 NHERF3 PDZD1
7043	PDZK1-PLCB3-SSTR3 complex	Human	None	HEK293 cells	P32745;Q01970;Q5T2W1	6753;5331;5174	MI:0019-coimmunoprecipitation;MI:0047-far western blotting;MI:0096-pull down	GO:0007186;GO:0038170;GO:0031880	G protein-coupled receptor signaling pathway;somatostatin signaling pathway;type 3 somatostatin receptor binding	30.05.02.24	G-protein coupled receptor signalling pathway	22528496	Phospholipase C-beta (PLC-beta) is a key molecule in G protein-coupled receptor (GPCR)-mediated signaling. The formation of complexes between somatostatin receptors (SSTRs 1-5), PDZK1 (PDZ domain-containing 1), and PLC-beta3 is essential for the specific activation of PLC-beta3 and the subsequent physiologic responses by somatostatin (SST).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Somatostatin receptor type 3;1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3;Na(+)/H(+) exchange regulatory cofactor NHE-RF3	SSTR3;PLCB3;PDZK1	None;None;CAP70 NHERF3 PDZD1
7044	PDZK1-PLCB3-SSTR4 complex	Human	None	HEK293 cells	P31391;Q01970;Q5T2W1	6754;5331;5174	MI:0019-coimmunoprecipitation;MI:0047-far western blotting;MI:0096-pull down	GO:0007186;GO:0038170;GO:0031881	G protein-coupled receptor signaling pathway;somatostatin signaling pathway;type 4 somatostatin receptor binding	30.05.02.24	G-protein coupled receptor signalling pathway	22528496	Phospholipase C-beta (PLC-beta) is a key molecule in G protein-coupled receptor (GPCR)-mediated signaling. The formation of complexes between somatostatin receptors (SSTRs 1-5), PDZK1 (PDZ domain-containing 1), and PLC-beta3 is essential for the specific activation of PLC-beta3 and the subsequent physiologic responses by somatostatin (SST).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Somatostatin receptor type 4;1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3;Na(+)/H(+) exchange regulatory cofactor NHE-RF3	SSTR4;PLCB3;PDZK1	None;None;CAP70 NHERF3 PDZD1
7045	IFNAR1-IFNAR2-IFNW1 complex	Human	IFN alpha receptor-IFN omega1 complex; Type I IFN receptor-IFN omega1 complex; Type I interferon receptor-Interferon omega1 complex; IFNAR1-IFNAR2-IFNW1 complex; IFNomega1 ternary complex	HEK293 cells	P05000;P17181;P48551	3467;3454;3455	MI:0114-x-ray crystallography	GO:0019221;GO:0045087;GO:0042509;GO:0060337;GO:0051607	cytokine-mediated signaling pathway;innate immune response;regulation of tyrosine phosphorylation of STAT protein;type I interferon signaling pathway;defense response to virus	36.25.16.01	innate immune response (invertebrates and vertebrates)	21854986	Type I Interferons (IFNs) are important cytokines for innate immunity against viruses and cancer.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Interferon omega-1;Interferon alpha/beta receptor 1;Interferon alpha/beta receptor 2	IFNW1;IFNAR1;IFNAR2	None;IFNAR;IFNABR IFNARB
7046	IFNAR2-IFNA2 complex	Human	Type I IFN complex	HEK293 cells	P01563;P48551	3440;3455	MI:0114-x-ray crystallography	GO:0005125;GO:0005126;GO:0005132	cytokine activity;cytokine receptor binding;type I interferon receptor binding	40.02.03.01	cytokines (interleukines, colony stimulating factors, etc.)	21854986	Type I Interferons (IFNs) are important cytokines for innate immunity against viruses and cancer.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Interferon alpha-2;Interferon alpha/beta receptor 2	IFNA2;IFNAR2	IFNA2A IFNA2B IFNA2C;IFNABR IFNARB
7047	IFNAR1-IFNAR2-IFNA2 complex	Human	IFN alpha receptor-IFN alpha2 complex; Type I interferon receptor-Interferon alpha2 complex; IFNAR1-IFNAR2-IFNA2 complex; IFNalpha2 ternary complex	HEK293 cells	P01563;P17181;P48551	3440;3454;3455	MI:0114-x-ray crystallography	GO:0045087;GO:0019221;GO:0060337;GO:0042509;GO:0051607	innate immune response;cytokine-mediated signaling pathway;type I interferon signaling pathway;regulation of tyrosine phosphorylation of STAT protein;defense response to virus	36.25.16.01	innate immune response (invertebrates and vertebrates)	21854986	Type I Interferons (IFNs) are important cytokines for innate immunity against viruses and cancer.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Interferon alpha-2;Interferon alpha/beta receptor 1;Interferon alpha/beta receptor 2	IFNA2;IFNAR1;IFNAR2	IFNA2A IFNA2B IFNA2C;IFNAR;IFNABR IFNARB
7048	TLR1-TLR2 complex	Human	TLR1-TLR2 heterodimer; Toll-like receptor 1-Toll-like receptor 2 complex	HEK293 cells	O60603;Q15399	7097;7096	MI:0114-x-ray crystallography	GO:0045087;GO:0002224;GO:0002221;GO:0042742;GO:0051092;GO:0038123;GO:0071723;GO:0070339	innate immune response;toll-like receptor signaling pathway;pattern recognition receptor signaling pathway;defense response to bacterium;positive regulation of NF-kappaB transcription factor activity;toll-like receptor TLR1:TLR2 signaling pathway;lipopeptide binding;response to bacterial lipopeptide	36.25.16.01	innate immune response (invertebrates and vertebrates)	17889651	TLR2 in association with TLR1 or TLR6 plays an important role in the innate immune response by recognizing microbial lipoproteins and lipopeptides. Binding of the tri-acylated lipopeptide, Pam(3)CSK(4), induced the formation of an "m" shaped heterodimer of the TLR1 and TLR2 ectodomains whereas binding of the di-acylated lipopeptide, Pam(2)CSK(4), did not. The three lipid chains of Pam(3)CSK(4) mediate the heterodimerization of the receptor; the two ester-bound lipid chains are inserted into a pocket in TLR2, while the amide-bound lipid chain is inserted into a hydrophobic channel in TLR1. An extensive hydrogen-bonding network, as well as hydrophobic interactions, between TLR1 and TLR2 further stabilize the heterodimer.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Toll-like receptor 2;Toll-like receptor 1	TLR2;TLR1	TIL4;KIAA0012
7050	PIAS1-SUMO1-UBC9 complex	Human	PIAS1-SUMO1-UBE2I ternary complex	HEK293T cells	O75925;P63165;P63279	8554;7341;7329	MI:0012-bioluminescence resonance energy transfer;MI:0065-isothermal titration calorimetry;MI:0077-nuclear magnetic resonance	GO:0032183;GO:0061665;GO:0003714	SUMO binding;SUMO ligase activity;transcription corepressor activity	None	None	24174529	UBC9 and PIAS1 are engaged both in a canonical E2\u00b7E3 interaction as well as assembled into a previously unidentified non-covalent ternary complex with SUMO as evidenced by bioluminescence resonance energy transfer, nuclear magnetic resonance spectroscopy, and isothermal titration calorimetry studies. In this ternary complex, SUMO functions as a bridge by forming non-overlapping interfaces with UBC9 and PIAS1. Data suggest that phosphorylation of serine residues adjacent to the PIAS1 SUMO-interacting motif favors formation of the non covalent PIAS1\u00b7SUMO\u00b7UBC9 ternary complex. The non-covalent ternary complex is required for the known transcriptional repression activities mediated by UBC9 and SUMO1.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 SUMO-protein ligase PIAS1;Small ubiquitin-related modifier 1;SUMO-conjugating enzyme UBC9	PIAS1;SUMO1;UBE2I	DDXBP1;SMT3C SMT3H3 UBL1;UBC9 UBCE9
7051	OTUB1-UBC13-MMS2 complex	Human	OTUB1-UBE2N-UBE2V2 complex	U2OS cells; 293T cells	P61088;Q15819;Q96FW1	7334;7336;55611	MI:0019-coimmunoprecipitation;MI:0047-far western blotting;MI:0107-surface plasmon resonance;MI:0114-x-ray crystallography	GO:0031625;GO:0016579;GO:0016567;GO:0006282;GO:0006302;GO:0000209;GO:0004842	ubiquitin protein ligase binding;protein deubiquitination;protein ubiquitination;regulation of DNA repair;double-strand break repair;protein polyubiquitination;ubiquitin-protein transferase activity	14.07.05	modification by ubiquitination, deubiquitination	22679021	A deubiquitinating enzyme OTUB1 inhibits Lys-63-linked ubiquitination by binding to a ubiquitin-conjugating enzyme UBC13. The mechanism of human OTUB1-UBC13 interaction was revealed by human OTUB1-UBC13-MMS2 complex structure and structure-based mutagenesis. The atomic-level interactions presented by the OTUB1-UBC13-MMS2 complex structure are critical for Lys-63-linked ubiquitination inhibition.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Ubiquitin-conjugating enzyme E2 N;Ubiquitin-conjugating enzyme E2 variant 2;Ubiquitin thioesterase OTUB1	UBE2N;UBE2V2;OTUB1	BLU;MMS2, UEV2;OTB1 OTU1
7057	Propionyl-CoA carboxylase	Human	Propionyl-coenzyme A carboxylase, PCC holoenzyme	None	P05165;P05166	5095;5096	MI:0040-electron microscopy;MI:0071-molecular sieving;MI:0114-x-ray crystallography	GO:0005739;GO:0009374;GO:0004658	mitochondrion;biotin binding;propionyl-CoA carboxylase activity	70.16;16.21.15	mitochondrion;biotin binding	20725044	The holoenzyme of Propionyl-coenzyme A carboxylase is an alpha(6)beta(6) dodecamer, with a molecular mass of 750 kDa. Biotin is an obligate co-factor.	Deficiencies in the biotin-dependent enzyme propionyl-coenzyme A carboxylase are linked to propionic acidemia. (PMID:29033250)	None	Homo sapiens (Human);Homo sapiens (Human)	Propionyl-CoA carboxylase alpha chain, mitochondrial;Propionyl-CoA carboxylase beta chain, mitochondrial	PCCA;PCCB	None;None
7058	HEG1-KRIT1-RAP1B complex	Human	CCM1-HEG1-RAP1 complex	in vitro	O00522;P61224;Q9ULI3	889;5908;57493	MI:0047-far western blotting;MI:0096-pull down;MI:0114-x-ray crystallography;MI:0276-blue native page	GO:0003924;GO:0005886	GTPase activity;plasma membrane	70.02	eukaryotic plasma membrane / membrane attached	23814056	KRIT1 FERM domain can bind Rap1 GTPase and HEG1 cytoplasmic tail. The biological function of KRIT1 requires that its FERM domain physically interacts with both the small GTPase Rap1 and the cytoplasmic tail of the Heart of glass (HEG1) membrane anchor.	CCMs (Cerebral Cavernous Malformations ) occur in both sporadic and autosomal dominant inherited forms, and the latter are due to heterozygous mutations at three loci, CCM1 (KRIT1), CCM2 (OSM), and CCM3 (PDCD10).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Krev interaction trapped protein 1;Ras-related protein Rap-1b;Protein HEG homolog 1	KRIT1;RAP1B;HEG1	CCM1;None;KIAA1237
7059	GNAI1-GNB3-GNG5 complex	Human	G-protein alphai1-beta3-gamma5 complex	None	P16520;P63096;P63218	2784;2770;2787	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3;Guanine nucleotide-binding protein G(i) subunit alpha-1;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	GNB3;GNAI1;GNG5	None;None;GNGT5
7060	GNAI1-GNB4-GNG5 complex	Human	G-protein alphai1-beta4-gamma5 complex	None	P63096;P63218;Q9HAV0	2770;2787;59345	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(i) subunit alpha-1;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5;Guanine nucleotide-binding protein subunit beta-4	GNAI1;GNG5;GNB4	None;GNGT5;None
7061	GNAI1-GNB5-GNG5 complex	Human	G-prtotein alphai1-beta5-gamma5 complex	None	O14775;P63096;P63218	10681;2770;2787	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein subunit beta-5;Guanine nucleotide-binding protein G(i) subunit alpha-1;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	GNB5;GNAI1;GNG5	None;None;GNGT5
7062	NFAT5-WWTR1 complex	Human	NFAT5-TAZ complex	293T cells	O94916;Q9GZV5	10725;25937	MI:0019-coimmunoprecipitation	GO:0006970	response to osmotic stress	34.11.03.13	osmosensing  and response	23045390	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Nuclear factor of activated T-cells 5;WW domain-containing transcription regulator protein 1	NFAT5;WWTR1	KIAA0827,TONEBP;TAZ
7063	C9orf72-SMCR8-WDR41 complex	Human	None	HEK293T cells	Q8TEV9;Q96LT7;Q9HAD4	140775;203228;55255	MI:0019-coimmunoprecipitation	GO:0006914;GO:0000139	autophagy;Golgi membrane	None	None	27193190	The ALS (amyotrophic lateral sclerosis) and FTLD (frontotemporal lobar degeneration) associated protein C9orf72 interacts with SMCR8 and WDR41 to regulate the autophagy-lysosome pathway. WDR41 is tightly associated with the Golgi complex. WDR41 interacts with the C9orf72/SMCR8 dimer to form ternary complex, which then interacts with the FIP200/Ulk1/ATG13/ATG101 complex.	Hexanucleotide repeat expansion in the C9orf72 gene has been shown to be the main cause of ALS (amyotrophic lateral sclerosis) / FTLD (frontotemporal lobar degeneration).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide exchange protein SMCR8;Guanine nucleotide exchange factor C9orf72;WD repeat-containing protein 41	SMCR8;C9orf72;WDR41	None;DENND9 DENNL72;None
7064	C9orf72-SMCR8 complex	Human	None	HEK293T cells	Q8TEV9;Q96LT7	140775;203228	MI:0019-coimmunoprecipitation	GO:0006914;GO:0000139	autophagy;Golgi membrane	None	None	27193190	The ALS (amyotrophic lateral sclerosis) and FTLD (frontotemporal lobar degeneration) associated protein C9orf72 interacts with SMCR8 and WDR41 to regulate the autophagy-lysosome pathway. WDR41 is tightly associated with the Golgi complex. WDR41 interacts with the C9orf72/SMCR8 dimer to form ternary complex, which then interacts with the FIP200/Ulk1/ATG13/ATG101 complex.	Hexanucleotide repeat expansion in the C9orf72 gene has been shown to be the main cause of ALS (amyotrophic lateral sclerosis) / FTLD (frontotemporal lobar degeneration).	None	Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide exchange protein SMCR8;Guanine nucleotide exchange factor C9orf72	SMCR8;C9orf72	None;DENND9 DENNL72
7065	WDR41-(C9orf72-SMCR8)-(FIP200-ULK1-ATG13-ATG101) complex	Human	None	HEK293T cells	O75143;O75385;Q8TDY2;Q8TEV9;Q96LT7;Q9BSB4;Q9HAD4	9776;8408;9821;140775;203228;60673;55255	MI:0019-coimmunoprecipitation	GO:0006914;GO:0000139	autophagy;Golgi membrane	None	None	27193190	The ALS (amyotrophic lateral sclerosis) and FTLD (frontotemporal lobar degeneration) associated protein C9orf72 interacts with SMCR8 and WDR41 to regulate the autophagy-lysosome pathway. WDR41 is tightly associated with the Golgi complex. WDR41 interacts with the C9orf72/SMCR8 dimer to form ternary complex, which then interacts with the FIP200/Ulk1/ATG13/ATG101 complex.	Hexanucleotide repeat expansion in the C9orf72 gene has been shown to be the main cause of ALS (amyotrophic lateral sclerosis) / FTLD (frontotemporal lobar degeneration).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Autophagy-related protein 13;Serine/threonine-protein kinase ULK1;RB1-inducible coiled-coil protein 1;Guanine nucleotide exchange protein SMCR8;Guanine nucleotide exchange factor C9orf72;Autophagy-related protein 101;WD repeat-containing protein 41	ATG13;ULK1;RB1CC1;SMCR8;C9orf72;ATG101;WDR41	KIAA0652;KIAA0722;KIAA0203 RBICC;None;DENND9 DENNL72;C12orf44;None
7066	GNAI1-GNB1-GNG7 complex	Human	G-protein alphai1-beta1-gamma7 complex	None	O60262;P62873;P63096	2788;2782;2770	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;Guanine nucleotide-binding protein G(i) subunit alpha-1	GNG7;GNB1;GNAI1	GNGT7;None;None
7067	GNAI1-GNB2-GNG7 complex	Human	G-protein alphai1-beta2-gamma7 complex	None	O60262;P62879;P63096	2788;2783;2770	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2;Guanine nucleotide-binding protein G(i) subunit alpha-1	GNG7;GNB2;GNAI1	GNGT7;None;None
7068	GNAI1-GNB3-GNG7 complex	Human	G-protein alphai1-beta3-gamma7 complex	None	O60262;P16520;P63096	2788;2784;2770	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3;Guanine nucleotide-binding protein G(i) subunit alpha-1	GNG7;GNB3;GNAI1	GNGT7;None;None
7069	GNAI1-GNB4-GNG7 complex	Human	G-protein alphai1-beta4-gamma7 complex	None	O60262;P63096;Q9HAV0	2788;2770;59345	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7;Guanine nucleotide-binding protein G(i) subunit alpha-1;Guanine nucleotide-binding protein subunit beta-4	GNG7;GNAI1;GNB4	GNGT7;None;None
7070	GNAI1-GNB5-GNG7 complex	Human	G-protein alphai1-beta5-gamma7 complex	None	O14775;O60262;P63096	10681;2788;2770	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein subunit beta-5;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7;Guanine nucleotide-binding protein G(i) subunit alpha-1	GNB5;GNG7;GNAI1	None;GNGT7;None
7071	GNAI1-GNB1-GNG8 complex	Human	G-protein alphai1-beta1-gamma8 complex	None	P62873;P63096;Q9UK08	2782;2770;94235	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;Guanine nucleotide-binding protein G(i) subunit alpha-1;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	GNB1;GNAI1;GNG8	None;None;GNG9 GNGT9
7072	GNAI1-GNB2-GNG8 complex	Human	G-protein alphai1-beta2-gamma8 complex	None	P62879;P63096;Q9UK08	2783;2770;94235	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2;Guanine nucleotide-binding protein G(i) subunit alpha-1;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	GNB2;GNAI1;GNG8	None;None;GNG9 GNGT9
7073	GNAI1-GNB3-GNG8 complex	Human	G-protein alphai1-beta3-gamma8 complex	None	P16520;P63096;Q9UK08	2784;2770;94235	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3;Guanine nucleotide-binding protein G(i) subunit alpha-1;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	GNB3;GNAI1;GNG8	None;None;GNG9 GNGT9
7074	GNAI1-GNB4-GNG8 complex	Human	G-protein alphai1-beta4-gamma8 complex	None	P63096;Q9HAV0;Q9UK08	2770;59345;94235	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(i) subunit alpha-1;Guanine nucleotide-binding protein subunit beta-4;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	GNAI1;GNB4;GNG8	None;None;GNG9 GNGT9
7075	GNAI1-GNB5-GNG8 complex	Human	G-protein alphai1-beta5-gamma8 complex	None	O14775;P63096;Q9UK08	10681;2770;94235	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein subunit beta-5;Guanine nucleotide-binding protein G(i) subunit alpha-1;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	GNB5;GNAI1;GNG8	None;None;GNG9 GNGT9
7076	GNAI1-GNB1-GNG10 complex	Human	G-protein alphai1-beta1-gamma10 complex	None	P50151;P62873;P63096	2790;2782;2770	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;Guanine nucleotide-binding protein G(i) subunit alpha-1	GNG10;GNB1;GNAI1	GNGT10;None;None
7077	GNAI1-GNB2-GNG10 complex	Human	G-protein alphai1-beta2-gamma10 complex	None	P50151;P62879;P63096	2790;2783;2770	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2;Guanine nucleotide-binding protein G(i) subunit alpha-1	GNG10;GNB2;GNAI1	GNGT10;None;None
7078	GNAI1-GNB3-GNG10 complex	Human	G-protein alphai1-beta3-gamma10 complex	None	P16520;P50151;P63096	2784;2790;2770	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10;Guanine nucleotide-binding protein G(i) subunit alpha-1	GNB3;GNG10;GNAI1	None;GNGT10;None
7079	GNAI1-GNB4-GNG10 complex	Human	G-protein alphai1-beta4-gamma10 complex	None	P50151;P63096;Q9HAV0	2790;2770;59345	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10;Guanine nucleotide-binding protein G(i) subunit alpha-1;Guanine nucleotide-binding protein subunit beta-4	GNG10;GNAI1;GNB4	GNGT10;None;None
7080	GNAI1-GNB5-GNG10 complex	Human	G-protein alphai1-beta5-gamma10 complex	None	O14775;P50151;P63096	10681;2790;2770	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein subunit beta-5;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10;Guanine nucleotide-binding protein G(i) subunit alpha-1	GNB5;GNG10;GNAI1	None;GNGT10;None
7081	GNAI1-GNB1-GNG11 complex	Human	G-protein alphai1-beta1-gamma11 complex	None	P61952;P62873;P63096	2791;2782;2770	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;Guanine nucleotide-binding protein G(i) subunit alpha-1	GNG11;GNB1;GNAI1	GNGT11;None;None
7082	GNAI1-GNB2-GNG11 complex	Human	G-protein alphai1-beta2-gamma11 complex	None	P61952;P62879;P63096	2791;2783;2770	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2;Guanine nucleotide-binding protein G(i) subunit alpha-1	GNG11;GNB2;GNAI1	GNGT11;None;None
7083	GNAI1-GNB3-GNG11 complex	Human	G-protein alphai1-beta3-gamma11 complex	None	P16520;P61952;P63096	2784;2791;2770	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11;Guanine nucleotide-binding protein G(i) subunit alpha-1	GNB3;GNG11;GNAI1	None;GNGT11;None
7084	GNAI1-GNB4-GNG11 complex	Human	G-protein alphai1-beta4-gamma11 complex	None	P61952;P63096;Q9HAV0	2791;2770;59345	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11;Guanine nucleotide-binding protein G(i) subunit alpha-1;Guanine nucleotide-binding protein subunit beta-4	GNG11;GNAI1;GNB4	GNGT11;None;None
7085	GNAI1-GNB5-GNG11 complex	Human	G-protein alphai1-beta5-gamma11 complex	None	O14775;P61952;P63096	10681;2791;2770	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein subunit beta-5;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11;Guanine nucleotide-binding protein G(i) subunit alpha-1	GNB5;GNG11;GNAI1	None;GNGT11;None
7086	GNAI1-GNB1-GNG12 complex	Human	G-protein alphai1-beta1-gamma12 complex	None	P62873;P63096	2782;2770	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;Guanine nucleotide-binding protein G(i) subunit alpha-1	GNB1;GNAI1	None;None
7087	GNAI1-GNB2-GNG12 complex	Human	G-protein alphai1-beta2-gamma12 complex	None	P62879;P63096;Q9UBI6	2783;2770;55970	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2;Guanine nucleotide-binding protein G(i) subunit alpha-1;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	GNB2;GNAI1;GNG12	None;None;None
7088	GNAI1-GNB3-GNG12 complex	Human	G-protein alphai1-beta3-gamma12 complex	None	P16520;P63096;Q9UBI6	2784;2770;55970	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3;Guanine nucleotide-binding protein G(i) subunit alpha-1;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	GNB3;GNAI1;GNG12	None;None;None
7089	GNAI1-GNB4-GNG12 complex	Human	G-protein alphai1-beta4-gamma12 complex	None	P63096;Q9HAV0;Q9UBI6	2770;59345;55970	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(i) subunit alpha-1;Guanine nucleotide-binding protein subunit beta-4;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	GNAI1;GNB4;GNG12	None;None;None
7090	GNAI1-GNB5-GNG12 complex	Human	G-protein alphai1-beta5-gamma12 complex	None	O14775;P63096;Q9UBI6	10681;2770;55970	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein subunit beta-5;Guanine nucleotide-binding protein G(i) subunit alpha-1;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	GNB5;GNAI1;GNG12	None;None;None
7092	GNAI1-GNB1-GNG13 complex	Human	G-protein alphai1-beta1-gamma13 complex	None	P62873;P63096;Q9P2W3	2782;2770;51764	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;Guanine nucleotide-binding protein G(i) subunit alpha-1;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13	GNB1;GNAI1;GNG13	None;None;None
7093	GNAI1-GNB2-GNG13 complex	Human	G-protein alphai1-beta2-gamma13 complex	None	P62879;P63096;Q9P2W3	2783;2770;51764	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2;Guanine nucleotide-binding protein G(i) subunit alpha-1;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13	GNB2;GNAI1;GNG13	None;None;None
7094	GNAI1-GNB3-GNG13 complex	Human	G-protein alphai1-beta3-gamma13 complex	None	P16520;P63096;Q9P2W3	2784;2770;51764	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3;Guanine nucleotide-binding protein G(i) subunit alpha-1;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13	GNB3;GNAI1;GNG13	None;None;None
7095	GNAI1-GNB4-GNG13 complex	Human	G-protein alphai1-beta4-gamma13 complex	None	P63096;Q9HAV0;Q9P2W3	2770;59345;51764	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(i) subunit alpha-1;Guanine nucleotide-binding protein subunit beta-4;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13	GNAI1;GNB4;GNG13	None;None;None
7096	GNAI1-GNB5-GNG13 complex	Human	G-protein alphai1-beta5-gamma13 complex	None	O14775;P63096;Q9P2W3	10681;2770;51764	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein subunit beta-5;Guanine nucleotide-binding protein G(i) subunit alpha-1;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13	GNB5;GNAI1;GNG13	None;None;None
7097	GNAS-L-GNB1-GNG1 complex	Human	G-protein alpha(s)-L-beta1-gamma1 complex	None	P62873;P63092;P63211	2782;2778;2792	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(T) subunit gamma-T1	GNB1;GNAS;GNGT1	None;GNAS1 GSP;None
7098	ASAH1-NR5A1 complex	Human	Acid ceramidase-SF1 complex	H295R cells	Q13285;Q13510	2516;427	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0003713;GO:0004879	transcription coactivator activity;nuclear receptor activity	None	None	22927646	The ability of the ASAH1 (acid ceramidase) to repress SF-1 (Steroidogenic Factor 1)-dependent gene transcription in H295R human adrenocortical cells requires a direct interaction with the receptor.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Steroidogenic factor 1;Acid ceramidase	NR5A1;ASAH1	AD4BP, FTZF1, SF1;ASAH
7099	ASAH1-NR5A1-SAPD complex	Human	Acid ceramidase-SF1-SAPD complex	H295R cells	P07602;Q13285;Q13510	5660;2516;427	MI:0019-coimmunoprecipitation	GO:0004879;GO:0003713	nuclear receptor activity;transcription coactivator activity	None	None	22927646	ASAH1 and its coactivator protein SAP-D are expressed in the nuclear envelope and nucleoplasmic fractions. Endogenous ASAH1 and SAP-D coimmunoprecipitate with SF-1.	None	The saponsin precursor is proteolytically processed to generate four main cleavage products including saposins A, B, C, and D. As no UniProtId is given for SAP-D, the ID of prosaposin is used.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Prosaposin;Steroidogenic factor 1;Acid ceramidase	PSAP;NR5A1;ASAH1	GLBA, SAP1;AD4BP, FTZF1, SF1;ASAH
7100	DNAAF2-HEATR2-SPAG1 complex	Human	DNAAF2-DNAAF5-SPAG1 complex	Primary airway epithelial cells; MCIDAS-regulated induced pluripotent stem cells	Q07617;Q86Y56;Q9NVR5	6674;54919;55172	MI:0019-coimmunoprecipitation;MI:0055-fluorescent resonance energy transfer	GO:0003341;GO:0060271	cilium movement;cilium assembly	None	None	29358401	None	Human mutations in HEATR2 did not affect this interaction, but triggered the formation of p62/Sequestosome-1-positive aggregates containing the early preassembly proteins, suggesting that degradation of an early preassembly complex is responsible for disease and pointing to key regions required for HEATR2 scaffold stability. It was speculated that HEATR2 is an early scaffold for the initiation of dynein complex assembly in motile cilia (PMID:29358401).OMIM:614874 Ciliary dyskinesia, primary, 18	FRET analysis of HEAT domain deletions and human mutations showed that HEATR2 interacted with itself and SPAG1 at multiple HEAT domains, while DNAAF2 interacted with SPAG1 (PMID:29358401).	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Sperm-associated antigen 1;Dynein axonemal assembly factor 5;Protein kintoun	SPAG1;DNAAF5;DNAAF2	None;HEATR2;C14orf104 KTU
7101	AURKB-VRK1 complex	Human	None	HeLa cells	Q96GD4;Q99986	9212;7443	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0006338;GO:0035174	chromatin remodeling;histone serine kinase activity	None	None	29340707	VRK1 and\u00a0AURKB interaction inhibits phosphorylation of\u00a0histone H3 in\u00a0vivo (PMID:29340707).	None	None	Homo sapiens (Human);Homo sapiens (Human)	Aurora kinase B;Serine/threonine-protein kinase VRK1	AURKB;VRK1	AIK2 AIM1 AIRK2 ARK2 STK1 STK12 STK5;None
7102	SOX2-VRK1 complex	Human	None	None	P48431;Q99986	6657;7443	MI:0019-coimmunoprecipitation	GO:0008283;GO:0001010	cell population proliferation;RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity	None	None	27334688	Sox2 and VRK1 proteins synergistically cooperate in the activation of CCND1 gene expression and thus can contribute together to cell cycle progression and proliferation (PMID: 27334688).	None	None	Homo sapiens (Human);Homo sapiens (Human)	Transcription factor SOX-2;Serine/threonine-protein kinase VRK1	SOX2;VRK1	None;None
7103	NBS1-VRK1 complex	Human	None	HEK293T cells	O60934;Q99986	4683;7443	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:2001020	regulation of response to DNA damage stimulus	None	None	26869104	The preassembled NBS1\u2013VRK1 complex that is activated by DNA damage and that contributes to the stability of NBS1 thus facilitating the sequential steps inn DNA damage response (PMID:26869104).	None	None	Homo sapiens (Human);Homo sapiens (Human)	Nibrin;Serine/threonine-protein kinase VRK1	NBN;VRK1	NBS NBS1 P95;None
7104	NBN\u2013RNF8-VRK1 complex	Human	None	None	O60934;O76064;Q99986	4683;9025;7443	MI:0019-coimmunoprecipitation	None	None	None	None	26869104	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Nibrin;E3 ubiquitin-protein ligase RNF8;Serine/threonine-protein kinase VRK1	NBN;RNF8;VRK1	NBS NBS1 P95;KIAA0646;None
7105	PRRX1-UCHL1 complex	Human	None	HELA cells	P09936;P54821	7345;5396	MI:0019-coimmunoprecipitation	None	None	None	None	29339092	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Ubiquitin carboxyl-terminal hydrolase isozyme L1;Paired mesoderm homeobox protein 1	UCHL1;PRRX1	None;PMX1
7106	PRRX2-UCHL1 complex	Human	None	HeLa cells	P09936;Q99811	7345;51450	MI:0019-coimmunoprecipitation	None	None	None	None	29339092	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Ubiquitin carboxyl-terminal hydrolase isozyme L1;Paired mesoderm homeobox protein 2	UCHL1;PRRX2	None;PMX2 PRX2
7107	IGF2R-PLAUR-PLG complex	Human	(M6P/IGFII-R)-(uPA-R)-PLG complex	human monocytes (PBMC); U937 cells	P00747;P11717;Q03405	5340;3482;5329	MI:0019-coimmunoprecipitation	GO:0005159;GO:0030377;GO:0036364;GO:0031639	insulin-like growth factor receptor binding;urokinase plasminogen activator receptor activity;transforming growth factor beta1 activation;plasminogen activation	None	None	10092105	Transforming growth factor- beta1 (TGF- beta1) is a critical cytokine for cell proliferation and differentiation. It is secreted by many cells in a latent pro-form (LTGF- beta1) from which biologically active TGF- beta1 is released. M6P/IGFII-R directly interacts with uPA-R and also binds Plg (plasminogen). Moreover, the M6P/IGFII-R - uPA-R complex can simultaneously recruit the ligands uPA, Plg and LTGF- beta1, and controls uPA-mediated activation of Plg to Plm for TGF-beta1 release. Plasmin generated from Plg in the complex mediates release of TGF-beta1 when M6P/IGFII-R is associated with uPA-R.	TGF-beta1 None mice exhibit a disastrous phenotype including multiorgan inflammatory syndrome, lack of Langerhans cells, progressive growth retardation and death by 4 weeks of age.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Plasminogen;Cation-independent mannose-6-phosphate receptor;Urokinase plasminogen activator surface receptor	PLG;IGF2R;PLAUR	None;MPRI;MO3 UPAR
7108	IGF2R-PLAUR complex	Human	MPRI-UPAR complex	U937 cells	P11717;Q03405	3482;5329	MI:0019-coimmunoprecipitation	GO:0005159	insulin-like growth factor receptor binding	None	None	10092105	A direct interaction between uPA-R and M6P/IGFII-R is demonstrated. This binding is independent of the GPI part of uPA-R. The binding of M6P/IGFII-R to uPA-R is neither mediated nor inhibited by uPA. Experiments indicate that neither ligationof M6P/IGFII-R nor ligation of uPA-R prevents their mutual interaction.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cation-independent mannose-6-phosphate receptor;Urokinase plasminogen activator surface receptor	IGF2R;PLAUR	MPRI;MO3 UPAR
7109	IGF2R-PLAUR-PLAU complex	Human	IGF2R-uPAR-uPA complex	human monocytes (PBMC); U937 cells	P00749;P11717;Q03405	5328;3482;5329	MI:0019-coimmunoprecipitation	GO:0005159;GO:0030377	insulin-like growth factor receptor binding;urokinase plasminogen activator receptor activity	None	None	10092105	It is shown that the mannose-6-phosphate/insulin-like growth factor II-receptor (M6P/IGFII-R), which binds LTGF- beta1, complexes with urokinase (plasminogen activator)-receptor (uPA-R) on the surface of human monocytes and directly binds plasminogen (Plg). Plasmin generated from Plg in the complex mediates release of TGF- beta1 when M6P/IGFII-R is associated with uPA-R. Thus, this interaction of M6P/IGFII-R and uPA-R suggests a potential mechanism for the generation of TGF- beta1 by cells. The M6P/IGFII-R-uPAR complex can simultaneously recruit the ligands uPA (Urokinase plasminogen activator), Plg (Plasminogen) and LTGF-beta1 (Latent transforming growth factor-beta1), and controls uPA-mediated activation of Plg to Plm for TGF-beta1 release.	TGF-beta1 None mice exhibit a disastrous phenotype including multiorgan inflammatory syndrome, lack of Langerhans cells, progressive growth retardation and death by 4 weeks of age.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Urokinase-type plasminogen activator;Cation-independent mannose-6-phosphate receptor;Urokinase plasminogen activator surface receptor	PLAU;IGF2R;PLAUR	None;MPRI;MO3 UPAR
7110	IGF2R-PLG-PLAU-PLAUR-LTGFbeta1 complex	Human	IGF2R-PLG-uPA-uPAR-LTGFbeta1 complex	human monocytes (PBMC); U937 cells	P00747;P00749;P01137;P11717;Q03405	5340;5328;7040;3482;5329	MI:0019-coimmunoprecipitation	GO:0005159;GO:0031639;GO:0036364;GO:0030377	insulin-like growth factor receptor binding;plasminogen activation;transforming growth factor beta1 activation;urokinase plasminogen activator receptor activity	None	None	10092105	It is shown in this study that M6P/IGFII-R (IGF2R) and uPAR (PLAUR) are associated at the surface of human monocytes, and that this complex can simultaneously bind LTGF-beta1,Plg (Plaminogen) and uPA (PLAU). It was found that the controlledgeneration of Plm (Plasmin) from Plg in this complex mediatesrelease of active TGF-beta1 from LTGF-beta1.	TGF-beta1 None mice exhibit a disastrous phenotype including multiorgan inflammatory syndrome, lack of Langerhans cells, progressive growth retardation and death by 4 weeks of age.	As the inactive pro-form LTGF-beta1 (= TGF-beta1 + LAP) is not given in UniProt, the biologically active TGF-beta1 (= TGF-beta1 without LAP) is used for annotation. M6P/IGFII-R binds via a distinct site Plasminogen (PLG) and enables uPA-mediated conversion of PLG to Plasmin (PLM). PLM generated from PLG in the IGF2R-PLG-LTGF-beta1 complex mediates the release of active TGF- beta1 when M6P/IGFII-R is associated with uPAR (PLAUR) and its ligand uPA (PLAU).	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Plasminogen;Urokinase-type plasminogen activator;Transforming growth factor beta-1 proprotein;Cation-independent mannose-6-phosphate receptor;Urokinase plasminogen activator surface receptor	PLG;PLAU;TGFB1;IGF2R;PLAUR	None;None;TGFB;MPRI;MO3 UPAR
7111	NUFIP2-Roquin1 complex	Human	NUFIP2-RC3H1 complex	in HEK293T cells	Q5TC82;Q7Z417	149041;57532	MI:0007-anti tag coimmunoprecipitation	GO:0031295;GO:0006402	T cell costimulation;mRNA catabolic process	None	None	29352114	NUFIP2 increases the binding affinity of Roquin1 (RC3H1) in a ternary complex with ICOS 3'-UTR.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Roquin-1;FMR1-interacting protein NUFIP2	RC3H1;NUFIP2	KIAA2025,RNF198;KIAA1321
7112	PLAUR-PLAU complex	Human	uPAR-uPA complex	human monocytes (PBMC); U937 cells	P00749;Q03405	5328;5329	MI:0047-far western blotting	GO:0030377;GO:0031639	urokinase plasminogen activator receptor activity;plasminogen activation	None	None	10092105	The natural ligand of uPAR is uPA. uPAR-bound uPA converts Plasminogen into Plasmin by proteolytic cleavage atamino acid Arg560-Val561.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Urokinase-type plasminogen activator;Urokinase plasminogen activator surface receptor	PLAU;PLAUR	None;MO3 UPAR
7113	ABRAXAS2-SHMT1 complex	Human	KIAA0157-SHMT1 complex	HeLa S3 cells	P34896;Q15018	6470;23172	MI:0019-coimmunoprecipitation	GO:0016579	protein deubiquitination	14.07.05	modification by ubiquitination, deubiquitination	24075985	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Serine hydroxymethyltransferase, cytosolic;BRISC complex subunit Abraxas 2	SHMT1;ABRAXAS2	None;ABRO1,FAM175B,KIAA0157
7114	ABRAXAS2-SHMT2 complex	Human	KIAA0157-SHMT2 complex	HeLa S3 cells	P34897;Q15018	6472;23172	MI:0019-coimmunoprecipitation	GO:0016579;GO:0035457	protein deubiquitination;cellular response to interferon-alpha	14.07.05	modification by ubiquitination, deubiquitination	24075985	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Serine hydroxymethyltransferase, mitochondrial;BRISC complex subunit Abraxas 2	SHMT2;ABRAXAS2	None;ABRO1,FAM175B,KIAA0157
7116	GRB7-PTK2 complex	Human	GRB7-FAK complex	plasma fibronectin; transfected CHO cells	Q05397;Q14451	5747;2886	MI:0019-coimmunoprecipitation;MI:0047-far western blotting;MI:0096-pull down	GO:0016477	cell migration	34.05.01	cell migration	10446223	Focal adhesion kinase (FAK/Ptk2) is a cytoplasmic tyrosine kinase that has been shown to play a critical role in integrin-mediated signal transduction. Grb7 is a member of signaling proteins that include Grb7, Grb10, and Grb14. The family members have a highly conserved structure: the NH2-terminal region has proline-rich motifs, the central region has a pleckstrin homology (PH) domain, and the COOH-terminal region has an SH2 domain. Consistent with their domain structures, Grb7 family proteins have been shown to interact with a variety ofother proteins, including tyrosine kinase receptors and protooncogenes. These interactions are believed to play arole in the regulation of mitogenic signaling pathways. It is shown that the SH2 domain of Grb7 can directly interact with FAK through Tyr-397, a major autophosphorylation site invitro and in vivo. This interaction is cell adhesion-dependent,suggesting that the FAK-Grb7 complex is involved in integrin signaling. Overexpression of Grb7 enhanced cell migration toward fibronectin, whereas overexpression of its SH2 domain alone inhibited cell migration.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Focal adhesion kinase 1;Growth factor receptor-bound protein 7	PTK2;GRB7	FAK, FAK1;None
7122	TIM23(motor) subcomplex (GRPEL1, GRPEL2, HSPA9), mitochondrial	Human	mtHsp70-GrpEL1-GrpEL2 complex; HSPA9-GRPEL1-GRPEL2 complex	HeLa cells; HEK293T cells	P38646;Q8TAA5;Q9HAV7	3313;134266;80273	MI:0019-coimmunoprecipitation	GO:0031072;GO:0030150;GO:0001405;GO:0006839;GO:0005739;GO:0006626	heat shock protein binding;protein import into mitochondrial matrix;PAM complex, Tim23 associated import motor;mitochondrial transport;mitochondrion;protein targeting to mitochondrion	20.09.04;70.16	mitochondrial transport;mitochondrion	28848044	Most mitochondrial proteins are nuclearly encoded and are imported into the matrix compartment where they are properly folded. This process is facilitated by the mitochondrial heat shock protein 70 (mtHsp70), a chaperone contributing to mitochondrial protein quality control. Nucleotide exchange factors (NEFs) play a crucial role in exchanging ADP for ATP at mtHsp70's nucleotide-binding domain, thereby modulating mtHsp70's chaperone activity. Two putative NEF orthologs, GrpE-like 1 (GrpEL1) and GrpEL2, are reported that modulate mtHsp70's function in human cells. Both GrpEL1 and GrpEL2 associate with mtHsp70 as a hetero-oligomeric subcomplex and regulate mtHsp70 function. The formation of this subcomplex was critical for conferring stability to the NEFs, helped fine-tune mitochondrial protein quality control, and regulated crucial mtHsp70 functions, such as import of preproteins and biogenesis of Fe-S clusters (PMID:28848044).The TIM23 complex is anchored to the inner mitochondrial membrane (IMM) and exists as a hetero-oligomeric complex, composed of various subunits. It consists of an integral membrane embedded core complex as well as an import motor. The core complex contains three essential subunits named TIM17A/B, TIM23, and TIM50. Additionally, the membrane-embedded part has the two non-essential subunits TIM21 and ROMO1. The import motor, also known as the presequence translocase-associated motor (PAM) complex, drives translocation across the IMM, aided by ATP hydrolysis, and consists of TIM44, mtHSP70, DNAJC15/19, TIM16, and GRPEL1/2 (PMID: 34064758).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Stress-70 protein, mitochondrial;GrpE protein homolog 2, mitochondrial;GrpE protein homolog 1, mitochondrial	HSPA9;GRPEL2;GRPEL1	GRP75 HSPA9B mt-HSP70;None;GREPEL1
7123	TIM23(motor) subcomplex (GRPEL1, GRPEL2), mitochondrial	Human	GrpEL1-GrpEL2 complex; PAM subcomplex (GrpEL1, GrpEL2)	HeLa cells; HEK293T cells	Q8TAA5;Q9HAV7	134266;80273	MI:0013-biophysical;MI:0019-coimmunoprecipitation;MI:0047-far western blotting;MI:0276-blue native page	GO:0031072;GO:0030150;GO:0001405;GO:0005739;GO:0006839;GO:0006626	heat shock protein binding;protein import into mitochondrial matrix;PAM complex, Tim23 associated import motor;mitochondrion;mitochondrial transport;protein targeting to mitochondrion	70.16;20.09.04	mitochondrion;mitochondrial transport	28848044	Most mitochondrial proteins are nuclearly encoded and are imported into the matrix compartment where they are properly folded. This process is facilitated by the mitochondrial heat shock protein 70 (mtHsp70), a chaperone contributing to mitochondrial protein quality control. Nucleotide exchange factors (NEFs) play a crucial role in exchanging ADP for ATP at mtHsp70's nucleotide-binding domain, thereby modulating mtHsp70's chaperone activity. Two putative NEF orthologs, GrpE-like 1 (GrpEL1) and GrpEL2, are reported that modulate mtHsp70's function in human cells. Both GrpEL1 and GrpEL2 associate with mtHsp70 as a hetero-oligomeric subcomplex and regulate mtHsp70 function. The formation of this subcomplex was critical for conferring stability to the NEFs, helped fine-tune mitochondrial protein quality control, and regulated crucial mtHsp70 functions, such as import of preproteins and biogenesis of Fe-S clusters. The direct interaction between EL1 and EL2 was determined by biolayer interferometry (PMID:28848044).The TIM23 complex is anchored to the inner mitochondrial membrane (IMM) and exists as a hetero-oligomeric complex, composed of various subunits. It consists of an integral membrane embedded core complex as well as an import motor. The core complex contains three essential subunits named TIM17A/B, TIM23, and TIM50. Additionally, the membrane-embedded part has the two non-essential subunits TIM21 and ROMO1. The import motor, also known as the presequence translocase-associated motor (PAM) complex, drives translocation across the IMM, aided by ATP hydrolysis, and consists of TIM44, mtHSP70, DNAJC15/19, TIM16, and GRPEL1/2 (PMID: 34064758).	None	None	Homo sapiens (Human);Homo sapiens (Human)	GrpE protein homolog 2, mitochondrial;GrpE protein homolog 1, mitochondrial	GRPEL2;GRPEL1	None;GREPEL1
7124	TIM23(motor) subcomplex (GRPEL1, HSPA9), mitochondrial	Human	mtHsp70-GrpEL1 complex; PAM subcomplex (HSPA9, GRPEL1)	HeLa cells; HEK293T cells	P38646;Q9HAV7	3313;80273	MI:0013-biophysical	GO:0031072;GO:0030150;GO:0001405;GO:0006839;GO:0005739;GO:0006626	heat shock protein binding;protein import into mitochondrial matrix;PAM complex, Tim23 associated import motor;mitochondrial transport;mitochondrion;protein targeting to mitochondrion	20.09.04;70.16	mitochondrial transport;mitochondrion	28848044	Most mitochondrial proteins are nuclearly encoded and are imported into the matrix compartment where they are properly folded. This process is facilitated by the mitochondrial heat shock protein 70 (mtHsp70), a chaperone contributing to mitochondrial protein quality control. Nucleotide exchange factors (NEFs) play a crucial role in exchanging ADP for ATP at mtHsp70's nucleotide-binding domain, thereby modulating mtHsp70's chaperone activity. Two putative NEF orthologs, GrpE-like 1 (GrpEL1) and GrpEL2, are reported that modulate mtHsp70's function in human cells. Both GrpEL1 and GrpEL2 associate with mtHsp70 as a hetero-oligomeric subcomplex and regulate mtHsp70 function. The formation of this subcomplex was critical for conferring stability to the NEFs, helped fine-tune mitochondrial protein quality control, and regulated crucial mtHsp70 functions, such as import of preproteins and biogenesis of Fe-S clusters (PMID:28848044).The TIM23 complex is anchored to the inner mitochondrial membrane (IMM) and exists as a hetero-oligomeric complex, composed of various subunits. It consists of an integral membrane embedded core complex as well as an import motor. The core complex contains three essential subunits named TIM17A/B, TIM23, and TIM50. Additionally, the membrane-embedded part has the two non-essential subunits TIM21 and ROMO1. The import motor, also known as the presequence translocase-associated motor (PAM) complex, drives translocation across the IMM, aided by ATP hydrolysis, and consists of TIM44, mtHSP70, DNAJC15/19, TIM16, and GRPEL1/2 (PMID:34064758).	None	None	Homo sapiens (Human);Homo sapiens (Human)	Stress-70 protein, mitochondrial;GrpE protein homolog 1, mitochondrial	HSPA9;GRPEL1	GRP75 HSPA9B mt-HSP70;GREPEL1
7125	TIM23(motor) subcomplex (GRPEL2, HSPA9), mitochondrial	Human	mtHsp70-GrpEL2 complex; PAM subcomplex (GRPEL2, HSPA9)	HeLa cells; HEK293T cells	P38646;Q8TAA5	3313;134266	MI:0013-biophysical	GO:0031072;GO:0030150;GO:0001405;GO:0005739;GO:0006839;GO:0006626	heat shock protein binding;protein import into mitochondrial matrix;PAM complex, Tim23 associated import motor;mitochondrion;mitochondrial transport;protein targeting to mitochondrion	70.16;20.09.04	mitochondrion;mitochondrial transport	28848044	Most mitochondrial proteins are nuclearly encoded and are imported into the matrix compartment where they are properly folded. This process is facilitated by the mitochondrial heat shock protein 70 (mtHsp70), a chaperone contributing to mitochondrial protein quality control. Nucleotide exchange factors (NEFs) play a crucial role in exchanging ADP for ATP at mtHsp70's nucleotide-binding domain, thereby modulating mtHsp70's chaperone activity. Two putative NEF orthologs, GrpE-like 1 (GrpEL1) and GrpEL2, are reported that modulate mtHsp70's function in human cells. Both GrpEL1 and GrpEL2 associate with mtHsp70 as a hetero-oligomeric subcomplex and regulate mtHsp70 function. The formation of this subcomplex was critical for conferring stability to the NEFs, helped fine-tune mitochondrial protein quality control, and regulated crucial mtHsp70 functions, such as import of preproteins and biogenesis of Fe-S clusters (PMID:28848044).The TIM23 complex is anchored to the inner mitochondrial membrane (IMM) and exists as a hetero-oligomeric complex, composed of various subunits. It consists of an integral membrane embedded core complex as well as an import motor. The core complex contains three essential subunits named TIM17A/B, TIM23, and TIM50. Additionally, the membrane-embedded part has the two non-essential subunits TIM21 and ROMO1. The import motor, also known as the presequence translocase-associated motor (PAM) complex, drives translocation across the IMM, aided by ATP hydrolysis, and consists of TIM44, mtHSP70, DNAJC15/19, TIM16, and GRPEL1/2 (PMID: 34064758).	None	None	Homo sapiens (Human);Homo sapiens (Human)	Stress-70 protein, mitochondrial;GrpE protein homolog 2, mitochondrial	HSPA9;GRPEL2	GRP75 HSPA9B mt-HSP70;None
7126	TIM23(motor) subcomplex (GRPEL1, GRPEL2, HSPA9, TIMM44), mitochondrial	Human	PAM subcomplex (GRPEL1, GRPEL2, HSPA9, TIMM44), mitochondrial; TIM23motor subcomplex (mtHsp70, GrpEL1, GrpEL2, TIM44)	HeLa cells; HEK293T cells	O43615;P38646;Q8TAA5;Q9HAV7	10469;3313;134266;80273	MI:0019-coimmunoprecipitation	GO:0031072;GO:0030150;GO:0001405;GO:0005739;GO:0006839;GO:0006626	heat shock protein binding;protein import into mitochondrial matrix;PAM complex, Tim23 associated import motor;mitochondrion;mitochondrial transport;protein targeting to mitochondrion	70.16;20.09.04	mitochondrion;mitochondrial transport	28848044	The mitochondrial import motor consists of chaperone mtHsp70 as the core component together with a heterodimer of cochaperones J-proteins/J-like proteins, NEF (Nucleotide exchange factors), and scaffold protein Tim44. Because interaction of NEF-mtHsp70-Tim44 complex is known to be ATP-sensitive in nature, the coIP was performed in the presence of 2mM ATP. Addition of ATP in the immunoprecipitates resulted in the dissociation of mtHsp70 and Tim44, but the EL1-EL2 subcomplex remained stable, indicating that in humans the NEF paralogs associate with the import motor as a hetero-subcomplex (PMID:28848044). The TIM23 complex is anchored to the inner mitochondrial membrane (IMM) and exists as a hetero-oligomeric complex, composed of various subunits. It consists of an integral membrane embedded core complex as well as an import motor. The core complex contains three essential subunits named TIM17A/B, TIM23, and TIM50. Additionally, the membrane-embedded part has the two non-essential subunits TIM21 and ROMO1. The import motor, also known as the presequence translocase-associated motor (PAM) complex, drives translocation across the IMM, aided by ATP hydrolysis, and consists of TIM44, mtHSP70, DNAJC15/19, TIM16, and GRPEL1/2 (PMID: 34064758).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mitochondrial import inner membrane translocase subunit TIM44;Stress-70 protein, mitochondrial;GrpE protein homolog 2, mitochondrial;GrpE protein homolog 1, mitochondrial	TIMM44;HSPA9;GRPEL2;GRPEL1	MIMT44, TIM44;GRP75 HSPA9B mt-HSP70;None;GREPEL1
7127	GSKIP-GSK3B-PRKAR2A complex	Human	GSKIP-GSK3B-PKA(R2alpha) complex	HEK293 cells;  A549 cells; HeLa cells	P13861;P49841;Q9P0R6	5576;2932;51527	MI:0019-coimmunoprecipitation	GO:0016055;GO:0006468;GO:0060828	Wnt signaling pathway;protein phosphorylation;regulation of canonical Wnt signaling pathway	30.05.02.20;14.07.03	Wnt signalling pathway;modification by phosphorylation, dephosphorylation, autophosphorylation	27484798	A cytoplasmic destruction complex targets beta-catenin for degradation and thus prevents Wnt signaling. Wnt signals cause beta-catenin accumulation and translocation into the nucleus, where it induces Wnt target gene expression.GSKIP facilitates control of the beta-catenin stabilizing phosphorylation at Ser-675 by PKA.GSKIP directly binds GSK3beta and PKA. It controls the stability of beta-catenin and thus its transcriptional activity through facilitating its phosphorylation by the two kinases. GSK3beta phosphorylates Ser-33/Ser-37/Thr-41 in the cytoplasm and targets it for proteasomal degradation. The phosphorylation of Ser-675 by PKA stabilizes beta-catenin and enhances Wnt-induced signaling. GSKIP, regulatory RII alpha subunits of PKA, and HSP90 (as a control) were detected by Western blotting.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	cAMP-dependent protein kinase type II-alpha regulatory subunit;Glycogen synthase kinase-3 beta;GSK3B-interacting protein	PRKAR2A;GSK3B;GSKIP	PKR2, PRKAR2;None;C14orf129
7129	GSKIP-PRKAR2B complex	Human	GSKIP-PKARIIB complex	SH-SY5Y cells; HEK293 cells	P31323;Q9P0R6	5577;51527	MI:0107-surface plasmon resonance	GO:0006468	protein phosphorylation	14.07.03	modification by phosphorylation, dephosphorylation, autophosphorylation	20007971	GSKIP contains the domain of unknown function 727 (DUF727). DUF727 covers almost the entire sequence of human GSKIP (amino acids 32\u2013139) and confers the ability to interact with both RII (amino acids 28\u201352) and GSK3B (amino acids 115\u2013139). GSKIP binds RII subunits withnanomolar affinities in Biacore measurements (RIIalpha with KD = 5 nM and RIIbeta with KD = 43 nM). It is apparently an RII-specific AKAP because binding of RI subunits was not detectable in Biacore experiments.	None	None	Homo sapiens (Human);Homo sapiens (Human)	cAMP-dependent protein kinase type II-beta regulatory subunit;GSK3B-interacting protein	PRKAR2B;GSKIP	None;C14orf129
7130	PRKAR2A-GSKIP-GSK3B-DNM1L complex	Human	PKA/GSKIP/GSK3B/DRP1 complex	SH-SY5Y cells; HeLa cells; HEK293 cells	O00429;P13861;P49841;Q9P0R6	10059;5576;2932;51527	MI:0019-coimmunoprecipitation	GO:0070125;GO:0006979;GO:0006468	mitochondrial translational elongation;response to oxidative stress;protein phosphorylation	32.01.01;14.07.03	oxidative stress response;modification by phosphorylation, dephosphorylation, autophosphorylation	25920809	GSKIP and GSK3B play central roles in the cAMP/PKA/GSKIP/GSK/Drp1 axis signaling that causes mitochondrial elongation under oxidative stress GSKIP- and GSK3-mediated anchoring strengthens cAMP/PKA/Drp1 axis signaling in the regulation of mitochondrial elongation by forming a working complex comprising PKA/GSKIP/GSK3B/Drp1. Both GSKIP and GSK3B function as anchoring proteins in the cAMP/PKA/Drp1 signaling axis modulating Drp1 phosphorylation.	The PKA/GSKIP/GSK3/Drp1 axis and the PKA signaling pathways are involved in the pathogenesis of neurodegenerative diseases.	Since the authors did not specify the regulatory subunit of PKA RII (alpha or beta), we used isoform PRKAR2A (alpha).	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Dynamin-1-like protein;cAMP-dependent protein kinase type II-alpha regulatory subunit;Glycogen synthase kinase-3 beta;GSK3B-interacting protein	DNM1L;PRKAR2A;GSK3B;GSKIP	DLP1 DRP1;PKR2, PRKAR2;None;C14orf129
7131	COMMD1-CCDC22-CCDC93-C16orf62 complex	Human	None	HEK293T cell	O60826;Q567U6;Q7Z3J2;Q8N668	28952;54520;57020;150684	MI:0019-coimmunoprecipitation	GO:0055070;GO:0005769	copper ion homeostasis;early endosome	None	None	25355947	COMMD1 is directly linked to early endosomes through its interaction with a protein complex containing CCDC22, CCDC93, and C16orf62. CCDC22/CCDC93/COMMD1 interactions are not dependent on C16orf62.	COMMD1 deficiency results in defective copper homeostasis.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Coiled-coil domain-containing protein 22;Coiled-coil domain-containing protein 93;VPS35 endosomal protein-sorting factor-like;COMM domain-containing protein 1	CCDC22;CCDC93;VPS35L;COMMD1	CXorf37;None;C16orf62;C2orf5, MURR1
7132	CCDC22-CCDC93-C16orf62 complex	Human	None	HEK293T cell	O60826;Q567U6;Q7Z3J2	28952;54520;57020	MI:0019-coimmunoprecipitation	GO:0005768;GO:0055070	endosome;copper ion homeostasis	70.22	endosome	25355947	Coimmunoprecipitation of endogenous CCDC22, CCDC93, and C16orf62 in HEK293T cell lysates confirm their interactions.  The carboxyl-terminal ends of CCDC22 and CCDC93 are responsible for CCC complex recruitment to endosomes.	Depletion of CCC complex components leads to lack of copper-dependent movement of the copper transporter ATP7A from endosomes, resulting in intracellular copper accumulation and modest alterations in copper homeostasis in humans with CCDC22 mutations.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Coiled-coil domain-containing protein 22;Coiled-coil domain-containing protein 93;VPS35 endosomal protein-sorting factor-like	CCDC22;CCDC93;VPS35L	CXorf37;None;C16orf62
7133	CCDC93-COMMD1-COMMD6 complex	Human	None	HEK293T cells	Q567U6;Q7Z4G1;Q8N668	54520;170622;150684	MI:0019-coimmunoprecipitation	GO:0055070;GO:0005769	copper ion homeostasis;early endosome	None	None	25355947	COMMD1 is directly linked to early endosomes through its interaction with a protein complex. Immunoprecipitation of endogenous CCDC93 resulted in the coprecipitation of endogenous COMMD1 and COMMD6 but not IKK1 6 in HEK293T cell lysates.	COMMD1 deficiency results in defective copper homeostasis.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Coiled-coil domain-containing protein 93;COMM domain-containing protein 6;COMM domain-containing protein 1	CCDC93;COMMD6;COMMD1	None;None;C2orf5, MURR1
7134	COMMD1-CCDC93-C16orf62 complex	Human	None	HEK293 cells	Q567U6;Q7Z3J2;Q8N668	54520;57020;150684	MI:0019-coimmunoprecipitation	GO:0055070;GO:0005769	copper ion homeostasis;early endosome	None	None	5355947	COMMD1 is directly linked to early endosomes through its interaction with a protein complex. Endogenous COMMD1 coimmunoprecipitates with C16orf62 and CCDC93 in HEK293 cell lysates.	COMMD1 deficiency results in defective copper homeostasis.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Coiled-coil domain-containing protein 93;VPS35 endosomal protein-sorting factor-like;COMM domain-containing protein 1	CCDC93;VPS35L;COMMD1	None;C16orf62;C2orf5, MURR1
7135	CCDC22-CCDC93-C16orf62-FAM21-WASH1 complex	Human	CCC subunits (CCDC22, CCDC93, C16orf62) -  WASH components (FAM21,WASH1) complex	HeLa cells	A8K0Z3;O60826;Q567U6;Q7Z3J2;Q9Y4E1	100287171;28952;54520;57020;253725	MI:0019-coimmunoprecipitation;MI:0107-surface plasmon resonance	GO:0005768	endosome	70.22	endosome	25355947	Interactions betweenthe WASH complex subunit FAM21, and the carboxyl-terminal ends of CCDC22 and CCDC93 are responsible for CCC complex recruitment to endosomes.  Coimmunoprecipitation of endogenous CCC subunits (CCDC22, CCDC93, and C16orf62) with the WASH components (FAM21 and WASH) was noted using HeLa cell lysates. The C-terminus of CCDC93 can make a direct and high-affinity interaction with the N-terminal tail region of FAM21.	None	Since the authors did not specify FAM21, we used isoform FAM21C.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	WASH complex subunit 1;Coiled-coil domain-containing protein 22;Coiled-coil domain-containing protein 93;VPS35 endosomal protein-sorting factor-like;WASH complex subunit 2C	WASHC1;CCDC22;CCDC93;VPS35L;WASHC2C	FAM39E WASH1;CXorf37;None;C16orf62;FAM21C KIAA0592 VPEF
7136	VCP-SELK-DERL1 complex	Human	p97-SELENOK-DERL1 complex	HEK 293 cell	P55072;Q9BUN8;Q9Y6D0	7415;79139;58515	MI:0007-anti tag coimmunoprecipitation	GO:0030968;GO:0036503	endoplasmic reticulum unfolded protein response;ERAD pathway	32.01.07	unfolded protein response (e.g. ER quality control)	22016385	SelK has higher affinity for Derlin-1, whereas SelS has higher affinity for Derlin-2. This suggests that the selenoproteins SelK and SelS could determine the nature of the substrate translocated through the Derlin channel.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transitional endoplasmic reticulum ATPase;Derlin-1;Selenoprotein K	VCP;DERL1;SELENOK	None;DER1;SELK
7139	SEC23-SEC24 adaptor complex	Human	SEC23/24 adaptor complex; COPII coat component	human epithelial colorectal adenocarcinoma Caco-2/15 cells	O95487;Q15436	10427;10484	MI:0019-coimmunoprecipitation	GO:0097020;GO:0048208;GO:0005783	COPII receptor activity;COPII vesicle coating;endoplasmic reticulum	70.07	endoplasmic reticulum	21836065	COPII coats are assembled from 3 components, ie, Sar1b, Sec23/24, and Sec13/31 complexes, necessary to capture cargo proteins and sculpt the ER membrane into vesicles. GTP loaded Sar1b recruits the cargo adaptor complex Sec23/Sec24 to ER exit domains.	None	Since the authors did not specify SEC24 (a,b,c,or d), we used the longest isoform SEC24B.	Homo sapiens (Human);Homo sapiens (Human)	Protein transport protein Sec24B;Protein transport protein Sec23A	SEC24B;SEC23A	None;None
7140	SEC23-SEC24-SCAP-SREBP1c complex	Human	(Sec23/24 adapter)-(SCAP/SREBP1c) complex	human epithelial colorectal adenocarcinoma Caco-2/15 cells	O95487;P36956;Q12770;Q15436	10427;6720;22937;10484	MI:0019-coimmunoprecipitation	GO:0097020;GO:0048208;GO:0051169;GO:0006629;GO:0005783	COPII receptor activity;COPII vesicle coating;nuclear transport;lipid metabolic process;endoplasmic reticulum	20.09.01;01.06;70.07	nuclear transport;lipid, fatty acid and isoprenoid metabolism;endoplasmic reticulum	21836065	Coimmunoprecipitation studies in microsomes isolated from Caco-2/15 cells with Sar1b overexpression documented a pronounced interaction of Sec23/Sec24 with sterol regulatory element binding protein (SREBP) cleavage-activating protein and SREBP-1c, thereby permitting the transfer of the transcription factor SREBP-1c to the nucleus for the activation of genes involved in lipid metabolism.	None	Since the authors did not specify SEC24 (a,b,c,or d), we used the longest isoform SEC24B. Alternative promoter usage and splicing of gene SREBF1 result in several transcript variants, including SREBP-1c (mentioned in this paper).	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein transport protein Sec24B;Sterol regulatory element-binding protein 1;Sterol regulatory element-binding protein cleavage-activating protein;Protein transport protein Sec23A	SEC24B;SREBF1;SCAP;SEC23A	None;BHLHD1, SREBP1;KIAA0199;None
7141	Coat protein complex II (SAR1B, PREB, SEC23A , SEC24B, SEC23IP)	Human	COPII (SAR1B, SEC12, SEC23A, SEC24B, p125)	human epithelial colorectal adenocarcinoma Caco-2/15 cells	O95487;Q15436;Q9HCU5;Q9Y6B6;Q9Y6Y8	10427;10484;10113;51128;11196	MI:0019-coimmunoprecipitation	GO:0097020;GO:0048208;GO:0005783	COPII receptor activity;COPII vesicle coating;endoplasmic reticulum	70.07	endoplasmic reticulum	21836065	Sar1b plays a significant role in the assembly, organization, and function of the coat protein complex II (COPII), a critical complex for the transport of proteins from the endoplasmic reticulum to the Golgi. Along with the enhanced chylomicrons, microsomes were characterized by abundant Sec12, the guanine exchange factor that promotes the localization of Sar1b in the endoplasmic reticulum. Coimmunoprecipitation experiments revealed high levels of the complex components Sec23/Sec24 and p125, the Sec23-interacting protein.	Although 2 isoforms characterize Sar1, only Sar1b hasbeen associated with the rare recessive disorder CRD,characterized by the selective retention of CM-like particleswithin the ER of enterocytes.	Since the authors did not specify SEC24 (a,b,c,or d), we used the longest isoform SEC24B.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein transport protein Sec24B;Protein transport protein Sec23A;Prolactin regulatory element-binding protein;GTP-binding protein SAR1b;SEC23-interacting protein	SEC24B;SEC23A;PREB;SAR1B;SEC23IP	None;None;SEC12;SARA2 SARB;None
7143	GNAS-L-GNB2-GNG1 complex	Human	G-protein alpha(s)-L-beta2-gamma1 complex	None	P62879;P63092;P63211	2783;2778;2792	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2;Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(T) subunit gamma-T1	GNB2;GNAS;GNGT1	None;GNAS1 GSP;None
7144	GNAS-L-GNB3-GNG1 complex	Human	G-protein alpha(s)-L-beta3-gamma1 complex	None	P16520;P63092;P63211	2784;2778;2792	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3;Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(T) subunit gamma-T1	GNB3;GNAS;GNGT1	None;GNAS1 GSP;None
7145	GNAS-L-GNB4-GNG1 complex	Human	G-protein alpha(s)-L-beta4-gamma1 complex	None	P63092;P63211;Q9HAV0	2778;2792;59345	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(T) subunit gamma-T1;Guanine nucleotide-binding protein subunit beta-4	GNAS;GNGT1;GNB4	GNAS1 GSP;None;None
7146	GNAS-L-GNB1-GNG1 complex	Human	G-protein alpha(s)-L-beta5-gamma1 complex	None	O14775;P63092;P63211	10681;2778;2792	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein subunit beta-5;Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(T) subunit gamma-T1	GNB5;GNAS;GNGT1	None;GNAS1 GSP;None
7148	GNAS-L-GNB2-GNG2 complex	Human	G-protein alpha(s)-L-beta2-gamma2 complex	None	P59768;P62879;P63092	54331;2783;2778	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2;Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNG2;GNB2;GNAS	None;None;GNAS1 GSP
7149	GNAS-L-GNB3-GNG2 complex	Human	G-protein alpha(s)-L-beta3-gamma2 complex	None	P16520;P59768;P63092	2784;54331;2778	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2;Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNB3;GNG2;GNAS	None;None;GNAS1 GSP
7150	GNAS-L-GNB4-GNG2 complex	Human	G-protein alpha(s)-L-beta4-gamma2 complex	None	P59768;P63092;Q9HAV0	54331;2778;59345	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2;Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein subunit beta-4	GNG2;GNAS;GNB4	None;GNAS1 GSP;None
7151	GNAS-L-GNB4-GNG2 complex	Human	G-protein alpha(s)-L-beta5-gamma2 complex	None	O14775;P59768;P63092	10681;54331;2778	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein subunit beta-5;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2;Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNB5;GNG2;GNAS	None;None;GNAS1 GSP
7152	GNAS-L-GNB1-GNG3 complex	Human	G-protein alpha(s)-L-beta1-gamma3 complex	None	P62873;P63092;P63215	2782;2778;2785	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	GNB1;GNAS;GNG3	None;GNAS1 GSP;GNGT3
7153	GNAS-L-GNB2-GNG3 complex	Human	G-protein alpha(s)-L-beta2-gamma3 complex	None	P62879;P63092;P63215	2783;2778;2785	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2;Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	GNB2;GNAS;GNG3	None;GNAS1 GSP;GNGT3
7154	GNAS-L-GNB1-GNG3 complex	Human	G-protein alpha(s)-L-beta3-gamma3 complex	None	P16520;P63092;P63215	2784;2778;2785	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3;Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	GNB3;GNAS;GNG3	None;GNAS1 GSP;GNGT3
7155	GNAS-L-GNB4-GNG3 complex	Human	G-protein alpha(s)-L-beta4-gamma3 complex	None	P63092;P63215;Q9HAV0	2778;2785;59345	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3;Guanine nucleotide-binding protein subunit beta-4	GNAS;GNG3;GNB4	GNAS1 GSP;GNGT3;None
7156	GNAS-L-GNB5-GNG3 complex	Human	G-protein alpha(s)-L-beta5-gamma3 complex	None	O14775;P63092;P63215	10681;2778;2785	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein subunit beta-5;Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	GNB5;GNAS;GNG3	None;GNAS1 GSP;GNGT3
7157	TSC1-TSC2 complex	Human	None	HEK293T cells	P49815;Q92574	7249;7248	MI:0019-coimmunoprecipitation	GO:1904713;GO:0033596;GO:0009299;GO:0030111;GO:0042325;GO:0006417	beta-catenin destruction complex binding;TSC1-TSC2 complex;mRNA transcription;regulation of Wnt signaling pathway;regulation of phosphorylation;regulation of translation	11.02.03;12.07	mRNA synthesis;translational control	15972957	GSK3 phosphorylates TSC1 and mediates TSC1-TSC2 interaction. TSC1/TSC2 complex associated with GSK3 and Axin promotes beta-catenin degradation to inhibit Wnt-stimulated TCF/LEF-dependent transcription (PMID:15972957). TSC1 and TSC2 form a functional complex and inhibit the phosphorylation of S6K and 4EBP1, two key regulators of translation (PMID:14651849).	Angiomyolipomas (AML), Lymphangioleiomyomatosis (LAM);Mutations in either the TSC1 or TSC2 tumor suppressor gene are responsible for Tuberous Sclerosis Complex (PMID:14651849)	None	Homo sapiens (Human);Homo sapiens (Human)	Tuberin;Hamartin	TSC2;TSC1	TSC4;KIAA0243, TSC
7158	TSC2-DVL complex	Human	TSC2-Dsh complex	HEK293T cells	O14640;P49815	1855;7249	MI:0019-coimmunoprecipitation	GO:0033596;GO:0030111	TSC1-TSC2 complex;regulation of Wnt signaling pathway	None	None	15972957	Dsh/DVL1 associates with TSC2 but not TSC1. The interaction between TSC2 and TSC1 or Dsh appeared to be mutually exclusive. In the presence of all three proteins, TSC2 preferentially associated with TSC1.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Segment polarity protein dishevelled homolog DVL-1;Tuberin	DVL1;TSC2	None;TSC4
7159	TSC2-GSK3-AXIN-DVL complex	Human	TSC2-GSK3-AXIN-Dsh complex	HEK293T cells	O14640;O15169;P49815;P49841	1855;8312;7249;2932	MI:0019-coimmunoprecipitation	GO:0030111;GO:0033596	regulation of Wnt signaling pathway;TSC1-TSC2 complex	None	None	15972957	In the absence of Wnt, tuberin (TSC2) co-immunoprecipitated GSK3, Axin, and to a minimal extent, Dsh/DVL1. On Wnt stimulation, significantly more tuberin was associated with Dsh but the amount of GSK3 or Axin associated with TSC2 decreased significantly. The inverse relationship of tuberin interaction between Dsh and GSK3/Axin is consistent with the putative role of Dsh in promoting the disassembly of the beta-catenin degradation complex and in doing so, associating with TSC2.	None	Since the authors did not specify GSK3 and Dsh/DVL, we used isoforms GSK3B and DVL1, respectively.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Segment polarity protein dishevelled homolog DVL-1;Axin-1;Tuberin;Glycogen synthase kinase-3 beta	DVL1;AXIN1;TSC2;GSK3B	None;AXIN;TSC4;None
7160	GNAS-L-GNB1-GNG4 complex	Human	G-protein alpha(s)-L-beta1-gamma4 complex	None	P50150;P62873;P63092	2786;2782;2778	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNG4;GNB1;GNAS	GNGT4;None;GNAS1 GSP
7161	GNAS-L-GNB2-GNG4 complex	Human	G-protein alpha(s)-L-beta2-gamma4 complex	None	P50150;P62879;P63092	2786;2783;2778	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2;Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNG4;GNB2;GNAS	GNGT4;None;GNAS1 GSP
7162	GNAS-L-GNB3-GNG4 complex	Human	G-protein alpha(s)-L-beta3-gamma4 complex	None	P16520;P50150;P63092	2784;2786;2778	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4;Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNB3;GNG4;GNAS	None;GNGT4;GNAS1 GSP
7163	GNAS-L-GNB4-GNG4 complex	Human	G-protein alpha(s)-L-beta4-gamma4 complex	None	P50150;P63092;Q9HAV0	2786;2778;59345	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4;Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein subunit beta-4	GNG4;GNAS;GNB4	GNGT4;GNAS1 GSP;None
7164	GNAS-L-GNB5-GNG4 complex	Human	G-protein alpha(s)-L-beta5-gamma4 complex	None	O14775;P50150;P63092	10681;2786;2778	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein subunit beta-5;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4;Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNB5;GNG4;GNAS	None;GNGT4;GNAS1 GSP
7165	GNAS-L-GNB1-GNG5 complex	Human	G-protein alpha(s)-L-beta1-gamma5 complex	None	P62873;P63092;P63218	2782;2778;2787	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	GNB1;GNAS;GNG5	None;GNAS1 GSP;GNGT5
7166	GNAS-L-GNB2-GNG5 complex	Human	G-protein alpha(s)-L-beta2-gamma5 complex	None	P62879;P63092;P63218	2783;2778;2787	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2;Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	GNB2;GNAS;GNG5	None;GNAS1 GSP;GNGT5
7167	GNAS-L-GNB3-GNG5 complex	Human	G-protein alpha(s)-L-beta3-gamma5 complex	None	P16520;P63092;P63218	2784;2778;2787	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3;Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	GNB3;GNAS;GNG5	None;GNAS1 GSP;GNGT5
7168	GNAS-L-GNB4-GNG5 complex	Human	G-protein alpha(s)-L-beta4-gamma5 complex	None	P63092;P63218;Q9HAV0	2778;2787;59345	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5;Guanine nucleotide-binding protein subunit beta-4	GNAS;GNG5;GNB4	GNAS1 GSP;GNGT5;None
7169	GNAS-L-GNB5-GNG5 complex	Human	G-protein alpha(s)-L-beta1-gamma5 complex	None	O14775;P63092;P63218	10681;2778;2787	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein subunit beta-5;Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	GNB5;GNAS;GNG5	None;GNAS1 GSP;GNGT5
7170	GNAS-L-GNB1-GNG7 complex	Human	G-protein alpha(s)-L-beta1-gamma7 complex	None	O60262;P62873;P63092	2788;2782;2778	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNG7;GNB1;GNAS	GNGT7;None;GNAS1 GSP
7171	GNAS-L-GNB2-GNG7 complex	Human	G-protein alpha(s)-L-beta2-gamma7 complex	None	O60262;P62879;P63092	2788;2783;2778	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2;Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNG7;GNB2;GNAS	GNGT7;None;GNAS1 GSP
7172	GNAS-L-GNB3-GNG7 complex	Human	G-protein alpha(s)-L-beta3-gamma7 complex	None	O60262;P16520;P63092	2788;2784;2778	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3;Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNG7;GNB3;GNAS	GNGT7;None;GNAS1 GSP
7173	GNAS-L-GNB4-GNG7 complex	Human	G-protein alpha(s)-L-beta4-gamma7 complex	None	O60262;P63092;Q9HAV0	2788;2778;59345	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7;Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein subunit beta-4	GNG7;GNAS;GNB4	GNGT7;GNAS1 GSP;None
7174	GNAS-L-GNB5-GNG7 complex	Human	G-protein alpha(s)-L-beta5-gamma7 complex	None	O14775;O60262;P63092	10681;2788;2778	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein subunit beta-5;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7;Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNB5;GNG7;GNAS	None;GNGT7;GNAS1 GSP
7175	GNAS-L-GNB1-GNG8 complex	Human	G-protein alpha(s)-L-beta1-gamma8 complex	None	P62873;P63092;Q9UK08	2782;2778;94235	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	GNB1;GNAS;GNG8	None;GNAS1 GSP;GNG9 GNGT9
7176	GNAS-L-GNB2-GNG8 complex	Human	G-protein alpha(s)-L-beta2-gamma8 complex	None	P62879;P63092;Q9UK08	2783;2778;94235	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2;Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	GNB2;GNAS;GNG8	None;GNAS1 GSP;GNG9 GNGT9
7177	GNAS-L-GNB3-GNG8 complex	Human	G-protein alpha(s)-L-beta3-gamma8 complex	None	P16520;P63092;Q9UK08	2784;2778;94235	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3;Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	GNB3;GNAS;GNG8	None;GNAS1 GSP;GNG9 GNGT9
7178	GNAS-L-GNB4-GNG8 complex	Human	G-protein alpha(s)-L-beta4-gamma8 complex	None	P63092;Q9HAV0;Q9UK08	2778;59345;94235	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein subunit beta-4;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	GNAS;GNB4;GNG8	GNAS1 GSP;None;GNG9 GNGT9
7179	GNAS-L-GNB5-GNG8 complex	Human	G-protein alpha(s)-L-beta5-gamma8 complex	None	O14775;P63092;Q9UK08	10681;2778;94235	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein subunit beta-5;Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	GNB5;GNAS;GNG8	None;GNAS1 GSP;GNG9 GNGT9
7180	p53-MDM2 complex	Human	None	None	P04637-1;Q00987	7157;4193	MI:0019-coimmunoprecipitation	GO:1904666	regulation of ubiquitin protein ligase activity	None	None	22487680	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Isoform 1 of Cellular tumor antigen p53;E3 ubiquitin-protein ligase Mdm2	TP53;MDM2	P53;None
7181	p53beta-MDM2 complex	Human	None	None	P04637-2;Q00987	7157;4193	MI:0019-coimmunoprecipitation	None	None	None	None	22487680	None	None	P53beta is a splice variant of TP53.	Homo sapiens (Human);Homo sapiens (Human)	Isoform 2 of Cellular tumor antigen p53;E3 ubiquitin-protein ligase Mdm2	TP53;MDM2	P53;None
7182	p53gamma-MDM2 complex	Human	None	None	P04637-3;Q00987	7157;4193	MI:0019-coimmunoprecipitation	None	None	None	None	22487680	None	None	P53gamma is a splice variant of TP53.	Homo sapiens (Human);Homo sapiens (Human)	Isoform 3 of Cellular tumor antigen p53;E3 ubiquitin-protein ligase Mdm2	TP53;MDM2	P53;None
7185	CCNB1-CCNF complex	Human	None	HeLa cells; transfected 293T cells	P14635;P41002	891;899	MI:0019-coimmunoprecipitation;MI:0051-fluorescence technology	GO:0007049	cell cycle	10.03	cell cycle	10716937	A novel interaction between cyclin B1 and cyclin F was identified. Data suggest that the NLS (nuclear localization signal) regions of cyclin F regulate cyclin B1 localization to the nucleus.	None	None	Homo sapiens (Human);Homo sapiens (Human)	G2/mitotic-specific cyclin-B1;Cyclin-F	CCNB1;CCNF	CCNB;FBX1 FBXO1
7186	Glutamate-cysteine ligase	Human	Gamma-glutamylcysteine synthetase; GCLC-GCLM heterodimer	in vitro	P48506;P48507	2729;2730	MI:0071-molecular sieving	GO:0004357	glutamate-cysteine ligase activity	None	None	21657237	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Glutamate--cysteine ligase catalytic subunit;Glutamate--cysteine ligase regulatory subunit	GCLC;GCLM	GLCL GLCLC;GLCLR
7187	GNAS-L-GNB1-GNG10 complex	Human	G-protein alpha(s)-L-beta1-gamma10 complex	None	P50151;P62873;P63092	2790;2782;2778	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNG10;GNB1;GNAS	GNGT10;None;GNAS1 GSP
7188	GNAS-L-GNB2-GNG10 complex	Human	G-protein alpha(s)-L-beta2-gamma10 complex	None	P50151;P62879;P63092	2790;2783;2778	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2;Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNG10;GNB2;GNAS	GNGT10;None;GNAS1 GSP
7189	GNAS-L-GNB3-GNG10 complex	Human	G-protein alpha(s)-L-beta3-gamma10 complex	None	P16520;P50151;P63092	2784;2790;2778	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10;Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNB3;GNG10;GNAS	None;GNGT10;GNAS1 GSP
7190	3-Methylcrotonyl-CoA carboxylase	Human	MCCC; Methylcrotonyl-CoA carboxylase (EC 6.4.1.4)	None	Q96RQ3;Q9HCC0	56922;64087	MI:0004-affinity chromatography technology;MI:0071-molecular sieving	GO:0005739;GO:0004485;GO:0009374	mitochondrion;methylcrotonoyl-CoA carboxylase activity;biotin binding	70.16;16.21.15	mitochondrion;biotin binding	17360195	None	Deficiencies in MCCC activity cause a rare autosomal recessive genetic disorder (17360195).	None	Homo sapiens (Human);Homo sapiens (Human)	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial;Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	MCCC1;MCCC2	MCCA;MCCB
7191	Methionine adenosyltransferase alpha2 beta-v1	Human	MAT2A-MAT2Bv1 complex	in vitro	P31153;Q9NZL9-1	4144;27430	MI:0114-x-ray crystallography	GO:0004478;GO:0048269;GO:0006556	methionine adenosyltransferase activity;methionine adenosyltransferase complex;S-adenosylmethionine biosynthetic process	None	None	25075345	None	None	MAT2Bv1 (9NZL9-1) is a splice variant of MAT2B.	Homo sapiens (Human);Homo sapiens (Human)	S-adenosylmethionine synthase isoform type-2;Isoform 1 of Methionine adenosyltransferase 2 subunit beta	MAT2A;MAT2B	AMS2 MATA2;TGR
7192	CCR4-NOT complex, CNOT7-CNOT6-specific	Human	CCR4-NOT deadenylase CNOT7-CNOT6  complex	HeLa cells	A5YKK6;O75175;Q92600;Q9C0C2;Q9H9A5;Q9NZN8;Q9UIV1;Q9UKZ1;Q9ULM6	23019;4849;9125;85456;25904;4848;29883;55571;57472	MI:0019-coimmunoprecipitation;MI:0227-reverse phase chromatography	GO:0030014;GO:0006355;GO:0043928;GO:0000289;GO:0003723;GO:0000288	CCR4-NOT complex;regulation of DNA-templated transcription;exonucleolytic catabolism of deadenylated mRNA;nuclear-transcribed mRNA poly(A) tail shortening;RNA binding;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	11.02.03.04;16.03.03	transcriptional control;RNA binding	19558367	The core complex consists of 7 subunits (CNOT1, CNOT2, CNOT3, CNOT9, CNOT10, TAB182 and C2ORF29) and is associated with variable deadenylases (CNOT6, CNOT6L, CNOT7 and CNOT8) (PMID: 19558367).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	CCR4-NOT transcription complex subunit 1;CCR4-NOT transcription complex subunit 3;CCR4-NOT transcription complex subunit 9;182 kDa tankyrase-1-binding protein;CCR4-NOT transcription complex subunit 10;CCR4-NOT transcription complex subunit 2;CCR4-NOT transcription complex subunit 7;CCR4-NOT transcription complex subunit 11;CCR4-NOT transcription complex subunit 6	CNOT1;CNOT3;CNOT9;TNKS1BP1;CNOT10;CNOT2;CNOT7;CNOT11;CNOT6	CDC39, KIAA1007, NOT1;KIAA0691 LENG2 NOT3;RCD1 RQCD1;KIAA1741 TAB182;None;CDC36 NOT2;CAF1;C2orf29;CCR4 CCR4a KIAA1194
7193	GNAS-L-GNB4-GNG10 complex	Human	None	None	P50151;P63092;Q9HAV0	2790;2778;59345	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10;Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein subunit beta-4	GNG10;GNAS;GNB4	GNGT10;GNAS1 GSP;None
7194	GNAS-L-GNB5-GNG10 complex	Human	G-protein alpha(s)-L-beta5-gamma10 complex	None	O14775;P50151;P63092	10681;2790;2778	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein subunit beta-5;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10;Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNB5;GNG10;GNAS	None;GNGT10;GNAS1 GSP
7195	GNAS-L-GNB1-GNG11 complex	Human	G-protein alpha(s)-L-beta1-gamma11 complex	None	P61952;P62873;P63092	2791;2782;2778	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNG11;GNB1;GNAS	GNGT11;None;GNAS1 GSP
7196	Methionine adenosyltransferase alpha2 beta-v2	Human	MAT2A-MAT2Bv2 complex	in vitro	P31153;Q9NZL9-2	4144;27430	MI:0071-molecular sieving;MI:0114-x-ray crystallography	GO:0004478;GO:0048269;GO:0006556	methionine adenosyltransferase activity;methionine adenosyltransferase complex;S-adenosylmethionine biosynthetic process	None	None	25075345	None	None	MAT2Bv2(9NZL9-2) is a splice variant of MAT2B.	Homo sapiens (Human);Homo sapiens (Human)	S-adenosylmethionine synthase isoform type-2;Isoform 2 of Methionine adenosyltransferase 2 subunit beta	MAT2A;MAT2B	AMS2 MATA2;TGR
7197	Methionine adenosyltransferase alpha1 beta-v1	Human	MAT1A-MAT2Bv1 complex	in vitro	Q00266;Q9NZL9	4143;27430	MI:0071-molecular sieving;MI:0114-x-ray crystallography	GO:0004478;GO:0048269;GO:0006556	methionine adenosyltransferase activity;methionine adenosyltransferase complex;S-adenosylmethionine biosynthetic process	None	None	25075345	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	S-adenosylmethionine synthase isoform type-1;Methionine adenosyltransferase 2 subunit beta	MAT1A;MAT2B	AMS1,MATA1;TGR
7199	GNAS-L-GNB2-GNG11 complex	Human	G-protein alpha(s)-L-beta2-gamma11 complex	None	P61952;P62879;P63092	2791;2783;2778	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2;Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNG11;GNB2;GNAS	GNGT11;None;GNAS1 GSP
7201	GNAS-L-GNB3-GNG11 complex	Human	G-protein alpha(s)-L-beta3-gamma11 comple	None	P16520;P61952;P63092	2784;2791;2778	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11;Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNB3;GNG11;GNAS	None;GNGT11;GNAS1 GSP
7202	GNAS-L-GNB4-GNG11 complex	Human	G-protein alpha(s)-L-beta4-gamma11 complex	None	P61952;P63092;Q9HAV0	2791;2778;59345	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11;Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein subunit beta-4	GNG11;GNAS;GNB4	GNGT11;GNAS1 GSP;None
7203	GNAS-L-GNB5-GNG11 complex	Human	G-protein alpha(s)-L-beta5-gamma11 complex	None	O14775;P61952;P63092	10681;2791;2778	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein subunit beta-5;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11;Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNB5;GNG11;GNAS	None;GNGT11;GNAS1 GSP
7204	GNAS-L-GNB1-GNG12 complex	Human	G-protein alpha(s)-L-beta1-gamma12 complex	None	P62873;P63092;Q9UBI6	2782;2778;55970	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	GNB1;GNAS;GNG12	None;GNAS1 GSP;None
7205	GNAS-L-GNB2-GNG12 complex	Human	G-protein alpha(s)-L-beta2-gamma12 complex	None	P62879;P63092;Q9UBI6	2783;2778;55970	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2;Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	GNB2;GNAS;GNG12	None;GNAS1 GSP;None
7206	GNAS-L-GNB3-GNG12 complex	Human	G-protein alpha(s)-L-beta3-gamma12 complex	None	P16520;P63092;Q9UBI6	2784;2778;55970	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3;Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	GNB3;GNAS;GNG12	None;GNAS1 GSP;None
7207	GNAS-L-GNB4-GNG12 complex	Human	G-protein alpha(s)-L-beta4-gamma12 complex	None	P63092;Q9HAV0;Q9UBI6	2778;59345;55970	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein subunit beta-4;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	GNAS;GNB4;GNG12	GNAS1 GSP;None;None
7208	GNAS-L-GNB5-GNG12 complex	Human	G-protein alpha(s)-L-beta5-gamma12 complex	None	O14775;P63092;Q9UBI6	10681;2778;55970	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein subunit beta-5;Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	GNB5;GNAS;GNG12	None;GNAS1 GSP;None
7209	GNAS-L-GNB1-GNG13 complex	Human	G-protein alpha(s)-L-beta1-gamma13 complex	None	P62873;P63092;Q9P2W3	2782;2778;51764	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13	GNB1;GNAS;GNG13	None;GNAS1 GSP;None
7210	GNAS-L-GNB2-GNG13 complex	Human	G-protein alpha(s)-L-beta2-gamma13 complex	None	P62879;P63092;Q9P2W3	2783;2778;51764	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2;Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13	GNB2;GNAS;GNG13	None;GNAS1 GSP;None
7211	GNAS-L-GNB3-GNG13 complex	Human	G-protein alpha(s)-L-beta3-gamma13 complex	None	P16520;P63092;Q9P2W3	2784;2778;51764	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3;Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13	GNB3;GNAS;GNG13	None;GNAS1 GSP;None
7212	GNAS-L-GNB4-GNG13 complex	Human	G-protein alpha(s)-L-beta4-gamma13 complex	None	P63092;Q9HAV0;Q9P2W3	2778;59345;51764	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein subunit beta-4;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13	GNAS;GNB4;GNG13	GNAS1 GSP;None;None
7213	GNAS-L-GNB5-GNG13 complex	Human	G-protein alpha(s)-L-beta5-gamma13 complex	None	O14775;P63092;Q9P2W3	10681;2778;51764	MI:0019-coimmunoprecipitation	None	None	None	None	25733868	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein subunit beta-5;Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13	GNB5;GNAS;GNG13	None;GNAS1 GSP;None
7214	CCR4-NOT complex, CNOT7-CNOT6L-specific	Human	CCR4-NOT deadenylase CNOT7-CNOT6L  complex	HeLa cells	A5YKK6;O75175;Q92600;Q96LI5;Q9C0C2;Q9H9A5;Q9NZN8;Q9UIV1;Q9UKZ1	23019;4849;9125;246175;85456;25904;4848;29883;55571	MI:0019-coimmunoprecipitation;MI:0227-reverse phase chromatography	GO:0030014;GO:0006355;GO:0000288;GO:0000289;GO:0043928;GO:0003723;GO:0019079	CCR4-NOT complex;regulation of DNA-templated transcription;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;nuclear-transcribed mRNA poly(A) tail shortening;exonucleolytic catabolism of deadenylated mRNA;RNA binding;viral genome replication	11.02.03.04;16.03.03	transcriptional control;RNA binding	19558367	The core complex consists of 7 subunits (CNOT1, CNOT2, CNOT3, CNOT9, CNOT10, TAB182 and C2ORF29) and is associated with variable deadenylases (CNOT6, CNOT6L, CNOT7 and CNOT8) (PMID:19558367). Four of the nine subunits of the CCR4-NOT complex (CNOT1, CNOT2, CNOT3, and CNOT6L) are required for Hepatitis C virus infection (PMID:19717417). Bioinformatic analyses confirmed that influenza A virus strain H1N1 significantly regulates the RNA degradation pathway via up-regulation of CCR4-NOT transcription complex subunit 4 (PMID:31271652).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	CCR4-NOT transcription complex subunit 1;CCR4-NOT transcription complex subunit 3;CCR4-NOT transcription complex subunit 9;CCR4-NOT transcription complex subunit 6-like;182 kDa tankyrase-1-binding protein;CCR4-NOT transcription complex subunit 10;CCR4-NOT transcription complex subunit 2;CCR4-NOT transcription complex subunit 7;CCR4-NOT transcription complex subunit 11	CNOT1;CNOT3;CNOT9;CNOT6L;TNKS1BP1;CNOT10;CNOT2;CNOT7;CNOT11	CDC39, KIAA1007, NOT1;KIAA0691 LENG2 NOT3;RCD1 RQCD1;CCR4B;KIAA1741 TAB182;None;CDC36 NOT2;CAF1;C2orf29
7215	CCR4-NOT complex, CNOT8-CNOT6-specific	Human	CCR4-NOT deadenylase CNOT8-CNOT6  complex	HeLa cells	A5YKK6;O75175;Q92600;Q9C0C2;Q9H9A5;Q9NZN8;Q9UFF9;Q9UKZ1;Q9ULM6	23019;4849;9125;85456;25904;4848;9337;55571;57472	MI:0019-coimmunoprecipitation;MI:0227-reverse phase chromatography	GO:0030014;GO:0006355;GO:0043928;GO:0000288;GO:0000289;GO:0003723	CCR4-NOT complex;regulation of DNA-templated transcription;exonucleolytic catabolism of deadenylated mRNA;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;nuclear-transcribed mRNA poly(A) tail shortening;RNA binding	11.02.03.04;16.03.03	transcriptional control;RNA binding	19558367	The core complex consists of 7 subunits (CNOT1, CNOT2, CNOT3, CNOT9, CNOT10, TAB182 and C2ORF29) and is associated with variable deadenylases (CNOT6, CNOT6L, CNOT7 and CNOT8) (19558367).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	CCR4-NOT transcription complex subunit 1;CCR4-NOT transcription complex subunit 3;CCR4-NOT transcription complex subunit 9;182 kDa tankyrase-1-binding protein;CCR4-NOT transcription complex subunit 10;CCR4-NOT transcription complex subunit 2;CCR4-NOT transcription complex subunit 8;CCR4-NOT transcription complex subunit 11;CCR4-NOT transcription complex subunit 6	CNOT1;CNOT3;CNOT9;TNKS1BP1;CNOT10;CNOT2;CNOT8;CNOT11;CNOT6	CDC39, KIAA1007, NOT1;KIAA0691 LENG2 NOT3;RCD1 RQCD1;KIAA1741 TAB182;None;CDC36 NOT2;CALIF POP2;C2orf29;CCR4 CCR4a KIAA1194
7216	CCR4-NOT complex, CNOT8-CNOT6L-specific	Human	CCR4-NOT deadenylase CNOT8-CNOT6L  complex	HeLa cells	A5YKK6;O75175;Q92600;Q96LI5;Q9C0C2;Q9H9A5;Q9NZN8;Q9UFF9;Q9UKZ1	23019;4849;9125;246175;85456;25904;4848;9337;55571	MI:0019-coimmunoprecipitation;MI:0227-reverse phase chromatography	GO:0030014;GO:0006355;GO:0000288;GO:0000289;GO:0043928;GO:0003723;GO:0019079	CCR4-NOT complex;regulation of DNA-templated transcription;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;nuclear-transcribed mRNA poly(A) tail shortening;exonucleolytic catabolism of deadenylated mRNA;RNA binding;viral genome replication	11.02.03.04;16.03.03	transcriptional control;RNA binding	19558367	The core complex consists of 7 subunits (CNOT1, CNOT2, CNOT3, CNOT9, CNOT10, TAB182 and C2ORF29) and is associated with variable deadenylases (CNOT6, CNOT6L, CNOT7 and CNOT8) (PMID:19558367). Four of the nine subunits of the CCR4-NOT complex (CNOT1, CNOT2, CNOT3, and CNOT6L) are required for Hepatitis C virus infection (PMID:19717417). Bioinformatic analyses confirmed that influenza A virus strains H1N1 significantly regulates the RNA degradation pathway via up-regulation of CCR4-NOT transcription complex subunit 4 (PMID:31271652).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	CCR4-NOT transcription complex subunit 1;CCR4-NOT transcription complex subunit 3;CCR4-NOT transcription complex subunit 9;CCR4-NOT transcription complex subunit 6-like;182 kDa tankyrase-1-binding protein;CCR4-NOT transcription complex subunit 10;CCR4-NOT transcription complex subunit 2;CCR4-NOT transcription complex subunit 8;CCR4-NOT transcription complex subunit 11	CNOT1;CNOT3;CNOT9;CNOT6L;TNKS1BP1;CNOT10;CNOT2;CNOT8;CNOT11	CDC39, KIAA1007, NOT1;KIAA0691 LENG2 NOT3;RCD1 RQCD1;CCR4B;KIAA1741 TAB182;None;CDC36 NOT2;CALIF POP2;C2orf29
7218	DTNBP1(splice variant 1B)-PRKDC-XRCC5-XRCC6 complex	Human	None	COS cells	P12956;P13010;P78527;Q96EV8-3	2547;7520;5591;84062	MI:0019-coimmunoprecipitation	GO:0006355	regulation of DNA-templated transcription	11.02.03.04	transcriptional control	19142223	The DNA-dependent protein kinase (DNA-PK) complex interacts only with dysbindin-1 splice isoforms A (Q96EV8-1) and B (Q96EV8-3), but not with C. isoforms A and B localized in nucleus, where the kinase complex exist, whereas the isoform C was found exclusively in cytosol. Furthermore, results of phosphorylation assay suggest that the DNA-PK complex phosphorylated dysbindin-1 isoforms A and B in cells. These observations suggest that DNA-PK regulates the dysbindin-1 isoforms A and B by phosphorylation in nucleus. Isoform C does not contain exons from 1 to 6.	None	Dysbindin 1B is a splice variant of DTNBP1 (Q96EV8-3).	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	X-ray repair cross-complementing protein 6;X-ray repair cross-complementing protein 5;DNA-dependent protein kinase catalytic subunit;Isoform 3 of Dysbindin	XRCC6;XRCC5;PRKDC;DTNBP1	G22P1;G22P2;HYRC HYRC1;BLOC1S8
7219	DHHC6-SELK complex	Human	DHHC6-SELENOK complex	HEK293 cells	Q9H6R6;Q9Y6D0	64429;58515	MI:0007-anti tag coimmunoprecipitation	GO:0005783;GO:0006955;GO:0018345	endoplasmic reticulum;immune response;protein palmitoylation	70.07;36.25.16	endoplasmic reticulum;immune response	25368151	DHHC6 and SELK interact through SH3 domain and SH3-binding domains, respectively, to form a complex in the ER membrane. DHHC6-SELK complex catalyzes the posttranslational palmitoylation of the IP3R Ca2+ channel to regulate immune cell activation. (PMID:25368151).	None	None	Homo sapiens (Human);Homo sapiens (Human)	Palmitoyltransferase ZDHHC6;Selenoprotein K	ZDHHC6;SELENOK	ZNF376;SELK
7220	MSL complex	Human	MOF-MSL1-MSL2-MSL3L1 complex	HEK293FRT or Hela cells	Q68DK7;Q8N5Y2;Q9H7Z6;Q9HCI7	339287;10943;84148;55167	MI:0004-affinity chromatography technology	GO:0043984;GO:0043981	histone H4-K16 acetylation;histone H4-K5 acetylation	None	None	20018852	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Male-specific lethal 1 homolog;Male-specific lethal 3 homolog;Histone acetyltransferase KAT8;E3 ubiquitin-protein ligase MSL2	MSL1;MSL3;KAT8;MSL2	MSL1L1;MSL3L1;MOF MYST1;KIAA1585 MSL2L1 RNF184
7221	NSL complex	Human	None	HEK293FRT or Hela cells	O15294;P51610;P61964;Q7Z3B3;Q96EZ8;Q9BVI0;Q9H7Z6;Q9H9L4;Q9P2N6	8473;3054;11091;284058;10445;51230;84148;54934;55683	MI:0004-affinity chromatography technology	GO:0043984;GO:0043981	histone H4-K16 acetylation;histone H4-K5 acetylation	None	None	20018852	MSL-associated MOF acetylates nucleosomal histone H4 almost exclusively on lysine 16, NSL-associated MOF exhibits a relaxed specificity and also acetylates nucleosomal histone H4 on lysines 5 and 8 (PMID:20018852).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit;Host cell factor 1;WD repeat-containing protein 5;KAT8 regulatory NSL complex subunit 1;Microspherule protein 1;PHD finger protein 20;Histone acetyltransferase KAT8;KAT8 regulatory NSL complex subunit 2;KAT8 regulatory NSL complex subunit 3	OGT;HCFC1;WDR5;KANSL1;MCRS1;PHF20;KAT8;KANSL2;KANSL3	None;HCF1, HFC1;BIG3;CENP-36 KIAA1267 MSL1V1 NSL1;INO80Q MSP58;C20orf104 GLEA2 HCA58 NZF TZP;MOF MYST1;C12orf41,NSL2;KIAA1310 NSL3 PRTD SI1
7222	MMS19-XPD complex	Human	MMS19-ERCC2 complex	HeLa cells; HEK293T cells	P18074;Q96T76	2068;64210	MI:0019-coimmunoprecipitation	GO:0016226;GO:0004386	iron-sulfur cluster assembly;helicase activity	None	None	28178521	The Fe-S helicase XPD interacts independently and directlywith MMS19. Co-IP experiments with Flag-MMS19 and XPD showed a robust interaction between MMS19 and XPD that was independent of the co-expression of MIP18 and/orCIAO1.	Mutations in the XPD gene result in xeroderma pigmentosum (XP) and trichothiodystrophy (TTD), the phenotypes of which are often intricate (PMID:12820975).	None	Homo sapiens (Human);Homo sapiens (Human)	General transcription and DNA repair factor IIH helicase subunit XPD;MMS19 nucleotide excision repair protein homolog	ERCC2;MMS19	XPD XPDC;MMS19L
7223	MMS19-FAM96B complex	Human	MMS19-MIP18 complex	HeLa cells; HEK293T cells	Q96T76;Q9Y3D0	64210;51647	MI:0019-coimmunoprecipitation	GO:0030163	protein catabolic process	14.13	protein/peptide degradation	28178521	MMS19 binds to MIP18 and protects it from proteasomaldegradation.	None	None	Homo sapiens (Human);Homo sapiens (Human)	MMS19 nucleotide excision repair protein homolog;Cytosolic iron-sulfur assembly component 2B	MMS19;CIAO2B	MMS19L;CIAB FAM96B MIP18
7224	HCF1-THAP11 complex	Human	THAP11-HCF1 complex	nuclear extracts from SW620 cells	P51610;Q96EK4	3054;57215	MI:0019-coimmunoprecipitation	GO:0001558;GO:0005634;GO:0003677	regulation of cell growth;nucleus;DNA binding	70.10;16.03.01	nucleus;DNA binding	22371484	THAP11 is highly expressed in human colon cancers, both primary tumors and metastases (PMID:22371484).	None	None	Homo sapiens (Human);Homo sapiens (Human)	Host cell factor 1;THAP domain-containing protein 11	HCFC1;THAP11	HCF1, HFC1;None
7225	CDH4-HDAC2-MTA2-RBBP7-TWIST1 complex	Human	TWIST-MTA2-RbAp46-Mi2-HDAC2 complex	HEK293 cells	O94776;Q14839;Q15672;Q16576;Q92769	9219;1108;7291;5931;3066	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0051090;GO:0030334	regulation of DNA-binding transcription factor activity;regulation of cell migration	18.02.09	regulator of transcription factor	20714342	None	The components of TWIST complex are required for cancer metastasis in vivo (PMID:20714342).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Metastasis-associated protein MTA2;Chromodomain-helicase-DNA-binding protein 4;Twist-related protein 1;Histone-binding protein RBBP7;Histone deacetylase 2	MTA2;CHD4;TWIST1;RBBP7;HDAC2	MTA1L1 PID;None;BHLHA38 TWIST;RBAP46;None
7233	DLC1-DLGAP1-MYO5A complex	Human	GKAP-DLC-myosin-V complex	None	O14490;Q96QB1;Q9Y4I1	9229;10395;4644	MI:0096-pull down	None	None	None	None	10844022	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Disks large-associated protein 1;Rho GTPase-activating protein 7;Unconventional myosin-Va	DLGAP1;DLC1;MYO5A	DAP1 GKAP;ARHGAP7,KIAA1723,STARD12;MYH12
7234	DLGAP1-DLG4-DYNLL2 complex	Human	GKAP-PSD-95-DLC2 complex	None	O14490;P78352;Q96FJ2	9229;1742;140735	MI:0096-pull down	None	None	None	None	10844022	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Disks large-associated protein 1;Disks large homolog 4;Dynein light chain 2, cytoplasmic	DLGAP1;DLG4;DYNLL2	DAP1 GKAP;PSD95;DLC2
7235	DISC1-DRD2 complex	Human	None	Striatal neurons	P14416;Q9NRI5	1813;27185	MI:0019-coimmunoprecipitation	None	None	None	None	25433637	DRD2 forms a protein complex with Disrupted in Schizophrenia1 (DISC1) that facilitates D2R-mediatedglycogen synthase kinase (GSK)-3 signaling and inhibits agonist-induced D2R internalization (PMID:25433637).	None	None	Homo sapiens (Human);Homo sapiens (Human)	D(2) dopamine receptor;Disrupted in schizophrenia 1 protein	DRD2;DISC1	None;KIAA0457
7236	ATXN1-CIC complex	Human	Ataxin-1-Capicua complex	None	P54253;Q96RK0	6310;23152	MI:0114-x-ray crystallography	None	None	None	None	23512657	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Ataxin-1;Protein capicua homolog	ATXN1;CIC	ATX1,SCA1;KIAA0306
7239	CHRNA7-NMDAR1 complex	Human	alpha7-nAChR-GluN1 complex	brain	P36544;Q05586	1139;2902	MI:0096-pull down	None	None	None	None	29261717	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Neuronal acetylcholine receptor subunit alpha-7;Glutamate receptor ionotropic, NMDA 1	CHRNA7;GRIN1	NACHRA7;NMDAR1
7240	CHRNA7-GRIN2A complex	Human	None	brain	P36544;Q12879	1139;2903	MI:0004-affinity chromatography technology	None	None	None	None	29261717	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Neuronal acetylcholine receptor subunit alpha-7;Glutamate receptor ionotropic, NMDA 2A	CHRNA7;GRIN2A	NACHRA7;NMDAR2A
7241	SNCA-TUBB3 complex	Human	beta-III Tubulin-beta-synuclein complex	Neurons	P37840;Q13509	6622;10381	MI:0051-fluorescence technology;MI:0096-pull down	None	None	None	None	25028513	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Alpha-synuclein;Tubulin beta-3 chain	SNCA;TUBB3	NACP PARK1;TUBB4
7242	RPGRIP1-SPATA7 complex	Human	None	retina cells	Q96KN7;Q9P0W8	57096;55812	MI:0018-two hybrid	GO:0051223;GO:1903621;GO:0032391;GO:0097730;GO:1903546;GO:0007601	regulation of protein transport;protein localization to photoreceptor connecting cilium;photoreceptor connecting cilium;non-motile cilium;protein localization to photoreceptor outer segment;visual perception	34.11.01.03	visual transduction	25398945	None	Mutations in SPATA7 and RPGRIP1 cause Leber congenital amaurosis.	None	Homo sapiens (Human);Homo sapiens (Human)	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1;Spermatogenesis-associated protein 7	RPGRIP1;SPATA7	None;HSD3
7243	AURKA-HRAS-RAF1 complex	Human	None	None	O14965;P01112;P04049	6790;3265;5894	MI:0096-pull down	GO:0043405	regulation of MAP kinase activity	None	None	28177880	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Aurora kinase A;GTPase HRas;RAF proto-oncogene serine/threonine-protein kinase	AURKA;HRAS;RAF1	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6;HRAS1;RAF
7246	P53alpha-P53beta complex	Human	p53alpha-p53beta complex	MCF cells	P04637-1;P04637-2	7157;7157	MI:0019-coimmunoprecipitation	None	None	None	None	24926616	p53beta and p53gamma modulate p53alpha transcriptional activity through, at least in part, the formation of DNA-mediated p53alpha/p53beta and p53alpha/p53gamma protein complex (PMID:24926616).	None	P53alpha and P53beta are splice variants of TP53.	Homo sapiens (Human);Homo sapiens (Human)	Isoform 1 of Cellular tumor antigen p53;Isoform 2 of Cellular tumor antigen p53	TP53;TP53	P53;P53
7247	P53alpha-P53gamma complex	Human	None	MCF cells	P04637-1;P04637-3	7157;7157	MI:0019-coimmunoprecipitation	None	None	None	None	24926616	p53beta and p53gamma modulate p53alpha transcriptional activity through, at least in part, the formation of DNA-mediated p53alpha/p53beta and p53alpha/p53gamma protein complex (PMID:24926616).	None	P53alpha and P53gamma are splice variants of TP53.	Homo sapiens (Human);Homo sapiens (Human)	Isoform 1 of Cellular tumor antigen p53;Isoform 3 of Cellular tumor antigen p53	TP53;TP53	P53;P53
7248	ABCB1-ANXA2-RACK1-SRC complex	Human	Rack1-P-gp-Src-Anxa2 complex	HEK-293T cells	P07355;P08183;P12931;P63244	302;5243;6714;10399	MI:0019-coimmunoprecipitation	None	None	None	None	27754360	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Annexin A2;ATP-dependent translocase ABCB1;Proto-oncogene tyrosine-protein kinase Src;Receptor of activated protein C kinase 1	ANXA2;ABCB1;SRC;RACK1	ANX2 ANX2L4 CAL1H LPC2D;MDR1 PGY1;SRC1;GNB2L1
7249	ERS1-MDM2 complex	Human	None	ZR-75-1 cells	P03372;Q00987	2099;4193	MI:0019-coimmunoprecipitation	None	None	None	None	26909605	None	OMIM:114480 Breast cancer (PMID: 26909605).	None	Homo sapiens (Human);Homo sapiens (Human)	Estrogen receptor;E3 ubiquitin-protein ligase Mdm2	ESR1;MDM2	ESR NR3A1;None
7250	ESR1-MDM4 complex	Human	None	ZR-75-1 cells; patient's breast tumour cells	O15151;P03372	4194;2099	MI:0019-coimmunoprecipitation	None	None	None	None	26909605	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Protein Mdm4;Estrogen receptor	MDM4;ESR1	MDMX;ESR NR3A1
7251	IGBP1-MID1-PPP2CA complex	Human	MID1 regulator complex	None	O15344;P67775;P78318	4281;5515;3476	MI:0019-coimmunoprecipitation	GO:0016049;GO:2000224	cell growth;regulation of testosterone biosynthetic process	40.01	cell growth / morphogenesis	24484909	Disruption of the MID1-alpha4/PP2A protein complex inhibits prostate cancer cell growth and decreases AR protein levels. (PMID:24484909).	OMIM:176807 prostate cancer	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase Midline-1;Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform;Immunoglobulin-binding protein 1	MID1;PPP2CA;IGBP1	FXY RNF59 TRIM18 XPRF;None;IBP1
7252	ING5 (BRPF2, MOZ, MORF) complex	Human	ING5 (BRPF2, KAT6A, KAT6B) complex	HeLa S3 cells	O95696;Q8WYB5;Q8WYH8;Q92794;Q9HAF1	23774;23522;84289;7994;64769	MI:0069-mass spectrometry studies of complexes	GO:0006915;GO:0000278;GO:0051726	apoptotic process;mitotic cell cycle;regulation of cell cycle	40.10.02;10.03.01.01;10.03.01	apoptosis (type I programmed cell death);mitotic cell cycle;mitotic cell cycle and cell cycle control	16387653	ING5 HAT complexes interact with the MCM helicase and are essential for DNA replication to occur during S phase.ING subunits are probably crucial for acetylation of chromatin substrates. ING5 fractionates with two distinct complexes containing HBO1 or nucleosomal H3-specific MOZ/MORF HATs. Both MOZ/MORF-ING5 and HBO1-ING5 HAT complexes are important for DNA replication.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Bromodomain-containing protein 1;Histone acetyltransferase KAT6B;Inhibitor of growth protein 5;Histone acetyltransferase KAT6A;Chromatin modification-related protein MEAF6	BRD1;KAT6B;ING5;KAT6A;MEAF6	BRL,BRPF2;KIAA0383 MORF MOZ2 MYST4;None;MOZ MYST3 RUNXBP2 ZNF220;C1orf149 CENP-28 EAF6
7253	ING5 (BRPF3, MOZ, MORF) complex	Human	ING5 (BRPF3, KAT6A, KAT6B) complex	HeLa S3 cells	Q8WYB5;Q8WYH8;Q92794;Q9HAF1;Q9ULD4	23522;84289;7994;64769;27154	MI:0069-mass spectrometry studies of complexes	GO:0006915;GO:0000278;GO:0051726	apoptotic process;mitotic cell cycle;regulation of cell cycle	40.10.02;10.03.01.01;10.03.01	apoptosis (type I programmed cell death);mitotic cell cycle;mitotic cell cycle and cell cycle control	16387653	ING5 HAT complexes interact with the MCM helicase and are essential for DNA replication to occur during S phase.ING subunits are probably crucial for acetylation of chromatin substrates. ING5 fractionates with two distinct complexes containing HBO1 or nucleosomal H3-specific MOZ/MORF HATs. Both MOZ/MORF-ING5 and HBO1-ING5 HAT complexes are important for DNA replication.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone acetyltransferase KAT6B;Inhibitor of growth protein 5;Histone acetyltransferase KAT6A;Chromatin modification-related protein MEAF6;Bromodomain and PHD finger-containing protein 3	KAT6B;ING5;KAT6A;MEAF6;BRPF3	KIAA0383 MORF MOZ2 MYST4;None;MOZ MYST3 RUNXBP2 ZNF220;C1orf149 CENP-28 EAF6;KIAA1286
7254	ING5 complex (ING5, JADE2, KAT7, MEAF6)	Human	ING5 complex (ING5, PHF15, HBO1, C1orf149)	HeLa S3 cells	O95251;Q8WYH8;Q9HAF1;Q9NQC1	11143;84289;64769;23338	MI:0069-mass spectrometry studies of complexes	GO:0006915;GO:0000278;GO:0051726	apoptotic process;mitotic cell cycle;regulation of cell cycle	40.10.02;10.03.01.01;10.03.01	apoptosis (type I programmed cell death);mitotic cell cycle;mitotic cell cycle and cell cycle control	16387653	Members of the ING family of tumor suppressors regulatecell cycle progression, apoptosis, and DNA repair. HBO1-ING5 association is independent of MOZ/MORF and is responsible for the H4-specific HAT activity in purified ING5.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone acetyltransferase KAT7;Inhibitor of growth protein 5;Chromatin modification-related protein MEAF6;E3 ubiquitin-protein ligase Jade-2	KAT7;ING5;MEAF6;JADE2	HBO1 HBOa MYST2;None;C1orf149 CENP-28 EAF6;KIAA0239 PHF15
7255	ING5 complex (ING5, JADE3, KAT7, MEAF6)	Human	ING5 complex (ING5, PHF16, HBO1, C1orf149)	HeLa S3 cells	O95251;Q8WYH8;Q92613;Q9HAF1	11143;84289;9767;64769	MI:0069-mass spectrometry studies of complexes	GO:0006915;GO:0000278;GO:0051726	apoptotic process;mitotic cell cycle;regulation of cell cycle	40.10.02;10.03.01.01;10.03.01	apoptosis (type I programmed cell death);mitotic cell cycle;mitotic cell cycle and cell cycle control	16387653	Members of the ING family of tumor suppressors regulatecell cycle progression, apoptosis, and DNA repair. HBO1-ING5 association is independent of MOZ/MORF and is responsible for the H4-specific HAT activity in purified ING5.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone acetyltransferase KAT7;Inhibitor of growth protein 5;Protein Jade-3;Chromatin modification-related protein MEAF6	KAT7;ING5;JADE3;MEAF6	HBO1 HBOa MYST2;None;KIAA0215, PHF16;C1orf149 CENP-28 EAF6
7256	ABCB1-PPP2R3C-TFPI2 complex	Human	None	HEK293 cells	P08183;P48307;Q969Q6	5243;7980;55012	MI:0019-coimmunoprecipitation	GO:0001932	regulation of protein phosphorylation	None	None	24333728	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	ATP-dependent translocase ABCB1;Tissue factor pathway inhibitor 2;Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma	ABCB1;TFPI2;PPP2R3C	MDR1 PGY1;None;C14orf10 G5PR
7259	HCFC1-THAP11-ZNF143 complex	Human	THAP11-ZNF143-HCFC1 complex	SW620 colon cancer cell line	P51610;P52747;Q96EK4	3054;7702;57215	MI:0402-chromatin immunoprecipitation assay	GO:0006355;GO:0003677	regulation of DNA-templated transcription;DNA binding	11.02.03.04;16.03.01	transcriptional control;DNA binding	26416877	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Host cell factor 1;Zinc finger protein 143;THAP domain-containing protein 11	HCFC1;ZNF143;THAP11	HCF1, HFC1;SBF STAF;None
7262	3-Hydroxyacyl CoA dehydrogenase	Human	Trifunctional enzyme	liver	P40939;P55084	3030;3032	MI:0071-molecular sieving	GO:0006635;GO:0005739	fatty acid beta-oxidation;mitochondrion	70.16	mitochondrion	8163672	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Trifunctional enzyme subunit alpha, mitochondrial;Trifunctional enzyme subunit beta, mitochondrial	HADHA;HADHB	HADH;None
7263	ABCG5-ABCG8 sterol transporter	Human	ABCG5-ABCG8 complex	in vitro	Q9H221;Q9H222	64241;64240	MI:0071-molecular sieving	GO:0015918;GO:0005524	sterol transport;ATP binding	16.19.03	ATP binding	20210363	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	ATP-binding cassette sub-family G member 8;ATP-binding cassette sub-family G member 5	ABCG8;ABCG5	None;None
7265	MLC1-Na,K-ATPase-Kir4.1-AQP4-TRPV4-syntrophin complex	Human	AQP4-ATP1B1-KCNJ10-MLC1-SNTG1-TRPV4	astrocytoma cell line U251	P05026;P55087;P78508;Q15049;Q9HBA0;Q9NSN8	481;361;3766;None;59341;54212	MI:0004-affinity chromatography technology	GO:0009992;GO:0005886	cellular water homeostasis;plasma membrane	70.02	eukaryotic plasma membrane / membrane attached	22328087	None	Mutations in MCL1 are the causative factor for megalencephalic leukoencephalopathy with subcortical cysts. Mutations in MCL1 impair the functional interaction of MCL1 with the macromolecular protein complex that includes Na,K-ATPase, Kir4.1, AQP-4, TRPV4 and syntrophin.	Since the authors did not specify sntrophin, we used isoform SNTG1.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Sodium/potassium-transporting ATPase subunit beta-1;Aquaporin-4;ATP-sensitive inward rectifier potassium channel 10;Membrane protein MLC1;Transient receptor potential cation channel subfamily V member 4;Gamma-1-syntrophin	ATP1B1;AQP4;KCNJ10;MLC1;TRPV4;SNTG1	ATP1B;None;None;KIAA0027 WKL1;VRL2, VROAC;None
7266	AKT1-NQO2 complex	Human	None	CWR22Rv1	P16083;P31749	4835;207	MI:0071-molecular sieving	GO:0006954;GO:0008283;GO:0043491	inflammatory response;cell population proliferation;protein kinase B signaling	36.25.16.07	inflammatory response	24968355	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Ribosyldihydronicotinamide dehydrogenase [quinone];RAC-alpha serine/threonine-protein kinase	NQO2;AKT1	NMOR2;PKB RAC
7267	KAT2A-Oxoglutarate dehydrogenase complex	Human	KAT2A-alpha-Ketoglutarate dehydrogenase complex	U251 cells	P09622;P36957;Q02218;Q92830	1738;1743;4967;2648	MI:0019-coimmunoprecipitation	GO:0005634	nucleus	70.10	nucleus	29211711	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Dihydrolipoyl dehydrogenase, mitochondrial;Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial;2-oxoglutarate dehydrogenase complex component E1;Histone acetyltransferase KAT2A	DLD;DLST;OGDH;KAT2A	GCSL LAD PHE3;DLTS;None;GCN5 GCN5L2
7268	HEPACAM-MLC1-Na,K-ATPase-Kir4.1-AQP4-TRPV4 complex	Human	AQP4-ATP1B1-HEPACAM-KCNJ10-MLC1-TRPV4 complex	astrocytoma cell line U251	P05026;P55087;P78508;Q14CZ8;Q15049;Q9HBA0	481;361;3766;220296;None;59341	MI:0004-affinity chromatography technology	GO:0005886;GO:0009992	plasma membrane;cellular water homeostasis	70.02	eukaryotic plasma membrane / membrane attached	22328087	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Sodium/potassium-transporting ATPase subunit beta-1;Aquaporin-4;ATP-sensitive inward rectifier potassium channel 10;Hepatocyte cell adhesion molecule;Membrane protein MLC1;Transient receptor potential cation channel subfamily V member 4	ATP1B1;AQP4;KCNJ10;HEPACAM;MLC1;TRPV4	ATP1B;None;None;None;KIAA0027 WKL1;VRL2, VROAC
7269	p532-Clathrin-HSP70 complex	Human	HERC1-CLTC-HSPA1A complex	MCF-7 cells	P0DMV8;Q00610;Q15751	3303;1213;8925	MI:0019-coimmunoprecipitation	GO:0055085;GO:0005737	transmembrane transport;cytoplasm	70.03	cytoplasm	9233772	Cytosolic  p532 (HERC1) is complexed with clathrin and  HSP70  whereas membrane-associated p532 co-localizes with ARF1.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Heat shock 70 kDa protein 1A;Clathrin heavy chain 1;Probable E3 ubiquitin-protein ligase HERC1	HSPA1A;CLTC;HERC1	HSP72 HSPA1 HSX70;CLH17 CLTCL2 KIAA0034;None
7271	ARNTL-NPAS2 complex	Human	MOP3-MOP4 complex	brain	O00327;Q99743	406;4862	MI:0018-two hybrid;MI:0413-electrophoretic mobility shift assay	GO:0009299	mRNA transcription	11.02.03	mRNA synthesis	9576906	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Aryl hydrocarbon receptor nuclear translocator-like protein 1;Neuronal PAS domain-containing protein 2	ARNTL;NPAS2	BHLHE5 BMAL1 MOP3 PASD3;BHLHE9 MOP4 PASD4
7272	Core clock complex	Human	ARNTL-CLOCK complex; MOP3-CLOCK complex; CLOCK-BMAL1 complex	brain	O00327;O15516	406;9575	MI:0018-two hybrid;MI:0413-electrophoretic mobility shift assay	GO:0009299	mRNA transcription	11.02.03	mRNA synthesis	9576906	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Aryl hydrocarbon receptor nuclear translocator-like protein 1;Circadian locomoter output cycles protein kaput	ARNTL;CLOCK	BHLHE5 BMAL1 MOP3 PASD3;BHLHE8,KIAA0334
7273	ARNTL-HIF1A complex	Human	MOP3-HIF1-alpha complex	brain	O00327;Q16665	406;3091	MI:0018-two hybrid;MI:0413-electrophoretic mobility shift assay	GO:0003677	DNA binding	16.03.01	DNA binding	9576906	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Aryl hydrocarbon receptor nuclear translocator-like protein 1;Hypoxia-inducible factor 1-alpha	ARNTL;HIF1A	BHLHE5 BMAL1 MOP3 PASD3;BHLHE78 MOP1 PASD8
7274	ARNTL-EPAS1 complex	Human	MOP3-HIF2-alpha complex	brain	O00327;Q99814	406;2034	MI:0018-two hybrid;MI:0413-electrophoretic mobility shift assay	GO:0003677	DNA binding	16.03.01	DNA binding	9576906	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Aryl hydrocarbon receptor nuclear translocator-like protein 1;Endothelial PAS domain-containing protein 1	ARNTL;EPAS1	BHLHE5 BMAL1 MOP3 PASD3;BHLHE73 HIF2A MOP2 PASD2
7275	BCL2-CISD2 complex	Human	BCL2-NAF1 complex	H1299 HA-BCL-2b5 cells	P10415;Q8N5K1	596;493856	MI:0019-coimmunoprecipitation	GO:0006914;GO:0005783	autophagy;endoplasmic reticulum	70.07	endoplasmic reticulum	20010695	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Apoptosis regulator Bcl-2;CDGSH iron-sulfur domain-containing protein 2	BCL2;CISD2	None;CDGSH2 ERIS ZCD2
7277	Carboxypeptidase N	Human	Kininase I; Arginine carboxypeptidase	blood plasma	P15169;P22792	1369;1370	MI:0071-molecular sieving	GO:0010815;GO:0004180	bradykinin catabolic process;carboxypeptidase activity	None	None	6750606	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Carboxypeptidase N catalytic chain;Carboxypeptidase N subunit 2	CPN1;CPN2	ACBP;ACBP
7278	CTNNB1-GSK3B-PHF19 complex	Human	PCL3s-beta-catenin-GSK3beta complex	Hepatocellular carcinoma (HCC) cells	P35222;P49841;Q5T6S3-2	1499;2932;26147	MI:0019-coimmunoprecipitation	GO:1904863;GO:0005737	regulation of beta-catenin-TCF complex assembly;cytoplasm	70.03	cytoplasm	29483096	Probably human PCL3s regulated beta-catenin/TCFsignaling in the cytoplasm but not in the nucleus (PMID:29483096)	None	PCL3s is the short splice variant of PHF19 (PCL3) (Q5T6S3-2).	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Catenin beta-1;Glycogen synthase kinase-3 beta;Isoform 2 of PHD finger protein 19	CTNNB1;GSK3B;PHF19	CTNNB;None;PCL3
7279	CTNNB1-BTRC-PHF19 (short isoform) complex	Human	PCL3s-beta-catenin-beta-TrC complex	Hepatocellular carcinoma (HCC) cells	P35222;Q5T6S3-2;Q9Y297	1499;26147;8945	MI:0019-coimmunoprecipitation	GO:0031396	regulation of protein ubiquitination	None	None	29483096	None	None	PCL3s is the short splice variant of PHF19 (PCL3) (Q5T6S3-2).	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Catenin beta-1;Isoform 2 of PHD finger protein 19;F-box/WD repeat-containing protein 1A	CTNNB1;PHF19;BTRC	CTNNB;PCL3;BTRCP FBW1A FBXW1A
7281	BIN1-EHBP1-RAB8A complex	Human	None	HEK cells	O00499;P61006;Q8NDI1	274;4218;23301	MI:0416-fluorescence microscopy	GO:0051223	regulation of protein transport	None	None	26833786	Rab8, EHBP1L1, and Bin1 play a role in apical protein transport and that Rab8 may play an additional role in basolateral transport in small intestine polarized epithelial cells (PMID:26833786).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Myc box-dependent-interacting protein 1;Ras-related protein Rab-8A;EH domain-binding protein 1	BIN1;RAB8A;EHBP1	AMPHL;MEL RAB8;KIAA0903,NACSIN
7282	FEN1-WRN complex	Human	None	None	P39748;Q14191	2237;7486	MI:0096-pull down	GO:0032201	telomere maintenance via semi-conservative replication	None	None	24608430	Mutation FEN1 E359K from person with a history of family breast cancer disrupts FEN1/WRN interaction and gap dependent endonuclease activity, which impairs the cell\u2019s ability to counteract replication stresses. which impairs the cell\u2019s ability to counteract replication stresses (PMID:24608430)	None	None	Homo sapiens (Human);Homo sapiens (Human)	Flap endonuclease 1;Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	FEN1;WRN	RAD2;RECQ3 RECQL2
7283	ETS1-PRX1 complex	Human	None	Human oral precancerous lesion dysplastic oral keratinocyte (DOK) cells	P14921;P54821	2113;5396	MI:0019-coimmunoprecipitation	GO:0006355;GO:0035094	regulation of DNA-templated transcription;response to nicotine	11.02.03.04	transcriptional control	29275566	In oral precancerous lesion cells, Ets1 directly regulates Prx1 expression and nicotine might promote the development of oral precancerous lesion by magnifying the positive feedback signal pathway between Ets1 and Prx1 (PMID:29275566)	OMIM:188890 Tobacco addiction (PMID:29275566)	None	Homo sapiens (Human);Homo sapiens (Human)	Protein C-ets-1;Paired mesoderm homeobox protein 1	ETS1;PRRX1	EWSR2;PMX1
7284	GSK3B-HSP90AA1-PKM2 complex	Human	HSP90-PKM2-GSK-3beta complex	None	P07900;P14618;P49841	3320;5315;2932	MI:0019-coimmunoprecipitation	GO:0001932	regulation of protein phosphorylation	None	None	29262861	HSP90 led to PKM2 phosphorylation at Thr-328 induced by HSP90 was dependent on GSK-3beta(PMID:29262861)	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Heat shock protein HSP 90-alpha;Pyruvate kinase PKM;Glycogen synthase kinase-3 beta	HSP90AA1;PKM;GSK3B	HSP90A HSPC1 HSPCA;OIP3 PK2 PK3 PKM2;None
7285	HEXIM1-DNA-PK-paraspeckle components-ribonucleoprotein complex	Human	HDP-RNP complex	HeLa S3 cells	O94992;P12956;P13010;P23246;P43243;P78527;Q15233;Q8WXF1;Q96PK6	10614;2547;7520;6421;9782;5591;4841;55269;100526737	MI:0007-anti tag coimmunoprecipitation;MI:0676-tandem affinity purification	GO:0045088;GO:0005634	regulation of innate immune response;nucleus	70.10	nucleus	28712728	HEXIM1 interacts with the long non-coding RNA NEAT1 to create the necessary platform for the assembly of the HDP-RNP (PMID:28712728).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein HEXIM1;X-ray repair cross-complementing protein 6;X-ray repair cross-complementing protein 5;Splicing factor, proline- and glutamine-rich;Matrin-3;DNA-dependent protein kinase catalytic subunit;Non-POU domain-containing octamer-binding protein;Paraspeckle component 1;RNA-binding protein 14	HEXIM1;XRCC6;XRCC5;SFPQ;MATR3;PRKDC;NONO;PSPC1;RBM14	CLP1, EDG1, HIS1, MAQ1;G22P1;G22P2;PSF;KIAA0723;HYRC HYRC1;NRB54;PSP1;SIP
7286	AIP4-DTX3L complex	Human	None	HeLa cells	Q8TDB6;Q96J02	151636;83737	MI:0006-anti bait coimmunoprecipitation	GO:0016197;GO:0005769;GO:0016567	endosomal transport;early endosome;protein ubiquitination	14.07.05	modification by ubiquitination, deubiquitination	24790097	DTX3L interacts directly with AIP4 (ITCH) upon CXCR4 activation on early endosomes (PMID:24790097).	None	None	Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase DTX3L;E3 ubiquitin-protein ligase Itchy homolog	DTX3L;ITCH	BBAP;None
7287	SIMPLE-HRS-STAM1 complex	Human	SIMPLE-HGS-STAM1 complex	HeLa cells	O14964;Q92783;Q99732	9146;8027;9516	MI:0019-coimmunoprecipitation	GO:0008333;GO:0005769;GO:0070371	endosome to lysosome transport;early endosome;ERK1 and ERK2 cascade	None	None	23166352	None	Mutations in SIMPLE (small integral membrane protein of lysosome/late endosome) cause Charcot-Marie-Tooth disease (CMT), type 1C. These loss of function mutations impair endosomal trafficking and lead to prolonged ERK1/2 signaling downstream of ErbB activation.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Hepatocyte growth factor-regulated tyrosine kinase substrate;Signal transducing adapter molecule 1;Lipopolysaccharide-induced tumor necrosis factor-alpha factor	HGS;STAM;LITAF	HRS;STAM1;PIG7 SIMPLE
7288	ANGPTL4-LRP6-SDC1 complex	Human	None	HepG2 cells	O75581;P18827;Q9BY76	4040;6382;51129	MI:0096-pull down	GO:0060828	regulation of canonical Wnt signaling pathway	None	None	29017031	ANGPTL4 as a Wnt signaling antagonist  binds to syndecans and forms a ternary complex with the Wnt co-receptor Lipoprotein receptor-related protein 6 (LRP6). This protein complex is internalized via clathrin-mediated endocytosis and degraded in lysosomes, leading to attenuation of Wnt/?-catenin signaling (PMID:29017031).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Low-density lipoprotein receptor-related protein 6;Syndecan-1;Angiopoietin-related protein 4	LRP6;SDC1;ANGPTL4	None;SDC;ARP4 HFARP PGAR
7289	ANGPTL4-LRP6-SDC2 complex	Human	None	HepG2 cells	O75581;P34741;Q9BY76	4040;6383;51129	MI:0096-pull down	GO:0060828	regulation of canonical Wnt signaling pathway	None	None	29017031	ANGPTL4 as a Wnt signaling antagonist binds to syndecans and forms a ternary complex with the Wnt co-receptor Lipoprotein receptor-related protein 6 (LRP6). This protein complex is internalized via clathrin-mediated endocytosis and degraded in lysosomes, leading to attenuation of Wnt/?-catenin signaling (PMID:29017031).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Low-density lipoprotein receptor-related protein 6;Syndecan-2;Angiopoietin-related protein 4	LRP6;SDC2;ANGPTL4	None;HSPG1;ARP4 HFARP PGAR
7290	ANGPTL4-LRP6-SDC4 complex	Human	None	HepG2 cells	O75581;P31431;Q9BY76	4040;6385;51129	MI:0096-pull down	GO:0060828	regulation of canonical Wnt signaling pathway	None	None	29017031	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Low-density lipoprotein receptor-related protein 6;Syndecan-4;Angiopoietin-related protein 4	LRP6;SDC4;ANGPTL4	None;None;ARP4 HFARP PGAR
7291	EIF2B2-EIF2B3-EIF2B4-EIF2B5 complex	Human	eIF2B(beta, gamma, delta, epsilon) complex	None	P49770;Q13144;Q9NR50;Q9UI10	8892;8893;8891;8890	MI:0071-molecular sieving	GO:0003743;GO:0006446	translation initiation factor activity;regulation of translational initiation	None	None	24532666	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Translation initiation factor eIF-2B subunit beta;Translation initiation factor eIF-2B subunit epsilon;Translation initiation factor eIF-2B subunit gamma;Translation initiation factor eIF-2B subunit delta	EIF2B2;EIF2B5;EIF2B3;EIF2B4	EIF2BB;EIF2BE;None;EIF2BD
7292	EIF2B1-EIF2B2-EIF2B3-EIF2B4-EIF2B5 complex	Human	EIF2B(alpha, beta, gamma, delta, epsilon) complex	None	P49770;Q13144;Q14232;Q9NR50;Q9UI10	8892;8893;1967;8891;8890	MI:0071-molecular sieving	GO:0006446;GO:0003743	regulation of translational initiation;translation initiation factor activity	None	None	24532666	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Translation initiation factor eIF-2B subunit beta;Translation initiation factor eIF-2B subunit epsilon;Translation initiation factor eIF-2B subunit alpha;Translation initiation factor eIF-2B subunit gamma;Translation initiation factor eIF-2B subunit delta	EIF2B2;EIF2B5;EIF2B1;EIF2B3;EIF2B4	EIF2BB;EIF2BE;EIF2BA;None;EIF2BD
7294	JUND-TAP1 complex	Human	None	T-cells	P17535;Q03518	3727;6890	MI:0019-coimmunoprecipitation	GO:0003713	transcription coactivator activity	None	None	8939957	None	None	Since Jund and Tap1 from gibbon were not available in the UniProt database at the time of annotation, the orthologous proteins from human were used.	Homo sapiens (Human);Homo sapiens (Human)	Transcription factor JunD;Antigen peptide transporter 1	JUND;TAP1	None;ABCB2 PSF1 RING4 Y3
7295	ERCC1-RPA1-XPA complex	Human	None	None	P07992;P23025;P27694	2067;7507;6117	MI:0107-surface plasmon resonance	GO:0006282	regulation of DNA repair	None	None	8972858	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA excision repair protein ERCC-1;DNA repair protein complementing XP-A cells;Replication protein A 70 kDa DNA-binding subunit	ERCC1;XPA;RPA1	None;XPAC;REPA1 RPA70
7296	PRT1-RGP1 complex	Human	None	None	P55884;Q92546	8662;9827	MI:0019-coimmunoprecipitation	GO:0006417	regulation of translation	12.07	translational control	9694884	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Eukaryotic translation initiation factor 3 subunit B;RAB6A-GEF complex partner protein 2	EIF3B;RGP1	EIF3S9;KIAA0258
7298	ACTB-ANP32A-C1QBP-PSMA1-PTMA-PSMA1 complex	Human	C34 complex	proliferating FT Jurkat cells	P06454;P25786;P39687;P60709;Q00325;Q07021	5757;5682;8125;60;5250;708	MI:0030-cross-linking study	GO:0008283;GO:0043066;GO:0046902	cell population proliferation;negative regulation of apoptotic process;regulation of mitochondrial membrane permeability	40.10.02.01	anti-apoptosis	29106904	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Prothymosin alpha;Proteasome subunit alpha type-1;Acidic leucine-rich nuclear phosphoprotein 32 family member A;Actin, cytoplasmic 1;Phosphate carrier protein, mitochondrial;Complement component 1 Q subcomponent-binding protein, mitochondrial	PTMA;PSMA1;ANP32A;ACTB;SLC25A3;C1QBP	TMSA;HC2 NU PROS30 PSC2;C15orf1 LANP MAPM PHAP1;None;PHC;GC1QBP HABP1 SF2P32
7299	ANP32A-ANP32B-PSMA3-PTMA-SLC25A5 complex	Human	C30 complex	proliferating FT Jurkat cells	P05141;P06454;P25788;P39687;Q92688	292;5757;5684;8125;10541	MI:0030-cross-linking study	GO:0008283;GO:0043066;GO:0046902	cell population proliferation;negative regulation of apoptotic process;regulation of mitochondrial membrane permeability	40.10.02.01	anti-apoptosis	29106904	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	ADP/ATP translocase 2;Prothymosin alpha;Proteasome subunit alpha type-3;Acidic leucine-rich nuclear phosphoprotein 32 family member A;Acidic leucine-rich nuclear phosphoprotein 32 family member B	SLC25A5;PTMA;PSMA3;ANP32A;ANP32B	AAC2 ANT2;TMSA;HC8 PSC8;C15orf1 LANP MAPM PHAP1;APRIL,PHAPI2
7300	PARD3B-PARD6A-PRKCI complex	Human	None	HeLa cells	P41743;Q8TEW8;Q9NPB6	5584;117583;50855	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0043297	apical junction assembly	None	None	11260256	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein kinase C iota type;Partitioning defective 3 homolog B;Partitioning defective 6 homolog alpha	PRKCI;PARD3B;PARD6A	DXS1179E;ALS2CR19 PAR3B PAR3L;PAR6A
7304	HIC1-PCL3L-PCR2 complex	Human	None	HEK293T cells	O75530;Q14526;Q15022;Q15910;Q5T6S3	8726;3090;23512;2146;26147	MI:0019-coimmunoprecipitation	GO:0016571;GO:0045892	histone methylation;negative regulation of DNA-templated transcription	11.02.03.04.03	transcription repression	22315224	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Polycomb protein EED;Hypermethylated in cancer 1 protein;Polycomb protein SUZ12;Histone-lysine N-methyltransferase EZH2;PHD finger protein 19	EED;HIC1;SUZ12;EZH2;PHF19	None;ZBTB29;CHET9 JJAZ1 KIAA0160;KMT6;PCL3
7305	Cytochrome c oxidase including assembly factors (COX, PET100, PET117, MR-1S)	Human	COX including assembly factors; complex IV including assembly factors	143B cells and C-124 human skin fibroblasts	O00483;P00395;P00403;P00414;P09669;P0DJ07;P10176;P10606;P12074;P13073;P14406;P14854;P15954;P20674;P24311;Q6UWS5;Q8N490-2;Q9Y241	4697;4512;4513;4514;1345;100131801;1351;1329;1337;1327;1347;1340;1350;9377;1349;100303755;25953;25994	MI:0069-mass spectrometry studies of complexes;MI:0276-blue native page	GO:0004129;GO:0005743;GO:0022904	cytochrome-c oxidase activity;mitochondrial inner membrane;respiratory electron transport chain	70.16.05;02.11.07;20.01.15	mitochondrial inner membrane;regulation of electron transport and membrane-associated energy conservation;electron transport	28199844	None	None	MR-1S is a splice variant of PNKD (MR1).	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cytochrome c oxidase subunit NDUFA4;Cytochrome c oxidase subunit 1;Cytochrome c oxidase subunit 2;Cytochrome c oxidase subunit 3;Cytochrome c oxidase subunit 6C;Protein PET100 homolog, mitochondrial;Cytochrome c oxidase subunit 8A, mitochondrial;Cytochrome c oxidase subunit 5B, mitochondrial;Cytochrome c oxidase subunit 6A1, mitochondrial;Cytochrome c oxidase subunit 4 isoform 1, mitochondrial;Cytochrome c oxidase subunit 7A2, mitochondrial;Cytochrome c oxidase subunit 6B1;Cytochrome c oxidase subunit 7C, mitochondrial;Cytochrome c oxidase subunit 5A, mitochondrial;Cytochrome c oxidase subunit 7B, mitochondrial;Protein PET117 homolog, mitochondrial;Isoform 2 of Probable hydrolase PNKD;HIG1 domain family member 1A, mitochondrial	NDUFA4;MT-CO1;MT-CO2;MT-CO3;COX6C;PET100;COX8A;COX5B;COX6A1;COX4I1;COX7A2;COX6B1;COX7C;COX5A;COX7B;PET117;PNKD;HIGD1A	None;COI COXI MTCO1;COII COX2 COXII MTCO2;COIII COXIII MTCO3;None;C19orf79;COX8,COX8L;None;COX6AL;COX4;COX7AL;COX6B;None;None;None;None;KIAA1184 MR1 TAHCCP2;HIG1
7309	END1-ENDRA complex	Human	None	None	P05305;P25101	1906;1909	MI:0096-pull down	GO:0004962	endothelin receptor activity	None	None	7509919	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Endothelin-1;Endothelin-1 receptor	EDN1;EDNRA	None;ETA,ETRA
7310	IL10-IL10RA complex	Human	None	JY cells	P22301;Q13651	3586;3587	MI:0030-cross-linking study	GO:0019221	cytokine-mediated signaling pathway	None	None	8407942	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Interleukin-10;Interleukin-10 receptor subunit alpha	IL10;IL10RA	None;IL10R
7311	CRY1-Core clock complex	Human	ARNTL-CLOCK-CRY1 complex; BMAL1-CLOCK-CRY1 complex	fibroblasts	O00327;O15516;Q16526	406;9575;1407	MI:0019-coimmunoprecipitation	GO:0007623	circadian rhythm	None	None	28388406	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Aryl hydrocarbon receptor nuclear translocator-like protein 1;Circadian locomoter output cycles protein kaput;Cryptochrome-1	ARNTL;CLOCK;CRY1	BHLHE5 BMAL1 MOP3 PASD3;BHLHE8,KIAA0334;PHLL1
7312	CTNNB1-ESR1 complex	Human	beta-Catenin-ERalpha complex	osteoblasts (hFOB 1.19)	P03372;P35222	2099;1499	MI:0019-coimmunoprecipitation	GO:0009299;GO:0070341	mRNA transcription;fat cell proliferation	11.02.03	mRNA synthesis	17852416	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Estrogen receptor;Catenin beta-1	ESR1;CTNNB1	ESR NR3A1;CTNNB
7313	ESYT1-ESYT2 complex	Human	None	HeLa cells	A0FGR8;Q9BSJ8	57488;23344	MI:0019-coimmunoprecipitation	GO:0005783	endoplasmic reticulum	70.07	endoplasmic reticulum	23791178	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Extended synaptotagmin-2;Extended synaptotagmin-1	ESYT2;ESYT1	FAM62B,KIAA1228;FAM62A KIAA0747 MBC2
7314	ESYT1-ESYT3 complex	Human	None	HeLa cells	A0FGR9;Q9BSJ8	83850;23344	MI:0019-coimmunoprecipitation	GO:0005783	endoplasmic reticulum	70.07	endoplasmic reticulum	23791178	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Extended synaptotagmin-3;Extended synaptotagmin-1	ESYT3;ESYT1	FAM62C;FAM62A KIAA0747 MBC2
7316	NFKB1-STAT3 complex	Human	None	Mesangial cells	P19838;P40763	4790;6774	MI:0019-coimmunoprecipitation	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	None	None	12057007	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Nuclear factor NF-kappa-B p105 subunit;Signal transducer and activator of transcription 3	NFKB1;STAT3	None;APRF
7317	RELA-STAT3 complex	Human	None	Mesangial cells	P40763;Q04206	6774;5970	MI:0019-coimmunoprecipitation	GO:0060300;GO:0001228	regulation of cytokine activity;DNA-binding transcription activator activity, RNA polymerase II-specific	None	None	12057007	STAT3, via direct interactions with NF-kappaB p65, serves as a dominant-negative inhibitor of NF-kappaB activity to suppress indirectly cytokine induction of the iNOS promoter in mesangial cells(PMID:12057007)	None	None	Homo sapiens (Human);Homo sapiens (Human)	Signal transducer and activator of transcription 3;Transcription factor p65	STAT3;RELA	APRF;NFKB3
7318	CTNNB1-DDX5-HDGF complex	Human	HDGF-DDX5-beta-catenin complex	Lung adenocarcinoma cells (LADC)	P17844;P35222;P51858	1655;1499;3068	MI:0019-coimmunoprecipitation	GO:0001558;GO:2001023	regulation of cell growth;regulation of response to drug	None	None	28751441	miR-296-3p-PRKCA-FAK-Ras-c-Myc feedback loop modulated by HDGF/DDX5/beta-catenin complex attenuates cell growth, metastasis, and chemoresistance in LADC (PMID:28751441)	OMIM:211980 Lung cancer (PMID:28751441)	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Probable ATP-dependent RNA helicase DDX5;Catenin beta-1;Hepatoma-derived growth factor	DDX5;CTNNB1;HDGF	G17P1 HELR HLR1;CTNNB;HMG1L2
7319	CLEC4E-FCER1G complex	Human	MINCLE-Fc epsilon RI gamma complex	None	P30273;Q9ULY5	2207;26253	MI:0096-pull down	GO:0050776;GO:0038094	regulation of immune response;Fc-gamma receptor signaling pathway	None	None	28751441	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	High affinity immunoglobulin epsilon receptor subunit gamma;C-type lectin domain family 4 member E	FCER1G;CLEC4E	None;CLECSF9,MINCLE
7320	CLEC4E-MS4A2 complex	Human	MINCLE-FcepsilonRIbeta complex	None	Q01362;Q9ULY5	2206;26253	MI:0096-pull down	GO:0050776	regulation of immune response	None	None	28751441	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	High affinity immunoglobulin epsilon receptor subunit beta;C-type lectin domain family 4 member E	MS4A2;CLEC4E	APY FCER1B IGER;CLECSF9,MINCLE
7324	HINT1-TIP60 complex	Human	None	HEK293 cells	P49773;Q92993	3094;10524	MI:0007-anti tag coimmunoprecipitation	GO:0045893;GO:0042981	positive regulation of DNA-templated transcription;regulation of apoptotic process	11.02.03.04.01	transcription activation	16835243	Hint1 forms a complex with Tip60 and is associated with the Bax promoter (PMID:16835243).	None	None	Homo sapiens (Human);Homo sapiens (Human)	Adenosine 5'-monophosphoramidase HINT1;Histone acetyltransferase KAT5	HINT1;KAT5	HINT PKCI1 PRKCNH1;HTATIP, TIP60
7325	HINT1-UBC3-RBX1 complex	Human	None	293T cells; SW480 cells	P49427;P49773;P62877	997;3094;9978	MI:0019-coimmunoprecipitation;MI:0096-pull down	None	None	None	None	19112177	HINT1 inhibits the ubiquitylation of p27 by binding to the SCF (SKP2) ubiquitin ligase complex and interfering with recruitment of the E2 enzyme CDC34/Ubc3 by Rbx1/Roc1 (PMID:19112177).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Ubiquitin-conjugating enzyme E2 R1;Adenosine 5'-monophosphoramidase HINT1;E3 ubiquitin-protein ligase RBX1	CDC34;HINT1;RBX1	UBCH3 UBE2R1;HINT PKCI1 PRKCNH1;RNF75 ROC1
7326	HINT1-SP1 complex	Human	None	HEK293T cells	P08047;P49773	6667;3094	MI:0096-pull down	GO:0045892	negative regulation of DNA-templated transcription	11.02.03.04.03	transcription repression	19112177	HINT1 forms a complex with Sp1 on the Src promoter and inhibits the expression of Src (PMID:19112177).	None	None	Homo sapiens (Human);Homo sapiens (Human)	Transcription factor Sp1;Adenosine 5'-monophosphoramidase HINT1	SP1;HINT1	TSFP1;HINT PKCI1 PRKCNH1
7328	AML1-HIPK2-p300 complex	Human	AML1-p300-HIPK2 complex	293T cells	Q01196;Q09472;Q9H2X6	861;2033;28996	MI:0096-pull down	GO:0006355	regulation of DNA-templated transcription	11.02.03.04	transcriptional control	16917507	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Runt-related transcription factor 1;Histone acetyltransferase p300;Homeodomain-interacting protein kinase 2	RUNX1;EP300;HIPK2	AML1; CBFA2;P300;None
7329	CADM1-DLG1-MPP3-PIK3R1 complex	Human	None	Coca-2 cells	P27986;Q12959;Q13368;Q9BY67	5295;1739;4356;23705	MI:0096-pull down	GO:1900024	regulation of substrate adhesion-dependent cell spreading	None	None	25268382	MPP3 and Dlg, membrane-associated guanylate kinase homologs (MAGuK) proteins, connect CADM1 with p85 of PI3K by forming a multi-protein complex at the periphery of cells. These results suggest that trans-homophilic interaction mediated by CADM1 activates the PI3K pathway to reorganize the actin cytoskeleton and form epithelial cell structure.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Phosphatidylinositol 3-kinase regulatory subunit alpha;Disks large homolog 1;MAGUK p55 subfamily member 3;Cell adhesion molecule 1	PIK3R1;DLG1;MPP3;CADM1	GRB1;None;DLG3;IGSF4 IGSF4A NECL2 SYNCAM TSLC1
7331	RAC1-RHOA-VANGL2 complex	Human	None	HEK293T cells	P61586;P63000;Q9ULK5	387;5879;57216	MI:0019-coimmunoprecipitation	None	None	None	None	20067994	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transforming protein RhoA;Ras-related C3 botulinum toxin substrate 1;Vang-like protein 2	RHOA;RAC1;VANGL2	ARH12 ARHA RHO12;TC25;KIAA1215 STB1
7333	MICALL1-RAB13 complex	Human	None	None	P51153;Q8N3F8	5872;85377	MI:0096-pull down;MI:0397-two hybrid array	GO:0016197	endosomal transport	None	None	21795389	MICAL-L1/Rab protein complex can regulate EGFR trafficking at late endocytic pathways (PMID:21795389)	None	None	Homo sapiens (Human);Homo sapiens (Human)	Ras-related protein Rab-13;MICAL-like protein 1	RAB13;MICALL1	None;KIAA1668,MIRAB13
7336	FRMD7(FL)-FRMD7(S) complex	Human	FRMD7(isoform FL)-FRMD7(isoform S) complex	NE2 cells	Q6ZUT3-1;Q6ZUT3-2	90167;90167	MI:0019-coimmunoprecipitation	GO:0010975	regulation of neuron projection development	None	None	22128244	None	None	FRMD7 isoform FL and FRMD7 isoform S are splice variants of FRMD7.	Homo sapiens (Human);Homo sapiens (Human)	Isoform 1 of FERM domain-containing protein 7;Isoform 2 of FERM domain-containing protein 7	FRMD7;FRMD7	None;None
7337	AUF1(p45)-ZFP36 complex	Human	AUF1(isoform p45)-TTP complex	None	P26651;Q14103	7538;3184	MI:0019-coimmunoprecipitation	GO:1905214	regulation of RNA binding	None	None	22203679	AUF1p45, but not AUF1p37, increased TTP binding affinity for RNA ?5-fold. These data suggest that certain isoforms of AUF1 can serve as \u201cco-activators\u201d of TTP family protein binding to RNA (PMID:22203679)	None	None	Homo sapiens (Human);Homo sapiens (Human)	mRNA decay activator protein ZFP36;Heterogeneous nuclear ribonucleoprotein D0	ZFP36;HNRNPD	G0S24 NUP475 RNF162A TIS11A TTP;AUF1 HNRPD
7338	HNRNPD(p45)-ZFP36L1 complex	Human	AUF1(isoform p45)-ZFP36L1 complex	None	Q07352;Q14103	677;3184	MI:0019-coimmunoprecipitation	None	None	None	None	22203679	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	mRNA decay activator protein ZFP36L1;Heterogeneous nuclear ribonucleoprotein D0	ZFP36L1;HNRNPD	BERG36 BRF1 ERF1 RNF162B TIS11B;AUF1 HNRPD
7340	HNRNPD(p45)-ZFP36L2 complex	Human	AUF1(isoform p45)-ZFP36L2 complex	None	P47974;Q14103	678;3184	MI:0019-coimmunoprecipitation	None	None	None	None	22203679	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	mRNA decay activator protein ZFP36L2;Heterogeneous nuclear ribonucleoprotein D0	ZFP36L2;HNRNPD	ERF2 RNF162C TIS11D;AUF1 HNRPD
7341	CTNNAL1-DNTA complex	Human	None	HEK293T	Q9UBT7;Q9Y4J8	8727;1837	MI:0019-coimmunoprecipitation	None	None	None	None	22577143	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Alpha-catulin;Dystrobrevin alpha	CTNNAL1;DTNA	None;DRP3
7342	DHCR24-DHCR7 complex	Human	None	human genes DHCR7 and DHCR24 expressed in CHO-7 cells	Q15392;Q9UBM7	1718;1717	MI:0019-coimmunoprecipitation	GO:0006695;GO:0060556	cholesterol biosynthetic process;regulation of vitamin D biosynthetic process	None	None	25637936	The terminal enzymes of cholesterol synthesis, DHCR24 and DHCR7, interact physically and functionally. Overexpression of DHCR24 enhances DHCR7 activity, but only when a functional form of DHCR24 is used. DHCR7 is important for both cholesterol and vitamin D synthesis. A novel layer of regulation was identified, whereby its activity is controlled by DHCR24.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Delta(24)-sterol reductase;7-dehydrocholesterol reductase	DHCR24;DHCR7	KIAA0018;D7SR
7344	NLGN1-NRXN1 complex	Human	Neurexin-neuroligin synaptic complex	None	Q8N2Q7;Q9ULB1	22871;9378	MI:0019-coimmunoprecipitation	None	None	None	None	26078884	NX/NL synaptic complex is intrinsically involved in the regulation of DISC1 function, thus contributing to a better understanding of the pathology of schizophrenia (PMID:26078884)	None	None	Homo sapiens (Human);Homo sapiens (Human)	Neuroligin-1;Neurexin-1	NLGN1;NRXN1	KIAA1070;KIAA0578
7345	DISC1-TRAK1 complex	Human	None	HEK293 cells, SH-SY5Y cells	Q9NRI5;Q9UPV9	27185;22906	MI:0019-coimmunoprecipitation	GO:0051646	mitochondrion localization	None	None	24092329	It is likely that DISC1 directly influences directional mitochondrial movement by complexing with TRAK1 and Miro1 in neurons (PMID:24092329).	None	None	Homo sapiens (Human);Homo sapiens (Human)	Disrupted in schizophrenia 1 protein;Trafficking kinesin-binding protein 1	DISC1;TRAK1	KIAA0457;KIAA1042 OIP106
7346	DISC1-RHOT1 complex	Human	DISC1-MIRO1 complex	None	Q8IXI2;Q9NRI5	55288;27185	MI:0019-coimmunoprecipitation	GO:0051646	mitochondrion localization	None	None	24092329	It is likely that DISC1 directly influences directional mitochondrial movement by complexing with TRAK1 and Miro1 in neurons(PMID:24092329).	None	None	Homo sapiens (Human);Homo sapiens (Human)	Mitochondrial Rho GTPase 1;Disrupted in schizophrenia 1 protein	RHOT1;DISC1	ARHT1;KIAA0457
7349	MTR4-RBM7-ZCCHC8 complex	Human	NEXT complex, Nuclear exosome targeting	None	P42285;Q6NZY4;Q9Y580	23517;55596;10179	MI:0019-coimmunoprecipitation	None	None	None	None	21855801	NEXT complex targets promoter upstream transcripts for exosomal degradation (PMID:21855801).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Exosome RNA helicase MTR4;Zinc finger CCHC domain-containing protein 8;RNA-binding protein 7	MTREX;ZCCHC8;RBM7	DOB1 KIAA0052 MTR4 SKIV2L2;None;None
7351	GDF15-ERBB2 complex	Human	None	cervical cancer cells	P04626;Q99988	2064;9518	MI:0019-coimmunoprecipitation	GO:0043408;GO:0070372;GO:0008283	regulation of MAPK cascade;regulation of ERK1 and ERK2 cascade;cell population proliferation	None	None	29636108	GDF15 promoted the proliferation of cervical cancer cells via the up-regulation of CyclinD1 and CyclinE1 and the down-regulation of p21 through both the PI3K/AKT and MAPK/ERK signaling pathways in a complex with ErbB2 (PMID:29636108).	OMIM:603956 Cervical cancer(PMID:29636108)	None	Homo sapiens (Human);Homo sapiens (Human)	Receptor tyrosine-protein kinase erbB-2;Growth/differentiation factor 15	ERBB2;GDF15	HER2 MLN19 NEU NGL;MIC1 PDF PLAB PTGFB
7352	PARP1-LIG3 complex	Human	None	None	P09874;P49916	142;3980	MI:0045-experimental interaction detection	None	None	None	None	29632340	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Poly [ADP-ribose] polymerase 1;DNA ligase 3	PARP1;LIG3	ADPRT PPOL;None
7354	ASXL1-HCFC1-OGT complex	Human	None	HEK293T cell	O15294;P51610;Q8IXJ9	8473;3054;171023	MI:0019-coimmunoprecipitation	GO:0051568;GO:0045893	histone H3-K4 methylation;positive regulation of DNA-templated transcription	11.02.03.04.01	transcription activation	29556021	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit;Host cell factor 1;Polycomb group protein ASXL1	OGT;HCFC1;ASXL1	None;HCF1, HFC1;KIAA0978
7356	IL15-MFGE8 complex	Human	IL-15-lactadherin complex	HEK293 cells	P40933;Q08431	3600;4240	MI:0091-chromatography technology	None	None	None	None	29535850	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Interleukin-15;Lactadherin	IL15;MFGE8	None;None
7357	TRIM25-G3BP2 complex	Human	None	LNCaP cell lysates	Q14258;Q9UN86	7706;9908	MI:0019-coimmunoprecipitation	None	None	None	None	29379164	The overexpression of TRIM25 promoted prostate cancer cell proliferation and cell survival by modulating p53 nuclear export mechanism with G3BP2 interaction (PMID:29379164)	OMIM:176807 Prostate cancer  (PMID:29379164).	None	Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin/ISG15 ligase TRIM25;Ras GTPase-activating protein-binding protein 2	TRIM25;G3BP2	EFP RNF147 ZNF147;KIAA0660
7358	NDFIP1-NEDD4L-SLC11A2 complex	Human	NDFIP1-NEDD4\u20132-DMT1 complex	primary neurons	P49281;Q96PU5;Q9BT67	4891;23327;80762	MI:0019-coimmunoprecipitation	GO:0016567;GO:0010039;GO:0032025;GO:0030001	protein ubiquitination;response to iron ion;response to cobalt ion;metal ion transport	14.07.05	modification by ubiquitination, deubiquitination	19706893	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Natural resistance-associated macrophage protein 2;E3 ubiquitin-protein ligase NEDD4-like;NEDD4 family-interacting protein 1	SLC11A2;NEDD4L;NDFIP1	DCT1 DMT1 NRAMP2;KIAA0439,NEDL3;N4WBP5
7359	TF-TFRC complex	Human	TfR-diferric Tf complex; Transferrin-transferrin receptor complex	in vitro	P02786;P02787	7037;7018	MI:0040-electron microscopy	GO:0008199;GO:0034755;GO:0006897	ferric iron binding;iron ion transmembrane transport;endocytosis	20.09.18.09.01	endocytosis	14980223	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Transferrin receptor protein 1;Serotransferrin	TFRC;TF	None;None
7361	ARAF-PIK3R1 complex	Human	p85-A-Raf complex	None	P10398;P27986	369;5295	MI:0096-pull down	None	None	None	None	10967104	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein kinase A-Raf;Phosphatidylinositol 3-kinase regulatory subunit alpha	ARAF;PIK3R1	ARAF1 PKS PKS2;GRB1
7363	EYA1-SIX1 complex	Human	None	HEK293 cells	Q15475;Q99502	6495;2138	MI:0019-coimmunoprecipitation	GO:0072006;GO:0045664	nephron development;regulation of neuron differentiation	None	None	11734542	Eya-Six may form a complex to regulate nephron progenitor cell development before metanephric specification and are critical mesenchymal factors for inducing nephric duct development (PMID:25903664)	OMIM:602588 Branchiootic syndrome 1 (PMID:11734542)	None	Homo sapiens (Human);Homo sapiens (Human)	Homeobox protein SIX1;Eyes absent homolog 1	SIX1;EYA1	None;None
7364	EYA1-SIX2 complex	Human	None	HEK293	Q99502;Q9NPC8	2138;10736	MI:0019-coimmunoprecipitation	GO:0072006;GO:0045664	nephron development;regulation of neuron differentiation	None	None	11734542	Eya-Six may form a complex to regulate nephron progenitor cell development before metanephric specification and are critical mesenchymal factors for inducing nephric duct development (PMID:25903664)	None	None	Homo sapiens (Human);Homo sapiens (Human)	Eyes absent homolog 1;Homeobox protein SIX2	EYA1;SIX2	None;None
7366	KATNA1-KATNAL1-KATNB1-KATNBL1 complex	Human	Katanin complex	None	O75449;Q9BVA0;Q9BW62;Q9H079	11104;10300;84056;79768	MI:0096-pull down	GO:0033043	regulation of organelle organization	None	None	26714646	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Katanin p60 ATPase-containing subunit A1;Katanin p80 WD40 repeat-containing subunit B1;Katanin p60 ATPase-containing subunit A-like 1;KATNB1-like protein 1	KATNA1;KATNB1;KATNAL1;KATNBL1	None;None;None;C15orf29
7367	ASH2L-KDM6B-KDM6B-WDR5 complex	Human	None	HEK293 cells	O15054;P61964;Q15291;Q9UBL3	23135;11091;5929;9070	MI:0019-coimmunoprecipitation	None	None	None	None	17825402	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Lysine-specific demethylase 6B;WD repeat-containing protein 5;Retinoblastoma-binding protein 5;Set1/Ash2 histone methyltransferase complex subunit ASH2	KDM6B;WDR5;RBBP5;ASH2L	JMJD3,KIAA0346;BIG3;RBQ3;ASH2L1
7368	Ubiquitin E3 ligase (CUL3, KEAP1, RBX1)	Human	None	None	P62877;Q13618;Q14145	9978;8452;9817	MI:0019-coimmunoprecipitation	GO:0043161;GO:0031463	proteasome-mediated ubiquitin-dependent protein catabolic process;Cul3-RING ubiquitin ligase complex	14.13.01.01	proteasomal degradation (ubiquitin/proteasomal pathway)	15983046	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase RBX1;Cullin-3;Kelch-like ECH-associated protein 1	RBX1;CUL3;KEAP1	RNF75 ROC1;KIAA0617;INRF2 KIAA0132 KLHL19
7370	CUL3-KCTD11 complex	Human	None	None	Q13618;Q693B1	8452;147040	MI:0071-molecular sieving	None	None	None	None	25974686	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cullin-3;BTB/POZ domain-containing protein KCTD11	CUL3;KCTD11	KIAA0617;C17orf36 REN
7371	CUL3-KCTD6 complex	Human	None	None	Q13618;Q8NC69	8452;200845	MI:0071-molecular sieving	None	None	None	None	25974686	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cullin-3;BTB/POZ domain-containing protein KCTD6	CUL3;KCTD6	KIAA0617;None
7372	BRD7-SWI\u2013SNF complex	Human	None	HeLa S3/F1-BAF45	O14497;O14744;O96019;P51531;P51532;Q8TAQ2;Q8WUB8;Q92922;Q969G3;Q96GM5;Q9NPI1	8289;10419;86;6595;6597;6601;55274;6599;6605;6602;29117	MI:0096-pull down	GO:0045892	negative regulation of DNA-templated transcription	11.02.03.04.03	transcription repression	21447565	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	AT-rich interactive domain-containing protein 1A;Protein arginine N-methyltransferase 5;Actin-like protein 6A;Probable global transcription activator SNF2L2;Transcription activator BRG1;SWI/SNF complex subunit SMARCC2;PHD finger protein 10;SWI/SNF complex subunit SMARCC1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1;Bromodomain-containing protein 7	ARID1A;PRMT5;ACTL6A;SMARCA2;SMARCA4;SMARCC2;PHF10;SMARCC1;SMARCE1;SMARCD1;BRD7	BAF250 BAF250A C1orf4 OSA1 SMARCF1;HRMT1L5 IBP72 JBP1 SKB1;BAF53 BAF53A INO80K;BAF190B BRM SNF2A SNF2L2;BAF190A BRG1 SNF2B SNF2L4;BAF170;BAF45A;BAF155;BAF57;BAF60A;BP75 CELTIX1
7373	BRD7-SWI\u2013SNF-SUZ12 complex	Human	None	HeLa S3 RIPA cells	P51531;P51532;Q15022;Q9NPI1;Q9NVM4	6595;6597;23512;29117;54496	MI:0019-coimmunoprecipitation	None	None	None	None	21447565	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Probable global transcription activator SNF2L2;Transcription activator BRG1;Polycomb protein SUZ12;Bromodomain-containing protein 7;Protein arginine N-methyltransferase 7	SMARCA2;SMARCA4;SUZ12;BRD7;PRMT7	BAF190B BRM SNF2A SNF2L2;BAF190A BRG1 SNF2B SNF2L4;CHET9 JJAZ1 KIAA0160;BP75 CELTIX1;KIAA1933
7374	BRD7-BAF60A-MEP50 complex	Human	None	None	Q96GM5;Q9BQA1;Q9NPI1	6602;79084;29117	MI:0096-pull down	None	None	None	None	21447565	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1;Methylosome protein 50;Bromodomain-containing protein 7	SMARCD1;WDR77;BRD7	BAF60A;MEP50 WD45;BP75 CELTIX1
7375	BRD7-EZH2-SUZ12 complex	Human	None	None	Q15022;Q15910;Q9NPI1	23512;2146;29117	MI:0096-pull down	None	None	None	None	21447565	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Polycomb protein SUZ12;Histone-lysine N-methyltransferase EZH2;Bromodomain-containing protein 7	SUZ12;EZH2;BRD7	CHET9 JJAZ1 KIAA0160;KMT6;BP75 CELTIX1
7376	BRD7-CBP-SWI\u2013SNF complex	Human	None	HeLa S3/Fl-hSWI\u2013SNF cells	O14744;P51531;P51532;Q8WUB8;Q969G3;Q9NPI1;Q9NWQ8	10419;6595;6597;55274;6605;29117;55824	MI:0096-pull down	None	None	None	None	21447565	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein arginine N-methyltransferase 5;Probable global transcription activator SNF2L2;Transcription activator BRG1;PHD finger protein 10;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1;Bromodomain-containing protein 7;Phosphoprotein associated with glycosphingolipid-enriched microdomains 1	PRMT5;SMARCA2;SMARCA4;PHF10;SMARCE1;BRD7;PAG1	HRMT1L5 IBP72 JBP1 SKB1;BAF190B BRM SNF2A SNF2L2;BAF190A BRG1 SNF2B SNF2L4;BAF45A;BAF57;BP75 CELTIX1;CBP,PAG
7377	KDM8-RCCD1 complex	Human	None	None	A6NED2;Q8N371	91433;79831	MI:0004-affinity chromatography technology;MI:0019-coimmunoprecipitation	None	None	None	None	24981860	KDM8-RCCD1 complex has a role in chromosome stability and division fidelity (PMID:24981860).	None	None	Homo sapiens (Human);Homo sapiens (Human)	RCC1 domain-containing protein 1;Bifunctional peptidase and arginyl-hydroxylase JMJD5	RCCD1;KDM8	None;JMJD5
7378	KHDC3L-NLRP5-OOEP-TLE6 complex	Human	Subcortical maternal complex	Oocytes	A6NGQ2;P59047;Q587J8;Q9H808	441161;126206;154288;79816	MI:0019-coimmunoprecipitation	GO:0009790	embryo development	None	None	25542835	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Oocyte-expressed protein homolog;NACHT, LRR and PYD domains-containing protein 5;KH domain-containing protein 3;Transducin-like enhancer protein 6	OOEP;NLRP5;KHDC3L;TLE6	C6orf156 KHDC2 OEP19;MATER,NALP5;C6orf221 ECAT1;None
7379	FYN-KHDRBS1-PLCG1 complex	Human	Fyn-PLCgamma1-Sam68 complex	HEK293 cells	P06241;P19174;Q07666	2534;5335;10657	MI:0019-coimmunoprecipitation	GO:0051252	regulation of RNA metabolic process	None	None	14647465	tr-kit (truncated form of the tyrosine kinase receptorc-kit) promotes the formation of a multimolecular complex composed of Fyn, PLCgamma1 and Sam68, which allows phosphorylation of PLCgamma1 by Fyn, and may modulate RNA metabolism (PMID:14647465)	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Tyrosine-protein kinase Fyn;1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1;KH domain-containing, RNA-binding, signal transduction-associated protein 1	FYN;PLCG1;KHDRBS1	None;PLC1;SAM68
7381	DCS complex	Human	None	HeLa cells, WERI-1 retinoblastoma cells	P26599;P31943;Q92945;Q9UKA9	5725;3187;8570;58155	MI:0019-coimmunoprecipitation;MI:0430-nucleic acid uv cross-linking assay	GO:0070054;GO:0005634	mRNA splicing, via endonucleolytic cleavage and ligation;nucleus	70.10	nucleus	11003644	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Polypyrimidine tract-binding protein 1;Heterogeneous nuclear ribonucleoprotein H;Far upstream element-binding protein 2;Polypyrimidine tract-binding protein 2	PTBP1;HNRNPH1;KHSRP;PTBP2	PTB;HNRPH HNRPH1;FUBP2;NPTB PTB PTBLP
7382	Prohibitin-HIRA complex	Human	PHB-HIRA complex	hESC cell line SHhES8 (human foreskin fibroblast cells); HEK293T cells	P35232;P54198;Q9NPG3;Q9Y6J0	5245;7290;29855;23523	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0006334	nucleosome assembly	None	None	27939217	PHB interacts with the HIRA complex (a histone H3.3 chaperone) and stabilizes the protein levels of HIRA complex components.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Prohibitin 1;Protein HIRA;Ubinuclein-1;Calcineurin-binding protein cabin-1	PHB1;HIRA;UBN1;CABIN1	PHB;DGCR1 HIR TUPLE1;None;KIAA0330
7383	OGT-HIRA complex	Human	None	HEK293T cells	O15294;P54198;Q9NPG3;Q9Y6J0	8473;7290;29855;23523	MI:0019-coimmunoprecipitation	GO:0006334;GO:2000772	nucleosome assembly;regulation of cellular senescence	None	None	27217568	OGT interacts with UBN1, modifies HIRA, and promotes nucleosome assembly of H3.3.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit;Protein HIRA;Ubinuclein-1;Calcineurin-binding protein cabin-1	OGT;HIRA;UBN1;CABIN1	None;DGCR1 HIR TUPLE1;None;KIAA0330
7384	DTX3L-PARP9 complex	Human	PARP9-DTX3L complex	HEK293T cells	Q8IXQ6;Q8TDB6	83666;151636	MI:0019-coimmunoprecipitation	GO:0016567;GO:0051607	protein ubiquitination;defense response to virus	14.07.05	modification by ubiquitination, deubiquitination	26479788	mediates ubiquitination of both host histones and viral proteases to enhance IFN-dependent immunity and thereby control viral infection.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Protein mono-ADP-ribosyltransferase PARP9;E3 ubiquitin-protein ligase DTX3L	PARP9;DTX3L	BAL BAL1;BBAP
7385	DTX3L-PARP9-STAT1 complex	Human	None	HEK293T cells	P42224;Q8IXQ6;Q8TDB6	6772;83666;151636	MI:0019-coimmunoprecipitation	GO:0051607;GO:0016567;GO:0006355	defense response to virus;protein ubiquitination;regulation of DNA-templated transcription	14.07.05;11.02.03.04	modification by ubiquitination, deubiquitination;transcriptional control	26479788	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Signal transducer and activator of transcription 1-alpha/beta;Protein mono-ADP-ribosyltransferase PARP9;E3 ubiquitin-protein ligase DTX3L	STAT1;PARP9;DTX3L	None;BAL BAL1;BBAP
7386	HIVEP3-RUNX2-WWP1 complex	Human	SHN2-RUNX2-WWP1 complex	HEK293T cells	Q13950;Q5T1R4;Q9H0M0	860;59269;11059	MI:0019-coimmunoprecipitation	GO:0070977	bone maturation	None	None	16728642	Shn3 (HIVEP3) interacts with WWP1 to enhance the ubiquitination of Runx2 (PMID:16728642).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Runt-related transcription factor 2;Transcription factor HIVEP3;NEDD4-like E3 ubiquitin-protein ligase WWP1	RUNX2;HIVEP3;WWP1	AML3 CBFA1 OSF2 PEBP2A;KBP1 KIAA1555 KRC ZAS3;None
7388	CENP-A nucleosomal complex	Human	None	HeLa cell	P07199;P33778;P49450;P62805;Q03188;Q08945;Q8N0S6;Q8NCD3;Q92674;Q96BT3;Q96H22;Q96QV6;Q96T23;Q9H3R5;Q9Y5B9	1059;3018;1058;None;1060;6749;91687;55355;2491;80152;55839;221613;51773;64946;11198	MI:0676-tandem affinity purification	GO:0005634;GO:0051276	nucleus;chromosome organization	70.10;42.10.03	nucleus;organization of chromosome structure	27499292	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Major centromere autoantigen B;Histone H2B type 1-B;Histone H3-like centromeric protein A;Histone H4;Centromere protein C;FACT complex subunit SSRP1;Centromere protein L;Holliday junction recognition protein;Centromere protein I;Centromere protein T;Centromere protein N;Histone H2A type 1-A;Remodeling and spacing factor 1;Centromere protein H;FACT complex subunit SPT16	CENPB;H2BC3;CENPA;H4C1;CENPC;SSRP1;CENPL;HJURP;CENPI;CENPT;CENPN;H2AC1;RSF1;CENPH;SUPT16H	None;H2BFF HIST1H2BB;None;H4/A H4FA HIST1H4A;CENPC1 ICEN7;FACT80;C1orf155 ICEN33;FAKTS FLEG1 URLC9;FSHPRH1 ICEN19 LRPR1;C16orf56, ICEN22;C16orf60 ICEN32;H2AFR HIST1H2AA;HBXAP XAP8;ICEN35;FACT140 FACTP140
7389	KCNA1-KCNA2-KCNAB2 complex	Human	Kv1.1-Kv1.2-Kvb2 complex	adult human spinal cord	P16389;Q09470;Q13303	3737;3736;8514	MI:0019-coimmunoprecipitation;MI:0051-fluorescence technology	GO:0005267;GO:0071805;GO:0034705;GO:0008076;GO:0005249	potassium channel activity;potassium ion transmembrane transport;potassium channel complex;voltage-gated potassium channel complex;voltage-gated potassium channel activity	None	None	11086297	Axonal K1 channels involved in normal spinal cord function are candidate targets for therapeutics, which improve sensorimotor function in spinal cord injury. Kv1.1, Kv1.2, and Kvb2 form heteromultimeric complexes at juxtaparanodal zones in myelinated fibers. The same complexes are also present in paranodal regions of some spinal cord axons, and staining with antibodies against Caspr, a component of the paranodal axoglial junction, overlaps with these paranodal K1 channels. This latter observation suggests a unique role for these channels in normal spinal cord function and may provide an explanation for the sensitivity of spinal cord to K1 channel blockers.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Potassium voltage-gated channel subfamily A member 2;Potassium voltage-gated channel subfamily A member 1;Voltage-gated potassium channel subunit beta-2	KCNA2;KCNA1;KCNAB2	None;None;KCNA2B KCNK2
7394	CENP-H-I complex	Human	None	HeLa cells	Q13352;Q6IPU0;Q71F23;Q7L2Z9;Q8N0S6;Q92674;Q96H22;Q9BS16;Q9BU64;Q9H3R5;Q9NSP4	23421;401541;79682;55166;91687;2491;55839;64105;79172;64946;79019	MI:0004-affinity chromatography technology	GO:0051276;GO:0006334;GO:0007059;GO:0051382;GO:0007049	chromosome organization;nucleosome assembly;chromosome segregation;kinetochore assembly;cell cycle	42.10.03;10.03.04.05;10.03.04.01;10.03	organization of chromosome structure;chromosome segregation/division;centromere/kinetochore complex maturation;cell cycle	16622420	The CENP-H-I complex is required for the incorporation of newly synthesized CENP-A into centromeres.CENP-L and CENP-M were only isolated in chicken cells, although both proteins were identified in proteomic analysis of human CENP-A nucleosomes, suggesting that they function at human centromeres.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Centromere protein R;Centromere protein P;Centromere protein U;Centromere protein Q;Centromere protein L;Centromere protein I;Centromere protein N;Centromere protein K;Centromere protein O;Centromere protein H;Centromere protein M	ITGB3BP;CENPP;CENPU;CENPQ;CENPL;CENPI;CENPN;CENPK;CENPO;CENPH;CENPM	CENPR NRIF3;None;ICEN24 KLIP1 MLF1IP PBIP1;C6orf139;C1orf155 ICEN33;FSHPRH1 ICEN19 LRPR1;C16orf60 ICEN32;ICEN37;ICEN36 MCM21R;ICEN35;C22orf18 ICEN39 PANE1
7395	ADAM22-LGI1 complex	Human	None	HEK293T cells; in vitro	O95970;Q9P0K1	9211;53616	MI:0019-coimmunoprecipitation;MI:0096-pull down;MI:0114-x-ray crystallography	GO:0035249	synaptic transmission, glutamatergic	None	None	29670100	Epilepsy-related ligand-receptor complex, LGI1-ADAM22, regulates synaptic transmission and has emerged as a determinant of brain excitability, as their mutations and acquired LGI1 autoantibodies cause epileptic disorders in human. The crystal structure of human LGI1-ADAM22 complex, revealing a 2:2 heterotetrameric assembly, is reported. The hydrophobic pocket of the C-terminal epitempin-repeat (EPTP) domain of LGI1 binds to the metalloprotease-like domain of ADAM22. The N-terminal leucine-rich repeat and EPTP domains of LGI1 mediate the intermolecular LGI1-LGI1 interaction. The LGI1-ADAM22ligand\u2013receptor interaction plays an essential role in AMPA type glutamate receptor-mediated synaptic transmission via PSD-95.	Mutations of LGI1 cause autosomal dominant lateral temporal lobe epilepsy (ADLTE; also known as autosomal dominant partial epilepsy with auditory features (ADPEAF)).	None	Homo sapiens (Human);Homo sapiens (Human)	Leucine-rich glioma-inactivated protein 1;Disintegrin and metalloproteinase domain-containing protein 22	LGI1;ADAM22	EPT;MDC2
7403	SREBP-1a-PKM2 complex	Human	None	Hepatocellular carcinoma cells, HEK293T cells	P14618;P36956	5315;6720	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0046890;GO:0008283	regulation of lipid biosynthetic process;cell population proliferation	None	None	29514980	In mammalian cells, there are three SREBP isoforms (SREBP-1a, -1c, and -2) encoded by two different genes, Srebf1 and Srebf2 . Two distinct promoters generate SREBP-1a and SREBP-1c isoforms from the Srebf1 gene . Srebf1a is expressed at higher levels in cancer cells as compared with normal tissues, whereas Srebf1c is the predominant product of Srebf1 in normal tissues. PKM2 directly interacts with the nuclear form of SREBP-1a, but not with SREBP-1c, and SREBP-2  isoforms in hepatocellular carcinoma cells (PMID:29514980).	OMIM:114550 Hepatocellular carcinoma (PMID:29514980)	None	Homo sapiens (Human);Homo sapiens (Human)	Pyruvate kinase PKM;Sterol regulatory element-binding protein 1	PKM;SREBF1	OIP3 PK2 PK3 PKM2;BHLHD1, SREBP1
7405	TMEM173-TBK1 complex	Human	None	HEK294T cells	Q86WV6;Q9UHD2	340061;29110	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0003260	cardioblast migration	None	None	29547894	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Stimulator of interferon genes protein;Serine/threonine-protein kinase TBK1	STING1;TBK1	ERIS MITA STING TMEM173;NAK
7406	AKT1-APPL1-HDAC3 complex	Human	None	C4-2 cells	O15379;P31749;Q9UKG1	8841;207;26060	MI:0096-pull down	None	None	None	None	29523594	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone deacetylase 3;RAC-alpha serine/threonine-protein kinase;DCC-interacting protein 13-alpha	HDAC3;AKT1;APPL1	None;PKB RAC;APPL DIP13A KIAA1428
7407	TOP3B-c complex	Human	None	HeLa cells	O95985;Q9H7E2	8940;81550	MI:0019-coimmunoprecipitation;MI:0096-pull down	None	None	None	None	29471495	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	DNA topoisomerase 3-beta-1;Tudor domain-containing protein 3	TOP3B;TDRD3	TOP3B1;None
7408	ARRB1-ARHGEF18-ENAH complex, induce by EDN-1	Human	None	HEY cells	P49407;Q6ZSZ5;Q8N8S7	408;23370;55740	MI:0019-coimmunoprecipitation	None	None	None	None	29439204	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Beta-arrestin-1;Rho guanine nucleotide exchange factor 18;Protein enabled homolog	ARRB1;ARHGEF18;ENAH	ARR1;KIAA0521;MENA
7410	CAPG-PRMT5 complex	Human	None	HEK293T cells	O14744;P40121	10419;822	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0006355	regulation of DNA-templated transcription	11.02.03.04	transcriptional control	29721098	CAPG suppressed PRMT5 binding to the STC-1 gene promoter, which decreased PRMT5-dependent histone H4R3 methylation and subsequent decrease of CpG DNA methylation, resulting in enhanced STC-1 transcription . Therefore, CAPG and PRMT5 expression may be a promising biomarker to determine prognosis in breast cancer (PMID:29721098).	OMIM:114480 Breast cancer. PRMT5 interacts with CAPG and predicts a favorable prognosis in breast cancer (PMID:29721098).	None	Homo sapiens (Human);Homo sapiens (Human)	Protein arginine N-methyltransferase 5;Macrophage-capping protein	PRMT5;CAPG	HRMT1L5 IBP72 JBP1 SKB1;AFCP MCP
7413	CENPA-histone H4-HJURP complex	Human	CENPA-HIST1H4A-HJURP complex	None	P49450;P62805;Q8NCD3	1058;None;55355	MI:0071-molecular sieving;MI:0114-x-ray crystallography	GO:0006325;GO:0006334	chromatin organization;nucleosome assembly	None	None	21478274	HJURP binds to the CENPA-histone H4 heterodimer and prevents tetramer formation of CENPA and histone H4.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone H3-like centromeric protein A;Histone H4;Holliday junction recognition protein	CENPA;H4C1;HJURP	None;H4/A H4FA HIST1H4A;FAKTS FLEG1 URLC9
7416	GJB2-PTK2-NANOG complex	Human	CX26-FAK-NANOG complex	MDA-MB-231 cells	P29033;Q05397;Q9H9S0	2706;5747;79923	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:2000035	regulation of stem cell division	None	None	29422613	Cx26 promotes cancer stem cells (CSC) self-renewal by forming a signaling complex with the pluripotency transcription factor NANOG and focal adhesion kinase (FAK), resulting in NANOG stabilization and FAK activation. The unique signaling complex may be amenable for targeting and compromising  triple-negative breast cancer CSC maintenance (PMID:29422613).	OMIM:114480 Breast cancer  (PMID:29422613).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Gap junction beta-2 protein;Focal adhesion kinase 1;Homeobox protein NANOG	GJB2;PTK2;NANOG	None;FAK, FAK1;None
7417	CFTR-GOPC-STX6 complex	Human	CFTR-CAL-STX6 complex	HEK293 cells	O43752;P13569;Q9HD26	10228;1080;57120	MI:0019-coimmunoprecipitation	GO:1902822	regulation of late endosome to lysosome transport	None	None	20130090	The functional requirement of CAL suggested a model that the CAL/STX6/CFTR complex directs CFTR trafficking to the lysosome (PMID:20130090).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Syntaxin-6;Cystic fibrosis transmembrane conductance regulator;Golgi-associated PDZ and coiled-coil motif-containing protein	STX6;CFTR;GOPC	None;ABCC7;CAL FIG
7418	HK1-VDAC1 complex	Human	None	SCC9 cells	P19367;P21796	3098;7416	MI:0071-molecular sieving	GO:0033554	cellular response to stress	None	None	22304920	Genotoxic stress enables ATF2 nuclear export and localization at the mitochondria, where it perturbs the HK1-VDAC1 complex.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Hexokinase-1;Voltage-dependent anion-selective channel protein 1	HK1;VDAC1	None;VDAC
7420	TP53-TSPY1-USP7 complex	Human	TSPY1-USP7-p53 complex	HEK293 cells	P04637;Q01534;Q93009	7157;100289087;7874	MI:0019-coimmunoprecipitation	GO:0007283	spermatogenesis	None	None	29748603	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cellular tumor antigen p53;Testis-specific Y-encoded protein 1;Ubiquitin carboxyl-terminal hydrolase 7	TP53;TSPY1;USP7	P53;TSPY;HAUSP
7421	TSPY1-TSPYL5-USP7 complex	Human	None	A549 cells	Q01534;Q86VY4;Q93009	100289087;85453;7874	MI:0019-coimmunoprecipitation	GO:0051726;GO:0042981	regulation of cell cycle;regulation of apoptotic process	10.03.01	mitotic cell cycle and cell cycle control	29748603	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Testis-specific Y-encoded protein 1;Testis-specific Y-encoded-like protein 5;Ubiquitin carboxyl-terminal hydrolase 7	TSPY1;TSPYL5;USP7	TSPY;KIAA1750;HAUSP
7422	PPP1R13L-CEP55 complex	Human	None	HeLa cells	Q53EZ4;Q8WUF5	55165;10848	MI:0019-coimmunoprecipitation	GO:0000910	cytokinesis	10.03.03	cytokinesis (cell division) /septum formation and hydrolysis	29743530	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Centrosomal protein of 55 kDa;RelA-associated inhibitor	CEP55;PPP1R13L	C10orf3 URCC6;IASPP NKIP1 PPP1R13BL RAI
7423	PPP1CA-PPP1R13L complex	Human	iASPP\u2013PP1 complex	None	P62136;Q8WUF5	5499;10848	MI:0019-coimmunoprecipitation	GO:0016311	dephosphorylation	None	None	21998301	iASPP\u2013PP1 complex dephosphorylates mitotic CEP55 at Ser436(PMID:29743530).	None	None	Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein phosphatase PP1-alpha catalytic subunit;RelA-associated inhibitor	PPP1CA;PPP1R13L	PPP1A;IASPP NKIP1 PPP1R13BL RAI
7424	ISLR2-ROCK1 complex	Human	LINX-ROCK1 complex	293FT cells; neuroblastoma cells	Q13464;Q6UXK2	6093;57611	MI:0019-coimmunoprecipitation	None	None	None	None	29739947	Linx/Rho-kinase complex could be at least relevant to the regulation of cell body size and neurite extension, which may have a role in the development of brain architecture and neuronal connectivity (PMID:29739947).	None	None	Homo sapiens (Human);Homo sapiens (Human)	Rho-associated protein kinase 1;Immunoglobulin superfamily containing leucine-rich repeat protein 2	ROCK1;ISLR2	None;KIAA1465 LINX
7425	KIAA1468-OSBP-RAB11A complex	Human	RAB11A-RELCH-OSBP complex	None	P22059;P62491;Q9P260	5007;8766;57614	MI:0019-coimmunoprecipitation	GO:0032371	regulation of sterol transport	None	None	29514919	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Oxysterol-binding protein 1;Ras-related protein Rab-11A;RAB11-binding protein RELCH	OSBP;RAB11A;RELCH	OSBP1;RAB11;KIAA1468
7427	ATF2-HK1-VDAC1 complex	Human	None	SCC9 cells	P15336;P19367;P21796	1386;3098;7416	MI:0019-coimmunoprecipitation;MI:0071-molecular sieving	GO:0006355;GO:0033554	regulation of DNA-templated transcription;cellular response to stress	11.02.03.04	transcriptional control	22304920	Following genotoxic stress, cytosolic ATF2 is transportet into mitochondria where it binds to HK1-VDAC1 complex resulting in disruption of the complex. This sensitizes cells to stress and impaires mitochondrial membrane integrity.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cyclic AMP-dependent transcription factor ATF-2;Hexokinase-1;Voltage-dependent anion-selective channel protein 1	ATF2;HK1;VDAC1	CREB2 CREBP1;None;VDAC
7428	mtRNase P	Human	Ribonuclease P; mitochondrial RNase P; HSD17B10-KIAA0391-TRMT10C complex	293 cells	O15091;Q7L0Y3;Q99714	9692;54931;None	MI:0007-anti tag coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0030678	mitochondrial ribonuclease P complex	None	None	18984158	tRNAs are synthesized as immature precursors. Extra nucleotides at their 5' termini are removed by an endonuclease called ribonuclease P (RNase P).	None	Human mtRNase P is composed of three proteins but no RNA.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mitochondrial ribonuclease P catalytic subunit;tRNA methyltransferase 10 homolog C;3-hydroxyacyl-CoA dehydrogenase type-2	PRORP;TRMT10C;HSD17B10	KIAA0391 MRPP3;MRPP1 RG9MTD1;ERAB HADH2 MRPP2 SCHAD SDR5C1 XH98G2
7429	HSD17B10-TRMT10C complex	Human	MRPP1-MRPP2 complex	None	Q7L0Y3;Q99714	54931;None	MI:0071-molecular sieving	GO:0008033;GO:0098798;GO:0000049	tRNA processing;mitochondrial protein-containing complex;tRNA binding	11.04.02	tRNA processing	29040705	The MRPP1-MRPP2 complex is not only responsible for mitochondrial RNase P-based 5?-leader removal, but  it also remains attached to the tRNA substrate to enable further downstream processing steps including 3? -tail removal by ELAC2 and 3?-CCA addition by the CCA adding enzyme.	None	None	Homo sapiens (Human);Homo sapiens (Human)	tRNA methyltransferase 10 homolog C;3-hydroxyacyl-CoA dehydrogenase type-2	TRMT10C;HSD17B10	MRPP1 RG9MTD1;ERAB HADH2 MRPP2 SCHAD SDR5C1 XH98G2
7430	FLCN-FNIP2 complex	Human	None	HEK-293T cells	Q8NFG4;Q9P278	201163;57600	MI:0019-coimmunoprecipitation	GO:0031929	TOR signaling	None	None	24095279	FLCN-FNIP2 is a Rag-interacting complex and is necessary for mTORC1 activation by amino acids.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Folliculin;Folliculin-interacting protein 2	FLCN;FNIP2	BHD;FNIPL KIAA1450 MAPO1
7437	KAT2B-KIF11-MYSM1 complex	Human	2A-DUB complex	HEK293T cells	P52732;Q5VVJ2;Q92831	3832;114803;8850	MI:0007-anti tag coimmunoprecipitation	GO:0035522;GO:0016573;GO:0006352;GO:0006354	monoubiquitinated histone H2A deubiquitination;histone acetylation;DNA-templated transcription initiation;DNA-templated transcription elongation	11.02.03.01.01;11.02.03.01.04	transcription initiation;transcription elongation	17707232	ChIP data indicate that the 2A-DUB complex, with the consequent alteration of uH2A status, participates in the initiation and likely the elongation steps of androgen/AR-induced gene activation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Kinesin-like protein KIF11;Deubiquitinase MYSM1;Histone acetyltransferase KAT2B	KIF11;MYSM1;KAT2B	EG5 KNSL1 TRIP5;KIAA1915;PCAF
7439	ECT2-KIF23-RACGAP1 complex	Human	None	HeLa cells	Q02241;Q9H0H5;Q9H8V3	9493;29127;1894	MI:0019-coimmunoprecipitation	GO:0000915;GO:0051233	actomyosin contractile ring assembly;spindle midzone	None	None	16236794	Active Rho is required for contractile ring formation and ECT2-KIF23-RACGAP1 complex regulates translocation of Rho to the equatorial region.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Kinesin-like protein KIF23;Rac GTPase-activating protein 1;Protein ECT2	KIF23;RACGAP1;ECT2	KNSL5 MKLP1;KIAA1478 MGCRACGAP;None
7440	KIF23-RACGAP1 complex	Human	Centralspindlin	HeLa cells	Q02241;Q9H0H5	9493;29127	MI:0019-coimmunoprecipitation	GO:0051233;GO:0001578;GO:0000910	spindle midzone;microtubule bundle formation;cytokinesis	10.03.03	cytokinesis (cell division) /septum formation and hydrolysis	11782313	Centralspindlin, but not its individual components, strongly promotes microtubule bundling in vitro.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Kinesin-like protein KIF23;Rac GTPase-activating protein 1	KIF23;RACGAP1	KNSL5 MKLP1;KIAA1478 MGCRACGAP
7441	HOOK1-SHP2 complex	Human	SHP2-HOOK1 complex	HEK293T cells	Q06124;Q9UJC3	5781;51361	MI:0019-coimmunoprecipitation	GO:0010719	negative regulation of epithelial to mesenchymal transition	None	None	25331952	SHP2-Hook1 complex may play an important role in tumor metastases by regulating epithelial-mesenchymal transition in cancer cells.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Tyrosine-protein phosphatase non-receptor type 11;Protein Hook homolog 1	PTPN11;HOOK1	PTP2C SHPTP2;None
7442	HOOK2-PCM1-RAB8A complex	Human	None	embryonic kidney cell lysates	P61006;Q15154;Q96ED9	4218;5108;29911	MI:0019-coimmunoprecipitation	GO:0071539;GO:0060271	protein localization to centrosome;cilium assembly	None	None	21998199	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Ras-related protein Rab-8A;Pericentriolar material 1 protein;Protein Hook homolog 2	RAB8A;PCM1;HOOK2	MEL RAB8;None;None
7443	Exosome	Human	None	HeLa cells	Q01780;Q06265;Q13868;Q15024;Q5RKV6;Q8TF46;Q96B26;Q99547;Q9NPD3;Q9NQT4;Q9NQT5;Q9Y3B2	5394;5393;23404;23016;118460;115752;11340;10200;54512;56915;51010;51013	MI:0004-affinity chromatography technology;MI:0019-coimmunoprecipitation	GO:0004532;GO:0006401;GO:0005737	exoribonuclease activity;RNA catabolic process;cytoplasm	01.03.16.01;70.03	RNA degradation;cytoplasm	20531389	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Exosome component 10;Exosome complex component RRP45;Exosome complex component RRP4;Exosome complex component RRP42;Exosome complex component MTR3;DIS3-like exonuclease 1;Exosome complex component RRP43;M-phase phosphoprotein 6;Exosome complex component RRP41;Exosome complex component RRP46;Exosome complex component RRP40;Exosome complex component CSL4	EXOSC10;EXOSC9;EXOSC2;EXOSC7;EXOSC6;DIS3L;EXOSC8;MPHOSPH6;EXOSC4;EXOSC5;EXOSC3;EXOSC1	PMSCL PMSCL2 RRP6;PMSCL1;RRP4;KIAA0116 RRP42;MTR3;DIS3L1,KIAA1955;OIP2 RRP43;MPP6;RRP41 SKI6;CML28 RRP46;RRP40;CSL4
7444	HOOK2-PAR3-Par6alpha-PKCiota complex	Human	HOOK2-PAR3-PAR6alpha-aPKC complex	HEK cells, MCF7 cells	P41743;Q8TEW0;Q96ED9;Q9NPB6	5584;56288;29911;50855	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0010631;GO:0051642	epithelial cell migration;centrosome localization	None	None	27624926	Hook2 acts as an adaptor to recruit the PAR complex to the centrosome.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein kinase C iota type;Partitioning defective 3 homolog;Protein Hook homolog 2;Partitioning defective 6 homolog alpha	PRKCI;PARD3;HOOK2;PARD6A	DXS1179E;PAR3 PAR3A;None;PAR6A
7445	HOOK2-KCL3-LRGUK1-RIMBP3 complex	Human	LRGUK1-HOOK2-RIMBP3-KCL3 complex	HEK293T cells	Q6P597;Q96ED9;Q96M69;Q9UFD9	147700;29911;136332;85376	MI:0019-coimmunoprecipitation	GO:1905198;GO:0007286	manchette assembly;spermatid development	None	None	28003339	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Kinesin light chain 3;Protein Hook homolog 2;Leucine-rich repeat and guanylate kinase domain-containing protein;RIMS-binding protein 3A	KLC3;HOOK2;LRGUK;RIMBP3	KLC2 KLC2L;None;None;KIAA1666,RIMBP3A
7459	Glycine receptor (GLRA11, GLRB)	Human	None	None	P23415;P48167	2741;2743	MI:0051-fluorescence technology	GO:0016934	extracellularly glycine-gated chloride channel activity	None	None	22973015	The glycine receptor chloride channel (GlyR), a member of the pentameric Cys-loop ion channel receptor family, mediates inhibitory neurotransmission in the spinal cord, brainstem and retina. They are also found presynaptically, where they modulate neurotransmitter release (PMID:18721822).	None	Functional GlyRs are formed from a total of five subunits (alpha1-alpha4, beta). Although alpha subunits efficiently form homomeric GlyRs in recombinant expression systems, homomeric alpha1, alpha3 and alpha4 GlyRs are weakly expressed in adult neurons. In contrast, alpha2 homomeric GlyRs are abundantly expressed in embryonic neurons, although their numbers decline sharply by adulthood. Numerous lines of biochemical, biophysical, pharmacological and genetic evidence suggest the majority of glycinergic neurotransmission in adults is mediated by heteromeric alpha1beta GlyRs. Immunocytochemical co-localisation experiments suggest the presence of alpha2beta, alpha3beta and alpha4beta GlyRs at synapses in the adult mouse retina. Immunocytochemical and electrophysiological evidence also implicates alpha3beta GlyRs as important mediators of glycinergic inhibitory neurotransmission in nociceptive sensory neuronal circuits in peripheral laminae of the spinal cord dorsal horn (PMID:18721822).	Homo sapiens (Human);Homo sapiens (Human)	Glycine receptor subunit alpha-1;Glycine receptor subunit beta	GLRA1;GLRB	None;None
7462	GABA-A receptor (GABRA1, GABRB2, GABRD)	Human	None	None	O14764;P14867;P47870	2563;2554;2561	MI:0055-fluorescent resonance energy transfer	GO:0004890	GABA-A receptor activity	None	None	27493204	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Gamma-aminobutyric acid receptor subunit delta;Gamma-aminobutyric acid receptor subunit alpha-1;Gamma-aminobutyric acid receptor subunit beta-2	GABRD;GABRA1;GABRB2	None;None;None
7476	AP1B1-AP1G2-AP1M1-AP1S1 complex	Human	AP-1 complex (sigma 1A, mu1, beta1, gamma2)	M1 human fibroblasts	O75843;P61966;Q10567;Q9BXS5	8906;1174;162;8907	MI:0019-coimmunoprecipitation;MI:0808-comigration in sds page	GO:0016192	vesicle-mediated transport	20.09.07	vesicular transport (Golgi network, etc.)	21097499	The clathrin-associated, heterotetrameric adaptor protein (AP) complexes, AP-1, AP-2, and AP-3, recognize signals in the cytosolic domains of transmembrane proteins, leading to their sorting to endosomes, lysosomes, lysosome-related organelles, and/or the basolateral membrane of polarized epithelial cells.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	AP-1 complex subunit gamma-like 2;AP-1 complex subunit sigma-1A;AP-1 complex subunit beta-1;AP-1 complex subunit mu-1	AP1G2;AP1S1;AP1B1;AP1M1	None;AP19 CLAPS1;ADTB1 BAM22 CLAPB2;CLTNM
7477	MIA2-MIA3-PREB complex	Human	TANGO1L-cTAGE5-SEC12 complex	HeLa cells	Q5JRA6-1;Q96PC5;Q9HCU5	375056;4253;10113	MI:0019-coimmunoprecipitation	GO:0006888;GO:0016192	endoplasmic reticulum to Golgi vesicle-mediated transport;vesicle-mediated transport	20.09.07.03;20.09.07	ER to Golgi transport;vesicular transport (Golgi network, etc.)	27413011	TANGO1 (L) is an integral membrane protein that binds to collagen and the coatomer of vesicles and is necessary for collagen secretion from the ER. The short isoform of TANGO1 (TANGO1S), lacking the collagen-binding domain, was found that it was independently required for collagen export from the ER. Each of the TANGO1 isoforms forms a stable protein complex with factors involved in collagen secretion: TANGO1L/cTAGE5/Sec12 (900 kDa) and TANGO1S/cTAGE5/Sec12 (700 kDa). TANGO1S and TANGO1L seemed to be interchangeable in exporting collagen from the ER. It was suggested that mammalian ER exit sites possess two different-sized membrane-bound macromolecular complexes that specifically function in large-cargo export from the ER (PMID:27413011).	None	O15320 was replaced by UniProtKB. New ID is Q96PC5.TANGO1L is a splice variant of MIA3 (Q5JRA6-1).	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Isoform 1 of Transport and Golgi organization protein 1 homolog;Melanoma inhibitory activity protein 2;Prolactin regulatory element-binding protein	MIA3;MIA2;PREB	KIAA0268 TANGO;CTAGE5 MEA11 MEA6 MGEA11 MGEA6;SEC12
7478	MIA2-MIA3-PREB complex	Human	TANGO1S-cTAGE5-SEC12 complex	HeLa cells	Q5JRA6-4;Q96PC5;Q9HCU5	375056;4253;10113	MI:0019-coimmunoprecipitation	GO:0006888;GO:0016192	endoplasmic reticulum to Golgi vesicle-mediated transport;vesicle-mediated transport	20.09.07.03;20.09.07	ER to Golgi transport;vesicular transport (Golgi network, etc.)	27413011	TANGO1 (L) is an integral membrane protein that binds to collagen and the coatomer of vesicles and is necessary for collagen secretion from the ER. The short isoform of TANGO1 (TANGO1S), lacking the collagen-binding domain, was found that it was independently required for collagen export from the ER. Each of the TANGO1 isoforms forms a stable protein complex with factors involved in collagen secretion: TANGO1L/cTAGE5/Sec12 (900 kDa) and TANGO1S/cTAGE5/Sec12 (700 kDa). TANGO1S and TANGO1L seemed to be interchangeable in exporting collagen from the ER. It was suggested that mammalian ER exit sites possess two different-sized membrane-bound macromolecular complexes that specifically function in large-cargo export from the ER (PMID:27413011).	None	TANGO1S is the short splice variant of MIA3 (TANGOS) (Q5JRA6-4).	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Isoform 4 of Transport and Golgi organization protein 1 homolog;Melanoma inhibitory activity protein 2;Prolactin regulatory element-binding protein	MIA3;MIA2;PREB	KIAA0268 TANGO;CTAGE5 MEA11 MEA6 MGEA11 MGEA6;SEC12
7479	Astrin-kinastrin complex	Human	None	HeLa cells	P53350;P63167;Q562F6;Q96R06;Q9Y448	5347;8655;151246;10615;90417	MI:0019-coimmunoprecipitation	GO:0051988	regulation of attachment of spindle microtubules to kinetochore	None	None	21402792	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein kinase PLK1;Dynein light chain 1, cytoplasmic;Shugoshin 2;Sperm-associated antigen 5;Small kinetochore-associated protein	PLK1;DYNLL1;SGO2;SPAG5;KNSTRN	PLK;DLC1 DNCL1 DNCLC1 HDLC1;SGOL2;None;C15orf23 SKAP TRAF4AF1
7480	HDAC3-H1.3-SMRT-N-Cor complex	Human	HDAC3-HIST1H1D-NCOR1-NCOR2 complex	HeLa S3 cells	O15379;O75376;P16402;Q9Y618	8841;9611;3007;9612	MI:0096-pull down	None	None	None	None	26663086	HDAC3-H1.3 complex containing silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) and nuclear receptor corepressor 1 (N-CoR) was accumulated in synchronized HeLa cells in late G2 phase and mitosis (PMID:26663086).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone deacetylase 3;Nuclear receptor corepressor 1;Histone H1.3;Nuclear receptor corepressor 2	HDAC3;NCOR1;H1-3;NCOR2	None;KIAA1047;H1F3 HIST1H1D;CTG26
7482	LAP1-TOR1A complex	Human	None	None	O14656;Q5JTV8	1861;26092	MI:0019-coimmunoprecipitation	GO:0043462	regulation of ATP-dependent activity	None	None	15767459	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Torsin-1A;Torsin-1A-interacting protein 1	TOR1A;TOR1AIP1	DQ2 DYT1 TA TORA;LAP1
7483	ARF1-ARFIP2-ARL1-PKD2 complex	Human	None	HEK293T cell	P40616;P53365;P84077;Q13563	400;23647;375;5311	MI:0019-coimmunoprecipitation	GO:0051223;GO:0016192	regulation of protein transport;vesicle-mediated transport	20.09.07	vesicular transport (Golgi network, etc.)	26507660	At the TGN (trans-Golgi network), where PKD2 interacts with active ARF1, PKD2, and ARL1 are required for the assembly of a complex comprising of ARF1 and Arfaptin2 leading to secretion of matrix metalloproteinase-2 and -7. In conclusion, the data indicate that PKD2 is a core factor in the formation of this multiprotein complex at the TGN that controls constitutive secretion of matrix metalloproteinase cargo (PMID:26507660).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	ADP-ribosylation factor-like protein 1;Arfaptin-2;ADP-ribosylation factor 1;Polycystin-2	ARL1;ARFIP2;ARF1;PKD2	None;POR1;None;TRPP2
7485	HAS1-HAS2 complex	Human	None	None	Q92819;Q92839	3037;3036	MI:0400-affinity technology	GO:0050501	hyaluronan synthase activity	None	None	25795779	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Hyaluronan synthase 2;Hyaluronan synthase 1	HAS2;HAS1	None;HAS
7486	HAS2-HAS3	Human	None	None	O00219;Q92819	3038;3037	MI:0400-affinity technology	GO:0050501	hyaluronan synthase activity	None	None	25795779	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Hyaluronan synthase 3;Hyaluronan synthase 2	HAS3;HAS2	None;None
7487	DTNBP1(1A)-HDAC3 complex	Human	None	Meuroblastoma cells	O15379;Q96EV8-1	8841;84062	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0042325	regulation of phosphorylation	None	None	25196196	None	None	DTNBP1(1A) is a splice variant of DTNBP1.Dysbindin-1 formed a protein complex with HDAC3 in human neuroblastoma cells and in mouse brain. The interaction between dysbindin-1 and HDAC3 occurred in an isoform-specific manner: HDAC3 coupled with dysbindin-1A and -1B, but not -1C (PMID:25196196).	Homo sapiens (Human);Homo sapiens (Human)	Histone deacetylase 3;Isoform 1 of Dysbindin	HDAC3;DTNBP1	None;BLOC1S8
7488	DTNBP1(1B)-HDAC3 complex	Human	None	Neuroblastoma cells	O15379;Q96EV8-3	8841;84062	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0042325	regulation of phosphorylation	None	None	25196196	None	None	DTNBP1(1B) is a splice variant of DTNBP1.Dysbindin-1 formed a protein complex with HDAC3 in human neuroblastoma cells and in mouse brain. The interaction between dysbindin-1 and HDAC3 occurred in an isoform-specific manner: HDAC3 coupled with dysbindin-1A and -1B, but not -1C (PMID:25196196).	Homo sapiens (Human);Homo sapiens (Human)	Histone deacetylase 3;Isoform 3 of Dysbindin	HDAC3;DTNBP1	None;BLOC1S8
7489	EglN2-NRF1-PGC1alpha complex	Human	None	MCF-7 cells	Q14494;Q96KS0;Q9UBK2	4779;112398;10891	MI:0019-coimmunoprecipitation	GO:0003713	transcription coactivator activity	None	None	26492917	By forming an activator complex with PGC1alpha and NRF1 on chromatin, EglN2 promotes the transcription of ferridoxin reductase (FDXR) and maintains mitochondrial function. In addition, FDXR, as one of effectors for EglN2, contributes to breast tumorigenesis in vitro and in vivo. These findings suggest that EglN2 regulates mitochondrial function in ERalpha-positive breast cancer (PMID:26492917).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Endoplasmic reticulum membrane sensor NFE2L1;Prolyl hydroxylase EGLN2;Peroxisome proliferator-activated receptor gamma coactivator 1-alpha	NFE2L1;EGLN2;PPARGC1A	HBZ17,NRF1,TCF11;EIT6;LEM6 PGC1 PGC1A PPARGC1
7490	VEGF-A165-VEGFR2 complex	Human	None	None	P15692-4;P35968	7422;3791	MI:0004-affinity chromatography technology	GO:0045807	positive regulation of endocytosis	None	None	27044325	VEGF-A binding to VEGFR2 triggers distinct patterns of ubiquitylation, proteolysis and clearance within the endosome-lysosome system. VEGF-A isoforms had distinct properties in regulating VEGFR2 endocytosis at the plasma membrane, it was predicted that VEGF-A-stimulated VEGFR2 degradation was isoform-specific. It was confirmed that this was indeed true: VEGF-A121 showed negligible effects on VEGFR2 degradation; however, VEGF-A165 or VEGF-A145 showed a similar 30% reduction in total VEGFR2 levels after 120 min (PMID:7044325).	None	VEGF-A165 is a splice variant of VEGFA.	Homo sapiens (Human);Homo sapiens (Human)	Isoform VEGF165 of Vascular endothelial growth factor A;Vascular endothelial growth factor receptor 2	VEGFA;KDR	VEGF;FLK1 VEGFR2
7491	VEGF-A145-VEGFR2 complex	Human	None	None	P15692-6;P35968	7422;3791	MI:0004-affinity chromatography technology	None	None	None	None	27044325	VEGF-A binding to VEGFR2 triggers distinct patterns of ubiquitylation, proteolysis and clearance within the endosome-lysosome system. VEGF-A isoforms had distinct properties in regulating VEGFR2 endocytosis at the plasma membrane, it was predicted that VEGF-A-stimulated VEGFR2 degradation was isoform-specific. It was confirmed that this was indeed true: VEGF-A121 showed negligible effects on VEGFR2 degradation; however, VEGF-A165 or VEGF-A145 showed a similar 30% reduction in total VEGFR2 levels after 120min. VEGF-A isoforms promoted differential patterns of VEGFR2 ubiquitylation, proteolysis and terminal degradation (PMID:7044325).	None	VEGF-A145 is a splice variant of VEGFA.	Homo sapiens (Human);Homo sapiens (Human)	Isoform VEGF145 of Vascular endothelial growth factor A;Vascular endothelial growth factor receptor 2	VEGFA;KDR	VEGF;FLK1 VEGFR2
7493	sGNAI2-DRD2 receptor complex	Human	sGi2-D2-receptor complex	BHK cells	P04899-4;P14416	2771;1813	MI:0004-affinity chromatography technology	GO:0060159	regulation of dopamine receptor signaling pathway	None	None	17550964	sGi2 protein participates in the formation of an intracellular D2 receptor pool by specific protein-protein interaction and in the regulation of the density of these receptors at the cell membrane (PMID:17550964 )	None	sGNAI2 (sGalphai2,sGi2) is a splice variant of GNAI2.	Homo sapiens (Human);Homo sapiens (Human)	Isoform sGi2 of Guanine nucleotide-binding protein G(i) subunit alpha-2;D(2) dopamine receptor	GNAI2;DRD2	GNAI2B;None
7495	KDR-VEGF-A121 complex	Human	VEGF121-VEGFR2 complex	None	P15692-9;P35968	7422;3791	MI:0114-x-ray crystallography	None	None	None	None	22207738	None	None	VEGF-A121 is a splice variant of VEGFA.	Homo sapiens (Human);Homo sapiens (Human)	Isoform VEGF121 of Vascular endothelial growth factor A;Vascular endothelial growth factor receptor 2	VEGFA;KDR	VEGF;FLK1 VEGFR2
7496	NRP2-VEGF-A165 complex	Human	None	None	O60462;P15692-4	8828;7422	MI:0030-cross-linking study	None	None	None	None	11278319	None	None	VEGF-A165 is a splice variant of VEGFA.	Homo sapiens (Human);Homo sapiens (Human)	Neuropilin-2;Isoform VEGF165 of Vascular endothelial growth factor A	NRP2;VEGFA	VEGF165R2;VEGF
7497	FLT1-VEGF-A121 complex	Human	VEGFR1-VEGF-A121 complex	None	P15692-9;P17948	7422;2321	MI:0114-x-ray crystallography	GO:0001525;GO:0045602	angiogenesis;negative regulation of endothelial cell differentiation	41.05.16	angiogenesis	22207738	The soluble FLT-1 receptor differentiated VEGF isoforms (165, 165/110, 110, and 121) with apparent affinities of 10, 30, 120, and 200 pM, respectively. Endothelial cell mitogenic potencies of VEGF110 and VEGF121 were decreased more than 100-fold compared to that of VEGF165 (PMID:8631822). All VEGF-A isoforms (VEGF121, VEGF145, VEGF165, VEGF189, VEGF206) except VEGF121 also bind to heparan sulfate or to heparin, a highly sulfated form of heparan sulfate . Heparin augments the interaction of VEGF165 with VEGFR2 and binds to VEGFR1 (PMID:20974861).	None	VEGF-A121 is a splice variant of VEGFA.	Homo sapiens (Human);Homo sapiens (Human)	Isoform VEGF121 of Vascular endothelial growth factor A;Vascular endothelial growth factor receptor 1	VEGFA;FLT1	VEGF;FLT FRT VEGFR1
7498	NRP1-VEGF-A145 complex	Human	None	PAE cells	O14786;P15692-6	8829;7422	MI:0019-coimmunoprecipitation	None	None	None	None	18559514	VEGF-A145 showed competition for binding to NRP1. (PMID:18559514).VEGF-A145 lacks the NRP1-binding exon 7, but exon 8 in the vegf-a gene has also been implicated in binding to NRP1 (PMID:16513643)	None	VEGF-A145 is a splice variant of VEGFA.	Homo sapiens (Human);Homo sapiens (Human)	Neuropilin-1;Isoform VEGF145 of Vascular endothelial growth factor A	NRP1;VEGFA	NRP, VEGF165R;VEGF
7499	VEGFA-VEGF-B167 complex	Human	None	293EBNA cells	P15692;P49765-2	7422;7423	MI:0019-coimmunoprecipitation	None	None	None	None	8637916	The ability of VEGF-B to heterodimerize with VEGF is consistent with the conservation of the eight cysteine residues involved in inter- and intramolecular disulfide bonding. The coexpression of VEGF-B and VEGF in many tissues suggests that VEGF-B167-VEGF heterodimers occur naturally. The formation and cell association of such heterodimers may affect the formation of VEGF homodimers and thus indirectly control release and bioavailability of VEGF (PMID:8637916).	None	VEGFB-167 is a splice variant of VEGFB.	Homo sapiens (Human);Homo sapiens (Human)	Vascular endothelial growth factor A;Isoform VEGF-B167 of Vascular endothelial growth factor B	VEGFA;VEGFB	VEGF;VRF
7500	KDR-L-VEGF189 complex	Human	None	None	P15692-13;P35968	7422;3791	MI:0051-fluorescence technology	None	None	None	None	28392095	None	None	L-VEGF189 is a splice variant of VEGFA.	Homo sapiens (Human);Homo sapiens (Human)	Isoform L-VEGF189 of Vascular endothelial growth factor A;Vascular endothelial growth factor receptor 2	VEGFA;KDR	VEGF;FLK1 VEGFR2
7501	NRP1-VEGF189 complex	Human	None	None	O14786;P15692-2	8829;7422	MI:0004-affinity chromatography technology	None	None	None	None	25519242	None	None	VEGF189 is a splice variant of VEGFA.	Homo sapiens (Human);Homo sapiens (Human)	Neuropilin-1;Isoform VEGF189 of Vascular endothelial growth factor A	NRP1;VEGFA	NRP, VEGF165R;VEGF
7504	CD44-ERK1-ERK2-RHAMM complex	Human	Rhamm-CD44-ERK1,2 complex; CD44-ERK1,2-HMMR complex; CD44-ERK1,2-RHAMM complex	MDA-MB-231 cells	O75330;P16070;P27361;P28482	3161;960;5595;5594	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0070371;GO:0048870	ERK1 and ERK2 cascade;cell motility	None	None	17392272	None	Rhamm and CD44 act together in a hyaluronan-dependent mechanism to coordinate sustained signaling through ERK1,2, leading to high basal motility of invasive breast cancer cells.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Hyaluronan mediated motility receptor;CD44 antigen;Mitogen-activated protein kinase 3;Mitogen-activated protein kinase 1	HMMR;CD44;MAPK3;MAPK1	IHABP; RHAMM;LHR MDU2 MDU3 MIC4;ERK1 PRKM3;ERK2 PRKM1 PRKM2
7506	KCNB1-KCNE2 complex	Human	Kv2.1-MiRP1 complex, Potassium channel complex (KCNB1, KCNE2)	CHO cotransfected cells	Q14721;Q9Y6J6	3745;9992	MI:0046-experimental knowledge based	GO:0005267;GO:0034705;GO:0008076;GO:0071805;GO:0005249	potassium channel activity;potassium channel complex;voltage-gated potassium channel complex;potassium ion transmembrane transport;voltage-gated potassium channel activity	None	None	19219384	Kv2.1 is a voltage-gated potassium (Kv) channel alpha-subunit expressed in mammalian heart and brain. MinK-related peptides (MiRPs), encoded by KCNE genes, are single-transmembrane domain ancillary subunits that form complexes with Kv channel alpha-subunits to modify their function. Human MinK slowed Kv2.1 activation 25%, while human MiRP1 slowed Kv2.1 activation and deactivation twofold. Inherited mutations in human MinK and MiRP1, previously associated with LQTS, were also evaluated. D76N-MinK and S74L-MinK reduced Kv2.1 current density (threefold and 40%, respectively) and slowed deactivation (60% and 80%, respectively). Compared to wild-type human MiRP1-Kv2.1 complexes, channels formed with M54T- or I57T-MiRP1 showed greatly slowed activation (tenfold and fivefold, respectively).	Mutations in human MinK (KCNE1) and MiRP1 (KCNE2) are associated with inherited and acquired forms of long QT syndrome (LQTS).	None	Homo sapiens (Human);Homo sapiens (Human)	Potassium voltage-gated channel subfamily B member 1;Potassium voltage-gated channel subfamily E member 2	KCNB1;KCNE2	None;None
7507	KCNB1-KCNE1 complex	Human	Kv2.1-MinK complex; Potassium channel complex (KCNB1, KCNE1)	CHO cotransfected cells	P15382;Q14721	3753;3745	MI:0046-experimental knowledge based	GO:0005267;GO:0034705;GO:0008076;GO:0071805;GO:0005249	potassium channel activity;potassium channel complex;voltage-gated potassium channel complex;potassium ion transmembrane transport;voltage-gated potassium channel activity	None	None	19219384	Kv2.1 is a voltage-gated potassium (Kv) channel alpha-subunit expressed in mammalian heart and brain. MinK-related peptides (MiRPs), encoded by KCNE genes, are single-transmembrane domain ancillary subunits that form complexes with Kv channel alpha-subunits to modify their function. Human MinK slowed Kv2.1 activation 25%, while human MiRP1 slowed Kv2.1 activation and deactivation twofold. Inherited mutations in human MinK and MiRP1, previously associated with LQTS, were also evaluated. D76N-MinK and S74L-MinK reduced Kv2.1 current density (threefold and 40%, respectively) and slowed deactivation (60% and 80%, respectively). Compared to wild-type human MiRP1-Kv2.1 complexes, channels formed with M54T- or I57T-MiRP1 showed greatly slowed activation (tenfold and fivefold, respectively).	Mutations in human MinK (KCNE1) and MiRP1 (KCNE2) are associated with inherited and acquired forms of long QT syndrome (LQTS).	None	Homo sapiens (Human);Homo sapiens (Human)	Potassium voltage-gated channel subfamily E member 1;Potassium voltage-gated channel subfamily B member 1	KCNE1;KCNB1	None;None
7509	IL1RAP-IL1RL1-KIT complex	Human	None	HMC-1.1 cells	P10721;Q01638;Q9NPH3	3815;9173;3556	MI:0019-coimmunoprecipitation	GO:0008063	Toll signaling pathway	None	None	20200353	Kit and IL1RAP (IL-1RAcP) interact constitutively and IL1RL1 (IL-33R) joins this complex upon ligand binding.  Association of IL1RL1 with KIT depends on cholesterol-rich membrane microdomains.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mast/stem cell growth factor receptor Kit;Interleukin-1 receptor-like 1;Interleukin-1 receptor accessory protein	KIT;IL1RL1;IL1RAP	SCFR;DER4 ST2 T1;C3orf13 IL1R3
7510	IL1RAP-KIT complex	Human	None	HMC-1.1 cells	P10721;Q9NPH3	3815;3556	MI:0019-coimmunoprecipitation	GO:0008063	Toll signaling pathway	None	None	20200353	IL1RAP (c-Kit) interacts constitutively with IL-1RAcP and not ligand-dependent.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Mast/stem cell growth factor receptor Kit;Interleukin-1 receptor accessory protein	KIT;IL1RAP	SCFR;C3orf13 IL1R3
7513	PAQR3-SCAP-SREBF2 complex	Human	PAQR3-SCAP-SREBP2 complex	HEK293T cells	Q12770;Q12772;Q6TCH7	22937;6721;152559	MI:0019-coimmunoprecipitation	GO:0042632;GO:0005794	cholesterol homeostasis;Golgi apparatus	34.01.07;70.08	cholesterol homeostasis;Golgi	26311497	PAQR3 interacts with Scap/SREBP and promotes localization of Scap/SREBP in the Golgi, resulting in enhanced SREBP processing and cellular cholesterol level.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Sterol regulatory element-binding protein cleavage-activating protein;Sterol regulatory element-binding protein 2;Progestin and adipoQ receptor family member 3	SCAP;SREBF2;PAQR3	KIAA0199;BHLHD2, SREBP2;None
7514	SCAP-SREBF2 complex	Human	SCAP-SREBP2 complex	HEK293T cells	Q12770;Q12772	22937;6721	MI:0019-coimmunoprecipitation	GO:0042632;GO:0005794	cholesterol homeostasis;Golgi apparatus	34.01.07;70.08	cholesterol homeostasis;Golgi	26311497	PAQR3 interacts with Scap/SREBP and promotes localization of Scap/SREBP in the Golgi, resulting in enhanced SREBP processing and cellular cholesterol level.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Sterol regulatory element-binding protein cleavage-activating protein;Sterol regulatory element-binding protein 2	SCAP;SREBF2	KIAA0199;BHLHD2, SREBP2
7515	PAQR3-SCAP-complex	Human	None	HEK293T cells	Q12770;Q6TCH7	22937;152559	MI:0019-coimmunoprecipitation	GO:0042632;GO:0005794	cholesterol homeostasis;Golgi apparatus	34.01.07;70.08	cholesterol homeostasis;Golgi	26311497	PAQR3 interacts with Scap/SREBP and promotes localization of Scap/SREBP in the Golgi, resulting in enhanced SREBP processing and cellular cholesterol level.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Sterol regulatory element-binding protein cleavage-activating protein;Progestin and adipoQ receptor family member 3	SCAP;PAQR3	KIAA0199;None
7516	PAQR3-SREBF2 complex	Human	PAQR3-SREBP2 complex	HEK293T cells	Q12772;Q6TCH7	6721;152559	MI:0019-coimmunoprecipitation	GO:0042632;GO:0005794	cholesterol homeostasis;Golgi apparatus	34.01.07;70.08	cholesterol homeostasis;Golgi	26311497	PAQR3 interacts with Scap/SREBP and promotes localization of Scap/SREBP in the Golgi, resulting in enhanced SREBP processing and cellular cholesterol level.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Sterol regulatory element-binding protein 2;Progestin and adipoQ receptor family member 3	SREBF2;PAQR3	BHLHD2, SREBP2;None
7517	Ubiquitin E3 ligase (CUL3, KLHL7, RBX1)	Human	None	HCT116 cells	P62877;Q13618;Q8IXQ5	9978;8452;55975	MI:0007-anti tag coimmunoprecipitation	GO:0031461;GO:0043161	cullin-RING ubiquitin ligase complex;proteasome-mediated ubiquitin-dependent protein catabolic process	14.13.01.01	proteasomal degradation (ubiquitin/proteasomal pathway)	21828050	None	Ala-153 mutations in KLHL7 that attenuate its interaction and co-localization with Cul3 cause autosomal dominant retinitis pigmentosa.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase RBX1;Cullin-3;Kelch-like protein 7	RBX1;CUL3;KLHL7	RNF75 ROC1;KIAA0617;None
7518	Ubiquitin E3 ligase (CUL3, KLHL8)	Human	None	293T cells	Q13618;Q9P2G9	8452;57563	MI:0007-anti tag coimmunoprecipitation	GO:0031461;GO:0043161	cullin-RING ubiquitin ligase complex;proteasome-mediated ubiquitin-dependent protein catabolic process	14.13.01.01	proteasomal degradation (ubiquitin/proteasomal pathway)	19158078	Rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction is polyubiquitinated by a KLHL8-containing E3 ligase.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cullin-3;Kelch-like protein 8	CUL3;KLHL8	KIAA0617;KIAA1378
7520	INSIG1-SCAP complex	Human	None	HEK293T cells	O15503;Q12770	3638;22937	MI:0019-coimmunoprecipitation	GO:0016125;GO:0005783	sterol metabolic process;endoplasmic reticulum	70.07	endoplasmic reticulum	26311497	Under cholesterol sufficient condition, Insigs act as anchor proteins to retain Scap/SREBP in the ER. Immunoprecipitation of PAQR3 could only bring down Scap but not Insig-1. Likewise, immunoprecipitation of Insig-1 could only bring down Scap but not PAQR3. Overexpression of PAQR3 was able to reduce Insig/Scap interaction in a dose-dependent manner. The results indicated that PAQR3 and Insig can mutually exclusively compete for Scap interaction, leading to either activation of SREBP by anchoring it to the GA (via PAQR3) or inactivation of SREBP by anchoring it to the ER (via Insig). The mutually exclusive interaction between Scap and PAQR3 or Insig-1 is regulated by cholesterol level.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Insulin-induced gene 1 protein;Sterol regulatory element-binding protein cleavage-activating protein	INSIG1;SCAP	None;KIAA0199
7521	INSIG1-PAQR3 complex	Human	None	HEK293T cells	O15503;Q6TCH7	3638;152559	MI:0019-coimmunoprecipitation	GO:0005783;GO:0016125	endoplasmic reticulum;sterol metabolic process	70.07	endoplasmic reticulum	26311497	Under cholesterol sufficient condition, Insigs act as anchor proteins to retain Scap/SREBP in the ER. Immunoprecipitation of PAQR3 could only bring down Scap but not Insig-1. Likewise, immunoprecipitation of Insig-1 could only bring down Scap but not PAQR3. Overexpression of PAQR3 was able to reduce Insig/Scap interaction in a dose-dependent manner. The results indicated that PAQR3 and Insig can mutually exclusively compete for Scap interaction, leading to either activation of SREBP by anchoring it to the GA (via PAQR3) or inactivation of SREBP by anchoring it to the ER (via Insig). The mutually exclusive interaction between Scap and PAQR3 or Insig-1 is regulated by cholesterol level.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Insulin-induced gene 1 protein;Progestin and adipoQ receptor family member 3	INSIG1;PAQR3	None;None
7522	Ubiquitin E3 ligase (CUL3, KLHL12, PEF1, PDCD6)	Human	None	HEK293T cells	O75340;Q13618;Q53G59;Q9UBV8	10016;8452;59349;553115	MI:0007-anti tag coimmunoprecipitation	GO:0031461;GO:0030127;GO:0051592;GO:0043161	cullin-RING ubiquitin ligase complex;COPII vesicle coat;response to calcium ion;proteasome-mediated ubiquitin-dependent protein catabolic process	14.13.01.01	proteasomal degradation (ubiquitin/proteasomal pathway)	27716508	CUL3 and its adaptor KLHL12 require two calcium-binding proteins, PEF1 and PDCD6 (ALG2), for recognition of their substrate SEC31. PEF1 and ALG2 form a target-specific co-adaptor that translates a transient rise in cytosolic calcium levels into more persistent SEC31 ubiquitylation, which in turn triggers formation of large COPII coats and promotes collagen secretion.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Programmed cell death protein 6;Cullin-3;Kelch-like protein 12;Peflin	PDCD6;CUL3;KLHL12;PEF1	ALG2;KIAA0617;C3IP1;ABP32
7523	Ubiquitin E3 ligase (CUL3, KLHL9, KLHL13, RBX1)	Human	None	HeLa cells	P62877;Q13618;Q9P2J3;Q9P2N7	9978;8452;55958;90293	MI:0007-anti tag coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0031461;GO:1902410;GO:0043161	cullin-RING ubiquitin ligase complex;mitotic cytokinetic process;proteasome-mediated ubiquitin-dependent protein catabolic process	14.13.01.01	proteasomal degradation (ubiquitin/proteasomal pathway)	17543862	Ubiquitin E3 ligase (CUL3, KLHL9, KLHL13, RBX1) is essential for mitotic division. In complex with the substrate-specific adaptors KLHL9 and KLHL13, CUL3 is required for correct chromosome alignment in metaphase, proper midzone and midbody formation, and completion of cytokinesis. The complex regulates Aurora B localization on mitotic chromosomes possibly by inhibiting its efficient removal from chromosome arms.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase RBX1;Cullin-3;Kelch-like protein 9;Kelch-like protein 13	RBX1;CUL3;KLHL9;KLHL13	RNF75 ROC1;KIAA0617;KIAA1354;BKLHD2 KIAA1309
7524	Ubiquitin E3 ligase (CUL3, KLHL20, RBX1)	Human	None	HEK 293T cells	P62877;Q13618;Q9Y2M5	9978;8452;27252	MI:0007-anti tag coimmunoprecipitation	GO:0031461;GO:1904093;GO:0043161	cullin-RING ubiquitin ligase complex;negative regulation of autophagic cell death;proteasome-mediated ubiquitin-dependent protein catabolic process	14.13.01.01	proteasomal degradation (ubiquitin/proteasomal pathway)	20389280	Death-associated protein kinase (DAPK) is a mediator of interferon-induced cell death. The Ubiquitin E3 ligase (CUL3, KLHL20, RBX1) complex promotes DAPK polyubiquitination, thereby inducing the proteasomal degradation of DAPK and attenuation of autophagy. In interferon-treated cells, the enrichment and sequestration of KLHL20 in PML nuclear bodies disrupts KLHL20\u2013DAPK complex, thus impairing DAPK ubiquitination by KLHL20.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase RBX1;Cullin-3;Kelch-like protein 20	RBX1;CUL3;KLHL20	RNF75 ROC1;KIAA0617;KLEIP,KLHLX
7525	Ubiquitin E3 ligase (CUL3, KLHL24, RBX1)	Human	None	HEK 293T cells	P62877;Q13618;Q6TFL4	9978;8452;54800	MI:0007-anti tag coimmunoprecipitation	GO:0031461;GO:0043161	cullin-RING ubiquitin ligase complex;proteasome-mediated ubiquitin-dependent protein catabolic process	14.13.01.01	proteasomal degradation (ubiquitin/proteasomal pathway)	27798626	None	Defects in keratin 14 causes skin fragility, epitomized by epidermolysis bullosa (EB), a life-threatening disorder. Stabilizing mutations of Ubiquitin E3 ligase (CUL3, KLHL24, RBX1) causes loss of keratin 14 and human skin fragility.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase RBX1;Cullin-3;Kelch-like protein 24	RBX1;CUL3;KLHL24	RNF75 ROC1;KIAA0617;DRE1
7526	Ubiquitin E3 ligase (CUL3, KLHL25)	Human	None	HEK293 cells	Q13618;Q9H0H3	8452;64410	MI:0007-anti tag coimmunoprecipitation	GO:0031461;GO:0043161;GO:0006417	cullin-RING ubiquitin ligase complex;proteasome-mediated ubiquitin-dependent protein catabolic process;regulation of translation	14.13.01.01;12.07	proteasomal degradation (ubiquitin/proteasomal pathway);translational control	22578813	Translation via eIF4E activity is controlled by a family of repressor proteins, termed 4E-binding proteins (E4-BPs). Ubiquitin E3 ligase (CUL3, KLHL25) complex plays a key role in ubiquitination and subsequent degradation of the hypophosphorylated 4E-BP1.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cullin-3;Kelch-like protein 25	CUL3;KLHL25	KIAA0617;ENC2
7527	LAF177-LAF331 complex	Human	None	None	O95278-1;O95278-7	7957;7957	MI:0096-pull down	None	None	None	None	22036712	The phosphatase activity of the laf177\u2013laf331 and laf177\u2013laf317 complexes was found to be lower than that of laf177 (PMID:22036712).	None	LAF177 (O95278-7) and LAF331 (O95278-1) are splice variants of EPM2A.	Homo sapiens (Human);Homo sapiens (Human)	Isoform 1 of Laforin;Isoform 7 of Laforin	EPM2A;EPM2A	None;None
7528	laf177-laf317 complex	Human	None	None	O95278-2;O95278-7	7957;7957	MI:0096-pull down	None	None	None	None	22036712	The phosphatase activity of the laf177\u2013laf331 and laf177\u2013laf317 complexes was found to be lower than that of laf177 (PMID:22036712).	None	LAF177 (O95278-7) and LAF317  (O95278-2) are splice variants of EPM2A.	Homo sapiens (Human);Homo sapiens (Human)	Isoform 2 of Laforin;Isoform 7 of Laforin	EPM2A;EPM2A	None;None
7529	APP-Abeta42-VDAC1 complex	Human	APP(full length)-Abeta(1-42)-VDAC1 complex	frontal and entorhinal cortex of human brains affected by AD; SHSY-5Y cells; hippocampal HT22 cells	P05067;P05067-PRO_0000000092;P21796	351;351;7416	MI:0019-coimmunoprecipitation;MI:0047-far western blotting;MI:0051-fluorescence technology	GO:0005739;GO:0045121;GO:0008308;GO:0008219	mitochondrion;membrane raft;voltage-gated anion channel activity;cell death	70.16;40.10	mitochondrion;cell death	25168729	Voltage-dependent anion channel (VDAC) is a mitochondrial protein abundantly found in neuronal lipid rafts. In these membrane domains, VDAC is associated with a complex of signalling proteins that trigger neuroprotective responses. It is demonstrated that VDAC1 associates with APP (100 kDa full-length APP) and Abeta (1-42 fragment, oligomeric) in lipid rafts of neurons. Interaction of VDAC1 with APP was observed in lipid rafts from the frontal and entorhinal cortex of human brains affected by AD at early stages (I-IV/0-B of Braak and Braak). Furthermore, Abeta exposure enhanced the dephosphorylation of VDAC1 that correlated with cell death. Both effects were reverted in the presence of tyrosine phosphatase inhibitors.	None	VDAC1 associates with APP (100 kDa full-length APP) and Abeta (1-42 fragment of APP, oligomeric).	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Amyloid-beta precursor protein;Amyloid-beta precursor protein;Voltage-dependent anion-selective channel protein 1	APP;APP;VDAC1	A4 AD1;A4 AD1;VDAC
7533	Ubiquitin E3 ligase (CUL3, KLHL42)	Human	None	HEK293 cells	Q13618;Q9P2K6	8452;57542	MI:0007-anti tag coimmunoprecipitation;MI:0018-two hybrid	GO:0031461;GO:1901990	cullin-RING ubiquitin ligase complex;regulation of mitotic cell cycle phase transition	None	None	19261606	Overexpression of KLHL42 results in an increased microtubule density, cytoplasmic bridges between cells, and bi-nucleated cells. In contrast, knockdown of KLHL42 protein levels by double strand RNA results in a dramatic reduction in the cellular microtubule framework. Thus, Ubiquitin E3 ligase (CUL3, KLHL42) is required for normal mitosis in mammalian cells.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cullin-3;Kelch-like protein 42	CUL3;KLHL42	KIAA0617;KIAA1340,KLHDC5
7534	CTNNB1-EPCAM-FHL2-LEF1 complex	Human	None	FaDu cells	P16422;P35222;Q14192;Q9UJU2	4072;1499;2274;51176	MI:0029-cosedimentation through density gradient	GO:0005634;GO:0006355;GO:0007165	nucleus;regulation of DNA-templated transcription;signal transduction	70.10;11.02.03.04;30	nucleus;transcriptional control;CELLULAR COMMUNICATION/SIGNAL TRANSDUCTION MECHANISM	19136966	EpCAM as a mitogenic signal transducer  involves shedding of its ectodomain EpEX and nuclear translocation of its intracellular domain EpICD. Endogenous EpICD was detected in the nuclear CTNNB1-EPCAM-FHL2-LEF1 complex with a native molecular size of 650 K.	In patients, EpICD was found in nuclei of colon carcinoma but not of normal tissue.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Epithelial cell adhesion molecule;Catenin beta-1;Four and a half LIM domains protein 2;Lymphoid enhancer-binding factor 1	EPCAM;CTNNB1;FHL2;LEF1	GA733-2 M1S2 M4S1 MIC18 TACSTD1 TROP1;CTNNB;DRAL SLIM3;None
7535	CD44-LRP1 complex	Human	None	FTC-133 human follicular thyroid carcinoma cell line	P16070;Q07954	960;4035	MI:0007-anti tag coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0006898;GO:0045121;GO:0007155	receptor-mediated endocytosis;membrane raft;cell adhesion	20.09.18.09.01.01;34.07	receptor-mediated endocytosis;cell adhesion	22711991	CD44 is routed through early endosomes toward lysosomes in a LRP1-dependent pathway. LRP1-mediated internalization of CD44 proceeds mostly via clathrin-coated pits.	LRP1-mediated endocytosis of CD44 controls tumor cell attachment.	None	Homo sapiens (Human);Homo sapiens (Human)	CD44 antigen;Prolow-density lipoprotein receptor-related protein 1	CD44;LRP1	LHR MDU2 MDU3 MIC4;A2MR APR
7540	KMT2E-OGT-USP7 complex	Human	None	HEK293T cells	O15294;Q8IZD2;Q93009	8473;55904;7874	MI:0007-anti tag coimmunoprecipitation;MI:0071-molecular sieving;MI:0416-fluorescence microscopy	GO:0005634;GO:0007049;GO:0030097;GO:0006355	nucleus;cell cycle;hemopoiesis;regulation of DNA-templated transcription	70.10;10.03;41.05.18;11.02.03.04	nucleus;cell cycle;hemopoiesis;transcriptional control	26678539	The MLL5 protein stability is cooperatively regulated by O-GlcNAc transferase (OGT) and ubiquitin-specific protease 7 (USP7).	MLL5 protein levels are correlated with expression of OGT and USP7 in primary cervical adenocarcinomas.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit;Inactive histone-lysine N-methyltransferase 2E;Ubiquitin carboxyl-terminal hydrolase 7	OGT;KMT2E;USP7	None;MLL5;HAUSP
7541	KNTC1-ZW10-ZWILCH complex	Human	None	HeLa cells	O43264;P50748;Q9H900	9183;9735;55055	MI:0007-anti tag coimmunoprecipitation;MI:0416-fluorescence microscopy	GO:0007093	mitotic cell cycle checkpoint signaling	None	None	15824131	The KNTC1-ZW10-ZWILCH complex is essential for the mitotic checkpoint.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Centromere/kinetochore protein zw10 homolog;Kinetochore-associated protein 1;Protein zwilch homolog	ZW10;KNTC1;ZWILCH	None;KIAA0166;None
7542	KNL1-MIS12-NDC80-SPC24-ZWINT complex	Human	None	HeLa cells	O14777;O95229;Q8NBT2;Q8NG31;Q9H081	10403;11130;147841;57082;79003	MI:0007-anti tag coimmunoprecipitation;MI:0416-fluorescence microscopy	GO:0007093	mitotic cell cycle checkpoint signaling	None	None	15824131	ZWINT has a crucial role in the recruitment of ZW10 to unattached kinetochores.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Kinetochore protein NDC80 homolog;ZW10 interactor;Kinetochore protein Spc24;Kinetochore scaffold 1;Protein MIS12 homolog	NDC80;ZWINT;SPC24;KNL1;MIS12	HEC HEC1 KNTC2;None;SPBC24;CASC5,KIAA1570;None
7544	DKK1-KREMEN1-LRP6 complex	Human	None	HEK cells	O75581;O94907;Q96MU8	4040;22943;83999	MI:0114-x-ray crystallography	None	None	None	None	27524201	DKK1-KREMEN1-LRP6 complex is also characterized in PMID 12050670.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Low-density lipoprotein receptor-related protein 6;Dickkopf-related protein 1;Kremen protein 1	LRP6;DKK1;KREMEN1	None;None;KREMEN,KRM1
7545	BORC complex	Human	None	HeLa cells	O95295;P78537;Q6QNY1;Q969J3;Q96B45;Q96FH0;Q96GS4;Q9BQD3	23557;2647;282991;118426;119032;729991;54785;79036	MI:0007-anti tag coimmunoprecipitation;MI:0071-molecular sieving	GO:0099078	BORC complex	None	None	25898167	BORC complex associates peripherally with the lysosomal membrane, where it functions to recruit the small GTPase Arl8. This initiates a chain of interactions that promotes the kinesin-dependent movement of lysosomes toward the plus ends of microtubules in the peripheral cytoplasm.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	SNARE-associated protein Snapin;Biogenesis of lysosome-related organelles complex 1 subunit 1;Biogenesis of lysosome-related organelles complex 1 subunit 2;BLOC-1-related complex subunit 5;BLOC-1-related complex subunit 7;BLOC-1-related complex subunit 8;BLOC-1-related complex subunit 6;KxDL motif-containing protein 1	SNAPIN;BLOC1S1;BLOC1S2;BORCS5;BORCS7;BORCS8;BORCS6;KXD1	BLOC1S7 SNAP25BP SNAPAP;BLOS1 GCN5L1 RT14;BLOS2 CEAP;LOH12CR1;C10orf32;MEF2BNB;C17orf59;C19orf50
7548	MAPK6-MAPKAPK5-SEPT7 complex	Human	ERK3-MK5-SEPT7 complex	HEK293	Q16181;Q16659;Q8IW41	989;5597;8550	MI:0055-fluorescent resonance energy transfer	None	None	None	None	22508986	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Septin-7;Mitogen-activated protein kinase 6;MAP kinase-activated protein kinase 5	SEPTIN7;MAPK6;MAPKAPK5	CDC10 SEPT7;ERK3,PRKM6;PRAK
7549	CALM1-KCNE1-KCNQ1 complex	Human	None	HEK293 cells	P0DP23;P15382;P51787	801;3753;3784	MI:0018-two hybrid;MI:0019-coimmunoprecipitation;MI:0047-far western blotting;MI:0096-pull down	GO:0086008;GO:0005249;GO:0034705;GO:0015267	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization;voltage-gated potassium channel activity;potassium channel complex;channel activity	20.03.01	channel / pore class transport	16556865	Calmodulin is essential for cardiac IKS channel gating and assembly. KCNE1 forms a ternary complex with wild-type KCNQ1 and Ca2+-CaM. CaM binding to KCNQ1 is essential for correct channel folding and assembly and for conferring Ca2+-sensitive IKS-current stimulation, which increases the cardiac repolarization reserve and therefore prevents the risk of ventricular arrhythmias.	Long-QT mutations located in the KCNQ1 C-terminus impair calmodulin (CaM) binding, which affects both channel gating and assembly.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Calmodulin-1;Potassium voltage-gated channel subfamily E member 1;Potassium voltage-gated channel subfamily KQT member 1	CALM1;KCNE1;KCNQ1	CALM CAM CAM1;None;KCNA8 KCNA9 KVLQT1
7551	SMYLE 1 complex	Human	AKAP9-CDK5RAP2-EB1-EB3-PKAcalpha-PKAr2alpha-PKAr2beta-SMYLE complex	HEK293F cells	P13861;P17612;P31323;Q15691;Q5VU43-13;Q96SN8;Q99996;Q9UPY8	5576;5566;5577;22919;653513;55755;10142;22924	MI:0030-cross-linking study;MI:0096-pull down	GO:0010968	regulation of microtubule nucleation	None	None	29162697	This macromolecular complex is localized at the centrosome and may define its function in microtubule assembly, directed cell motility, and orientation of cell division. (PMID:29162697)	None	SMYLE (Q5VU43-13) is a splice variant of PDE4DIP.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	cAMP-dependent protein kinase type II-alpha regulatory subunit;cAMP-dependent protein kinase catalytic subunit alpha;cAMP-dependent protein kinase type II-beta regulatory subunit;Microtubule-associated protein RP/EB family member 1;Isoform 13 of Myomegalin;CDK5 regulatory subunit-associated protein 2;A-kinase anchor protein 9;Microtubule-associated protein RP/EB family member 3	PRKAR2A;PRKACA;PRKAR2B;MAPRE1;PDE4DIP;CDK5RAP2;AKAP9;MAPRE3	PKR2, PRKAR2;PKACA;None;None;CMYA2 KIAA0454 KIAA0477 MMGL;CEP215 KIAA1633;AKAP350 AKAP450 KIAA0803;None
7552	SMYLE 2 complex	Human	DE4DIP(SMYLE variant)-EB1-EB3 complex	None	Q15691;Q5VU43-13;Q9UPY8	22919;653513;22924	MI:0030-cross-linking study;MI:0096-pull down	GO:0010968	regulation of microtubule nucleation	None	None	29162697	None	None	SMYLE (Q5VU43-13) is a splice variant of PDE4DIP.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Microtubule-associated protein RP/EB family member 1;Isoform 13 of Myomegalin;Microtubule-associated protein RP/EB family member 3	MAPRE1;PDE4DIP;MAPRE3	None;CMYA2 KIAA0454 KIAA0477 MMGL;None
7555	KEOPS complex	Human	EKC complex	293T cells	Q14657;Q96S44;Q9NPF4;Q9Y3C4	8270;112858;55644;51002	MI:0007-anti tag coimmunoprecipitation	GO:0006412;GO:0000723	translation;telomere maintenance	12.04	translation	22912744	None	Mutations in KEOPS-complex genes cause Galloway-Mowat syndrome (GAMOS), an autosomal-recessive disease characterized by the combination of early-onset nephrotic syndrome (SRNS) and microcephaly with brain anomalies (PMID:28805828).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	EKC/KEOPS complex subunit LAGE3;EKC/KEOPS complex subunit TP53RK;tRNA N6-adenosine threonylcarbamoyltransferase;EKC/KEOPS complex subunit TPRKB	LAGE3;TP53RK;OSGEP;TPRKB	DXS9879E ESO3 ITBA2;C20orf64,PRPK;GCPL1;None
7556	PRAME complex	Human	None	K562 cells	P62877;P78395;Q13617;Q14657;Q15369;Q15370;Q9NPF4	9978;23532;8453;8270;6921;6923;55644	MI:0007-anti tag coimmunoprecipitation	None	None	None	None	22912744	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase RBX1;Melanoma antigen preferentially expressed in tumors;Cullin-2;EKC/KEOPS complex subunit LAGE3;Elongin-C;Elongin-B;tRNA N6-adenosine threonylcarbamoyltransferase	RBX1;PRAME;CUL2;LAGE3;ELOC;ELOB;OSGEP	RNF75 ROC1;MAPE OIP4;None;DXS9879E ESO3 ITBA2;TCEB1;TCEB2;GCPL1
7557	LGR4-RSPO supercomplex	Human	None	HEK293T cells	O00401;O14641;O60610;P36507;P46940;P49023;Q02750;Q05397;Q9BXB1;Q9BXY4	8976;1856;1729;5605;8826;5829;5604;5747;55366;84870	MI:0007-anti tag coimmunoprecipitation;MI:0416-fluorescence microscopy	GO:0048041;GO:0016055	focal adhesion assembly;Wnt signaling pathway	30.05.02.20	Wnt signalling pathway	24639526	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Actin nucleation-promoting factor WASL;Segment polarity protein dishevelled homolog DVL-2;Protein diaphanous homolog 1;Dual specificity mitogen-activated protein kinase kinase 2;Ras GTPase-activating-like protein IQGAP1;Paxillin;Dual specificity mitogen-activated protein kinase kinase 1;Focal adhesion kinase 1;Leucine-rich repeat-containing G-protein coupled receptor 4;R-spondin-3	WASL;DVL2;DIAPH1;MAP2K2;IQGAP1;PXN;MAP2K1;PTK2;LGR4;RSPO3	None;None;DIAP1;MEK2 MKK2 PRKMK2;KIAA0051;None;MEK1 PRKMK1;FAK, FAK1;GPR48;PWTSR,THSD2
7559	INSC-LGN-PAR3 complex	Human	INSC-GPSM2-PARD3 complex	COS-7 cells	P81274;Q1MX18;Q8TEW0	29899;387755;56288	MI:0019-coimmunoprecipitation	GO:0030010	establishment of cell polarity	None	None	16458856	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	G-protein-signaling modulator 2;Protein inscuteable homolog;Partitioning defective 3 homolog	GPSM2;INSC;PARD3	LGN;None;PAR3 PAR3A
7561	NCKAP1-WASF3 complex	Human	None	MDA-MB-231 and Hs578T cells	Q9UPY6;Q9Y2A7	10810;10787	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0031532	actin cytoskeleton reorganization	None	None	27432794	None	Destabilization of the complex lowers the invasive capacity of breast, prostate, and colon cancer cells.	None	Homo sapiens (Human);Homo sapiens (Human)	Actin-binding protein WASF3;Nck-associated protein 1	WASF3;NCKAP1	KIAA0900 SCAR3 WAVE3;HEM2 KIAA0587 NAP1
7562	NCKAP1-WASF3-RAC1 complex	Human	None	MDA-MB-231 and Hs578T cells	P63000;Q9UPY6;Q9Y2A7	5879;10810;10787	MI:0019-coimmunoprecipitation	GO:0031532	actin cytoskeleton reorganization	None	None	27432794	None	RAC1 binding to the WASF3-NCKAP1 complex is required for the invasive signaling axis in breast cancer cells	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Ras-related C3 botulinum toxin substrate 1;Actin-binding protein WASF3;Nck-associated protein 1	RAC1;WASF3;NCKAP1	TC25;KIAA0900 SCAR3 WAVE3;HEM2 KIAA0587 NAP1
7563	LARP1-PABPC1-RYDEN complex	Human	None	HepG2 cells	P11940;Q6PKG0;Q9NUL5	26986;23367;55337	MI:0007-anti tag coimmunoprecipitation	GO:0051607	defense response to virus	None	None	26735137	None	RYDEN is a interferon-stimulated cellular inhibitor against replication of dengue virus and other viruses. This inhibition is achieved by forming a protein complex with LARP1 and PABPC1.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Polyadenylate-binding protein 1;La-related protein 1;Shiftless antiviral inhibitor of ribosomal frameshifting protein	PABPC1;LARP1;SHFL	PAB1 PABP PABP1 PABPC2;KIAA0731,LARP;C19orf66 FLJ11286 IRAV RYDEN SFL
7564	LGR5-RNF43-RSPO1 complex	Human	None	HEK293TS cells	O75473;Q2MKA7;Q68DV7	8549;284654;54894	MI:0114-x-ray crystallography	GO:0016055	Wnt signaling pathway	30.05.02.20	Wnt signalling pathway	23756651	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Leucine-rich repeat-containing G-protein coupled receptor 5;R-spondin-1;E3 ubiquitin-protein ligase RNF43	LGR5;RSPO1;RNF43	GPR49 GPR67;None;None
7566	7SK RNP complex	Human	CDK9-CCNT1-HEXIM1-LARP7 complex	HeLa cells	O60563;O94992;P50750;Q4G0J3	904;10614;1025;51574	MI:0019-coimmunoprecipitation	GO:0045892	negative regulation of DNA-templated transcription	11.02.03.04.03	transcription repression	18483487	The CDK9-CCNT1-HEXIM1-LARP7 complex regulates not only viral but also cellular POLII class genes through the 7SK P-TEFb system.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cyclin-T1;Protein HEXIM1;Cyclin-dependent kinase 9;La-related protein 7	CCNT1;HEXIM1;CDK9;LARP7	None;CLP1, EDG1, HIS1, MAQ1;CDC2L4 TAK;None
7567	SUMO1-SYT7 complex	Human	None	pancreatic islet	O43581;P63165	9066;7341	MI:0019-coimmunoprecipitation	GO:0045920;GO:0046676	negative regulation of exocytosis;negative regulation of insulin secretion	None	None	21266332	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Synaptotagmin-7;Small ubiquitin-related modifier 1	SYT7;SUMO1	PCANAP7;SMT3C SMT3H3 UBL1
7568	LATS2-SIAH2-ZYX complex	Human	None	HEK293T cells, MDA-MB-231 cells	O43255;Q15942;Q9NRM7	6478;7791;26524	MI:0019-coimmunoprecipitation	GO:0035330;GO:0007179	regulation of hippo signaling;transforming growth factor beta receptor signaling pathway	30.05.01.18.01	TGF-beta-receptor signalling pathway	27030211	Zyxin forms a functional ternary complex with Siah2 and Lats2, thus enhances their binding and promotes Siah2-induced Lats2 degradation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase SIAH2;Zyxin;Serine/threonine-protein kinase LATS2	SIAH2;ZYX;LATS2	None;None;KPM
7571	Tmie-Pcdh15(CD1-2)-Lhfpl5 complex	Human	Tmie-Pcdh15(CD-2)-Lhfpl5 complex	None	Q4KL25;Q8K467;Q99PJ1-2	328789;20776;11994	MI:0019-coimmunoprecipitation	GO:0007605;GO:0050910	sensory perception of sound;detection of mechanical stimulus involved in sensory perception of sound	36.25.01.03	hearing	25467981	The transmembrane protein TMIE forms a ternary complex with the tip-link component PCDH15 and its binding partner TMHS/LHFPL5. Alternative splicing of the PCDH15 cytoplasmic domain regulates formation of this ternary complex. The multisubunit composition of the transduction complex and the regulation of complex assembly by alternative splicing is likely critical for regulating channel properties in different hair cells and along the cochlea\u2019s tonotopic axis (PMID:25467981).	None	CD1-2 (Q99PJ1-2) is a splice variant of Pcdh15.Tmie interacted with Pcdh15-CD2 (Q99PJ1-2) but only weakly with its close homologues Pcdh15-CD1 (Q99PJ1-1) and Pcdh5-CD3 (Q99PJ1-3).	Mus musculus (Mouse);Mus musculus (Mouse);Mus musculus (Mouse)	LHFPL tetraspan subfamily member 5 protein;Transmembrane inner ear expressed protein;Isoform 2 of Protocadherin-15	Lhfpl5;Tmie;Pcdh15	Tmhs;None;None
7574	APP-PSEN1 complex	Human	APP-PS1 complex	human 293 and HS683 cells; transfected CHO cells	P05067;P49768	351;5663	MI:0019-coimmunoprecipitation	GO:0034205;GO:0042987	amyloid-beta formation;amyloid precursor protein catabolic process	None	None	9223340	Mutations in the presenilin 1 (PS1) and presenilin 2 (PS2) genes increase the production of the highly amyloidogenic 42-residue form of amyloid beta-protein (Abeta42) in a variety of cell lines and transgenic mice. APP-PS complexes were recovered from human 293 and HS683 cells. APP was consistently found to coimmunoprecipitate with PS1 or PS2 proteins. Full maturation of APP was not required for the interaction; most APP molecules complexed with PS were solely N-glycosylated. Such complexes exist under physiological conditions. Treatment of cells with brefeldin A or incubation at 20 degrees C did not block complex formation, suggesting that the association between APP and PS occurs in part in the endoplasmic reticulum. Complex formation was detected for both wt and mutant PS and APP proteins. Deletion of the APP C-terminal domain did not abrogate complex formation, suggesting that the interaction does not occur in the cytoplasmic domains of the proteins.	Alzheimer	APP or presenilin proteins carrying familial AD-linked missense mutations still can form complexes.	Homo sapiens (Human);Homo sapiens (Human)	Amyloid-beta precursor protein;Presenilin-1	APP;PSEN1	A4 AD1;AD3 PS1 PSNL1
7575	APP-PSEN2 complex	Human	APP-PS2 complex	human 293 and HS683 cells; transfected CHO cells	P05067;P49810	351;5664	MI:0019-coimmunoprecipitation	GO:0042987;GO:0034205	amyloid precursor protein catabolic process;amyloid-beta formation	None	None	9223340	Mutations in the presenilin 1 (PS1) and presenilin 2 (PS2) genes increase the production of the highly amyloidogenic 42-residue form of amyloid beta-protein (Abeta42) in a variety of cell lines and transgenic mice. APP-PS complexes were recovered from human 293 and HS683 cells. APP was consistently found to coimmunoprecipitate with PS1 or PS2 proteins. Full maturation of APP was not required for the interaction; most APP molecules complexed with PS were solely N-glycosylated. Such complexes exist under physiological conditions. Treatment of cells with brefeldin A or incubation at 20 degrees C did not block complex formation, suggesting that the association between APP and PS occurs in part in the endoplasmic reticulum. Complex formation was detected for both wt and mutant PS and APP proteins. Deletion of the APP C-terminal domain did not abrogate complex formation, suggesting that the interaction does not occur in the cytoplasmic domains of the proteins.	Alzheimer	APP or presenilin proteins carrying familial AD-linked missense mutations still can form complexes.	Homo sapiens (Human);Homo sapiens (Human)	Amyloid-beta precursor protein;Presenilin-2	APP;PSEN2	A4 AD1;AD4 PS2 PSNL2 STM2
7576	VHL-ElonginB-ElonginC complex	Human	VBC complex; TCEB1-TCEB2-VHL complex	None	P40337;Q15369;Q15370	7428;6921;6923	MI:0071-molecular sieving	GO:0016567;GO:0043161	protein ubiquitination;proteasome-mediated ubiquitin-dependent protein catabolic process	14.07.05;14.13.01.01	modification by ubiquitination, deubiquitination;proteasomal degradation (ubiquitin/proteasomal pathway)	12004076	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	von Hippel-Lindau disease tumor suppressor;Elongin-C;Elongin-B	VHL;ELOC;ELOB	None;TCEB1;TCEB2
7577	APP-APBB1-KAT5 complex	Human	APP-Fe65-Tip60 complex	HEK293 cells; HeLa cells	O00213;P05067;Q92993	322;351;10524	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0016573;GO:0001221;GO:0009299;GO:0003677	histone acetylation;transcription coregulator binding;mRNA transcription;DNA binding	11.02.03;16.03.01	mRNA synthesis;DNA binding	11441186	The cytoplasmic tail of APP forms a multimeric complex with the nuclear adaptor protein Fe65 and the histone acetyltransferase Tip60. This complex potently stimulates transcription via heterologous Gal4- or LexA-DNA binding domains, suggesting that release of the cytoplasmic tail of APP by gamma-cleavage may function in gene expression.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Amyloid beta precursor protein binding family B member 1;Amyloid-beta precursor protein;Histone acetyltransferase KAT5	APBB1;APP;KAT5	FE65 RIR;A4 AD1;HTATIP, TIP60
7578	Shieldin complex	Human	None	HEK293T cells	Q6ZNX1;Q86V20;Q8IYI0;Q9UI95	None;54537;149840;10459	MI:0019-coimmunoprecipitation	GO:0006302	double-strand break repair	None	None	30022168	The authors propose a model in which the shieldin complex is the ultimate mediator of 53BP1-dependent DNA repair by binding ssDNA and occluding access to resection nucleases.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Shieldin complex subunit 3;Shieldin complex subunit 2;Shieldin complex subunit 1;Mitotic spindle assembly checkpoint protein MAD2B	SHLD3;SHLD2;SHLD1;MAD2L2	FLJ26957 RINN1;FAM35A,RINN2;C20orf196,RINN3;MAD2B REV7
7580	MAP2K4-MAP3K3-NBR1 complex	Human	NBR1-MEKK3-MKK4 complex	HEK293 cells	P45985;Q14596;Q99759	6416;4077;4215	MI:0019-coimmunoprecipitation	GO:0006954;GO:0046328	inflammatory response;regulation of JNK cascade	36.25.16.07	inflammatory response	25043814	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Dual specificity mitogen-activated protein kinase kinase 4;Next to BRCA1 gene 1 protein;Mitogen-activated protein kinase kinase kinase 3	MAP2K4;NBR1;MAP3K3	JNKK1 MEK4 MKK4 PRKMK4 SEK1 SERK1 SKK1;1A13B KIAA0049 M17S2;MAPKKK3 MEKK3
7581	ESR1-TRAP/Mediator coactivator complex	Human	ESRA-TRAP/Mediator  complex	HeLa nuclear cell extract	O43513;O60244;O75448;O75586;P03372;P24863;P49336;Q09472;Q13503;Q15648;Q15788;Q93074;Q9BTT4;Q9H944;Q9NVC6;Q9UHV7;Q9ULK4;Q9Y2X0	9443;9282;9862;10001;2099;892;1024;2033;9412;5469;8648;9968;84246;9477;9440;9969;9439;10025	MI:0047-far western blotting;MI:0096-pull down	GO:0009299;GO:0005634;GO:0006355;GO:0016592	mRNA transcription;nucleus;regulation of DNA-templated transcription;mediator complex	11.02.03;70.10;11.02.03.04	mRNA synthesis;nucleus;transcriptional control	11867769	The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro. All TRAP/Mediator components examined (with exception of TRAP150) were found to associate with ERalpha and ERbeta LBDs (C-terminal ligand binding domains) in an E2-dependent manner. The assays also show ligand-dependent interactions of SRC-1 and p300 with ER LBDs. These interactions are stronger for ERalpha than for ERbeta. No interactions of general transcription factors TFIIE (IIEalpha) and TFIIF (RAP30) were observed.	None	Gene name synonyms are MED7/CRSP33.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mediator of RNA polymerase II transcription subunit 7;Mediator of RNA polymerase II transcription subunit 14;Mediator of RNA polymerase II transcription subunit 24;Mediator of RNA polymerase II transcription subunit 6;Estrogen receptor;Cyclin-C;Cyclin-dependent kinase 8;Histone acetyltransferase p300;Mediator of RNA polymerase II transcription subunit 21;Mediator of RNA polymerase II transcription subunit 1;Nuclear receptor coactivator 1;Mediator of RNA polymerase II transcription subunit 12;Mediator of RNA polymerase II transcription subunit 10;Mediator of RNA polymerase II transcription subunit 20;Mediator of RNA polymerase II transcription subunit 17;Mediator of RNA polymerase II transcription subunit 13;Mediator of RNA polymerase II transcription subunit 23;Mediator of RNA polymerase II transcription subunit 16	MED7;MED14;MED24;MED6;ESR1;CCNC;CDK8;EP300;MED21;MED1;NCOA1;MED12;MED10;MED20;MED17;MED13;MED23;MED16	ARC34 CRSP9;ARC150 CRSP2 CXorf4 DRIP150 EXLM1 RGR1 TRAP170;ARC100 CRSP4 DRIP100 KIAA0130 THRAP4 TRAP100;ARC33;ESR NR3A1;None;None;P300;SRB7 SURB7;ARC205 CRSP1 CRSP200 DRIP205 DRIP230 PBP PPARBP PPARGBP RB18A TRAP220 TRIP2;BHLHE74 SRC1;ARC240 CAGH45 HOPA KIAA0192 TNRC11 TRAP230;None;TRFP;ARC77 CRSP6 DRIP77 DRIP80 TRAP80;ARC250 KIAA0593 THRAP1 TRAP240;ARC130 CRSP3 DRIP130 KIAA1216 SUR2;DRIP92 THRAP5
7582	ESR2-TRAP/Mediator coactivator complex	Human	ESRB-TRAP/Mediator complex	HeLa nuclear cell extract	O43513;O60244;O75448;O75586;P24863;P49336;Q09472;Q13503;Q15648;Q15788;Q92731;Q93074;Q9BTT4;Q9H944;Q9NVC6;Q9UHV7;Q9ULK4;Q9Y2X0	9443;9282;9862;10001;892;1024;2033;9412;5469;8648;2100;9968;84246;9477;9440;9969;9439;10025	MI:0047-far western blotting;MI:0096-pull down	GO:0016592;GO:0009299;GO:0005634;GO:0006355	mediator complex;mRNA transcription;nucleus;regulation of DNA-templated transcription	11.02.03;70.10;11.02.03.04	mRNA synthesis;nucleus;transcriptional control	11867769	The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro. All TRAP/Mediator components examined (with exception of TRAP150) were found to associate with ERalpha and ERbeta LBDs (C-terminal ligand binding domains) in an E2-dependent manner. The assays also show ligand-dependent interactions of SRC-1 and p300 with ER LBDs. These interactions are stronger for ERalpha than for ERbeta. No interactions of general transcription factors TFIIE (IIEalpha) and TFIIF (RAP30) were observed.	None	Gene name synonyms are MED7/CRSP33.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mediator of RNA polymerase II transcription subunit 7;Mediator of RNA polymerase II transcription subunit 14;Mediator of RNA polymerase II transcription subunit 24;Mediator of RNA polymerase II transcription subunit 6;Cyclin-C;Cyclin-dependent kinase 8;Histone acetyltransferase p300;Mediator of RNA polymerase II transcription subunit 21;Mediator of RNA polymerase II transcription subunit 1;Nuclear receptor coactivator 1;Estrogen receptor beta;Mediator of RNA polymerase II transcription subunit 12;Mediator of RNA polymerase II transcription subunit 10;Mediator of RNA polymerase II transcription subunit 20;Mediator of RNA polymerase II transcription subunit 17;Mediator of RNA polymerase II transcription subunit 13;Mediator of RNA polymerase II transcription subunit 23;Mediator of RNA polymerase II transcription subunit 16	MED7;MED14;MED24;MED6;CCNC;CDK8;EP300;MED21;MED1;NCOA1;ESR2;MED12;MED10;MED20;MED17;MED13;MED23;MED16	ARC34 CRSP9;ARC150 CRSP2 CXorf4 DRIP150 EXLM1 RGR1 TRAP170;ARC100 CRSP4 DRIP100 KIAA0130 THRAP4 TRAP100;ARC33;None;None;P300;SRB7 SURB7;ARC205 CRSP1 CRSP200 DRIP205 DRIP230 PBP PPARBP PPARGBP RB18A TRAP220 TRIP2;BHLHE74 SRC1;ESTRB NR3A2;ARC240 CAGH45 HOPA KIAA0192 TNRC11 TRAP230;None;TRFP;ARC77 CRSP6 DRIP77 DRIP80 TRAP80;ARC250 KIAA0593 THRAP1 TRAP240;ARC130 CRSP3 DRIP130 KIAA1216 SUR2;DRIP92 THRAP5
7583	CDK8 subcomplex (CCNC, CDK8, MED12, MED13)	Human	None	HeLa nuclear extract	P24863;P49336;Q93074;Q9UHV7	892;1024;9968;9969	MI:0019-coimmunoprecipitation;MI:0040-electron microscopy;MI:0069-mass spectrometry studies of complexes;MI:0413-electrophoretic mobility shift assay	GO:0035173	histone kinase activity	None	None	19047373	The human CDK8 subcomplex consisting of four proteins (CDK8, Cyclin C, Med12, and Med13) is a histone kinase that requires Med12 for activity and can function independently of Mediator. Med12, but not Med13, is essential for activating the CDK8 kinase.	None	1:1:1:1 stoichiometry was established for the CDK8 subcomplex based upon densitometry measurements	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cyclin-C;Cyclin-dependent kinase 8;Mediator of RNA polymerase II transcription subunit 12;Mediator of RNA polymerase II transcription subunit 13	CCNC;CDK8;MED12;MED13	None;None;ARC240 CAGH45 HOPA KIAA0192 TNRC11 TRAP230;ARC250 KIAA0593 THRAP1 TRAP240
7584	CDK8 subcomplex (CCNC, CDK8, MED12)	Human	None	HeLa nuclear extract	P24863;P49336;Q93074	892;1024;9968	MI:0046-experimental knowledge based	GO:0035173	histone kinase activity	None	None	19047373	The human CDK8 subcomplex consisting of four proteins (CDK8, Cyclin C, Med12, and Med13) is a histone kinase that requires Med12 for activity and can function independently of Mediator. Med12, but not Med13, is essential for activating the CDK8 kinase. Med12 and Med13 each also independently interact with the CDK8/Cyclin-C pair.	None	1:1:1 stoichiometry was established for the CDK8 subcomplex based upon densitometry measurements	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cyclin-C;Cyclin-dependent kinase 8;Mediator of RNA polymerase II transcription subunit 12	CCNC;CDK8;MED12	None;None;ARC240 CAGH45 HOPA KIAA0192 TNRC11 TRAP230
7585	CDK8 subcomplex (CCNC, CDK8, MED13)	Human	None	HeLa nuclear extract	P24863;P49336;Q9UHV7	892;1024;9969	MI:0046-experimental knowledge based	GO:0035173	histone kinase activity	None	None	19047373	The human CDK8 subcomplex consisting of four proteins (CDK8, Cyclin C, Med12, and Med13) is a histone kinase that requires Med12 for activity and can function independently of Mediator. Med12, but not Med13, is essential for activating the CDK8 kinase. Med12 and Med13 each also independently interact with the CDK8/Cyclin-C pair.	None	1:1:1 stoichiometry was established for the CDK8 subcomplex based upon densitometry measurements	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cyclin-C;Cyclin-dependent kinase 8;Mediator of RNA polymerase II transcription subunit 13	CCNC;CDK8;MED13	None;None;ARC250 KIAA0593 THRAP1 TRAP240
7586	FOXO1-ESR1 complex	Human	FKHR-ESRA complex	human hepatocyte carcinoma HepG2 cells; MCF-7 human breast tumor	P03372;Q12778	2099;2308	MI:0018-two hybrid;MI:0096-pull down	GO:0030331;GO:0016922	nuclear estrogen receptor binding;nuclear receptor binding	None	None	11353774	FKHR interacts with ERalpha in an E2-dependent fashion and represses ER-mediated transactivation.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Estrogen receptor;Forkhead box protein O1	ESR1;FOXO1	ESR NR3A1;FKHR FOXO1A
7587	APP(AICD)-FOXO3 complex	Human	APP(AICD)-FOXO3a complex	HEK 293T cells; SY-SH5Y cells	O43524;P05067	2309;351	MI:0019-coimmunoprecipitation	GO:0005737;GO:0008219;GO:0006979;GO:0005634;GO:0006915	cytoplasm;cell death;response to oxidative stress;nucleus;apoptotic process	70.03;40.10;32.01.01;70.10;40.10.02	cytoplasm;cell death;oxidative stress response;nucleus;apoptosis (type I programmed cell death)	24832605	In human cells, AICD physically interacts with FoxO1, FoxO3a, or FoxO4 in HEK 293T cells in the cytoplasm, translocates with Foxo3a into the nucleus upon oxidative stress, and promotes FoxO-induced transcription of pro-apoptotic gene Bim. Data demonstrate that APP modulates FoxO-mediated cell death through AICD, which acts as a transcriptional co-activator of FoxO.	None	AICD is a small APP intracellular domain.	Homo sapiens (Human);Homo sapiens (Human)	Forkhead box protein O3;Amyloid-beta precursor protein	FOXO3;APP	FKHRL1, FOXO3A;A4 AD1
7588	APP(AICD)-FOXO1 complex	Human	None	HEK 293T cells; SY-SH5Y cells	P05067;Q12778	351;2308	MI:0019-coimmunoprecipitation	GO:0008219;GO:0005737;GO:0006915	cell death;cytoplasm;apoptotic process	40.10;70.03;40.10.02	cell death;cytoplasm;apoptosis (type I programmed cell death)	24832605	In human cells, AICD physically interacts with FoxO1, FoxO3a, or FoxO4 in HEK 293T cells in the cytoplasm, translocates with Foxo3a into the nucleus upon oxidative stress, and promotes FoxO-induced transcription of pro-apoptotic gene Bim. Data demonstrate that APP modulates FoxO-mediated cell death through AICD, which acts as a transcriptional co-activator of FoxO.	None	AICD is a small APP intracellular domain.	Homo sapiens (Human);Homo sapiens (Human)	Amyloid-beta precursor protein;Forkhead box protein O1	APP;FOXO1	A4 AD1;FKHR FOXO1A
7589	APP(AICD)-FOXO4 complex	Human	None	HEK 293T cells; SY-SH5Y cells	P05067;P98177	351;4303	MI:0019-coimmunoprecipitation	GO:0008219;GO:0005737;GO:0006915	cell death;cytoplasm;apoptotic process	40.10;70.03;40.10.02	cell death;cytoplasm;apoptosis (type I programmed cell death)	24832605	In human cells, AICD physically interacts with FoxO1, FoxO3a, or FoxO4 in HEK 293T cells in the cytoplasm, translocates with Foxo3a into the nucleus upon oxidative stress, and promotes FoxO-induced transcription of pro-apoptotic gene Bim. Data demonstrate that APP modulates FoxO-mediated cell death through AICD, which acts as a transcriptional co-activator of FoxO.	None	AICD is a small APP intracellular domain.	Homo sapiens (Human);Homo sapiens (Human)	Amyloid-beta precursor protein;Forkhead box protein O4	APP;FOXO4	A4 AD1;AFX AFX1 MLLT7
7590	CASP2(S isoform)-SPTAN1 complex	Human	CASP-2S-fodrin complex	HeLa cells, CDDP cells	P42575-2;Q13813	835;6709	MI:0019-coimmunoprecipitation;MI:0069-mass spectrometry studies of complexes;MI:0096-pull down	GO:0043066;GO:1904171	negative regulation of apoptotic process;negative regulation of bleb assembly	40.10.02.01	anti-apoptosis	23840868	CASP-2S-fodrin complex formation inhibits DNA damage-induced cytoplasmic fodrin cleavage and prevents the membrane blebbing and phosphatidylserine externalization that are characteristics of apoptosis in cancer cells.	None	CASP-2S (P42575-2) is a splice variant of CASP2.The long isoform CASP-2L (P42575-1) does not interact with fodrin (PMID:23840868).	Homo sapiens (Human);Homo sapiens (Human)	Isoform 2 of Caspase-2;Spectrin alpha chain, non-erythrocytic 1	CASP2;SPTAN1	ICH1 NEDD2;NEAS SPTA2
7591	Del133-p53beta-RHOB complex	Human	None	None	P04637-8;P62745	7157;388	MI:0019-coimmunoprecipitation	GO:0043066	negative regulation of apoptotic process	40.10.02.01	anti-apoptosis	28212429	delta133p53\u00df inhibits RhoB tumor suppressor activity, thereby protecting tumor cells from RhoB-induced apoptosis (PMID:28212429).	None	Del133-p53beta is a splice variant of TP53.	Homo sapiens (Human);Homo sapiens (Human)	Isoform 8 of Cellular tumor antigen p53;Rho-related GTP-binding protein RhoB	TP53;RHOB	P53;ARH6,ARHB
7593	AKAP13-MAP2K3-MAP3K20-MAPK14-PKN1 complex	Human	None	HEK293 cells	P46734;Q12802;Q16512;Q16539;Q9NYL2	5606;11214;5585;1432;51776	MI:0019-coimmunoprecipitation	GO:0000165	MAPK cascade	30.01.05.01.03	MAPKKK cascade	21224381	Silencing of AKAP13 expression  specifically reduces alpha1-adrenergic-receptor-mediated MAPK14 (p38alpha) activation without affecting receptor-mediated activation of other MAPK pathways.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Dual specificity mitogen-activated protein kinase kinase 3;A-kinase anchor protein 13;Serine/threonine-protein kinase N1;Mitogen-activated protein kinase 14;Mitogen-activated protein kinase kinase kinase 20	MAP2K3;AKAP13;PKN1;MAPK14;MAP3K20	MEK3 MKK3 PRKMK3 SKK2;BRX HT31 LBC;PAK1 PKN PRK1 PRKCL1;CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A;MLTK ZAK
7595	NARC1 complex	Human	None	HCT116 cells	P11387;P38159;Q86V81;Q99459;Q9UMS4	7150;27316;10189;988;27339	MI:0019-coimmunoprecipitation;MI:0071-molecular sieving	GO:0031297;GO:0010564;GO:0005634	replication fork processing;regulation of cell cycle process;nucleus	70.10	nucleus	30150775	The lncRNA NORAD (non-coding RNA activated by DNA damage) interacts with proteins forming a topoisomerase complex. The NARC1 complex localizes to the nucleus upon stimulation with replication stress or DNA damage. Cells lacking the NARC1 complex activity display an increased frequency of chromosome segregation defects, reduced replication-fork velocity and altered cell-cycle progression.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA topoisomerase 1;RNA-binding motif protein, X chromosome;THO complex subunit 4;Cell division cycle 5-like protein;Pre-mRNA-processing factor 19	TOP1;RBMX;ALYREF;CDC5L;PRPF19	None;HNRPG RBMXP1;ALY BEF THOC4;KIAA0432 PCDC5RP;NMP200 PRP19 SNEV
7596	tRNA splicing ligase	Human	C14orf166-C2orf49-DDX1-FAM98B-RTCB-ZBTB8OS complex	HEK293 cells	Q52LJ0;Q8IWT0;Q92499;Q9BVC5;Q9Y224;Q9Y3I0	283742;339487;1653;79074;51637;51493	MI:0007-anti tag coimmunoprecipitation	GO:0000394;GO:0072669	RNA splicing, via endonucleolytic cleavage and ligation;tRNA-splicing ligase complex	None	None	24870230	ZBTB8OS (ARCH), a protein of previously unknown function, is required for full activity of the human tRNA ligase complex and, in cooperation with DDX1, facilitates the formation of an RTCB\u2013guanylate intermediate central to mammalian RNA ligation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein FAM98B;Protein archease;ATP-dependent RNA helicase DDX1;Ashwin;RNA transcription, translation and transport factor protein;RNA-splicing ligase RtcB homolog	FAM98B;ZBTB8OS;DDX1;C2orf49;RTRAF;RTCB	None;ARCH;None;None;C14orf166;C22orf28
7597	CTNNB1-RUNX3-TCF4 complex	Human	None	HCT116 cells, HEK293 cells, SW620 cells	P15884;P35222;Q13761	6925;1499;864	MI:0007-anti tag coimmunoprecipitation	GO:0030178;GO:0045892;GO:0005634	negative regulation of Wnt signaling pathway;negative regulation of DNA-templated transcription;nucleus	11.02.03.04.03;70.10	transcription repression;nucleus	18772112	None	RUNX3 activity is frequently downregulated in human colorectal cancer.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transcription factor 4;Catenin beta-1;Runt-related transcription factor 3	TCF4;CTNNB1;RUNX3	BHLHB19 ITF2 SEF2;CTNNB;AML2 CBFA3 PEBP2A3
7598	ESR1-VDAC1 complex	Human	None	cortical and hippocampal areas	P03372;P21796	2099;7416	MI:0019-coimmunoprecipitation	GO:0005886;GO:0008308	plasma membrane;voltage-gated anion channel activity	70.02	eukaryotic plasma membrane / membrane attached	19595769	Voltage-dependent anion channel (VDAC) is a mitochondrial porin also found in the neuronal membrane (pl-VDAC), where its function may be related to redox homeostasis and apoptosis. In Alzheimer's disease (AD) brains, VDAC was accumulated in caveolae, and it was observed in dystrophic neurites of senile plaques, whereas ERalpha was expressed in astrocytes surrounding the plaques. The co-precipitation of VDAC and 67 kDa-ERalpha in temporal cortex and hippocampus was shown. pl-VDAC and mERalpha also form a complex with scaffolding caveolin-1 which likely provides mERalpha stability at the plasma membrane (compare CORUM:5862).	The VDAC and ERalpha interaction in caveolae from human cortex is altered in Alzheimer's disease.	None	Homo sapiens (Human);Homo sapiens (Human)	Estrogen receptor;Voltage-dependent anion-selective channel protein 1	ESR1;VDAC1	ESR NR3A1;VDAC
7604	Creb1-Crebbp-Rbbp4 complex	Human	Creb1-Crebbp-RbAp48 complex	embryo library	P45481;Q01147;Q60972	12914;12912;19646	MI:0397-two hybrid array	None	None	None	None	10866654	None	None	None	Mus musculus (Mouse);Mus musculus (Mouse);Mus musculus (Mouse)	Histone lysine acetyltransferase CREBBP;Cyclic AMP-responsive element-binding protein 1;Histone-binding protein RBBP4	Crebbp;Creb1;Rbbp4	Cbp;Creb-1;Rbap48
7607	AJUBA-LATS2 complex	Human	LATS2-AJUBA complex	HeLa cells	Q96IF1;Q9NRM7	84962;26524	MI:0007-anti tag coimmunoprecipitation	GO:0005813;GO:0007051	centrosome;spindle organization	70.05	centrosome	16413547	The complex LATS2-AJUBA regulates spindle organization through recruitment of ??tubulin to centrosomes.	None	None	Homo sapiens (Human);Homo sapiens (Human)	LIM domain-containing protein ajuba;Serine/threonine-protein kinase LATS2	AJUBA;LATS2	JUB;KPM
7609	ADA-ADORA2A-DPP4 complex	Human	None	in vitro	P00813;P27487;P29274	100;1803;135	MI:0051-fluorescence technology	GO:0043063;GO:0098609	intercellular bridge organization;cell-cell adhesion	None	None	29497379	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Adenosine deaminase;Dipeptidyl peptidase 4;Adenosine receptor A2a	ADA;DPP4;ADORA2A	ADA1;ADCP2 CD26;ADORA2
7612	LIM protein complex LHX3-TGFB1I1-ISL1	Human	None	HEK293T cells	O43294;P61371;Q9UBR4	7041;3670;8022	MI:0006-anti bait coimmunoprecipitation	GO:0007601	visual perception	34.11.01.03	visual transduction	28139974	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transforming growth factor beta-1-induced transcript 1 protein;Insulin gene enhancer protein ISL-1;LIM/homeobox protein Lhx3	TGFB1I1;ISL1;LHX3	ARA55;None;None
7613	MN-hexamer complex	Human	Motor neuron-hexamer complex	HEK293T cells	P40763;P61371;Q9UBR4	6774;3670;8022	MI:0007-anti tag coimmunoprecipitation	GO:0021522;GO:0045944	spinal cord motor neuron differentiation;positive regulation of transcription by RNA polymerase II	None	None	23798382	STAT3 associates with the MN\u2013hexamer and enhances the MN\u2013hexamer\u2013directed transcription.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Signal transducer and activator of transcription 3;Insulin gene enhancer protein ISL-1;LIM/homeobox protein Lhx3	STAT3;ISL1;LHX3	APRF;None;None
7614	PHD2-LIMD1-VHL complex	Human	None	HEK293 cells	P40337;Q9GZT9;Q9UGP4	7428;54583;8994	MI:0019-coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:1902071	regulation of hypoxia-inducible factor-1alpha signaling pathway	None	None	22286099	The PHD-LIMD1-VHL protein complex enables efficient degradation of HIF-1alpha.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	von Hippel-Lindau disease tumor suppressor;Egl nine homolog 1;LIM domain-containing protein 1	VHL;EGLN1;LIMD1	None;C1orf12;None
7617	LIM kinase-slingshot phosphatase complex	Human	SSH1-14-3-3zeta-LIMK1 complex; SSH1-YWHAZ-LIMK1 complex;	HEK293 cells	P53667;P63104;Q8WYL5	None;7534;54434	MI:0007-anti tag coimmunoprecipitation;MI:0096-pull down	GO:0030036	actin cytoskeleton organization	42.04.03	actin cytoskeleton	15660133	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	LIM domain kinase 1;14-3-3 protein zeta/delta;Protein phosphatase Slingshot homolog 1	LIMK1;YWHAZ;SSH1	LIMK;None;KIAA1298,SSH1L
7620	YAP-PRDM4 transcription factor complex	Human	None	HEK293 cells	P46937;Q9UKN5	10413;11108	MI:0019-coimmunoprecipitation	GO:0035329;GO:0033622	hippo signaling;integrin activation	None	None	29669796	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Transcriptional coactivator YAP1;PR domain zinc finger protein 4	YAP1;PRDM4	YAP65;PFM1
7621	HSF1-IER5-PP2A complex	Human	None	HEK293T cells	P63151;P67775;Q00613;Q5VY09	5520;5515;3297;51278	MI:0007-anti tag coimmunoprecipitation;MI:0416-fluorescence microscopy	GO:0006470	protein dephosphorylation	14.07.03	modification by phosphorylation, dephosphorylation, autophosphorylation	26754925	IER5 forms a ternary complex with HSF1 and PP2A to dephosphorylate and activate HSF1.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform;Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform;Heat shock factor protein 1;Immediate early response gene 5 protein	PPP2R2A;PPP2CA;HSF1;IER5	None;None;HSTF1;None
7622	HSF1\u2013PARP1\u2013PARP13 complex	Human	HSF1\u2013PARP13\u2013PARP1 complex	HeLa cells	P09874;Q00613;Q7Z2W4	142;3297;56829	MI:0007-anti tag coimmunoprecipitation	GO:0006281;GO:0005634;GO:0010628	DNA repair;nucleus;positive regulation of gene expression	10.01.05.01;70.10	DNA repair;nucleus	29158484	HSF1\u2013PARP13\u2013PARP1 enhances gene expression upon DNA damage.	Experiments indicate that the HSF1\u2013PARP1\u2013PARP13 complex specifically supports growth of BRCA1-deficient mammary tumors partly by facilitating DNA repair.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Poly [ADP-ribose] polymerase 1;Heat shock factor protein 1;Zinc finger CCCH-type antiviral protein 1	PARP1;HSF1;ZC3HAV1	ADPRT PPOL;HSTF1;ZC3HDC2
7623	HSPA8-HSPBP1-STUB1 complex	Human	CHIP-HSC70-HSPBP1 complex	HeLa cells	P11142;Q9NZL4;Q9UNE7	3312;23640;10273	MI:0007-anti tag coimmunoprecipitation	GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process	None	None	15215316	The cochaperone STUB1 (CHIP) is able to switch chaperone activity from protein folding to protein degradation by virtue of its ubiquitin ligase activity. Complex formation between HspBP1, HSPA8 (Hsc70) and STUB1 is necessary for HspBP1 to exert its STUB1-inhibiting activity.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Heat shock cognate 71 kDa protein;Hsp70-binding protein 1;E3 ubiquitin-protein ligase CHIP	HSPA8;HSPBP1;STUB1	HSC70 HSP73 HSPA10;HSPBP;CHIP
7624	BAG1-HSPA8-STUB1 complex	Human	BAG1-CHIP-HSC70 complex	HeLa cells	P11142;Q99933;Q9UNE7	3312;573;10273	MI:0007-anti tag coimmunoprecipitation	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	14.13.01.01	proteasomal degradation (ubiquitin/proteasomal pathway)	11676916	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Heat shock cognate 71 kDa protein;BAG family molecular chaperone regulator 1;E3 ubiquitin-protein ligase CHIP	HSPA8;BAG1;STUB1	HSC70 HSP73 HSPA10;HAP;CHIP
7625	IFI1-IFI2-IFI3 complex	Human	None	HeLa cells	O14879;P09913;P09914	3437;3433;3434	MI:0007-anti tag coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0006915;GO:0005737	apoptotic process;cytoplasm	40.10.02;70.03	apoptosis (type I programmed cell death);cytoplasm	21190939	IFI1, IFI2, and IFI3 exist as 150 \u2013200-kDa complexes in the cytoplasm.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Interferon-induced protein with tetratricopeptide repeats 3;Interferon-induced protein with tetratricopeptide repeats 2;Interferon-induced protein with tetratricopeptide repeats 1	IFIT3;IFIT2;IFIT1	CIG-49 IFI60 IFIT4 ISG60;CIG-42 G10P2 IFI54 ISG54;G10P1 IFI56 IFNAI1 ISG56
7626	CSDE1-IGF2BP1-PABPC1 complex	Human	UNR-IMP1-PABP complex	None	O75534;P11940;Q9NZI8	7812;26986;10642	MI:0007-anti tag coimmunoprecipitation;MI:0400-affinity technology;MI:0430-nucleic acid uv cross-linking assay	GO:0017148;GO:0005737	negative regulation of translation;cytoplasm	70.03	cytoplasm	16356927	The adenine-rich autoregulatory sequence (ARS)  interacts with CSDE1, IGF2BP1 and PABPC1 to form a heteromeric RNP complex that represses PABP mRNA translation under physiological conditions.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cold shock domain-containing protein E1;Polyadenylate-binding protein 1;Insulin-like growth factor 2 mRNA-binding protein 1	CSDE1;PABPC1;IGF2BP1	D1S155E KIAA0885 NRU UNR;PAB1 PABP PABP1 PABPC2;CRDBP VICKZ1 ZBP1
7627	H2A.Z histone-exchange complex p400/TIP60	Human	None	HeLa cells	O43257;O95619;O96019;P0C0S5;P12956;P13010;P62805;P62807;P68431;P78527;Q15014;Q15906;Q52LR7;Q6ZRS2;Q92993;Q96L91;Q96P70;Q9BTT0;Q9H0E9;Q9H2F5;Q9NPF5;Q9NV56;Q9NXR8;Q9UBU8;Q9Y230;Q9Y265;Q9Y4A5	10467;8089;86;3015;2547;7520;None;3017;None;5591;9643;6944;26122;10847;10524;57634;55705;81611;10902;80314;55929;55257;54556;10933;10856;8607;8295	MI:0007-anti tag coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0003677;GO:0043486	DNA binding;histone exchange	16.03.01	DNA binding	24463511	None	None	HeLa cell lines expressed H2A.Z (e-H2A.Z) histones fused to amino (N)-terminal double haemagglutinin (HA) and Flag tags.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Zinc finger HIT domain-containing protein 1;YEATS domain-containing protein 4;Actin-like protein 6A;Histone H2A.Z;X-ray repair cross-complementing protein 6;X-ray repair cross-complementing protein 5;Histone H4;Histone H2B type 1-C/E/F/G/I;Histone H3.1;DNA-dependent protein kinase catalytic subunit;Mortality factor 4-like protein 2;Vacuolar protein sorting-associated protein 72 homolog;Enhancer of polycomb homolog 2;Helicase SRCAP;Histone acetyltransferase KAT5;E1A-binding protein p400;Importin-9;Acidic leucine-rich nuclear phosphoprotein 32 family member E;Bromodomain-containing protein 8;Enhancer of polycomb homolog 1;DNA methyltransferase 1-associated protein 1;MRG/MORF4L-binding protein;Inhibitor of growth protein 3;Mortality factor 4-like protein 1;RuvB-like 2;RuvB-like 1;Transformation/transcription domain-associated protein	ZNHIT1;YEATS4;ACTL6A;H2AZ1;XRCC6;XRCC5;H4C1;H2BC4;H3C1;PRKDC;MORF4L2;VPS72;EPC2;SRCAP;KAT5;EP400;IPO9;ANP32E;BRD8;EPC1;DMAP1;MRGBP;ING3;MORF4L1;RUVBL2;RUVBL1;TRRAP	CGBP1 ZNFN4A1;GAS41;BAF53 BAF53A INO80K;H2AFZ H2AZ;G22P1;G22P2;H4/A H4FA HIST1H4A;H2BFL,HIST1H2BC;H3FA,HIST1H3A;HYRC HYRC1;KIAA0026 MRGX;TCFL1 YL1;None;KIAA0309;HTATIP, TIP60;CAGH32 KIAA1498 KIAA1818 TNRC12;IMP9 KIAA1192 RANBP9;None;SMAP, SMAP2;None;KIAA1425;C20orf20;None;MRG15;INO80J TIP48 TIP49B;INO80H NMP238 TIP49 TIP49A;PAF400
7631	INSIG1-RNF139 complex	Human	None	TRC8-HA-FlPln cells (HEK293)	O15503;Q8WU17	3638;11236	MI:0007-anti tag coimmunoprecipitation	GO:0017148;GO:0016567;GO:0055088	negative regulation of translation;protein ubiquitination;lipid homeostasis	14.07.05	modification by ubiquitination, deubiquitination	20068067	INSIG-1 physically interacts with TRC8, and TRC8 enhances ubiquitylation of INSIG-1 in a RING-dependent manner. Polyubiquitylation of TRC8 itself was observed and this increased with added sterols. Reduction of SREBP target gene expression demonstrated that induced TRC8 inhibits these transcription factors. Results suggest that TRC8 is positioned to coordinate lipid homeostasis and protein translation during extended periods of cholesterol limitation.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Insulin-induced gene 1 protein;E3 ubiquitin-protein ligase RNF139	INSIG1;RNF139	None;TRC8
7637	HTR3A-HTR3B complex	Human	None	HEK293 cells	O95264;P46098	9177;3359	MI:0096-pull down;MI:0416-fluorescence microscopy	GO:0099056;GO:0007210	integral component of presynaptic membrane;serotonin receptor signaling pathway	30.05.02.24.01	serotonin receptor signalling pathway	17392525	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	5-hydroxytryptamine receptor 3B;5-hydroxytryptamine receptor 3A	HTR3B;HTR3A	None;5HT3R HTR3
7638	HTR3A-HTR3C complex	Human	None	HEK293 cells	P46098;Q8WXA8	3359;170572	MI:0096-pull down;MI:0416-fluorescence microscopy	GO:0099056;GO:0007210	integral component of presynaptic membrane;serotonin receptor signaling pathway	30.05.02.24.01	serotonin receptor signalling pathway	17392525	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	5-hydroxytryptamine receptor 3A;5-hydroxytryptamine receptor 3C	HTR3A;HTR3C	5HT3R HTR3;None
7639	HTR3A-HTR3D complex	Human	None	HEL293 cells	P46098;Q70Z44	3359;200909	MI:0096-pull down;MI:0416-fluorescence microscopy	GO:0099056;GO:0007210	integral component of presynaptic membrane;serotonin receptor signaling pathway	30.05.02.24.01	serotonin receptor signalling pathway	17392525	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	5-hydroxytryptamine receptor 3A;5-hydroxytryptamine receptor 3D	HTR3A;HTR3D	5HT3R HTR3;None
7640	HTR3A-HTR3E complex	Human	None	HEK293 cells	A5X5Y0;P46098	285242;3359	MI:0096-pull down;MI:0416-fluorescence microscopy	GO:0099056;GO:0007210	integral component of presynaptic membrane;serotonin receptor signaling pathway	30.05.02.24.01	serotonin receptor signalling pathway	17392525	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	5-hydroxytryptamine receptor 3E;5-hydroxytryptamine receptor 3A	HTR3E;HTR3A	None;5HT3R HTR3
7645	ADGRA2-DOCK1-ELMO2-GNB1-GNG2 complex	Human	None	HEK293T cells	P59768;P62873;Q14185;Q96JJ3;Q96PE1	54331;2782;1793;63916;25960	MI:0007-anti tag coimmunoprecipitation	GO:0007155	cell adhesion	34.07	cell adhesion	28600358	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;Dedicator of cytokinesis protein 1;Engulfment and cell motility protein 2;Adhesion G protein-coupled receptor A2	GNG2;GNB1;DOCK1;ELMO2;ADGRA2	None;None;None;CED12A KIAA1834;GPR124,KIAA1531,TEM5
7650	CAMK4-HSPA1L-HSPA8-IQCG complex	Human	None	HEK293 cells	P11142;P34931;Q16566;Q9H095	3312;3305;814;84223	MI:0007-anti tag coimmunoprecipitation	GO:0019722;GO:0030097	calcium-mediated signaling;hemopoiesis	30.01.09.03;41.05.18	Ca2+ mediated signal transduction;hemopoiesis	24787902	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Heat shock cognate 71 kDa protein;Heat shock 70 kDa protein 1-like;Calcium/calmodulin-dependent protein kinase type IV;Dynein regulatory complex protein 9	HSPA8;HSPA1L;CAMK4;IQCG	HSC70 HSP73 HSPA10;None;CAMK CAMK-GR CAMKIV;DRC9
7651	IRAK1-IRAK4-MYD88-PELI1-TRAF6 complex	Human	None	HEK293 cells	P51617;Q96FA3;Q99836;Q9NWZ3;Q9Y4K3	3654;57162;4615;51135;7189	MI:0096-pull down	None	None	None	None	16951688	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Interleukin-1 receptor-associated kinase 1;E3 ubiquitin-protein ligase pellino homolog 1;Myeloid differentiation primary response protein MyD88;Interleukin-1 receptor-associated kinase 4;TNF receptor-associated factor 6	IRAK1;PELI1;MYD88;IRAK4;TRAF6	IRAK;PRISM;None;None;RNF85
7652	IRAK2-IRAK4-MYD88 complex	Human	MyD88-IRAK4-IRAK2 complex; Myddosome-IRAK2 complex	in vitro	O43187;Q99836;Q9NWZ3	3656;4615;51135	MI:0114-x-ray crystallography;MI:0071-molecular sieving	GO:0002224;GO:0045087;GO:0002221;GO:0051092;GO:0006954;GO:0006952;GO:0002755	toll-like receptor signaling pathway;innate immune response;pattern recognition receptor signaling pathway;positive regulation of NF-kappaB transcription factor activity;inflammatory response;defense response;MyD88-dependent toll-like receptor signaling pathway	36.25.16.01;36.25.16.07	innate immune response (invertebrates and vertebrates);inflammatory response	20485341	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Interleukin-1 receptor-associated kinase-like 2;Myeloid differentiation primary response protein MyD88;Interleukin-1 receptor-associated kinase 4	IRAK2;MYD88;IRAK4	None;None;None
7655	CAPN7-CHMP1B-IST1 complex	Human	None	HEK293T cells	P53990;Q7LBR1;Q9Y6W3	9798;57132;23473	MI:0007-anti tag coimmunoprecipitation	None	None	None	None	21616915	None	None	Co-immunoprecipitation assays demonstrated that the interaction between CAPN7 and CHMP1B and between CAPN7 and IST1 became stronger when IST1 or CHMP1B was additionally coexpressed.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	IST1 homolog;Charged multivesicular body protein 1b;Calpain-7	IST1;CHMP1B;CAPN7	KIAA0174;C18orf2;PALBH
7656	ISY1-PRPF19-XAB2 complex	Human	None	U2OS cells	Q9HCS7;Q9ULR0;Q9UMS4	56949;57461;27339	MI:0007-anti tag coimmunoprecipitation	GO:0035061;GO:0035825	interchromatin granule;homologous recombination	None	None	27084940	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Pre-mRNA-splicing factor SYF1;Pre-mRNA-splicing factor ISY1 homolog;Pre-mRNA-processing factor 19	XAB2;ISY1;PRPF19	HCNP KIAA1177 SYF1;KIAA1160;NMP200 PRP19 SNEV
7657	AQR-ISY1-PPIE-PRPF19-XAB2-ZNF830 complex	Human	None	HeLa cells	O60306;Q96NB3;Q9HCS7;Q9ULR0;Q9UMS4;Q9UNP9	9716;91603;56949;57461;27339;10450	MI:0007-anti tag coimmunoprecipitation;MI:0071-molecular sieving;MI:0226-ion exchange chromatography	GO:0000398;GO:0009299;GO:0006283;GO:0005634	mRNA splicing, via spliceosome;mRNA transcription;transcription-coupled nucleotide-excision repair;nucleus	11.04.03;11.02.03;70.10	mRNA processing (splicing, 5'-, 3'-end processing);mRNA synthesis;nucleus	17981804	During gel filtration analysis the protein complex was included in the 0.5-MDa fraction.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	RNA helicase aquarius;Zinc finger protein 830;Pre-mRNA-splicing factor SYF1;Pre-mRNA-splicing factor ISY1 homolog;Pre-mRNA-processing factor 19;Peptidyl-prolyl cis-trans isomerase E	AQR;ZNF830;XAB2;ISY1;PRPF19;PPIE	KIAA0560;CCDC16;HCNP KIAA1177 SYF1;KIAA1160;NMP200 PRP19 SNEV;CYP33
7658	ITCH-MAVS-PCBP2 complex	Human	AIP4-PCBP2-MAVS complex	HEK 293 cells	Q15366;Q7Z434;Q96J02	5094;57506;83737	MI:0007-anti tag coimmunoprecipitation	GO:0043161;GO:0051607;GO:0045087;GO:0039536;GO:0002221	proteasome-mediated ubiquitin-dependent protein catabolic process;defense response to virus;innate immune response;negative regulation of RIG-I signaling pathway;pattern recognition receptor signaling pathway	14.13.01.01;36.25.16.01	proteasomal degradation (ubiquitin/proteasomal pathway);innate immune response (invertebrates and vertebrates)	19881509	This complex terminates antiviral RIG-I signalling. PCBP2 functions as an adaptor between MAVS and AIP4. Upon viral infection, PCBP2 interacts with MAVS and recruits the E3 ligase AIP4 to the complex, to catalyze K48-linked polyubiquitination and degradation of MAVS to fine-tune antiviral response.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Poly(rC)-binding protein 2;Mitochondrial antiviral-signaling protein;E3 ubiquitin-protein ligase Itchy homolog	PCBP2;MAVS;ITCH	None;IPS1,KIAA1271,VISA;None
7659	ITCH-MAP3K7-NDFIP1 complex	Human	None	HEK293 cells	O43318;Q96J02;Q9BT67	6885;83737;80762	MI:0007-anti tag coimmunoprecipitation	GO:0006954	inflammatory response	36.25.16.07	inflammatory response	25632008	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mitogen-activated protein kinase kinase kinase 7;E3 ubiquitin-protein ligase Itchy homolog;NEDD4 family-interacting protein 1	MAP3K7;ITCH;NDFIP1	TAK1;None;N4WBP5
7661	CD17-ITGAM-ITGB2 complex	Human	None	Neutrophils	P05107;P11215;Q8N6Q3	3689;3684;57126	MI:0107-surface plasmon resonance;MI:0663-confocal microscopy	GO:0042119;GO:0045121	neutrophil activation;membrane raft	None	None	21193407	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-2;Integrin alpha-M;CD177 antigen	ITGB2;ITGAM;CD177	CD18 MFI7;CD11B CR3A;NB1,PRV1
7662	IZUMO1-IZUMO1R complex	Human	None	Drosophila melanogaster S2 cells	A6ND01;Q8IYV9	390243;284359	MI:0114-x-ray crystallography	GO:0016020;GO:0009566	membrane;fertilization	41.05.01	fertilization	27309818	At least two proteins, sperm IZUMO1 and egg JUNO, are essential for gamete recognition, fusion, or both.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Sperm-egg fusion protein Juno;Izumo sperm-egg fusion protein 1	IZUMO1R;IZUMO1	FOLR4,JUNO;None
7663	HYPK-NAA10-NAA15 complex	Human	None	HEK293 cells, HeLa cells	P41227;Q9BXJ9;Q9NX55	8260;80155;25764	MI:0096-pull down	GO:0005737	cytoplasm	70.03	cytoplasm	20154145	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	N-alpha-acetyltransferase 10;N-alpha-acetyltransferase 15, NatA auxiliary subunit;Huntingtin-interacting protein K	NAA10;NAA15;HYPK	ARD1 ARD1A TE2;GA19 NARG1 NATH TBDN100;C15orf63
7664	EZR-MSN-PAG1-RDX-SLC9A3R1 complex	Human	Cbp-EBP50-ERM complex	Jurkat cells	O14745;P15311;P26038;P35241;Q9NWQ8	9368;7430;4478;5962;55824	MI:0007-anti tag coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0001771;GO:0045121	immunological synapse formation;membrane raft	None	None	11777944	Results suggest that anchoring of lipid raft to the cytoskeleton through EZR-MSN-PAG1-RDX-SLC9A3R1 complex regulates membrane dynamism for synapse formation and T cell activation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Na(+)/H(+) exchange regulatory cofactor NHE-RF1;Ezrin;Moesin;Radixin;Phosphoprotein associated with glycosphingolipid-enriched microdomains 1	SLC9A3R1;EZR;MSN;RDX;PAG1	NHERF NHERF1;VIL2;None;None;CBP,PAG
7665	MAU2-NIPBL complex	Human	None	HeLa cells	Q6KC79;Q9Y6X3	25836;23383	MI:0007-anti tag coimmunoprecipitation	GO:0034088	maintenance of mitotic sister chromatid cohesion	None	None	31753851	In experiments, looping on DNA molecules occurred  only when cohesin and MAU2-NIPBL were introduced simultaneously.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Nipped-B-like protein;MAU2 chromatid cohesion factor homolog	NIPBL;MAU2	IDN3,SCC2;KIAA0892,SCC4
7666	TANK-TBK1-TRAF2 complex	Human	TBK1-TANK-TRAF2 complex	HEK 293 cells	Q12933;Q92844;Q9UHD2	7186;10010;29110	MI:0007-anti tag coimmunoprecipitation	GO:0006954;GO:0051092;GO:0006355;GO:0043123;GO:0045087;GO:0051607;GO:0019048	inflammatory response;positive regulation of NF-kappaB transcription factor activity;regulation of DNA-templated transcription;positive regulation of I-kappaB kinase/NF-kappaB signaling;innate immune response;defense response to virus;modulation by virus of host process	36.25.16.07;11.02.03.04;36.25.16.01	inflammatory response;transcriptional control;innate immune response (invertebrates and vertebrates)	10581243	The TANK-TBK1-TRAF2 signaling complex feeds into the NIK\u2013IKK cascade (PMID:10581243). Analysis of the SARS-CoV-2-host interactome postulates that SARS-CoV-2 ORF6 protein interacts with the TANK-TBK1-TRAF2 complex to modulate both type I IFN and NF-kappaB pathways upon infection, facilitating SARS-CoV-2 to escape from host innate immune surveillance (PMID:32838362).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	TNF receptor-associated factor 2;TRAF family member-associated NF-kappa-B activator;Serine/threonine-protein kinase TBK1	TRAF2;TANK;TBK1	TRAP3;ITRAF TRAF2;NAK
7667	Vps34 Complex I	Human	ATG14-BECN1-NRBF2-PIK3C3-PIC3R4 complex	HEK 293T cells	Q14457;Q6ZNE5;Q8NEB9;Q96F24;Q99570	8678;22863;5289;29982;30849	MI:0007-anti tag coimmunoprecipitation	GO:0016239	positive regulation of macroautophagy	None	None	24785657	It was shown that NRBF2 is a new member of Vps34 Complex I, and regulates the induction of autophagy in response to serum starvation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Beclin-1;Beclin 1-associated autophagy-related key regulator;Phosphatidylinositol 3-kinase catalytic subunit type 3;Nuclear receptor-binding factor 2;Phosphoinositide 3-kinase regulatory subunit 4	BECN1;ATG14;PIK3C3;NRBF2;PIK3R4	GT197;ATG14L KIAA0831;VPS34;COPR;VPS15
7669	MAP3K5-TXN complex	Human	ASK1\u2013TRX Complex	HCT cells	P10599;Q99683	7295;4217	MI:0019-coimmunoprecipitation	None	None	None	None	23319048	Dissociation of the MAP3K5-TXN complex via SCO2 induces MAP3K5-dependent apoptosis in hypoxic tumors.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Thioredoxin;Mitogen-activated protein kinase kinase kinase 5	TXN;MAP3K5	TRDX TRX TRX1;ASK1 MAPKKK5 MEKK5
7670	AKAP1-MAATS1-MYCBP-PRKAR2B complex	Human	AAT1-AMY1-AKAP149-RII-beta complex	HeLa cells	P31323;Q7Z4T9;Q92667;Q99417	5577;89876;8165;26292	MI:0019-coimmunoprecipitation;MI:0416-fluorescence microscopy	None	None	None	None	12223483	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	cAMP-dependent protein kinase type II-beta regulatory subunit;Cilia- and flagella-associated protein 91;A-kinase anchor protein 1, mitochondrial;c-Myc-binding protein	PRKAR2B;CFAP91;AKAP1;MYCBP	None;AAT1 C3orf15 MAATS1;AKAP149 PRKA1;AMY1
7671	CAMSAP3-MACF1 complex	Human	ACF7-CAMSAP3 complex	Caco2 cells	Q9P1Y5;Q9UPN3	57662;23499	MI:0096-pull down	GO:0030334;GO:0051893	regulation of cell migration;regulation of focal adhesion assembly	None	None	27693509	The binding of MACF1 to CAMSAP3 occurred at the minus ends of microtubules, and this binding tethered the microtubules to actin filaments.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Calmodulin-regulated spectrin-associated protein 3;Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5	CAMSAP3;MACF1	KIAA1543;ABP620 ACF7 KIAA0465 KIAA0754 KIAA1251
7672	DNA polymerase zeta	Human	MAD2L2-POLD2-POLD3-REV3L complex	HEK293 cells	O60673;P49005;Q15054;Q9UI95	5980;5425;10714;10459	MI:0096-pull down;MI:0226-ion exchange chromatography	GO:0019985	translesion synthesis	None	None	24449906	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA polymerase zeta catalytic subunit;DNA polymerase delta subunit 2;DNA polymerase delta subunit 3;Mitotic spindle assembly checkpoint protein MAD2B	REV3L;POLD2;POLD3;MAD2L2	POLZ REV3;None;KIAA0039;MAD2B REV7
7673	ANKS1A-EPHA8-RINL complex	Human	ODIN-EPHA8-RINL complex	HEK293T cells	P29322;Q6ZS11;Q92625	2046;126432;23294	MI:0019-coimmunoprecipitation	GO:0030163	protein catabolic process	14.13	protein/peptide degradation	22291991	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Ephrin type-A receptor 8;Ras and Rab interactor-like protein;Ankyrin repeat and SAM domain-containing protein 1A	EPHA8;RINL;ANKS1A	EEK,HEK3,KIAA1459;None;ANKS1 KIAA0229 ODIN
7676	GPR143-TYR complex	Human	None	COS7 cells	P14679;P51810	7299;4935	MI:0019-coimmunoprecipitation;MI:0055-fluorescent resonance energy transfer	GO:0048471	perinuclear region of cytoplasm	None	None	27720922	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Tyrosinase;G-protein coupled receptor 143	TYR;GPR143	None;OA1
7679	BCL10-CARD14-MALT1 complex	Human	None	HEK293T cells	O95999;Q9BXL6;Q9UDY8	8915;79092;10892	MI:0019-coimmunoprecipitation	GO:0051092;GO:0046330	positive regulation of NF-kappaB transcription factor activity;positive regulation of JNK cascade	None	None	27113748	None	Induction of inflammatory gene expression by psoriasis- associated CARD14 mutants in human primary keratinocytes is MALT1-dependent, pointing to a role of the BCL10-CARD14-MALT1 complex in psoriasis.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	B-cell lymphoma/leukemia 10;Caspase recruitment domain-containing protein 14;Mucosa-associated lymphoid tissue lymphoma translocation protein 1	BCL10;CARD14;MALT1	CIPER, CLAP;CARMA2;MLT
7680	DNAJB11-SDF2 complex	Human	None	HEK293 cells	Q99470;Q9UBS4	6388;51726	MI:0007-anti tag coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0005788;GO:0051082	endoplasmic reticulum lumen;unfolded protein binding	None	None	28597544	The DNAJB11-SDF2 complex acts as component of the BiP chaperone cycle to prevent protein aggregation.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Stromal cell-derived factor 2;DnaJ homolog subfamily B member 11	SDF2;DNAJB11	None;EDJ ERJ3 HDJ9
7681	DNAJB11-SDF2L1 complex	Human	None	HEK293 cells	Q9HCN8;Q9UBS4	23753;51726	MI:0007-anti tag coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0051082;GO:0005783	unfolded protein binding;endoplasmic reticulum	70.07	endoplasmic reticulum	28597544	The DNAJB11-SDF2 complex acts as component of the BiP chaperone cycle to prevent protein aggregation.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Stromal cell-derived factor 2-like protein 1;DnaJ homolog subfamily B member 11	SDF2L1;DNAJB11	None;EDJ ERJ3 HDJ9
7685	ERN1-MAP3K5-TRAF2 complex	Human	ASK1-IRE1alpha-TRAF2 complex	A549 cells	O75460;Q12933;Q99683	2081;7186;4217	MI:0019-coimmunoprecipitation	GO:0007254;GO:0043068;GO:0034976	JNK cascade;positive regulation of programmed cell death;response to endoplasmic reticulum stress	30.01.05.01.02	JNK cascade	27470364	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein kinase/endoribonuclease IRE1;TNF receptor-associated factor 2;Mitogen-activated protein kinase kinase kinase 5	ERN1;TRAF2;MAP3K5	IRE1;TRAP3;ASK1 MAPKKK5 MEKK5
7686	ITCH-NDFIP1-UBE2L3 complex	Human	ITCH-NDFIP1-UBCH7 complex	Bone marrow\u2013derived macrophages	P68036;Q96J02;Q9BT67	7332;83737;80762	MI:0096-pull down	GO:0002862	negative regulation of inflammatory response to antigenic stimulus	None	None	25632008	None	Results suggest that the ITCH-NDFIP1-UBE2L3 complex is essential for effective termination of the inflammatory response.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Ubiquitin-conjugating enzyme E2 L3;E3 ubiquitin-protein ligase Itchy homolog;NEDD4 family-interacting protein 1	UBE2L3;ITCH;NDFIP1	UBCE7 UBCH7;None;N4WBP5
7687	CYLD-ITCH complex	Human	None	Bone marrow\u2013derived macrophages	Q96J02;Q9NQC7	83737;1540	MI:0007-anti tag coimmunoprecipitation;MI:0096-pull down	GO:0050728;GO:0006511;GO:0070536;GO:0070936	negative regulation of inflammatory response;ubiquitin-dependent protein catabolic process;protein K63-linked deubiquitination;protein K48-linked ubiquitination	14.13.01.01	proteasomal degradation (ubiquitin/proteasomal pathway)	22057290	The CYLD-ITCH complex sequentially cleaved Lys63-linked ubiquitin chains and catalyzed Lys48-linked ubiquitination on the kinase Tak1 to terminate inflammatory signaling via tumor necrosis factor.	None	None	Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase Itchy homolog;Ubiquitin carboxyl-terminal hydrolase CYLD	ITCH;CYLD	None;CYLD1 KIAA0849
7692	AKT1-HSPB1-MAPK14-MAPKAPK2 complex	Human	p38 kinase-Akt-Hsp27-MK2 complex	Neurophils	P04792;P31749;P49137;Q16539	3315;207;9261;1432	MI:0007-anti tag coimmunoprecipitation;MI:0096-pull down	GO:0007165	signal transduction	30	CELLULAR COMMUNICATION/SIGNAL TRANSDUCTION MECHANISM	11042204	AKT1 is associated with MAPK14, MAPKAPK2, and HSPB1 in neutrophils. HSPB1 dissociates from the complex upon activation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Heat shock protein beta-1;RAC-alpha serine/threonine-protein kinase;MAP kinase-activated protein kinase 2;Mitogen-activated protein kinase 14	HSPB1;AKT1;MAPKAPK2;MAPK14	HSP27 HSP28;PKB RAC;None;CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A
7693	AKT1-MAPK14-MAPKAPK2 complex	Human	p38 kinase-Akt-MK2 complex	Neutrophils	P31749;P49137;Q16539	207;9261;1432	MI:0007-anti tag coimmunoprecipitation;MI:0096-pull down	GO:0007165	signal transduction	30	CELLULAR COMMUNICATION/SIGNAL TRANSDUCTION MECHANISM	11042204	AKT1 is associated with MAPK14, MAPKAPK2, and HSPB1 in neutrophils. HSPB1 dissociates from the complex upon activation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	RAC-alpha serine/threonine-protein kinase;MAP kinase-activated protein kinase 2;Mitogen-activated protein kinase 14	AKT1;MAPKAPK2;MAPK14	PKB RAC;None;CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A
7694	MAPK14-MAPKAPK3 complex	Human	MK3-p38alpha complex	HL60 cells	Q16539;Q16644	1432;7867	MI:0405-competition binding	GO:0007165	signal transduction	30	CELLULAR COMMUNICATION/SIGNAL TRANSDUCTION MECHANISM	24601623	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Mitogen-activated protein kinase 14;MAP kinase-activated protein kinase 3	MAPK14;MAPKAPK3	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A;None
7696	DONSON-MCM2-MCM7-PCNA-TICRR complex	Human	None	HEK 293FT cells	P12004;P33993;P49736;Q7Z2Z1;Q9NYP3	5111;4176;4171;90381;29980	MI:0007-anti tag coimmunoprecipitation;MI:0052-fluorescence correlation spectroscopy	GO:0006260	DNA replication	10.01.03	DNA synthesis and replication	28191891	None	Mutations in DONSON were found in patients with microcephalic dwarfism.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Proliferating cell nuclear antigen;DNA replication licensing factor MCM7;DNA replication licensing factor MCM2;Treslin;Protein downstream neighbor of Son	PCNA;MCM7;MCM2;TICRR;DONSON	None;CDC47 MCM2;BM28 CCNL1 CDCL1 KIAA0030;C15orf42;C21orf60
7697	MCM8-MCM9 complex	Human	None	HEK 293T cells	Q9NXL9;Q9UJA3	254394;84515	MI:0096-pull down	GO:0005634;GO:0000725	nucleus;recombinational repair	70.10	nucleus	23401855	MCM8-MCM9 complex complex is required for homologous recombination (HR) repair.	None	None	Homo sapiens (Human);Homo sapiens (Human)	DNA helicase MCM9;DNA helicase MCM8	MCM9;MCM8	C6orf61,MCMDC1;C20orf154
7698	MCM8-MCM9-MRE11A-NBN-RAD50 complex	Human	None	HEK293 cells	O60934;P49959;Q92878;Q9NXL9;Q9UJA3	4683;4361;10111;254394;84515	MI:0096-pull down	GO:0000725;GO:0003677	recombinational repair;DNA binding	16.03.01	DNA binding	26215093	MCM8-MCM9 is required for DNA resection by MRE11A-NBN-RAD50 at double-strand breaks to generate ssDNA.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Nibrin;Double-strand break repair protein MRE11;DNA repair protein RAD50;DNA helicase MCM9;DNA helicase MCM8	NBN;MRE11;RAD50;MCM9;MCM8	NBS NBS1 P95;HNGS1 MRE11A;None;C6orf61,MCMDC1;C20orf154
7699	MCPH1-Condensin II complex	Human	None	HEK293T cells	O95347;P42695;Q15554;Q6IBW4;Q86XI2;Q8NEM0;Q9NTJ3;Q9NYB0	10592;23310;7014;29781;54892;79648;10051;54386	MI:0676-tandem affinity purification	GO:0005634;GO:0030261;GO:1901990;GO:0000725	nucleus;chromosome condensation;regulation of mitotic cell cycle phase transition;recombinational repair	70.10;10.03.04.03	nucleus;chromosome condensation	18718915	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Structural maintenance of chromosomes protein 2;Condensin-2 complex subunit D3;Telomeric repeat-binding factor 2;Condensin-2 complex subunit H2;Condensin-2 complex subunit G2;Microcephalin;Structural maintenance of chromosomes protein 4;Telomeric repeat-binding factor 2-interacting protein 1	SMC2;NCAPD3;TERF2;NCAPH2;NCAPG2;MCPH1;SMC4;TERF2IP	CAPE SMC2L1;CAPD3 KIAA0056;TRBF2, TRF2;CAPH2;LUZP5;None;CAPC SMC4L1;DRIP5, RAP1
7700	MCRS1-NDE1 complex	Human	None	HEK 293T cells	Q96EZ8;Q9NXR1	10445;54820	MI:0007-anti tag coimmunoprecipitation;MI:0416-fluorescence microscopy	GO:0005813;GO:0000278	centrosome;mitotic cell cycle	70.05;10.03.01.01	centrosome;mitotic cell cycle	16547491	Results indicate that MCRS1 (p78) is essential for cell viability and it plays a critical role in mitosis and in particular the transition from the prometaphase to the metaphase segment of the mitotic process.	None	Phosphorylation on certain sites of NDE1 leads to disassociation of the MCRS1-NDE1 complex.	Homo sapiens (Human);Homo sapiens (Human)	Microspherule protein 1;Nuclear distribution protein nudE homolog 1	MCRS1;NDE1	INO80Q MSP58;NUDE
7702	MDM2-MDM4-TP53 complex	Human	None	A549 cells	O15151;P04637;Q00987	4194;7157;4193	MI:0007-anti tag coimmunoprecipitation	GO:0031647	regulation of protein stability	None	None	19098711	Results indicate that, in unstressed cells,RYBP probably regulates the stability of p53 by forming a MDM2-MDM4-TP53 complex that prevents the association between MDM2 and p53, thereby inhibiting the E3 ligase of MDM2 from ubiquitinating p53.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein Mdm4;Cellular tumor antigen p53;E3 ubiquitin-protein ligase Mdm2	MDM4;TP53;MDM2	MDMX;P53;None
7703	MDM2-TP53-WWOX complex	Human	None	HCT116 cells	P04637;Q00987;Q9NZC7	7157;4193;51741	MI:0007-anti tag coimmunoprecipitation	GO:0005634;GO:0009411	nucleus;response to UV	70.10	nucleus	16219768	UV light increases nuclear localization of WWOX, MDM2, and TP53(p53), along with their complex formation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cellular tumor antigen p53;E3 ubiquitin-protein ligase Mdm2;WW domain-containing oxidoreductase	TP53;MDM2;WWOX	P53;None;FOR SDR41C1 WOX1
7705	HOXD4-MEIS1-PBX1 complex	Human	None	HEK293 cells	O00470;P09016;P40424	4211;3233;5087	MI:0404-comigration in non denaturing gel electrophoresis	GO:0006355	regulation of DNA-templated transcription	11.02.03.04	transcriptional control	10523646	MEIS1 and PBX1 are non-DNA-binding partners in the protein complex. DNA binding is required for the formation of the complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Homeobox protein Meis1;Homeobox protein Hox-D4;Pre-B-cell leukemia transcription factor 1	MEIS1;HOXD4;PBX1	None;HOX4B;PRL
7706	HOXD9-MEIS1-PBX1 complex	Human	None	HEK293 cells	O00470;P28356;P40424	4211;3235;5087	MI:0404-comigration in non denaturing gel electrophoresis	GO:0006355	regulation of DNA-templated transcription	11.02.03.04	transcriptional control	10523646	MEIS1 and PBX1 are non-DNA-binding partners in the protein complex. DNA binding is required for the formation of the complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Homeobox protein Meis1;Homeobox protein Hox-D9;Pre-B-cell leukemia transcription factor 1	MEIS1;HOXD9;PBX1	None;HOX4C;PRL
7707	HOXD10-MEIS1-PBX1 complex	Human	None	HEK293 cells	O00470;P28358;P40424	4211;3236;5087	MI:0404-comigration in non denaturing gel electrophoresis	GO:0006355	regulation of DNA-templated transcription	11.02.03.04	transcriptional control	10523646	MEIS1 and PBX1 are non-DNA-binding partners in the protein complex. DNA binding is required for the formation of the complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Homeobox protein Meis1;Homeobox protein Hox-D10;Pre-B-cell leukemia transcription factor 1	MEIS1;HOXD10;PBX1	None;HOX4D HOX4E;PRL
7708	PBX1-PKNOX1 complex	Human	PBX-PREP1 complex	HeLa cells	P40424;P55347	5087;5316	MI:0404-comigration in non denaturing gel electrophoresis	GO:0006351;GO:0005634	DNA-templated transcription;nucleus	11;70.10	TRANSCRIPTION;nucleus	9482740	Pbx1-Pknox1 complex is present during mouse embryogenesis.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Pre-B-cell leukemia transcription factor 1;Homeobox protein PKNOX1	PBX1;PKNOX1	PRL;PREP1
7720	EYA1-PAX2-TLX1 complex	Human	Hox-Eya-Pax complex	HEK-293 cells	P31314;Q02962;Q99502	3195;5076;2138	MI:0019-coimmunoprecipitation	GO:0001822	kidney development	47.03.07.01	kidney	17785448	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	T-cell leukemia homeobox protein 1;Paired box protein Pax-2;Eyes absent homolog 1	TLX1;PAX2;EYA1	HOX11 TCL3;None;None
7721	Adenosine A1 receptor - dopamine A1 receptor complex	Human	ADORA1-DRD1 complex	mouse fibroblast Ltk(-) transfected with human A(1)R and D(1)R cDNAs	P21728;P30542	1812;134	MI:0019-coimmunoprecipitation	GO:0060159	regulation of dopamine receptor signaling pathway	None	None	10890919	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	D(1A) dopamine receptor;Adenosine receptor A1	DRD1;ADORA1	None;None
7722	GABABR1-GABABR2 complex	Human	None	HEK293 cells	O75899;Q9UBS5	9568;2550	MI:0019-coimmunoprecipitation	GO:0007214;GO:0007186	gamma-aminobutyric acid signaling pathway;G protein-coupled receptor signaling pathway	30.05.02.24.04;30.05.02.24	gamma-aminobutyric acid signalling pathway;G-protein coupled receptor signalling pathway	9872315	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Gamma-aminobutyric acid type B receptor subunit 2;Gamma-aminobutyric acid type B receptor subunit 1	GABBR2;GABBR1	GPR51 GPRC3B;GPRC3A
7724	GABA receptor GBR1-GBR2-mGluR1 receptor complex	Human	GBR1-GBR2-mGLUR1 complex	HEK293 cells	O75899;Q13255;Q9UBS5	9568;2911;2550	MI:0019-coimmunoprecipitation	GO:0007186;GO:0007269	G protein-coupled receptor signaling pathway;neurotransmitter secretion	30.05.02.24	G-protein coupled receptor signalling pathway	31977183	Activation of GBR enhances mGluR1 signaling, whereas mGluR1 activation inhibits GBR signaling in HEK293 cells. This indicates that mGluR1 and GBR form complexes and modulate each other.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Gamma-aminobutyric acid type B receptor subunit 2;Metabotropic glutamate receptor 1;Gamma-aminobutyric acid type B receptor subunit 1	GABBR2;GRM1;GABBR1	GPR51 GPRC3B;GPRC1A MGLUR1;GPRC3A
7725	D2R-CB1R complex	Human	D2 receptor-CB1 receptor complex	HEK293 cells	P14416;P21554	1813;1268	MI:0019-coimmunoprecipitation	GO:0007186;GO:0070371	G protein-coupled receptor signaling pathway;ERK1 and ERK2 cascade	30.05.02.24	G-protein coupled receptor signalling pathway	15710746	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	D(2) dopamine receptor;Cannabinoid receptor 1	DRD2;CNR1	None;CNR
7726	Adenosine A2A-dopamine D2 receptor complex	Human	ADORA2A-DRD2 complex	HEK-293T cells	P14416;P29274	1813;135	MI:0051-fluorescence technology	GO:0007186;GO:0019933	G protein-coupled receptor signaling pathway;cAMP-mediated signaling	30.05.02.24;30.01.09.07	G-protein coupled receptor signalling pathway;cAMP/cGMP mediated signal transduction	12933819	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	D(2) dopamine receptor;Adenosine receptor A2a	DRD2;ADORA2A	None;ADORA2
7727	MC4R-NPBWR1 complex	Human	GPR7-MC4R complex	HEK293 cells, COS-7 cells	P32245;P48145	4160;2831	MI:0055-fluorescent resonance energy transfer;MI:0411-enzyme linked immunosorbent assay	GO:0005886;GO:0007186	plasma membrane;G protein-coupled receptor signaling pathway	70.02;30.05.02.24	eukaryotic plasma membrane / membrane attached;G-protein coupled receptor signalling pathway	20054210	Melanocortin 3 and 4 receptors (MC3R and MC4R) are known to play an essential role in hypothalamic weight regulation.	MC4R mutations represent the most frequent monogenic cause of obesity to date.	None	Homo sapiens (Human);Homo sapiens (Human)	Melanocortin receptor 4;Neuropeptides B/W receptor type 1	MC4R;NPBWR1	None;GPR7
7728	GHSR-MC3R complex	Human	None	HEK293 cells; COS-7 cells	P41968;Q92847	4159;2693	MI:0055-fluorescent resonance energy transfer;MI:0411-enzyme linked immunosorbent assay	GO:0007186;GO:0005886	G protein-coupled receptor signaling pathway;plasma membrane	30.05.02.24;70.02	G-protein coupled receptor signalling pathway;eukaryotic plasma membrane / membrane attached	20054210	Melanocortin 3 and 4 receptors (MC3R and MC4R) are known to play an essential role in hypothalamic weight regulation.	Mutations in the MC3R are a rare cause of obesity.	None	Homo sapiens (Human);Homo sapiens (Human)	Melanocortin receptor 3;Growth hormone secretagogue receptor type 1	MC3R;GHSR	None;None
7729	A2AR-D2R-CB1R receptor complex	Human	Adenosine A2A-dopamine D2-cannabinoid CB1 receptor complex	HEK293T cells	P14416;P21554;P29274	1813;1268;135	MI:0051-fluorescence technology	GO:0007186	G protein-coupled receptor signaling pathway	30.05.02.24	G-protein coupled receptor signalling pathway	18587404	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	D(2) dopamine receptor;Cannabinoid receptor 1;Adenosine receptor A2a	DRD2;CNR1;ADORA2A	None;CNR;ADORA2
7730	A2AR-CB1R complex	Human	Adenosine A2A-cannabinoid CB1 receptor complex	HEK-293T cells	P21554;P29274	1268;135	MI:0019-coimmunoprecipitation	GO:0007186	G protein-coupled receptor signaling pathway	30.05.02.24	G-protein coupled receptor signalling pathway	17356572	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cannabinoid receptor 1;Adenosine receptor A2a	CNR1;ADORA2A	CNR;ADORA2
7731	D2R-CB1R receptor complex	Human	Dopamine D2-cannabinoid CB1 receptor complex	HEK293T cells	P14416;P21554	1813;1268	MI:0051-fluorescence technology	GO:0007186	G protein-coupled receptor signaling pathway	30.05.02.24	G-protein coupled receptor signalling pathway	18587404	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	D(2) dopamine receptor;Cannabinoid receptor 1	DRD2;CNR1	None;CNR
7733	A2A-mGluR5 receptor complex	Human	Adenosine receptor A2a-metabotropic glutamate receptor 5 complex	HEK-293 cells	P29274;P41594	135;2915	MI:0019-coimmunoprecipitation	GO:0007186;GO:0023041	G protein-coupled receptor signaling pathway;neuronal signal transduction	30.05.02.24	G-protein coupled receptor signalling pathway	12189203	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Adenosine receptor A2a;Metabotropic glutamate receptor 5	ADORA2A;GRM5	ADORA2;GPRC1E,MGLUR5
7734	GHSR-PTGER3 complex	Human	None	HEK293 cells	P43115;Q92847	5733;2693	MI:0007-anti tag coimmunoprecipitation;MI:0012-bioluminescence resonance energy transfer	GO:0007186	G protein-coupled receptor signaling pathway	30.05.02.24	G-protein coupled receptor signalling pathway	18573679	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Prostaglandin E2 receptor EP3 subtype;Growth hormone secretagogue receptor type 1	PTGER3;GHSR	None;None
7736	GHSR-TBXA2R complex	Human	GHSR-TXR alpha complex	HEK293 cells	P21731-3;Q92847	6915;2693	MI:0007-anti tag coimmunoprecipitation;MI:0012-bioluminescence resonance energy transfer	GO:0007186	G protein-coupled receptor signaling pathway	30.05.02.24	G-protein coupled receptor signalling pathway	18573679	None	None	The authors used the TXR alpha splice variant of TBXA2R in their experiments.	Homo sapiens (Human);Homo sapiens (Human)	Isoform 1 of Thromboxane A2 receptor;Growth hormone secretagogue receptor type 1	TBXA2R;GHSR	None;None
7737	GHSR-PTGIR complex	Human	None	HEK293 cells	P43119;Q92847	5739;2693	MI:0007-anti tag coimmunoprecipitation	GO:0007186	G protein-coupled receptor signaling pathway	30.05.02.24	G-protein coupled receptor signalling pathway	18573679	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Prostacyclin receptor;Growth hormone secretagogue receptor type 1	PTGIR;GHSR	PRIPR;None
7738	Intraflagellar transport complex A core complex	Human	IFT122-IFT140-IFT144 core subcomplex; IFT140-IFT122-IFT144 subcomplex of IFT-A complex	HEK293T cells	Q8NEZ3;Q96RY7;Q9HBG6	57728;9742;55764	MI:0019-coimmunoprecipitation	GO:0035721;GO:0007186;GO:0005929;GO:0042073	intraciliary retrograde transport;G protein-coupled receptor signaling pathway;cilium;intraciliary transport	30.05.02.24	G-protein coupled receptor signalling pathway	27932497	The IFT-A complex is required for ciliary entry of G protein-coupled receptors. IFT144-KO cells showed failed ciliary entry of IFT-A and GPCRs and IFT-B accumulation at the bulged tips. This indicates that IFT144 is essential for assembly of the functional IFT-A complex and for ciliary entry of GPCRs.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	WD repeat-containing protein 19;Intraflagellar transport protein 140 homolog;Intraflagellar transport protein 122 homolog	WDR19;IFT140;IFT122	IFT144 KIAA1638;KIAA0590 WDTC2;SPG WDR10 WDR140
7739	Intraflagellar transport complex A TULP3-IFT122-IFT140-IFT144 subcomplex	Human	TULP3-IFT122-IFT140-IFT144 subcomplex of IFT-A complex	HEK293T cells	O75386;Q8NEZ3;Q96RY7;Q9HBG6	7289;57728;9742;55764	MI:0019-coimmunoprecipitation	GO:0035721;GO:0005929;GO:0042073	intraciliary retrograde transport;cilium;intraciliary transport	None	None	27932497	None	TULP3 causes developmental defects through aberrant hedgehog signaling upon its deficiency.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Tubby-related protein 3;WD repeat-containing protein 19;Intraflagellar transport protein 140 homolog;Intraflagellar transport protein 122 homolog	TULP3;WDR19;IFT140;IFT122	TUBL3;IFT144 KIAA1638;KIAA0590 WDTC2;SPG WDR10 WDR140
7740	Intraflagellar transport complex A peripheral subcomplex	Human	IFT43-IFT121-IFT139 peripheral subcomplex; IFT43-IFT121-IFT139 peripheral subcomplex of IFT-A complex	HEK293T cells	Q7Z4L5;Q96FT9;Q9P2L0	79809;112752;57539	MI:0019-coimmunoprecipitation	GO:0035721;GO:0007186;GO:0042073	intraciliary retrograde transport;G protein-coupled receptor signaling pathway;intraciliary transport	30.05.02.24	G-protein coupled receptor signalling pathway	27932497	IFT139-KO cells showed the accumulation of IFT-A, IFT-B, and G protein-coupled receptors at the bulged ciliary tips.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Tetratricopeptide repeat protein 21B;Intraflagellar transport protein 43 homolog;WD repeat-containing protein 35	TTC21B;IFT43;WDR35	IFT139 KIAA1992;C14orf179;IFT121, KIAA1336
7742	GHSR1b-NTSR1 receptor complex	Human	None	NSCLC cells	P30989;Q92847-2	4923;2693	MI:0019-coimmunoprecipitation	GO:0042924	neuromedin U binding	None	None	17018595	GHSR1b-NTSR1 complex functions as neuromedin U receptor in lung cancers.	Growth hormone secretagogue receptor 1b and neurotensin receptor 1, are overexpressed in non-small cell lung cancer cells. The complex GHSR1b-NTSR1 significantly affects the growth of lung cancer cells.	GHSR1b (Q92847-2) is a splice variant of GHSR. The long splice variant GHSR1a (Q92847-1) was not expressed in non-small cell lung cancer cells (NSCLC) (PMID:17018595).	Homo sapiens (Human);Homo sapiens (Human)	Neurotensin receptor type 1;Isoform 1B of Growth hormone secretagogue receptor type 1	NTSR1;GHSR	NTRR;None
7743	D1R-GHSR complex	Human	GHSR-D1R complex	HEK293 cells	P21728;Q92847	1812;2693	MI:0019-coimmunoprecipitation	GO:0007212;GO:0007186;GO:0019933	dopamine receptor signaling pathway;G protein-coupled receptor signaling pathway;cAMP-mediated signaling	30.05.02.24.03;30.05.02.24;30.01.09.07	dopamine receptor signalling pathway;G-protein coupled receptor signalling pathway;cAMP/cGMP mediated signal transduction	16601073	Ghrelin amplifies dopamine signaling by inducing the formation of growth hormone secretagogue receptor/dopamine receptor subtype 1 complexes.	None	None	Homo sapiens (Human);Homo sapiens (Human)	D(1A) dopamine receptor;Growth hormone secretagogue receptor type 1	DRD1;GHSR	None;None
7744	PP1c-Gbeta1 complex	Human	None	HEK293 cells; unstimulated human platelets	P36873;P62136;P62140;P62873	5501;5499;5500;2782	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0070527;GO:0007186	platelet aggregation;G protein-coupled receptor signaling pathway	30.05.02.24	G-protein coupled receptor signalling pathway	28615442	Interaction of Gbeta1 with the catalytic subunit of protein phosphatase 1 was identified in unstimulated platelets, but decreased following platelet stimulation with GPCR agonist thrombin or ADP.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Serine/threonine-protein phosphatase PP1-alpha catalytic subunit;Serine/threonine-protein phosphatase PP1-beta catalytic subunit;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	PPP1CC;PPP1CA;PPP1CB;GNB1	None;PPP1A;None;None
7745	CRF2 beta-D1R receptor complex	Human	Corticotrophin releasing factor type 2 beta receptor-dopamine D1 receptor complex	HEK293 cells	P21728;Q13324-2	1812;1395	MI:0019-coimmunoprecipitation	GO:0019933;GO:0007212;GO:0007186	cAMP-mediated signaling;dopamine receptor signaling pathway;G protein-coupled receptor signaling pathway	30.01.09.07;30.05.02.24.03;30.05.02.24	cAMP/cGMP mediated signal transduction;dopamine receptor signalling pathway;G-protein coupled receptor signalling pathway	31969820	The immunoreactivity for CRF2beta was similar to that of CRF2alpha in the endoplasmic compartment but significantly higher in the Golgi compartment.	None	CRF2-beta (Q13324-2) is a splice variant of CRHR2.	Homo sapiens (Human);Homo sapiens (Human)	D(1A) dopamine receptor;Isoform CRF2-beta of Corticotropin-releasing factor receptor 2	DRD1;CRHR2	None;CRF2R CRH2R
7746	CRF2 alpha-D1R receptor complex	Human	D1R-CRF2 alpha receptor complex	HEK293T cells	P21728;Q13324-1	1812;1395	MI:0019-coimmunoprecipitation;MI:0051-fluorescence technology	GO:0007186;GO:0019933;GO:0007212	G protein-coupled receptor signaling pathway;cAMP-mediated signaling;dopamine receptor signaling pathway	30.05.02.24;30.01.09.07;30.05.02.24.03	G-protein coupled receptor signalling pathway;cAMP/cGMP mediated signal transduction;dopamine receptor signalling pathway	25073922	Heteromerization between D1 and CRF2 receptors could be responsible for the synergism between dopamine and CRH transmission.	None	CRF2-alpha (Q13324-1) is a splice variant of CRHR2.	Homo sapiens (Human);Homo sapiens (Human)	D(1A) dopamine receptor;Isoform CRF2-alpha of Corticotropin-releasing factor receptor 2	DRD1;CRHR2	None;CRF2R CRH2R
7747	5-HT2A-5-HT2C receptor complex	Human	Serotonin 2A-2C receptor complex	HEK293 cells	P28223;P28335	3356;3358	MI:0051-fluorescence technology	GO:0019722;GO:0007186	calcium-mediated signaling;G protein-coupled receptor signaling pathway	30.01.09.03;30.05.02.24	Ca2+ mediated signal transduction;G-protein coupled receptor signalling pathway	30157263	None	Dysfunctional 5-HT2AR and 5-HT2CR are implicated in neuropsychiatric disorders.	None	Homo sapiens (Human);Homo sapiens (Human)	5-hydroxytryptamine receptor 2A;5-hydroxytryptamine receptor 2C	HTR2A;HTR2C	HTR2;HTR1C
7748	MC2R-MRAP complex	Human	None	HEK293 cells	Q01718;Q8TCY5	4158;56246	MI:0019-coimmunoprecipitation;MI:0051-fluorescence technology	GO:0007186	G protein-coupled receptor signaling pathway	30.05.02.24	G-protein coupled receptor signalling pathway	21177829	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Adrenocorticotropic hormone receptor;Melanocortin-2 receptor accessory protein	MC2R;MRAP	ACTHR;C21orf61 FALP
7749	VIPR1-VIPR2 complex	Human	VPAC1-VPAC2 complex	COS cells	P32241;P41587	7433;7434	MI:0012-bioluminescence resonance energy transfer;MI:0055-fluorescent resonance energy transfer	GO:0005886;GO:0007186	plasma membrane;G protein-coupled receptor signaling pathway	70.02;30.05.02.24	eukaryotic plasma membrane / membrane attached;G-protein coupled receptor signalling pathway	16244179	The VPAC1-VPAC2 heterooligomers were modulated by vasoactive intestinal polypeptide (VIP) binding.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Vasoactive intestinal polypeptide receptor 1;Vasoactive intestinal polypeptide receptor 2	VIPR1;VIPR2	None;VIP2R
7750	SCTR-VIPR1 complex	Human	SCTR-VPAC1 complex	COS cells	P32241;P47872	7433;6344	MI:0012-bioluminescence resonance energy transfer;MI:0055-fluorescent resonance energy transfer	GO:0007186	G protein-coupled receptor signaling pathway	30.05.02.24	G-protein coupled receptor signalling pathway	16244179	SCTR-VPAC1 and SCTR-VPAC2 receptor hetero-oligomers were unaffected by ligand treatment.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Vasoactive intestinal polypeptide receptor 1;Secretin receptor	VIPR1;SCTR	None;None
7751	SCTR-VIPR2 complex	Human	SCTR-VPAC2 complex	COS cells	P41587;P47872	7434;6344	MI:0012-bioluminescence resonance energy transfer;MI:0055-fluorescent resonance energy transfer	GO:0007186	G protein-coupled receptor signaling pathway	30.05.02.24	G-protein coupled receptor signalling pathway	16244179	SCTR-VPAC1 and SCTR-VPAC2 receptor hetero-oligomers were unaffected by ligand treatment.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Vasoactive intestinal polypeptide receptor 2;Secretin receptor	VIPR2;SCTR	VIP2R;None
7753	Drd2-Ghsr1a receptor complex	Human	None	aequorin-HEK293 cells	P14416;Q92847-1	1813;2693	MI:0051-fluorescence technology	GO:0019722;GO:0007212;GO:0023041;GO:0007186	calcium-mediated signaling;dopamine receptor signaling pathway;neuronal signal transduction;G protein-coupled receptor signaling pathway	30.01.09.03;30.05.02.24.03;30.05.02.24	Ca2+ mediated signal transduction;dopamine receptor signalling pathway;G-protein coupled receptor signalling pathway	22284186	None	None	Ghsr1a (Q92847-1) is a splice variant of GHSR.	Homo sapiens (Human);Homo sapiens (Human)	D(2) dopamine receptor;Isoform 1A of Growth hormone secretagogue receptor type 1	DRD2;GHSR	None;None
7754	CB2-SQSTM1 receptor complex	Human	SQSTM1-CB2 receptor complex; p65-CB2 receptor complex; Sequestosome 1-cannabinoid receptor 2 complex	HEK293 cells	P34972;Q13501	1269;8878	MI:0019-coimmunoprecipitation	GO:0007186;GO:0038171	G protein-coupled receptor signaling pathway;cannabinoid signaling pathway	30.05.02.24	G-protein coupled receptor signalling pathway	31616248	None	Dysfunction of SQSTM1 and CB2 alone is involved in disorders affecting brain and bone.	None	Homo sapiens (Human);Homo sapiens (Human)	Cannabinoid receptor 2;Sequestosome-1	CNR2;SQSTM1	CB2A CB2B;ORCA OSIL
7755	YAP-cMYC complex	Human	cMYC-YAP complex	osteosarcoma cells (MNNG-HOS and U-2OS)	P01106;P46937	4609;10413	MI:0019-coimmunoprecipitation	GO:0006096;GO:0006351	glycolytic process;DNA-templated transcription	02.01;11	glycolysis and gluconeogenesis;TRANSCRIPTION	30587459	The G protein-coupled receptor S1PR3 contributes to the formation of the cMYC-YAP complex which enhances the transcription of the glycolysis enzyme PGAM1.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Myc proto-oncogene protein;Transcriptional coactivator YAP1	MYC;YAP1	BHLHE39;YAP65
7758	RAMP1-VIPR1 complex	Human	RAMP1-VPAC1 complex	HEK293 cells	O60894;P32241	10267;7433	MI:0663-confocal microscopy	GO:0005886	plasma membrane	70.02	eukaryotic plasma membrane / membrane attached	12446722	The RAMP1-VIPR1 complex does not show altered phenotypic behavior compared with the VIPR1 alone, as determined using radioligand binding in COS-7 cells.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Receptor activity-modifying protein 1;Vasoactive intestinal polypeptide receptor 1	RAMP1;VIPR1	None;None
7759	RAMP3-VIPR1 complex	Human	RAMP3-VPAC1 complex	HEK293 cells	O60896;P32241	10268;7433	MI:0663-confocal microscopy	GO:0005886	plasma membrane	70.02	eukaryotic plasma membrane / membrane attached	12446722	The RAMP3-VIPR1 complex does not show altered phenotypic behavior compared with the VIPR1 alone, as determined using radioligand binding in COS-7 cells.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Receptor activity-modifying protein 3;Vasoactive intestinal polypeptide receptor 1	RAMP3;VIPR1	None;None
7760	RAMP2-VIPR1 complex	Human	RAMP2-VPAC1 complex	HEK293 cells	O60895;P32241	10266;7433	MI:0663-confocal microscopy	GO:0005886;GO:0007165	plasma membrane;signal transduction	70.02;30	eukaryotic plasma membrane / membrane attached;CELLULAR COMMUNICATION/SIGNAL TRANSDUCTION MECHANISM	12446722	The RAMP2-VIPR1 heterodimer displays a significant enhancement of agonist-mediated phosphoinositide hydrolysis with no change in cAMP stimulation compared with the VIPR1 alone. The RAMP2-VIPR1 complex does not show altered phenotypic behavior compared with the VIPR1 alone, as determined using radioligand binding in COS-7 cells.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Receptor activity-modifying protein 2;Vasoactive intestinal polypeptide receptor 1	RAMP2;VIPR1	None;None
7761	PTH1R-RAMP2 complex	Human	None	HEL293 cells	O60895;Q03431	10266;5745	MI:0663-confocal microscopy	GO:0005886	plasma membrane	70.02	eukaryotic plasma membrane / membrane attached	12446722	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Receptor activity-modifying protein 2;Parathyroid hormone/parathyroid hormone-related peptide receptor	RAMP2;PTH1R	None;PTHR PTHR1
7762	PTH2R-RAMP3 complex	Human	None	HEK293 cells	O60896;P49190	10268;5746	MI:0663-confocal microscopy	GO:0005886	plasma membrane	70.02	eukaryotic plasma membrane / membrane attached	12446722	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Receptor activity-modifying protein 3;Parathyroid hormone 2 receptor	RAMP3;PTH2R	None;PTHR2
7763	GCGR-RAMP2 complex	Human	None	HEK293 cells	O60895;P47871	10266;2642	MI:0411-enzyme linked immunosorbent assay;MI:0416-fluorescence microscopy	GO:0005886;GO:0007186	plasma membrane;G protein-coupled receptor signaling pathway	70.02;30.05.02.24	eukaryotic plasma membrane / membrane attached;G-protein coupled receptor signalling pathway	26198634	RAMP2 regulates both ligand binding and G protein selectivity of the glucagon receptor.	The glucagon receptor is an important target for treating type 2 diabetes.	None	Homo sapiens (Human);Homo sapiens (Human)	Receptor activity-modifying protein 2;Glucagon receptor	RAMP2;GCGR	None;None
7764	CRHR1-RAMP2 complex	Human	CRF1-RAMP2 complex	HEK 293S cells; CHO-K1 cells	O60895;P34998	10266;104909134	MI:0411-enzyme linked immunosorbent assay	GO:0005886;GO:0007186	plasma membrane;G protein-coupled receptor signaling pathway	70.02;30.05.02.24	eukaryotic plasma membrane / membrane attached;G-protein coupled receptor signalling pathway	22946657	The CRHR1-RAMP2 complex resulted in enhanced elevation of intracellular calcium to CRF (corticotrophin releasing factor) and urocortin 1 but not sauvagine.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Receptor activity-modifying protein 2;Corticotropin-releasing factor receptor 1	RAMP2;CRHR1	None;CRFR,CRFR1,CRHR
7765	RAMP1-VIPR2 complex	Human	RAMP1-VPAC2 complex	HEK 293S cells; CHO-K1 cells	O60894;P41587	10267;7434	MI:0411-enzyme linked immunosorbent assay	GO:0005886;GO:0007186	plasma membrane;G protein-coupled receptor signaling pathway	70.02;30.05.02.24	eukaryotic plasma membrane / membrane attached;G-protein coupled receptor signalling pathway	22946657	VIPR2 can interact with all three RAMPs; for RAMPs 1 and 2, this leads to enhanced coupling to Gi/o/t/z.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Receptor activity-modifying protein 1;Vasoactive intestinal polypeptide receptor 2	RAMP1;VIPR2	None;VIP2R
7766	RAMP2-VIPR2 complex	Human	RAMP2-VPAC2 complex	HEK 293S cells; CHO-K1 cells	O60895;P41587	10266;7434	MI:0411-enzyme linked immunosorbent assay	GO:0005886;GO:0007186	plasma membrane;G protein-coupled receptor signaling pathway	70.02;30.05.02.24	eukaryotic plasma membrane / membrane attached;G-protein coupled receptor signalling pathway	22946657	VIPR2 can interact with all three RAMPs; for RAMPs 1 and 2, this leads to enhanced coupling to Gi/o/t/z.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Receptor activity-modifying protein 2;Vasoactive intestinal polypeptide receptor 2	RAMP2;VIPR2	None;VIP2R
7767	RAMP3-VIPR2 complex	Human	RAMP3-VPAC2 complex	HEK 293S cells; CHO-K1 cells	O60896;P41587	10268;7434	MI:0411-enzyme linked immunosorbent assay	GO:0005886;GO:0007186	plasma membrane;G protein-coupled receptor signaling pathway	70.02;30.05.02.24	eukaryotic plasma membrane / membrane attached;G-protein coupled receptor signalling pathway	22946657	VIPR2 can interact with all three RAMPs; for RAMPs 1 and 2, this leads to enhanced coupling to Gi/o/t/z.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Receptor activity-modifying protein 3;Vasoactive intestinal polypeptide receptor 2	RAMP3;VIPR2	None;VIP2R
7768	GHSR1A-SST5 complex	Human	None	HEK293 cells	P35346;Q92847-1	6755;2693	MI:0051-fluorescence technology	GO:0019933;GO:0007186;GO:0030073	cAMP-mediated signaling;G protein-coupled receptor signaling pathway;insulin secretion	30.01.09.07;30.05.02.24	cAMP/cGMP mediated signal transduction;G-protein coupled receptor signalling pathway	23112170	GHS-R1a-SST5 complex suppresses glucose-stimulated insulin secretion from pancreatic beta-cells and cAMP accumulation. The formation of GHS-R1a-SST5 complexes is dependent on the ratio of ghrelin to SST. A high ratio enhances heteromer formation and Galpha(i/o) coupling, whereas a low ratio destabilizes heteromer conformation, restoring GHS-R1a-Galpha(q11) coupling.	None	GHSR1A (Q92847-1) is a splice variant of GHSR.	Homo sapiens (Human);Homo sapiens (Human)	Somatostatin receptor type 5;Isoform 1A of Growth hormone secretagogue receptor type 1	SSTR5;GHSR	None;None
7769	GHSR1a-Dopamine D1 receptor complex	Human	GHSR1a-DRD1 complex	HEK293A cells	P21728;Q92847-1	1812;2693	MI:0428-imaging technique	GO:0007186;GO:0007212;GO:0097009	G protein-coupled receptor signaling pathway;dopamine receptor signaling pathway;energy homeostasis	30.05.02.24;30.05.02.24.03	G-protein coupled receptor signalling pathway;dopamine receptor signalling pathway	23161547	None	None	GHSR1a (Q92847-1) is a splice variant of GHSR.	Homo sapiens (Human);Homo sapiens (Human)	D(1A) dopamine receptor;Isoform 1A of Growth hormone secretagogue receptor type 1	DRD1;GHSR	None;None
7770	GHSR1a-Melanocortin receptor 3 complex	Human	GHSR1a-MC3R complex	HEK293A cells	P41968;Q92847-1	4159;2693	MI:0428-imaging technique	GO:0007186;GO:0097009	G protein-coupled receptor signaling pathway;energy homeostasis	30.05.02.24	G-protein coupled receptor signalling pathway	23161547	None	None	GHSR1a (Q92847-1) is a splice variant of GHSR.	Homo sapiens (Human);Homo sapiens (Human)	Melanocortin receptor 3;Isoform 1A of Growth hormone secretagogue receptor type 1	MC3R;GHSR	None;None
7771	GHSR1a-Serotonin 2c receptor complex	Human	GHSR1a-HTR2C complex	HEK293A cells	P21728;P28335	1812;3358	MI:0428-imaging technique	GO:0007186;GO:0097009	G protein-coupled receptor signaling pathway;energy homeostasis	30.05.02.24	G-protein coupled receptor signalling pathway	23161547	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	D(1A) dopamine receptor;5-hydroxytryptamine receptor 2C	DRD1;HTR2C	None;HTR1C
7772	SEPTIN3A-SEPTIN3B-SEPTIN5 complex	Human	None	frontal cortex	Q99719;Q9UH03-1;Q9UH03-2	5413;55964;55964	MI:0019-coimmunoprecipitation	GO:0007416;GO:0048666	synapse assembly;neuron development	41.05.13.01	synaptogenesis	15200239	The expression and distribution patterns of septin 3 isoforms A and B were similar and resembled that of another septin, CDCrel-1. Immunoprecipitation studies revealed that septin 3A, 3B, and CDCrel-1 form a complex in the frontal cortex of human brain. These findings, taken together, suggest that septin 3A and 3B, along with CDCrel-1, play some fundamental role(s) in synaptogenesis and neuronal development.	None	SEPTIN3A (Q9UH03-1) and SEPTIN3B (Q9UH03-2) are splice variants of SEPTIN3.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Septin-5;Isoform 1 of Neuronal-specific septin-3;Isoform 2 of Neuronal-specific septin-3	SEPTIN5;SEPTIN3;SEPTIN3	PNUTL1 SEPT5;SEP3 SEPT3;SEP3 SEPT3
7773	AGTR1-MAS1 complex	Human	None	HEK293 cells	P04201;P30556	4142;185	MI:0019-coimmunoprecipitation	GO:0002018	renin-angiotensin regulation of aldosterone production	None	None	15809376	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Proto-oncogene Mas;Type-1 angiotensin II receptor	MAS1;AGTR1	MAS;AGTR1A AGTR1B AT2R1 AT2R1B
7779	CCND3-CRABP2-RARA  complex	Human	CCND3-CRABPII-RARA complex	None	P10276;P29373;P30281	5914;1382;896	MI:0018-two hybrid	GO:0016049	cell growth	40.01	cell growth / morphogenesis	12482873	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Retinoic acid receptor alpha;Cellular retinoic acid-binding protein 2;G1/S-specific cyclin-D3	RARA;CRABP2;CCND3	NR1B1;None;None
7780	ESR1--EP300-NCOA2 complex	Human	ESR1--EP300-SRC2 complex	None	P03372;Q09472;Q15596	2099;2033;10499	MI:0096-pull down	GO:0016573	histone acetylation	None	None	11689448	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Estrogen receptor;Histone acetyltransferase p300;Nuclear receptor coactivator 2	ESR1;EP300;NCOA2	ESR NR3A1;P300;BHLHE75 SRC2 TIF2
7781	PAT complex	Human	CCDC47-WDR83OS complex	HEK293 cells	Q96A33;Q9Y284	57003;51398	MI:0004-affinity chromatography technology;MI:0096-pull down	GO:0072546;GO:0061077	EMC complex;chaperone-mediated protein folding	None	None	32814900	According to a model for multipass membrane protein biogenesis (PMID: 36261528), nascent membrane proteins trigger not only PAT complex recruitment but also the NCLN-NOMO1-TMEM147 complex (CORUM-ID 7865) and the RAB5IF-TMCO1 complex (CORUM-ID 8796).	None	CCDC47 and WDR83OS (Asterix) form an obligate complex, because knockdown or knockout of either protein results in substantial loss of the other.	Homo sapiens (Human);Homo sapiens (Human)	PAT complex subunit CCDC47;PAT complex subunit Asterix	CCDC47;WDR83OS	None;C19orf56
7784	RNF8-ATX3-p97 complex	Human	ATXN3-NPLOC4-RNF8-UFD1-VCP complex	HEK293 cells	O76064;P54252;P55072;Q8TAT6;Q92890	9025;4287;7415;55666;7353	MI:0007-anti tag coimmunoprecipitation	GO:0010212;GO:0006281;GO:0005634	response to ionizing radiation;DNA repair;nucleus	10.01.05.01;70.10	DNA repair;nucleus	31613024	The RNF8-ATX3-p97 complex regulates proteasome-dependent homeostasis of RNF8 under physiological conditions. Under genotoxic stress, when RNF8 is rapidly recruited to sites of DNA lesions, the p97\u2013ATX3 machinery stimulates the extraction of RNF8 from chromatin to balance DNA repair pathway choice and promote cell survival after ionising radiation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase RNF8;Ataxin-3;Transitional endoplasmic reticulum ATPase;Nuclear protein localization protein 4 homolog;Ubiquitin recognition factor in ER-associated degradation protein 1	RNF8;ATXN3;VCP;NPLOC4;UFD1	KIAA0646;ATX3,MJD,MJD1,SCA3;None;KIAA1499 NPL4;UFD1L
7786	MMS22L\u2013TONSL complex	Human	None	HeLa cells	Q6ZRQ5;Q96HA7	253714;4796	MI:0007-anti tag coimmunoprecipitation	GO:0035825	homologous recombination	None	None	27797818	The MMS22L\u2013TONSL complex localizes to replication forks under unperturbed conditions and its recruitment is increased during replication stress in human cells.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Protein MMS22-like;Tonsoku-like protein	MMS22L;TONSL	C6orf167;IKBR NFKBIL2
7787	MYOD1-TEAD4-VGLL4 complex	Human	None	HEK293 cells	P15172;Q14135;Q15561	4654;9686;7004	MI:0007-anti tag coimmunoprecipitation	GO:0045663;GO:0045893	positive regulation of myoblast differentiation;positive regulation of DNA-templated transcription	11.02.03.04.01	transcription activation	31328806	The MYOD1-TEAD4-VGLL4 complex drives the expression of MyoG to initiate muscle satellite cell (MuSC) differentiation. MuSCs are resident adult stem cells that are activated after muscle injury and have the differentiation ability to form myotubes	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Myoblast determination protein 1;Transcription cofactor vestigial-like protein 4;Transcriptional enhancer factor TEF-3	MYOD1;VGLL4;TEAD4	BHLHC1 MYF3 MYOD;KIAA0121;RTEF1 TCF13L1 TEF3
7788	MAD2L2-RIF1-SHLD2-TP53BP1 complex	Human	FAM35A-RIF1-REV7-53BP1 complex	HeLa S3 cells	Q12888;Q5UIP0;Q86V20;Q9UI95	7158;55183;54537;10459	MI:0007-anti tag coimmunoprecipitation	GO:0005634;GO:0006281	nucleus;DNA repair	70.10;10.01.05.01	nucleus;DNA repair	29789392	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	TP53-binding protein 1;Telomere-associated protein RIF1;Shieldin complex subunit 2;Mitotic spindle assembly checkpoint protein MAD2B	TP53BP1;RIF1;SHLD2;MAD2L2	None;None;FAM35A,RINN2;MAD2B REV7
7789	STX1A-STXBP1 complex	Human	None	HEK293 cells	P61764;Q16623	6812;6804	MI:0007-anti tag coimmunoprecipitation;MI:0055-fluorescent resonance energy transfer	GO:0016082	synaptic vesicle priming	None	None	32643828	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Syntaxin-binding protein 1;Syntaxin-1A	STXBP1;STX1A	UNC18A;STX1
7791	ALAS1-CLPP-CLPX complex	Human	None	HepG2 cells	O76031;P13196;Q16740	10845;211;8192	MI:0096-pull down	GO:0005759;GO:0042541	mitochondrial matrix;hemoglobin biosynthetic process	70.16.07	mitochondrial matrix	27496948	ALAS1 forms a complex with ClpXP in a heme-dependent manner.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial;5-aminolevulinate synthase, non-specific, mitochondrial;ATP-dependent Clp protease proteolytic subunit, mitochondrial	CLPX;ALAS1;CLPP	None;ALAS3 ALASH;None
7792	AXL-DOCK1-ELMO2-MET complex	Human	None	U373-MG-cells	P08581;P30530;Q14185;Q96JJ3	4233;558;1793;63916	MI:0096-pull down;MI:0416-fluorescence microscopy	GO:0005886;GO:0007010;GO:0004713	plasma membrane;cytoskeleton organization;protein tyrosine kinase activity	70.02;42.04	eukaryotic plasma membrane / membrane attached;cytoskeleton/structural proteins	30108175	The AXL-DOCK1-ELMO2-MET complex can be detected on the plasma membrane by immunostaining or by immune co-precipitation. The protein complex promotes the activation RAC1, thereby controlling the dynamic receptor clustering and actin cytoskeleton reorganization.	Results indicate that the activation of the AXL-DOCK1-ELMO2-MET protein complex and the downstream target RAC1 play a critical role in regulating the hepatocyte growth factor (HGF)-dependent cell migration and invasion of glioblastoma cells.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Hepatocyte growth factor receptor;Tyrosine-protein kinase receptor UFO;Dedicator of cytokinesis protein 1;Engulfment and cell motility protein 2	MET;AXL;DOCK1;ELMO2	None;UFO;None;CED12A KIAA1834
7793	FOXK1-PLK1-SPAG9 complex	Human	None	HEK293T cells	O60271;P53350;P85037	9043;5347;221937	MI:0007-anti tag coimmunoprecipitation	None	None	None	None	26468278	The FOXK1-PLK1-SPAG9 complex is found predominantly in cells arrested in the G2/M phase, which express the highest levels of PLK1.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	C-Jun-amino-terminal kinase-interacting protein 4;Serine/threonine-protein kinase PLK1;Forkhead box protein K1	SPAG9;PLK1;FOXK1	HSS KIAA0516 MAPK8IP4 SYD1;PLK;MNF
7794	FOXK2-PLK1-SPAG9 complex	Human	None	HEK293T cells	O60271;P53350;Q01167	9043;5347;3607	MI:0007-anti tag coimmunoprecipitation	None	None	None	None	26468278	FOXK2-PLK1-SPAG9 complex is found predominantly in cells arrested in the G2/M phase, which express the highest levels of PLK1.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	C-Jun-amino-terminal kinase-interacting protein 4;Serine/threonine-protein kinase PLK1;Forkhead box protein K2	SPAG9;PLK1;FOXK2	HSS KIAA0516 MAPK8IP4 SYD1;PLK;ILF,ILF1
7795	MC1R-MC3R complex	Human	None	COS-7 cells	P41968;Q01726	4159;4157	MI:0012-bioluminescence resonance energy transfer	GO:0004930	G protein-coupled receptor activity	None	None	15582585	None	None	Results indicate that the MC1R-MC3R complex exists as constitutively pre-formed dimers.	Homo sapiens (Human);Homo sapiens (Human)	Melanocortin receptor 3;Melanocyte-stimulating hormone receptor	MC3R;MC1R	None;MSHR
7797	GHSR-HTR2C complex	Human	None	HEK293 cells	P28335;Q92847	3358;2693	MI:0416-fluorescence microscopy	GO:0019722;GO:0004930	calcium-mediated signaling;G protein-coupled receptor activity	30.01.09.03	Ca2+ mediated signal transduction	23161547	Co-expression of the unedited 5-HT2C-INI receptor, but not the partially edited 5-HT2C-VSV isoform, in cells stably expressing the GHS-R1a receptor attenuated GHS-R1a-mediated intracellular calcium influx following ghrelin and MK0677 treatment.	None	None	Homo sapiens (Human);Homo sapiens (Human)	5-hydroxytryptamine receptor 2C;Growth hormone secretagogue receptor type 1	HTR2C;GHSR	HTR1C;None
7798	ADRB2-PTGER1 complex	Human	None	HEK293 cells	P07550;P34995	154;5731	MI:0007-anti tag coimmunoprecipitation;MI:0012-bioluminescence resonance energy transfer	GO:0004930	G protein-coupled receptor activity	None	None	16670773	Alone, PTGER-1 does not appear to have a significant direct effect on airway tone but acts as a modulator of the ADRB2, altering G?s coupling via steric interactions imposed by the ADRB2-PTGER1 heterodimeric signaling complex and ultimately affecting ADRB2-mediated bronchial relaxation.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Beta-2 adrenergic receptor;Prostaglandin E2 receptor EP1 subtype	ADRB2;PTGER1	ADRB2R B2AR;None
7802	PTGIR-TBXA2R complex	Human	None	COS-7 cells	P21731;P43119	6915;5739	MI:0012-bioluminescence resonance energy transfer	GO:0005886;GO:0004930	plasma membrane;G protein-coupled receptor activity	70.02	eukaryotic plasma membrane / membrane attached	23162015	None	The authors speculate that changes in prostacyclin and thromboxane signaling after perturbation of membrane cholesterol may contribute to cardiovascular disease associated with hypercholesterolemia.	None	Homo sapiens (Human);Homo sapiens (Human)	Thromboxane A2 receptor;Prostacyclin receptor	TBXA2R;PTGIR	None;PRIPR
7803	ADORA2-GAS2L2 complex	Human	None	HEK293 cells	P29274;Q8NHY3	135;246176	MI:0007-anti tag coimmunoprecipitation;MI:0055-fluorescent resonance energy transfer	GO:0005886;GO:0004930	plasma membrane;G protein-coupled receptor activity	70.02	eukaryotic plasma membrane / membrane attached	23994616	GAS2L2 is a new effector that controls the action of ADORA2 by modulating its ability to regulate the G alpha s-mediated cAMP contents.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Adenosine receptor A2a;GAS2-like protein 2	ADORA2A;GAS2L2	ADORA2;GAR17
7805	ARRB2-GNB1-GNG2-PTH1R complex	Human	None	HEK293 cells	P32121;P59768;P62873;Q03431	409;54331;2782;5745	MI:0055-fluorescent resonance energy transfer;MI:0416-fluorescence microscopy	GO:0007186;GO:0005886	G protein-coupled receptor signaling pathway;plasma membrane	30.05.02.24;70.02	G-protein coupled receptor signalling pathway;eukaryotic plasma membrane / membrane attached	23297229	Results strongly support a scaffolding role for arrestin that results in the stabilization of a complex of PTHR and Gbeta/gamma that accelerates G-protein activation and increases the steady-state levels of active Gs, thus resulting in prolonged generation of cAMP.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Beta-arrestin-2;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;Parathyroid hormone/parathyroid hormone-related peptide receptor	ARRB2;GNG2;GNB1;PTH1R	ARB2 ARR2;None;None;PTHR PTHR1
7806	MAP2K5-PRKCD-SQSTM1 complex	Human	None	HEK293 cells	Q05655;Q13163;Q13501	5580;5607;8878	MI:0007-anti tag coimmunoprecipitation	None	None	None	None	12813044	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein kinase C delta type;Dual specificity mitogen-activated protein kinase kinase 5;Sequestosome-1	PRKCD;MAP2K5;SQSTM1	PKCD;MEK5 MKK5 PRKMK5;ORCA OSIL
7807	7SK snRNP-LEC complex	Human	ELL-ICE1-ICE2-LARP7-MEPCE-ZC3H8 complex	HeLa cells	P55199;Q4G0J3;Q659A1;Q7L2J0;Q8N5P1;Q9Y2F5	8178;51574;79664;56257;84524;23379	MI:0007-anti tag coimmunoprecipitation	GO:0005634;GO:0006357;GO:0016073	nucleus;regulation of transcription by RNA polymerase II;snRNA metabolic process	70.10	nucleus	28254838	Expression of mammalian RNAPII-specific spliceosomal snRNA and snoRNA genes is supported by the little elongation complex (LEC) that promotes both transcription initiation and elongation on snRNA genes. Results demonstrated that the human 7SK snRNP, composed of the 7SK snRNA, LARP7, and MePCE, specifically associates with LEC to promote RNAPII-mediated snRNA and snoRNA synthesis.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	RNA polymerase II elongation factor ELL;La-related protein 7;Little elongation complex subunit 2;7SK snRNA methylphosphate capping enzyme;Zinc finger CCCH domain-containing protein 8;Little elongation complex subunit 1	ELL;LARP7;ICE2;MEPCE;ZC3H8;ICE1	C19orf17;None;BRCC1 NARG2;BCDIN3;ZC3HDC8;KIAA0947
7808	METTL3-METTL14-WTAP complex	Human	None	HEK293 cells	Q15007;Q86U44;Q9HCE5	9589;56339;57721	MI:0007-anti tag coimmunoprecipitation	GO:0005634;GO:0060612;GO:0044771	nucleus;adipose tissue development;meiotic cell cycle phase transition	70.10	nucleus	24407421	RNA N6-adenosine methyltransferase complex consisting of Wilms\u2019 tumor 1-associating protein (WTAP), methyltransferase like 3 (METTL3), and METTL14 positively controls adipogenesis by promoting cell cycle transition in mitotic clonal expansion during adipogenesis.	Wtap heterozygous knockout mice are protected from diet-induced obesity with smaller size and number of adipocytes, leading to improved insulin sensitivity.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Pre-mRNA-splicing regulator WTAP;N6-adenosine-methyltransferase catalytic subunit;N6-adenosine-methyltransferase non-catalytic subunit	WTAP;METTL3;METTL14	KIAA0105;MTA70;KIAA1627
7809	m(6)A methyltransferase complex	Human	None	HeLa cells	Q15007;Q5T200;Q69YN4;Q75N03;Q86U44;Q9HCE5	9589;23091;25962;79872;56339;57721	MI:0007-anti tag coimmunoprecipitation	GO:0036396	RNA N6-methyladenosine methyltransferase complex	None	None	29507755	Mammalian mRNA methylation N6-methyladenosine (m6A) sculpts the transcriptome in order to affect mRNA processing and metabolism, and represents a mechanism to regulate gene expression analogous to epigenetic DNA and histone methylations.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Pre-mRNA-splicing regulator WTAP;Zinc finger CCCH domain-containing protein 13;Protein virilizer homolog;E3 ubiquitin-protein ligase Hakai;N6-adenosine-methyltransferase catalytic subunit;N6-adenosine-methyltransferase non-catalytic subunit	WTAP;ZC3H13;VIRMA;CBLL1;METTL3;METTL14	KIAA0105;KIAA0853;KIAA1429;HAKAI RNF188;MTA70;KIAA1627
7812	HDAC1-HDAC2-MIER1-MIER2 complex	Human	None	HeLa cells	Q13547;Q8N108;Q8N344;Q92769	3065;57708;54531;3066	MI:0007-anti tag coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0005634	nucleus	70.10	nucleus	19061646	A substantial fraction of purified Flag-HA-CDYL exists in the free form, at least two multiprotein subcomplexes appear to exist, the HDAC1-HDAC2-MIER1-MIER2 complex and the CDYL-HDAC1-HDAC2-MIER1-MIER2 complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone deacetylase 1;Mesoderm induction early response protein 1;Mesoderm induction early response protein 2;Histone deacetylase 2	HDAC1;MIER1;MIER2;HDAC2	RPD3L1;KIAA1610;KIAA1193;None
7813	CDYL-complex	Human	None	HeLa cells	O95785;Q13127;Q13547;Q15047;Q8N108;Q92769;Q96KQ7;Q9H9B1;Q9Y232	58525;5978;3065;9869;57708;3066;10919;79813;9425	MI:0007-anti tag coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0005634;GO:0045892;GO:0016570	nucleus;negative regulation of DNA-templated transcription;histone modification	70.10;11.02.03.04.03	nucleus;transcription repression	19061646	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein Wiz;RE1-silencing transcription factor;Histone deacetylase 1;Histone-lysine N-methyltransferase SETDB1;Mesoderm induction early response protein 1;Histone deacetylase 2;Histone-lysine N-methyltransferase EHMT2;Histone-lysine N-methyltransferase EHMT1;Chromodomain Y-like protein	WIZ;REST;HDAC1;SETDB1;MIER1;HDAC2;EHMT2;EHMT1;CDYL	ZNF803;NRSF XBR;RPD3L1;ESET KIAA0067 KMT1E;KIAA1610;None;BAT8 C6orf30 G9A KMT1C NG36;EUHMTASE1 GLP KIAA1876 KMT1D;CDYL1
7814	CDYL-CAF1-MCM complex	Human	None	U2OS cells	P25205;P33991;P33992;P33993;P49736;Q09028;Q13111;Q13112;Q14566;Q15047;Q15910;Q96KQ7;Q9Y232	4172;4173;4174;4176;4171;5928;10036;8208;4175;9869;2146;10919;9425	MI:0007-anti tag coimmunoprecipitation;MI:0071-molecular sieving	GO:0044843;GO:0016570	cell cycle G1/S phase transition;histone modification	None	None	28402439	Experiments identified the chromodomain protein and transcription corepressor CDYL, through its interaction with histone chaperone CAF-1 and DNA helicase MCM during replication, as a key player in mediating the inheritance and maintenance of H3K9me2/3 and H3K27me2/3. The complex plays an important role in the maintenance of repressive histone marks during replication.	None	The CDYL-CAF1-MCM complex is a supercomplex that consists of CDYL, the CAF-1 complex, the MCM complex as well as the three histone methyltransferases (KMTs) SETDB1, EZH2 and EHMT2. Results support not only a role of CDYL in connecting CAF-1 and MCM complexes, but also a function of CDYL in the recruitment of KMTs by the CAF-1-CDYL-MCM machinery.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA replication licensing factor MCM3;DNA replication licensing factor MCM4;DNA replication licensing factor MCM5;DNA replication licensing factor MCM7;DNA replication licensing factor MCM2;Histone-binding protein RBBP4;Chromatin assembly factor 1 subunit A;Chromatin assembly factor 1 subunit B;DNA replication licensing factor MCM6;Histone-lysine N-methyltransferase SETDB1;Histone-lysine N-methyltransferase EZH2;Histone-lysine N-methyltransferase EHMT2;Chromodomain Y-like protein	MCM3;MCM4;MCM5;MCM7;MCM2;RBBP4;CHAF1A;CHAF1B;MCM6;SETDB1;EZH2;EHMT2;CDYL	None;CDC21;CDC46;CDC47 MCM2;BM28 CCNL1 CDCL1 KIAA0030;RBAP48;CAF CAF1P150;CAF1A CAF1P60 MPHOSPH7 MPP7;None;ESET KIAA0067 KMT1E;KMT6;BAT8 C6orf30 G9A KMT1C NG36;CDYL1
7817	ASH2L-MRTFA complex	Human	ASH2-MKL1 complex	H1299 cells	Q969V6;Q9UBL3	57591;9070	MI:0402-chromatin immunoprecipitation assay	GO:0045893	positive regulation of DNA-templated transcription	11.02.03.04.01	transcription activation	25746000	MKL1 recruits ASH2 to activate MMP9 transcription and promote lung cancer cell migration and invasion.	MMP9 is primarily responsible for catabolizing collagen type IV and elastin, paving the way for lung cancer metastasis.	None	Homo sapiens (Human);Homo sapiens (Human)	Myocardin-related transcription factor A;Set1/Ash2 histone methyltransferase complex subunit ASH2	MRTFA;ASH2L	KIAA1438 MAL MKL1;ASH2L1
7819	MLKL-PGAM5-RIPK1-RIPK3 complex	Human	None	HeLa cells	Q13546;Q8NB16;Q96HS1;Q9Y572	8737;197259;192111;11035	MI:0007-anti tag coimmunoprecipitation	GO:0070265;GO:0031966	necrotic cell death;mitochondrial membrane	None	None	22265414	The extrinsic necrosis pathway relies on necrosome components consisting of the kinases RIPK1, RIPK3, and mixed lineage kinase domain-like protein MLKL. Downstream of the necrosome are two isoforms of PGAM5, which specifically associate with the necrosome after necrosis induction, resulting in PGAM5 phosphorylation and activation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Receptor-interacting serine/threonine-protein kinase 1;Mixed lineage kinase domain-like protein;Serine/threonine-protein phosphatase PGAM5, mitochondrial;Receptor-interacting serine/threonine-protein kinase 3	RIPK1;MLKL;PGAM5;RIPK3	RIP, RIP1;None;None;RIP3
7820	BMI1-CBX8-MLLT3-RING1 complex	Human	None	HEK293T cells	P35226;P42568;Q06587;Q9HC52	648;4300;6015;57332	MI:0007-anti tag coimmunoprecipitation;MI:0071-molecular sieving	GO:0006355	regulation of DNA-templated transcription	11.02.03.04	transcriptional control	23891621	MLLT3 (AF9) associates with components of the Polycomb group (PcG) PRC1 complex, including CBX8, BMI1, RING1B and RING1A. The association between AF9\u2013CBX8 affects ENaCa gene expression.	None	MLLT3 (AF9) and CBX8 are found within a 300-400 kDa complex	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Polycomb complex protein BMI-1;Protein AF-9;E3 ubiquitin-protein ligase RING1;Chromobox protein homolog 8	BMI1;MLLT3;RING1;CBX8	PCGF4 RNF51;AF9 YEATS3;RNF1;PC3 RC1
7822	MOB4-STK26 complex	Human	MOB4-MST4 complex	HEK293FT cells	Q9P289;Q9Y3A3	51765;25843	MI:0007-anti tag coimmunoprecipitation;MI:0071-molecular sieving;MI:0663-confocal microscopy	GO:0035330	regulation of hippo signaling	None	None	30072378	The MOB4-STK26 complex is a noncanonical regulator of the Hippo\u2013YAP pathway.	In contrast to the tumor-suppressor effect of the MST1-MOB1 complex, the MOB4-STK26 promoted growth and migration of PANC-1 cells (pancreatic cancer).	STK26 auto-phosphorylation at Thr-327/328 is critical for binding MOB4	Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein kinase 26;MOB-like protein phocein	STK26;MOB4	MASK MST4;MOB3 MOBKL3 PHOCN PREI3
7823	MOB1A-STK3-STK38 complex	Human	MOB1-MST2-NDR1 complex	HEK293FT cells	Q13188;Q15208;Q9H8S9	6788;11329;55233	MI:0007-anti tag coimmunoprecipitation	GO:0016301	kinase activity	None	None	18362890	MOB1A, STK3 and STK38 form a tripartite complex, and the okadaic acid treatment enhances this formation. STK3 phosphorylates STK38 and this phosphorylation is enhanced by MOB1.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein kinase 3;Serine/threonine-protein kinase 38;MOB kinase activator 1A	STK3;STK38;MOB1A	KRS1, MST2;NDR1;C2orf6 MOB4B MOBK1B MOBKL1B
7825	CCZ1-MON1A-MON1B-RMC1 complex	Human	None	HEK293 cells	P86791;Q7L1V2;Q86VX9;Q96DM3	221960;22879;84315;29919	MI:0007-anti tag coimmunoprecipitation;MI:0071-molecular sieving	GO:0016236	macroautophagy	None	None	29038162	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Vacuolar fusion protein CCZ1 homolog;Vacuolar fusion protein MON1 homolog B;Vacuolar fusion protein MON1 homolog A;Regulator of MON1-CCZ1 complex	CCZ1;MON1B;MON1A;RMC1	C7orf28A;HSRG1,KIAA0872,SAND2;SAND1;C18orf8,MIC1,WDR98
7826	ATP9A-DOP1B-MON2 complex	Human	None	None	O75110;Q7Z3U7;Q9Y3R5	10079;23041;9980	MI:0007-anti tag coimmunoprecipitation;MI:0416-fluorescence microscopy	GO:0061355	Wnt protein secretion	None	None	30213940	SNX3-retromer requires an evolutionary conserved ATP9A-DOP1B-MON2 complex to mediate Wntless sorting and Wnt secretion.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Probable phospholipid-transporting ATPase IIA;Protein MON2 homolog;Protein dopey-2	ATP9A;MON2;DOP1B	ATPIIA KIAA0611;KIAA1040,SF21;C21orf5,DOPEY2,KIAA0933
7830	AMOT-MPP5-NF2-PATJ complex	Human	Angiomotin-Merlin-PALS1-PATJ complex	HEK293 cells	P35240;Q4VCS5;Q8N3R9;Q8NI35	4771;154796;64398;10207	MI:0007-anti tag coimmunoprecipitation	GO:0070160;GO:0043409	tight junction;negative regulation of MAPK cascade	None	None	21481793	Results suggest that Merlin, through competitive binding to Angiomotin, releases Rich1 from the Angiomotin-inhibitory complex, allowing Rich1 to inactivate Rac1, ultimately leading to attenuation of Rac1 and Ras-MAPK pathways.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Merlin;Angiomotin;Protein PALS1;InaD-like protein	NF2;AMOT;PALS1;PATJ	SCH;KIAA1071;MPP5;CIPP INADL
7831	MRAS-PPP1CA-SHOC2 complex	Human	None	HeLa cells	O14807;P62136;Q9UQ13	22808;5499;8036	MI:0007-anti tag coimmunoprecipitation	GO:0043408	regulation of MAPK cascade	None	None	16630891	The MRAS-PPP1CA-SHOC2 complex is a highly specific effector of M-Ras that plays an essential role in MAPK pathway activation, both in response to growth factors and in tumor cell lines with Ras mutations. M-Ras and Shoc2 have a substrate specifying function in that they lead to specific dephosphorylation of P-S259, but not P-S338, on Raf.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Ras-related protein M-Ras;Serine/threonine-protein phosphatase PP1-alpha catalytic subunit;Leucine-rich repeat protein SHOC-2	MRAS;PPP1CA;SHOC2	RRAS3;PPP1A;KIAA0862
7832	MRAS-PPP1CB-SHOC2 complex	Human	None	HEK293T cells	O14807;P62140;Q9UQ13	22808;5500;8036	MI:0007-anti tag coimmunoprecipitation	GO:0016310;GO:0016020	phosphorylation;membrane	None	None	24211266	MRAS and SHOC2 function both as targeting and substrate-specifying subunits for PP1. MRAS will stimulate formation of the complex within plasma membrane microdomains at sites of activation by extracellular signals. Additionally, MRAS and SHOC2 selectively stimulate the phosphatase activity of the complex, both in vivo and in vitro, against the S259 RAF inhibitory site, but not other phosphorylation sites within the same RAF molecule.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Ras-related protein M-Ras;Serine/threonine-protein phosphatase PP1-beta catalytic subunit;Leucine-rich repeat protein SHOC-2	MRAS;PPP1CB;SHOC2	RRAS3;None;KIAA0862
7833	MRAS-SCRIB-SHOC2 complex	Human	None	HEK293T cells	O14807;Q14160;Q9UQ13	22808;23513;8036	MI:0007-anti tag coimmunoprecipitation	GO:0043408	regulation of MAPK cascade	None	None	24211266	In the presence of active MRAS, the SHOC2-SCRIB complex has the ability to positively and negatively regulate the ERK pathway and thus has antagonistically bifunctional or paradoxical properties.	SHOC2 and MRAS form a complex with SCRIB, a polarity protein with tumor suppressor properties.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Ras-related protein M-Ras;Protein scribble homolog;Leucine-rich repeat protein SHOC-2	MRAS;SCRIB;SHOC2	RRAS3;CRIB1 KIAA0147 LAP4 SCRB1 VARTUL;KIAA0862
7834	MRC2-PLAU-PLAUR complex	Human	None	U937 cells	P00749;Q03405;Q9UBG0	5328;5329;9902	MI:0030-cross-linking study;MI:0096-pull down	GO:0009986;GO:0048771	cell surface;tissue remodeling	None	None	10636902	The plasminogen activation cascade system, directed by urokinase and the urokinase receptor, plays a key role in extracellular proteolysis during tissue remodeling. MRC2 proved capable of binding strongly to a single type of collagen, collagen V.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Urokinase-type plasminogen activator;Urokinase plasminogen activator surface receptor;C-type mannose receptor 2	PLAU;PLAUR;MRC2	None;MO3 UPAR;CLEC13E ENDO180 KIAA0709 UPARAP
7835	MRNIP-MRE11-NBN-RAD50 complex	Human	None	HEK293 cells	O60934;P49959;Q6NTE8;Q92878	4683;4361;51149;10111	MI:0007-anti tag coimmunoprecipitation	GO:0005634;GO:1990391;GO:0045739;GO:0006974	nucleus;DNA repair complex;positive regulation of DNA repair;cellular response to DNA damage stimulus	70.10;32.01.09	nucleus;DNA damage response	27568553	Cells depleted of MRNIP display impaired chromatin loading of the MRN complex, resulting in reduced DNA end resection and defective ATM-mediated DNA damage signaling, a reduced ability to repair DNA breaks, and radiation sensitivity. MRNIP phosphorylation on serine 115 leads to its nuclear localization, and this modification is required for MRNIP\u2019s role in promoting genome stability.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Nibrin;Double-strand break repair protein MRE11;MRN complex-interacting protein;DNA repair protein RAD50	NBN;MRE11;MRNIP;RAD50	NBS NBS1 P95;HNGS1 MRE11A;C5orf45;None
7836	GOLGA2-PCDC10-STK26 complex	Human	CCM3-GCKIII-GM130 complex	SaOS2 cells	Q08379;Q9BUL8;Q9P289	2801;11235;51765	MI:0007-anti tag coimmunoprecipitation	GO:0005794;GO:0051683;GO:0016477;GO:0030011	Golgi apparatus;establishment of Golgi localization;cell migration;maintenance of cell polarity	70.08;34.05.01	Golgi;cell migration	20332113	PDCD10 (CCM3) is located on the Golgi apparatus, forming a complex with proteins of the germinal center kinase III (GCKIII) family and GM130, a Golgi-resident protein. Cells depleted of PDCD10 show a disassembled Golgi apparatus.	Mutations in PDCD10 (CCM3)  result in cerebral cavernous malformations, a major cause of cerebral hemorrhage.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Golgin subfamily A member 2;Programmed cell death protein 10;Serine/threonine-protein kinase 26	GOLGA2;PDCD10;STK26	None;CCM3,TFAR15;MASK MST4
7837	MTREX-ZFC3H1 complex	Human	MTR4-ZFC3H1 complex;	HeLa Kyoto cells	O60293;P42285	196441;23517	MI:0007-anti tag coimmunoprecipitation;MI:0019-coimmunoprecipitation	GO:0005634;GO:0006401	nucleus;RNA catabolic process	70.10;01.03.16.01	nucleus;RNA degradation	27871484	RNA length and polyadenylation status are biochemical parameters discriminating whether a nucleoplasmic exosome substrate is likely to be targeted by the NEXT (MTREX-RBM7-ZCCHC8 complex) or the PAXT (MTREX-ZFC3H1 complex) pathways.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Zinc finger C3H1 domain-containing protein;Exosome RNA helicase MTR4	ZFC3H1;MTREX	CCDC131 KIAA0546 PSRC2;DOB1 KIAA0052 MTR4 SKIV2L2
7838	MUC1-RELA complex	Human	MUC1-p65 complex	DM6 cells	P15941;Q04206	4582;5970	MI:0096-pull down	GO:0005634;GO:0045893	nucleus;positive regulation of DNA-templated transcription	70.10;11.02.03.04.01	nucleus;transcription activation	22021035	Chromatin immunoprecipitation and Real-Time PCR experiments revealed that MUC1/22TR upregulated IL-6 and TNF-alpha expression by binding to their promoter regions in a RELA-dependent manner both in MUC1-transfected cancer cells and in human breast cancer cells that express endogenous MUC1.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Mucin-1;Transcription factor p65	MUC1;RELA	PUM;NFKB3
7839	MUC1-SH3KBP1 complex	Human	CIN85-MUC1 complex	MDA- MB-231 cells	P15941;Q96B97	4582;30011	MI:0096-pull down;MI:0416-fluorescence microscopy	GO:0005886;GO:0005737;GO:0005856;GO:0016477	plasma membrane;cytoplasm;cytoskeleton;cell migration	70.02;70.03;70.04;34.05.01	eukaryotic plasma membrane / membrane attached;cytoplasm;cytoskeleton;cell migration	24072600	By associating with SH3KBP1 (CIN85) on invadopodia, MUC1 regulates its role in cell migration and invasion. SH3KBP1 (CIN85) associates with the hypoglycosylated tumor form of MUC1.	MUC1 and SH3KBP1 (CIN85) are both over-expressed in early as well as advanced clinical stages of breast cancer and co-localize on invadopodia-like structures implicated in cell invasion.	None	Homo sapiens (Human);Homo sapiens (Human)	Mucin-1;SH3 domain-containing kinase-binding protein 1	MUC1;SH3KBP1	PUM;CIN85
7840	GRB2-MUC1-SOS1 complex	Human	None	MCF-7 breast cancer cells	P15941;P62993;Q07889	4582;2885;6654	MI:0096-pull down	GO:0023052	signaling	30.01	cellular signalling	7664271	None	The MUC1 antigen is detectable at elevated levels in the plasma of women with metastatic breast cancer and has been used to monitor their clinical course.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mucin-1;Growth factor receptor-bound protein 2;Son of sevenless homolog 1	MUC1;GRB2;SOS1	PUM;ASH;None
7841	EME1-MUS81 complex	Human	None	Escherichia coli	Q96AY2;Q96NY9	146956;80198	MI:0007-anti tag coimmunoprecipitation	GO:0006260;GO:0004519	DNA replication;endonuclease activity	10.01.03	DNA synthesis and replication	12721304	The endonuclease activity of EME1-MUS81 complex is specifically targeted to flap/ fork structures. The efficiency of cleavage of Holliday junctions can be enhanced by inclusion of homologous sequences that are known to result in breathing of the synthetic junction substrate.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Crossover junction endonuclease EME1;Crossover junction endonuclease MUS81	EME1;MUS81	MMS4;None
7844	dREAM-like complex	Human	None	T98G cells	Q08999;Q09028;Q14186;Q16254;Q52LA3;Q5TKA1;Q6MZP7;Q96GY3	5934;5928;7027;1874;91750;286826;132660;55957	MI:0019-coimmunoprecipitation	GO:0051726	regulation of cell cycle	10.03.01	mitotic cell cycle and cell cycle control	17531812	dREAM-like complex containing RBL2 (p130) and E2F4 exists in quiescent cells and dissociates in S phase when LIN9, LIN37, LIN52, and LIN54 form a subcomplex that binds to B-MYB (MYBL2).  The expressionof a majority of dREAM-like complex target genes was significantly higher in cycling cells compared to G0-arrested cells.	None	The complex alternatively contains E2F4 or E2F5 and DP1 or DP2.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Retinoblastoma-like protein 2;Histone-binding protein RBBP4;Transcription factor Dp-1;Transcription factor E2F4;Protein lin-52 homolog;Protein lin-9 homolog;Protein lin-54 homolog;Protein lin-37 homolog	RBL2;RBBP4;TFDP1;E2F4;LIN52;LIN9;LIN54;LIN37	RB2;RBAP48;DP1;None;C14orf46;BARA TGS;CXCDC1 KIAA2037;None
7845	MYBL2-LIN9-LIN37-LIN52-LIN54 complex	Human	None	T98G cells	P10244;Q52LA3;Q5TKA1;Q6MZP7;Q96GY3	4605;91750;286826;132660;55957	MI:0019-coimmunoprecipitation	GO:0051726	regulation of cell cycle	10.03.01	mitotic cell cycle and cell cycle control	17531812	MuvB proteins LIN9, LIN37, LIN52, and LIN54 remained associated with each other in S phase and bound B-MYB (MYBL2).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Myb-related protein B;Protein lin-52 homolog;Protein lin-9 homolog;Protein lin-54 homolog;Protein lin-37 homolog	MYBL2;LIN52;LIN9;LIN54;LIN37	BMYB;C14orf46;BARA TGS;CXCDC1 KIAA2037;None
7847	MYD88-TIRAP-TLR4 complex	Human	TLR4-TIRAP-MYD88 complex; Toll-like receptor 4-TIRAP-MYD88 complex; TLR4-MAL-MYD88 complex	HEK293 cels	O00206;P58753;Q99836	7099;114609;4615	MI:0007-anti tag coimmunoprecipitation	GO:0034142;GO:0005886;GO:0045087;GO:0002221;GO:0002224;GO:0002755;GO:0051092;GO:0043410;GO:0006952	toll-like receptor 4 signaling pathway;plasma membrane;innate immune response;pattern recognition receptor signaling pathway;toll-like receptor signaling pathway;MyD88-dependent toll-like receptor signaling pathway;positive regulation of NF-kappaB transcription factor activity;positive regulation of MAPK cascade;defense response	70.02;36.25.16.01	eukaryotic plasma membrane / membrane attached;innate immune response (invertebrates and vertebrates)	19948740	Targeting of TLR4 and MyD88 to phosphatidylinositol 4,5-bisphosphate (PIP2) sites on the plasma membrane by TIRAP launches the TLR4-mediated MyD88-dependent signaling pathway to activate NF-kappaB and MAPK. TIRAP binds to PIP2 sites and facilitates the association between TLR4 and MyD88. AIP1 (ASK1-interacting protein-1) disrupts formation of the TLR4-TIRAP-MyD88 complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Toll-like receptor 4;Toll/interleukin-1 receptor domain-containing adapter protein;Myeloid differentiation primary response protein MyD88	TLR4;TIRAP;MYD88	None;MAL;None
7851	APC/C-ANAPC16 complex	Human	None	HeLa cells	P30260;Q13042;Q96DE5;Q9H1A4;Q9UJX2;Q9UJX3;Q9UJX4;Q9UJX5;Q9UJX6	996;8881;119504;64682;8697;51434;51433;29945;29882	MI:0007-anti tag coimmunoprecipitation;MI:0029-cosedimentation through density gradient	None	None	None	None	20360068	Immunoblot experiments show that ANAPC16 (C10orf104) is present throughout the cell cycle, and density gradient centrifugation experiments indicate that most of ANAPC16 is associated with the APC/C.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cell division cycle protein 27 homolog;Cell division cycle protein 16 homolog;Anaphase-promoting complex subunit 16;Anaphase-promoting complex subunit 1;Cell division cycle protein 23 homolog;Anaphase-promoting complex subunit 7;Anaphase-promoting complex subunit 5;Anaphase-promoting complex subunit 4;Anaphase-promoting complex subunit 2	CDC27;CDC16;ANAPC16;ANAPC1;CDC23;ANAPC7;ANAPC5;ANAPC4;ANAPC2	ANAPC3 D0S1430E D17S978E;ANAPC6;C10orf104 CENP-27;TSG24;ANAPC8;APC7;APC5;APC4;APC2 KIAA1406
7853	NAA10-NAA16 complex	Human	None	HEK293 cells	P41227;Q6N069	8260;79612	MI:0019-coimmunoprecipitation	GO:0006474	N-terminal protein amino acid acetylation	None	None	19480662	The NAA10-NAA16 complex acetylates NatA-type N-termini in vitro. Specific knockdown of NAA16 induces cell death, suggesting an essential role for NAA16 in human cells.	None	None	Homo sapiens (Human);Homo sapiens (Human)	N-alpha-acetyltransferase 10;N-alpha-acetyltransferase 16, NatA auxiliary subunit	NAA10;NAA16	ARD1 ARD1A TE2;NARG1L NAT2
7854	NAA10-NAA15_NAA50 complex	Human	None	HEK293 cells	P41227;Q9BXJ9;Q9GZZ1	8260;80155;80218	MI:0019-coimmunoprecipitation;MI:0416-fluorescence microscopy	GO:0006474;GO:0005737	N-terminal protein amino acid acetylation;cytoplasm	70.03	cytoplasm	16507339	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	N-alpha-acetyltransferase 10;N-alpha-acetyltransferase 15, NatA auxiliary subunit;N-alpha-acetyltransferase 50	NAA10;NAA15;NAA50	ARD1 ARD1A TE2;GA19 NARG1 NATH TBDN100;MAK3 NAT13 NAT5
7855	NAA30-NAA35-NAA38 complex	Human	NatC complex; Mak3-Mak10-hMak31 complex	HEK293 cells	Q147X3;Q5VZE5;Q9BRA0	122830;60560;84316	MI:0007-anti tag coimmunoprecipitation;MI:0428-imaging technique	GO:0005737;GO:0006474;GO:0051726	cytoplasm;N-terminal protein amino acid acetylation;regulation of cell cycle	70.03;10.03.01	cytoplasm;mitotic cell cycle and cell cycle control	19398576	The human NAA30-NAA35-NAA38 complex (NatC) subunits are located in the cytoplasm and associated with ribosomes. NatC knockdown induces p53-dependent cell death and growth arrest in human cell lines.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	N-alpha-acetyltransferase 30;N-alpha-acetyltransferase 35, NatC auxiliary subunit;N-alpha-acetyltransferase 38, NatC auxiliary subunit	NAA30;NAA35;NAA38	C14orf35 MAK3 NAT12;EGAP MAK10;LSMD1 MAK31 PFAAP2
7856	NAA20-NAA25 complex	Human	NatB complex; hNAT3-hMDM20 complex	HEK293 cells	P61599;Q14CX7	51126;80018	MI:0019-coimmunoprecipitation	GO:0006474;GO:0005737;GO:0051726	N-terminal protein amino acid acetylation;cytoplasm;regulation of cell cycle	70.03;10.03.01	cytoplasm;mitotic cell cycle and cell cycle control	18570629	The NAA20-NAA25 complex is associated with ribosomes. After knock-down of NAA20-NAA25 complex subunits, cells displayed a significantly reduced cellular proliferation.	None	None	Homo sapiens (Human);Homo sapiens (Human)	N-alpha-acetyltransferase 20;N-alpha-acetyltransferase 25, NatB auxiliary subunit	NAA20;NAA25	NAT5;C12orf30 MDM20 NAP1
7857	ANO1-KCNE1 complex	Human	KCNE1-TMEM16A complex	HEK293 cells	P15382;Q5XXA6	3753;55107	MI:0096-pull down;MI:0416-fluorescence microscopy	GO:1902476;GO:0016020	chloride transmembrane transport;membrane	None	None	33373586	The interaction between ANO1 and KCNE1 induces a sustained voltage-dependent chloride current in the absence of elevated cytoplasmic Ca2+, which, physiologically, responds to the blood pressure regulating renin-angiotensin system in proximal tubule cells.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Potassium voltage-gated channel subfamily E member 1;Anoctamin-1	KCNE1;ANO1	None;DOG1 ORAOV2 TAOS2 TMEM16A
7858	ANO1-KCNE5 complex	Human	KCNE5-TMEM16A complex	HEK293 cells	Q5XXA6;Q9UJ90	55107;23630	MI:0096-pull down;MI:0416-fluorescence microscopy	GO:0016020;GO:1902476	membrane;chloride transmembrane transport	None	None	33373586	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Anoctamin-1;Potassium voltage-gated channel subfamily E regulatory beta subunit 5	ANO1;KCNE5	DOG1 ORAOV2 TAOS2 TMEM16A;AMMECR2 KCNE1L
7859	INIP-INTS3-NABP1 complex	Human	SSB2-INTS3-SSBIP1 complex	HEK293 cells	Q68E01;Q96AH0;Q9NRY2	65123;64859;58493	MI:0007-anti tag coimmunoprecipitation;MI:0071-molecular sieving	GO:0005634;GO:0010212;GO:0000724;GO:0007165	nucleus;response to ionizing radiation;double-strand break repair via homologous recombination;signal transduction	70.10;30	nucleus;CELLULAR COMMUNICATION/SIGNAL TRANSDUCTION MECHANISM	19605351	NABP1 and NABP2 form two separate complexes with similar structures, and both are required for efficient homologous recombination dependent repair of DNA double strand breaks (DSBs)  and ataxia telangiectasia-mutated (ATM)-dependent signaling pathways. NABP complexes are also required for cellular resistance to ionizing radiation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrator complex subunit 3;SOSS complex subunit B2;SOSS complex subunit C	INTS3;NABP1;INIP	C1orf193 C1orf60;OBFC2A,SSB2;C9orf80 SSBIP1
7860	INIP-INTS3-NABP2 complex	Human	SSB1-INTS3-SSBIP1 complex	HEK293 cells	Q68E01;Q9BQ15;Q9NRY2	65123;79035;58493	MI:0007-anti tag coimmunoprecipitation;MI:0071-molecular sieving	GO:0000724;GO:0005634;GO:0010212;GO:0007165	double-strand break repair via homologous recombination;nucleus;response to ionizing radiation;signal transduction	70.10;30	nucleus;CELLULAR COMMUNICATION/SIGNAL TRANSDUCTION MECHANISM	19605351	NABP1 and NABP2 form two separate complexes with similar structures, and both are required for efficient homologous recombination dependent repair of DNA double strand breaks (DSBs) and ataxia telangiectasia-mutated (ATM)-dependent signaling pathways. NABP complexes are also required for cellular resistance to ionizing radiation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrator complex subunit 3;SOSS complex subunit B1;SOSS complex subunit C	INTS3;NABP2;INIP	C1orf193 C1orf60;OBFC2B SSB1;C9orf80 SSBIP1
7861	NACA-BTF3 complex	Human	NAC complex	HeLa cells	P20290;Q13765	689;4666	MI:0007-anti tag coimmunoprecipitation;MI:0071-molecular sieving;MI:0416-fluorescence microscopy	GO:0006412;GO:0005829	translation;cytosol	12.04	translation	10982809	The NAC complex is the first cytosolic factor to contact the nascent polypeptide chain as it grows on the ribosome and thus may be key in regulating early events in protein folding and transport. It has been established that NAC prevents SRP (signal recognition particle) binding to inappropriate nascent chains, i.e. those lacking a signal peptide. NAC also prevents binding of inappropriate ribosomes to translocons on the ER by blocking the putative ribosomal M-site.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Transcription factor BTF3;Nascent polypeptide-associated complex subunit alpha	BTF3;NACA	NACB;None
7862	NALCN-UNC79-UNC80 complex	Human	None	HEK293T cells; hippocampal neurons	Q8IZF0;Q8N2C7;Q9P2D8	259232;285175;57578	MI:0007-anti tag coimmunoprecipitation	GO:0035725;GO:0022840;GO:0005886	sodium ion transmembrane transport;leak channel activity;plasma membrane	70.02	eukaryotic plasma membrane / membrane attached	21040849	Extracellular Ca2+ influences excitability in hippocampal neurons through the NALCN-UNC79-UNC80 complex in a G protein-dependent fashion.	None	UNC79 indirectly associates with NALCN through its interaction with UNC80.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Sodium leak channel NALCN;Protein unc-80 homolog;Protein unc-79 homolog	NALCN;UNC80;UNC79	VGCNL1;C2orf21 KIAA1843;KIAA1409
7863	NBAS-RINT1-ZW10 complex	Human	NRZ complex	HeLa cells	A2RRP1;O43264;Q6NUQ1	51594;9183;60561	MI:0007-anti tag coimmunoprecipitation;MI:0029-cosedimentation through density gradient;MI:0416-fluorescence microscopy	GO:0016020;GO:0006890;GO:0016192	membrane;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;vesicle-mediated transport	20.09.07	vesicular transport (Golgi network, etc.)	20462495	The NBAS-RINT1-ZW10 complex likely acts as a tethering complex for retrograde trafficking of COPI vesicles from the Golgi to the endoplasmic reticulum.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	NBAS subunit of NRZ tethering complex;Centromere/kinetochore protein zw10 homolog;RAD50-interacting protein 1	NBAS;ZW10;RINT1	NAG;None;None
7864	NCBP1-NCBP3 complex	Human	Cap-binding complex	HeLa cells	Q09161;Q53F19	4686;55421	MI:0007-anti tag coimmunoprecipitation	GO:0000339;GO:0051607;GO:0051028	RNA cap binding;defense response to virus;mRNA transport	None	None	26382858	The RNA cap structure is bound by the highly conserved nuclear cap-binding complex (CBC), a central factor, known to orchestrate most downstream RNA biogenesis processes such as pre-mRNA splicing, 3'-end processing, nonsense-mediated decay, nuclear\u2013cytoplasmic transport and recruitment of translation factors in the cytoplasm.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Nuclear cap-binding protein subunit 1;Nuclear cap-binding protein subunit 3	NCBP1;NCBP3	CBP80 NCBP;C17orf85
7865	NCLN-NOMO1-TMEM147 complex	Human	None	HEK293T cells	Q15155;Q969V3;Q9BVK8	23420;56926;10430	MI:0019-coimmunoprecipitation;MI:0029-cosedimentation through density gradient;MI:0416-fluorescence microscopy	GO:0038092;GO:0000139;GO:0061077	nodal signaling pathway;Golgi membrane;chaperone-mediated protein folding	None	None	20538592	Nicalin (NCLN) and its binding partner NOMO form a complex that was shown to modulate Nodal signaling in developing zebrafish embryos. TMEM147 is a novel core component of the Nicalin-NOMO complex. According to a model for multipass membrane protein biogenesis (PMID: 36261528), nascent membrane proteins trigger not only PAT complex (CORUM-ID 7781) recruitment but also the NCLN-NOMO1-TMEM147 complex and the RAB5IF-TMCO1 complex (CORUM-ID 8796).	None	Since the authors did not specify NOMO, we used isoform NOMO1.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Nodal modulator 1;Nicalin;Transmembrane protein 147	NOMO1;NCLN;TMEM147	PM5;None;None
7866	NDFIP1-NDFIP2 complex	Human	None	HEK293 cells	Q9BT67;Q9NV92	80762;54602	MI:0007-anti tag coimmunoprecipitation	None	None	None	None	20534535	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	NEDD4 family-interacting protein 1;NEDD4 family-interacting protein 2	NDFIP1;NDFIP2	N4WBP5;KIAA1165 N4WBP5A
7867	CFAP410-NEK1-SPATA7 complex	Human	C21ORF2-NEK1-SPATA7 complex	HEK293 cells	O43822;Q96PY6;Q9P0W8	755;4750;55812	MI:0416-fluorescence microscopy;MI:0676-tandem affinity purification	GO:0036064;GO:0060271	ciliary basal body;cilium assembly	None	None	26167768	Immunofluorescence studies showed that CFAP410 (C21orf2) co-localizes with NEK1 and SPATA7 at the basal body in hTERT-RPE1 cells.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cilia- and flagella-associated protein 410;Serine/threonine-protein kinase Nek1;Spermatogenesis-associated protein 7	CFAP410;NEK1;SPATA7	C21orf2,LRRC76;KIAA1901;HSD3
7868	MMP9-NEU1-TLR7 complex	Human	None	HEK-TLR7-HA cells	P14780;Q99519;Q9NYK1	4318;4758;51284	MI:0019-coimmunoprecipitation	GO:0006954;GO:0008063	inflammatory response;Toll signaling pathway	36.25.16.07	inflammatory response	23827939	NEU1 sialidase and matrix metalloproteinase-9 cross-talk regulates nucleic acid-induced endosomal TOLL-like receptor-7 and -9 activation, cellular signaling and pro-inflammatory responses.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Matrix metalloproteinase-9;Sialidase-1;Toll-like receptor 7	MMP9;NEU1;TLR7	CLG4B;NANH;None
7870	NGRN complex	Human	None	K562, HeLa, HEK293T cells	O95900;Q6P087;Q96CM3;Q96I51;Q9NPE2;Q9NYY8	26995;285367;84881;81554;51335;22868	MI:0007-anti tag coimmunoprecipitation	GO:0005739;GO:0006119;GO:0070129;GO:0019843	mitochondrion;oxidative phosphorylation;regulation of mitochondrial translation;rRNA binding	70.16	mitochondrion	27667664	The NGRN complex regulates the mitochondrial 16S rRNA and intra-mitochondrial translation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Pseudouridylate synthase TRUB2, mitochondrial;Mitochondrial mRNA pseudouridine synthase RPUSD3;Pseudouridylate synthase RPUSD4, mitochondrial;RCC1-like G exchanging factor-like protein;Neugrin;FAST kinase domain-containing protein 2, mitochondrial	TRUB2;RPUSD3;RPUSD4;RCC1L;NGRN;FASTKD2	None;None;None;WBSCR16;FI58G;KIAA0971
7871	NFE4-TFCP2 complex	Human	None	K562 cells	Q12800;Q86UQ8	7024;58160	MI:0007-anti tag coimmunoprecipitation;MI:0413-electrophoretic mobility shift assay	GO:0005634;GO:0006355	nucleus;regulation of DNA-templated transcription	70.10;11.02.03.04	nucleus;transcriptional control	7828600	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Alpha-globin transcription factor CP2;Transcription factor NF-E4	TFCP2;NFE4	LSF,SEF;None
7872	LYRM4-NFS1 complex	Human	ISD11-NFS1 complex	Escherichia coli	Q9HD34;Q9Y697	57128;9054	MI:0007-anti tag coimmunoprecipitation;MI:0107-surface plasmon resonance	GO:0006777;GO:0005737;GO:0016226	Mo-molybdopterin cofactor biosynthetic process;cytoplasm;iron-sulfur cluster assembly	70.03	cytoplasm	18650437	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	LYR motif-containing protein 4;Cysteine desulfurase, mitochondrial	LYRM4;NFS1	C6orf149 ISD11;NIFS
7873	EPM2A-NHLRC1 complex	Human	Laforin-malin complex	HEK293 cells	O95278;Q6VVB1	7957;378884	MI:0007-anti tag coimmunoprecipitation	GO:0031398;GO:0005980;GO:0005737;GO:1901800	positive regulation of protein ubiquitination;glycogen catabolic process;cytoplasm;positive regulation of proteasomal protein catabolic process	70.03	cytoplasm	24068615	Polyglucosan body (PB) formation is led by glycogen synthase (GS1). PBs degradation requires a protein assembly consisting of at least four key enzymes: laforin and malin in a complex, and the glycogenolytic enzymes, glycogen debranching enzyme 1 (AGL1) and brain isoform glycogen phosphorylase (GPBB).	In Lafora disease, the deficiency of either EPM2A or NHLRC1 causes massive accumulation of less-branched glycogen inclusions, known as Lafora bodies, also called polyglucosan bodies.	None	Homo sapiens (Human);Homo sapiens (Human)	Laforin;E3 ubiquitin-protein ligase NHLRC1	EPM2A;NHLRC1	None;EPM2B
7874	H/ACA ribonucleoprotein complex	Human	DKC1-GAR1-NHP2-NOP10 complex	HeLa cells	O60832;Q9NPE3;Q9NX24;Q9NY12	1736;55505;55651;54433	MI:0007-anti tag coimmunoprecipitation;MI:0416-fluorescence microscopy	GO:0005730;GO:0015030;GO:0031118	nucleolus;Cajal body;rRNA pseudouridine synthesis	70.10.07	nucleolus	11074001	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	H/ACA ribonucleoprotein complex subunit DKC1;H/ACA ribonucleoprotein complex subunit 3;H/ACA ribonucleoprotein complex subunit 2;H/ACA ribonucleoprotein complex subunit 1	DKC1;NOP10;NHP2;GAR1	NOLA4;NOLA3;NOLA2;NOLA1
7875	AUNIP-AURKA-NIN complex	Human	None	HeLa cells	O14965;Q8N4C6;Q9H7T9	6790;51199;79000	MI:0007-anti tag coimmunoprecipitation;MI:0416-fluorescence microscopy	GO:0090307	mitotic spindle assembly	None	None	20596670	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Aurora kinase A;Ninein;Aurora kinase A and ninein-interacting protein	AURKA;NIN;AUNIP	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6;KIAA1565;C1orf135
7876	NISCH-STK11 complex	Human	None	HEK293 cells	Q15831;Q9Y2I1	6794;11188	MI:0007-anti tag coimmunoprecipitation;MI:0416-fluorescence microscopy	GO:0005829;GO:0030010;GO:0006468	cytosol;establishment of cell polarity;protein phosphorylation	14.07.03	modification by phosphorylation, dephosphorylation, autophosphorylation	23572524	Cells expressing both Nischarin (NISCH) and LKB1 (STK11) have enhanced polarity, suggesting that they cooperatively regulate cell polarity.	Nischarin (NISCH) and LKB1 (STK11) cooperativly inhibit tumor cell migration. The absence of Nischarin and LKB1 led to a dramatic increase in the formation of lung metastases.	None	Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein kinase STK11;Nischarin	STK11;NISCH	LKB1 PJS;IRAS KIAA0975
7878	CHD7-NLK-PPARG-SETDB1 complex	Human	None	HeLa cells	P37231;Q15047;Q9P2D1;Q9UBE8	5468;9869;55636;None	MI:0007-anti tag coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0002051;GO:0005634;GO:0035567	osteoblast fate commitment;nucleus;non-canonical Wnt signaling pathway	70.10	nucleus	17952062	Suppression of PPARG function by cytokines in progenitor cells converts the cell fate of adipogenic precursors into osteoblastic cells.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Peroxisome proliferator-activated receptor gamma;Histone-lysine N-methyltransferase SETDB1;Chromodomain-helicase-DNA-binding protein 7;Serine/threonine-protein kinase NLK	PPARG;SETDB1;CHD7;NLK	NR1C3;ESET KIAA0067 KMT1E;KIAA1416;LAK1
7879	NLRP3-NLRC4 inflammasome	Human	CASP1-CASP8-ASC-NLRC4-NLRP3 inflammasome	HEK293 cells	P29466;Q14790;Q96P20;Q9NPP4;Q9ULZ3	834;841;114548;58484;29108	MI:0663-confocal microscopy	GO:0042742;GO:0002221;GO:0061702;GO:0045087;GO:0050727;GO:0032731;GO:0042981;GO:0140447	defense response to bacterium;pattern recognition receptor signaling pathway;inflammasome complex;innate immune response;regulation of inflammatory response;positive regulation of interleukin-1 beta production;regulation of apoptotic process;cytokine precursor processing	36.25.16.01	innate immune response (invertebrates and vertebrates)	24803432	Salmonella enterica serovar typhimurium simultaneously activates at least two NLRs, NLRC4 and NLRP3, resulting in the formation of the CASP1-CASP8-ASC-NLRC4-NLRC3 inflammasome that drives protective inflammatory responses in the host. In this complex ASC forms a large external ring with the NLRs (NLRP3, NLRC4) and caspases (CASP1, CASP8) located internally.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Caspase-1;Caspase-8;NACHT, LRR and PYD domains-containing protein 3;NLR family CARD domain-containing protein 4;Apoptosis-associated speck-like protein containing a CARD	CASP1;CASP8;NLRP3;NLRC4;PYCARD	IL1BC, IL1BCE;MCH5;C1orf7 CIAS1 NALP3 PYPAF1;CARD12 CLAN CLAN1 IPAF;ASC CARD5 TMS1
7880	DHX9-NLRP9-PYCARD complex	Human	None	HEK293 cells	Q08211;Q7RTR0;Q9ULZ3	1660;338321;29108	MI:0007-anti tag coimmunoprecipitation	GO:0051607;GO:0006954;GO:0045087;GO:0032741;GO:0070269	defense response to virus;inflammatory response;innate immune response;positive regulation of interleukin-18 production;pyroptosis	36.25.16.07;36.25.16.01	inflammatory response;innate immune response (invertebrates and vertebrates)	28636595	None	Rotavirus, a leading cause of severe gastroenteritis and diarrhoea in young children. Conditional depletion of Nlrp9b or other inflammasome components in the intestine in vivo resulted in enhanced susceptibility of mice to rotavirus replication.	It was proposed that CASP1 is also part of the protein complex but not experimentally shown.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	ATP-dependent RNA helicase A;NACHT, LRR and PYD domains-containing protein 9;Apoptosis-associated speck-like protein containing a CARD	DHX9;NLRP9;PYCARD	DDX9 LKP NDH2;NALP9 NOD6 PAN12;ASC CARD5 TMS1
7881	NMD3-RAN-XPO1 complex	Human	NMD3-RAN-CRM1 complex	HeLa cells	O14980;P62826;Q96D46	7514;5901;51068	MI:0007-anti tag coimmunoprecipitation	GO:0000055;GO:0005737;GO:0005634	ribosomal large subunit export from nucleus;cytoplasm;nucleus	70.03;70.10	cytoplasm;nucleus	12724356	NMD3 binds to XPO1 directly, in a RanGTP-dependent manner, by way of a C-terminal NES sequence. Results suggest that the functions of CRM1 and NMD3 in ribosomal subunit export are conserved from yeast to higher eukaryotes.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Exportin-1;GTP-binding nuclear protein Ran;60S ribosomal export protein NMD3	XPO1;RAN;NMD3	CRM1;ARA24;None
7882	BSG-JUP-NME1 complex	Human	EMMPRIN-gamma-catenin-Nm23 complex	HUVEC cells	P14923;P15531;P35613	3728;4830;682	MI:0019-coimmunoprecipitation;MI:0416-fluorescence microscopy;MI:0663-confocal microscopy	GO:0005911;GO:0031991	cell-cell junction;regulation of actomyosin contractile ring contraction	70.06.04	intercellular junction (gap junction/adherens junction)	24994937	The BSG-JUP-NME1 complex regulates actomyosin contractility at endothelial cell junctions through local ATP production	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Junction plakoglobin;Nucleoside diphosphate kinase A;Basigin	JUP;NME1;BSG	CTNNG DP3;NDPKA NM23;None
7883	MIF-NME1 complex	Human	MIF-NM23-H1 complex	HEK293 cells	P14174;P15531	4282;4830	MI:0007-anti tag coimmunoprecipitation	GO:0042981;GO:0051726	regulation of apoptotic process;regulation of cell cycle	10.03.01	mitotic cell cycle and cell cycle control	18815136	NME1 alleviated the MIF-mediated suppression of p53-induces apoptosis and cell cycle arrest by promoting the dissociation of MIF from MIF-p53 complexes. NME1 significantly inhibits the MIF-induced proliferation of quiescent NIH 3T3 cells through a direct interaction with MIF.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Macrophage migration inhibitory factor;Nucleoside diphosphate kinase A	MIF;NME1	GLIF MMIF;NDPKA NM23
7884	ANP32A-APEX1-HMG2-NME1-SET complex	Human	None	Jurkat cells	P15531;P26583;P27695;P39687;Q01105	4830;3148;328;8125;6418	MI:0007-anti tag coimmunoprecipitation;MI:0071-molecular sieving	GO:0006915;GO:0006304	apoptotic process;DNA modification	40.10.02;10.01.09	apoptosis (type I programmed cell death);DNA restriction or modification	12628186	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Nucleoside diphosphate kinase A;High mobility group protein B2;DNA-(apurinic or apyrimidinic site) endonuclease;Acidic leucine-rich nuclear phosphoprotein 32 family member A;Protein SET	NME1;HMGB2;APEX1;ANP32A;SET	NDPKA NM23;HMG2;APE APE1 APEX APX HAP1 REF1;C15orf1 LANP MAPM PHAP1;None
7885	NLRP1-NOD2 inflammasome	Human	NLRP1-NOD2-CASP1 inflammasome	HEK293 cells	P29466;Q9C000;Q9HC29	834;22861;64127	MI:0019-coimmunoprecipitation;MI:0071-molecular sieving	GO:0061702;GO:0032731;GO:0050729;GO:0045087;GO:0002221;GO:0042742;GO:0140447	inflammasome complex;positive regulation of interleukin-1 beta production;positive regulation of inflammatory response;innate immune response;pattern recognition receptor signaling pathway;defense response to bacterium;cytokine precursor processing	36.25.16.01	innate immune response (invertebrates and vertebrates)	18511561	The CASP1-NLRP1-NOD2 inflammasome mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Caspase-1;NACHT, LRR and PYD domains-containing protein 1;Nucleotide-binding oligomerization domain-containing protein 2	CASP1;NLRP1;NOD2	IL1BC, IL1BCE;CARD7 DEFCAP KIAA0926 NAC NALP1;CARD15 IBD1
7886	NOX1-NOXA1-NOXO1-RAC1 complex	Human	None	HEK293 cells	P63000;Q86UR1;Q8NFA2;Q9Y5S8	5879;10811;124056;27035	MI:0007-anti tag coimmunoprecipitation	GO:1903409	reactive oxygen species biosynthetic process	None	None	16636067	In reconstitution studies using transfected cells, co-expression of NOX1, NOXO1, and NOXA1 results in the production of relatively high levels of reactive oxygen.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Ras-related C3 botulinum toxin substrate 1;NADPH oxidase activator 1;NADPH oxidase organizer 1;NADPH oxidase 1	RAC1;NOXA1;NOXO1;NOX1	TC25;P51NOX;P41NOX SH3PXD5;MOX1 NOH1
7887	NLRP6 inflammasome	Human	CASP1-NLRP6-PYCARD inflammasome complex	HEK293 cells	P29466;P59044;Q9ULZ3	834;171389;29108	MI:0007-anti tag coimmunoprecipitation	GO:0009617;GO:0045087;GO:0032741;GO:0002221;GO:0061702;GO:0050727;GO:0044403;GO:0010033	response to bacterium;innate immune response;positive regulation of interleukin-18 production;pattern recognition receptor signaling pathway;inflammasome complex;regulation of inflammatory response;biological process involved in symbiotic interaction;response to organic substance	36.25.16.01	innate immune response (invertebrates and vertebrates)	26638072	Microbiota-modulated metabolites drive NLRP6 inflammasome activation and downstream epithelial IL-18-induced AMP secretion, thereby providing favorable conditions for wild-type microbiota colonization. Distortion of this balanced AMP landscape by inflammasome deficiency drives dysbiosis development. (PMID:26638072)	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Caspase-1;NACHT, LRR and PYD domains-containing protein 6;Apoptosis-associated speck-like protein containing a CARD	CASP1;NLRP6;PYCARD	IL1BC, IL1BCE;NALP6,PYPAF5;ASC CARD5 TMS1
7888	NLRP7 inflammasome	Human	CASP1-NLRP7-PYCARD complex	HEK293 cells	P29466;Q8WX94;Q9ULZ3	834;199713;29108	MI:0007-anti tag coimmunoprecipitation;MI:0071-molecular sieving;MI:0416-fluorescence microscopy	GO:0061702;GO:0045087;GO:0002221;GO:0050727;GO:0032731;GO:0032741;GO:0042742;GO:0140447	inflammasome complex;innate immune response;pattern recognition receptor signaling pathway;regulation of inflammatory response;positive regulation of interleukin-1 beta production;positive regulation of interleukin-18 production;defense response to bacterium;cytokine precursor processing	36.25.16.01	innate immune response (invertebrates and vertebrates)	22361007	The NLRP7 inflammasome is induced in response to microbial acylated lipopeptides and promotes caspase-1-dependent IL-1beta and IL-18 maturation in human macrophages to restrict bacterial replication.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Caspase-1;NACHT, LRR and PYD domains-containing protein 7;Apoptosis-associated speck-like protein containing a CARD	CASP1;NLRP7;PYCARD	IL1BC, IL1BCE;NALP7 NOD12 PYPAF3;ASC CARD5 TMS1
7889	AIM2 inflammasome	Human	AIM2-PYCARD inflammasome complex; AIM2-ASC complex	HEK293 cells	O14862;P29466;Q9ULZ3	9447;834;29108	MI:0007-anti tag coimmunoprecipitation	GO:0061702;GO:0051607;GO:0045087;GO:1990784;GO:0042742;GO:0002221;GO:0032731;GO:0140447;GO:0140639	inflammasome complex;defense response to virus;innate immune response;response to dsDNA;defense response to bacterium;pattern recognition receptor signaling pathway;positive regulation of interleukin-1 beta production;cytokine precursor processing;positive regulation of pyroptosis	36.25.16.01	innate immune response (invertebrates and vertebrates)	19158676	AIM2 is a receptor for cytosolic dsDNA, which forms a new inflammasome complex with ASC to activate caspase-1-mediated processing of IL1b. (PMID:19158676)	Data indicate that the activation of the AIM2 inflammasome is important in innate immunity to vaccinia virus.	The complex presumably also contains CASP1, but this interaction was not shown experimentally (PMID:19158676). The ternary complex has been reconstituted in vitro (PMID:24630722).	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Interferon-inducible protein AIM2;Caspase-1;Apoptosis-associated speck-like protein containing a CARD	AIM2;CASP1;PYCARD	None;IL1BC, IL1BCE;ASC CARD5 TMS1
7890	HRAS-IRAK1-IRAK2-TRAF6 complex	Human	None	HeLa cells	O43187;P01112;P51617;Q9Y4K3	3656;3265;3654;7189	MI:0007-anti tag coimmunoprecipitation	None	None	None	None	11744690	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Interleukin-1 receptor-associated kinase-like 2;GTPase HRas;Interleukin-1 receptor-associated kinase 1;TNF receptor-associated factor 6	IRAK2;HRAS;IRAK1;TRAF6	None;HRAS1;IRAK;RNF85
7892	AIM2 inflammasome (CASP8)	Human	AIM2-CASP8-PYCARD complex; AIM2-ASC-CASP8 complex	HEK293 cells	O14862;Q14790;Q9ULZ3	9447;841;29108	MI:0019-coimmunoprecipitation;MI:0416-fluorescence microscopy	GO:0045087;GO:0005829;GO:0042742;GO:0002221;GO:0061702;GO:0050727;GO:0032731;GO:0042981;GO:1990784;GO:0140447	innate immune response;cytosol;defense response to bacterium;pattern recognition receptor signaling pathway;inflammasome complex;regulation of inflammatory response;positive regulation of interleukin-1 beta production;regulation of apoptotic process;response to dsDNA;cytokine precursor processing	36.25.16.01	innate immune response (invertebrates and vertebrates)	22555457	AIM2 triggers PYCARD (ASC)-dependent, caspase-1-independent cell death upon Francisella infection or DNA delivery into the cytosol. Absence of caspase-1 switches AIM2/ASC-mediated death from pyroptosis to caspase-8-mediated apoptosis.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Interferon-inducible protein AIM2;Caspase-8;Apoptosis-associated speck-like protein containing a CARD	AIM2;CASP8;PYCARD	None;MCH5;ASC CARD5 TMS1
7893	DDX58-PYCARD complex	Human	RIG-I-ASC complex; ASC-RIG-I complex	THP-1 human monocytic cells	O95786;Q9ULZ3	23586;29108	MI:0019-coimmunoprecipitation	GO:0045087;GO:0002221;GO:0039529;GO:0051607;GO:0050729;GO:0032732;GO:0140632	innate immune response;pattern recognition receptor signaling pathway;RIG-I signaling pathway;defense response to virus;positive regulation of inflammatory response;positive regulation of interleukin-1 production;inflammasome complex assembly	36.25.16.01	innate immune response (invertebrates and vertebrates)	19915568	Recognition of RNA virus by RIG-I (DDX58) results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production.  The viruses recognized by RIG-I include vesicular stomatitis virus (VSV) and influenza virus.	None	The complex presumably also contains CASP1 but this has not been shown experimentally.	Homo sapiens (Human);Homo sapiens (Human)	Antiviral innate immune response receptor RIG-I;Apoptosis-associated speck-like protein containing a CARD	DDX58;PYCARD	None;ASC CARD5 TMS1
7894	MECOM-CEBPB complex	Human	CEBPB-EVI1 complex	HEK293 cells	P17676;Q03112	1051;2122	MI:0019-coimmunoprecipitation	GO:0045444;GO:0006355;GO:0005634	fat cell differentiation;regulation of DNA-templated transcription;nucleus	11.02.03.04;70.10	transcriptional control;nucleus	22473998	MECOM (Evi1) expression converts nonadipogenic cells into adipocytes via an increase in the predifferentiation levels of PPARgamma2, the adipose-selective isoform of PPARgamma.	None	None	Homo sapiens (Human);Homo sapiens (Human)	CCAAT/enhancer-binding protein beta;Histone-lysine N-methyltransferase MECOM	CEBPB;MECOM	TCF5;EVI1 MDS1 PRDM3
7895	MECOM-SUV39H1 complex	Human	EVI1-SUV39H1 complex	phoenix E cells	O43463;Q03112	6839;2122	MI:0007-anti tag coimmunoprecipitation;MI:0416-fluorescence microscopy	GO:0045892;GO:0046974	negative regulation of DNA-templated transcription;histone methyltransferase activity (H3-K9 specific)	11.02.03.04.03	transcription repression	18619962	SUV39H1, through its SET domain, cooperates with MECOM in vivo and enhances the transcriptional repression activity of MECOM in a dose dependent manner.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Histone-lysine N-methyltransferase SUV39H1;Histone-lysine N-methyltransferase MECOM	SUV39H1;MECOM	KMT1A, SUV39H;EVI1 MDS1 PRDM3
7896	EHMT2-MECOM complex	Human	EVI1-G9A complex; G9A-MECOM complex	phoenix E cells	Q03112;Q96KQ7	2122;10919	MI:0007-anti tag coimmunoprecipitation	GO:0046974	histone methyltransferase activity (H3-K9 specific)	None	None	18619962	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Histone-lysine N-methyltransferase MECOM;Histone-lysine N-methyltransferase EHMT2	MECOM;EHMT2	EVI1 MDS1 PRDM3;BAT8 C6orf30 G9A KMT1C NG36
7897	IFI16 inflammasome	Human	CASP1-IFI16-PYCARD inflammasome complex	KSHV-Infected HMVEC-d cells	P29466;Q16666;Q9ULZ3	834;3428;29108	MI:0019-coimmunoprecipitation;MI:0416-fluorescence microscopy	GO:0050729;GO:0005634;GO:0051607;GO:0002221;GO:0045087;GO:0061702;GO:0032731;GO:0140447	positive regulation of inflammatory response;nucleus;defense response to virus;pattern recognition receptor signaling pathway;innate immune response;inflammasome complex;positive regulation of interleukin-1 beta production;cytokine precursor processing	70.10;36.25.16.01	nucleus;innate immune response (invertebrates and vertebrates)	21575908	During Kaposi Sarcoma-Associated Herpesvirus (KSHV) infection of endothelial cells, interferon gamma-inducible protein 16 (IFI16) interacts with the adaptor molecule ASC and CASP1 (procaspase-1) to form a functional inflammasome. Unlike most inflammasomes, the CASP1-IFI16-PYCARD inflammasome complex is initially located in the nucleus.	The CASP1-IFI16-PYCARD inflammasome complex is formed in response to Kaposi sarcoma-associated herpesvirus infections.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Caspase-1;Gamma-interferon-inducible protein 16;Apoptosis-associated speck-like protein containing a CARD	CASP1;IFI16;PYCARD	IL1BC, IL1BCE;IFNGIP1;ASC CARD5 TMS1
7898	NADPH oxidase, cytosolic subcomplex	Human	NCF1-NCF2-NCF4 comnplex	vascular smooth muscle cells	P14598;P19878;Q15080	653361;4688;4689	MI:0019-coimmunoprecipitation	GO:0005737	cytoplasm	70.03	cytoplasm	12065324	Under unstimulated conditions, the multidomain regulatory subunits, NCF1, NCF2 and NCF4, exist in the cytosol as a complex. Upon stimulation, NCF1 (p47phox) undergoes phosphorylation, and the entire complex subsequently translocates to the membrane and associates with cyt b558 (CYBA and CYBB) to form the active oxidase	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Neutrophil cytosol factor 1;Neutrophil cytosol factor 2;Neutrophil cytosol factor 4	NCF1;NCF2;NCF4	NOXO2 SH3PXD1A;NOXA2 P67PHOX;SH3PXD4
7899	NADPH oxidase	Human	CYBA-CYBB-NCF1-NCF2 complex	vascular smooth muscle cells	P04839;P13498;P14598;P19878	1536;1535;653361;4688	MI:0019-coimmunoprecipitation;MI:0416-fluorescence microscopy	GO:0042554;GO:0043020	superoxide anion generation;NADPH oxidase complex	None	None	12065324	Under unstimulated conditions, the multidomain regulatory subunits, NCF1, NCF2 and NCF4, exist in the cytosol as a complex. Upon stimulation, NCF1 (p47phox) undergoes phosphorylation, and the entire complex subsequently translocates to the membrane and associates with cyt b558 (CYBA and CYBB) to form the active oxidase.	None	The complex presumably also contains NCF4, but this was not experimentally shown.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cytochrome b-245 heavy chain;Cytochrome b-245 light chain;Neutrophil cytosol factor 1;Neutrophil cytosol factor 2	CYBB;CYBA;NCF1;NCF2	NOX2;None;NOXO2 SH3PXD1A;NOXA2 P67PHOX
7900	NEK7-NLRP3 inflammasome	Human	NEK7-NLRP3-PYCARD-CASP1 complex; ASC-CASP1-NEK7-NLRP3 complex	HEK293 cells, stimulated with LPS	P29466;Q8TDX7;Q96P20;Q9ULZ3	834;140609;114548;29108	MI:0007-anti tag coimmunoprecipitation	GO:0061702;GO:0045087;GO:0002221;GO:0032731;GO:0072559;GO:0050727;GO:0032496;GO:0051726;GO:0006952;GO:0140447	inflammasome complex;innate immune response;pattern recognition receptor signaling pathway;positive regulation of interleukin-1 beta production;NLRP3 inflammasome complex;regulation of inflammatory response;response to lipopolysaccharide;regulation of cell cycle;defense response;cytokine precursor processing	36.25.16.01;10.03.01	innate immune response (invertebrates and vertebrates);mitotic cell cycle and cell cycle control	26642356	Activation of the NLRP3 inflammasome requires NEK7 and is restricted to the interphase of the cell cycle by NEK7. This suggests, that NEK7 is a component of the NLRP3 inflammasome and acts as a switch between mitosis and competence for inflammasome activation. (PMID:26642356)	None	Pro-caspase-1 is also part of the complex, but this was not shown experimentally.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Caspase-1;Serine/threonine-protein kinase Nek7;NACHT, LRR and PYD domains-containing protein 3;Apoptosis-associated speck-like protein containing a CARD	CASP1;NEK7;NLRP3;PYCARD	IL1BC, IL1BCE;None;C1orf7 CIAS1 NALP3 PYPAF1;ASC CARD5 TMS1
7901	DPP9-NLRP1 complex	Human	None	None	Q86TI2;Q9C000	91039;22861	MI:0040-electron microscopy	GO:0050727;GO:0045824	regulation of inflammatory response;negative regulation of innate immune response	None	None	33731932	NLRP1 is an inflammasome sensor that mediates the activation of caspase-1 to induce cytokine maturation and pyroptosis. Cytosolic dipeptidyl peptidases 8 and 9 (DPP8/DPP9) both interact with NLRP1, and small-molecule inhibitors of DPP8/DPP9 activate NLRP1 by mechanisms that are currently unclear .	None	None	Homo sapiens (Human);Homo sapiens (Human)	Dipeptidyl peptidase 9;NACHT, LRR and PYD domains-containing protein 1	DPP9;NLRP1	DPRP2;CARD7 DEFCAP KIAA0926 NAC NALP1
7902	BCL10-CARD9-CASP8-MALT1-PYCARD inflammasome complex	Human	CARD9-BCL10-MALT1-ASC-CASP8 inflammasome complex	Dendritic cells, stimulated with dectin-1 agonist curdlan	O95999;Q14790;Q9H257;Q9UDY8;Q9ULZ3	8915;841;64170;10892;29108	MI:0019-coimmunoprecipitation	GO:0061702;GO:0045087;GO:0002223;GO:0002221;GO:0050727;GO:0032731;GO:0050832;GO:0140447	inflammasome complex;innate immune response;stimulatory C-type lectin receptor signaling pathway;pattern recognition receptor signaling pathway;regulation of inflammatory response;positive regulation of interleukin-1 beta production;defense response to fungus;cytokine precursor processing	36.25.16.01	innate immune response (invertebrates and vertebrates)	22267217	Binding of the extracellular sensor dectin-1 to pathogens triggered the formation and activation of a noncanonical inflammasome complex consisting of CARD9, Bcl-10, MALT1, caspase-8 and ASC, which processed pro-IL-1beta into mature, bioactive IL-1beta.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	B-cell lymphoma/leukemia 10;Caspase-8;Caspase recruitment domain-containing protein 9;Mucosa-associated lymphoid tissue lymphoma translocation protein 1;Apoptosis-associated speck-like protein containing a CARD	BCL10;CASP8;CARD9;MALT1;PYCARD	CIPER, CLAP;MCH5;None;MLT;ASC CARD5 TMS1
7903	MALT1-ASC-CASP8 inflammasome	Human	MALT1-CASP8-PYCARD complex; CASP8-MALT1-PYCARD complex	Dendritic cells, stimulated with dectin-1 agonist curdlan	Q14790;Q9UDY8;Q9ULZ3	841;10892;29108	MI:0019-coimmunoprecipitation	GO:0050832;GO:0061702;GO:0045087;GO:0002221;GO:0032731;GO:0050727;GO:0002223;GO:0140447	defense response to fungus;inflammasome complex;innate immune response;pattern recognition receptor signaling pathway;positive regulation of interleukin-1 beta production;regulation of inflammatory response;stimulatory C-type lectin receptor signaling pathway;cytokine precursor processing	36.25.16.01	innate immune response (invertebrates and vertebrates)	22267217	Whereas the CARD9\u2013Bcl-10\u2013MALT1 scaffold directs IL1B transcription as response to pathogens, the recruitment of MALT1\u2013caspase-8 and PYCARD (ASC) into this scaffold was crucial for processing of pro-IL-1b by caspase-8.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Caspase-8;Mucosa-associated lymphoid tissue lymphoma translocation protein 1;Apoptosis-associated speck-like protein containing a CARD	CASP8;MALT1;PYCARD	MCH5;MLT;ASC CARD5 TMS1
7904	IQGAP1-NLRC3 complex	Human	None	HEK293T cells	P46940;Q7RTR2	8826;197358	MI:0007-anti tag coimmunoprecipitation	GO:0051607;GO:0032481;GO:0005737	defense response to virus;positive regulation of type I interferon production;cytoplasm	70.03	cytoplasm	28864474	NLRC3 negatively regulates the type I IFN pathway by inhibiting subcellular redistribution and effective signaling of STING. IQGAP1 associates with NLRC3 and can disrupt the NLRC3\u2013STING interaction in the cytosol of human epithelial cells.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Ras GTPase-activating-like protein IQGAP1;NLR family CARD domain-containing protein 3	IQGAP1;NLRC3	KIAA0051;NOD3
7905	NAIP-NLRC4 inflammasome	Human	NAIP-NLRC4-CASP1 complex	HEK293 cells	P29466;Q13075;Q9NPP4	834;4671;58484	MI:0045-experimental interaction detection;MI:0276-blue native page	GO:0061702;GO:0045087;GO:0002221;GO:0042742;GO:0032731;GO:0050727;GO:0140639	inflammasome complex;innate immune response;pattern recognition receptor signaling pathway;defense response to bacterium;positive regulation of interleukin-1 beta production;regulation of inflammatory response;positive regulation of pyroptosis	36.25.16.01	innate immune response (invertebrates and vertebrates)	23940371	NAIP mediates recognition of bacterial T3SS needle proteins to stimulate NLRC4 inflammasome activation. For all of the five needle proteins assayed, hNAIP knock-down reduced caspase-1 activation   (PMID: 23940371). NLRC4 is able to directly interact with and activate pro-Caspase-1 independently of ASC (PYCARD). Nevertheless, ASC greatly enhances the efficiency of NLRC4-mediated cytokine processing (PMID: 21147462, 20603313). The NLRC4 inflammasome plays an important role in facilitating the clearance of bacterial enteric pathogens (PMID:29247997).	None	Inflammasome reconstitution assay showed that pro-Casp1 is an essential subunit of the inflammasome complex.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Caspase-1;Baculoviral IAP repeat-containing protein 1;NLR family CARD domain-containing protein 4	CASP1;NAIP;NLRC4	IL1BC, IL1BCE;BIRC1;CARD12 CLAN CLAN1 IPAF
7909	NLRP12 inflammasome	Human	CASP1-NLRP12-PYCARD inflammasome complex	HEK293T cells	P29466;P59046;Q9ULZ3	834;91662;29108	MI:0397-two hybrid array;MI:0416-fluorescence microscopy	GO:0061702;GO:0070269;GO:0002221;GO:0045087;GO:0050729;GO:0032731;GO:0051092;GO:0006952;GO:0140447	inflammasome complex;pyroptosis;pattern recognition receptor signaling pathway;innate immune response;positive regulation of inflammatory response;positive regulation of interleukin-1 beta production;positive regulation of NF-kappaB transcription factor activity;defense response;cytokine precursor processing	36.25.16.01	innate immune response (invertebrates and vertebrates)	12019269	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Caspase-1;NACHT, LRR and PYD domains-containing protein 12;Apoptosis-associated speck-like protein containing a CARD	CASP1;NLRP12;PYCARD	IL1BC, IL1BCE;NALP12 PYPAF7 RNO;ASC CARD5 TMS1
7910	BAG2-HSPA2-NLRP14 complex	Human	None	HEK293FT cells	O95816;P54652;Q86W24	9532;3306;338323	MI:0007-anti tag coimmunoprecipitation	GO:0007283;GO:0010498	spermatogenesis;proteasomal protein catabolic process	None	None	32839316	In male mice, Nlrp14 knockout strongly compromised differentiation of spermatogonial stem cells and meiosis. Mechanistically, NLRP14 protected HSPA2 from proteasome-mediated degradation by recruiting BAG2.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	BAG family molecular chaperone regulator 2;Heat shock-related 70 kDa protein 2;NACHT, LRR and PYD domains-containing protein 14	BAG2;HSPA2;NLRP14	None;None;NALP14 NOD5
7911	NADPH oxidase	Human	None	endothelial cells	P04839;P13498;P14598;P19878;P63000;Q15080	1536;1535;653361;4688;5879;4689	MI:0019-coimmunoprecipitation;MI:0416-fluorescence microscopy	GO:0043020	NADPH oxidase complex	None	None	11893732	NADPH oxidase is assembled from a membrane-spanning flavocytochrome b 558, composed of Nox2 (also called gp91phox) and p22phox and four cytosolic factors (p47phox, p67phox, p40phox, and Rac)	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cytochrome b-245 heavy chain;Cytochrome b-245 light chain;Neutrophil cytosol factor 1;Neutrophil cytosol factor 2;Ras-related C3 botulinum toxin substrate 1;Neutrophil cytosol factor 4	CYBB;CYBA;NCF1;NCF2;RAC1;NCF4	NOX2;None;NOXO2 SH3PXD1A;NOXA2 P67PHOX;TC25;SH3PXD4
7913	NONO-NR5A1 complex	Human	NONO-SP1 complex	H295R adrenocortical cells	Q13285;Q15233	2516;4841	MI:0019-coimmunoprecipitation;MI:0413-electrophoretic mobility shift assay	GO:0006355;GO:0006694	regulation of DNA-templated transcription;steroid biosynthetic process	11.02.03.04;01.06.06.11	transcriptional control;tetracyclic and pentacyclic triterpenes (cholesterin, steroids and hopanoids) metabolism	11897684	The first 57 bp upstream of the transcription initiation site of the human CYP17 gene are essential for both basal and cAMP-dependent transcription. EMSA showed the formation of three DNA-protein complexes involved in CYP17 gene regulation. The fastest complex contained NR5A1 (SF-1) and NONO, the intermediate complex contained NONO and SFPQ, and the slowest complex contained the NONO-NR5A1-SFPQ complex.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Steroidogenic factor 1;Non-POU domain-containing octamer-binding protein	NR5A1;NONO	AD4BP, FTZF1, SF1;NRB54
7914	NONO-SFPQ complex	Human	NONO-PSF complex	H295R adrenocortical cells	P23246;Q15233	6421;4841	MI:0019-coimmunoprecipitation;MI:0413-electrophoretic mobility shift assay	GO:0006355;GO:0006694	regulation of DNA-templated transcription;steroid biosynthetic process	11.02.03.04;01.06.06.11	transcriptional control;tetracyclic and pentacyclic triterpenes (cholesterin, steroids and hopanoids) metabolism	11897684	The first 57 bp upstream of the transcription initiation site of the human CYP17 gene are essential for both basal and cAMP-dependent transcription. EMSA showed the formation of three DNA-protein complexes involved in CYP17 gene regulation. The fastest complex contained NR5A1 (SF-1) and NONO, the intermediate complex contained NONO and SFPQ, and the slowest complex contained the NONO-NR5A1-SFPQ complex.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Splicing factor, proline- and glutamine-rich;Non-POU domain-containing octamer-binding protein	SFPQ;NONO	PSF;NRB54
7915	NONO-NR5A1-SFPQ complex	Human	NONO-PSF-SF1 complex	H295R adrenocortical cells	P23246;Q13285;Q15233	6421;2516;4841	MI:0019-coimmunoprecipitation;MI:0413-electrophoretic mobility shift assay	GO:0006355;GO:0006694	regulation of DNA-templated transcription;steroid biosynthetic process	11.02.03.04;01.06.06.11	transcriptional control;tetracyclic and pentacyclic triterpenes (cholesterin, steroids and hopanoids) metabolism	11897684	The first 57 bp upstream of the transcription initiation site of the human CYP17 gene are essential for both basal and cAMP-dependent transcription. EMSA showed the formation of three DNA-protein complexes involved in CYP17 gene regulation. The fastest complex contained NR5A1 (SF-1) and NONO, the intermediate complex contained NONO and SFPQ, and the slowest complex contained the NONO-NR5A1-SFPQ complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Splicing factor, proline- and glutamine-rich;Steroidogenic factor 1;Non-POU domain-containing octamer-binding protein	SFPQ;NR5A1;NONO	PSF;AD4BP, FTZF1, SF1;NRB54
7916	ILF3-NR5A2-PPARA-PRMT1 complex	Human	None	HEK293 cells	O00482;Q07869;Q12906;Q99873	2494;5465;3609;3276	MI:0402-chromatin immunoprecipitation assay	GO:0006699;GO:0006695;GO:0006355	bile acid biosynthetic process;cholesterol biosynthetic process;regulation of DNA-templated transcription	11.02.03.04	transcriptional control	21554248	ILF3 functions as a novel NR5A2 (LRH-1) co-activator by acting synergistically with PRMT1 and PPARA (PGC-1alpha), thereby promoting LRH-1-dependent gene expression. LRH-1 regulates the expression of its target genes, which are involved in bile acid and cholesterol homoeostasis.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Nuclear receptor subfamily 5 group A member 2;Peroxisome proliferator-activated receptor alpha;Interleukin enhancer-binding factor 3;Protein arginine N-methyltransferase 1	NR5A2;PPARA;ILF3;PRMT1	B1F CPF FTF;NR1C1 PPAR;DRBF MPHOSPH4 NF90;HMT2 HRMT1L2 IR1B4
7919	ILF3-NR5A2-SERBP1 complex	Human	ILF3-LRH1-SERBP1 complex	Huh7 cells	O00482;Q12906;Q8NC51	2494;3609;26135	MI:0019-coimmunoprecipitation	GO:0006351;GO:0005634	DNA-templated transcription;nucleus	11;70.10	TRANSCRIPTION;nucleus	26398198	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Nuclear receptor subfamily 5 group A member 2;Interleukin enhancer-binding factor 3;Plasminogen activator inhibitor 1 RNA-binding protein	NR5A2;ILF3;SERBP1	B1F CPF FTF;DRBF MPHOSPH4 NF90;PAIRBP1
7920	IGFBP3-NONO-SFPQ complex	Human	None	MDA-MB-468 cells; HCC1806 cells	P17936;P23246;Q15233	3486;6421;4841	MI:0019-coimmunoprecipitation;MI:0416-fluorescence microscopy	GO:0006303;GO:0005634	double-strand break repair via nonhomologous end joining;nucleus	70.10	nucleus	30725116	The IGFBP3-NONO-SFPQ complex modulates DSB repair by non-homologous end-joining in triple-negative breast cancer cells.	IGFBP-3 interacts with NONO and SFPQ in PARP-dependent DNA damage repair in triple?negative breast cancer	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Insulin-like growth factor-binding protein 3;Splicing factor, proline- and glutamine-rich;Non-POU domain-containing octamer-binding protein	IGFBP3;SFPQ;NONO	IBP3;PSF;NRB54
7924	ACE2-TMPRSS2 complex	Human	None	293T cells	O15393;Q9BYF1	7113;59272	MI:0019-coimmunoprecipitation	GO:0046718	viral entry into host cell	None	None	21068237	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Transmembrane protease serine 2;Angiotensin-converting enzyme 2	TMPRSS2;ACE2	PRSS10;None
7925	ACE2-SLC6A19 complex	Human	ACE2-B0AT1 complex	HEK 293F cells	Q695T7;Q9BYF1	340024;59272	MI:0040-electron microscopy;MI:0071-molecular sieving	GO:0006865	amino acid transport	20.01.07	amino acid/amino acid derivatives transport	32132184	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Sodium-dependent neutral amino acid transporter B(0)AT1;Angiotensin-converting enzyme 2	SLC6A19;ACE2	B0AT1;None
7926	AGTR2-MAS1 complex	Human	AT2R-MAS1 complex	HEK 293 cells	P04201;P50052	4142;186	MI:0055-fluorescent resonance energy transfer	GO:0008217	regulation of blood pressure	None	None	28461604	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Proto-oncogene Mas;Type-2 angiotensin II receptor	MAS1;AGTR2	MAS;None
7927	AGTR1-AGTR2 complex	Human	AT1R-AT2R complex	myometrium	P30556;P50052	185;186	MI:0091-chromatography technology	GO:0038166	angiotensin-activated signaling pathway	None	None	11507095	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Type-1 angiotensin II receptor;Type-2 angiotensin II receptor	AGTR1;AGTR2	AGTR1A AGTR1B AT2R1 AT2R1B;None
7928	BDKRB2-MAS1 receptor	Human	B2R-MASR heterodimer	HEK293T	P04201;P30411	4142;624	MI:0055-fluorescent resonance energy transfer	GO:0008283;GO:0050482	cell population proliferation;arachidonic acid secretion	None	None	27550920	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Proto-oncogene Mas;B2 bradykinin receptor	MAS1;BDKRB2	MAS;BKR2
7930	RAB8A-SYTL4 complex	Human	RAB8-SLP4 complex	HEK293T cells	P61006;Q96C24	4218;94121	MI:0004-affinity chromatography technology;MI:0019-coimmunoprecipitation	GO:0002576	platelet degranulation	None	None	23140275	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Ras-related protein Rab-8A;Synaptotagmin-like protein 4	RAB8A;SYTL4	MEL RAB8;None
7932	ERBB3-ITGA6-ITGB4-NRG1 complex	Human	None	MCF-7 cells	P16144;P21860;P23229;Q02297	3691;2065;3655;3084	MI:0019-coimmunoprecipitation	GO:0007229	integrin-mediated signaling pathway	30.05.02.26	integrin receptor signalling pathway	20682778	None	Integrin alpha6-beta4 is a receptor for the laminin family of extracellular matrix proteins, and its expression is associated with poor patient prognosis and reduced survival in a variety of human cancers.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-4;Receptor tyrosine-protein kinase erbB-3;Integrin alpha-6;Pro-neuregulin-1, membrane-bound isoform	ITGB4;ERBB3;ITGA6;NRG1	None;HER3;None;GGF HGL HRGA NDF SMDF
7933	ERBB3-ITGAV-ITGB3-NRG1 complex	Human	None	MCF-7 cells	P05106;P06756;P21860;Q02297	3690;3685;2065;3084	MI:0019-coimmunoprecipitation	GO:0007229	integrin-mediated signaling pathway	30.05.02.26	integrin receptor signalling pathway	20682778	None	There is a positive correlation between ITGAV-ITGB3 integrin levels and overexpression of NRG associated with melanoma tumor progression and metastasis.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-3;Integrin alpha-V;Receptor tyrosine-protein kinase erbB-3;Pro-neuregulin-1, membrane-bound isoform	ITGB3;ITGAV;ERBB3;NRG1	GP3A;MSK8 VNRA VTNR;HER3;GGF HGL HRGA NDF SMDF
7934	GTF2I-PARP1-SFPQ complex	Human	None	SH-SY5Y cells	P09874;P23246;P78347	142;6421;2969	MI:0413-electrophoretic mobility shift assay	GO:0001764;GO:0005634	neuron migration;nucleus	70.10	nucleus	20682778	None	The GTF2I-PARP1-SFPQ complex regulates the DYX1C1 gene implicated in neuronal migration and dyslexia.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Poly [ADP-ribose] polymerase 1;Splicing factor, proline- and glutamine-rich;General transcription factor II-I	PARP1;SFPQ;GTF2I	ADPRT PPOL;PSF;BAP135 WBSCR6
7935	Renin-PRR complex	Human	REN-ATP6AP2 complex	fetal mesangial cell line (HMC)	O75787;P00797	10159;5972	MI:0019-coimmunoprecipitation	GO:0002016;GO:0002018;GO:0070371	regulation of blood volume by renin-angiotensin;renin-angiotensin regulation of aldosterone production;ERK1 and ERK2 cascade	None	None	12045255	The receptor N14F (ATP6AP2) binds renin, but also pro-renin. The amount of Ang I generated by receptor-bound (pro)renin was much higher than that by renin in solution. PMID: 12045255	None	None	Homo sapiens (Human);Homo sapiens (Human)	Renin receptor;Renin	ATP6AP2;REN	ATP6IP2 CAPER ELDF10;None
7936	PSO4 complex	Human	None	HeLa nuclear extract	O43660;O75934;Q99459;Q9UMS4	5356;10286;988;27339	MI:0096-pull down	GO:0006397;GO:0005634	mRNA processing;nucleus	11.04.03;70.10	mRNA processing (splicing, 5'-, 3'-end processing);nucleus	16223718	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Pleiotropic regulator 1;Pre-mRNA-splicing factor SPF27;Cell division cycle 5-like protein;Pre-mRNA-processing factor 19	PLRG1;BCAS2;CDC5L;PRPF19	None;DAM1;KIAA0432 PCDC5RP;NMP200 PRP19 SNEV
7937	PSO4-WRN complex	Human	None	HeLa nuclear extract	O43660;O75934;Q14191;Q99459;Q9UMS4	5356;10286;7486;988;27339	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0005634;GO:0036297	nucleus;interstrand cross-link repair	70.10	nucleus	16223718	The DNA helicase function of WRN is required for DNA interstrand cross-link (ICL) processing in vitro.	Mutations in the RECQL2 gene cause Werner syndrome.	WRN directly co-immunoprecipitated with Cdc5L subunit of the Pso4 complex.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Pleiotropic regulator 1;Pre-mRNA-splicing factor SPF27;Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN;Cell division cycle 5-like protein;Pre-mRNA-processing factor 19	PLRG1;BCAS2;WRN;CDC5L;PRPF19	None;DAM1;RECQ3 RECQL2;KIAA0432 PCDC5RP;NMP200 PRP19 SNEV
7938	CDC5L-PRP19 complex	Human	Prp19-CDC5L complex	HeLa cell	O43660;O75934;P11142;Q8WYA6;Q99459;Q9P013;Q9UMS4	5356;10286;3312;56259;988;51503;27339	MI:0091-chromatography technology	GO:0005634;GO:0000398	nucleus;mRNA splicing, via spliceosome	70.10;11.04.03	nucleus;mRNA processing (splicing, 5'-, 3'-end processing)	20176811	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Pleiotropic regulator 1;Pre-mRNA-splicing factor SPF27;Heat shock cognate 71 kDa protein;Beta-catenin-like protein 1;Cell division cycle 5-like protein;Spliceosome-associated protein CWC15 homolog;Pre-mRNA-processing factor 19	PLRG1;BCAS2;HSPA8;CTNNBL1;CDC5L;CWC15;PRPF19	None;DAM1;HSC70 HSP73 HSPA10;C20orf33;KIAA0432 PCDC5RP;C11orf5;NMP200 PRP19 SNEV
7939	CDC5L-PRP19 core complex	Human	None	HeLa cell	O43660;O75934;Q99459;Q9UMS4	5356;10286;988;27339	MI:0004-affinity chromatography technology	GO:0005634;GO:0000398	nucleus;mRNA splicing, via spliceosome	70.10;11.04.03	nucleus;mRNA processing (splicing, 5'-, 3'-end processing)	20176811	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Pleiotropic regulator 1;Pre-mRNA-splicing factor SPF27;Cell division cycle 5-like protein;Pre-mRNA-processing factor 19	PLRG1;BCAS2;CDC5L;PRPF19	None;DAM1;KIAA0432 PCDC5RP;NMP200 PRP19 SNEV
7940	INSIG2-RNF139 complex	Human	None	TRC8-HA-FlPln cells (HEK293)	Q8WU17;Q9Y5U4	11236;51141	MI:0007-anti tag coimmunoprecipitation	GO:0055088;GO:0017148;GO:0016567	lipid homeostasis;negative regulation of translation;protein ubiquitination	14.07.05	modification by ubiquitination, deubiquitination	20068067	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase RNF139;Insulin-induced gene 2 protein	RNF139;INSIG2	TRC8;None
7942	EXPH5-HDAC6-TM4SF5 complex	Human	TM4SF5-HDAC6-Exophilin-5 complex; HDAC6-SLAC2B-TM4SF5 complex	SNU449 cell line	O14894;Q8NEV8;Q9UBN7	9032;23086;10013	MI:0019-coimmunoprecipitation	GO:0016192;GO:0031256;GO:0016477	vesicle-mediated transport;leading edge membrane;cell migration	20.09.07;34.05.01	vesicular transport (Golgi network, etc.);cell migration	33554392	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transmembrane 4 L6 family member 5;Exophilin-5;Histone deacetylase 6	TM4SF5;EXPH5;HDAC6	None;KIAA0624 SLAC2B;KIAA0901
7943	TM4SF5-ITGA5-EGFR complex	Human	None	SNU761 live cells	O14894;P00533;P08648	9032;1956;3678	MI:0019-coimmunoprecipitation;MI:0052-fluorescence correlation spectroscopy	GO:0005886;GO:0016477	plasma membrane;cell migration	70.02;34.05.01	eukaryotic plasma membrane / membrane attached;cell migration	28073834	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transmembrane 4 L6 family member 5;Epidermal growth factor receptor;Integrin alpha-5	TM4SF5;EGFR;ITGA5	None;ERBB ERBB1 HER1;FNRA
7944	TM4SF5-mTOR-SLC38A9 complex	Human	None	HEK293FT cell	O14894;P42345;Q8NBW4	9032;2475;153129	MI:0019-coimmunoprecipitation	GO:0031929;GO:0005765	TOR signaling;lysosomal membrane	None	None	30956113	Upon arginine depletion, TM4SF5 localizes mostly to the plasma membrane but upon arginine sufficiency, TM4SF5 translocated to LAMP-positive lysosomes to bind mTOR and SLC38A9. This indicates, that TM4SF5 functions as arginine sensor. TM4SF5 directly binds free L-arginine via its extracellular loop possibly for the efflux.(PMID:30956113)	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transmembrane 4 L6 family member 5;Serine/threonine-protein kinase mTOR;Sodium-coupled neutral amino acid transporter 9	TM4SF5;MTOR;SLC38A9	None;FRAP FRAP1 FRAP2 RAFT1 RAPT1;URLC11
7945	ITGA3-ITGB1-CD151 complex	Human	alpha(3)-beta (1)-CD151 complex	MDA MB 231 cell	P05556;P26006;P48509	3688;3675;977	MI:0055-fluorescent resonance energy transfer	GO:0016477;GO:0007160	cell migration;cell-matrix adhesion	34.05.01;34.07.02	cell migration;cell-matrix adhesion	22986527	The association between integrin alpha-3-beta1 and CD151 occurs dynamically within discrete subcellular compartments and acts to establish local GTPase signalling to promote tumour cell invasion. (PMID: 22986527)	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-1;Integrin alpha-3;CD151 antigen	ITGB1;ITGA3;CD151	FNRB, MDF2, MSK12;MSK18;TSPAN24
7946	SIX3-LSD1-NuRD(MTA3) Complex	Human	None	HeLa, MCF-7, and MDA-MB-231 cells	O60341;O95343;O95983;Q09028;Q13547;Q16576;Q92769;Q9BTC8;Q9UBB5	23028;6496;53615;5928;3065;5931;3066;57504;8932	MI:0019-coimmunoprecipitation;MI:0091-chromatography technology;MI:0096-pull down	GO:0001837;GO:0005634;GO:0010468;GO:0006355;GO:0007224;GO:0016055	epithelial to mesenchymal transition;nucleus;regulation of gene expression;regulation of DNA-templated transcription;smoothened signaling pathway;Wnt signaling pathway	70.10;11.02.03.04;30.05.02.16;30.05.02.20	nucleus;transcriptional control;hedgehog-dependent signalling pathway;Wnt signalling pathway	29463994	None	The SIX3-LSD1-NuRD(MTA3) complex inhibits carcinogenesis in breast cancer cells and suppresses metastasis in breast cancer. High SIX3 expression is correlated with improved prognosis. (PMID: 29463994)	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Lysine-specific histone demethylase 1A;Homeobox protein SIX3;Methyl-CpG-binding domain protein 3;Histone-binding protein RBBP4;Histone deacetylase 1;Histone-binding protein RBBP7;Histone deacetylase 2;Metastasis-associated protein MTA3;Methyl-CpG-binding domain protein 2	KDM1A;SIX3;MBD3;RBBP4;HDAC1;RBBP7;HDAC2;MTA3;MBD2	AOF2 KDM1 KIAA0601 LSD1;None;None;RBAP48;RPD3L1;RBAP46;None;KIAA1266;None
7947	MBD3-NuRD complex	Human	None	HeLa cell line	O14519;O94776;O95983;Q09028;Q12873;Q13547;Q14839;Q16576;Q86UK7;Q86YP4;Q8WXI9;Q92769;Q9ULU4	8099;9219;53615;5928;1107;3065;1108;5931;90850;54815;57459;3066;23613	MI:0004-affinity chromatography technology;MI:0096-pull down	None	None	None	None	23066101	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cyclin-dependent kinase 2-associated protein 1;Metastasis-associated protein MTA2;Methyl-CpG-binding domain protein 3;Histone-binding protein RBBP4;Chromodomain-helicase-DNA-binding protein 3;Histone deacetylase 1;Chromodomain-helicase-DNA-binding protein 4;Histone-binding protein RBBP7;E3 ubiquitin-protein ligase ZNF598;Transcriptional repressor p66-alpha;Transcriptional repressor p66-beta;Histone deacetylase 2;Protein kinase C-binding protein 1	CDK2AP1;MTA2;MBD3;RBBP4;CHD3;HDAC1;CHD4;RBBP7;ZNF598;GATAD2A;GATAD2B;HDAC2;ZMYND8	CDKAP1 DOC1;MTA1L1 PID;None;RBAP48;None;RPD3L1;None;RBAP46;None;None;KIAA1150;None;KIAA1125 PRKCBP1 RACK7
7949	USH1G-USH2A-WHRN complex	Human	SANS-USH2A-whirlin complex	in vitro	O75445;Q495M9;Q9P202	7399;124590;25861	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0007605;GO:0050953;GO:0032391;GO:0007601	sensory perception of sound;sensory perception of light stimulus;photoreceptor connecting cilium;visual perception	36.25.01.03;34.11.01.03	hearing;visual transduction	28137943	None	Mutations in USH1G, USH2A, or WHRN cause Usher syndrome, the most common form of inherited deaf-blindness.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Usherin;pre-mRNA splicing regulator USH1G;Whirlin	USH2A;USH1G;WHRN	None;SANS;DFNB31 KIAA1526
7950	NFKB2(p49)-RELA-SP1 complex	Human	None	reticulocyte lysate	P08047;Q00653-3;Q04206	6667;4791;5970	MI:0409-dna footprinting;MI:0413-electrophoretic mobility shift assay	GO:0010468	regulation of gene expression	None	None	8253080	Results suggest that an interaction between NF-kappa B (p49) and SP1 is required for inducible HIV-1 gene expression and may serve as a regulatory mechanism to activate specific viral and cellular genes.	None	NFKB2(p49) (Q00653-3) is a splice variant of NFKB2.The interaction of NF-kappa B with SP1 is specific and is dependent upon orientation and spacing.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transcription factor Sp1;Isoform 3 of Nuclear factor NF-kappa-B p100 subunit;Transcription factor p65	SP1;NFKB2;RELA	TSFP1;LYT10;NFKB3
7952	IRF8-SPI1-STAT1 complex	Human	None	THP-1 cells	P17947;P42224;Q02556	6688;6772;3394	MI:0402-chromatin immunoprecipitation assay;MI:0413-electrophoretic mobility shift assay	GO:0005634;GO:0010628	nucleus;positive regulation of gene expression	70.10	nucleus	17386941	Phosphorylation of IRF8 in a pre-associated complex with SPI1 (PU.1) and non-phosphorylated STAT1 is critical for lipopolysaccharide induction of the IL1B gene.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transcription factor PU.1;Signal transducer and activator of transcription 1-alpha/beta;Interferon regulatory factor 8	SPI1;STAT1;IRF8	None;None;ICSBP1
7953	IRF1-STAT1 complex	Human	None	U3A cells	P10914;P42224	3659;6772	MI:0096-pull down	GO:0045893	positive regulation of DNA-templated transcription	11.02.03.04.01	transcription activation	10921891	The complex of unphosphorylated STAT1 and IRF1 supports transcription of the LMP2 gene. In the absence of IFN stimulation, Stat1 binds to the consensus sequence 2/gamma-interferon-activated sequence (ICS-2/GAS) element of the LMP2 gene but not to the IRF1 GAS.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Interferon regulatory factor 1;Signal transducer and activator of transcription 1-alpha/beta	IRF1;STAT1	None;None
7954	BIF1-UVRAG-Beclin1 complex	Human	SH3GLB1-UVRAG-BECN1 complex; BECN1-SH3GLB1-UVRAG complex	HEK293T cell; HeLa cell	Q14457;Q9P2Y5;Q9Y371	8678;7405;51100	MI:0019-coimmunoprecipitation	GO:0006914;GO:0000045;GO:0042594	autophagy;autophagosome assembly;response to starvation	32.01.11	nutrient starvation response	17891140	Bif-1 forms a complex with Beclin1 through ultraviolet irradiation resistance-associated gene (UVRAG) to facilitate the activation of the PI3KC3 lipid kinase and autophagosome formation under starvation conditions (PMID: 17891140).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Beclin-1;UV radiation resistance-associated gene protein;Endophilin-B1	BECN1;UVRAG;SH3GLB1	GT197;None;KIAA0491
7955	CREBBP-EP300-HDAC1-SP1-SP3 complex	Human	None	SAOS-2 cells	P08047;Q02447;Q09472;Q13547;Q92793	6667;6670;2033;3065;1387	MI:0019-coimmunoprecipitation	GO:0006351	DNA-templated transcription	11	TRANSCRIPTION	16734381	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transcription factor Sp1;Transcription factor Sp3;Histone acetyltransferase p300;Histone deacetylase 1;CREB-binding protein	SP1;SP3;EP300;HDAC1;CREBBP	TSFP1;None;P300;RPD3L1;CBP
7956	NRIP1-YWHAH complex	Human	None	in vitro; COS-7 cells	P48552;Q04917	8204;7533	MI:0007-anti tag coimmunoprecipitation	GO:0045893;GO:0005634;GO:0005737	positive regulation of DNA-templated transcription;nucleus;cytoplasm	11.02.03.04.01;70.10;70.03	transcription activation;nucleus;cytoplasm	11266503	The 14\u20133-3 protein YWHAH can interact with the nuclear receptor corepressor RIP140 and change its subcellular localization. It is suggested that the positive effect of 14\u20133-3 on GR transactivation is due to 14\u20133-3 binding to RIP140 and removing the negatively acting RIP140 from the nucleus, allowing positively acting coactivator proteins to interact with the receptor.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Nuclear receptor-interacting protein 1;14-3-3 protein eta	NRIP1;YWHAH	None;YWHA1
7957	CASP8-CASP10-FADD-FLIP(S)-RIPK1 complex	Human	Ripoptosome	HaCaT cells	O15519-2;Q13158;Q13546;Q14790;Q92851	8837;8772;8737;841;843	MI:0071-molecular sieving	GO:0006915	apoptotic process	40.10.02	apoptosis (type I programmed cell death)	21737330	Loss of cIAPs promotes the spontaneous formation of an intracellular platform that activates either apoptosis or necroptosis. This 2 MDa intracellular complex that was designated \u2018\u2018Ripoptosome\u2019\u2019 is necessary but not sufficient for cell death. When cIAPs are absent, caspase activity is the \u2018\u2018rheostat\u2019\u2019 that is controlled by cFLIP isoforms in the Ripoptosome and decides if cell death occurs by RIP3-dependent necroptosis or caspase-dependent apoptosis.	None	FLIP-S (O15519-2) is a splice variant of CFLAR.cFLIP(L) prevents Ripoptosome formation, whereas, intriguingly, cFLIP(S) promotes Ripoptosome assembly.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Isoform 2 of CASP8 and FADD-like apoptosis regulator;FAS-associated death domain protein;Receptor-interacting serine/threonine-protein kinase 1;Caspase-8;Caspase-10	CFLAR;FADD;RIPK1;CASP8;CASP10	CASH CASP8AP1 CLARP MRIT;MORT1;RIP, RIP1;MCH5;MCH4
7958	Pyrin inflammasome	Human	MEFV inflammasome; CASP1-MEFV-PYCARD complex; ASC-Procaspase1-Pyrin complex	HEK293 cell extracts	O15553;P29466;Q9ULZ3	4210;834;29108	MI:0007-anti tag coimmunoprecipitation	GO:0045087;GO:0002221;GO:0032731;GO:0061702;GO:0050729;GO:0042742;GO:0140447	innate immune response;pattern recognition receptor signaling pathway;positive regulation of interleukin-1 beta production;inflammasome complex;positive regulation of inflammatory response;defense response to bacterium;cytokine precursor processing	36.25.16.01	innate immune response (invertebrates and vertebrates)	16037825	MEFV (Pyrin), like cryopyrin (NLRP3), can assemble an inflammasome complex with ASC and procaspase-1 leading to ASC oligomerization, caspase-1 activation and interleukin-1beta processing.	Mutations in cryopyrin and pyrin (MEFV) proteins are responsible for several autoinflammatory disorders in humans. (PMID:16037825; 31456795)	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Pyrin;Caspase-1;Apoptosis-associated speck-like protein containing a CARD	MEFV;CASP1;PYCARD	MEF,TRIM20;IL1BC, IL1BCE;ASC CARD5 TMS1
7960	ER membrane protein complex (EMC8)	Human	None	in vitro	O43402;Q15006;Q5J8M3;Q5UCC4;Q8N4V1;Q8N766;Q9BV81;Q9NPA0;Q9P0I2	10328;9694;51234;284361;93380;23065;83460;56851;55831	MI:0040-electron microscopy	GO:0045048	protein insertion into ER membrane	None	None	32439656	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	ER membrane protein complex subunit 8;ER membrane protein complex subunit 2;ER membrane protein complex subunit 4;ER membrane protein complex subunit 10;ER membrane protein complex subunit 5;ER membrane protein complex subunit 1;ER membrane protein complex subunit 6;ER membrane protein complex subunit 7;ER membrane protein complex subunit 3	EMC8;EMC2;EMC4;EMC10;MMGT1;EMC1;EMC6;EMC7;EMC3	C16orf2 C16orf4 COX4AL COX4NB FAM158B NOC4;KIAA0103,TTC35;TMEM85;C19orf63 INM02;EMC5,TMEM32;KIAA0090;TMEM93;C11orf3 C15orf24;TMEM111
7961	ER membrane protein complex (EMC9)	Human	None	in vitro	Q15006;Q5J8M3;Q5UCC4;Q8N4V1;Q8N766;Q9BV81;Q9NPA0;Q9P0I2;Q9Y3B6	9694;51234;284361;93380;23065;83460;56851;55831;51016	MI:0040-electron microscopy	GO:0045048	protein insertion into ER membrane	None	None	32439656	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	ER membrane protein complex subunit 2;ER membrane protein complex subunit 4;ER membrane protein complex subunit 10;ER membrane protein complex subunit 5;ER membrane protein complex subunit 1;ER membrane protein complex subunit 6;ER membrane protein complex subunit 7;ER membrane protein complex subunit 3;ER membrane protein complex subunit 9	EMC2;EMC4;EMC10;MMGT1;EMC1;EMC6;EMC7;EMC3;EMC9	KIAA0103,TTC35;TMEM85;C19orf63 INM02;EMC5,TMEM32;KIAA0090;TMEM93;C11orf3 C15orf24;TMEM111;C14orf122,FAM158A
7962	SMC5-6-NSMCE4A complex	Human	NSMCE1-NSMCE2-NSMCE3-NSMCE4A-SMC5-SMC6 complex	HeLa nuclear extract	Q8IY18;Q8WV22;Q96MF7;Q96MG7;Q96SB8;Q9NXX6	23137;197370;286053;56160;79677;54780	MI:0019-coimmunoprecipitation;MI:0071-molecular sieving	GO:0005634;GO:0006281	nucleus;DNA repair	70.10;10.01.05.01	nucleus;DNA repair	18086888	The complex has approx. 800 kDa.	None	The protein complex includes either NSMCE4A or EID3.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Structural maintenance of chromosomes protein 5;Non-structural maintenance of chromosomes element 1 homolog;E3 SUMO-protein ligase NSE2;Non-structural maintenance of chromosomes element 3 homolog;Structural maintenance of chromosomes protein 6;Non-structural maintenance of chromosomes element 4 homolog A	SMC5;NSMCE1;NSMCE2;NSMCE3;SMC6;NSMCE4A	KIAA0594 SMC5L1;None;C8orf36 MMS21;HCA4 MAGEG1 NDNL2;SMC6L1;C10orf86
7963	SMC5-6-EID3 complex	Human	NSMCE1-NSMCE2-NSMCE3-EID3-SMC5-SMC6 complex	HeLa nuclear extract.	Q8IY18;Q8N140;Q8WV22;Q96MF7;Q96MG7;Q96SB8	23137;493861;197370;286053;56160;79677	MI:0019-coimmunoprecipitation;MI:0071-molecular sieving	GO:0005634;GO:0006281	nucleus;DNA repair	70.10;10.01.05.01	nucleus;DNA repair	18086888	The complex has approx. 800 kDa.	None	The protein complex includes either NSMCE4A or EID3.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Structural maintenance of chromosomes protein 5;EP300-interacting inhibitor of differentiation 3;Non-structural maintenance of chromosomes element 1 homolog;E3 SUMO-protein ligase NSE2;Non-structural maintenance of chromosomes element 3 homolog;Structural maintenance of chromosomes protein 6	SMC5;EID3;NSMCE1;NSMCE2;NSMCE3;SMC6	KIAA0594 SMC5L1;None;None;C8orf36 MMS21;HCA4 MAGEG1 NDNL2;SMC6L1
7964	NUBP1-NUBP2 complex	Human	None	HeLa cells	P53384;Q9Y5Y2	4682;10101	MI:0007-anti tag coimmunoprecipitation	GO:0005829;GO:0055072;GO:0016049	cytosol;iron ion homeostasis;cell growth	40.01	cell growth / morphogenesis	18573874	Results suggest an essential function of the NUBP1-NUBP2 complex for cell growth, for the maturation of cytosolic but not mitochondrial Fe/S proteins, and for cellular iron regulation.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cytosolic Fe-S cluster assembly factor NUBP1;Cytosolic Fe-S cluster assembly factor NUBP2	NUBP1;NUBP2	NBP,NBP1;None
7965	DCTN1-DYNC1I1-NUDC-PLK1 complex	Human	p150 dynactin-CDIC (74 kDa)-NUDC-PLK1 complex	HeLa cells	O14576;P53350;Q14203;Q9Y266	None;5347;1639;10726	MI:0019-coimmunoprecipitation	GO:0000910	cytokinesis	10.03.03	cytokinesis (cell division) /septum formation and hydrolysis	12852857	PLK1 phosphorylation of NUDC may influence cytokinesis.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cytoplasmic dynein 1 intermediate chain 1;Serine/threonine-protein kinase PLK1;Dynactin subunit 1;Nuclear migration protein nudC	DYNC1I1;PLK1;DCTN1;NUDC	DNCI1 DNCIC1;PLK;None;None
7966	ALYREF-NXF1-RBM8A-UPF3A complex	Human	ALYREF-TAP-Y14-UPF3A complex	293T cells	Q86V81;Q9H1J1;Q9UBU9;Q9Y5S9	10189;65110;10482;9939	MI:0019-coimmunoprecipitation	GO:0005654;GO:0000184;GO:0051168	nucleoplasm;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;nuclear export	None	None	11546873	Experiments suggest that hUpf3 is a bona fide component of the nuclear mRNP complex that is produced by splicing, and that hUpf3 binds specifically upstream of exon-exon junctions. Moreover, hUpf3 interacts with Y14 via protein-protein interaction and thus participates with Y14 in the formation of the complex that assembles approx. 20 nt relative to exon-exon junctions. This splicing-dependent exon-exon junction complex appears to be multifunctional.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	THO complex subunit 4;Regulator of nonsense transcripts 3A;Nuclear RNA export factor 1;RNA-binding protein 8A	ALYREF;UPF3A;NXF1;RBM8A	ALY BEF THOC4;RENT3A UPF3;TAP;RBM8
7967	ALYREF-NXF1-RBM8A-UPF3B complex	Human	ALYREF-TAP-Y14-UPF3B complex	293T cells	Q86V81;Q9BZI7;Q9UBU9;Q9Y5S9	10189;65109;10482;9939	MI:0019-coimmunoprecipitation	GO:0005654;GO:0000184;GO:0051168	nucleoplasm;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;nuclear export	None	None	11546873	Experiments suggest that hUpf3 is a bona fide component of the nuclear mRNP complex that is produced by splicing, and that hUpf3 binds specifically upstream of exon-exon junctions. Moreover, hUpf3 interacts with Y14 via protein-protein interaction and thus participates with Y14 in the formation of the complex that assembles approx. 20 nt relative to exon-exon junctions. This splicing-dependent exon-exon junction complex appears to be multifunctional.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	THO complex subunit 4;Regulator of nonsense transcripts 3B;Nuclear RNA export factor 1;RNA-binding protein 8A	ALYREF;UPF3B;NXF1;RBM8A	ALY BEF THOC4;RENT3B, UPF3X;TAP;RBM8
7968	NXF1-NXT1 complex	Human	TAP/p15 complex	HeLa cells	Q9UBU9;Q9UKK6	10482;29107	MI:0019-coimmunoprecipitation;MI:0226-ion exchange chromatography	GO:0006405;GO:0005634	RNA export from nucleus;nucleus	70.10	nucleus	10228171	TAP-p15 heterodimers have been implicated in the export of mRNAs through nuclear pore complexes.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Nuclear RNA export factor 1;NTF2-related export protein 1	NXF1;NXT1	TAP;None
7969	OTUB1-RNF128-USP8 complex	Human	OTUB1-GRAIL-USP8 complex	HEK293 cells	P40818;Q8TEB7;Q96FW1-1	9101;79589;55611	MI:0019-coimmunoprecipitation	GO:0002667	regulation of T cell anergy	None	None	14661020	Separate splice variants of the same gene, called otubain 1, serve as epistatic regulators to destabilize (otubain 1) or stabilize (otubain 1 ARF-1) autoubiquitinated GRAIL and thus control the outcome of T cell signaling and anergy induction.	None	Otubain-1 (Q96FW1-1) is a long splice variant of OTUB1 and interacts with USP8. The short splice variant ARF-1 (Q96FW1-2) of OTUB1 does not interact with USP8 and not a member of OTUB1-RNF128-USP8 complex (PMID:14661020).	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Ubiquitin carboxyl-terminal hydrolase 8;E3 ubiquitin-protein ligase RNF128;Isoform 1 of Ubiquitin thioesterase OTUB1	USP8;RNF128;OTUB1	KIAA0055 UBPY;None;OTB1 OTU1
7971	GIT1-MAT2B complex	Human	None	HepG2 cells; RKO cells; NCM460 cells	Q9NZL9;Q9Y2X7	27430;28964	MI:0019-coimmunoprecipitation;MI:0416-fluorescence microscopy	GO:0007265;GO:0000165	Ras protein signal transduction;MAPK cascade	30.01.05.01.03	MAPKKK cascade	25794709	MAT2B-GIT1 is a scaffold complex that regulates multiple steps in the Ras-Raf-MEK-ERK signaling cascade.	The relevance of MAT2B-GIT1 interaction was confirmed in human HCC and colon cancer specimens.	None	Homo sapiens (Human);Homo sapiens (Human)	Methionine adenosyltransferase 2 subunit beta;ARF GTPase-activating protein GIT1	MAT2B;GIT1	TGR;None
7974	cBAF complex	Human	canonical BAF complex	HEK-293 cells	O14497;O96019;P51532;P60709;Q12824;Q4VC05;Q8NFD5;Q8TAQ2;Q8WUZ0;Q92785;Q92922;Q92925;Q969G3;Q96GM5	8289;86;6597;60;6598;605;57492;6601;9274;5977;6599;6603;6605;6602	MI:0007-anti tag coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0006338;GO:0070603;GO:0006355	chromatin remodeling;SWI/SNF superfamily-type complex;regulation of DNA-templated transcription	11.02.03.04	transcriptional control	1234567	The megadalton-sized mammalian SWI/SNF (mSWI/SNF, or BAF) family of adenosine triphosphate (ATP)\u2013dependent chromatin remodeling complexes contains multiple histone recognition domains (readers) and generally sequence-non-specific DNA binding domains and thus has the potential for combinatorial readout of diverse epigenetic modifications and nucleosomal features. The cBAF complex has a mass of 1.04 MDa.	None	All BAF complexes contain an ATPase subunit, either SMARCA4 (BRG1) or SMARCA2 (BRM), that catalyzes the hydrolysis of ATP. In this entry, we used SMARCA4.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	AT-rich interactive domain-containing protein 1A;Actin-like protein 6A;Transcription activator BRG1;Actin, cytoplasmic 1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1;B-cell CLL/lymphoma 7 protein family member A;AT-rich interactive domain-containing protein 1B;SWI/SNF complex subunit SMARCC2;B-cell CLL/lymphoma 7 protein family member C;Zinc finger protein ubi-d4;SWI/SNF complex subunit SMARCC1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1	ARID1A;ACTL6A;SMARCA4;ACTB;SMARCB1;BCL7A;ARID1B;SMARCC2;BCL7C;DPF2;SMARCC1;SMARCD2;SMARCE1;SMARCD1	BAF250 BAF250A C1orf4 OSA1 SMARCF1;BAF53 BAF53A INO80K;BAF190A BRG1 SNF2B SNF2L4;None;BAF47, INI1, SNF5L1;None;BAF250B DAN15 KIAA1235 OSA2;BAF170;None;BAF45D REQ UBID4;BAF155;BAF60B;BAF57;BAF60A
7975	PBAF complex	Human	polybromo-associated BAF complex	HEK293 cells	O96019;P51532;P60709;Q12824;Q4VC05;Q68CP9;Q86U86;Q8TAQ2;Q8WUB8;Q8WUZ0;Q92922;Q969G3;Q96GM5;Q9NPI1	86;6597;60;6598;605;196528;55193;6601;55274;9274;6599;6605;6602;29117	MI:0007-anti tag coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0006338;GO:0006355;GO:0071565	chromatin remodeling;regulation of DNA-templated transcription;nBAF complex	11.02.03.04	transcriptional control	1234567	The megadalton-sized mammalian SWI/SNF (mSWI/SNF, or BAF) family of adenosine triphosphate (ATP)\u2013dependent chromatin remodeling complexes contains multiple histone recognition domains (readers) and generally sequence-non-specific DNA binding domains and thus has the potential for combinatorial readout of diverse epigenetic modifications and nucleosomal features. The PBAF complex has a mass of 1.41 MDa.	None	All BAF complexes contain an ATPase subunit, either SMARCA4 (BRG1) or SMARCA2 (BRM), that catalyzes the hydrolysis of ATP. In this entry, we used SMARCA4.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Actin-like protein 6A;Transcription activator BRG1;Actin, cytoplasmic 1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1;B-cell CLL/lymphoma 7 protein family member A;AT-rich interactive domain-containing protein 2;Protein polybromo-1;SWI/SNF complex subunit SMARCC2;PHD finger protein 10;B-cell CLL/lymphoma 7 protein family member C;SWI/SNF complex subunit SMARCC1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1;Bromodomain-containing protein 7	ACTL6A;SMARCA4;ACTB;SMARCB1;BCL7A;ARID2;PBRM1;SMARCC2;PHF10;BCL7C;SMARCC1;SMARCE1;SMARCD1;BRD7	BAF53 BAF53A INO80K;BAF190A BRG1 SNF2B SNF2L4;None;BAF47, INI1, SNF5L1;None;BAF200 KIAA1557;BAF180 PB1;BAF170;BAF45A;None;BAF155;BAF57;BAF60A;BP75 CELTIX1
7976	SIX3-LSD1-MTA3 complex	Human	None	MCF-7 cell	O60341;O95343;Q9BTC8	23028;6496;57504	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0001837;GO:0005634;GO:0010468;GO:0016055;GO:0007224;GO:0006355	epithelial to mesenchymal transition;nucleus;regulation of gene expression;Wnt signaling pathway;smoothened signaling pathway;regulation of DNA-templated transcription	70.10;30.05.02.20;30.05.02.16;11.02.03.04	nucleus;Wnt signalling pathway;hedgehog-dependent signalling pathway;transcriptional control	29463994	The transcriptional regulators SIX3, LSD1, and MTA3 cooperate to operate a transcriptional repression pathway that maintains mammary epithelial hemostasis by controlling the hierarchical molecular network of epithelial-to-mesenchymal transition. (PMID: 29463994)	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Lysine-specific histone demethylase 1A;Homeobox protein SIX3;Metastasis-associated protein MTA3	KDM1A;SIX3;MTA3	AOF2 KDM1 KIAA0601 LSD1;None;KIAA1266
7977	cBAF complex	Human	canonical BAF complex	HEK293 cells	O14497;O96019;P51531;P60709;Q12824;Q4VC05;Q8NFD5;Q8TAQ2;Q8WUZ0;Q92785;Q92922;Q92925;Q969G3;Q96GM5	8289;86;6595;60;6598;605;57492;6601;9274;5977;6599;6603;6605;6602	MI:0019-coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0006338;GO:0071565;GO:0006355	chromatin remodeling;nBAF complex;regulation of DNA-templated transcription	11.02.03.04	transcriptional control	1234567	The megadalton-sized mammalian SWI/SNF (mSWI/SNF, or BAF) family of adenosine triphosphate (ATP)\u2013dependent chromatin remodeling complexes contains multiple histone recognition domains (readers) and generally sequence-non-specific DNA binding domains and thus has the potential for combinatorial readout of diverse epigenetic modifications and nucleosomal features. The cBAF complex has a mass of 1.04 MDa.	None	All BAF complexes contain an ATPase subunit, either SMARCA4 (BRG1) or SMARCA2 (BRM), that catalyzes the hydrolysis of ATP. In this entry, we used SMARCA2.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	AT-rich interactive domain-containing protein 1A;Actin-like protein 6A;Probable global transcription activator SNF2L2;Actin, cytoplasmic 1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1;B-cell CLL/lymphoma 7 protein family member A;AT-rich interactive domain-containing protein 1B;SWI/SNF complex subunit SMARCC2;B-cell CLL/lymphoma 7 protein family member C;Zinc finger protein ubi-d4;SWI/SNF complex subunit SMARCC1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1	ARID1A;ACTL6A;SMARCA2;ACTB;SMARCB1;BCL7A;ARID1B;SMARCC2;BCL7C;DPF2;SMARCC1;SMARCD2;SMARCE1;SMARCD1	BAF250 BAF250A C1orf4 OSA1 SMARCF1;BAF53 BAF53A INO80K;BAF190B BRM SNF2A SNF2L2;None;BAF47, INI1, SNF5L1;None;BAF250B DAN15 KIAA1235 OSA2;BAF170;None;BAF45D REQ UBID4;BAF155;BAF60B;BAF57;BAF60A
7978	PBAF complex	Human	polybromo-associated BAF complex	HEK293 cells	O96019;P51531;P60709;Q12824;Q4VC05;Q68CP9;Q86U86;Q8TAQ2;Q8WUB8;Q8WUZ0;Q92922;Q969G3;Q96GM5;Q9NPI1	86;6595;60;6598;605;196528;55193;6601;55274;9274;6599;6605;6602;29117	MI:0019-coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0006338;GO:0071565;GO:0006355	chromatin remodeling;nBAF complex;regulation of DNA-templated transcription	11.02.03.04	transcriptional control	1234567	The megadalton-sized mammalian SWI/SNF (mSWI/SNF, or BAF) family of adenosine triphosphate (ATP)\u2013dependent chromatin remodeling complexes contains multiple histone recognition domains (readers) and generally sequence-non-specific DNA binding domains and thus has the potential for combinatorial readout of diverse epigenetic modifications and nucleosomal features. The PBAF complex has a mass of 1.41 MDa.	None	All BAF complexes contain an ATPase subunit, either SMARCA4 (BRG1) or SMARCA2 (BRM), that catalyzes the hydrolysis of ATP. In this entry, we used SMARCA2.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Actin-like protein 6A;Probable global transcription activator SNF2L2;Actin, cytoplasmic 1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1;B-cell CLL/lymphoma 7 protein family member A;AT-rich interactive domain-containing protein 2;Protein polybromo-1;SWI/SNF complex subunit SMARCC2;PHD finger protein 10;B-cell CLL/lymphoma 7 protein family member C;SWI/SNF complex subunit SMARCC1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1;Bromodomain-containing protein 7	ACTL6A;SMARCA2;ACTB;SMARCB1;BCL7A;ARID2;PBRM1;SMARCC2;PHF10;BCL7C;SMARCC1;SMARCE1;SMARCD1;BRD7	BAF53 BAF53A INO80K;BAF190B BRM SNF2A SNF2L2;None;BAF47, INI1, SNF5L1;None;BAF200 KIAA1557;BAF180 PB1;BAF170;BAF45A;None;BAF155;BAF57;BAF60A;BP75 CELTIX1
7979	WDTC1-DDB1-CUL4-ROC1 E3 ligase complex	Human	WDTC1-DDB1-CRL4 E3 ligase complex; CRL4(WDTC) complex	HEK293T cells	P62877;Q13619;Q13620;Q16531;Q8N5D0	9978;8451;8450;1642;23038	MI:0004-affinity chromatography technology	GO:0060612;GO:0033522;GO:0010468	adipose tissue development;histone H2A ubiquitination;regulation of gene expression	None	None	27113764	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase RBX1;Cullin-4A;Cullin-4B;DNA damage-binding protein 1;WD and tetratricopeptide repeats protein 1	RBX1;CUL4A;CUL4B;DDB1;WDTC1	RNF75 ROC1;None;KIAA0695;XAP1;KIAA1037
7980	ncBAF complex	Human	non-canonical BAF complex	HEK293 cells	O96019;P51531;P60709;Q15532;Q4VC05;Q6AI39;Q8WUZ0;Q92922;Q96GM5;Q9H8M2	86;6595;60;6760;605;23506;9274;6599;6602;65980	MI:0019-coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0006338;GO:0071565;GO:0006355	chromatin remodeling;nBAF complex;regulation of DNA-templated transcription	11.02.03.04	transcriptional control	1234567	The megadalton-sized mammalian SWI/SNF (mSWI/SNF, or BAF) family of adenosine triphosphate (ATP)\u2013dependent chromatin remodeling complexes contains multiple histone recognition domains (readers) and generally sequence-non-specific DNA binding domains and thus has the potential for combinatorial readout of diverse epigenetic modifications and nucleosomal features.\u00a0The ncBAF complex has a mass of 0.87 MDa.	None	All BAF complexes contain an ATPase subunit, either SMARCA4 (BRG1) or SMARCA2 (BRM), that catalyzes the hydrolysis of ATP. In this entry, we used SMARCA2.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Actin-like protein 6A;Probable global transcription activator SNF2L2;Actin, cytoplasmic 1;Protein SSXT;B-cell CLL/lymphoma 7 protein family member A;BRD4-interacting chromatin-remodeling complex-associated protein-like;B-cell CLL/lymphoma 7 protein family member C;SWI/SNF complex subunit SMARCC1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1;Bromodomain-containing protein 9	ACTL6A;SMARCA2;ACTB;SS18;BCL7A;BICRAL;BCL7C;SMARCC1;SMARCD1;BRD9	BAF53 BAF53A INO80K;BAF190B BRM SNF2A SNF2L2;None;SSXT SYT;None;GLTSCR1L KIAA0240;None;BAF155;BAF60A;None
7981	ncBAF complex	Human	non-canonical BAF complex	HEK293 cells	O96019;P51532;P60709;Q15532;Q4VC05;Q6AI39;Q8WUZ0;Q92922;Q96GM5;Q9H8M2	86;6597;60;6760;605;23506;9274;6599;6602;65980	MI:0019-coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0006338;GO:0071565;GO:0006355	chromatin remodeling;nBAF complex;regulation of DNA-templated transcription	11.02.03.04	transcriptional control	1234567	The megadalton-sized mammalian SWI/SNF (mSWI/SNF, or BAF) family of adenosine triphosphate (ATP)\u2013dependent chromatin remodeling complexes contains multiple histone recognition domains (readers) and generally sequence-non-specific DNA binding domains and thus has the potential for combinatorial readout of diverse epigenetic modifications and nucleosomal features.\u00a0The PBAF complex has a mass of 0.87 MDa.	None	All BAF complexes contain an ATPase subunit, either SMARCA4 (BRG1) or SMARCA2 (BRM), that catalyzes the hydrolysis of ATP. In this entry, we used SMARCA4.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Actin-like protein 6A;Transcription activator BRG1;Actin, cytoplasmic 1;Protein SSXT;B-cell CLL/lymphoma 7 protein family member A;BRD4-interacting chromatin-remodeling complex-associated protein-like;B-cell CLL/lymphoma 7 protein family member C;SWI/SNF complex subunit SMARCC1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1;Bromodomain-containing protein 9	ACTL6A;SMARCA4;ACTB;SS18;BCL7A;BICRAL;BCL7C;SMARCC1;SMARCD1;BRD9	BAF53 BAF53A INO80K;BAF190A BRG1 SNF2B SNF2L4;None;SSXT SYT;None;GLTSCR1L KIAA0240;None;BAF155;BAF60A;None
7984	Kallikrein 6-(alpha)1-antichymotrypsin complex	Human	KLK6-SERPINA3 complex	breast milk and ascites fluid from ovarian cancer patients	P01011;Q92876	12;5653	MI:0004-affinity chromatography technology;MI:0071-molecular sieving	None	None	None	None	12709365	None	Human kallikrein 6 is partially complexed with alpha(1)-antichymotrypsin in milk and ascites fluid of ovarian cancer patients.	None	Homo sapiens (Human);Homo sapiens (Human)	Alpha-1-antichymotrypsin;Kallikrein-6	SERPINA3;KLK6	AACT;PRSS18 PRSS9
7985	Prostate-specific antigen-(alpha)1-antichymotrypsin complex	Human	KLK3-SERPINA1 complex	prostate carcinoma serum	P01009;P07288	5265;354	MI:0071-molecular sieving	GO:0071228	cellular response to tumor cell	None	None	1703033	None	A complex between prostate-specific antigen (PSA) and the protease inhibitor alpha 1-antichymotrypsin was observed in serum of patients with prostatic cancer and very high levels of PSA. The proportion of this complex is higher in patients with prostatic cancer than in those with benign prostatic hyperplasia.	None	Homo sapiens (Human);Homo sapiens (Human)	Alpha-1-antitrypsin;Prostate-specific antigen	SERPINA1;KLK3	AAT PI;APS
7986	Glandular kallikrein-(alpha)1-antichymotrypsin complex	Human	hK2-ACT complex; KLK2-SERPINA3 complex	prostate carcinoma serum	P01011;P20151	12;3817	MI:0047-far western blotting	GO:0071228	cellular response to tumor cell	None	None	9733142	None	Glandular kallikrein (hK2) and alpha1-antichymotrypsin form a complex in sera of prostate cancer patients. (PMID: 9733142)	None	Homo sapiens (Human);Homo sapiens (Human)	Alpha-1-antichymotrypsin;Kallikrein-2	SERPINA3;KLK2	AACT;None
7987	FANCI-FANCD2 complex	Human	FANCD2-FANCI complex	Sf9 Cells	Q9BXW9;Q9NVI1	2177;55215	MI:0004-affinity chromatography technology	GO:0006281;GO:0005634	DNA repair;nucleus	10.01.05.01;70.10	DNA repair;nucleus	32092106	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Fanconi anemia group D2 protein;Fanconi anemia group I protein	FANCD2;FANCI	FACD;KIAA1794
7988	FANCG-BRCA2-FANCD2-XRCC3 complex	Human	BRCA2-FANCD2-FANCG-XRCC3 complex	HeLa cells	O15287;O43542;P51587;Q9BXW9	2189;7517;675;2177	MI:0019-coimmunoprecipitation	GO:0005634;GO:0006281;GO:0000725	nucleus;DNA repair;recombinational repair	70.10;10.01.05.01	nucleus;DNA repair	18212739	Phosphorylation of FANCG serine 7 is the signalling event required for forming the complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Fanconi anemia group G protein;DNA repair protein XRCC3;Breast cancer type 2 susceptibility protein;Fanconi anemia group D2 protein	FANCG;XRCC3;BRCA2;FANCD2	XRCC9;None;FACD FANCD1;FACD
7990	NPM1-PA2G4 complex	Human	EBP1-NPM1 complex	HEK293 cells	P06748;Q9UQ80	4869;5036	MI:0007-anti tag coimmunoprecipitation	GO:0042981;GO:0042127	regulation of apoptotic process;regulation of cell population proliferation	None	None	17951246	PA2G4 (Ebp1) forms a complex with NPM1 (B23), and this complex plays a critical role in cell proliferation and survival. p42 specifically associates with B23 upon epidermal growth factor stimulation, while p48 constantly binds B23.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Nucleophosmin;Proliferation-associated protein 2G4	NPM1;PA2G4	NPM;EBP1
7991	PTGDS-TTR complex	Human	PDS-TTR complex	CSF	P02766;P41222	7276;5730	MI:0019-coimmunoprecipitation;MI:0411-enzyme linked immunosorbent assay	None	None	None	None	18448869	None	Double-blind analysis of complexed PDS/TTR in lumbar CSF showed a significant sixfold increase in levels of the PDS/TTR complex in living probable AD (Alzheimer disease) subjects compared with age-matched NC (normal control) subjects and a 100% sensitivity and 93% specificity in the identification of subjects with AD (PMID:18448869).	None	Homo sapiens (Human);Homo sapiens (Human)	Transthyretin;Prostaglandin-H2 D-isomerase	TTR;PTGDS	PALB;PDS
7992	RNA polymerase III complex	Human	DNA-directed RNA polymerase III complex	HeLa cells	O14802;O15160;O15318;O75575;P05423;P0DPB6;P52434;P53803;P62875;Q9BUI4;Q9H1D9;Q9NVU0;Q9NW08;Q9Y2Y1;Q9Y535	11128;9533;10622;27297;661;51082;5437;5440;5441;10623;10621;55718;55703;51728;171568	MI:0040-electron microscopy;MI:0114-x-ray crystallography	GO:0006383;GO:0006386;GO:0006384	transcription by RNA polymerase III;termination of RNA polymerase III transcription;transcription initiation at RNA polymerase III promoter	None	None	33335104	RNA Polymerase (Pol) III is specialized for the transcription of tRNAs and other short, untranslated RNAs. Pol III is a determinant of cellular growth and lifespan across eukaryotes. Upregulation of Pol III transcription is observed in cancer and causative Pol III mutations have been described in neurodevelopmental disorders and hypersensitivity to viral infection. It was reported that a cryo-EM reconstruction at 4.0?\u00c5 of human Pol III, allowing mapping and rationalization of reported genetic mutations. Mutations causing neurodevelopmental defects cluster in hotspots affecting Pol III stability and/or biogenesis, whereas mutations affecting viral sensing are located in proximity to DNA binding regions, suggesting an impairment of Pol III cytosolic viral DNA-sensing.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA-directed RNA polymerase III subunit RPC1;DNA-directed RNA polymerases I and III subunit RPAC1;DNA-directed RNA polymerase III subunit RPC7;DNA-directed RNA polymerase III subunit RPC9;DNA-directed RNA polymerase III subunit RPC4;DNA-directed RNA polymerases I and III subunit RPAC2;DNA-directed RNA polymerases I, II, and III subunit RPABC3;DNA-directed RNA polymerases I, II, and III subunit RPABC4;DNA-directed RNA polymerases I, II, and III subunit RPABC5;DNA-directed RNA polymerase III subunit RPC3;DNA-directed RNA polymerase III subunit RPC6;DNA-directed RNA polymerase III subunit RPC5;DNA-directed RNA polymerase III subunit RPC2;DNA-directed RNA polymerase III subunit RPC10;DNA-directed RNA polymerase III subunit RPC8	POLR3A;POLR1C;POLR3G;CRCP;POLR3D;POLR1D;POLR2H;POLR2K;POLR2L;POLR3C;POLR3F;POLR3E;POLR3B;POLR3K;POLR3H	None;POLR1E;None;None;BN51 BN51T;None;None;None;None;None;None;KIAA1452;None;RPC11;KIAA1665 RPC8
7994	B9D1-B9D2-MKS1 complex	Human	None	HEK293T cells	Q9BPU9;Q9NXB0;Q9UPM9	80776;54903;27077	MI:0019-coimmunoprecipitation	GO:0060271;GO:0035869	cilium assembly;ciliary transition zone	None	None	32726168	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	B9 domain-containing protein 2;Tectonic-like complex member MKS1;B9 domain-containing protein 1	B9D2;MKS1;B9D1	MKSR2;None;MKSR1
7995	E2F1-HDAC2-PA2G4-RB1 complex	Human	E2F1-EBP1-HDAC2-RB1 complex	HeLa cells	P06400;Q01094;Q92769;Q9UQ80	5925;1869;3066;5036	MI:0007-anti tag coimmunoprecipitation;MI:0225-chromatin immunoprecipitation array;MI:0413-electrophoretic mobility shift assay	GO:0005634;GO:0045892	nucleus;negative regulation of DNA-templated transcription	70.10;11.02.03.04.03	nucleus;transcription repression	15073182	The E2F1-HDAC2-PA2G4-RB1 complex binds to the E2F promoter elements as demonstrated by EMSA, DNA affinity precipitation, and chromatin immunoprecipitation (ChIP) assays. HRG enhanced the ability of PA2G4 to bind to E2F consensus elements and to repress transcription.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Retinoblastoma-associated protein;Transcription factor E2F1;Histone deacetylase 2;Proliferation-associated protein 2G4	RB1;E2F1;HDAC2;PA2G4	None;RBBP3;None;EBP1
7996	HSPA8-PA2G4-STUB1 complex	Human	CHIP-EBP1-HSP70 complex	HEK293T cells	P11142;Q9UNE7;Q9UQ80	3312;10273;5036	MI:0007-anti tag coimmunoprecipitation	GO:0010498	proteasomal protein catabolic process	None	None	24651434	P42 PA2G4 (Ebp1) regulates the proteasomal degradation of the p85 regulatory subunit of PI3K by recruiting a chaperone-E3 ligase complex HSP70/CHIP.	P42 PA2G4 (Ebp1) represses tumorigenesis in vivo through downregulation of p85.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Heat shock cognate 71 kDa protein;E3 ubiquitin-protein ligase CHIP;Proliferation-associated protein 2G4	HSPA8;STUB1;PA2G4	HSC70 HSP73 HSPA10;CHIP;EBP1
7997	ILF3-PA2G4 complex	Human	DRBP76-EBP1 complex	Raji cells	Q12906;Q9UQ80	3609;5036	MI:0004-affinity chromatography technology;MI:0226-ion exchange chromatography;MI:0412-electrophoretic mobility supershift assay	GO:0003729;GO:0010468	mRNA binding;regulation of gene expression	None	None	21624892	3'UTRs of MHCII mRNAs bind the ILF3-PA2G4 complex.  The ILF3-PA2G4 complex plays a role in regulating the expression of HLA-DRA, HLA-DRB1 and HLA-DQA1.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Interleukin enhancer-binding factor 3;Proliferation-associated protein 2G4	ILF3;PA2G4	DRBF MPHOSPH4 NF90;EBP1
7998	MEIG1-PACRG complex	Human	None	In vitro	Q5JSS6;Q96M98	644890;135138	MI:0114-x-ray crystallography;MI:0416-fluorescence microscopy	GO:1905198;GO:0007288	manchette assembly;sperm axoneme assembly	None	None	33529594	The MEIG1-PACRG complex in the manchette, a unique structure at the base of elongating spermatids, is essential for building the sperm flagella.	None	Association between MEIG1 and PACRG was also shown in mice by fluorescence microscopy (PMID: 25715396)	Homo sapiens (Human);Homo sapiens (Human)	Meiosis expressed gene 1 protein homolog;Parkin coregulated gene protein	MEIG1;PACRG	None;GLUP
8000	BAX-BCL2L11-PACS2-TNFRSF10B-TNFSF10 complex	Human	BAX-BIM-PACS2-DR5-TRAIL complex; PIXosome	Huh-7 cells	O14763;O43521;P50591;Q07812;Q86VP3	8795;10018;8743;581;23241	MI:0019-coimmunoprecipitation	GO:0006915;GO:0005764	apoptotic process;lysosome	40.10.02;70.25	apoptosis (type I programmed cell death);vacuole or lysosome	22645134	TRAIL induces formation of the BAX-BCL2L11-PACS2-TNFRSF10B-TNFSF10 complex. This complex is required for lysosomal membrane permeabilization, cathepsin B release, and cell death.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Tumor necrosis factor receptor superfamily member 10B;Bcl-2-like protein 11;Tumor necrosis factor ligand superfamily member 10;Apoptosis regulator BAX;Phosphofurin acidic cluster sorting protein 2	TNFRSF10B;BCL2L11;TNFSF10;BAX;PACS2	DR5 KILLER TRAILR2 TRICK2 ZTNFR9;BIM;APO2L TRAIL;BCL2L4;KIAA0602,PACS1L
8002	Translin-Trax complex	Human	TSN-TSNAX complex	human genes expressed in  E. coli BL21	Q15631;Q99598	7247;7257	MI:0004-affinity chromatography technology;MI:0071-molecular sieving	GO:0003677;GO:0009749;GO:0005737;GO:0005634	DNA binding;response to glucose;cytoplasm;nucleus	16.03.01;70.03;70.10	DNA binding;cytoplasm;nucleus	15919079	The Translin-Trax complex functions as glucose response element binding protein and exists in both liver cytosol and nucleus of rats fed a high-carbohydrate diet. The complex binds to single-stranded and double-stranded DNA.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Translin;Translin-associated protein X	TSN;TSNAX	None;TRAX
8004	Cathepsin A-beta-galactosidase complex	Human	CTSA-GLB1 complex; GAL-CP complex	placenta	P10619;P16278	5476;2720	MI:0004-affinity chromatography technology;MI:0071-molecular sieving	GO:0005764;GO:0065003;GO:0015925	lysosome;protein-containing complex assembly;galactosidase activity	70.25	vacuole or lysosome	8363614	The GAL-CP complex may play a role in the lysosome being a matrix on which several lysosomal enzymes can associate.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Lysosomal protective protein;Beta-galactosidase	CTSA;GLB1	PPGB;ELNR1
8005	Cathepsin A-beta-galactosidase-neuraminidase complex	Human	CTSA-GLB1-NEU1 complex	placenta	P10619;P16278;Q99519	5476;2720;4758	MI:0004-affinity chromatography technology	GO:0005764;GO:0015925	lysosome;galactosidase activity	70.25	vacuole or lysosome	8053688	Cathepsin A (lysosomal protective protein, CTSA) stabilizes beta-galactosidase and activates neuraminidase by forming a high-molecular-weight lysosomal complex.	Galactosialidosis is caused by absence of structural interaction between cathepsin A, beta-Gal and neuraminidase (PMID: 1907282).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Lysosomal protective protein;Beta-galactosidase;Sialidase-1	CTSA;GLB1;NEU1	PPGB;ELNR1;NANH
8006	CTBP1-EP300-FOXO3 complex	Human	None	U2OS cells	O43524;Q09472;Q13363	2309;2033;1487	MI:0019-coimmunoprecipitation;MI:0397-two hybrid array	GO:0006355;GO:0042981	regulation of DNA-templated transcription;regulation of apoptotic process	11.02.03.04	transcriptional control	31074088	The CTBP1-EP300-FOXO3 complex specifically binds to the promoters of Bax and Bim and negatively regulates their expression in osteosarcoma cells.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Forkhead box protein O3;Histone acetyltransferase p300;C-terminal-binding protein 1	FOXO3;EP300;CTBP1	FKHRL1, FOXO3A;P300;CTBP
8007	APC/C complex	Human	Anaphase-promoting complex/cyclosome	HeLa cells, arrested in mitosis	P30260;Q13042;Q9H1A4;Q9UJX2;Q9UJX3;Q9UJX4;Q9UJX6	996;8881;64682;8697;51434;51433;29882	MI:0004-affinity chromatography technology;MI:0226-ion exchange chromatography	GO:0007059;GO:0010458	chromosome segregation;exit from mitosis	10.03.04.05	chromosome segregation/division	11859075	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cell division cycle protein 27 homolog;Cell division cycle protein 16 homolog;Anaphase-promoting complex subunit 1;Cell division cycle protein 23 homolog;Anaphase-promoting complex subunit 7;Anaphase-promoting complex subunit 5;Anaphase-promoting complex subunit 2	CDC27;CDC16;ANAPC1;CDC23;ANAPC7;ANAPC5;ANAPC2	ANAPC3 D0S1430E D17S978E;ANAPC6;TSG24;ANAPC8;APC7;APC5;APC2 KIAA1406
8008	APC/C complex, 1.5 MDa	Human	Anaphase-promoting complex/cyclosome, 1.5 MDa	HeLa cells	O14519;P30260;Q13042;Q8NHZ8;Q9H1A4;Q9NYG5;Q9UJX2;Q9UJX3;Q9UJX4;Q9UJX5;Q9UJX6	8099;996;8881;246184;64682;51529;8697;51434;51433;29945;29882	MI:0004-affinity chromatography technology	GO:0000278;GO:0005634;GO:0031145;GO:0016567;GO:0007059;GO:0010458	mitotic cell cycle;nucleus;anaphase-promoting complex-dependent catabolic process;protein ubiquitination;chromosome segregation;exit from mitosis	10.03.01.01;70.10;14.07.05;10.03.04.05	mitotic cell cycle;nucleus;modification by ubiquitination, deubiquitination;chromosome segregation/division	16275329	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cyclin-dependent kinase 2-associated protein 1;Cell division cycle protein 27 homolog;Cell division cycle protein 16 homolog;Anaphase-promoting complex subunit CDC26;Anaphase-promoting complex subunit 1;Anaphase-promoting complex subunit 11;Cell division cycle protein 23 homolog;Anaphase-promoting complex subunit 7;Anaphase-promoting complex subunit 5;Anaphase-promoting complex subunit 4;Anaphase-promoting complex subunit 2	CDK2AP1;CDC27;CDC16;CDC26;ANAPC1;ANAPC11;CDC23;ANAPC7;ANAPC5;ANAPC4;ANAPC2	CDKAP1 DOC1;ANAPC3 D0S1430E D17S978E;ANAPC6;ANAPC12 C9orf17;TSG24;None;ANAPC8;APC7;APC5;APC4;APC2 KIAA1406
8009	GCP4-GCP5-GCP6 core complex	Human	GCP4/5/6 sub-complex; GCP4-5-6 core complex of gamma-TuRC; GCP4-5-6 sub-complex of gamma-tubulin ring complex; TUBGCP4-TUBGCP5-TUBGCP6 complex	HeLa cells	Q96RT7;Q96RT8;Q9UGJ1	85378;114791;27229	MI:0019-coimmunoprecipitation	GO:0005737;GO:0005813;GO:0007020	cytoplasm;centrosome;microtubule nucleation	70.03;70.05	cytoplasm;centrosome	32317396	Gamma-TuRC-specific GCP4, GCP5 and GCP6 form a core complex resistant to treatment with high concentrations of KCl. The GCP4/5/6 sub-complex promotes the assembly of gamma-tubulin ring complexes.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Gamma-tubulin complex component 6;Gamma-tubulin complex component 5;Gamma-tubulin complex component 4	TUBGCP6;TUBGCP5;TUBGCP4	GCP6 KIAA1669;GCP5, KIAA1899;76P, GCP4
8010	Aurora A-TPX2 complex	Human	None	U2OS cells	O14965;Q9ULW0	6790;22974	MI:0019-coimmunoprecipitation	GO:0071228;GO:0000132	cellular response to tumor cell;establishment of mitotic spindle orientation	None	None	33275894	Aurora-A/TPX2 complex controls mitotic spindle orientation.	Aurora-A and its activator TPX2 are frequently overexpressed in cancer. (PMID: 20708655)	None	Homo sapiens (Human);Homo sapiens (Human)	Aurora kinase A;Targeting protein for Xklp2	AURKA;TPX2	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6;C20orf1 C20orf2 DIL2 HCA519
8011	Aurora A-TPX2-NuMA complex	Human	None	U2OS cells	O14965;Q14980;Q9ULW0	6790;4926;22974	MI:0019-coimmunoprecipitation	GO:0000132;GO:0071228	establishment of mitotic spindle orientation;cellular response to tumor cell	None	None	33275894	TPX2 acts as a platform for Aurora-A regulation of NuMA. (PMID: 33275894)	Aurora-A and its activator TPX2 are frequently overexpressed in cancer. (PMID: 20708655)	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Aurora kinase A;Nuclear mitotic apparatus protein 1;Targeting protein for Xklp2	AURKA;NUMA1;TPX2	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6;NMP22 NUMA;C20orf1 C20orf2 DIL2 HCA519
8012	CTBP2-EP300-RUNX2 complex	Human	None	HOB-1 primary osteoblast cells	P56545;Q09472;Q13950	1488;2033;860	MI:0007-anti tag coimmunoprecipitation;MI:0402-chromatin immunoprecipitation assay	GO:0006355;GO:0030278	regulation of DNA-templated transcription;regulation of ossification	11.02.03.04	transcriptional control	30585266	NADH levels determine the expression of bone formation and development of related genes through affecting the dissociation or binding of CTBP2 to the EP300-RUNX2 complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	C-terminal-binding protein 2;Histone acetyltransferase p300;Runt-related transcription factor 2	CTBP2;EP300;RUNX2	None;P300;AML3 CBFA1 OSF2 PEBP2A
8013	EP300-RUNX2 complex	Human	None	HOB-1 cells.	Q09472;Q13950	2033;860	MI:0007-anti tag coimmunoprecipitation	GO:0030278;GO:0006355	regulation of ossification;regulation of DNA-templated transcription	11.02.03.04	transcriptional control	30585266	NADH levels determine the expression of bone formation and development of related genes through affecting the dissociation or binding of CTBP2 to the EP300-RUNX2 complex.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Histone acetyltransferase p300;Runt-related transcription factor 2	EP300;RUNX2	P300;AML3 CBFA1 OSF2 PEBP2A
8014	TULP3-Intraflagellar transport complex A	Human	TULP3-IFT-A complex	HEK293-T cells	O75386;Q7Z4L5;Q8NEZ3;Q96FT9;Q96RY7;Q9HBG6;Q9P2L0	7289;79809;57728;112752;9742;55764;57539	MI:0004-affinity chromatography technology;MI:0069-mass spectrometry studies of complexes	GO:0035720;GO:0005929;GO:0042073	intraciliary anterograde transport;cilium;intraciliary transport	None	None	24563533	The IFT-A complex is a distinct submodule of the IFT/lebercilin protein complex. TULP3 has been identified as a potential new member of the IFT-A complex. (PMID: 24563533)	Disruption of the intraflagellar protein transport causes Leber congenital amaurosis. (PMID: 21606596)	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Tubby-related protein 3;Tetratricopeptide repeat protein 21B;WD repeat-containing protein 19;Intraflagellar transport protein 43 homolog;Intraflagellar transport protein 140 homolog;Intraflagellar transport protein 122 homolog;WD repeat-containing protein 35	TULP3;TTC21B;WDR19;IFT43;IFT140;IFT122;WDR35	TUBL3;IFT139 KIAA1992;IFT144 KIAA1638;C14orf179;KIAA0590 WDTC2;SPG WDR10 WDR140;IFT121, KIAA1336
8015	CTLH complex, submodule of the IFT/lebercilin complex	Human	C-terminal to LisH complex	HEK293-T cells	O43464;P62699;Q6VN20;Q7L5Y9;Q8IUR7;Q8IVV7;Q96HS1;Q96S59;Q9H7D7;Q9H871;Q9NWU2;Q9UL63	27429;51646;57610;10296;25852;79018;192111;10048;80232;64795;54994;4289	MI:0004-affinity chromatography technology;MI:0069-mass spectrometry studies of complexes	GO:0043130;GO:0006511	ubiquitin binding;ubiquitin-dependent protein catabolic process	14.13.01.01	proteasomal degradation (ubiquitin/proteasomal pathway)	24563533	The CTLH complex is a distinct submodule of the IFT/lebercilin protein complex. (PMID: 24563533)	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Serine protease HTRA2, mitochondrial;Protein yippee-like 5;Ran-binding protein 10;E3 ubiquitin-protein transferase MAEA;Armadillo repeat-containing protein 8;Glucose-induced degradation protein 4 homolog;Serine/threonine-protein phosphatase PGAM5, mitochondrial;Ran-binding protein 9;WD repeat-containing protein 26;E3 ubiquitin-protein transferase RMND5A;Glucose-induced degradation protein 8 homolog;Muskelin	HTRA2;YPEL5;RANBP10;MAEA;ARMC8;GID4;PGAM5;RANBP9;WDR26;RMND5A;GID8;MKLN1	OMI PRSS25;None;KIAA1464;EMP;None;C17orf39,VID24;None;RANBPM;CDW2 MIP2;None;C20orf11 TWA1;None
8016	Dynein light chain complex (DYNLL1, DYNLL2)	Human	None	HEK293-T cells	P63167;Q96FJ2	8655;140735	MI:0004-affinity chromatography technology;MI:0069-mass spectrometry studies of complexes	GO:0060271	cilium assembly	None	None	24563533	The  Dynein light chain complex is a distinct submodule of the IFT/lebercilin protein complex. (PMID: 24563533)	None	None	Homo sapiens (Human);Homo sapiens (Human)	Dynein light chain 1, cytoplasmic;Dynein light chain 2, cytoplasmic	DYNLL1;DYNLL2	DLC1 DNCL1 DNCLC1 HDLC1;DLC2
8018	RAD18-SETD1A complex	Human	None	HEK-293 cell	O15047;Q9NS91	9739;56852	MI:0019-coimmunoprecipitation	GO:0005634;GO:0006281	nucleus;DNA repair	70.10;10.01.05.01	nucleus;DNA repair	31076518	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Histone-lysine N-methyltransferase SETD1A;E3 ubiquitin-protein ligase RAD18	SETD1A;RAD18	KIAA0339 KMT2F SET1 SET1A;RNF73
8019	PACSIN1-PICK1 complex	Human	None	HEK 293T cells	Q9BY11;Q9NRD5	29993;9463	MI:0007-anti tag coimmunoprecipitation;MI:0416-fluorescence microscopy	GO:0048471;GO:0006897;GO:0060292	perinuclear region of cytoplasm;endocytosis;long-term synaptic depression	20.09.18.09.01	endocytosis	23918399	The PACSIN1-PICK1 complex is required for the activity-dependent internalization of AMPARs and for the expression of long-term depression in the cerebellum. The interaction between PICK1 and PACSIN1 is regulated by PACSIN1 phosphorylation.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Protein kinase C and casein kinase substrate in neurons protein 1;PRKCA-binding protein	PACSIN1;PICK1	KIAA1379;PRKCABP
8020	PACSIN2-PICK1 complex	Human	None	HEK 293T cells	Q9NRD5;Q9UNF0	9463;11252	MI:0007-anti tag coimmunoprecipitation	GO:0060292	long-term synaptic depression	None	None	23918399	PICK1 is a phosphorylation-regulated partner for PACSIN2 and that their interaction is required for cerebellar  long-term depression (LTD).	None	None	Homo sapiens (Human);Homo sapiens (Human)	PRKCA-binding protein;Protein kinase C and casein kinase substrate in neurons protein 2	PICK1;PACSIN2	PRKCABP;None
8021	PACSIN3-PICK1 complex	Human	None	HEK 293T cells	Q9NRD5;Q9UKS6	9463;29763	MI:0007-anti tag coimmunoprecipitation	None	None	None	None	23918399	The expression of PACSIN3 is restricted to the muscle, heart, and lung.	None	None	Homo sapiens (Human);Homo sapiens (Human)	PRKCA-binding protein;Protein kinase C and casein kinase substrate in neurons protein 3	PICK1;PACSIN3	PRKCABP;None
8022	SRCAP-containing complex	Human	None	HeLa S3 cells	O95619;O96019;Q6ZRS2;Q9GZN1;Q9NPF5;Q9Y230;Q9Y265	8089;86;10847;64431;55929;10856;8607	MI:0006-anti bait coimmunoprecipitation;MI:0071-molecular sieving;MI:0226-ion exchange chromatography	GO:0005634;GO:0006338	nucleus;chromatin remodeling	70.10	nucleus	16634648	The SRCAP complex facilitates exchange of H2A.Z/H2B dimers into nucleosomes. (PMID: 16634648)	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	YEATS domain-containing protein 4;Actin-like protein 6A;Helicase SRCAP;Actin-related protein 6;DNA methyltransferase 1-associated protein 1;RuvB-like 2;RuvB-like 1	YEATS4;ACTL6A;SRCAP;ACTR6;DMAP1;RUVBL2;RUVBL1	GAS41;BAF53 BAF53A INO80K;KIAA0309;None;KIAA1425;INO80J TIP48 TIP49B;INO80H NMP238 TIP49 TIP49A
8028	CD4 receptor complex	Human	None	CEM cells	P01730;P02786;P06239;P07437;P08575;P08670;P35579;Q14761;Q9BQE3	920;7037;3932;203068;5788;7431;4627;5790;84790	MI:0019-coimmunoprecipitation	GO:0042110;GO:0006955	T cell activation;immune response	36.25.16	immune response	18205604	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	T-cell surface glycoprotein CD4;Transferrin receptor protein 1;Tyrosine-protein kinase Lck;Tubulin beta chain;Receptor-type tyrosine-protein phosphatase C;Vimentin;Myosin-9;Protein tyrosine phosphatase receptor type C-associated protein;Tubulin alpha-1C chain	CD4;TFRC;LCK;TUBB;PTPRC;VIM;MYH9;PTPRCAP;TUBA1C	None;None;None;TUBB5;CD45;None;None;LPAP;TUBA6
8029	MBL-I complex	Human	None	serum	O00187-2;P11226;P48740	10747;4153;5648	MI:0004-affinity chromatography technology	GO:0045087;GO:0001867	innate immune response;complement activation, lectin pathway	36.25.16.01	innate immune response (invertebrates and vertebrates)	21371091	MBL copurified with MASP-1 and sMAP, the truncated form of MASP2. The MBL-I complex activates C2 of the complement system, but does not activate C4 due to the absence of MASP-2.	None	sMAP (O00187-2) is a splice variant of MASP2.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Isoform 2 of Mannan-binding lectin serine protease 2;Mannose-binding protein C;Mannan-binding lectin serine protease 1	MASP2;MBL2;MASP1	None;COLEC1,MBL;CRARF CRARF1 PRSS5
8034	MBL-II complex	Human	None	plasma	O00187;P11226;P48740-2	10747;4153;5648	MI:0004-affinity chromatography technology;MI:0029-cosedimentation through density gradient;MI:0226-ion exchange chromatography	GO:0001867;GO:0045087	complement activation, lectin pathway;innate immune response	36.25.16.01	innate immune response (invertebrates and vertebrates)	11485744	MBL-II complexes have the ability to activate C4 of the complement system.	None	MASP-3 (P48740-2) is a splice variant of MASP1.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mannan-binding lectin serine protease 2;Mannose-binding protein C;Isoform 2 of Mannan-binding lectin serine protease 1	MASP2;MBL2;MASP1	None;COLEC1,MBL;CRARF CRARF1 PRSS5
8043	SLC52A3-TMEM237 complex	Human	None	intestinal epithelial cells	Q96Q45;Q9NQ40	65062;113278	MI:0019-coimmunoprecipitation	GO:0032218	riboflavin transport	None	None	30892938	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Transmembrane protein 237;Solute carrier family 52, riboflavin transporter, member 3	TMEM237;SLC52A3	ALS2CR4;C20orf54 RFT2 RFVT3
8052	Tim-Tipin complex	Human	Rxra-Per2 complex	HEK293T cells	Q9BVW5;Q9UNS1	54962;8914	MI:0007-anti tag coimmunoprecipitation	GO:0042770	signal transduction in response to DNA damage	None	None	17296725	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	TIMELESS-interacting protein;Protein timeless homolog	TIPIN;TIMELESS	None;TIM,TIM1,TIMELESS1
8055	CRY2-TIM complex	Human	None	HEK293T cells	Q49AN0;Q9UNS1	1408;8914	MI:0007-anti tag coimmunoprecipitation	GO:0007623	circadian rhythm	None	None	15798197	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cryptochrome-2;Protein timeless homolog	CRY2;TIMELESS	KIAA0658;TIM,TIM1,TIMELESS1
8056	ATR-ATRIP-TIM complex	Human	None	HEK293T cells	Q13535;Q8WXE1;Q9UNS1	545;84126;8914	MI:0007-anti tag coimmunoprecipitation	GO:0007623	circadian rhythm	None	None	15798197	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein kinase ATR;ATR-interacting protein;Protein timeless homolog	ATR;ATRIP;TIMELESS	FRP1;AGS1;TIM,TIM1,TIMELESS1
8057	Distal centriole complex	Human	DISCO complex	RPE1 cells	O75665;Q2KHM9;Q8WXW3	8481;9851;10464	MI:0019-coimmunoprecipitation	GO:0005814;GO:0060271;GO:1905353	centriole;cilium assembly;ciliary transition fiber assembly	None	None	34241634	The distal centriole complex is required to assemble the distal appendages. The complex consists of three proteins, MNR, OFD1, and CEP90. MNR forms the innermost ring at the distal centriole and recruits OFD1, together with CEP90. CEP90 is a key component of the centriolar satellites and of the distal end of centrioles. CEP90 regulates mother centriole function and recruits CEP83 to initiate distal appendage assembly at the mother centriole (PMID: 34830133).	The Distal centriole complex (DISCO) components CEP90, MNR, and OFD1 underlie human ciliopathies. (PMID:34241634)	PIBF1 is alternatively spliced, the longest splice variant is CEP90, which is the canonical sequence in UniProt.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Centriole and centriolar satellite protein OFD1;Protein moonraker;Progesterone-induced-blocking factor 1	OFD1;KIAA0753;PIBF1	CXorf5;MNR OFIP;C13orf24,PIBF
8058	MAP1LC3A-OFD1-PCM1 complex	Human	None	HEK293T cells	O75665;Q15154;Q9H492	8481;5108;84557	MI:0019-coimmunoprecipitation	GO:0060271;GO:0034451	cilium assembly;centriolar satellite	None	None	24089205	None	Mutations in OFD1 cause Orofaciodigital syndrome I and other ciliopathies.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Centriole and centriolar satellite protein OFD1;Pericentriolar material 1 protein;Microtubule-associated proteins 1A/1B light chain 3A	OFD1;PCM1;MAP1LC3A	CXorf5;None;None
8059	LYN-PAG1-STAT3 complex	Human	Signalosome	SUDHL6 cells	P07948;P40763;Q9NWQ8	4067;6774;55824	MI:0019-coimmunoprecipitation	GO:0045121;GO:0008219	membrane raft;cell death	40.10	cell death	18070987	B-non-Hodgkin lymphomas use a raft-associated signalosome made of the constitutively active LYN kinase, the tyrosine phosphorylated PAG1 adaptor, and tyrosine phosphorylated STAT3 transcription factor.	An oncogenic role for Lyn was shown after exposure of B-NHL lines to Lyn inhibitors.	Stable association of the signalosome with B-NHL rafts requires (1) a Lyn kinase (auto)phosphorylated in its regulatory and active site tyrosines, (2) a PAG adaptor phosphorylated at tyrosine 317 and bound to Lyn SH2 via phosphotyrosine 299 and neighboring residues, and (3) a tyrosine phosphorylated STAT3 linked via SH2 to the regulatory, C-terminal tyrosine of Lyn.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Tyrosine-protein kinase Lyn;Signal transducer and activator of transcription 3;Phosphoprotein associated with glycosphingolipid-enriched microdomains 1	LYN;STAT3;PAG1	JTK8;APRF;CBP,PAG
8060	LYN-PAG1 complex	Human	Signalosome	Raji, DoHH2, and SUDHL6 cells	P07948;Q9NWQ8	4067;55824	MI:0019-coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0045121;GO:0008283	membrane raft;cell population proliferation	None	None	18070987	The Lyn-Cbp/PAG signalosome appears to control proliferation and survival in most B-non-Hodgkin lymphomas.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Tyrosine-protein kinase Lyn;Phosphoprotein associated with glycosphingolipid-enriched microdomains 1	LYN;PAG1	JTK8;CBP,PAG
8061	CSK-FYN-PAG1 complex	Human	None	anergic T cells	P06241;P41240;Q9NWQ8	2534;1445;55824	MI:0019-coimmunoprecipitation	GO:0002870	T cell anergy	None	None	17389760	In anergic T cells,  PAG1 is hyperphosphorylated at the CSK binding site, leading to enhanced CSK recruitment and inhibitory tyrosine phosphorylation within FYN. PAG1, a transmembrane adaptor that localizes within the lipid rafts, negatively regulates Src kinase activity by recruiting the C-terminal Src kinase (Csk) to the membrane.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Tyrosine-protein kinase Fyn;Tyrosine-protein kinase CSK;Phosphoprotein associated with glycosphingolipid-enriched microdomains 1	FYN;CSK;PAG1	None;None;CBP,PAG
8062	FYN-PAG1-KHDRBS1-RASA1 complex	Human	FYN-PAG1-SAM68-RasGAP complex	anergic T cells	P06241;P20936;Q07666;Q9NWQ8	2534;5921;10657;55824	MI:0019-coimmunoprecipitation	GO:0002870	T cell anergy	None	None	17389760	The presence of this multimolecular complex (PAG1, FYN, KHDRBS1, and RASA1) within lipid rafts is ideally positioned to block Ras activation, because Ras-GDP is itself raft-localized. Therefore, an enhanced recruitment of RasGAP to this membrane compartment would stimulate the rapid hydrolysis of any Ras-GTP that forms, thus effectively shutting down Ras.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Tyrosine-protein kinase Fyn;Ras GTPase-activating protein 1;KH domain-containing, RNA-binding, signal transduction-associated protein 1;Phosphoprotein associated with glycosphingolipid-enriched microdomains 1	FYN;RASA1;KHDRBS1;PAG1	None;GAP RASA;SAM68;CBP,PAG
8063	FYN-KHDRBS1-PAG1 complex	Human	FYN-SAM68-PAG1 complex	anergic T cells	P06241;Q07666;Q9NWQ8	2534;10657;55824	MI:0019-coimmunoprecipitation	GO:0002870	T cell anergy	None	None	17389760	None	None	In resting T cells, the cytoplasmic pool of KHDRBS1 (Sam68) seems to be constitutively associated with PAG1 and FYN, but not RasGAP (see FYN-KHDRBS1-PAG1-RASA1 complex; complex 8062).	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Tyrosine-protein kinase Fyn;KH domain-containing, RNA-binding, signal transduction-associated protein 1;Phosphoprotein associated with glycosphingolipid-enriched microdomains 1	FYN;KHDRBS1;PAG1	None;SAM68;CBP,PAG
8064	CSK-PAG1 complex	Human	None	Jurkat T cells	P41240;Q9NWQ8	1445;55824	MI:0007-anti tag coimmunoprecipitation	GO:0042110;GO:0045121	T cell activation;membrane raft	None	None	11390365	In resting peripheral T cells, Csk is constitutively present in lipid rafts through an interaction with the Csk SH2-binding protein, PAG1. Upon triggering of the T cell antigen receptor (TCR), PAG1 is rapidly dephosphorylated leading to dissociation of Csk from lipid rafts.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Tyrosine-protein kinase CSK;Phosphoprotein associated with glycosphingolipid-enriched microdomains 1	CSK;PAG1	None;CBP,PAG
8065	FYN-PAG1 complex	Human	None	Jurkat cells	P06241;Q9NWQ8	2534;55824	MI:0019-coimmunoprecipitation	None	None	None	None	10790433	In contrast to the CSK-PAG1 complex, formation of the FYN-PAG1 complex is not dependent on tyrosine phosphorylation of PAG1.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Tyrosine-protein kinase Fyn;Phosphoprotein associated with glycosphingolipid-enriched microdomains 1	FYN;PAG1	None;CBP,PAG
8066	MSN-PAG1-SLC9A3R1 complex	Human	CBP-EBP50-ERM complex	Jurkat cells	O14745;P26038;Q9NWQ8	9368;4478;55824	MI:0019-coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:2000520;GO:0042110	regulation of immunological synapse formation;T cell activation	None	None	11777944	T cell activation induces dissociation of the MSN-PAG1-SLC9A3R1 complex and immune synapse formation, suggesting that the anchorage through PAG1-SLC9A3R1 serves as negative regulation of immune synapse formation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Na(+)/H(+) exchange regulatory cofactor NHE-RF1;Moesin;Phosphoprotein associated with glycosphingolipid-enriched microdomains 1	SLC9A3R1;MSN;PAG1	NHERF NHERF1;None;CBP,PAG
8067	PAGR1-PAXIP1 complex	Human	PA1-PTIP complex	293T cells	Q6ZW49;Q9BTK6	22976;79447	MI:0007-anti tag coimmunoprecipitation;MI:0416-fluorescence microscopy	GO:0006281;GO:0010212	DNA repair;response to ionizing radiation	10.01.05.01	DNA repair	19124460	The PAGR1-PAXIP1 complex is required for cell survival after ionizing radiation.	None	None	Homo sapiens (Human);Homo sapiens (Human)	PAX-interacting protein 1;PAXIP1-associated glutamate-rich protein 1	PAXIP1;PAGR1	PAXIP1L PTIP;C16orf53, PA1
8068	BRCA1-BRCA2-PALB2 complex	Human	None	HEK 293 T cells	P38398;P51587;Q86YC2	672;675;79728	MI:0019-coimmunoprecipitation;MI:0071-molecular sieving	GO:0000724	double-strand break repair via homologous recombination	None	None	19369211	The BRCA1-BRCA2-PALB2 complex is important for the maintenance of genomic stability via homologous recombination repair.	BRCA1 mutations identified in cancer patients disrupted the specific interaction between BRCA1 and PALB2.	PALB2, the partner and localizer of BRCA2, binds directly to BRCA1, and serves as the molecular scaffold in the formation of the BRCA1-BRCA2-PALB2 complex.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Breast cancer type 1 susceptibility protein;Breast cancer type 2 susceptibility protein;Partner and localizer of BRCA2	BRCA1;BRCA2;PALB2	RNF53;FACD FANCD1;FANCN
8069	PALB2-RAD51 complex	Human	None	In vitro	Q06609;Q86YC2	5888;79728	MI:0007-anti tag coimmunoprecipitation	GO:0006281	DNA repair	10.01.05.01	DNA repair	20871616	PALB2 enhances RAD51\u2019s ability to form the D loop as part of homologous recombination repair of DNA double-strand breaks.	None	None	Homo sapiens (Human);Homo sapiens (Human)	DNA repair protein RAD51 homolog 1;Partner and localizer of BRCA2	RAD51;PALB2	RAD51A RECA;FANCN
8070	PALB2-RAD51AP1 complex	Human	None	HeLa cells; U2OS cells	Q86YC2;Q96B01	79728;10635	MI:0007-anti tag coimmunoprecipitation;MI:0416-fluorescence microscopy	GO:0006281	DNA repair	10.01.05.01	DNA repair	20871616	The PALB2-RAD51AP1 complex enhances the recombinase function of RAD51.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Partner and localizer of BRCA2;RAD51-associated protein 1	PALB2;RAD51AP1	FANCN;PIR51
8071	PAN2-PAN3-PABPC1 complex	Human	None	COS-7 cells	P11940;Q504Q3;Q58A45	26986;9924;255967	MI:0007-anti tag coimmunoprecipitation	GO:0004535;GO:0005737	poly(A)-specific ribonuclease activity;cytoplasm	70.03	cytoplasm	14583602	The PAN complex is a poly(A)-specific exoribonuclease that is stimulated by PABPC1 in the cytoplasm.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Polyadenylate-binding protein 1;PAN2-PAN3 deadenylation complex catalytic subunit PAN2;PAN2-PAN3 deadenylation complex subunit PAN3	PABPC1;PAN2;PAN3	PAB1 PABP PABP1 PABPC2;KIAA0710 USP52;None
8072	AHCYL1-CPSF complex	Human	AHCYL1-CPSF1-CPSF2-CPSF3-CPSF4-FIP1L1 complex	293EBNA cells ; COS-7 cells	O43865;O95639;Q10570;Q6UN15;Q9P2I0;Q9UKF6	10768;10898;29894;None;53981;51692	MI:0007-anti tag coimmunoprecipitation	None	None	None	None	19224921	IRBIT (AHCYL1) interactes with CPSF and is recruited to an exogenous polyadenylation signal-containing RNA. The main target for IRBIT in CPSF is Fip1 (FIP1L1) subunit, and the phosphorylation of the serine-rich region of IRBIT was required both for direct association with Fip1 in vitro and for redistribution of Fip1 into the cytoplasm of intact cells.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	S-adenosylhomocysteine hydrolase-like protein 1;Cleavage and polyadenylation specificity factor subunit 4;Cleavage and polyadenylation specificity factor subunit 1;Pre-mRNA 3'-end-processing factor FIP1;Cleavage and polyadenylation specificity factor subunit 2;Cleavage and polyadenylation specificity factor subunit 3	AHCYL1;CPSF4;CPSF1;FIP1L1;CPSF2;CPSF3	DCAL IRBIT XPVKONA;CPSF30, NAR, NEB1;CPSF160;FIP1, RHE;CPSF100, KIAA1367;CPSF73
8073	AHCYL1-FIP1L1-PAPOLA complex	Human	IRBIT-FIP-PAP complex	Sf9 cells	O43865;P51003;Q6UN15	10768;10914;None	MI:0007-anti tag coimmunoprecipitation	GO:0043631	RNA polyadenylation	None	None	19224921	Results suggest that IRBIT (AHCYL1) inhibits the polyadenylation activity of PAP (PAPOLA) and that this inhibition is directly correlated to the phosphorylation level of IRBIT.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	S-adenosylhomocysteine hydrolase-like protein 1;Poly(A) polymerase alpha;Pre-mRNA 3'-end-processing factor FIP1	AHCYL1;PAPOLA;FIP1L1	DCAL IRBIT XPVKONA;PAP;FIP1, RHE
8074	ARL3-RP2-UNC119 complex	Human	None	in vitro	O75695;P36405;Q13432	6102;403;9094	MI:0053-fluorescence polarization spectroscopy;MI:0091-chromatography technology	GO:0003924;GO:0009881;GO:0097733;GO:0007601	GTPase activity;photoreceptor activity;photoreceptor cell cilium;visual perception	34.11.01.03	visual transduction	18588884	None	Mutations in ARL3, RP2, and UNC119 cause retinitis pigmentosa (PMID: 28698599).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein XRP2;ADP-ribosylation factor-like protein 3;Protein unc-119 homolog A	RP2;ARL3;UNC119	None;ARFL3;RG4
8075	PARL-STOML2-YME1L1 complex	Human	SPY complex; PARL-SLP2-YME1L1 complex	FITR293T cells	Q96TA2;Q9H300;Q9UJZ1	10730;55486;30968	MI:0007-anti tag coimmunoprecipitation;MI:0276-blue native page	GO:0034982;GO:0035694;GO:0005739	mitochondrial protein processing;mitochondrial protein catabolic process;mitochondrion	70.16	mitochondrion	27737933	Association with SLP2 in the SPY complex regulates PARL-mediated processing of PTEN-induced kinase PINK1 and the phosphatase PGAM5 in mitochondria.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	ATP-dependent zinc metalloprotease YME1L1;Presenilins-associated rhomboid-like protein, mitochondrial;Stomatin-like protein 2, mitochondrial	YME1L1;PARL;STOML2	FTSH1,YME1L;PSARL;SLP2
8076	KIF4A-KIF14-KIF20A-KIF23-PRC1 complex	Human	None	HeLa cells	O43663;O95235;O95239;Q02241;Q15058	9055;10112;24137;9493;9928	MI:0004-affinity chromatography technology;MI:0069-mass spectrometry studies of complexes	GO:0000910	cytokinesis	10.03.03	cytokinesis (cell division) /septum formation and hydrolysis	16431929	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein regulator of cytokinesis 1;Kinesin-like protein KIF20A;Chromosome-associated kinesin KIF4A;Kinesin-like protein KIF23;Kinesin-like protein KIF14	PRC1;KIF20A;KIF4A;KIF23;KIF14	None;MKLP2 RAB6KIFL;KIF4;KNSL5 MKLP1;KIAA0042
8078	AGO2-PARN complex	Human	None	HCT116 cells	O95453;Q9UKV8	5073;27161	MI:0019-coimmunoprecipitation;MI:0416-fluorescence microscopy	GO:0000289;GO:0005737;GO:0005634	nuclear-transcribed mRNA poly(A) tail shortening;cytoplasm;nucleus	70.03;70.10	cytoplasm;nucleus	26400160	Both, AU-rich elements (AREs) and the adjacent miR-504/miR-125b regulatory signals at the TP53 3' UTR are necessary for PARN-mediated regulation of p53 expression. The complex was detected in both non-stress conditions and after UV treatment. However, deadenylation activity in nuclear extracts of HCT116 cells treated with control siRNA increased significantly after UV treatment.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Poly(A)-specific ribonuclease PARN;Protein argonaute-2	PARN;AGO2	DAN;EIF2C2
8079	CABLES1-TP53-TP73 complex	Human	None	U2-OS cells	O15350;P04637;Q8TDN4	7161;7157;91768	MI:0019-coimmunoprecipitation	GO:0008219;GO:0051726	cell death;regulation of cell cycle	40.10;10.03.01	cell death;mitotic cell cycle and cell cycle control	11706030	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Tumor protein p73;Cellular tumor antigen p53;CDK5 and ABL1 enzyme substrate 1	TP73;TP53;CABLES1	P73;P53;CABLES
8080	Outer dynein arm-docking complex	Human	None	HEK293 cells	A5D8V7;Q5T2S8;Q96M63;Q96NG3	115948;55130;93233;83538	MI:0019-coimmunoprecipitation;MI:0051-fluorescence technology	GO:0031514;GO:0003341	motile cilium;cilium movement	None	None	27486780	None	Mutations in the four subunits of this complex cause  primary ciliary dyskinesia (PMID:27486780).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Outer dynein arm-docking complex subunit 3;Outer dynein arm-docking complex subunit 2;Outer dynein arm-docking complex subunit 1;Outer dynein arm-docking complex subunit 4	ODAD3;ODAD2;ODAD1;ODAD4	CCDC151;ARMC4;CCDC114;TTC25
8081	Interleukin-23	Human	IL-23; IL-23 cytokine; IL12B-IL23A complex; p19p40 complex	HEK293T cells	P29460;Q9NPF7	3593;51561	MI:0019-coimmunoprecipitation	GO:0032609;GO:0061485;GO:0007259;GO:0006955;GO:0019221;GO:0038155	interferon-gamma production;memory T cell proliferation;receptor signaling pathway via JAK-STAT;immune response;cytokine-mediated signaling pathway;interleukin-23-mediated signaling pathway	30.01.05.01.01;36.25.16	JAK-STAT cascade;immune response	11114383	IL23A (p19) interacts with the p40 subunit of IL-12 (IL12B) to form the heterodimeric cytokine IL-23.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Interleukin-12 subunit beta;Interleukin-23 subunit alpha	IL12B;IL23A	NKSF2;SGRF
8082	Interleukin-12	Human	IL-12; IL-12 cytokine; NK cell stimulatory factor; NKSF cytokine; IL12A-IL12B complex; p35p40 complex	EBV-transformed human B lymphoblastoid cell line RPMI 8866	P29459;P29460	3592;3593	MI:0004-affinity chromatography technology;MI:0095-proteinchip(r) on a surface-enhanced laser desorption/ionization	GO:0032609;GO:0030101;GO:0006955;GO:0019221;GO:0035722;GO:0030217	interferon-gamma production;natural killer cell activation;immune response;cytokine-mediated signaling pathway;interleukin-12-mediated signaling pathway;T cell differentiation	36.25.16;43.03.07.02.01.02	immune response;T-cell	2504877	The complex was also confirmed by X-ray crystallography.(PMID: 10899108)	None	None	Homo sapiens (Human);Homo sapiens (Human)	Interleukin-12 subunit alpha;Interleukin-12 subunit beta	IL12A;IL12B	NKSF1;NKSF2
8083	IL-15Ralpha-IL-15 complex	Human	Interleukin-15Ralpha-interleukin-15 complex; IL-15-IL-15RA complex; IL15-IL15Ralpha complex; IL15-IL15RA complex	HEK293 cells	P40933;Q13261	3600;3601	MI:0006-anti bait coimmunoprecipitation	GO:0061485;GO:0006955;GO:0019221;GO:0035723;GO:0001866;GO:0001787;GO:0031347	memory T cell proliferation;immune response;cytokine-mediated signaling pathway;interleukin-15-mediated signaling pathway;NK T cell proliferation;natural killer cell proliferation;regulation of defense response	36.25.16	immune response	18055460	Binding of IL-15 and IL-15Ralpha leads to stabilization of IL-15 and enhanced biological function. (PMID: 18055460). It is discussed, that the primary role of the IL-15alpha chain is to confer high affinity binding. At high concentrations, IL-15, like IL-2, is able to signal through a complex of IL-2Rbeta and IL-2Rgamma in the absence of the alpha subunit (PMID: 8530383; 21603270). This complex has been also characterized by X-ray crystallography (PMID: 17643103).	None	None	Homo sapiens (Human);Homo sapiens (Human)	Interleukin-15;Interleukin-15 receptor subunit alpha	IL15;IL15RA	None;None
8084	IL-2Rbeta/gamma receptor-IL-15 complex	Human	Interleukin-2Rbeta/gamma receptor-interleukin-15 complex; IL-2Rbeta/gamma-IL-15 complex, IL-15-stimulated; IL2Rbeta/gamma complex; IL2RB-IL2RG complex; IL-15-IL-2Rbeta/gamma complex	YT cells; peripheral blood mononuclear cells; COS cells	P14784;P31785;P40933	3560;3561;3600	MI:0019-coimmunoprecipitation;MI:0030-cross-linking study	GO:0006955;GO:0019221;GO:0035723;GO:0032609;GO:0042098;GO:1900424;GO:0031347;GO:0070672	immune response;cytokine-mediated signaling pathway;interleukin-15-mediated signaling pathway;interferon-gamma production;T cell proliferation;regulation of defense response to bacterium;regulation of defense response;response to interleukin-15	36.25.16	immune response	8026467	IL-15, like IL-2, can induce the dimerization of soluble beta and gamma IL-2receptor subunits (PMID: 8026467). IL-15-dependent, but IL-15Ralpha-independent signaling via the IL-2Rbeta/gamma dimeric complex is sufficient for the induction of IFNgamma from sources other than NK/NKT cells to control bacterial pathogens (PMID: 34956227). IL-15R alpha did not co-precipitate with the IL-2R beta/gamma c complex (PMID: 8568232). The IL-15-IL-15Ralpha complex is trans-presented to neighboring responder cells that express the IL-2beta/gamma receptor complex to initiate signaling via IL-15 (PMID: 19818367, 34956227)	The IL-2R gamma subunit is found to be defective in X-linked severe combined immunodeficiency in humans. (PMID: 8026467)	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Interleukin-2 receptor subunit beta;Cytokine receptor common subunit gamma;Interleukin-15	IL2RB;IL2RG;IL15	IL15RB;None;None
8085	IL-2Ralpha/beta/gamma receptor-IL-2 complex, high affinity	Human	Interleukin-2 receptor complex, high affinity, IL-2R-alpha/beta/gamma complex; IL2RRA-IL2RB-IL2RG complex	lymphoid cell line MOLTbeta, IL-2 stimulated	P01589;P14784;P31785;P60568	3559;3560;3561;3558	MI:0004-affinity chromatography technology;MI:0019-coimmunoprecipitation	GO:0019221;GO:0042098;GO:0006955;GO:0038110;GO:0019976;GO:0070669	cytokine-mediated signaling pathway;T cell proliferation;immune response;interleukin-2-mediated signaling pathway;interleukin-2 binding;response to interleukin-2	36.25.16	immune response	1631559	The association of the IL2Rgamma chain with the IL2Rbeta chain is necessary for IL-2 binding. (PMID: 1631559)	Mutations in IL2Ramma result in X-linked severe combined immunodeficiency diseases. (PMID: 16293754)	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Interleukin-2 receptor subunit alpha;Interleukin-2 receptor subunit beta;Cytokine receptor common subunit gamma;Interleukin-2	IL2RA;IL2RB;IL2RG;IL2	None;IL15RB;None;None
8086	IL-2Rbeta/gamma receptor-IL-2 complex, intermediate affinity	Human	Interleukin-2 receptor complex, intermediate affinity; IL-2R-beta/gamma complex; IL2RB-IL2RG complex	lymphoid cell line MOLTbeta	P14784;P31785;P60568	3560;3561;3558	MI:0019-coimmunoprecipitation	GO:0019221;GO:0006955;GO:0019976;GO:0038110;GO:0042098	cytokine-mediated signaling pathway;immune response;interleukin-2 binding;interleukin-2-mediated signaling pathway;T cell proliferation	36.25.16	immune response	1631559	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Interleukin-2 receptor subunit beta;Cytokine receptor common subunit gamma;Interleukin-2	IL2RB;IL2RG;IL2	IL15RB;None;None
8087	FXN42-ISD11-ISCU-NFS1 complex	Human	Iron-sulfur cluster assembly complex	None	Q16595;Q9H1K1;Q9HD34;Q9Y697	2395;23479;57128;9054	MI:0040-electron microscopy	GO:0016226;GO:0005739	iron-sulfur cluster assembly;mitochondrion	70.16	mitochondrion	0	None	None	This complex consists of a central roughly cubic [FXN]24-[ISCU]24 sub-complex with one symmetric ISCU trimer bound on top of one symmetric FXN trimer at each of its eight vertices.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Frataxin, mitochondrial;Iron-sulfur cluster assembly enzyme ISCU, mitochondrial;LYR motif-containing protein 4;Cysteine desulfurase, mitochondrial	FXN;ISCU;LYRM4;NFS1	FRDA X25;NIFUN;C6orf149 ISD11;NIFS
8090	IL-3Ralpha/beta receptor-IL-3 complex	Human	Interleukin-3 receptor-IL-3 complex; CSF2RB-IL3RA complex, IL-3 stimulated; IL-3 alpha/beta receptor, IL-3 stimulated	CML cell line-IL-3-stimulated; UT7 cell line, IL-3-stimulated	P08700;P26951;P32927	3562;3563;1439	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0019221;GO:0006955;GO:0038156;GO:0036015	cytokine-mediated signaling pathway;immune response;interleukin-3-mediated signaling pathway;response to interleukin-3	36.25.16	immune response	8649415	The IL-3Ralpha chain and IL-3Rbeta chain only undergo dimerization following stimulation with IL-3. IL-3 could also be coimmunoprecipitated with anti-IL-3Ralpha or anti-IL3Rbeta, but it was not covalently attached to the receptor. (PMID: 8649415)	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Interleukin-3;Interleukin-3 receptor subunit alpha;Cytokine receptor common subunit beta	IL3;IL3RA;CSF2RB	None;IL3R;IL3RB, IL5RB
8091	IL-5Ralpha/IL-3Rbeta receptor-IL-5 complex, high affinity	Human	IL-5 receptor complex, high-affinity; CSF2RB-IL5RA-IL-5 complex; IL-5-IL5RA-IL5RB complex, high affinity	eosinophilic HL-60 cells	P05113;P32927;Q01344	3567;1439;3568	MI:0030-cross-linking study	GO:0019221;GO:0030222;GO:0006955;GO:0038043	cytokine-mediated signaling pathway;eosinophil differentiation;immune response;interleukin-5-mediated signaling pathway	36.25.16	immune response	1833065	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Interleukin-5;Cytokine receptor common subunit beta;Interleukin-5 receptor subunit alpha	IL5;CSF2RB;IL5RA	None;IL3RB, IL5RB;IL5R
8092	IL-20Ralpha/beta receptor-IL-20 complex	Human	Interleukin-20Ralpha/beta receptor-interleukin-20 complex; IL20-IL20Ralpha/beta complex; IL20-IL20RA-IL20RB complex; IL20-IL20R1-IL20R2 ternary complex; IL-20-IL-20Ralpha/beta complex; IL-20-IL-20R1-IL-20R2 complex	in vitro	Q6UXL0;Q9NYY1;Q9UHF4	53833;50604;53832	MI:0071-molecular sieving;MI:0114-x-ray crystallography	GO:0019221;GO:0006955	cytokine-mediated signaling pathway;immune response	36.25.16	immune response	22232181	None	Dysregulated IL-20 signaling has been shown to contribute to the pathogenesis of human psoriasis. IL-20 is upregulated in samples derived from synovial membranes of rheumatoid arthritis patients.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Interleukin-20 receptor subunit beta;Interleukin-20;Interleukin-20 receptor subunit alpha	IL20RB;IL20;IL20RA	DIRS1;ZCYTO10;None
8094	IL-18Ralpha receptor-IL-18 complex	Human	Interleukin-18Ralpha receptor-interleukin-18 complex; IL18-IL18R1 complex	in vitro (Sf9 cells)	Q13478;Q14116	8809;3606	MI:0071-molecular sieving;MI:0114-x-ray crystallography	GO:0019221;GO:0035655;GO:0002250;GO:0045087;GO:0050727	cytokine-mediated signaling pathway;interleukin-18-mediated signaling pathway;adaptive immune response;innate immune response;regulation of inflammatory response	36.25.16.01	innate immune response (invertebrates and vertebrates)	25286938	None	IL-18 contributes to the pathogenesis of autoimmune/autoinflammatory and allergic diseases.	None	Homo sapiens (Human);Homo sapiens (Human)	Interleukin-18 receptor 1;Interleukin-18	IL18R1;IL18	IL1RRP;IGIF IL1F4
8095	IL-18 receptor-IL-18 complex	Human	Interleukin-18 alpha/beta receptor-interleukin-18 complex; IL-18-IL-18Ralpha-IL-18Rbeta complex; IL18-IL18R1-IL18RAP complex	in vitro (Sf9 cells)	O95256;Q13478;Q14116	8807;8809;3606	MI:0071-molecular sieving;MI:0114-x-ray crystallography	GO:0019221;GO:0035655;GO:0045087;GO:0002250;GO:0050727	cytokine-mediated signaling pathway;interleukin-18-mediated signaling pathway;innate immune response;adaptive immune response;regulation of inflammatory response	36.25.16.01	innate immune response (invertebrates and vertebrates)	25286938	None	IL-18 contributes to the pathogenesis of autoimmune/autoinflammatory and allergic diseases.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Interleukin-18 receptor accessory protein;Interleukin-18 receptor 1;Interleukin-18	IL18RAP;IL18R1;IL18	IL1R7;IL1RRP;IGIF IL1F4
8097	Mt-MMP-1-TIMP-2 complex	Human	MMP14-TIMP2 complex	CHO1 cells	P16035;P50281	7077;4323	MI:0071-molecular sieving	GO:0030198	extracellular matrix organization	42.27.01	extracellular matrix	8665498	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Metalloproteinase inhibitor 2;Matrix metalloproteinase-14	TIMP2;MMP14	None;None
8098	MT-MMP-1-TIMP2-proMMP-2 complex	Human	MMP2-MMP14-TIMP2 complex	COS1 cells	P08253;P16035;P50281	4313;7077;4323	MI:0071-molecular sieving	GO:0030198	extracellular matrix organization	42.27.01	extracellular matrix	8665498	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	72 kDa type IV collagenase;Metalloproteinase inhibitor 2;Matrix metalloproteinase-14	MMP2;TIMP2;MMP14	CLG4A;None;None
8099	NIPBL-RAD21-SMC1A complex	Human	None	Primary dermal fibroblasts from individuals with Cornelia de Lange syndrome 1	O60216;Q14683;Q6KC79	5885;8243;25836	MI:0019-coimmunoprecipitation	GO:0000785	chromatin	None	None	34315879	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Double-strand-break repair protein rad21 homolog;Structural maintenance of chromosomes protein 1A;Nipped-B-like protein	RAD21;SMC1A;NIPBL	HR21 KIAA0078 NXP1 SCC1;DXS423E KIAA0178 SB1.8 SMC1 SMC1L1;IDN3,SCC2
8100	EMC2-EMC8-WNK1 complex	Human	None	HeLa cells	O43402;Q15006;Q9H4A3	10328;9694;65125	MI:0091-chromatography technology	GO:0007029	endoplasmic reticulum organization	42.07	endoplasmic reticulum	33964204	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	ER membrane protein complex subunit 8;ER membrane protein complex subunit 2;Serine/threonine-protein kinase WNK1	EMC8;EMC2;WNK1	C16orf2 C16orf4 COX4AL COX4NB FAM158B NOC4;KIAA0103,TTC35;HSN2 KDP KIAA0344 PRKWNK1
8101	EMC2-EMC5-EMC8 complex	Human	None	HeLa cells	O43402;Q15006;Q8N4V1	10328;9694;93380	MI:0091-chromatography technology	GO:0007029	endoplasmic reticulum organization	42.07	endoplasmic reticulum	33964204	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	ER membrane protein complex subunit 8;ER membrane protein complex subunit 2;ER membrane protein complex subunit 5	EMC8;EMC2;MMGT1	C16orf2 C16orf4 COX4AL COX4NB FAM158B NOC4;KIAA0103,TTC35;EMC5,TMEM32
8102	IL-20Ralpha/beta receptor-IL-19 complex	Human	Interleukin-20Ralpha/beta receptor-interleukin-19 complex; IL19-IL20Ralpha/beta complex; IL19-IL20R1-IL20R2 complex; IL19-IL20RA-IL20RB complex	in vitro (Drosophila S2 cells)	Q6UXL0;Q9UHD0;Q9UHF4	53833;29949;53832	MI:0071-molecular sieving	GO:0019221;GO:0006955	cytokine-mediated signaling pathway;immune response	36.25.16	immune response	14580208	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Interleukin-20 receptor subunit beta;Interleukin-19;Interleukin-20 receptor subunit alpha	IL20RB;IL19;IL20RA	DIRS1;ZMDA1;None
8103	CAK-ERCC2 subcomplex	Human	CCNH-CDK7-ERCC2-MNAT1 complex; CAK-XPD subcomplex	HeLa cells	P18074;P50613;P51946;P51948	2068;1022;902;4331	MI:0019-coimmunoprecipitation;MI:0071-molecular sieving	GO:0006351;GO:0005634;GO:0007049	DNA-templated transcription;nucleus;cell cycle	11;70.10;10.03	TRANSCRIPTION;nucleus;cell cycle	9130708	The CAK complex is part of the transcription factor complex TFIIH.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	General transcription and DNA repair factor IIH helicase subunit XPD;Cyclin-dependent kinase 7;Cyclin-H;CDK-activating kinase assembly factor MAT1	ERCC2;CDK7;CCNH;MNAT1	XPD XPDC;CAK CAK1 CDKN7 MO15 STK1;None;CAP35 MAT1 RNF66
8104	TFIIH transcription factor subcomplex, cdk7-specific	Human	None	HeLa cells	P18074;P19447;P32780;Q13888;Q13889;Q92759	2068;2071;2965;2966;2967;2968	MI:0019-coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0006355;GO:0005634	regulation of DNA-templated transcription;nucleus	11.02.03.04;70.10	transcriptional control;nucleus	9130708	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	General transcription and DNA repair factor IIH helicase subunit XPD;General transcription and DNA repair factor IIH helicase subunit XPB;General transcription factor IIH subunit 1;General transcription factor IIH subunit 2;General transcription factor IIH subunit 3;General transcription factor IIH subunit 4	ERCC2;ERCC3;GTF2H1;GTF2H2;GTF2H3;GTF2H4	XPD XPDC;XPB XPBC;BTF2;BTF2P44;None;None
8105	TFIIH transcription factor subcomplex, p63-specific	Human	None	HeLa cells	P18074;P19447;P50613;P51946;P51948	2068;2071;1022;902;4331	MI:0019-coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0006351;GO:0005634	DNA-templated transcription;nucleus	11;70.10	TRANSCRIPTION;nucleus	9130708	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	General transcription and DNA repair factor IIH helicase subunit XPD;General transcription and DNA repair factor IIH helicase subunit XPB;Cyclin-dependent kinase 7;Cyclin-H;CDK-activating kinase assembly factor MAT1	ERCC2;ERCC3;CDK7;CCNH;MNAT1	XPD XPDC;XPB XPBC;CAK CAK1 CDKN7 MO15 STK1;None;CAP35 MAT1 RNF66
8107	VTN-TAT complex	Human	Vitronectin-thrombin-antithrombin III complex; F2-SERPINC1-VTN complex	plasma, fibrinogen-deficient	P00734;P01008;P04004	2147;462;7448	MI:0071-molecular sieving	GO:0007596	blood coagulation	36.25.16.09	blood coagulation	7678252	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Prothrombin;Antithrombin-III;Vitronectin	F2;SERPINC1;VTN	None;AT3;None
8111	IGF1-IGFBP5 complex	Human	None	serum	P05019;P24593	3479;3488	MI:0004-affinity chromatography technology;MI:0019-coimmunoprecipitation	GO:0008286	insulin receptor signaling pathway	30.05.01.12.05	insulin receptor signalling pathway	9497324	IGFBP-5 has a higher affinity for IGF-II than IGF-I.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Insulin-like growth factor I;Insulin-like growth factor-binding protein 5	IGF1;IGFBP5	IBP1;IBP5
8112	IGF1-IGFBP5-ALS complex	Human	ALS-IGF1-IGFBP5 complex; IGFALS-IGF1-IGFBP5 complex	serum	P05019;P24593;P35858	3479;3488;3483	MI:0004-affinity chromatography technology;MI:0019-coimmunoprecipitation;MI:0071-molecular sieving	GO:0008286	insulin receptor signaling pathway	30.05.01.12.05	insulin receptor signalling pathway	9497324	IGFBP-5 forms an ALS complex more potently with IGF-I than IGF-II, although IGFBP-5 has a higher affinity to IGF-II.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Insulin-like growth factor I;Insulin-like growth factor-binding protein 5;Insulin-like growth factor-binding protein complex acid labile subunit	IGF1;IGFBP5;IGFALS	IBP1;IBP5;ALS
8113	IGF2-IGFBP5 complex	Human	None	serum	P01344;P24593	3481;3488	MI:0004-affinity chromatography technology;MI:0019-coimmunoprecipitation;MI:0071-molecular sieving	GO:0008286	insulin receptor signaling pathway	30.05.01.12.05	insulin receptor signalling pathway	9497324	IGFBP-5 has a higher affinity for IGF-II than IGF-I.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Insulin-like growth factor II;Insulin-like growth factor-binding protein 5	IGF2;IGFBP5	None;IBP5
8114	IGF2-IGFBP5-ALS complex	Human	ALS-IGF2-IGFBP5 complex; IGFALS-IGF2-IGFBP5 complex	serum	P01344;P24593;P35858	3481;3488;3483	MI:0004-affinity chromatography technology;MI:0019-coimmunoprecipitation;MI:0071-molecular sieving	GO:0008286	insulin receptor signaling pathway	30.05.01.12.05	insulin receptor signalling pathway	9497324	IGFBP-5 forms an ALS complex more potently with IGF-I than IGF-II, although IGFBP-5 has a higher affinity to IGF-II.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Insulin-like growth factor II;Insulin-like growth factor-binding protein 5;Insulin-like growth factor-binding protein complex acid labile subunit	IGF2;IGFBP5;IGFALS	None;IBP5;ALS
8115	IL6R/IL6ST receptor-IL6 complex	Human	IL-6R-IL-6-gp130 complex	myeloma cell line U266	P05231;P08887;P40189	3569;3570;3572	MI:0019-coimmunoprecipitation;MI:0030-cross-linking study	GO:0019221;GO:0006955;GO:0070102;GO:0006953;GO:0031347	cytokine-mediated signaling pathway;immune response;interleukin-6-mediated signaling pathway;acute-phase response;regulation of defense response	36.25.16;36.25.16.01.07	immune response;acute phase response (C-reactive protein)	2788034	The IL-6-IL-6-R complex can interact with the non-ligand-binding membrane glycoprotein gp130 (IL6ST) extracellularly and can provide the IL-6 signal.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Interleukin-6;Interleukin-6 receptor subunit alpha;Interleukin-6 receptor subunit beta	IL6;IL6R;IL6ST	IFNB2;None;None
8117	PCID2-ENY2-GANP-SEM1-CETN2 complex	Human	None	None	O60318;P41208;P60896;Q5JVF3;Q9NPA8	8888;1069;7979;55795;56943	MI:0114-x-ray crystallography	GO:0051028	mRNA transport	None	None	22307388	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Germinal-center associated nuclear protein;Centrin-2;26S proteasome complex subunit SEM1;PCI domain-containing protein 2;Transcription and mRNA export factor ENY2	MCM3AP;CETN2;SEM1;PCID2;ENY2	GANP KIAA0572 MAP80;CALT CEN2;C7orf76 DSS1 SHFDG1 SHFM1;None;None
8118	PCID2-ENY2-GANP-SEM1-CETN3 complex	Human	None	None	O15182;O60318;P60896;Q5JVF3;Q9NPA8	1070;8888;7979;55795;56943	MI:0114-x-ray crystallography	GO:0051018	protein kinase A binding	None	None	22307388	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Centrin-3;Germinal-center associated nuclear protein;26S proteasome complex subunit SEM1;PCI domain-containing protein 2;Transcription and mRNA export factor ENY2	CETN3;MCM3AP;SEM1;PCID2;ENY2	CEN3;GANP KIAA0572 MAP80;C7orf76 DSS1 SHFDG1 SHFM1;None;None
8121	PCGF1-RING1A complex	Human	PCGF1-RING1 complex	None	Q06587;Q9BSM1	6015;84759	MI:0019-coimmunoprecipitation;MI:0091-chromatography technology	GO:0016567	protein ubiquitination	14.07.05	modification by ubiquitination, deubiquitination	26151332	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase RING1;Polycomb group RING finger protein 1	RING1;PCGF1	RNF1;NSPC1 RNF68
8122	PCGF1-RING1B complex	Human	PCGF1-RNF2 complex	None	Q99496;Q9BSM1	6045;84759	MI:0019-coimmunoprecipitation;MI:0091-chromatography technology	GO:0016567	protein ubiquitination	14.07.05	modification by ubiquitination, deubiquitination	26151332	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase RING2;Polycomb group RING finger protein 1	RNF2;PCGF1	BAP1 DING HIPI3 RING1B;NSPC1 RNF68
8123	PCGF2-RING1A complex	Human	PCGF2-RING1 complex	None	P35227;Q06587	7703;6015	MI:0019-coimmunoprecipitation;MI:0091-chromatography technology	GO:0016567	protein ubiquitination	14.07.05	modification by ubiquitination, deubiquitination	26151332	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Polycomb group RING finger protein 2;E3 ubiquitin-protein ligase RING1	PCGF2;RING1	MEL18 RNF110 ZNF144;RNF1
8124	PCGF2-RING1B complex	Human	PCGF2-RNF2 complex	None	P35227;Q99496	7703;6045	MI:0019-coimmunoprecipitation;MI:0091-chromatography technology	GO:0016567	protein ubiquitination	14.07.05	modification by ubiquitination, deubiquitination	26151332	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Polycomb group RING finger protein 2;E3 ubiquitin-protein ligase RING2	PCGF2;RNF2	MEL18 RNF110 ZNF144;BAP1 DING HIPI3 RING1B
8125	PCGF3-RING1A complex	Human	PCGF3-RING1 complex	None	Q06587;Q3KNV8	6015;10336	MI:0019-coimmunoprecipitation;MI:0091-chromatography technology	GO:0016567	protein ubiquitination	14.07.05	modification by ubiquitination, deubiquitination	26151332	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase RING1;Polycomb group RING finger protein 3	RING1;PCGF3	RNF1;RNF3,RNF3A
8126	PCGF3-RING1B complex	Human	PCGF3-RNF2 complex	None	Q3KNV8;Q99496	10336;6045	MI:0019-coimmunoprecipitation;MI:0091-chromatography technology	GO:0016567	protein ubiquitination	14.07.05	modification by ubiquitination, deubiquitination	26151332	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Polycomb group RING finger protein 3;E3 ubiquitin-protein ligase RING2	PCGF3;RNF2	RNF3,RNF3A;BAP1 DING HIPI3 RING1B
8127	PCGF4-RING1A complex	Human	BMI1-RING1 complex	None	P35226;Q06587	648;6015	MI:0019-coimmunoprecipitation;MI:0091-chromatography technology	GO:0016567	protein ubiquitination	14.07.05	modification by ubiquitination, deubiquitination	26151332	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Polycomb complex protein BMI-1;E3 ubiquitin-protein ligase RING1	BMI1;RING1	PCGF4 RNF51;RNF1
8128	PCGF4-RING1B complex	Human	BMI1-RNF2 complex	None	P35226;Q99496	648;6045	MI:0019-coimmunoprecipitation;MI:0091-chromatography technology	GO:0016567	protein ubiquitination	14.07.05	modification by ubiquitination, deubiquitination	26151332	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Polycomb complex protein BMI-1;E3 ubiquitin-protein ligase RING2	BMI1;RNF2	PCGF4 RNF51;BAP1 DING HIPI3 RING1B
8129	PCGF5-RING1A complex	Human	PCGF5-RING1 complex	None	Q06587;Q86SE9	6015;84333	MI:0019-coimmunoprecipitation;MI:0091-chromatography technology	GO:0016567	protein ubiquitination	14.07.05	modification by ubiquitination, deubiquitination	26151332	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase RING1;Polycomb group RING finger protein 5	RING1;PCGF5	RNF1;RNF159
8130	PCGF5-RING1B complex	Human	PCGF5-RNF2 complex	None	Q86SE9;Q99496	84333;6045	MI:0019-coimmunoprecipitation;MI:0091-chromatography technology	GO:0016567	protein ubiquitination	14.07.05	modification by ubiquitination, deubiquitination	26151332	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Polycomb group RING finger protein 5;E3 ubiquitin-protein ligase RING2	PCGF5;RNF2	RNF159;BAP1 DING HIPI3 RING1B
8131	PCGF6-RING1A complex	Human	PCGF6-RING1 complex	None	Q06587;Q9BYE7	6015;84108	MI:0019-coimmunoprecipitation;MI:0091-chromatography technology	GO:0016567	protein ubiquitination	14.07.05	modification by ubiquitination, deubiquitination	26151332	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase RING1;Polycomb group RING finger protein 6	RING1;PCGF6	RNF1;MBLR RNF134
8132	PCGF6-RING1B complex	Human	PCGF6-RNF2 complex	None	Q99496;Q9BYE7	6045;84108	MI:0019-coimmunoprecipitation;MI:0091-chromatography technology	GO:0016567	protein ubiquitination	14.07.05	modification by ubiquitination, deubiquitination	26151332	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase RING2;Polycomb group RING finger protein 6	RNF2;PCGF6	BAP1 DING HIPI3 RING1B;MBLR RNF134
8133	PDCD4-RICTOR complex	Human	None	HK2 proximal tubular epithelial cells	Q53EL6;Q6R327	27250;253260	MI:0019-coimmunoprecipitation	GO:1903939	regulation of TORC2 signaling	None	None	25016284	PDCD4 forms a complex with rictor, an exclusive component of mTORC2.	This complex formation is reduced in renal cancer cells due to increased miR-21 expression resulting in enhanced phosphorylation of Akt.	None	Homo sapiens (Human);Homo sapiens (Human)	Programmed cell death protein 4;Rapamycin-insensitive companion of mTOR	PDCD4;RICTOR	H731;KIAA1999
8134	MVB12B-PDCD6-PDCD6IP-TSG101-VPS28-VPS37A complex	Human	ALIX-ALG-2-ESCRT-I(VPS37A) complex	HEK293T cells	O75340;Q8NEZ2;Q8WUM4;Q99816;Q9H7P6;Q9UK41	10016;137492;10015;7251;89853;51160	MI:0096-pull down;MI:0400-affinity technology	GO:0015031	protein transport	20.01.10	protein transport	23924735	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Programmed cell death protein 6;Vacuolar protein sorting-associated protein 37A;Programmed cell death 6-interacting protein;Tumor susceptibility gene 101 protein;Multivesicular body subunit 12B;Vacuolar protein sorting-associated protein 28 homolog	PDCD6;VPS37A;PDCD6IP;TSG101;MVB12B;VPS28	ALG2;HCRP1;AIP1 ALIX KIAA1375;None;C9orf28 FAM125B;None
8135	TPA-PLG-TSP complex	Human	PLAT-PLG-THBS1 complex	None	P00747;P00750;P07996	5340;5327;7057	MI:0004-affinity chromatography technology	GO:0031639	plasminogen activation	None	None	3160707	None	None	Since the authors did not specify TSP, we used isoform THBS1.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Plasminogen;Tissue-type plasminogen activator;Thrombospondin-1	PLG;PLAT;THBS1	None;None;TSP TSP1
8136	TPA-PLG-HRGP complex	Human	HRG-PLAT-PLG complex	None	P00747;P00750;P04196	5340;5327;3273	MI:0004-affinity chromatography technology	GO:0031639	plasminogen activation	None	None	3160707	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Plasminogen;Tissue-type plasminogen activator;Histidine-rich glycoprotein	PLG;PLAT;HRG	None;None;None
8137	PLG-TSP complex	Human	None	platelet	P00747;P07996	5340;7057	MI:0004-affinity chromatography technology;MI:0411-enzyme linked immunosorbent assay	GO:0031639;GO:0072378	plasminogen activation;blood coagulation, fibrin clot formation	None	None	6438154	None	None	Since the authors did not specify TSP, we used isoform THBS1.	Homo sapiens (Human);Homo sapiens (Human)	Plasminogen;Thrombospondin-1	PLG;THBS1	None;TSP TSP1
8138	HRG-PLG complex	Human	None	plasma	P00747;P04196	5340;3273	MI:0004-affinity chromatography technology	GO:0042730	fibrinolysis	None	None	6448849	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Plasminogen;Histidine-rich glycoprotein	PLG;HRG	None;None
8140	CNTFRalpha-sorLA complex	Human	CNTFR-SORL1 complex	HEK293 cell	P26992;Q92673	1271;6653	MI:0030-cross-linking study	GO:0019221	cytokine-mediated signaling pathway	None	None	26858303	None	Mutations in CLC or CLF-1 cause a series of similar manifestations known as Sohar-Crisponi or cold-induced sweating syndrome.	None	Homo sapiens (Human);Homo sapiens (Human)	Ciliary neurotrophic factor receptor subunit alpha;Sortilin-related receptor	CNTFR;SORL1	None;C11orf32
8142	CLC-CLF-CNTFR complex	Human	None	IMR 32 cells	O75462;P26992;Q9UBD9	9244;1271;23529	MI:0019-coimmunoprecipitation	GO:0019221;GO:0048666	cytokine-mediated signaling pathway;neuron development	None	None	10966616	None	Mutations in CLC or CLF1 cause a series of similar manifestations known as Sohar-Crisponi or cold-induced sweating syndrome. (PMID: 26858303)	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cytokine receptor-like factor 1;Ciliary neurotrophic factor receptor subunit alpha;Cardiotrophin-like cytokine factor 1	CRLF1;CNTFR;CLCF1	None;None;BSF3 CLC NNT1
8143	Interleukin-27	Human	IL-27; IL-27 cytokine; IL27-EBI3 complex	HEK293T cells	Q14213;Q8NEV9	10148;246778	MI:0019-coimmunoprecipitation	GO:0019221;GO:0042110;GO:0035397;GO:0006955;GO:0070106	cytokine-mediated signaling pathway;T cell activation;helper T cell enhancement of adaptive immune response;immune response;interleukin-27-mediated signaling pathway	36.25.16	immune response	12121660	IL-27 is an early product of activated antigen-presenting cells and drives rapid clonal expansion of naive but not memory CD4(+) T cells. (PMID: 12121660)	None	None	Homo sapiens (Human);Homo sapiens (Human)	Interleukin-27 subunit beta;Interleukin-27 subunit alpha	EBI3;IL27	IL27B;IL27A,IL30
8144	MAP2K1-NEK10-RAF1 complex	Human	MEK autoactivation complex	HEK293 cells	P04049;Q02750;Q6ZWH5	5894;5604;152110	MI:0019-coimmunoprecipitation	GO:0009411	response to UV	None	None	20956560	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	RAF proto-oncogene serine/threonine-protein kinase;Dual specificity mitogen-activated protein kinase kinase 1;Serine/threonine-protein kinase Nek10	RAF1;MAP2K1;NEK10	RAF;MEK1 PRKMK1;None
8145	p28-CLF complex	Human	IL27A-CLF complex; IL-27(p28)-CLF complex; CRLF1-IL27 complex	HEK-293 cells	O75462;Q8NEV9	9244;246778	MI:0019-coimmunoprecipitation	GO:0030101;GO:0019221;GO:0097696;GO:0006955	natural killer cell activation;cytokine-mediated signaling pathway;receptor signaling pathway via STAT;immune response	36.25.16	immune response	19933857	The p28-CLF complex is produced by dendritic cells and induces STAT1 and STAT3 phosphorylation in CD4 and CD8 T cells and cytokine production in CD4 T cells.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cytokine receptor-like factor 1;Interleukin-27 subunit alpha	CRLF1;IL27	None;IL27A,IL30
8147	CDC25C-cyclinA-CDK2 complex	Human	CCNA2-CDC25C-CDK2 complex	in vitro	P20248;P24941;P30307	890;1017;995	MI:0071-molecular sieving;MI:0091-chromatography technology	GO:0007049	cell cycle	10.03	cell cycle	9973565	Cdc25C forms stable ternary complexes, first through a high affinity interaction with a cyclin, which may then help target cdc25C towards a cdk.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cyclin-A2;Cyclin-dependent kinase 2;M-phase inducer phosphatase 3	CCNA2;CDK2;CDC25C	CCN1 CCNA;CDKN2;None
8148	GMNN-MCIDAS complex	Human	None	MCF-7 cells	D6RGH6;O75496	345643;51053	MI:0019-coimmunoprecipitation	GO:0007346	regulation of mitotic cell cycle	None	None	21543332	Sequence analysis suggested that Idas could associate with Geminin and/or Cdt1.  The results suggest that Idas and Idas-Geminin complexes do not interact with Cdt1 in cells (PMID:21543332).	None	None	Homo sapiens (Human);Homo sapiens (Human)	Multicilin;Geminin	MCIDAS;GMNN	IDAS,MCI,MCIN;None
8151	Repairosome complex, XPA-specific	Human	Nucleotide-excision repair complex, XPA-specific; NER complex	HeLa cells	P07992;P12004;P15927;P18074;P18858;P19447;P23025;P28715;P32780;P35251	2067;5111;6118;2068;3978;2071;7507;2073;2965;5981	MI:0004-affinity chromatography technology	GO:0006289;GO:0006974	nucleotide-excision repair;cellular response to DNA damage stimulus	32.01.09	DNA damage response	9092621	The repairosome complex is pre-assembled in the absence of damaged DNA.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA excision repair protein ERCC-1;Proliferating cell nuclear antigen;Replication protein A 32 kDa subunit;General transcription and DNA repair factor IIH helicase subunit XPD;DNA ligase 1;General transcription and DNA repair factor IIH helicase subunit XPB;DNA repair protein complementing XP-A cells;DNA excision repair protein ERCC-5;General transcription factor IIH subunit 1;Replication factor C subunit 1	ERCC1;PCNA;RPA2;ERCC2;LIG1;ERCC3;XPA;ERCC5;GTF2H1;RFC1	None;None;REPA2 RPA32 RPA34;XPD XPDC;None;XPB XPBC;XPAC;ERCM2 XPG XPGC;BTF2;RFC140
8152	Repairosome sub-complex, XPA-specific	Human	Nucleotide-excision repair sub-complex, XPA-specific; NER sub-complex	HeLa cells	P12004;P23025;P27694;P28715;P32780;P35251	5111;7507;6117;2073;2965;5981	MI:0019-coimmunoprecipitation	GO:0006289;GO:0006974	nucleotide-excision repair;cellular response to DNA damage stimulus	32.01.09	DNA damage response	9092621	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Proliferating cell nuclear antigen;DNA repair protein complementing XP-A cells;Replication protein A 70 kDa DNA-binding subunit;DNA excision repair protein ERCC-5;General transcription factor IIH subunit 1;Replication factor C subunit 1	PCNA;XPA;RPA1;ERCC5;GTF2H1;RFC1	None;XPAC;REPA1 RPA70;ERCM2 XPG XPGC;BTF2;RFC140
8153	ADA-DPP4 complex	Human	None	kidney	P00813;P27487	100;1803	MI:0071-molecular sieving	GO:0004000;GO:0006154	adenosine deaminase activity;adenosine catabolic process	None	None	893413	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Adenosine deaminase;Dipeptidyl peptidase 4	ADA;DPP4	ADA1;ADCP2 CD26
8154	Glycoprotein Ib-IX complex	Human	GPIb-IX complex; GP1BA-GP1BB-GP9 complex	platelet plasma membranes	P07359;P13224;P14770	2811;2812;2815	MI:0004-affinity chromatography technology;MI:0071-molecular sieving	GO:0030168	platelet activation	None	None	17008541	Platelet glycoprotein Ib (GP Ib) is a major integral membrane protein that has been identified as the platelet-binding site mediating the factor VIII/von Willebrand-factor-dependent adhesion of platelets to vascular subendothelium.	Deranged GPIb-IX complex leads to pathological thrombosis. (PMID: 8180344)	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Platelet glycoprotein Ib alpha chain;Platelet glycoprotein Ib beta chain;Platelet glycoprotein IX	GP1BA;GP1BB;GP9	None;None;None
8155	Glycoprotein Ib-IX-V complex	Human	GPIb-IX-V complex; GP1BA-GP1BB-GP9-GP5 complex	platelets	P07359;P13224;P14770;P40197	2811;2812;2815;2814	MI:0019-coimmunoprecipitation	GO:0030168	platelet activation	None	None	1730602	None	GPV and GPIb-IX are deficient in the Bernard-Soulier syndrome, a bleeding disorder characterized by giant platelets and defective interaction with von Willebrand factor.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Platelet glycoprotein Ib alpha chain;Platelet glycoprotein Ib beta chain;Platelet glycoprotein IX;Platelet glycoprotein V	GP1BA;GP1BB;GP9;GP5	None;None;None;None
8156	RAN-RCC1 complex	Human	None	HeLa cells	P18754;P62826	1104;5901	MI:0004-affinity chromatography technology;MI:0071-molecular sieving	GO:0000278	mitotic cell cycle	10.03.01.01	mitotic cell cycle	2236072	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Regulator of chromosome condensation;GTP-binding nuclear protein Ran	RCC1;RAN	CHC1;ARA24
8157	CXCR4-CXCL12 complex	Human	CXCR4-SDF1A complex	None	P48061;P61073	6387;7852	MI:0226-ion exchange chromatography	GO:0070098	chemokine-mediated signaling pathway	None	None	16962791	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Stromal cell-derived factor 1;C-X-C chemokine receptor type 4	CXCL12;CXCR4	SDF1,SDF1A,SDF1B;None
8158	HHR23B-XPC complex	Human	RAD23B-XPC complex	HeLa cells	P54727;Q01831	5887;7508	MI:0004-affinity chromatography technology;MI:0071-molecular sieving	GO:0006289;GO:0006974	nucleotide-excision repair;cellular response to DNA damage stimulus	32.01.09	DNA damage response	8692695	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	UV excision repair protein RAD23 homolog B;DNA repair protein complementing XP-C cells	RAD23B;XPC	None;XPCC
8159	Aposome complex	Human	None	apoptotic THP.1 cells or THP.1 cells, dATP activated	O14727;P42574;P55210;P55211	317;836;840;842	MI:0027-cosedimentation;MI:0071-molecular sieving	GO:0006915	apoptotic process	40.10.02	apoptosis (type I programmed cell death)	10428850	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Apoptotic protease-activating factor 1;Caspase-3;Caspase-7;Caspase-9	APAF1;CASP3;CASP7;CASP9	KIAA0413;CPP32;MCH3;MCH6
8160	Microaposome complex	Human	None	apoptotic THP.1 cells or THP.1 cells, dATP activated	P42574;P55210	836;840	MI:0027-cosedimentation;MI:0071-molecular sieving	GO:0006915	apoptotic process	40.10.02	apoptosis (type I programmed cell death)	10428850	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Caspase-3;Caspase-7	CASP3;CASP7	CPP32;MCH3
8161	Procaspase 7-APAF1 complex	Human	CASP7-APAF1 complex	THP.1 cells, not-activated	O14727;P55210	317;840	MI:0027-cosedimentation	GO:0006915	apoptotic process	40.10.02	apoptosis (type I programmed cell death)	10428850	In cells that were not caspase activated, procaspase-7 elutes together with APAF-1 indicating that procaspase-9 regulates the activity of APAF-1 in control cells.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Apoptotic protease-activating factor 1;Caspase-7	APAF1;CASP7	KIAA0413;MCH3
8162	DNMT1-associated protein complex	Human	None	HEK 293 cells	P12004;P26358;Q13547;Q92993;Q93009;Q96T88	5111;1786;3065;10524;7874;29128	MI:0019-coimmunoprecipitation	GO:0006306;GO:0006511	DNA methylation;ubiquitin-dependent protein catabolic process	10.01.09.01;14.13.01.01	DNA methylation;proteasomal degradation (ubiquitin/proteasomal pathway)	21045206	This complex regulates DNMT1 protein stability through control of its ubiquitination.	HAUSP knockdown rendered colon cancer cells more sensitive to killing by HDAC inhibitors both in tissue culture and in tumor xenograft models. (PMID: 21045206)	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Proliferating cell nuclear antigen;DNA;Histone deacetylase 1;Histone acetyltransferase KAT5;Ubiquitin carboxyl-terminal hydrolase 7;E3 ubiquitin-protein ligase UHRF1	PCNA;DNMT1;HDAC1;KAT5;USP7;UHRF1	None;AIM CXXC9 DNMT;RPD3L1;HTATIP, TIP60;HAUSP;ICBP90 NP95 RNF106
8163	MVB12B-PDCD6-PDCD6IP-TSG101-VPS28-VPS37B complex	Human	ALIX-ALG-2-ESCRT-I(VPS37B) complex	HEK293T cells	O75340;Q8WUM4;Q99816;Q9H7P6;Q9H9H4;Q9UK41	10016;10015;7251;89853;79720;51160	MI:0096-pull down;MI:0400-affinity technology	GO:0015031	protein transport	20.01.10	protein transport	23924735	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Programmed cell death protein 6;Programmed cell death 6-interacting protein;Tumor susceptibility gene 101 protein;Multivesicular body subunit 12B;Vacuolar protein sorting-associated protein 37B;Vacuolar protein sorting-associated protein 28 homolog	PDCD6;PDCD6IP;TSG101;MVB12B;VPS37B;VPS28	ALG2;AIP1 ALIX KIAA1375;None;C9orf28 FAM125B;None;None
8164	MVB12B-PDCD6-PDCD6IP-TSG101-VPS28-VPS37C complex	Human	ALIX-ALG-2-ESCRT-I(VPS37C) complex	HEK293T cells	A5D8V6;O75340;Q8WUM4;Q99816;Q9H7P6;Q9UK41	55048;10016;10015;7251;89853;51160	MI:0096-pull down;MI:0400-affinity technology	GO:0015031	protein transport	20.01.10	protein transport	23924735	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Vacuolar protein sorting-associated protein 37C;Programmed cell death protein 6;Programmed cell death 6-interacting protein;Tumor susceptibility gene 101 protein;Multivesicular body subunit 12B;Vacuolar protein sorting-associated protein 28 homolog	VPS37C;PDCD6;PDCD6IP;TSG101;MVB12B;VPS28	PML39;ALG2;AIP1 ALIX KIAA1375;None;C9orf28 FAM125B;None
8165	MVB12B-PDCD6-PDCD6IP-TSG101-VPS28-VPS37D complex	Human	ALIX-ALG-2-ESCRT-I(VPS37D) complex	HEK293T cells	O75340;Q86XT2;Q8WUM4;Q99816;Q9H7P6;Q9UK41	10016;155382;10015;7251;89853;51160	MI:0096-pull down;MI:0400-affinity technology	GO:0015031	protein transport	20.01.10	protein transport	23924735	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Programmed cell death protein 6;Vacuolar protein sorting-associated protein 37D;Programmed cell death 6-interacting protein;Tumor susceptibility gene 101 protein;Multivesicular body subunit 12B;Vacuolar protein sorting-associated protein 28 homolog	PDCD6;VPS37D;PDCD6IP;TSG101;MVB12B;VPS28	ALG2;WBSCR24;AIP1 ALIX KIAA1375;None;C9orf28 FAM125B;None
8166	CD63-syntenin-1 complex	Human	CD63-SDCBP complex	HeLa cells	O00560;P08962	6386;967	MI:0040-electron microscopy;MI:0051-fluorescence technology	GO:0075502	endosome membrane permeabilization involved in viral entry into host cell	None	None	27578500	Electron microscopy and immunofluorescence experiments indicate that the CD63-syntenin-1complex controls delivery of internalised viral particles to multivesicular endosomes. (PMID: 27578500)	None	None	Homo sapiens (Human);Homo sapiens (Human)	Syntenin-1;CD63 antigen	SDCBP;CD63	MDA9,SYCL;MLA1 TSPAN30
8167	ZMYND10 complex, cytoplasmic	Human	None	HEK 293T cells	O75800;P11142;P57076;Q86X45;Q8NA54;Q8WXU2;Q9Y230	51364;3312;56683;23639;154865;161582;10856	MI:0019-coimmunoprecipitation;MI:0051-fluorescence technology	GO:0070286;GO:0060271;GO:0044458	axonemal dynein complex assembly;cilium assembly;motile cilium assembly	None	None	29601588	None	Mutations in CFAP298, DNAAF11, DNAAF4, and ZMYND10 cause Primary ciliary dyskinesia.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Zinc finger MYND domain-containing protein 10;Heat shock cognate 71 kDa protein;Cilia- and flagella-associated protein 298;Dynein axonemal assembly factor 11;IQ and ubiquitin-like domain-containing protein;Dynein axonemal assembly factor 4;RuvB-like 2	ZMYND10;HSPA8;CFAP298;DNAAF11;IQUB;DNAAF4;RUVBL2	BLU;HSC70 HSP73 HSPA10;C21orf48 C21orf59;LRRC6 LRTP TSLRP;None;DYX1C1,EKN1;INO80J TIP48 TIP49B
8168	STAT1-STAT3 complex	Human	None	SCCHN cells	P40763;P42224	6774;6772	MI:0019-coimmunoprecipitation	GO:0007259	receptor signaling pathway via JAK-STAT	30.01.05.01.01	JAK-STAT cascade	21207025	STAT1-STAT3 heterodimers were detected at low levels in the SCCHN cells under basal conditions, and both IL-6 and IFN-gamma treatments increased complex formation.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Signal transducer and activator of transcription 3;Signal transducer and activator of transcription 1-alpha/beta	STAT3;STAT1	APRF;None
8169	CD63-PDCD6IP-SDCBP complex	Human	ALIX-CD63-syntenin-1 complex	HeLa cells	O00560;P08962;Q8WUM4	6386;967;10015	MI:0040-electron microscopy;MI:0051-fluorescence technology	GO:0075733	intracellular transport of virus	None	None	27578500	None	CD63-syntenin-1-ALIX complex is a novel factor in the viral replication cycle regulating post-endocytosis trafficking of viruses to multivesicular endosomes. (PMID:27578500).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Syntenin-1;CD63 antigen;Programmed cell death 6-interacting protein	SDCBP;CD63;PDCD6IP	MDA9,SYCL;MLA1 TSPAN30;AIP1 ALIX KIAA1375
8170	IFNAR1-IFNAR2-TYK2 complex	Human	IFN alpha receptor-TYK2 complex; Interferon alpha receptor-TYK2 complex	HeLa S3 cells; RPMI-8402 cells	P17181;P29597;P48551	3454;7297;3455	MI:0006-anti bait coimmunoprecipitation;MI:0030-cross-linking study	GO:0060337;GO:0045087;GO:0046425;GO:0019221;GO:0051607	type I interferon signaling pathway;innate immune response;regulation of receptor signaling pathway via JAK-STAT;cytokine-mediated signaling pathway;defense response to virus	36.25.16.01	innate immune response (invertebrates and vertebrates)	8106393	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Interferon alpha/beta receptor 1;Non-receptor tyrosine-protein kinase TYK2;Interferon alpha/beta receptor 2	IFNAR1;TYK2;IFNAR2	IFNAR;None;IFNABR IFNARB
8171	STRIPAK complex	Human	None	None	O43815;P30153;P67775;Q08379;Q13033;Q5VSL9;Q9BUL8;Q9NRL3;Q9P289;Q9P2B4;Q9Y3A3	6801;5518;5515;2801;29966;85369;11235;29888;51765;55917;25843	MI:0069-mass spectrometry studies of complexes	GO:0035331;GO:1903358	negative regulation of hippo signaling;regulation of Golgi organization	None	None	21561862	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Striatin;Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform;Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform;Golgin subfamily A member 2;Striatin-3;Striatin-interacting protein 1;Programmed cell death protein 10;Striatin-4;Serine/threonine-protein kinase 26;CTTNBP2 N-terminal-like protein;MOB-like protein phocein	STRN;PPP2R1A;PPP2CA;GOLGA2;STRN3;STRIP1;PDCD10;STRN4;STK26;CTTNBP2NL;MOB4	None;None;None;None;GS2NA, SG2NA;FAM40A,KIAA1761;CCM3,TFAR15;ZIN;MASK MST4;KIAA1433;MOB3 MOBKL3 PHOCN PREI3
8173	PDCD6IP-SDCBP-SDC1 complex	Human	ALIX-syndecan\u2013syntenin complex	MCF-7 cells	O00560;P18827;Q8WUM4	6386;6382;10015	MI:0029-cosedimentation through density gradient;MI:0400-affinity technology	GO:1903551	regulation of extracellular exosome assembly	None	None	22660413	The ALIX-syndecan\u2013syntenin complex regulates the biogenesis of exosomes. (PMID:22660413)	This complex formation is reduced in renal cancer cells due to increased miR-21 expression resulting in enhanced phosphorylation of Akt. (PMID:22660413)	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Syntenin-1;Syndecan-1;Programmed cell death 6-interacting protein	SDCBP;SDC1;PDCD6IP	MDA9,SYCL;SDC;AIP1 ALIX KIAA1375
8174	IKBKG-PIDD1-RIPK1 complex	Human	PIDD-RIP1-NEMO complex	HEK293T cells	Q13546;Q9HB75;Q9Y6K9	8737;55367;8517	MI:0019-coimmunoprecipitation	GO:0043122;GO:0006977	regulation of I-kappaB kinase/NF-kappaB signaling;DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	None	None	16360037	HEK293T mock-transfected or PIDD-expressing cells were stimulated for the indicated times with 40 mM genotoxic factor etoposide. The PIDD-RIP1-NEMO complex was assembled in PIDD-expressing cells upon genotoxic stress. PIDD expression enhances genotoxic-stress-induced NF-kappaB activation through augmented sumoylation and ubiquitination of NEMO. (PMID:16360037)	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Receptor-interacting serine/threonine-protein kinase 1;p53-induced death domain-containing protein 1;NF-kappa-B essential modulator	RIPK1;PIDD1;IKBKG	RIP, RIP1;LRDD PIDD;FIP3, NEMO
8175	AKAP9-PDE4D-PRKACA complex	Human	AKAP9-PDE4D3-PKA complex	None	P17612;Q08499;Q99996	5566;5144;10142	MI:0019-coimmunoprecipitation;MI:0055-fluorescent resonance energy transfer;MI:0071-molecular sieving	GO:0043949	regulation of cAMP-mediated signaling	None	None	22908311	PKA-PDE4D3-AKAP9 complex may generate spatial compartmentalization of cyclic adenosine monophosphate (cAMP) signaling at the centrosome. (PMID:22908311)	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	cAMP-dependent protein kinase catalytic subunit alpha;cAMP-specific 3',5'-cyclic phosphodiesterase 4D;A-kinase anchor protein 9	PRKACA;PDE4D;AKAP9	PKACA;DPDE3;AKAP350 AKAP450 KIAA0803
8176	AKAP9-CAMSAP2-PDE4DIPcomplex	Human	None	HEK293T cells	Q08AD1;Q5VU43;Q99996	23271;9659;10142	MI:0019-coimmunoprecipitation	GO:1903358	regulation of Golgi organization	None	None	28814570	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Calmodulin-regulated spectrin-associated protein 2;Myomegalin;A-kinase anchor protein 9	CAMSAP2;PDE4DIP;AKAP9	CAMSAP1L1,KIAA1078;CMYA2 KIAA0454 KIAA0477 MMGL;AKAP350 AKAP450 KIAA0803
8177	MutSalpha complex	Human	MSH2-MSH6 complex	HL60, HeLa and K562 cells	P43246;P52701	4436;2956	MI:0413-electrophoretic mobility shift assay	GO:0006298;GO:0005634;GO:0006281;GO:0006974	mismatch repair;nucleus;DNA repair;cellular response to DNA damage stimulus	70.10;10.01.05.01;32.01.09	nucleus;DNA repair;DNA damage response	10403381	The MutSalpha complex complex binds to mismatched nucleotides only in the ADP-bound form. (PMID:9428522)	None	None	Homo sapiens (Human);Homo sapiens (Human)	DNA mismatch repair protein Msh2;DNA mismatch repair protein Msh6	MSH2;MSH6	None;GTBP
8178	MutSbeta complex	Human	MSH2-MSH3 complex	HL60, HeLa and K562 cells	P20585;P43246	4437;4436	MI:0413-electrophoretic mobility shift assay	GO:0006298;GO:0005634;GO:0006974;GO:0006281	mismatch repair;nucleus;cellular response to DNA damage stimulus;DNA repair	70.10;32.01.09;10.01.05.01	nucleus;DNA damage response;DNA repair	10403381	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	DNA mismatch repair protein Msh3;DNA mismatch repair protein Msh2	MSH3;MSH2	DUC1 DUG;None
8179	EMX1-GLI3-WDR11 complex	Human	None	HEK293 cells	P10071;Q04742;Q9BZH6	2737;13796;55717	MI:0019-coimmunoprecipitation	GO:0007224;GO:0060271	smoothened signaling pathway;cilium assembly	30.05.02.16	hedgehog-dependent signalling pathway	29263200	None	None	None	Homo sapiens (Human);Mus musculus (Mouse);Homo sapiens (Human)	Transcriptional activator GLI3;Homeobox protein EMX1;WD repeat-containing protein 11	GLI3;Emx1;WDR11	None;Emx-1;BRWD2 KIAA1351 WDR15
8180	GP130-JAK2-SOCS3 complex	Human	IL6ST-JAK2-SOCS3 complex	in vitro	O14543;O60674;P40189	9021;3717;3572	MI:0004-affinity chromatography technology;MI:0071-molecular sieving	GO:0070102;GO:0007259;GO:0019221;GO:0006955	interleukin-6-mediated signaling pathway;receptor signaling pathway via JAK-STAT;cytokine-mediated signaling pathway;immune response	30.01.05.01.01;36.25.16	JAK-STAT cascade;immune response	22342841	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Suppressor of cytokine signaling 3;Tyrosine-protein kinase JAK2;Interleukin-6 receptor subunit beta	SOCS3;JAK2;IL6ST	CIS3 SSI3;None;None
8181	GNB1-GNG2 complex	Human	None	None	P59768;P62873	54331;2782	MI:0004-affinity chromatography technology	GO:0007186	G protein-coupled receptor signaling pathway	30.05.02.24	G-protein coupled receptor signalling pathway	19376773	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	GNG2;GNB1	None;None
8182	GNB2-GNG3 complex	Human	None	None	P62879;P63215	2783;2785	MI:0004-affinity chromatography technology	GO:0007186	G protein-coupled receptor signaling pathway	30.05.02.24	G-protein coupled receptor signalling pathway	19376773	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	GNB2;GNG3	None;GNGT3
8183	GNB2-GNG8 complex	Human	None	None	P62879;Q9UK08	2783;94235	MI:0004-affinity chromatography technology	GO:0007186	G protein-coupled receptor signaling pathway	30.05.02.24	G-protein coupled receptor signalling pathway	19376773	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	GNB2;GNG8	None;GNG9 GNGT9
8184	GNG2-GNB4 complex	Human	None	None	P62879;Q9HAV0	2783;59345	MI:0004-affinity chromatography technology	GO:0007186	G protein-coupled receptor signaling pathway	30.05.02.24	G-protein coupled receptor signalling pathway	19376773	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2;Guanine nucleotide-binding protein subunit beta-4	GNB2;GNB4	None;None
8185	GNB5-RGS7 complex	Human	None	None	O14775;P49802	10681;6000	MI:0004-affinity chromatography technology	GO:0007186	G protein-coupled receptor signaling pathway	30.05.02.24	G-protein coupled receptor signalling pathway	19376773	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein subunit beta-5;Regulator of G-protein signaling 7	GNB5;RGS7	None;None
8186	GNB5-GNG2 complex	Human	None	None	O14775;P59768	10681;54331	MI:0004-affinity chromatography technology	GO:0007186	G protein-coupled receptor signaling pathway	30.05.02.24	G-protein coupled receptor signalling pathway	19376773	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein subunit beta-5;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	GNB5;GNG2	None;None
8187	GNG7-GNB2 complex	Human	None	None	O60262;P62879	2788;2783	MI:0004-affinity chromatography technology	GO:0007186	G protein-coupled receptor signaling pathway	30.05.02.24	G-protein coupled receptor signalling pathway	19376773	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	GNG7;GNB2	GNGT7;None
8188	GNB2-GNG12 complex	Human	None	None	P62879;Q9UBI6	2783;55970	MI:0004-affinity chromatography technology	GO:0007186	G protein-coupled receptor signaling pathway	30.05.02.24	G-protein coupled receptor signalling pathway	19376773	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2;Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	GNB2;GNG12	None;None
8189	GNG2-GNB2 complex	Human	None	None	P59768;P62879	54331;2783	MI:0004-affinity chromatography technology	GO:0007186	G protein-coupled receptor signaling pathway	30.05.02.24	G-protein coupled receptor signalling pathway	19376773	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	GNG2;GNB2	None;None
8190	GNGT2-GNB2 complex	Human	None	None	O14610;P62879	2793;2783	MI:0004-affinity chromatography technology	GO:0007186	G protein-coupled receptor signaling pathway	30.05.02.24	G-protein coupled receptor signalling pathway	19376773	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	GNGT2;GNB2	GNG8 GNG9 GNGT8;None
8191	GNB5-PDCL complex	Human	None	None	O14775;Q13371	10681;5082	MI:0004-affinity chromatography technology;MI:0019-coimmunoprecipitation	GO:0008277	regulation of G protein-coupled receptor signaling pathway	None	None	19376773	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein subunit beta-5;Phosducin-like protein	GNB5;PDCL	None;PHLOP1 PhLP1
8192	GNB1-PDCL complex	Human	None	None	P62873;Q13371	2782;5082	MI:0004-affinity chromatography technology	GO:0000827	inositol-1,3,4,5,6-pentakisphosphate kinase activity	None	None	19376773	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;Phosducin-like protein	GNB1;PDCL	None;PHLOP1 PhLP1
8193	GNB5-CCT5 complex	Human	None	None	O14775;P48643	10681;22948	MI:0004-affinity chromatography technology	None	None	None	None	19376773	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein subunit beta-5;T-complex protein 1 subunit epsilon	GNB5;CCT5	None;CCTE KIAA0098
8194	GNB1-CCT5 complex	Human	None	None	P48643;P62873	22948;2782	MI:0004-affinity chromatography technology	GO:0008277	regulation of G protein-coupled receptor signaling pathway	None	None	19376773	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	T-complex protein 1 subunit epsilon;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	CCT5;GNB1	CCTE KIAA0098;None
8195	GNB2-PDCL complex	Human	None	None	P62879;Q13371	2783;5082	MI:0004-affinity chromatography technology	GO:0008277	regulation of G protein-coupled receptor signaling pathway	None	None	19376773	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2;Phosducin-like protein	GNB2;PDCL	None;PHLOP1 PhLP1
8196	PDCL-GNB4 complex	Human	None	None	Q13371;Q9HAV0	5082;59345	MI:0004-affinity chromatography technology	GO:0008277	regulation of G protein-coupled receptor signaling pathway	None	None	19376773	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Phosducin-like protein;Guanine nucleotide-binding protein subunit beta-4	PDCL;GNB4	PHLOP1 PhLP1;None
8197	GNG4-GNB2 complex	Human	None	None	P50150;P62879	2786;2783	MI:0004-affinity chromatography technology	GO:0007186	G protein-coupled receptor signaling pathway	30.05.02.24	G-protein coupled receptor signalling pathway	19376773	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	GNG4;GNB2	GNGT4;None
8198	PDCL-GNB5-CCT complex	Human	PhLP1-Gbeta5-CCT complex	None	O14775;P48643;Q13371	10681;22948;5082	MI:0004-affinity chromatography technology	GO:1902605	heterotrimeric G-protein complex assembly	None	None	19376773	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein subunit beta-5;T-complex protein 1 subunit epsilon;Phosducin-like protein	GNB5;CCT5;PDCL	None;CCTE KIAA0098;PHLOP1 PhLP1
8199	KCNQ1-AKAP9-PDE4D3(isoform 2) complex	Human	None	CHO cells	P51787;Q08499-2;Q99996	3784;5144;10142	MI:0019-coimmunoprecipitation	GO:0005249	voltage-gated potassium channel activity	None	None	19218243	PDE4D3 isoform, like protein kinase A and protein phosphatase 1, is recruited to the IKs channel via AKAP-9 and contributes to its critical regulation by cAMP (PMID:19218243).	None	PDE4D3 (Q08499-2) is a splice variant of PDE4D.PDE4D3 isoform, but not PDE4D5 (Q08499-6) isoform, associates with AKAP-9 within IKs macromolecular complex (PMID:19218243).	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Potassium voltage-gated channel subfamily KQT member 1;Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D;A-kinase anchor protein 9	KCNQ1;PDE4D;AKAP9	KCNA8 KCNA9 KVLQT1;DPDE3;AKAP350 AKAP450 KIAA0803
8202	CCNQ-CDK10 complex	Human	None	MCF-7 cells	Q15131;Q8N1B3	8558;92002	MI:0018-two hybrid;MI:0019-coimmunoprecipitation	GO:0097472;GO:0009790	cyclin-dependent protein kinase activity;embryo development	None	None	24218572	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cyclin-dependent kinase 10;Cyclin-Q	CDK10;CCNQ	None;FAM58A
8203	KIF17-RAB23-TNPO1 complex	Human	None	hTERT-RPE1 cells	Q92973;Q9P2E2;Q9ULC3	3842;57576;51715	MI:0019-coimmunoprecipitation	GO:0042073;GO:0060271	intraciliary transport;cilium assembly	None	None	26136363	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transportin-1;Kinesin-like protein KIF17;Ras-related protein Rab-23	TNPO1;KIF17;RAB23	KPNB2 MIP1 TRN;KIAA1405,KIF3X;None
8205	PAWR-PRKCZ-SQSTM1 complex	Human	PAR4-PRKCZ-p62 complex	HeLa cells	Q05513;Q13501;Q96IZ0	5590;8878;5074	MI:0019-coimmunoprecipitation	GO:0043067;GO:0043122	regulation of programmed cell death;regulation of I-kappaB kinase/NF-kappaB signaling	40.10.02.04	regulation of apoptosis	11755531	PRKzeta (PRKCZ) promotes cell proliferation and survival likely through regulation of AP-1 and nuclear factor UB (NFUB) activation pathways, respectively. Within the PAWR-PRKCZ-SQSTM1 complex, SQSTM1 (p62) restores the PAWR(PAR-4)-mediated suppressed NFUB activity and protects cells from apoptotic death.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein kinase C zeta type;Sequestosome-1;PRKC apoptosis WT1 regulator protein	PRKCZ;SQSTM1;PAWR	PKC2;ORCA OSIL;PAR4
8206	PAXX complex	Human	DCLRE1C-KU70-KU86-LIG4-NHEJ1-PAXX-PRKDC-XRCC4 complex	HEK293 cells	P12956;P13010;P49917;P78527;Q13426;Q96SD1;Q9BUH6;Q9H9Q4	2547;7520;3981;5591;7518;64421;286257;79840	MI:0007-anti tag coimmunoprecipitation	GO:0006303;GO:0005634	double-strand break repair via nonhomologous end joining;nucleus	70.10	nucleus	25941166	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	X-ray repair cross-complementing protein 6;X-ray repair cross-complementing protein 5;DNA ligase 4;DNA-dependent protein kinase catalytic subunit;DNA repair protein XRCC4;Protein artemis;Protein PAXX;Non-homologous end-joining factor 1	XRCC6;XRCC5;LIG4;PRKDC;XRCC4;DCLRE1C;PAXX;NHEJ1	G22P1;G22P2;None;HYRC HYRC1;None;ARTEMIS ASCID SCIDA SNM1C;C9orf142 XLS;XLF
8207	ACK1-GRB2-EGFR complex	Human	None	None	P00533;P62993;Q07912	1956;2885;10188	MI:0096-pull down	None	None	None	None	19815557	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Epidermal growth factor receptor;Growth factor receptor-bound protein 2;Activated CDC42 kinase 1	EGFR;GRB2;TNK2	ERBB ERBB1 HER1;ASH;ACK1
8208	ACK1-GRB2-PPDGFR complex	Human	None	None	P16234;P62993;Q07912	5156;2885;10188	MI:0096-pull down	GO:0045859	regulation of protein kinase activity	None	None	19815557	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Platelet-derived growth factor receptor alpha;Growth factor receptor-bound protein 2;Activated CDC42 kinase 1	PDGFRA;GRB2;TNK2	PDGFR2, RHEPDGFRA;ASH;ACK1
8209	ACK1-GBR2-AXL complex	Human	None	None	P30530;P62993;Q07912	558;2885;10188	MI:0096-pull down	GO:0045859	regulation of protein kinase activity	None	None	19815557	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Tyrosine-protein kinase receptor UFO;Growth factor receptor-bound protein 2;Activated CDC42 kinase 1	AXL;GRB2;TNK2	UFO;ASH;ACK1
8210	SPDL1-USP45 complex	Human	None	KBM7 cells, U2OS cells	Q70EL2;Q96EA4	85015;54908	MI:0019-coimmunoprecipitation	GO:0016579;GO:0016477	protein deubiquitination;cell migration	14.07.05;34.05.01	modification by ubiquitination, deubiquitination;cell migration	30258100	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Ubiquitin carboxyl-terminal hydrolase 45;Protein Spindly	USP45;SPDL1	None;CCDC99
8211	ACK1-GRB2-ALK complex	Human	None	None	P62993;Q07912;Q9UM73	2885;10188;238	MI:0096-pull down	GO:0045859	regulation of protein kinase activity	None	None	19815557	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Growth factor receptor-bound protein 2;Activated CDC42 kinase 1;ALK tyrosine kinase receptor	GRB2;TNK2;ALK	ASH;ACK1;None
8212	ACK1-GRB2-LTK1 complex	Human	None	None	P29376;P62993;Q07912	4058;2885;10188	MI:0096-pull down	GO:0045859	regulation of protein kinase activity	None	None	19815557	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Leukocyte tyrosine kinase receptor;Growth factor receptor-bound protein 2;Activated CDC42 kinase 1	LTK;GRB2;TNK2	TYK1;ASH;ACK1
8213	MIG6-GRB2-EGFR complex	Human	None	None	P00533;P62993;Q9UJM3	1956;2885;54206	MI:0096-pull down	GO:0045859	regulation of protein kinase activity	None	None	19815557	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Epidermal growth factor receptor;Growth factor receptor-bound protein 2;ERBB receptor feedback inhibitor 1	EGFR;GRB2;ERRFI1	ERBB ERBB1 HER1;ASH;MIG6
8214	MIG6-GRB2-PDGFR complex	Human	None	None	P16234;P62993;Q9UJM3	5156;2885;54206	MI:0096-pull down	GO:0045859	regulation of protein kinase activity	None	None	19815557	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Platelet-derived growth factor receptor alpha;Growth factor receptor-bound protein 2;ERBB receptor feedback inhibitor 1	PDGFRA;GRB2;ERRFI1	PDGFR2, RHEPDGFRA;ASH;MIG6
8215	MIG6-GBR2-AXL complex	Human	None	None	P30530;P62993;Q9UJM3	558;2885;54206	MI:0096-pull down	GO:0045859	regulation of protein kinase activity	None	None	19815557	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Tyrosine-protein kinase receptor UFO;Growth factor receptor-bound protein 2;ERBB receptor feedback inhibitor 1	AXL;GRB2;ERRFI1	UFO;ASH;MIG6
8216	ALK-GRB2-MIG6 complex	Human	None	None	P62993;Q9UJM3;Q9UM73	2885;54206;238	MI:0096-pull down	GO:0045859	regulation of protein kinase activity	None	None	19815557	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Growth factor receptor-bound protein 2;ERBB receptor feedback inhibitor 1;ALK tyrosine kinase receptor	GRB2;ERRFI1;ALK	ASH;MIG6;None
8217	GRB2--LTK-MIG6 complex	Human	None	None	P29376;P62993;Q9UJM3	4058;2885;54206	MI:0096-pull down	GO:0045859	regulation of protein kinase activity	None	None	19815557	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Leukocyte tyrosine kinase receptor;Growth factor receptor-bound protein 2;ERBB receptor feedback inhibitor 1	LTK;GRB2;ERRFI1	TYK1;ASH;MIG6
8218	HOXA9-MEIS1-PBX1 complex	Human	None	human U-937 and KG1 myeloid leukemia cells	O00470;P31269;P40424	4211;3205;5087	MI:0007-anti tag coimmunoprecipitation;MI:0019-coimmunoprecipitation;MI:0413-electrophoretic mobility shift assay;MI:0416-fluorescence microscopy	GO:0003677;GO:0030218;GO:0005634;GO:0005737	DNA binding;erythrocyte differentiation;nucleus;cytoplasm	16.03.01;43.03.07;70.10;70.03	DNA binding;blood cell;nucleus;cytoplasm	10082572	MEIS1 is capable of forming a triple complex with HOXA9 and each of the three known PBX proteins in the absence of DNA (PMID:10082572).	Aberrant activation of the HOX, MEIS, and PBX homeodomain protein families is associated with leukemias, and retrovirally driven coexpression of HOXA9 and MEIS1 is sufficient to induce myeloid leukemia in mice (cited in PMID:10082572).	PBX1 protein is partitioned between the nucleus and cytoplasm (PMID: 10082572).	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Homeobox protein Meis1;Homeobox protein Hox-A9;Pre-B-cell leukemia transcription factor 1	MEIS1;HOXA9;PBX1	None;HOX1G;PRL
8219	CNBP-PCBP2 complex	Human	ZNF9-PCBP2 complex	RAJI lymphocytic B-cells; HEK293T cells	P62633;Q15366	7555;5094	MI:0019-coimmunoprecipitation;MI:0400-affinity technology	GO:0006417	regulation of translation	12.07	translational control	17327219	The 5'-untranslated region of the ornithine decarboxylase (ODC) mRNA contains an internal ribosomal entry site (IRES) and is transcribed by cap-independent translation. The  CNBP-PCBP2 complex stimulate translation of ODC.	None	None	Homo sapiens (Human);Homo sapiens (Human)	CCHC-type zinc finger nucleic acid binding protein;Poly(rC)-binding protein 2	CNBP;PCBP2	RNF163 ZNF9;None
8220	HOXA9-MEIS1-PBX3 complex	Human	None	human U-937 and KG1 myeloid leukemia cells	O00470;P31269;P40426	4211;3205;5090	MI:0007-anti tag coimmunoprecipitation;MI:0019-coimmunoprecipitation;MI:0413-electrophoretic mobility shift assay;MI:0416-fluorescence microscopy	GO:0003677;GO:0030218;GO:0005634	DNA binding;erythrocyte differentiation;nucleus	16.03.01;43.03.07;70.10	DNA binding;blood cell;nucleus	10082572	MEIS1 is capable of forming a triple complex with HOXA9 and each of the three known PBX proteins in the absence of DNA (PMID:10082572).	Aberrant activation of the HOX, MEIS, and PBX homeodomain protein families is associated with leukemias, and retrovirally driven coexpression of HOXA9 and MEIS1 is sufficient to induce myeloid leukemia in mice (cited in PMID:10082572).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Homeobox protein Meis1;Homeobox protein Hox-A9;Pre-B-cell leukemia transcription factor 3	MEIS1;HOXA9;PBX3	None;HOX1G;None
8221	LATS1-PCBP2-SAV1-STK3-STK4 complex	Human	LATS1-PCBP2-SAV1-MST1-MST2 complex	HEK293 cells; MCF10A cells	O95835;Q13043;Q13188;Q15366;Q9H4B6	9113;6789;6788;5094;60485	MI:0007-anti tag coimmunoprecipitation;MI:0416-fluorescence microscopy	GO:0035330	regulation of hippo signaling	None	None	27215387	PCBP2 can function as a component of the Hippo complex, enhancing signaling, suppressing activity of YAP and TAZ, and altering the growth characteristics of cells.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein kinase LATS1;Serine/threonine-protein kinase 4;Serine/threonine-protein kinase 3;Poly(rC)-binding protein 2;Protein salvador homolog 1	LATS1;STK4;STK3;PCBP2;SAV1	WARTS;KRS2, MST1;KRS1, MST2;None;WW45
8222	LATS1-PCBP1-SAV1-STK3-STK4 complex	Human	None	HEK293 cells	O95835;Q13043;Q13188;Q15365;Q9H4B6	9113;6789;6788;5093;60485	MI:0007-anti tag coimmunoprecipitation	None	None	None	None	27215387	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein kinase LATS1;Serine/threonine-protein kinase 4;Serine/threonine-protein kinase 3;Poly(rC)-binding protein 1;Protein salvador homolog 1	LATS1;STK4;STK3;PCBP1;SAV1	WARTS;KRS2, MST1;KRS1, MST2;None;WW45
8223	RIL-TRIP6-PTP-BL complex	Human	PDLIM4-TRIP6-PTPN13 complex	None	P50479;Q12923;Q15654	8572;5783;7205	MI:0051-fluorescence technology	GO:0032956	regulation of actin cytoskeleton organization	None	None	10826496	PTP-BL, RIL and TRIP6 may function as components of multi-protein complexes at actin-based sub-cellular structures. (PMID: 10826496)	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	PDZ and LIM domain protein 4;Tyrosine-protein phosphatase non-receptor type 13;Thyroid receptor-interacting protein 6	PDLIM4;PTPN13;TRIP6	RIL;PNP1 PTP1E PTPL1;OIP1
8224	PRKCD-PDPK1-PRG2 complex	Human	None	Human embryonic kidney (293) cells	O15530;P13727;Q05655	5170;5553;5580	MI:0019-coimmunoprecipitation	GO:0043551	regulation of phosphatidylinositol 3-kinase activity	None	None	9748166	PDK1-dependent phosphorylation of PKCdelta in vitro was stimulated by combined PKC and PDK1 activators. (PMID:9748166)	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	3-phosphoinositide-dependent protein kinase 1;Bone marrow proteoglycan;Protein kinase C delta type	PDPK1;PRG2;PRKCD	PDK1;MBP;PKCD
8225	PRKCZ-PDPK1-PRG2 complex	Human	None	Human embryonic kidney (293) cells	O15530;P13727;Q05513	5170;5553;5590	MI:0019-coimmunoprecipitation	GO:0043551	regulation of phosphatidylinositol 3-kinase activity	None	None	9748166	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	3-phosphoinositide-dependent protein kinase 1;Bone marrow proteoglycan;Protein kinase C zeta type	PDPK1;PRG2;PRKCZ	PDK1;MBP;PKC2
8226	PEAK1-PPP1CA-SHC1 complex	Human	PPP1CA -SHC1-SGK269 complex	HEK293  cells	P29353;P62136;Q9H792	6464;5499;79834	MI:0069-mass spectrometry studies of complexes	None	None	None	None	23846654	PPP1CA and PPP1CC might be recruited to SHC1 through SGK269, alarge protein with a C-terminal pseudokinase domain and an N-terminalregion with numerous potential sites of phosphorylation and predictedinteraction motifs. (PMID: 23846654)	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	SHC-transforming protein 1;Serine/threonine-protein phosphatase PP1-alpha catalytic subunit;Inactive tyrosine-protein kinase PEAK1	SHC1;PPP1CA;PEAK1	SHC SHCA;PPP1A;KIAA2002
8227	PEAK1-PPP1CC-SHC1 complex	Human	SGK269-PPP1CC-SHC1 complex	HEK293 cells	P29353;P36873;Q9H792	6464;5501;79834	MI:0069-mass spectrometry studies of complexes	None	None	None	None	23846654	PPP1CA and PPP1CC might be recruited to SHC1 through SGK269, alarge protein with a C-terminal pseudokinase domain and an N-terminalregion with numerous potential sites of phosphorylation and predictedinteraction motifs. (PMID: 23846654)	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	SHC-transforming protein 1;Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Inactive tyrosine-protein kinase PEAK1	SHC1;PPP1CC;PEAK1	SHC SHCA;None;KIAA2002
8228	BDKRB2-GNAQ-PECAM1 complex	Human	None	HEK293 cells	P16284;P30411;P50148	5175;624;2776	MI:0007-anti tag coimmunoprecipitation	None	None	None	None	18672896	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Platelet endothelial cell adhesion molecule;B2 bradykinin receptor;Guanine nucleotide-binding protein G(q) subunit alpha	PECAM1;BDKRB2;GNAQ	None;BKR2;GAQ
8229	CDH5-KDR-PECAM1 complex	Human	None	COS-7 cells	P16284;P33151;P35968	5175;1003;3791	MI:0019-coimmunoprecipitation	GO:0034405	response to fluid shear stress	None	None	16163360	PECAM-1 (which directly transmits mechanical force), vascular endothelial cell cadherin (which functions as an adaptor) and VEGFR2 (which activates phosphatidylinositol-3-OH kinase) comprise a mechanosensory complex. Together, these receptors are sufficient to confer responsiveness to flow in heterologous cells.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Platelet endothelial cell adhesion molecule;Cadherin-5;Vascular endothelial growth factor receptor 2	PECAM1;CDH5;KDR	None;None;FLK1 VEGFR2
8230	PELI1-SMAD6 complex	Human	None	None	O43541;Q96FA3	4091;57162	MI:0019-coimmunoprecipitation	GO:0008592	regulation of Toll signaling pathway	None	None	25766838	Smaducin-6 interacted with Pellino-1, located in the inner membrane, thereby disruptingthe formation of IRAK1-, RIP1-, IKKe-mediated TLR4 signaling complexes. (PMID:25766838).	None	None	Homo sapiens (Human);Homo sapiens (Human)	Mothers against decapentaplegic homolog 6;E3 ubiquitin-protein ligase pellino homolog 1	SMAD6;PELI1	MADH6;PRISM
8233	CLDN1-ESAM-OCLN-PECAM1 complex	Human	None	HUVEC cells	O95832;P16284;Q16625;Q96AP7	9076;5175;4950;90952	MI:0019-coimmunoprecipitation	GO:0061028;GO:0007043	establishment of endothelial barrier;cell-cell junction assembly	42.06.04	intercellular junction (gap junction/adherens junction)	26607202	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Claudin-1;Platelet endothelial cell adhesion molecule;Occludin;Endothelial cell-selective adhesion molecule	CLDN1;PECAM1;OCLN;ESAM	CLD1 SEMP1;None;None;None
8234	ESR1-PELP1-SRC complex	Human	ERalpha-MNAR-SRC complex	None	P03372;P12931;Q8IZL8	2099;6714;27043	MI:0096-pull down	None	None	None	None	14963108	MNAR is a scaffold protein that mediates ER-Src interaction and plays an important role in the integration of ER action in Src-mediated signaling. (PMID:14963108)	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Estrogen receptor;Proto-oncogene tyrosine-protein kinase Src;Proline-, glutamic acid- and leucine-rich protein 1	ESR1;SRC;PELP1	ESR NR3A1;SRC1;HMX3 MNAR
8236	PPIH-PRPF3-PRPF4 complex	Human	None	HeLa cells	O43172;O43395;O43447	9128;9129;10465	MI:0071-molecular sieving	GO:0000398	mRNA splicing, via spliceosome	11.04.03	mRNA processing (splicing, 5'-, 3'-end processing)	9404889	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	U4/U6 small nuclear ribonucleoprotein Prp4;U4/U6 small nuclear ribonucleoprotein Prp3;Peptidyl-prolyl cis-trans isomerase H	PRPF4;PRPF3;PPIH	PRP4;HPRP3 PRP3;CYP20 CYPH
8237	XAF1-XIAP complex	Human	None	HEK293 cells	P98170;Q6GPH4	331;54739	MI:0007-anti tag coimmunoprecipitation	GO:0010498	proteasomal protein catabolic process	None	None	17613533	XAF1 mediates Survivin down-regulation through a complex containing XIAP, supporting dual roles for XAF1 in apoptosis and mitotic catastrophe.	None	None	Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase XIAP;XIAP-associated factor 1	XIAP;XAF1	API3 BIRC4 IAP3;BIRC4BP,XIAPAF1
8238	PTEN-PP1MA-SMAD2-SMAD3 complex	Human	None	Human dermal fibroblast cells	P35813;P60484;P84022;Q15796	5494;5728;4088;4087	MI:0019-coimmunoprecipitation	GO:0007179	transforming growth factor beta receptor signaling pathway	30.05.01.18.01	TGF-beta-receptor signalling pathway	18482992	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein phosphatase 1A;Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN;Mothers against decapentaplegic homolog 3;Mothers against decapentaplegic homolog 2	PPM1A;PTEN;SMAD3;SMAD2	PPPM1A;MMAC1, TEP1;MADH3;MADH2 MADR2
8239	PPIE-AQR-XAB2-ISY1-ZNF830 complex	Human	Intron-binding complex; IBC	HeLa cells	O60306;Q96NB3;Q9HCS7;Q9ULR0;Q9UNP9	9716;91603;56949;57461;10450	MI:0029-cosedimentation through density gradient	GO:0000398	mRNA splicing, via spliceosome	11.04.03	mRNA processing (splicing, 5'-, 3'-end processing)	25599396	Nearly all Aquarius in HeLa nuclear extract was present in a pentameric complex, henceforth designated the intron-binding complex (IBC).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	RNA helicase aquarius;Zinc finger protein 830;Pre-mRNA-splicing factor SYF1;Pre-mRNA-splicing factor ISY1 homolog;Peptidyl-prolyl cis-trans isomerase E	AQR;ZNF830;XAB2;ISY1;PPIE	KIAA0560;CCDC16;HCNP KIAA1177 SYF1;KIAA1160;CYP33
8240	BIRC5-XIAP complex	Human	Survivin-XIAP complex	MCF-7 cells	O15392;P98170	332;331	MI:0019-coimmunoprecipitation	GO:0042981;GO:0010498	regulation of apoptotic process;proteasomal protein catabolic process	None	None	15218035	Formation of a BIRC5(survivin)-XIAP complex promotes increased XIAP stability against ubiquitination/proteasomal destruction and synergistic inhibition of apo- ptosis.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Baculoviral IAP repeat-containing protein 5;E3 ubiquitin-protein ligase XIAP	BIRC5;XIAP	API4 IAP4;API3 BIRC4 IAP3
8241	PPIH-PRPF4 complex	Human	None	None	O43172;O43447	9128;10465	MI:0071-molecular sieving	GO:0000398	mRNA splicing, via spliceosome	11.04.03	mRNA processing (splicing, 5'-, 3'-end processing)	11823439	USA-CyP forms separate, stable complexes with hPrp18 and hPrp4 in which the active site of the cyclophilin is exposed. (PMID:11823439)	None	None	Homo sapiens (Human);Homo sapiens (Human)	U4/U6 small nuclear ribonucleoprotein Prp4;Peptidyl-prolyl cis-trans isomerase H	PRPF4;PPIH	PRP4;CYP20 CYPH
8242	PPIH-PRPf18 complex	Human	None	HeLa cells	O43447;Q99633	10465;8559	MI:0071-molecular sieving	GO:0000398	mRNA splicing, via spliceosome	11.04.03	mRNA processing (splicing, 5'-, 3'-end processing)	11823439	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Peptidyl-prolyl cis-trans isomerase H;Pre-mRNA-splicing factor 18	PPIH;PRPF18	CYP20 CYPH;HPRP18
8244	PPP1CA-PNUTS-TOX4-WDR82 complex	Human	None	HEK293 cells	O94842;P62136;Q6UXN9;Q96QC0	9878;5499;80335;5514	MI:0029-cosedimentation through density gradient	None	None	None	None	20516061	These data reveal that mammalian Wdr82 functions in a variety of cellular processes and reveal a potential role of the PTW/PP1 phosphatase complex in the regulation of chromatin structure during the transition from mitosis into interphase. (PMID:20516061)	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	TOX high mobility group box family member 4;Serine/threonine-protein phosphatase PP1-alpha catalytic subunit;WD repeat-containing protein 82;Serine/threonine-protein phosphatase 1 regulatory subunit 10	TOX4;PPP1CA;WDR82;PPP1R10	C14orf92,KIAA0737;PPP1A;SWD2 TMEM113 WDR82A;CAT53 FB19 PNUTS
8245	PPP1CB-PNUTS-TOX4-WDR82 complex	Human	None	HEK293 cells	O94842;P62140;Q6UXN9;Q96QC0	9878;5500;80335;5514	MI:0029-cosedimentation through density gradient	GO:1902275	regulation of chromatin organization	None	None	20516061	These data reveal that mammalian Wdr82 functions in a variety of cellular processes and reveal a potential role of the PTW/PP1 phosphatase complex in the regulation of chromatin structure during the transition from mitosis into interphase. (PMID:20516061)	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	TOX high mobility group box family member 4;Serine/threonine-protein phosphatase PP1-beta catalytic subunit;WD repeat-containing protein 82;Serine/threonine-protein phosphatase 1 regulatory subunit 10	TOX4;PPP1CB;WDR82;PPP1R10	C14orf92,KIAA0737;None;SWD2 TMEM113 WDR82A;CAT53 FB19 PNUTS
8246	PPP1CC-PNUTS-TOX4-WDR82 complex	Human	None	HEK293 cells	O94842;P36873;Q6UXN9;Q96QC0	9878;5501;80335;5514	MI:0029-cosedimentation through density gradient	GO:1902275	regulation of chromatin organization	None	None	20516061	These data reveal that mammalian Wdr82 functions in a variety of cellular processes and reveal a potential role of the PTW/PP1 phosphatase complex in the regulation of chromatin structure during the transition from mitosis into interphase. (PMID:20516061)	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	TOX high mobility group box family member 4;Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;WD repeat-containing protein 82;Serine/threonine-protein phosphatase 1 regulatory subunit 10	TOX4;PPP1CC;WDR82;PPP1R10	C14orf92,KIAA0737;None;SWD2 TMEM113 WDR82A;CAT53 FB19 PNUTS
8247	EIF2S1-NCK1-PPP1CA-PPP1R15B complex	Human	None	HeLa cells	P05198;P16333;P62136;Q5SWA1	1965;4690;5499;None	MI:0019-coimmunoprecipitation	GO:0070262	peptidyl-serine dephosphorylation	None	None	16835242	Nck is part a large molecular complex containing CReP, PP1c, and subunits of eIF2 that dephosphorylate eIF2 on Ser51. . Thiscomplex is required for proper control of eIF2 phosphorylationon Ser51, eIF2-dependent signaling, and an appropriate cellresponse to ER stress. Importantly, the amount of PP1c foundin this complex is dependent on the presence of Nck because it isgreatly reduced in MEFs deleted of Nck. Based on theseresults, it was proposed that Nck significantly contributes to the organization and/or stability of this CReP/PP1c-containing complex,regulating the amount of PP1c recruited in close proximity toeIF2 and in this manner regulates eIF2 dephosphorylation on Ser51(PMID:16835242)	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Eukaryotic translation initiation factor 2 subunit 1;Cytoplasmic protein NCK1;Serine/threonine-protein phosphatase PP1-alpha catalytic subunit;Protein phosphatase 1 regulatory subunit 15B	EIF2S1;NCK1;PPP1CA;PPP1R15B	EIF2A;NCK;PPP1A;None
8248	RPA1-RPA2-RPA3-XPA complex	Human	None	In vitro	P15927;P23025;P27694;P35244	6118;7507;6117;6119	MI:0071-molecular sieving	GO:0006289	nucleotide-excision repair	None	None	12390028	XPA plays an important role in the DNA damage recognition during human nucleotide excision repair.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Replication protein A 32 kDa subunit;DNA repair protein complementing XP-A cells;Replication protein A 70 kDa DNA-binding subunit;Replication protein A 14 kDa subunit	RPA2;XPA;RPA1;RPA3	REPA2 RPA32 RPA34;XPAC;REPA1 RPA70;REPA3 RPA14
8249	CETN2-RAD23B-XPC complex	Human	CEN2-HR23B-XPC complex	HeLa cells	P41208;P54727;Q01831	1069;5887;7508	MI:0019-coimmunoprecipitation;MI:0029-cosedimentation through density gradient;MI:0226-ion exchange chromatography	GO:0006289;GO:0005634	nucleotide-excision repair;nucleus	70.10	nucleus	11279143	CETN2 interacts directly with XPC, and, in cooperation with RAD23B, stabilizes XPC, which stimulates XPC nucleotide excision repair activity in vitro.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Centrin-2;UV excision repair protein RAD23 homolog B;DNA repair protein complementing XP-C cells	CETN2;RAD23B;XPC	CALT CEN2;None;XPCC
8250	CETN2-RAD23A-XPC complex	Human	CEN2-HR23A-XPC complex	HeLa cells	P41208;P54725;Q01831	1069;5886;7508	MI:0019-coimmunoprecipitation;MI:0029-cosedimentation through density gradient;MI:0226-ion exchange chromatography	GO:0005634;GO:0006289	nucleus;nucleotide-excision repair	70.10	nucleus	11279143	It is assumed that, in analogy to the CETN2-RAD23B-XPC complex, the CETN2-RAD23A-XPC complex in involved in nucleotide excision repair.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Centrin-2;UV excision repair protein RAD23 homolog A;DNA repair protein complementing XP-C cells	CETN2;RAD23A;XPC	CALT CEN2;None;XPCC
8251	RAN-RANBP3-XPO1 complex	Human	RanGTP-RANBP3-CRM1 complex	HeLa cells	O14980;P62826;Q9H6Z4	7514;5901;8498	MI:0007-anti tag coimmunoprecipitation	GO:0006611;GO:0005737;GO:0005634	protein export from nucleus;cytoplasm;nucleus	70.03;70.10	cytoplasm;nucleus	11571268	RanBP3 can form a tight complex with XPO1 (CRM1) and RAN (RanGTP) that is resistant to RanBP1-mediated dissociation and that is leptomycin B insensitive. RanBP3 functions by a novel mechanism as a cofactor in recognition and protein export of certain CRM1 substrates.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Exportin-1;GTP-binding nuclear protein Ran;Ran-binding protein 3	XPO1;RAN;RANBP3	CRM1;ARA24;None
8252	RAN-XPO4 complex	Human	RanGTP-Exportin complex	HeLa cells	P62826;Q9C0E2	5901;64328	MI:0007-anti tag coimmunoprecipitation	GO:0006611;GO:0005737;GO:0005634	protein export from nucleus;cytoplasm;nucleus	70.03;70.10	cytoplasm;nucleus	10944119	The RAN-XPO4 complex mediates the nuclear export of proteins such as  eIF-5A or SMAD3 (PMID: 16449645).	None	None	Homo sapiens (Human);Homo sapiens (Human)	GTP-binding nuclear protein Ran;Exportin-4	RAN;XPO4	ARA24;KIAA1721
8253	DCTN1-OSBPL1A-RAB7A-RILP complex	Human	p150Glued-ORP1L-RAB7-RILP complex	in vitro	P51149;Q14203;Q96NA2;Q9BXW6	7879;1639;83547;114876	MI:0019-coimmunoprecipitation	GO:0005770;GO:0043231	late endosome;intracellular membrane-bounded organelle	None	None	19564404	Under low cholesterol condi\u00adtions, ORP1L conformation induces the formation of endo\u00adplasmic reticulum (ER)\u2013late endosome (LE) membrane contact sites. At these sites, the ER protein VAMP can interact in trans with the Rab7\u2013RILP complex to remove DCTN1 and associated motors. LEs then move to the microtubule plus end.	Under high cholesterol conditions, as in Niemann Pick type C disease, this process (LEs moves to the microtubule plus end) is prevented, and LEs ac\u00adcumulate at the microtubule minus end as the result of dynein motor activity.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Ras-related protein Rab-7a;Dynactin subunit 1;Rab-interacting lysosomal protein;Oxysterol-binding protein-related protein 1	RAB7A;DCTN1;RILP;OSBPL1A	RAB7;None;None;ORP1 OSBP8 OSBPL1 OSBPL1B
8254	RAN-XPO5 complex	Human	RanGTP-Exp5 complex	HeLa cells	P62826;Q9HAV4	5901;57510	MI:0004-affinity chromatography technology	GO:0006611;GO:0005737;GO:0005634;GO:0006405	protein export from nucleus;cytoplasm;nucleus;RNA export from nucleus	70.03;70.10	cytoplasm;nucleus	12426392	The RAN-XPO5 complex exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm.	None	None	Homo sapiens (Human);Homo sapiens (Human)	GTP-binding nuclear protein Ran;Exportin-5	RAN;XPO5	ARA24;KIAA1291 RANBP21
8255	DNAJB12-DNAJB14-HSPA8-SGTA complex	Human	None	HEK-293T cell	O43765;P11142;Q8TBM8;Q9NXW2	6449;3312;79982;54788	MI:0019-coimmunoprecipitation	GO:0046718;GO:1903513;GO:0036503	viral entry into host cell;endoplasmic reticulum to cytosol transport;ERAD pathway	None	None	24675744	Polyomaviruses, such as SV40, are mobilized out of the ER into the cytosol by binding to SGTA complexed to HSC70-B14-B12. Upon binding of the virus, SGTA and Hsc70 dissociate from the B14-B12 complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Small glutamine-rich tetratricopeptide repeat-containing protein alpha;Heat shock cognate 71 kDa protein;DnaJ homolog subfamily B member 14;DnaJ homolog subfamily B member 12	SGTA;HSPA8;DNAJB14;DNAJB12	SGT,SGT1;HSC70 HSP73 HSPA10;None;None
8256	DNAJB12-DNAJB14 complex	Human	None	HeLa cells	Q8TBM8;Q9NXW2	79982;54788	MI:0019-coimmunoprecipitation;MI:0071-molecular sieving	GO:0005789;GO:1903513	endoplasmic reticulum membrane;endoplasmic reticulum to cytosol transport	None	None	24675744	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	DnaJ homolog subfamily B member 14;DnaJ homolog subfamily B member 12	DNAJB14;DNAJB12	None;None
8257	RAN-XPO6 complex	Human	RanGTP-Exp6 complex	HeLa cells	P62826;Q96QU8	5901;23214	MI:0004-affinity chromatography technology	GO:0006611;GO:0005634;GO:0005737	protein export from nucleus;nucleus;cytoplasm	70.10;70.03	nucleus;cytoplasm	14592989	The RAN-XPO6 complex mediates nuclear export of profilin-actin complexes and other factors which are functionally related and represent either constituents or regulators of the actin cytoskeleton.	None	None	Homo sapiens (Human);Homo sapiens (Human)	GTP-binding nuclear protein Ran;Exportin-6	RAN;XPO6	ARA24;KIAA0370 RANBP20
8258	RAN-XPO7 complex	Human	RanGTP-Exp7 complex	HeLa cells	P62826;Q9UIA9	5901;23039	MI:0004-affinity chromatography technology	GO:0005737;GO:0006611;GO:0005634	cytoplasm;protein export from nucleus;nucleus	70.03;70.10	cytoplasm;nucleus	15282546	The RNA-XPO7 complex functions as nuclear export complex that excludes Rho GTPase-activating protein 1, 14-3-3 protein sigma and apparently numerous other proteins from the nucleus. Beside CRM1, XPO7 appears now to be the second example of an exportin with broad substrate specificity.	None	None	Homo sapiens (Human);Homo sapiens (Human)	GTP-binding nuclear protein Ran;Exportin-7	RAN;XPO7	ARA24;KIAA0745 RANBP16
8259	RAN-XPOT complex	Human	RanGTP-XPOT complex	HeLa cells	O43592;P62826	11260;5901	MI:0004-affinity chromatography technology	GO:0006405;GO:0005737;GO:0005634	RNA export from nucleus;cytoplasm;nucleus	70.03;70.10	cytoplasm;nucleus	9660920	tRNAs are synthesized in the nucleus and after several maturation steps exported to the cytoplasm by the RAN-XPOT complex. XPOT can distinguish tRNA from other highly structured RNA species.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Exportin-T;GTP-binding nuclear protein Ran	XPOT;RAN	None;ARA24
8260	IPO4-RAN complex	Human	None	in vitro	P62826;Q8TEX9	5901;79711	MI:0019-coimmunoprecipitation	GO:0005634;GO:0005737;GO:0006606	nucleus;cytoplasm;protein import into nucleus	70.10;70.03	nucleus;cytoplasm	17682055	In spermatoids,  IPO4 is required for the transport of transition protein 2 into the nucleus.  Binding of RanGTP releases IPO4 from its cargo. In HeLa cells, IPO4 transports the ribosomal protein S3a into the nucleus (PMID: 11823430).	None	None	Homo sapiens (Human);Homo sapiens (Human)	GTP-binding nuclear protein Ran;Importin-4	RAN;IPO4	ARA24;IMP4B, RANBP4
8261	IPO5-RAN complex	Human	RANBP5-RanGTP complex	HeLa cells	O00410;P62826	3843;5901	MI:0004-affinity chromatography technology	GO:0005737;GO:0005634;GO:0006610	cytoplasm;nucleus;ribosomal protein import into nucleus	70.03;70.10	cytoplasm;nucleus	9687515	The import receptor IPO5 binds ribosomal proteins only in the absence of RanGTP, i.e. in the cytoplasm, and releases them upon interaction with RanGTP which should happen in the nucleus where the RanGTP concentration is predicted to be high. In addition, NMDAR (N-methyl-D-aspartate receptor) signaling facilitates the IPO5-mediated nuclear import of CPEB3, a nucleocytoplasm-shuttling RNA-binding protein.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Importin-5;GTP-binding nuclear protein Ran	IPO5;RAN	KPNB3 RANBP5;ARA24
8262	IPO7-RAN complex	Human	RANBP7-RanGTP complex	HeLa cells	O95373;P62826	10527;5901	MI:0004-affinity chromatography technology	GO:0006610;GO:0005737;GO:0005634	ribosomal protein import into nucleus;cytoplasm;nucleus	70.03;70.10	cytoplasm;nucleus	9687515	The import receptor IPO7 binds ribosomal proteins such as S7, L5 and L23a only in the absence of RanGTP, i.e. in the cytoplasm, and releases them upon interaction with RanGTP which should happen in the nucleus where the RanGTP concentration is predicted to be high.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Importin-7;GTP-binding nuclear protein Ran	IPO7;RAN	RANBP7;ARA24
8263	IPO11-RAN complex	Human	RANBP11-RanGTP complex	HEK293 cells	P62826;Q9UI26	5901;51194	MI:0019-coimmunoprecipitation	GO:0006606;GO:0005737;GO:0005634	protein import into nucleus;cytoplasm;nucleus	70.03;70.10	cytoplasm;nucleus	31881079	The import receptor IPO11 binds catenin beta only in the absence of RanGTP, i.e. in the cytoplasm, and release it upon interaction with RanGTP which should happen in the nucleus where the RanGTP concentration is predicted to be high.	IPO11 knockout decreased colony formation of colorectal cancers (CRC) cell lines and decreased proliferation of patient-derived CRC organoids.	None	Homo sapiens (Human);Homo sapiens (Human)	GTP-binding nuclear protein Ran;Importin-11	RAN;IPO11	ARA24;RANBP11
8264	IPO13-RAN complex	Human	RANBP13-RanGTP complex	HeLa cells	O94829;P62826	9670;5901	MI:0004-affinity chromatography technology	GO:0005737;GO:0005634;GO:0006606;GO:0006611	cytoplasm;nucleus;protein import into nucleus;protein export from nucleus	70.03;70.10	cytoplasm;nucleus	11447110	The import receptor IPO13 binds its substrates ribosomal protein L5, the RBM8 protein, MGN, the NF-YB protein as well as the SUMO-conjugating enzyme hUBC9 only in the absence of RanGTP, i.e. in the cytoplasm, and releases them upon interaction with RanGTP which should happen in the nucleus where the RanGTP concentration is predicted to be high. IPO13 also shows export activity towards the translation initiation factor eIF1A.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Importin-13;GTP-binding nuclear protein Ran	IPO13;RAN	KIAA0724 RANBP13;ARA24
8266	PPP3CB-PPP3R1 complex	Human	None	None	P16298;P63098	5532;5534	MI:0069-mass spectrometry studies of complexes;MI:0071-molecular sieving	GO:0006468	protein phosphorylation	14.07.03	modification by phosphorylation, dephosphorylation, autophosphorylation	19154138	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform;Calcineurin subunit B type 1	PPP3CB;PPP3R1	CALNA2 CALNB CNA2;CNA2 CNB
8267	DNAJB14-HSPA1-HSPH8-SGTA complex	Human	DNAJB14-HSPA8-HSPH1-SGTA complex; DNAJB14-HSC70-HSP105-SGTA complex	HEK293T cell	O43765;P11142;Q8TBM8;Q92598	6449;3312;79982;10808	MI:0004-affinity chromatography technology;MI:0006-anti bait coimmunoprecipitation	GO:0036503;GO:0046718;GO:0030163;GO:1903513;GO:0045087;GO:0019048	ERAD pathway;viral entry into host cell;protein catabolic process;endoplasmic reticulum to cytosol transport;innate immune response;modulation by virus of host process	14.13;36.25.16.01	protein/peptide degradation;innate immune response (invertebrates and vertebrates)	26244546	This complex functions as disaggregation machinery in the ER-associated degradation (ERAD) pathway, that involves translocation of a misfolded proteins across the ER membrane to the cytosol. In addition, this complex plays an important role in the SV40 infection process by driving the membrane translocation of the virus. SV40 interacts with Hsp105 to cross the ER membrane and reach the cytosol. (PMID:26244546)	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Small glutamine-rich tetratricopeptide repeat-containing protein alpha;Heat shock cognate 71 kDa protein;DnaJ homolog subfamily B member 14;Heat shock protein 105 kDa	SGTA;HSPA8;DNAJB14;HSPH1	SGT,SGT1;HSC70 HSP73 HSPA10;None;HSP105 HSP110 KIAA0201
8268	PPP3CC-PPP3R1 complex	Human	None	None	P48454;P63098	5533;5534	MI:0069-mass spectrometry studies of complexes;MI:0071-molecular sieving	None	None	None	None	19154138	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform;Calcineurin subunit B type 1	PPP3CC;PPP3R1	CALNA3 CNA3;CNA2 CNB
8270	CCNK-CDK13 complex	Human	CycK-CDK13 complex	HEK293 cells	O75909;Q14004	8812;8621	MI:0007-anti tag coimmunoprecipitation	GO:0006355;GO:0046718	regulation of DNA-templated transcription;viral entry into host cell	11.02.03.04	transcriptional control	22012619	None	The HIV-1-negative factor (Nef) protein interacts with the CycK-CDK13 complex to antagonize SERINC5 for optimal viral infectivity. When the kinase activity of CycK-CDK13 complex is inhibited, HIV-Nef became unable to downregulate SERINC5 which restricts infectivity of HIV. Thus, interfering with CDK13 could be a strategy to attenuate viral replication and spread.(PMID:34380030)	None	Homo sapiens (Human);Homo sapiens (Human)	Cyclin-K;Cyclin-dependent kinase 13	CCNK;CDK13	CPR4;CDC2L CDC2L5 CHED KIAA1791
8271	CCNK-CDK12 complex	Human	CycK-CDK12 complex	HEK293 cells	O75909;Q9NYV4	8812;51755	MI:0007-anti tag coimmunoprecipitation	GO:0006355;GO:0042772;GO:0006974	regulation of DNA-templated transcription;DNA damage response, signal transduction resulting in transcription;cellular response to DNA damage stimulus	11.02.03.04;32.01.09	transcriptional control;DNA damage response	22012619	Depletion of CycK-CDK12 results in decreased expression of predominantly long genes with high numbers of exons. The most prominent group of down-regulated genes are DNA damage response genes, e.g. BRCA1, ATR, FANCI, and FANCD2. Cells without CycK-CDK12 complex induce spontaneous DNA damage.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cyclin-K;Cyclin-dependent kinase 12	CCNK;CDK12	CPR4;CRK7 CRKRS KIAA0904
8272	RAB8A-TNPO1 ciliary transport complex	Human	None	HEK293T cells	P61006;Q92973	4218;3842	MI:0019-coimmunoprecipitation	GO:0042073	intraciliary transport	None	None	27633000	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Ras-related protein Rab-8A;Transportin-1	RAB8A;TNPO1	MEL RAB8;KPNB2 MIP1 TRN
8273	CTLH complex	Human	None	HEK293 cells	Q7L5Y9;Q8IUR7-2;Q8IUR7-6;Q8IVV7;Q96S59;Q9H7D7;Q9H871;Q9NWU2;Q9UL63	10296;25852;25852;79018;10048;80232;64795;54994;4289	MI:0019-coimmunoprecipitation	GO:0043130;GO:0006511	ubiquitin binding;ubiquitin-dependent protein catabolic process	14.13.01.01	proteasomal degradation (ubiquitin/proteasomal pathway)	31285494	None	None	ARMC8-alpha (Q8IUR7-2) and ARMC8-beta (Q8IUR7-6) are splice variants of ARMC8.According to PMID:17467196, isoform ARMC8-alpha is shown in NM_015396, and isoform ARMC8-beta is shown in NM_213654.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein transferase MAEA;Isoform 2 of Armadillo repeat-containing protein 8;Isoform 6 of Armadillo repeat-containing protein 8;Glucose-induced degradation protein 4 homolog;Ran-binding protein 9;WD repeat-containing protein 26;E3 ubiquitin-protein transferase RMND5A;Glucose-induced degradation protein 8 homolog;Muskelin	MAEA;ARMC8;ARMC8;GID4;RANBP9;WDR26;RMND5A;GID8;MKLN1	EMP;None;None;C17orf39,VID24;RANBPM;CDW2 MIP2;None;C20orf11 TWA1;None
8274	IPO9-RAN complex	Human	RanBP9-RanGTP complex	HeLa cells	P62826;Q96P70	5901;55705	MI:0004-affinity chromatography technology	GO:0006610;GO:0005737;GO:0005634	ribosomal protein import into nucleus;cytoplasm;nucleus	70.03;70.10	cytoplasm;nucleus	11823430	The import receptor IPO9 binds its substrates hepatocellular carcinoma-associated protein, the ribosomal proteins S3, S7, S9 and L19, the heat shock protein HSP27 and the core histone H2B only in the absence of RanGTP, i.e. in the cytoplasm, and release them upon interaction with RanGTP which should happen in the nucleus where the RanGTP concentration is predicted to be high.	None	None	Homo sapiens (Human);Homo sapiens (Human)	GTP-binding nuclear protein Ran;Importin-9	RAN;IPO9	ARA24;IMP9 KIAA1192 RANBP9
8275	IPO8-RAN complex	Human	RANBP8-RanGTP complex	HeLa cells	O15397;P62826	10526;5901	MI:0004-affinity chromatography technology	GO:0006606;GO:0005737;GO:0005634	protein import into nucleus;cytoplasm;nucleus	70.03;70.10	cytoplasm;nucleus	11682607	The import receptor IPO8 binds its substrate SRP19 (signal recognition particle) only in the absence of RanGTP, i.e. in the cytoplasm, and release them upon interaction with RanGTP which should happen in the nucleus where the RanGTP concentration is predicted to be high.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Importin-8;GTP-binding nuclear protein Ran	IPO8;RAN	RANBP8;ARA24
8276	IPO7-KPNB1 complex	Human	Importin-RANBP7 complex	HeLa cells; in vitro	O95373;Q14974	10527;3837	MI:0004-affinity chromatography technology	GO:0006606;GO:0005737;GO:0005634	protein import into nucleus;cytoplasm;nucleus	70.03;70.10	cytoplasm;nucleus	12080050	The IPO7-KPNB1 complex binds its substrates H1 histone and ribosomal proteins rpL4 and rpL6 only in the absence of RanGTP, i.e. in the cytoplasm, and release them upon interaction with RanGTP which should happen in the nucleus where the RanGTP concentration is predicted to be high.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Importin-7;Importin subunit beta-1	IPO7;KPNB1	RANBP7;NTF97
8277	TC45-p65 complex	Human	PTPN2-RELA complex	HEK293T cells	P17706-2;Q04206	5771;5970	MI:0019-coimmunoprecipitation	GO:1901222	regulation of NIK/NF-kappaB signaling	None	None	30867837	GdX (UBL4A) interacts with the tyrosine phosphatase TC45 (PTPN2, isofom2), which is known to phosphorylate NF-kappaB-p65. This interaction disrupts the TC45/p65 complex formation leading to enhanced NF-kappaB signaling.	None	TC45 (P17706-2) is a splice variant of PTPN2.	Homo sapiens (Human);Homo sapiens (Human)	Isoform 2 of Tyrosine-protein phosphatase non-receptor type 2;Transcription factor p65	PTPN2;RELA	PTPT;NFKB3
8278	ASAP1-RAB11A-RAB11FIP3 complex	Human	ASAP1-RAB11-FIP3 complex	HEK 293T cells	O75154;P62491;Q9ULH1	9727;8766;50807	MI:0019-coimmunoprecipitation	GO:0055037	recycling endosome	None	None	18685082	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Rab11 family-interacting protein 3;Ras-related protein Rab-11A;Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1	RAB11FIP3;RAB11A;ASAP1	ARFO1,KIAA0665;RAB11;DDEF1 KIAA1249 PAG2
8280	AIM2 PANoptosome complex	Human	None	BMDMs infected with HSV1 or F. novicida	O14862;O15553;P29466;Q13158;Q13546;Q14790;Q9H171;Q9ULZ3;Q9Y572	9447;4210;834;8772;8737;841;81030;29108;11035	MI:0019-coimmunoprecipitation	GO:0061702;GO:0042742;GO:0051607;GO:0045087;GO:0002221;GO:0050727;GO:0042981;GO:1990784	inflammasome complex;defense response to bacterium;defense response to virus;innate immune response;pattern recognition receptor signaling pathway;regulation of inflammatory response;regulation of apoptotic process;response to dsDNA	36.25.16.01	innate immune response (invertebrates and vertebrates)	34471287	Interaction between AIM2, pyrin and ZBP1 drives the assembly of the AIM2 PANoptosome complex. Disruption of the AIM2 PANoptosome complex through deletion of key components inhibited cell death in response to HSV1 and F. novicida infections.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Interferon-inducible protein AIM2;Pyrin;Caspase-1;FAS-associated death domain protein;Receptor-interacting serine/threonine-protein kinase 1;Caspase-8;Z-DNA-binding protein 1;Apoptosis-associated speck-like protein containing a CARD;Receptor-interacting serine/threonine-protein kinase 3	AIM2;MEFV;CASP1;FADD;RIPK1;CASP8;ZBP1;PYCARD;RIPK3	None;MEF,TRIM20;IL1BC, IL1BCE;MORT1;RIP, RIP1;MCH5;C20orf183 DLM1;ASC CARD5 TMS1;RIP3
8281	CASP8-FLIP(L) complex	Human	CASP8-FLIP complex	Jurkat cell	O15519-1;Q14790	8837;841	MI:0019-coimmunoprecipitation;MI:0071-molecular sieving	GO:0006915	apoptotic process	40.10.02	apoptosis (type I programmed cell death)	15209560	FLIP(L) activates caspase-8 by forming a heterodimeric enzyme complex.	None	FLIP(L) (O15519-1) is a splice variant of CFLAR.	Homo sapiens (Human);Homo sapiens (Human)	Isoform 1 of CASP8 and FADD-like apoptosis regulator;Caspase-8	CFLAR;CASP8	CASH CASP8AP1 CLARP MRIT;MCH5
8282	GUCY2D-RD3 complex	Human	RetGC-RD3 complex	HEK293 cells	Q02846;Q7Z3Z2	3000;343035	MI:0019-coimmunoprecipitation	GO:0004383;GO:0007601	guanylate cyclase activity;visual perception	34.11.01.03	visual transduction	21928830	None	Mutations in GUCY2D can cause multiple cases of congenital blinding disorders in human patients including Leber congenital amaurosis type 1 (LCA1) and dominant cone-rod dystrophy. Mutations in RD3  are associated with Leber congenital amaurosis type 12 (LCA12) (PMID: 21928830).	None	Homo sapiens (Human);Homo sapiens (Human)	Retinal guanylyl cyclase 1;Protein RD3	GUCY2D;RD3	CORD6 GUC1A4 GUC2D RETGC RETGC1;C1orf36
8286	TNFR1-signaling complex I, membrane-bound	Human	TNFR1-associated pro-inflammatory complex I, membrane-bound; Complex I	HT1080 cells	P19438;Q12933;Q13490;Q13546;Q15628	7132;7186;329;8737;8717	MI:0019-coimmunoprecipitation	GO:0033209;GO:0005886;GO:0051092;GO:0050727;GO:0060548;GO:0043066	tumor necrosis factor-mediated signaling pathway;plasma membrane;positive regulation of NF-kappaB transcription factor activity;regulation of inflammatory response;negative regulation of cell death;negative regulation of apoptotic process	70.02;40.10.02.01	eukaryotic plasma membrane / membrane attached;anti-apoptosis	12887920	The membrane-associated complex I, triggers a NF-kappaB response, but no apoptosis, whereas the cytoplasmic complex II initiates apoptosis, provided that the NF-kappaB signal from complex I fails to induce the expression of antiapoptotic proteins such as FLIPL.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Tumor necrosis factor receptor superfamily member 1A;TNF receptor-associated factor 2;Baculoviral IAP repeat-containing protein 2;Receptor-interacting serine/threonine-protein kinase 1;Tumor necrosis factor receptor type 1-associated DEATH domain protein	TNFRSF1A;TRAF2;BIRC2;RIPK1;TRADD	TNFAR, TNFR1;TRAP3;API1 MIHB RNF48;RIP, RIP1;None
8288	Pro-death complex II, cytosolic	Human	Complex II; Pro-necrotic complex II; CASP8-associated complex II, cytosolic	HT1080 cells	Q12933;Q13158;Q13490;Q13546;Q14790;Q15628	7186;8772;329;8737;841;8717	MI:0019-coimmunoprecipitation;MI:0071-molecular sieving	GO:0006915;GO:0033209;GO:0050727;GO:0005737	apoptotic process;tumor necrosis factor-mediated signaling pathway;regulation of inflammatory response;cytoplasm	40.10.02;70.03	apoptosis (type I programmed cell death);cytoplasm	12887920	TNFR1-membrane associated complex I triggers a NF-kappaB response, but no apoptosis. Whereas complex II initiates apoptosis, provided that the NF-kappaB signal from complex I fails to induce the expression of anti-apoptotic proteins such as FLIPL.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	TNF receptor-associated factor 2;FAS-associated death domain protein;Baculoviral IAP repeat-containing protein 2;Receptor-interacting serine/threonine-protein kinase 1;Caspase-8;Tumor necrosis factor receptor type 1-associated DEATH domain protein	TRAF2;FADD;BIRC2;RIPK1;CASP8;TRADD	TRAP3;MORT1;API1 MIHB RNF48;RIP, RIP1;MCH5;None
8290	RAN-TNPO3 complex	Human	RanGTP-IPO12 complex	in vitro	P62826;Q9Y5L0	5901;23534	MI:0114-x-ray crystallography	GO:0006606;GO:0005737;GO:0005634	protein import into nucleus;cytoplasm;nucleus	70.03;70.10	cytoplasm;nucleus	24449914	TPNO3 was shown to execute the nuclear import of SRSF1 (ASF/SF2) and SRSF2 (SC35).	None	None	Homo sapiens (Human);Homo sapiens (Human)	GTP-binding nuclear protein Ran;Transportin-3	RAN;TNPO3	ARA24;IPO12
8293	RAN-TNPO1 complex	Human	karyopherin-beta2-Ran x GppNHp complex	in vitro	P62826;Q92973	5901;3842	MI:0114-x-ray crystallography	GO:0006606;GO:0005737;GO:0005634	protein import into nucleus;cytoplasm;nucleus	70.03;70.10	cytoplasm;nucleus	10353245	The import receptor TNPO1 (TRN1) binds its substrates in the absence of RanGTP, i.e. in the cytoplasm, and release them upon interaction with RanGTP which should happen in the nucleus where the RanGTP concentration is predicted to be high. TNPO1 mediates the transport for heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1), hnRNP D, TAP, a ribosomal protein L23a, c-Fos, HIV Rev, and others.	None	None	Homo sapiens (Human);Homo sapiens (Human)	GTP-binding nuclear protein Ran;Transportin-1	RAN;TNPO1	ARA24;KPNB2 MIP1 TRN
8294	PANoptosome	Human	None	HEK293T cells	Q13158;Q13546;Q14790;Q96P20;Q9H171;Q9ULZ3;Q9Y572	8772;8737;841;114548;81030;29108;11035	MI:0019-coimmunoprecipitation	GO:0045087;GO:0002221;GO:0051607;GO:0042742;GO:0061702;GO:0050727;GO:0042981;GO:0043067	innate immune response;pattern recognition receptor signaling pathway;defense response to virus;defense response to bacterium;inflammasome complex;regulation of inflammatory response;regulation of apoptotic process;regulation of programmed cell death	36.25.16.01;40.10.02.04	innate immune response (invertebrates and vertebrates);regulation of apoptosis	32547960	The PANoptosome collectively activates pyroptosis, apoptosis, and necroptosis to circumvent pathogen-mediated inhibition of individual death pathways.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	FAS-associated death domain protein;Receptor-interacting serine/threonine-protein kinase 1;Caspase-8;NACHT, LRR and PYD domains-containing protein 3;Z-DNA-binding protein 1;Apoptosis-associated speck-like protein containing a CARD;Receptor-interacting serine/threonine-protein kinase 3	FADD;RIPK1;CASP8;NLRP3;ZBP1;PYCARD;RIPK3	MORT1;RIP, RIP1;MCH5;C1orf7 CIAS1 NALP3 PYPAF1;C20orf183 DLM1;ASC CARD5 TMS1;RIP3
8296	RIPK3-ZBP1 complex	Human	None	HEK293T cell, infected with influenza A virus	Q9H171;Q9Y572	81030;11035	MI:0019-coimmunoprecipitation	GO:0045087;GO:0051607;GO:0043067;GO:0002221;GO:0051092;GO:0032481;GO:0097300;GO:1990784	innate immune response;defense response to virus;regulation of programmed cell death;pattern recognition receptor signaling pathway;positive regulation of NF-kappaB transcription factor activity;positive regulation of type I interferon production;programmed necrotic cell death;response to dsDNA	36.25.16.01;40.10.02.04	innate immune response (invertebrates and vertebrates);regulation of apoptosis	32298652	Caspase-6 interacts with RIPK3 and facilitates the RIPK3-ZBP1 complex formation.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Z-DNA-binding protein 1;Receptor-interacting serine/threonine-protein kinase 3	ZBP1;RIPK3	C20orf183 DLM1;RIP3
8299	RAN-RANBP1 complex	Human	None	HeLa cells	P43487;P62826	5902;5901	MI:0226-ion exchange chromatography	GO:0006913;GO:0005737	nucleocytoplasmic transport;cytoplasm	70.03	cytoplasm	7882974	RanBP1 increases GTP hydrolysis mediated by RANGAP1.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Ran-specific GTPase-activating protein;GTP-binding nuclear protein Ran	RANBP1;RAN	None;ARA24
8300	RAN-RANBP1-RCC1 complex	Human	None	In vitro	P18754;P43487;P62826	1104;5902;5901	MI:0071-molecular sieving	GO:0000278	mitotic cell cycle	10.03.01.01	mitotic cell cycle	7882974	RCC1 is Ran\u2019s chromatin-bound exchange factor, and RanBP1 is a conserved Ran-GTP-binding protein that has been implicated as a mitotic regulator of RCC1 in embryonic systems. Results show that RanBP1 controls mitotic RCC1 dynamics in human somatic tissue culture cells (PMID: 32594833).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Regulator of chromosome condensation;Ran-specific GTPase-activating protein;GTP-binding nuclear protein Ran	RCC1;RANBP1;RAN	CHC1;None;ARA24
8301	AIPL1 chaperone complex	Human	None	retina;  Y79 retinoblastoma cells	P07900;P0DMV8;P11142;Q9NZN9	3320;3303;3312;23746	MI:0019-coimmunoprecipitation	GO:0061077;GO:0007601	chaperone-mediated protein folding;visual perception	34.11.01.03	visual transduction	18408180	None	AIPL1 mutations cause the severe inherited blindness Leber congenital amaurosis (LCA).	Since the authors did not specify HSP90alpha/beta and HSP70, we used HSP90AA1  and HSPA1A, respectively. NUB1, which has been found in the complex, is a substrate of the AIPL1 chaperone complex.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Heat shock protein HSP 90-alpha;Heat shock 70 kDa protein 1A;Heat shock cognate 71 kDa protein;Aryl-hydrocarbon-interacting protein-like 1	HSP90AA1;HSPA1A;HSPA8;AIPL1	HSP90A HSPC1 HSPCA;HSP72 HSPA1 HSX70;HSC70 HSP73 HSPA10;AIPL2
8302	FADDosome complex, TRAIL-R induced	Human	CASP8-FADD-CASP8 complex	HeLa cells; HT-29 cells	Q13158;Q13546;Q14790	8772;8737;841	MI:0019-coimmunoprecipitation	GO:0007249;GO:0001816	I-kappaB kinase/NF-kappaB signaling;cytokine production	30.01.05.01.04	NIK-I-kappaB/NF-kappaB cascade	28212752	TRAIL-R stimulation promoted the assembly of the FADDosome to promote NF-kappaB activation and pro-inflammatory cytokine/chemokine production.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	FAS-associated death domain protein;Receptor-interacting serine/threonine-protein kinase 1;Caspase-8	FADD;RIPK1;CASP8	MORT1;RIP, RIP1;MCH5
8303	GRIN1-GRIN2b-PPR7	Human	None	HEK293 cells	Q05586;Q13224;Q8TB68	2902;2904;80758	MI:0019-coimmunoprecipitation	GO:0048167	regulation of synaptic plasticity	None	None	27458189	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Glutamate receptor ionotropic, NMDA 1;Glutamate receptor ionotropic, NMDA 2B;Proline-rich protein 7	GRIN1;GRIN2B;PRR7	NMDAR1;NMDAR2B;None
8305	PP6 holoenzyme	Human	ANKRD28-ANKRD44-ANKRD52-PPP6C-PPP6R1-PPP6R2-PPP6R3-IGBP1 complex	HeLa cells	O00743;O15084;O75170;P78318;Q5H9R7;Q8N8A2;Q8NB46;Q9UPN7	5537;23243;9701;3476;55291;91526;283373;22870	MI:0069-mass spectrometry studies of complexes;MI:0071-molecular sieving	GO:0007346	regulation of mitotic cell cycle	None	None	21187329	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein phosphatase 6 catalytic subunit;Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A;Serine/threonine-protein phosphatase 6 regulatory subunit 2;Immunoglobulin-binding protein 1;Serine/threonine-protein phosphatase 6 regulatory subunit 3;Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B;Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C;Serine/threonine-protein phosphatase 6 regulatory subunit 1	PPP6C;ANKRD28;PPP6R2;IGBP1;PPP6R3;ANKRD44;ANKRD52;PPP6R1	PPP6;KIAA0379;KIAA0685 PP6R2 SAPS2;IBP1;C11orf23 KIAA1558 PP6R3 SAPL SAPS3;None;None;KIAA1115 PP6R1 SAPS1
8306	Ragulator complex	Human	LAMTOR1-LAMTOR2-LAMTOR3 complex; p18-p14-MP1 complex	HEK-293T cells	Q6IAA8;Q9UHA4;Q9Y2Q5	55004;8649;28956	MI:0019-coimmunoprecipitation	GO:0005765;GO:1904263;GO:0043408;GO:0071230	lysosomal membrane;positive regulation of TORC1 signaling;regulation of MAPK cascade;cellular response to amino acid stimulus	None	None	20381137	None	Mutations in LAMTOR2 (p14) causes a pronounced growth defect in humans. (PMID:17195838)	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Ragulator complex protein LAMTOR1;Ragulator complex protein LAMTOR3;Ragulator complex protein LAMTOR2	LAMTOR1;LAMTOR3;LAMTOR2	C11orf59 PDRO;MAP2K1IP1 MAPKSP1;MAPBPIP ROBLD3
8307	Ragulator-Rag complex	Human	LAMTOR1-LAMTOR2-LAMTOR3-RRAGB-RRAGD	HEK-293T cells	Q5VZM2;Q6IAA8;Q9NQL2;Q9UHA4;Q9Y2Q5	10325;55004;58528;8649;28956	MI:0019-coimmunoprecipitation	GO:0005765;GO:1904263;GO:0071230	lysosomal membrane;positive regulation of TORC1 signaling;cellular response to amino acid stimulus	None	None	20381137	The Ragulator-Rag complex serves as an amino acid-regulated docking site for mTORC1 on lysosomal membranes.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Ras-related GTP-binding protein B;Ragulator complex protein LAMTOR1;Ras-related GTP-binding protein D;Ragulator complex protein LAMTOR3;Ragulator complex protein LAMTOR2	RRAGB;LAMTOR1;RRAGD;LAMTOR3;LAMTOR2	None;C11orf59 PDRO;None;MAP2K1IP1 MAPKSP1;MAPBPIP ROBLD3
8308	PCGF5\u2013RING1B\u2013UBE2D3 complex	Human	PCGF5\u2013RING1B\u2013UbcH5c complex	None	P35226;P61077;Q99496	648;7323;6045	MI:0114-x-ray crystallography	None	None	None	None	26151332	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Polycomb complex protein BMI-1;Ubiquitin-conjugating enzyme E2 D3;E3 ubiquitin-protein ligase RING2	BMI1;UBE2D3;RNF2	PCGF4 RNF51;UBC5C UBCH5C;BAP1 DING HIPI3 RING1B
8309	BRCA2-PALB2-RAD51-RAD51C-XRCC3 complex	Human	HR complex	EUFA1341 cells	O43502;O43542;P51587;Q06609;Q86YC2	5889;7517;675;5888;79728	MI:0007-anti tag coimmunoprecipitation	GO:0000724	double-strand break repair via homologous recombination	None	None	24141787	The HR-complex functions in DNA double-strand break-induced DNA repair by  homologous recombination.	Germ-line mutations in the BRCA2, PALB2 and RAD51C DNA repair genes have an increased lifetime risk of developing breast, ovarian and other cancers; bi-allelic mutations in these genes clinically manifest as Fanconi anemia.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA repair protein RAD51 homolog 3;DNA repair protein XRCC3;Breast cancer type 2 susceptibility protein;DNA repair protein RAD51 homolog 1;Partner and localizer of BRCA2	RAD51C;XRCC3;BRCA2;RAD51;PALB2	RAD51L2;None;FACD FANCD1;RAD51A RECA;FANCN
8310	mTORC1-PRAS40 complex	Human	AKT1S1-MLST8-MTOR-RPTOR complex	HEK293 cells	P42345;Q8N122;Q96B36;Q9BVC4	2475;57521;84335;64223	MI:0006-anti bait coimmunoprecipitation	GO:0071230;GO:0032869;GO:0031931;GO:0038202;GO:0005764;GO:0001558;GO:0042127;GO:0006468;GO:0051726	cellular response to amino acid stimulus;cellular response to insulin stimulus;TORC1 complex;TORC1 signaling;lysosome;regulation of cell growth;regulation of cell population proliferation;protein phosphorylation;regulation of cell cycle	70.25;14.07.03;10.03.01	vacuole or lysosome;modification by phosphorylation, dephosphorylation, autophosphorylation;mitotic cell cycle and cell cycle control	17604271	None	Deregulation of mTORC1 is common in human cancers. (PMID:20542007)	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein kinase mTOR;Regulatory-associated protein of mTOR;Proline-rich AKT1 substrate 1;Target of rapamycin complex subunit LST8	MTOR;RPTOR;AKT1S1;MLST8	FRAP FRAP1 FRAP2 RAFT1 RAPT1;KIAA1303 RAPTOR;PRAS40;GBL, LST8
8311	NHEJ1-XRCC4 complex	Human	XLF-XRCC4 complex	in vitro	Q13426;Q9H9Q4	7518;79840	MI:0040-electron microscopy;MI:0114-x-ray crystallography;MI:0412-electrophoretic mobility supershift assay	GO:0000724	double-strand break repair via homologous recombination	None	None	22287571	NHEJ1 (XLF) directly interacts with XRCC4 and stimulates XRCC4\u2013DNA Ligase IV joining of DNA ends. The NHEJ1-XRCC4 complex functions independent of DNA Ligase IV in bridging DNA double-strand breaks.	None	None	Homo sapiens (Human);Homo sapiens (Human)	DNA repair protein XRCC4;Non-homologous end-joining factor 1	XRCC4;NHEJ1	None;XLF
8313	PPP4C-PPP4R1 complex	Human	None	None	P60510;Q8TF05	5531;9989	MI:0019-coimmunoprecipitation	GO:0004722	protein serine/threonine phosphatase activity	None	None	11729228	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein phosphatase 4 catalytic subunit;Serine/threonine-protein phosphatase 4 regulatory subunit 1	PPP4C;PPP4R1	PPP4 PPX;MEG1 PP4R1
8314	PPP4C-PPP4R2-PPP4R3B complex	Human	None	HeLa cell	P60510;Q5MIZ7;Q9NY27	5531;57223;151987	MI:0019-coimmunoprecipitation	GO:0006470;GO:0016791	protein dephosphorylation;phosphatase activity	14.07.03	modification by phosphorylation, dephosphorylation, autophosphorylation	18614045	PPP4C-PPP4R2-PPP4R3B complex specifically dephosphorylates ATR-mediated gamma-H2AX generated during DNA replication.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein phosphatase 4 catalytic subunit;Serine/threonine-protein phosphatase 4 regulatory subunit 3B;Serine/threonine-protein phosphatase 4 regulatory subunit 2	PPP4C;PPP4R3B;PPP4R2	PPP4 PPX;KIAA1387 PP4R3B SMEK2;None
8315	PPP4C-PPP4R2-PPP4R3A complex	Human	None	HeLa cells	P60510;Q6IN85;Q9NY27	5531;55671;151987	MI:0019-coimmunoprecipitation	GO:0016791;GO:0006470	phosphatase activity;protein dephosphorylation	14.07.03	modification by phosphorylation, dephosphorylation, autophosphorylation	18614045	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein phosphatase 4 catalytic subunit;Serine/threonine-protein phosphatase 4 regulatory subunit 3A;Serine/threonine-protein phosphatase 4 regulatory subunit 2	PPP4C;PPP4R3A;PPP4R2	PPP4 PPX;KIAA2010 PP4R3A SMEK1;None
8316	PPP4C-PPP4R4 complex	Human	None	None	P60510;Q6NUP7	5531;57718	MI:0069-mass spectrometry studies of complexes	GO:0005829;GO:0004722	cytosol;protein serine/threonine phosphatase activity	None	None	18715871	PP4R4 forms a novel cytosolic complex with PP4c, independent from the complexes containing PP4R1, PP4R2\u00b7PP4R3, and alpha4, and  the regulatory subunits of PP4c have evolved different modes of interaction with the catalytic subunit. (PMID:18715871)	None	None	Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein phosphatase 4 catalytic subunit;Serine/threonine-protein phosphatase 4 regulatory subunit 4	PPP4C;PPP4R4	PPP4 PPX;KIAA1622 PP4R4
8317	AKT1-CDC37-CDK4-HSPA1A-HSP90AA1-NR3C1-PPP5C-RAF1-TSC1-TSC2 complex	Human	None	HEK293 cells	P04049;P04150;P07900;P0DMV8;P11802;P31749;P49815;P53041;Q16543;Q92574	5894;2908;3320;3303;1019;207;7249;5536;11140;7248	MI:0019-coimmunoprecipitation	None	None	None	None	29127155	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	RAF proto-oncogene serine/threonine-protein kinase;Glucocorticoid receptor;Heat shock protein HSP 90-alpha;Heat shock 70 kDa protein 1A;Cyclin-dependent kinase 4;RAC-alpha serine/threonine-protein kinase;Tuberin;Serine/threonine-protein phosphatase 5;Hsp90 co-chaperone Cdc37;Hamartin	RAF1;NR3C1;HSP90AA1;HSPA1A;CDK4;AKT1;TSC2;PPP5C;CDC37;TSC1	RAF;GRL;HSP90A HSPC1 HSPCA;HSP72 HSPA1 HSX70;None;PKB RAC;TSC4;PPP5;CDC37A;KIAA0243, TSC
8318	HSP90AA1-TSC1-TSC2 complex	Human	None	HEK293 cells	P07900;P49815;Q92574	3320;7249;7248	MI:0019-coimmunoprecipitation	None	None	None	None	29127155	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Heat shock protein HSP 90-alpha;Tuberin;Hamartin	HSP90AA1;TSC2;TSC1	HSP90A HSPC1 HSPCA;TSC4;KIAA0243, TSC
8319	PPP6C-TRIM14-WHIP complex	Human	None	THP-1 cells	O00743;Q14142;Q96S55	5537;9830;56897	MI:0019-coimmunoprecipitation;MI:0004-affinity chromatography technology	GO:0045087;GO:0002221;GO:0039535;GO:0005739	innate immune response;pattern recognition receptor signaling pathway;regulation of RIG-I signaling pathway;mitochondrion	36.25.16.01;70.16	innate immune response (invertebrates and vertebrates);mitochondrion	29053956	The WHIP-TRIM14-PPP6C mitochondrial signalosome is required for RIG-I-mediated innate antiviral immunity. This complex pre-exists even without VSV (vesicular stomatitis virus) infection.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein phosphatase 6 catalytic subunit;Tripartite motif-containing protein 14;ATPase WRNIP1	PPP6C;TRIM14;WRNIP1	PPP6;KIAA0129;WHIP
8320	ANKRD28-PPP6C-PPP6R1 complex	Human	None	None	O00743;O15084;Q9UPN7	5537;23243;22870	MI:0019-coimmunoprecipitation;MI:0029-cosedimentation through density gradient	None	None	None	None	18186651	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein phosphatase 6 catalytic subunit;Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A;Serine/threonine-protein phosphatase 6 regulatory subunit 1	PPP6C;ANKRD28;PPP6R1	PPP6;KIAA0379;KIAA1115 PP6R1 SAPS1
8321	ANKRD44-PPP6C-PPP6R1 complex	Human	None	HeLa cells, HEK293 cells	O00743;Q8N8A2;Q9UPN7	5537;91526;22870	MI:0019-coimmunoprecipitation;MI:0029-cosedimentation through density gradient	None	None	None	None	18186651	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein phosphatase 6 catalytic subunit;Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B;Serine/threonine-protein phosphatase 6 regulatory subunit 1	PPP6C;ANKRD44;PPP6R1	PPP6;None;KIAA1115 PP6R1 SAPS1
8322	ANKRD28-PPP6C-PPP6R3 complex	Human	None	HeLa cells, HEK293 cells	O00743;O15084;Q5H9R7	5537;23243;55291	MI:0019-coimmunoprecipitation;MI:0029-cosedimentation through density gradient	None	None	None	None	18186651	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein phosphatase 6 catalytic subunit;Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A;Serine/threonine-protein phosphatase 6 regulatory subunit 3	PPP6C;ANKRD28;PPP6R3	PPP6;KIAA0379;C11orf23 KIAA1558 PP6R3 SAPL SAPS3
8323	ANKRD52-PPP6C-PPP6R1 complex	Human	None	HeLa cells, HEK293 cells	O00743;Q8NB46;Q9UPN7	5537;283373;22870	MI:0019-coimmunoprecipitation;MI:0029-cosedimentation through density gradient	None	None	None	None	18186651	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein phosphatase 6 catalytic subunit;Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C;Serine/threonine-protein phosphatase 6 regulatory subunit 1	PPP6C;ANKRD52;PPP6R1	PPP6;None;KIAA1115 PP6R1 SAPS1
8324	Ragulator complex	Human	LAMTOR complex; LAMTOR1-LAMTOR2-LAMTOR3-LAMTOR4-LAMTOR5 complex	HEK-293T cells	O43504;Q0VGL1;Q6IAA8;Q9UHA4;Q9Y2Q5	10542;389541;55004;8649;28956	MI:0007-anti tag coimmunoprecipitation;MI:0069-mass spectrometry studies of complexes	GO:0006622;GO:1904263;GO:0071230;GO:0005085;GO:0005765	protein targeting to lysosome;positive regulation of TORC1 signaling;cellular response to amino acid stimulus;guanyl-nucleotide exchange factor activity;lysosomal membrane	18.02.03	guanyl-nucleotide exchange factor (GEF)	22980980	Ragulator is a pentameric complex in which HBXIP (LAMTOR5) and C7orf59 (LAMTOR4) form a heterodimer that interacts, through p18 (LAMTOR1), with the MP1-p14 (LAMTOR3-LAMTOR2) heterodimer. HBXIP (LAMTOR5) and C7orf59 (LAMTOR4) are necessary for TORC1 activation by amino acids.	Mutations in LAMTOR2 (p14) causes a pronounced growth defect in humans. (PMID:17195838)	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Ragulator complex protein LAMTOR5;Ragulator complex protein LAMTOR4;Ragulator complex protein LAMTOR1;Ragulator complex protein LAMTOR3;Ragulator complex protein LAMTOR2	LAMTOR5;LAMTOR4;LAMTOR1;LAMTOR3;LAMTOR2	HBXIP,XIP;C7orf59;C11orf59 PDRO;MAP2K1IP1 MAPKSP1;MAPBPIP ROBLD3
8325	Ragulator-Rag complex	Human	Ragulator-Rag complex, expanded	HEK-293T cells	O43504;Q0VGL1;Q6IAA8;Q7L523;Q9HB90;Q9UHA4;Q9Y2Q5	10542;389541;55004;10670;64121;8649;28956	MI:0007-anti tag coimmunoprecipitation	GO:0071230;GO:0005765;GO:1904263	cellular response to amino acid stimulus;lysosomal membrane;positive regulation of TORC1 signaling	None	None	22980980	Ragulator has nucleotide exchange activity toward RagA and RagB and interacts with the Rag heterodimers in an amino acid- and v-ATPase-dependent fashion.	Mutations in LAMTOR2 (p14) causes a pronounced growth defect in humans. (PMID:17195838)	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Ragulator complex protein LAMTOR5;Ragulator complex protein LAMTOR4;Ragulator complex protein LAMTOR1;Ras-related GTP-binding protein A;Ras-related GTP-binding protein C;Ragulator complex protein LAMTOR3;Ragulator complex protein LAMTOR2	LAMTOR5;LAMTOR4;LAMTOR1;RRAGA;RRAGC;LAMTOR3;LAMTOR2	HBXIP,XIP;C7orf59;C11orf59 PDRO;None;None;MAP2K1IP1 MAPKSP1;MAPBPIP ROBLD3
8326	CRX-NR2E3 complex	Human	None	HEK293 cells	O43186;Q9Y5X4	1406;10002	MI:0019-coimmunoprecipitation	GO:0006351;GO:0007601	DNA-templated transcription;visual perception	11;34.11.01.03	TRANSCRIPTION;visual transduction	15689355	None	Mutations in Nr2e3 result in syndromes characterized by excess blue cones and loss of rods: enhanced S-cone syndrome (ESCS) (PMID: 15689355) .	None	Homo sapiens (Human);Homo sapiens (Human)	Cone-rod homeobox protein;Photoreceptor-specific nuclear receptor	CRX;NR2E3	CORD2;PNR,RNR
8327	mTORC2 complex (PROTOR1)	Human	None	HEK-293 cells	P42345;P85299;Q6R327;Q9BPZ7;Q9BVC4	2475;55615;253260;79109;64223	MI:0019-coimmunoprecipitation	GO:0051897;GO:0006468;GO:0030307;GO:0031932;GO:0038203;GO:0007010	positive regulation of protein kinase B signaling;protein phosphorylation;positive regulation of cell growth;TORC2 complex;TORC2 signaling;cytoskeleton organization	14.07.03;42.04	modification by phosphorylation, dephosphorylation, autophosphorylation;cytoskeleton/structural proteins	17461779	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein kinase mTOR;Proline-rich protein 5;Rapamycin-insensitive companion of mTOR;Target of rapamycin complex 2 subunit MAPKAP1;Target of rapamycin complex subunit LST8	MTOR;PRR5;RICTOR;MAPKAP1;MLST8	FRAP FRAP1 FRAP2 RAFT1 RAPT1;PROTOR1;KIAA1999;MIP1, SIN1;GBL, LST8
8328	mTORC2 complex (PROTOR2)	Human	None	HEK-293 cells	P42345;Q6MZQ0;Q6R327;Q9BPZ7;Q9BVC4	2475;79899;253260;79109;64223	MI:0019-coimmunoprecipitation	GO:0051897;GO:0006468;GO:0030307;GO:0031932;GO:0038203;GO:0007010	positive regulation of protein kinase B signaling;protein phosphorylation;positive regulation of cell growth;TORC2 complex;TORC2 signaling;cytoskeleton organization	14.07.03;42.04	modification by phosphorylation, dephosphorylation, autophosphorylation;cytoskeleton/structural proteins	17461779	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein kinase mTOR;Proline-rich protein 5-like;Rapamycin-insensitive companion of mTOR;Target of rapamycin complex 2 subunit MAPKAP1;Target of rapamycin complex subunit LST8	MTOR;PRR5L;RICTOR;MAPKAP1;MLST8	FRAP FRAP1 FRAP2 RAFT1 RAPT1;PROTOR2;KIAA1999;MIP1, SIN1;GBL, LST8
8329	IL15RA-TGFBR2 complex	Human	None	None	P37173;Q13261	7048;3601	MI:0004-affinity chromatography technology	None	None	None	None	34091051	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	TGF-beta receptor type-2;Interleukin-15 receptor subunit alpha	TGFBR2;IL15RA	None;None
8330	KLRC1-KLRD1 complex	Human	CD94-NKG2A complex	None	P26715;Q13241	3821;3824	MI:0069-mass spectrometry studies of complexes	GO:0050776	regulation of immune response	None	None	33415981	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	NKG2-A/NKG2-B type II integral membrane protein;Natural killer cells antigen CD94	KLRC1;KLRD1	NKG2A;CD94
8331	DLD-NFE2L1-RAN complex	Human	DLD-NRF1-RAN complex	Hepatocellular carcinoma cells  (HCC)	P09622;P62826;Q14494	1738;5901;4779	MI:0019-coimmunoprecipitation	GO:0009314	response to radiation	32.01.13	electromagnetic waves stress response (e.g. UV, X-ray)	33508374	NRF1-RAN/-LD complex regulates activity of CLTRN that  enhances radiation sensitivity of hepatocellular carcinoma cells through ferroptosis pathway. (PMID:33508374)	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Dihydrolipoyl dehydrogenase, mitochondrial;GTP-binding nuclear protein Ran;Endoplasmic reticulum membrane sensor NFE2L1	DLD;RAN;NFE2L1	GCSL LAD PHE3;ARA24;HBZ17,NRF1,TCF11
8332	AR-DTX3L-PARP9 complex	Human	AR-Dtx3L-Parp9 complex	HEK293T cells	P10275;Q8IXQ6;Q8TDB6	367;83666;151636	MI:0019-coimmunoprecipitation;MI:0069-mass spectrometry studies of complexes	GO:0006355	regulation of DNA-templated transcription	11.02.03.04	transcriptional control	33976187	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Androgen receptor;Protein mono-ADP-ribosyltransferase PARP9;E3 ubiquitin-protein ligase DTX3L	AR;PARP9;DTX3L	DHTR, NR3C4;BAL BAL1;BBAP
8333	DNMT1-UHRF1-USP7 complex	Human	None	Hepatoblastoma cell	P26358;Q93009;Q96T88	1786;7874;29128	MI:0019-coimmunoprecipitation	GO:0010216;GO:0016570	maintenance of DNA methylation;histone modification	None	None	29507645	The trimeric UHRF1 repression complex might play a crucial role in deep silencing of the TSGs (tumor suppressor genes) HHIP, IGFBP3, and SFRP1 in HB (hepatoblastoma) via combined epigenetic mechanisms, comprising repressive histone modification and DNA methylation. (PMID:29507645)	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DNA;Ubiquitin carboxyl-terminal hydrolase 7;E3 ubiquitin-protein ligase UHRF1	DNMT1;USP7;UHRF1	AIM CXXC9 DNMT;HAUSP;ICBP90 NP95 RNF106
8335	GNAI1-GNB1-GNGT1-NTS-NTSR1 complex	Human	NTS-NTSR1-Galphai1beta1gamma1 complex	None	P30989;P30990;P62873;P63096;P63211	4923;4922;2782;2770;2792	MI:0040-electron microscopy	GO:0007186	G protein-coupled receptor signaling pathway	30.05.02.24	G-protein coupled receptor signalling pathway	33633398	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Neurotensin receptor type 1;Neurotensin/neuromedin N;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;Guanine nucleotide-binding protein G(i) subunit alpha-1;Guanine nucleotide-binding protein G(T) subunit gamma-T1	NTSR1;NTS;GNB1;GNAI1;GNGT1	NTRR;None;None;None;None
8336	CAV1-OCLN-PDCD6IP complex	Human	None	brain pericytes	Q03135;Q16625;Q8WUM4	857;4950;10015	MI:0019-coimmunoprecipitation;MI:0051-fluorescence technology	GO:1903900	regulation of viral life cycle	None	None	33058236	The stability of CAV1-OCLN-PDCD6IP  complex was affected by HIV-1 infection. Modifications of the complex resulted in diminished HIV-1 infection and alterations of the cytokine profile produced by brain pericytes. These results identify a novel mechanism involved in HIV-1 infection contributing to a better understanding of the HIV-1 pathology and the associated neuroinflammatory responses (PMID:33058236).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Caveolin-1;Occludin;Programmed cell death 6-interacting protein	CAV1;OCLN;PDCD6IP	CAV;None;AIP1 ALIX KIAA1375
8337	GSK3B-SRPK1-WNK1 complex	Human	GSK3beta-SRPK1-WNK1 complex	Human colorectal adenocarcinoma cell line HT29	P49841;Q96SB4;Q9H4A3	2932;6732;65125	MI:0019-coimmunoprecipitation	GO:0006468;GO:0051169	protein phosphorylation;nuclear transport	14.07.03;20.09.01	modification by phosphorylation, dephosphorylation, autophosphorylation;nuclear transport	33315986	This complex of three protein kinases, which controls the phosphorylation and nuclear translocation of splicing factor SRSF1 and is targeted by ibuprofen.(PMID:33315986)	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Glycogen synthase kinase-3 beta;SRSF protein kinase 1;Serine/threonine-protein kinase WNK1	GSK3B;SRPK1;WNK1	None;None;HSN2 KDP KIAA0344 PRKWNK1
8338	KEAP1-NRF2 complex	Human	None	HeLa cells, HEK293 cells	Q14145;Q16236	9817;4780	MI:0051-fluorescence technology	GO:0006950;GO:0050727	response to stress;regulation of inflammatory response	32.01	stress response	32786061	Under physiological conditions, KEAP1 protein binds to NRF2 and functions as an adaptor protein for cullin 3 (encoded by Cul3 in humans) E3 ubiquitin ligase, which polyubiquitinates NRF2. Consequently, NRF2 is ubiquitinated and degraded by the proteasome. Hence, the transcriptional activity of NRF2 is potently inhibited under normal conditions. If NRF2 dissociates from the cytoplasmic complex with KEAP1, it enters the nucleus, and accumulates there to drive transcription of genes, which encode a coordinated system of anti-oxidant and anti-inflammatory enzymes (PMID: 29263788).	None	None	Homo sapiens (Human);Homo sapiens (Human)	Kelch-like ECH-associated protein 1;Nuclear factor erythroid 2-related factor 2	KEAP1;NFE2L2	INRF2 KIAA0132 KLHL19;NRF2
8339	ADCYAP1-GNAS-GNB1-GNGT1-VIPR1 complex	Human	Gas-Gbeta-Ggamma-PACAP27 -VIPR1 complex	in vitro	P18509;P32241;P62873;P63092;P63211	116;7433;2782;2778;2792	MI:0051-fluorescence technology	None	None	None	None	32807782	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Pituitary adenylate cyclase-activating polypeptide;Vasoactive intestinal polypeptide receptor 1;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(T) subunit gamma-T1	ADCYAP1;VIPR1;GNB1;GNAS;GNGT1	None;None;None;GNAS1 GSP;None
8340	TTT complex	Human	Triple T complex; TELO2-TTI1-TTI2 complex	U2OS cells	O43156;Q6NXR4;Q9Y4R8	9675;80185;9894	MI:0007-anti tag coimmunoprecipitation;MI:0071-molecular sieving;MI:0418-genetic	GO:0010212;GO:2001020;GO:1901976;GO:0072423	response to ionizing radiation;regulation of response to DNA damage stimulus;regulation of cell cycle checkpoint;response to DNA damage checkpoint signaling	None	None	20810650	TTI1 interacts with TELO2 and  TTI2, to form the TTT complex, a master regulator of DNA damage response signaling.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	TELO2-interacting protein 1 homolog;TELO2-interacting protein 2;Telomere length regulation protein TEL2 homolog	TTI1;TTI2;TELO2	KIAA0406 SMG10;C8orf41;KIAA0683
8341	RUVBL1-RUVBL2-DKC1 complex	Human	DKC1-RUVBL1-RUVBL2 complex; Pontin-Reptin-Dyskerin complex	HEK 293T cells	O60832;Q9Y230;Q9Y265	1736;10856;8607	MI:0007-anti tag coimmunoprecipitation	GO:1905323	telomerase holoenzyme complex assembly	None	None	18358808	Pontin and reptin interact with dyskerin and work together to assemble and stabilize the telomerase TERC ribonucleoprotein.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	H/ACA ribonucleoprotein complex subunit DKC1;RuvB-like 2;RuvB-like 1	DKC1;RUVBL2;RUVBL1	NOLA4;INO80J TIP48 TIP49B;INO80H NMP238 TIP49 TIP49A
8342	RUVBL1-RUVBL2-TERT complex	Human	Pontin-Reptin-TERT complex	HeLa cells	O14746;Q9Y230;Q9Y265	7015;10856;8607	MI:0007-anti tag coimmunoprecipitation	GO:0016887;GO:1905323	ATP hydrolysis activity;telomerase holoenzyme complex assembly	None	None	18358808	Pontin and reptin serve to assemble or remodel a telomerase complex containing TERT. The low catalytic activity of purified Pontin-Reptin-TERT complexes suggest that they may represent a pre-telomerase complex that requires additional factors or remodeling for conversion to a mature telomerase complex. Association of TERT with pontin and reptin is cell cycle dependent, appearing in S phase and diminishing in G2, M and G1 phases.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Telomerase reverse transcriptase;RuvB-like 2;RuvB-like 1	TERT;RUVBL2;RUVBL1	EST2 TCS1 TRT;INO80J TIP48 TIP49B;INO80H NMP238 TIP49 TIP49A
8343	SMG1 complex	Human	SMG1-SMG8-SMG9 complex	HeLa cells	Q8ND04;Q96Q15;Q9H0W8	55181;23049;56006	MI:0006-anti bait coimmunoprecipitation;MI:0071-molecular sieving	GO:0004674;GO:2000622;GO:0005737	protein serine/threonine kinase activity;regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;cytoplasm	70.03	cytoplasm	19417104	SMG-9 is required for association of SMG-1 with SMG-8.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Nonsense-mediated mRNA decay factor SMG8;Serine/threonine-protein kinase SMG1;Nonsense-mediated mRNA decay factor SMG9	SMG8;SMG1;SMG9	ABC2 C17orf71;ATX KIAA0421 LIP;C19orf61
8344	RUVBL1-RUVBL2 complex	Human	TIP49a-TIP49b complex	HeLa cell nuclear extracts	Q9Y230;Q9Y265	10856;8607	MI:0006-anti bait coimmunoprecipitation;MI:0071-molecular sieving	GO:0005634;GO:0016887	nucleus;ATP hydrolysis activity	70.10	nucleus	10428817	TIP48/TIP49 complex formation resulted in synergistic increase in ATPase activity, but no no DNA helicase or branch migration activity could be detected. TIP48/TIP49 complex consisted of two stacked hexameric rings with C6 symmetry. (PMID:17157868)	None	None	Homo sapiens (Human);Homo sapiens (Human)	RuvB-like 2;RuvB-like 1	RUVBL2;RUVBL1	INO80J TIP48 TIP49B;INO80H NMP238 TIP49 TIP49A
8345	DHFR-SHMT1-TYMS complex	Human	None	in vitro	P00374;P04818;P34896	1719;7298;6470	MI:0004-affinity chromatography technology	GO:0006231;GO:0005829;GO:0009165	dTMP biosynthetic process;cytosol;nucleotide biosynthetic process	None	None	34694685	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Dihydrofolate reductase;Thymidylate synthase;Serine hydroxymethyltransferase, cytosolic	DHFR;TYMS;SHMT1	None;TS;None
8346	DRD2-GNAI1 complex	Human	None	in vitro	P14416;P63096	1813;2770	MI:0040-electron microscopy;MI:0114-x-ray crystallography	None	None	None	None	32528175	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	D(2) dopamine receptor;Guanine nucleotide-binding protein G(i) subunit alpha-1	DRD2;GNAI1	None;None
8347	NOL11-UTP4-WDR43 complex	Human	NOL11-WDR43-Cirhin complex, NWC complex	HeLa cells	Q15061;Q969X6;Q9H8H0	23160;84916;25926	MI:0019-coimmunoprecipitation;MI:0051-fluorescence technology	GO:0005730;GO:0007059	nucleolus;chromosome segregation	70.10.07;10.03.04.05	nucleolus;chromosome segregation/division	32479628	This complex, referred to here as the NWC (NOL11-WDR43-Cirhin) complex, exists in nucleoli during interphase and translocates to the periphery of mitotic chromosomes, i.e., perichromosomal regions. During mitotic progression, both the congression of chromosomes to the metaphase plate and sister chromatid cohesion are impaired in the absence of the NWC complex, as it is required for the centromeric enrichment of Aurora B and the associating phosphorylation of histone H3 at threonine 3. These results reveal the characteristics of a novel protein complex consisting of nucleolar proteins, which is required for regulating kinetochores and centromeres to ensure faithful chromosome segregation.(PMID:32479628)	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	WD repeat-containing protein 43;U3 small nucleolar RNA-associated protein 4 homolog;Nucleolar protein 11	WDR43;UTP4;NOL11	KIAA0007,UTP5;CIRH1A KIAA1988 cPERP-E;None
8348	AP1G1-LZTFL1-TFRC complex	Human	LZTFL1-AP-1-TfR1 complex	HeLa cells	O43747;P02786;Q9NQ48	164;7037;54585	MI:0019-coimmunoprecipitation	GO:0006886;GO:0048471	intracellular protein transport;perinuclear region of cytoplasm	14.04	protein targeting, sorting and translocation	31895934	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	AP-1 complex subunit gamma-1;Transferrin receptor protein 1;Leucine zipper transcription factor-like protein 1	AP1G1;TFRC;LZTFL1	ADTG CLAPG1;None;None
8349	EGLN3-PKM complex	Human	PHD3-PKM2 complex	None	P14618;Q9H6Z9	5315;112399	MI:0004-affinity chromatography technology;MI:0114-x-ray crystallography	GO:0001666	response to hypoxia	None	None	31760602	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Pyruvate kinase PKM;Prolyl hydroxylase EGLN3	PKM;EGLN3	OIP3 PK2 PK3 PKM2;None
8350	GPN1-GPN3 complex	Human	None	HEK293 cells	Q9HCN4;Q9UHW5	11321;51184	MI:0055-fluorescent resonance energy transfer	GO:0003924;GO:0005525	GTPase activity;GTP binding	16.19.05	GTP binding	31298811	It was proposed that the mechanism controlled by the GPN-loop GTPases needed for nuclear targeting of RNAPII involves a step where Gpn1 and Gpn3 must associate tightly, which occurs through a very large interacting surface composed of numerous residues, to most likely bring together individual and intermediate subassemblies in the process of RNAPII assembly, an essential prerequisite for RNAPII nuclear import.(PMID:31298811)	None	None	Homo sapiens (Human);Homo sapiens (Human)	GPN-loop GTPase 1;GPN-loop GTPase 3	GPN1;GPN3	MBDIN RPAP4 XAB1;ATPBD1C
8351	ANXA2-MMP2-WFDC2 complex	Human	ANXA2-HE4-MMP2 complex	CaoV3, ES-2, OVCAR-3, Ishikawa, A549, HGC-27, SW480, HepG2, HeLa, HT29 and HEK293 cell lines	P07355;P08253;Q14508	302;4313;10406	MI:0019-coimmunoprecipitation	GO:0016477	cell migration	34.05.01	cell migration	31210752	HE4-ANXA2-MMP2 form a protein complex and ANXA2 plays the role of "bridge". They performed together to promote cell migration.(PMID:31210752)	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Annexin A2;72 kDa type IV collagenase;WAP four-disulfide core domain protein 2	ANXA2;MMP2;WFDC2	ANX2 ANX2L4 CAL1H LPC2D;CLG4A;HE4 WAP5
8352	SMAD3-SMAD4-SKIL complex	Human	SNON-SMAD3-SMAD4 Protein Complex	in vitro	P12757;P84022;Q13485	6498;4088;4089	MI:0114-x-ray crystallography	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	None	None	28397834	SnoN, and SMAD heteromers can form a joint structural core for the binding of other transcription modulators.(PMID:28397834)	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Ski-like protein;Mothers against decapentaplegic homolog 3;Mothers against decapentaplegic homolog 4	SKIL;SMAD3;SMAD4	SNO;MADH3;DPC4 MADH4
8353	RAB24-RAB27A-RILP complex	Human	RAB24-RAB27-RILP complex	K562 cells	P51159;Q969Q5;Q96NA2	5873;53917;83547	MI:0019-coimmunoprecipitation	GO:0008333	endosome to lysosome transport	None	None	27550070	Rab24 interacts with the Rab7/Rab interacting lysosomal protein complex to regulate endosomal degradation.(PMID:27550070)	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Ras-related protein Rab-27A;Ras-related protein Rab-24;Rab-interacting lysosomal protein	RAB27A;RAB24;RILP	RAB27;None;None
8354	RHOH-CTNND1 complex	Human	None	Jukart cells	O60716;Q15669	1500;399	MI:0019-coimmunoprecipitation	None	None	None	None	27574848	Due to its interaction with p120 catenin, Kaiso has also been implicated in regulation of tumor cell invasion. (PMID:21468542)	None	None	Homo sapiens (Human);Homo sapiens (Human)	Catenin delta-1;Rho-related GTP-binding protein RhoH	CTNND1;RHOH	KIAA0384;ARHH TTF
8355	AP2-PICALM adaptor complex	Human	Adaptor complex AP2/PICALM	HeLa cells	O95782;P63010;Q13492;Q96CW1	160;163;8301;1173	MI:0019-coimmunoprecipitation	GO:0006914;GO:0072583;GO:0030119;GO:0038024	autophagy;clathrin-dependent endocytosis;AP-type membrane coat adaptor complex;cargo receptor activity	None	None	24067654	Adaptor complex AP2/PICALM, through interaction with LC3, targets Alzheimer\u2019s  APP-CTF for terminal degradation via autophagy.	involved in Alzheimer Disease (OMIM:104300)	Adaptor protein 2 (AP2) is a well-characterized complex involved in clathrin-mediated endocytosis. It is heterotetrameric and consists of four subunits AP2A1, AP2B1, AP2M1, and AP2S1. The authors assume, that protein AP2S1 is also subunit of this complex.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	AP-2 complex subunit alpha-1;AP-2 complex subunit beta;Phosphatidylinositol-binding clathrin assembly protein;AP-2 complex subunit mu	AP2A1;AP2B1;PICALM;AP2M1	ADTAA CLAPA1;ADTB2 CLAPB1;CALM;CLAPM1 KIAA0109
8356	LTO1-YAE1 complex	Human	CIA adapter complex; ORAOV1-YAE1 complex	E. coli	Q8WV07;Q9NRH1	220064;57002	MI:0007-anti tag coimmunoprecipitation;MI:0071-molecular sieving	GO:0097428	protein maturation by iron-sulfur cluster transfer	None	None	26182403	The maturation of the human ABC protein, ABCE1, depends on the LTO1-YAE1 complex. The proposed model is that YAE1 and ORAOV1 form a heterocomplex able to carry apo ABCE1 to the CIA targeting complex in order to promote the insertion of [4Fe-4S] clusters into ABCE1.	None	The complex has also been characterized by 'The human YAE1-ORAOV1 complex of the cytosolic iron-sulfur protein assembly machinery binds a [4Fe-4S] cluster' (Prusty et al., 2021). As the article had no PMID at the time of annotation, we used the PMID of an alternative article that characterized the complex.	Homo sapiens (Human);Homo sapiens (Human)	Protein LTO1 homolog;Protein YAE1 homolog	LTO1;YAE1	ORAOV1,TAOS1;C7orf36 YAE1D1
8357	DNAJB1-HSPA4-HSPA8 complex	Human	Hsc70-DNAJB1-Apg2 complex	amyloid fibrils	P11142;P25685;P34932	3312;3337;3308	MI:0029-cosedimentation through density gradient	GO:0022411	cellular component disassembly	None	None	26300264	This complex  disassembles amyloids within minutes via combined fibril fragmentation and depolymerization (PMID:26300264).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Heat shock cognate 71 kDa protein;DnaJ homolog subfamily B member 1;Heat shock 70 kDa protein 4	HSPA8;DNAJB1;HSPA4	HSC70 HSP73 HSPA10;DNAJ1 HDJ1 HSPF1;APG2
8358	MDM2-RSL1D1-TP53 complex	Human	HDM2-RSL1D1-p53 complex	HCT-8 colorectal cancer cells	O76021;P04637;Q00987	26156;7157;4193	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0008285	negative regulation of cell population proliferation	None	None	34362424	RSL1D1 directly interacted with and recruited p53 to HDM2 to form a ternary RSL1D1/HDM2/p53 protein complex and thereby enhanced p53 ubiquitination and degradation, leading to a decrease in the protein level of p53 (PMID:34362424).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Ribosomal L1 domain-containing protein 1;Cellular tumor antigen p53;E3 ubiquitin-protein ligase Mdm2	RSL1D1;TP53;MDM2	CATX11 CSIG PBK1;P53;None
8359	SMN1-TIMM50a complex	Human	SMN1-TIM50a complex	HeLa cells	Q16637;Q3ZCQ8-2	None;92609	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0005634;GO:0051030;GO:0030532	nucleus;snRNA transport;small nuclear ribonucleoprotein complex	70.10	nucleus	16008839	There are two isoforms of TIM50: The nuclear isoform TIM50a participates in the release of snRNPs and SMN from the Cajal body (this complex). The mitochondrial isoform is an essential component of the TIM23 complex and regulates mitochondrial integrity and cell death. Tim50a can form a complex with SMN in vivo. From in vitro binding studies, it is concluded that coilin, SmB' and SMN can interact with both Tim50a andTim50 isoforms, but the interaction of these proteins in vivo is likely regulated by their subcellular localization.	SMN is mutated in Spinal Muscular Atrophy	The splice variant/isoform TIM50a/TIMM50a is strictly nuclear and enriched in speckles with snRNPs.	Homo sapiens (Human);Homo sapiens (Human)	Survival motor neuron protein;Isoform 2 of Mitochondrial import inner membrane translocase subunit TIM50	SMN1;TIMM50	SMN SMNT;TIM50
8360	E2F5-RBL1-TFDP1 complex	Human	E2F5-DP1-P107 ternary complex	in vitro	P28749;Q14186;Q15329	5933;7027;1875	MI:0114-x-ray crystallography	GO:0007049;GO:0003677;GO:0035189;GO:0003700;GO:0008134	cell cycle;DNA binding;Rb-E2F complex;DNA-binding transcription factor activity;transcription factor binding	10.03;16.03.01	cell cycle;DNA binding	28439018	None	None	Human DP1, E2F5, and DP1 were expressed in E. coli BL21(DE3) cells.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Retinoblastoma-like protein 1;Transcription factor Dp-1;Transcription factor E2F5	RBL1;TFDP1;E2F5	None;DP1;None
8367	PAIP1-YBX2 complex	Human	None	HEK293 cells	Q9H074;Q9Y2T7	10605;51087	MI:0007-anti tag coimmunoprecipitation;MI:0416-fluorescence microscopy	GO:0008494	translation activator activity	None	None	30295753	PAIP1 regulates the translation of YBX2-masked mRNAs during spermiogenesis by formation of the PAIP1-YBX2 complex.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Polyadenylate-binding protein-interacting protein 1;Y-box-binding protein 2	PAIP1;YBX2	None;CSDA3 MSY2
8369	Spliceosome, C complex	Human	None	HeLa S3 nuclear extract	O15234;O43660;O60306;O60508;O75643;O75934;O95926;P08579;P09661;P14678;P38919;P41223;P61326;P62304;P62306;P62308;P62314;P62316;P62318;Q13427;Q13573;Q15029;Q6P2Q9;Q92620;Q96BP3;Q99459;Q9BW85;Q9BZJ0;Q9HCG8;Q9HCS7;Q9NW64;Q9NXE8;Q9P013;Q9ULR0;Q9UMS4;Q9UNP9;Q9UQ35;Q9Y3C6;Q9Y5S9	22794;5356;9716;51362;23020;10286;25949;6629;6627;6628;9775;8896;4116;6635;6636;6637;6632;6633;6634;9360;22938;9343;10594;9785;23398;988;55702;51340;57703;56949;55696;54883;51503;57461;27339;10450;23524;51645;9939	MI:0029-cosedimentation through density gradient;MI:0040-electron microscopy;MI:0400-affinity technology	GO:0071013;GO:0000398	catalytic step 2 spliceosome;mRNA splicing, via spliceosome	11.04.03	mRNA processing (splicing, 5'-, 3'-end processing)	29301961	Compared with the yeast C complex, the structure of the human C complex contains 11 additional proteins, including four peptidyl prolyl isomerases (PPIs), the exon junction complex, U5-40K, RBM22, and Aquarius.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein CASC3;Pleiotropic regulator 1;RNA helicase aquarius;Pre-mRNA-processing factor 17;U5 small nuclear ribonucleoprotein 200 kDa helicase;Pre-mRNA-splicing factor SPF27;Pre-mRNA-splicing factor SYF2;U2 small nuclear ribonucleoprotein B'';U2 small nuclear ribonucleoprotein A';Small nuclear ribonucleoprotein-associated proteins B and B';Eukaryotic initiation factor 4A-III;Protein BUD31 homolog;Protein mago nashi homolog;Small nuclear ribonucleoprotein E;Small nuclear ribonucleoprotein F;Small nuclear ribonucleoprotein G;Small nuclear ribonucleoprotein Sm D1;Small nuclear ribonucleoprotein Sm D2;Small nuclear ribonucleoprotein Sm D3;Peptidyl-prolyl cis-trans isomerase G;SNW domain-containing protein 1;116 kDa U5 small nuclear ribonucleoprotein component;Pre-mRNA-processing-splicing factor 8;Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16;Peptidylprolyl isomerase domain and WD repeat-containing protein 1;Cell division cycle 5-like protein;Splicing factor YJU2;Crooked neck-like protein 1;Pre-mRNA-splicing factor CWC22 homolog;Pre-mRNA-splicing factor SYF1;Pre-mRNA-splicing factor RBM22;Pre-mRNA-splicing factor CWC25 homolog;Spliceosome-associated protein CWC15 homolog;Pre-mRNA-splicing factor ISY1 homolog;Pre-mRNA-processing factor 19;Peptidyl-prolyl cis-trans isomerase E;Serine/arginine repetitive matrix protein 2;Peptidyl-prolyl cis-trans isomerase-like 1;RNA-binding protein 8A	CASC3;PLRG1;AQR;CDC40;SNRNP200;BCAS2;SYF2;SNRPB2;SNRPA1;SNRPB;EIF4A3;BUD31;MAGOH;SNRPE;SNRPF;SNRPG;SNRPD1;SNRPD2;SNRPD3;PPIG;SNW1;EFTUD2;PRPF8;DHX38;PPWD1;CDC5L;YJU2;CRNKL1;CWC22;XAB2;RBM22;CWC25;CWC15;ISY1;PRPF19;PPIE;SRRM2;PPIL1;RBM8A	MLN51;None;KIAA0560;EHB3 PRP17 PRPF17;ASCC3L1 HELIC2 KIAA0788;DAM1;CBPIN GCIPIP;None;None;COD SNRPB1;DDX48, KIAA0111;EDG2;MAGOHA;None;PBSCF;PBSCG;None;SNRPD1;None;None;SKIIP SKIP;KIAA0031 SNRP116;PRPC8;DDX38 KIAA0224 PRP16;KIAA0073;KIAA0432 PCDC5RP;CCDC94;CRN;KIAA1604 NCM;HCNP KIAA1177 SYF1;ZC3H16;CCDC49;C11orf5;KIAA1160;NMP200 PRP19 SNEV;CYP33;KIAA0324 SRL300 SRM300;CYPL1;RBM8
8370	Spliceosome, pre-B complex	Human	None	in vitro	O43172;O43395;O75533;O75643;O94906;O95777;P08579;P09661;P14678;P55769;P62304;P62306;P62308;P62310;P62312;P62314;P62316;P62318;P83876;Q12874;Q13435;Q15029;Q15393;Q15427;Q15428;Q15459;Q53GS9;Q6P2Q9;Q7RTV0;Q8WWY3;Q96DI7;Q9BUQ8;Q9BWJ5;Q9UK45;Q9Y333;Q9Y3B4;Q9Y4Y9;Q9Y4Z0	9128;9129;23451;23020;24148;51691;6629;6627;6628;4809;6635;6636;6637;27258;11157;6632;6633;6634;10907;10946;10992;9343;23450;10262;8175;10291;10713;10594;84844;26121;9410;9416;83443;51690;57819;51639;23658;25804	MI:0029-cosedimentation through density gradient;MI:0040-electron microscopy;MI:0400-affinity technology	GO:0005681;GO:0000398	spliceosomal complex;mRNA splicing, via spliceosome	11.04.03	mRNA processing (splicing, 5'-, 3'-end processing)	30315277	Pre-mRNA splicing is executed by the spliceosome, which undergoes an ordered process of assembly and activation prior to catalysis. The pre-B complex, which bridges the spliceosomal A and B complexes, represents the first and only assembled spliceosome where all five snRNPs are present.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	U4/U6 small nuclear ribonucleoprotein Prp4;U4/U6 small nuclear ribonucleoprotein Prp3;Splicing factor 3B subunit 1;U5 small nuclear ribonucleoprotein 200 kDa helicase;Pre-mRNA-processing factor 6;U6 snRNA-associated Sm-like protein LSm8;U2 small nuclear ribonucleoprotein B'';U2 small nuclear ribonucleoprotein A';Small nuclear ribonucleoprotein-associated proteins B and B';NHP2-like protein 1;Small nuclear ribonucleoprotein E;Small nuclear ribonucleoprotein F;Small nuclear ribonucleoprotein G;U6 snRNA-associated Sm-like protein LSm3;U6 snRNA-associated Sm-like protein LSm6;Small nuclear ribonucleoprotein Sm D1;Small nuclear ribonucleoprotein Sm D2;Small nuclear ribonucleoprotein Sm D3;Thioredoxin-like protein 4A;Splicing factor 3A subunit 3;Splicing factor 3B subunit 2;116 kDa U5 small nuclear ribonucleoprotein component;Splicing factor 3B subunit 3;Splicing factor 3B subunit 4;Splicing factor 3A subunit 2;Splicing factor 3A subunit 1;U4/U6.U5 tri-snRNP-associated protein 2;Pre-mRNA-processing-splicing factor 8;PHD finger-like domain-containing protein 5A;U4/U6 small nuclear ribonucleoprotein Prp31;U5 small nuclear ribonucleoprotein 40 kDa protein;Probable ATP-dependent RNA helicase DDX23;Splicing factor 3B subunit 5;U6 snRNA-associated Sm-like protein LSm7;U6 snRNA-associated Sm-like protein LSm2;Splicing factor 3B subunit 6;U6 snRNA-associated Sm-like protein LSm5;U6 snRNA-associated Sm-like protein LSm4	PRPF4;PRPF3;SF3B1;SNRNP200;PRPF6;LSM8;SNRPB2;SNRPA1;SNRPB;SNU13;SNRPE;SNRPF;SNRPG;LSM3;LSM6;SNRPD1;SNRPD2;SNRPD3;TXNL4A;SF3A3;SF3B2;EFTUD2;SF3B3;SF3B4;SF3A2;SF3A1;USP39;PRPF8;PHF5A;PRPF31;SNRNP40;DDX23;SF3B5;LSM7;LSM2;SF3B6;LSM5;LSM4	PRP4;HPRP3 PRP3;SAP155;ASCC3L1 HELIC2 KIAA0788;C20orf14;None;None;None;COD SNRPB1;NHP2L1;None;PBSCF;PBSCG;None;None;None;SNRPD1;None;DIM1 TXNL4;SAP61;SAP145;KIAA0031 SNRP116;KIAA0017 SAP130;SAP49;SAP62;SAP114;None;PRPC8;None;PRP31;PRP8BP SFP38 WDR57;None;SF3B10;None;C6orf28 G7B;SAP14 SF3B14 SF3B14A;None;None
8371	Spliceosome, B complex	Human	None	in vitro	O43172;O43290;O43395;O43447;O75533;O75554;O75643;O94906;O95777;P08579;P09661;P14678;P55081;P55769;P62304;P62306;P62308;P62310;P62312;P62314;P62316;P62318;P83876;Q12874;Q13435;Q15029;Q15393;Q15427;Q15428;Q15459;Q2TAY7;Q6P2Q9;Q7RTV0;Q8NAV1;Q8WWY3;Q96DI7;Q96NC0;Q9BZL1;Q9UK45;Q9Y333;Q9Y3B4;Q9Y4Y9;Q9Y4Z0	9128;9092;9129;10465;23451;11193;23020;24148;51691;6629;6627;6628;4236;4809;6635;6636;6637;27258;11157;6632;6633;6634;10907;10946;10992;9343;23450;10262;8175;10291;55234;10594;84844;84950;26121;9410;153527;59286;51690;57819;51639;23658;25804	MI:0029-cosedimentation through density gradient;MI:0040-electron microscopy;MI:0400-affinity technology	GO:0005681;GO:0000398	spliceosomal complex;mRNA splicing, via spliceosome	11.04.03	mRNA processing (splicing, 5'-, 3'-end processing)	30315277	Pre-mRNA splicing is executed by the spliceosome, which undergoes an ordered process of assembly and activation prior to catalysis.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	U4/U6 small nuclear ribonucleoprotein Prp4;U4/U6.U5 tri-snRNP-associated protein 1;U4/U6 small nuclear ribonucleoprotein Prp3;Peptidyl-prolyl cis-trans isomerase H;Splicing factor 3B subunit 1;WW domain-binding protein 4;U5 small nuclear ribonucleoprotein 200 kDa helicase;Pre-mRNA-processing factor 6;U6 snRNA-associated Sm-like protein LSm8;U2 small nuclear ribonucleoprotein B'';U2 small nuclear ribonucleoprotein A';Small nuclear ribonucleoprotein-associated proteins B and B';Microfibrillar-associated protein 1;NHP2-like protein 1;Small nuclear ribonucleoprotein E;Small nuclear ribonucleoprotein F;Small nuclear ribonucleoprotein G;U6 snRNA-associated Sm-like protein LSm3;U6 snRNA-associated Sm-like protein LSm6;Small nuclear ribonucleoprotein Sm D1;Small nuclear ribonucleoprotein Sm D2;Small nuclear ribonucleoprotein Sm D3;Thioredoxin-like protein 4A;Splicing factor 3A subunit 3;Splicing factor 3B subunit 2;116 kDa U5 small nuclear ribonucleoprotein component;Splicing factor 3B subunit 3;Splicing factor 3B subunit 4;Splicing factor 3A subunit 2;Splicing factor 3A subunit 1;WD40 repeat-containing protein SMU1;Pre-mRNA-processing-splicing factor 8;PHD finger-like domain-containing protein 5A;Pre-mRNA-splicing factor 38A;U4/U6 small nuclear ribonucleoprotein Prp31;U5 small nuclear ribonucleoprotein 40 kDa protein;Zinc finger matrin-type protein 2;Ubiquitin-like protein 5;U6 snRNA-associated Sm-like protein LSm7;U6 snRNA-associated Sm-like protein LSm2;Splicing factor 3B subunit 6;U6 snRNA-associated Sm-like protein LSm5;U6 snRNA-associated Sm-like protein LSm4	PRPF4;SART1;PRPF3;PPIH;SF3B1;WBP4;SNRNP200;PRPF6;LSM8;SNRPB2;SNRPA1;SNRPB;MFAP1;SNU13;SNRPE;SNRPF;SNRPG;LSM3;LSM6;SNRPD1;SNRPD2;SNRPD3;TXNL4A;SF3A3;SF3B2;EFTUD2;SF3B3;SF3B4;SF3A2;SF3A1;SMU1;PRPF8;PHF5A;PRPF38A;PRPF31;SNRNP40;ZMAT2;UBL5;LSM7;LSM2;SF3B6;LSM5;LSM4	PRP4;None;HPRP3 PRP3;CYP20 CYPH;SAP155;FBP21,FNBP21;ASCC3L1 HELIC2 KIAA0788;C20orf14;None;None;None;COD SNRPB1;None;NHP2L1;None;PBSCF;PBSCG;None;None;None;SNRPD1;None;DIM1 TXNL4;SAP61;SAP145;KIAA0031 SNRP116;KIAA0017 SAP130;SAP49;SAP62;SAP114;None;PRPC8;None;None;PRP31;PRP8BP SFP38 WDR57;None;None;None;C6orf28 G7B;SAP14 SF3B14 SF3B14A;None;None
8372	Spliceosome, A complex	Human	Prespliceosomal A complex	HeLa nuclear extract	A0A024RDW4;O14776;O15042;O43143;O43290;O43390;O43395;O43660;O43670;O43684;O43719;O60506;O60828;O75400;O75533;O75643;O75934;O75937;O75940;O94906;O95400;P07910;P08579;P08621;P09012;P09234;P09651;P09661;P11142;P14678;P17844;P22626;P26368;P35637;P38159;P49756;P51991;P52298;P52756;P61978;P62136;P62304;P62306;P62308;P62314;P62316;P62318;P62995;P67809;P84103;P98175;Q00839;Q01081;Q01130;Q07955;Q08170;Q08211;Q09161;Q12874;Q12905;Q12906;Q12972;Q13242;Q13243;Q13247;Q13435;Q14011;Q14498;Q15029;Q15287;Q15365;Q15393;Q15427;Q15428;Q15459;Q15637;Q15717;Q16629;Q6P2Q9;Q7L014;Q7RTV0;Q86VM9;Q86XP3;Q8IWX8;Q8IWZ8;Q8IX12;Q8IYB3;Q8N163;Q8N302;Q8WYA6;Q92733;Q92841;Q96I25;Q99459;Q99729;Q9BQ61;Q9BQI9;Q9BUJ2;Q9BUQ8;Q9BWJ5;Q9BXP5;Q9H307;Q9NQW1;Q9P013;Q9UHR5;Q9UHX1;Q9UKV3;Q9UMS4;Q9UQ35;Q9UQ88;Q9Y2W2;Q9Y3B4;Q9Y6A4	55082;10915;23350;1665;9092;10236;9129;5356;7756;9184;27336;10492;10084;55660;23451;23020;10286;22826;10285;24148;10421;3183;6629;6625;6626;6631;3178;6627;3312;6628;1655;3181;11338;2521;27316;58517;220988;22916;10181;3190;5499;6635;6636;6637;6632;6633;6634;6434;4904;6428;8241;3192;7307;6427;6426;6429;1660;4686;10946;3608;3609;5511;8683;6430;6431;10992;1153;9584;9343;10921;5093;23450;10262;8175;10291;7536;1994;6432;10594;9879;84844;124245;11325;10523;57794;None;10250;57805;55109;56259;5546;10521;84991;988;3182;79002;83714;11100;9416;83443;51593;5411;25956;51503;29115;22827;22985;27339;23524;728642;51729;51639;29105	MI:0004-affinity chromatography technology;MI:0029-cosedimentation through density gradient;MI:0040-electron microscopy	GO:0005681;GO:0000398	spliceosomal complex;mRNA splicing, via spliceosome	11.04.03	mRNA processing (splicing, 5'-, 3'-end processing)	17332742	Spliceosomes assemble in a series of consecutive steps that produce complexes E, A, B and C.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	ARGL1 protein;Transcription elongation regulator 1;U2 snRNP-associated SURP motif-containing protein;ATP-dependent RNA helicase DHX15;U4/U6.U5 tri-snRNP-associated protein 1;Heterogeneous nuclear ribonucleoprotein R;U4/U6 small nuclear ribonucleoprotein Prp3;Pleiotropic regulator 1;BUB3-interacting and GLEBS motif-containing protein ZNF207;Mitotic checkpoint protein BUB3;HIV Tat-specific factor 1;Heterogeneous nuclear ribonucleoprotein Q;Polyglutamine-binding protein 1;Pre-mRNA-processing factor 40 homolog A;Splicing factor 3B subunit 1;U5 small nuclear ribonucleoprotein 200 kDa helicase;Pre-mRNA-splicing factor SPF27;DnaJ homolog subfamily C member 8;Survival of motor neuron-related-splicing factor 30;Pre-mRNA-processing factor 6;CD2 antigen cytoplasmic tail-binding protein 2;Heterogeneous nuclear ribonucleoproteins C1/C2;U2 small nuclear ribonucleoprotein B'';U1 small nuclear ribonucleoprotein 70 kDa;U1 small nuclear ribonucleoprotein A;U1 small nuclear ribonucleoprotein C;Heterogeneous nuclear ribonucleoprotein A1;U2 small nuclear ribonucleoprotein A';Heat shock cognate 71 kDa protein;Small nuclear ribonucleoprotein-associated proteins B and B';Probable ATP-dependent RNA helicase DDX5;Heterogeneous nuclear ribonucleoproteins A2/B1;Splicing factor U2AF 65 kDa subunit;RNA-binding protein FUS;RNA-binding motif protein, X chromosome;RNA-binding protein 25;Heterogeneous nuclear ribonucleoprotein A3;Nuclear cap-binding protein subunit 2;RNA-binding protein 5;Heterogeneous nuclear ribonucleoprotein K;Serine/threonine-protein phosphatase PP1-alpha catalytic subunit;Small nuclear ribonucleoprotein E;Small nuclear ribonucleoprotein F;Small nuclear ribonucleoprotein G;Small nuclear ribonucleoprotein Sm D1;Small nuclear ribonucleoprotein Sm D2;Small nuclear ribonucleoprotein Sm D3;Transformer-2 protein homolog beta;Y-box-binding protein 1;Serine/arginine-rich splicing factor 3;RNA-binding protein 10;Heterogeneous nuclear ribonucleoprotein U;Splicing factor U2AF 35 kDa subunit;Serine/arginine-rich splicing factor 2;Serine/arginine-rich splicing factor 1;Serine/arginine-rich splicing factor 4;ATP-dependent RNA helicase A;Nuclear cap-binding protein subunit 1;Splicing factor 3A subunit 3;Interleukin enhancer-binding factor 2;Interleukin enhancer-binding factor 3;Nuclear inhibitor of protein phosphatase 1;Serine/arginine-rich splicing factor 9;Serine/arginine-rich splicing factor 5;Serine/arginine-rich splicing factor 6;Splicing factor 3B subunit 2;Cold-inducible RNA-binding protein;RNA-binding protein 39;116 kDa U5 small nuclear ribonucleoprotein component;RNA-binding protein with serine-rich domain 1;Poly(rC)-binding protein 1;Splicing factor 3B subunit 3;Splicing factor 3B subunit 4;Splicing factor 3A subunit 2;Splicing factor 3A subunit 1;Splicing factor 1;ELAV-like protein 1;Serine/arginine-rich splicing factor 7;Pre-mRNA-processing-splicing factor 8;Probable ATP-dependent RNA helicase DDX46;PHD finger-like domain-containing protein 5A;Zinc finger CCCH domain-containing protein 18;ATP-dependent RNA helicase DDX42;Calcium homeostasis endoplasmic reticulum protein;SURP and G-patch domain-containing protein 1;Cell division cycle and apoptosis regulator protein 1;Serine/arginine repetitive matrix protein 1;Cell cycle and apoptosis regulator protein 2;Angiogenic factor with G patch and FHA domains 1;Beta-catenin-like protein 1;Proline-rich protein PRCC;Probable ATP-dependent RNA helicase DDX17;Splicing factor 45;Cell division cycle 5-like protein;Heterogeneous nuclear ribonucleoprotein A/B;Telomerase RNA component interacting RNase;Nuclear receptor-interacting protein 2;Heterogeneous nuclear ribonucleoprotein U-like protein 1;Probable ATP-dependent RNA helicase DDX23;Splicing factor 3B subunit 5;Serrate RNA effector molecule homolog;Pinin;Protein transport protein Sec31B;Spliceosome-associated protein CWC15 homolog;SAP30-binding protein;Poly(U)-binding-splicing factor PUF60;Apoptotic chromatin condensation inducer in the nucleus;Pre-mRNA-processing factor 19;Serine/arginine repetitive matrix protein 2;Cyclin-dependent kinase 11A;WW domain-binding protein 11;Splicing factor 3B subunit 6;Cilia- and flagella-associated protein 20	FLJ10154;TCERG1;U2SURP;DHX15;SART1;HNRNPR;PRPF3;PLRG1;ZNF207;BUB3;HTATSF1;SYNCRIP;PQBP1;PRPF40A;SF3B1;SNRNP200;BCAS2;DNAJC8;SMNDC1;PRPF6;CD2BP2;HNRNPC;SNRPB2;SNRNP70;SNRPA;SNRPC;HNRNPA1;SNRPA1;HSPA8;SNRPB;DDX5;HNRNPA2B1;U2AF2;FUS;RBMX;RBM25;HNRNPA3;NCBP2;RBM5;HNRNPK;PPP1CA;SNRPE;SNRPF;SNRPG;SNRPD1;SNRPD2;SNRPD3;TRA2B;YBX1;SRSF3;RBM10;HNRNPU;U2AF1;SRSF2;SRSF1;SRSF4;DHX9;NCBP1;SF3A3;ILF2;ILF3;PPP1R8;SRSF9;SRSF5;SRSF6;SF3B2;CIRBP;RBM39;EFTUD2;RNPS1;PCBP1;SF3B3;SF3B4;SF3A2;SF3A1;SF1;ELAVL1;SRSF7;PRPF8;DDX46;PHF5A;ZC3H18;DDX42;CHERP;SUGP1;CCAR1;SRRM1;CCAR2;AGGF1;CTNNBL1;PRCC;DDX17;RBM17;CDC5L;HNRNPAB;TRIR;NRIP2;HNRNPUL1;DDX23;SF3B5;SRRT;PNN;SEC31B;CWC15;SAP30BP;PUF60;ACIN1;PRPF19;SRRM2;CDK11A;WBP11;SF3B6;CFAP20	None;CA150 TAF2S;KIAA0332 SR140;DBP1 DDX15;None;HNRPR;HPRP3 PRP3;None;BUGZ;None;None;HNRPQ NSAP1;NPW38;FBP11 FLAF1 FNBP3 HIP10 HYPA;SAP155;ASCC3L1 HELIC2 KIAA0788;DAM1;SPF31;SMNR SPF30;C20orf14;KIAA1178;HNRPC;None;RNPU1Z RPU1 SNRP70 U1AP1;None;None;HNRPA1;None;HSC70 HSP73 HSPA10;COD SNRPB1;G17P1 HELR HLR1;HNRPA2B1;U2AF65;TLS;HNRPG RBMXP1;RNPC7;HNRPA3;CBP20;None;HNRPK;PPP1A;None;PBSCF;PBSCG;None;SNRPD1;None;SFRS10;NSEP1 YB1;SFRS3 SRP20;DXS8237E GPATC9 GPATCH9 KIAA0122;C1orf199 HNRPU SAFA U21.1;U2AF35 U2AFBP;SFRS2;ASF SF2 SF2P33 SFRS1;SFRS4 SRP75;DDX9 LKP NDH2;CBP80 NCBP;SAP61;NF45;DRBF MPHOSPH4 NF90;ARD1 NIPP1;SFRS9 SRP30C;HRS SFRS5 SRP40;SFRS6, SRP55;SAP145;A18HNRNP CIRP;HCC1 RNPC2;KIAA0031 SNRP116;LDC2;None;KIAA0017 SAP130;SAP49;SAP62;SAP114;ZFM1 ZNF162;HUR;SFRS7;PRPC8;KIAA0801;None;NHN1;None;DAN26 SCAF6;SF4;CARP1 DIS;SRM160;DBC1 KIAA1967;GPATC7 GPATCH7 VG5Q;C20orf33;TPRC;None;SPF45;KIAA0432 PCDC5RP;ABBP1,HNRPAB;C19orf43;None;E1BAP5 HNRPUL1;None;SF3B10;ARS2 ASR2;DRS MEMA;SEC31L2;C11orf5;HCNGP HTRG HTRP;FIR ROBPI SIAHBP1;ACINUS KIAA0670;NMP200 PRP19 SNEV;KIAA0324 SRL300 SRM300;CDC2L2 CDC2L3 PITSLREB;NPWBP SIPP1 SNP70;SAP14 SF3B14 SF3B14A;BUG22 C16orf80 GTL3
8375	PRC1.1a complex	Human	None	293T-REx cells	Q06587;Q8N488;Q99496;Q9BSM1	6015;23429;6045;84759	MI:0029-cosedimentation through density gradient;MI:0676-tandem affinity purification	GO:0006355;GO:0035102	regulation of DNA-templated transcription;PRC1 complex	11.02.03.04	transcriptional control	22325352	PCGF1 target genes were enriched for gene ontology (GO) terms including cell junction organization and striated muscle-cell differentiation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase RING1;RING1 and YY1-binding protein;E3 ubiquitin-protein ligase RING2;Polycomb group RING finger protein 1	RING1;RYBP;RNF2;PCGF1	RNF1;DEDAF YEAF1;BAP1 DING HIPI3 RING1B;NSPC1 RNF68
8376	PRC1.1b complex	Human	None	293T-REx cells	Q06587;Q8IY57;Q99496;Q9BSM1	6015;10138;6045;84759	MI:0029-cosedimentation through density gradient;MI:0676-tandem affinity purification	GO:0006355;GO:0035102	regulation of DNA-templated transcription;PRC1 complex	11.02.03.04	transcriptional control	22325352	PCGF1 target genes were enriched for gene ontology (GO) terms including cell junction organization and striated muscle-cell differentiation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase RING1;YY1-associated factor 2;E3 ubiquitin-protein ligase RING2;Polycomb group RING finger protein 1	RING1;YAF2;RNF2;PCGF1	RNF1;None;BAP1 DING HIPI3 RING1B;NSPC1 RNF68
8377	PRC1.1c complex	Human	None	293T-REx cells	P63208;Q06587;Q5H9F3;Q6W2J9;Q8N488;Q8NHM5;Q93009;Q99496;Q9BSM1	6500;6015;63035;54880;23429;84678;7874;6045;84759	MI:0029-cosedimentation through density gradient;MI:0676-tandem affinity purification	GO:0006355;GO:0035102	regulation of DNA-templated transcription;PRC1 complex	11.02.03.04	transcriptional control	22325352	PCGF1 target genes were enriched for gene ontology (GO) terms including cell junction organization and striated muscle-cell differentiation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	S-phase kinase-associated protein 1;E3 ubiquitin-protein ligase RING1;BCL-6 corepressor-like protein 1;BCL-6 corepressor;RING1 and YY1-binding protein;Lysine-specific demethylase 2B;Ubiquitin carboxyl-terminal hydrolase 7;E3 ubiquitin-protein ligase RING2;Polycomb group RING finger protein 1	SKP1;RING1;BCORL1;BCOR;RYBP;KDM2B;USP7;RNF2;PCGF1	EMC19 OCP2 SKP1A TCEB1L;RNF1;None;KIAA1575;DEDAF YEAF1;CXXC2 FBL10 FBXL10 JHDM1B NDY1 PCCX2;HAUSP;BAP1 DING HIPI3 RING1B;NSPC1 RNF68
8378	PRC1.1d complex	Human	None	293T-REx cells	P63208;Q06587;Q5H9F3;Q6W2J9;Q8IY57;Q8NHM5;Q93009;Q99496;Q9BSM1	6500;6015;63035;54880;10138;84678;7874;6045;84759	MI:0029-cosedimentation through density gradient;MI:0676-tandem affinity purification	GO:0006355;GO:0035102	regulation of DNA-templated transcription;PRC1 complex	11.02.03.04	transcriptional control	22325352	PCGF1 target genes were enriched for gene ontology (GO) terms including cell junction organization and striated muscle-cell differentiation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	S-phase kinase-associated protein 1;E3 ubiquitin-protein ligase RING1;BCL-6 corepressor-like protein 1;BCL-6 corepressor;YY1-associated factor 2;Lysine-specific demethylase 2B;Ubiquitin carboxyl-terminal hydrolase 7;E3 ubiquitin-protein ligase RING2;Polycomb group RING finger protein 1	SKP1;RING1;BCORL1;BCOR;YAF2;KDM2B;USP7;RNF2;PCGF1	EMC19 OCP2 SKP1A TCEB1L;RNF1;None;KIAA1575;None;CXXC2 FBL10 FBXL10 JHDM1B NDY1 PCCX2;HAUSP;BAP1 DING HIPI3 RING1B;NSPC1 RNF68
8379	PRC1.2a complex	Human	None	293T-REx cells	P35227;Q06587;Q8N488;Q99496	7703;6015;23429;6045	MI:0029-cosedimentation through density gradient;MI:0676-tandem affinity purification	GO:0006355;GO:0035102	regulation of DNA-templated transcription;PRC1 complex	11.02.03.04	transcriptional control	22325352	PCGF2 target genes were enriched for Gene Ontology terms such as epithelial cell differentiation and embryonic pattern specification.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Polycomb group RING finger protein 2;E3 ubiquitin-protein ligase RING1;RING1 and YY1-binding protein;E3 ubiquitin-protein ligase RING2	PCGF2;RING1;RYBP;RNF2	MEL18 RNF110 ZNF144;RNF1;DEDAF YEAF1;BAP1 DING HIPI3 RING1B
8380	PRC1.2b complex	Human	None	293T-REx cells	P35227;Q06587;Q8IY57;Q99496	7703;6015;10138;6045	MI:0029-cosedimentation through density gradient;MI:0676-tandem affinity purification	GO:0006355;GO:0035102	regulation of DNA-templated transcription;PRC1 complex	11.02.03.04	transcriptional control	22325352	PCGF2 target genes were enriched for Gene Ontology terms such as epithelial cell differentiation and embryonic pattern specification.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Polycomb group RING finger protein 2;E3 ubiquitin-protein ligase RING1;YY1-associated factor 2;E3 ubiquitin-protein ligase RING2	PCGF2;RING1;YAF2;RNF2	MEL18 RNF110 ZNF144;RNF1;None;BAP1 DING HIPI3 RING1B
8381	PRC1.2c complex	Human	None	293T-REx cells	O00257;P35227;P78364;Q06587;Q14781;Q8IXK0;Q8NDX5;Q96GD3;Q99496;Q9HC52;Q9UN30	8535;7703;1911;6015;84733;1912;80012;22955;6045;57332;6322	MI:0029-cosedimentation through density gradient;MI:0676-tandem affinity purification	GO:0006355;GO:0035102	regulation of DNA-templated transcription;PRC1 complex	11.02.03.04	transcriptional control	22325352	PCGF2 target genes were enriched for Gene Ontology terms such as epithelial cell differentiation and embryonic pattern specification.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 SUMO-protein ligase CBX4;Polycomb group RING finger protein 2;Polyhomeotic-like protein 1;E3 ubiquitin-protein ligase RING1;Chromobox protein homolog 2;Polyhomeotic-like protein 2;Polyhomeotic-like protein 3;Polycomb protein SCMH1;E3 ubiquitin-protein ligase RING2;Chromobox protein homolog 8;Sex comb on midleg-like protein 1	CBX4;PCGF2;PHC1;RING1;CBX2;PHC2;PHC3;SCMH1;RNF2;CBX8;SCML1	None;MEL18 RNF110 ZNF144;EDR1 PH1;RNF1;None;EDR2 PH2;EDR3 PH3;None;BAP1 DING HIPI3 RING1B;PC3 RC1;None
8382	PRC1.3a complex	Human	None	293T-REx cells	P19784;P67870;P68400;Q06587;Q3KNV8;Q8N488;Q8WXX7;Q99496;Q9HAH7;Q9HCM7	1459;1460;1457;6015;10336;23429;26053;6045;64319;57666	MI:0029-cosedimentation through density gradient;MI:0676-tandem affinity purification	GO:0006355;GO:0035102	regulation of DNA-templated transcription;PRC1 complex	11.02.03.04	transcriptional control	22325352	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Casein kinase II subunit alpha';Casein kinase II subunit beta;Casein kinase II subunit alpha;E3 ubiquitin-protein ligase RING1;Polycomb group RING finger protein 3;RING1 and YY1-binding protein;Autism susceptibility gene 2 protein;E3 ubiquitin-protein ligase RING2;Probable fibrosin-1;Fibrosin-1-like protein	CSNK2A2;CSNK2B;CSNK2A1;RING1;PCGF3;RYBP;AUTS2;RNF2;FBRS;FBRSL1	CK2A2;CK2N G5A;CK2A1;RNF1;RNF3,RNF3A;DEDAF YEAF1;KIAA0442;BAP1 DING HIPI3 RING1B;FBS,FBS1;AUTS2L KIAA1545 XTP9
8383	PRC1.3b complex	Human	None	293T-REx cells	P19784;P67870;P68400;Q06587;Q3KNV8;Q8IY57;Q8WXX7;Q99496;Q9HAH7;Q9HCM7	1459;1460;1457;6015;10336;10138;26053;6045;64319;57666	MI:0029-cosedimentation through density gradient;MI:0676-tandem affinity purification	GO:0006355;GO:0035102	regulation of DNA-templated transcription;PRC1 complex	11.02.03.04	transcriptional control	22325352	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Casein kinase II subunit alpha';Casein kinase II subunit beta;Casein kinase II subunit alpha;E3 ubiquitin-protein ligase RING1;Polycomb group RING finger protein 3;YY1-associated factor 2;Autism susceptibility gene 2 protein;E3 ubiquitin-protein ligase RING2;Probable fibrosin-1;Fibrosin-1-like protein	CSNK2A2;CSNK2B;CSNK2A1;RING1;PCGF3;YAF2;AUTS2;RNF2;FBRS;FBRSL1	CK2A2;CK2N G5A;CK2A1;RNF1;RNF3,RNF3A;None;KIAA0442;BAP1 DING HIPI3 RING1B;FBS,FBS1;AUTS2L KIAA1545 XTP9
8384	PRC1.4a complex	Human	None	293T-REx cells	P35226;Q06587;Q8N488;Q99496	648;6015;23429;6045	MI:0029-cosedimentation through density gradient;MI:0676-tandem affinity purification	GO:0006355;GO:0035102	regulation of DNA-templated transcription;PRC1 complex	11.02.03.04	transcriptional control	22325352	PCGF4 target genes were enriched for Gene Ontology terms related with translation and metabolism.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Polycomb complex protein BMI-1;E3 ubiquitin-protein ligase RING1;RING1 and YY1-binding protein;E3 ubiquitin-protein ligase RING2	BMI1;RING1;RYBP;RNF2	PCGF4 RNF51;RNF1;DEDAF YEAF1;BAP1 DING HIPI3 RING1B
8385	PRC1.4b complex	Human	None	293T-REx cells	P35226;Q06587;Q8IY57;Q99496	648;6015;10138;6045	MI:0029-cosedimentation through density gradient;MI:0676-tandem affinity purification	GO:0006355;GO:0035102	regulation of DNA-templated transcription;PRC1 complex	11.02.03.04	transcriptional control	22325352	PCGF4 target genes were enriched for Gene Ontology terms related with translation and metabolism.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Polycomb complex protein BMI-1;E3 ubiquitin-protein ligase RING1;YY1-associated factor 2;E3 ubiquitin-protein ligase RING2	BMI1;RING1;YAF2;RNF2	PCGF4 RNF51;RNF1;None;BAP1 DING HIPI3 RING1B
8386	PRC1.4c complex	Human	None	293T-REx cells	O00257;O95503;P35226;P78364;Q06587;Q14781;Q8IXK0;Q8NDX5;Q96GD3;Q99496;Q9HC52	8535;23466;648;1911;6015;84733;1912;80012;22955;6045;57332	MI:0029-cosedimentation through density gradient;MI:0676-tandem affinity purification	GO:0006355;GO:0035102	regulation of DNA-templated transcription;PRC1 complex	11.02.03.04	transcriptional control	22325352	PCGF4 target genes were enriched for Gene Ontology terms related with translation and metabolism.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 SUMO-protein ligase CBX4;Chromobox protein homolog 6;Polycomb complex protein BMI-1;Polyhomeotic-like protein 1;E3 ubiquitin-protein ligase RING1;Chromobox protein homolog 2;Polyhomeotic-like protein 2;Polyhomeotic-like protein 3;Polycomb protein SCMH1;E3 ubiquitin-protein ligase RING2;Chromobox protein homolog 8	CBX4;CBX6;BMI1;PHC1;RING1;CBX2;PHC2;PHC3;SCMH1;RNF2;CBX8	None;None;PCGF4 RNF51;EDR1 PH1;RNF1;None;EDR2 PH2;EDR3 PH3;None;BAP1 DING HIPI3 RING1B;PC3 RC1
8387	PRC1.5a complex	Human	None	293T-REx cells	P19784;P67870;P68400;Q06587;Q86SE9;Q8N488;Q8WXX7;Q99496;Q9HAH7;Q9HCM7	1459;1460;1457;6015;84333;23429;26053;6045;64319;57666	MI:0029-cosedimentation through density gradient;MI:0676-tandem affinity purification	GO:0006355;GO:0035102	regulation of DNA-templated transcription;PRC1 complex	11.02.03.04	transcriptional control	22325352	PCGF5 target genes were related with phenotypes like decreased startle reflex and abnormal muscle relaxation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Casein kinase II subunit alpha';Casein kinase II subunit beta;Casein kinase II subunit alpha;E3 ubiquitin-protein ligase RING1;Polycomb group RING finger protein 5;RING1 and YY1-binding protein;Autism susceptibility gene 2 protein;E3 ubiquitin-protein ligase RING2;Probable fibrosin-1;Fibrosin-1-like protein	CSNK2A2;CSNK2B;CSNK2A1;RING1;PCGF5;RYBP;AUTS2;RNF2;FBRS;FBRSL1	CK2A2;CK2N G5A;CK2A1;RNF1;RNF159;DEDAF YEAF1;KIAA0442;BAP1 DING HIPI3 RING1B;FBS,FBS1;AUTS2L KIAA1545 XTP9
8388	PRC1.5c	Human	None	293T-REx cells	P19784;P67870;P68400;Q06587;Q86SE9;Q8IY57;Q8WXX7;Q99496;Q9HAH7;Q9HCM7	1459;1460;1457;6015;84333;10138;26053;6045;64319;57666	MI:0029-cosedimentation through density gradient;MI:0676-tandem affinity purification	GO:0006355;GO:0035102	regulation of DNA-templated transcription;PRC1 complex	11.02.03.04	transcriptional control	22325352	PCGF5 target genes were related with phenotypes like decreased startle reflex and abnormal muscle relaxation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Casein kinase II subunit alpha';Casein kinase II subunit beta;Casein kinase II subunit alpha;E3 ubiquitin-protein ligase RING1;Polycomb group RING finger protein 5;YY1-associated factor 2;Autism susceptibility gene 2 protein;E3 ubiquitin-protein ligase RING2;Probable fibrosin-1;Fibrosin-1-like protein	CSNK2A2;CSNK2B;CSNK2A1;RING1;PCGF5;YAF2;AUTS2;RNF2;FBRS;FBRSL1	CK2A2;CK2N G5A;CK2A1;RNF1;RNF159;None;KIAA0442;BAP1 DING HIPI3 RING1B;FBS,FBS1;AUTS2L KIAA1545 XTP9
8389	PRC1.6a complex	Human	None	293T-REx cells	O75461;P61244;P61964;Q06587;Q13185;Q13547;Q14186;Q8IWI9;Q8N488;Q92769;Q969R5;Q99496;Q9BYE7	1876;4149;11091;6015;11335;3065;7027;23269;23429;3066;83746;6045;84108	MI:0029-cosedimentation through density gradient;MI:0676-tandem affinity purification	GO:0006355;GO:0035102	regulation of DNA-templated transcription;PRC1 complex	11.02.03.04	transcriptional control	22325352	PCGF6 target genes were enriched for phenotype like abnormal vaginal opening/morphology in mice.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transcription factor E2F6;Protein max;WD repeat-containing protein 5;E3 ubiquitin-protein ligase RING1;Chromobox protein homolog 3;Histone deacetylase 1;Transcription factor Dp-1;MAX gene-associated protein;RING1 and YY1-binding protein;Histone deacetylase 2;Lethal(3)malignant brain tumor-like protein 2;E3 ubiquitin-protein ligase RING2;Polycomb group RING finger protein 6	E2F6;MAX;WDR5;RING1;CBX3;HDAC1;TFDP1;MGA;RYBP;HDAC2;L3MBTL2;RNF2;PCGF6	None;BHLHD4;BIG3;RNF1;None;RPD3L1;DP1;KIAA0518 MAD5;DEDAF YEAF1;None;None;BAP1 DING HIPI3 RING1B;MBLR RNF134
8390	PRC1.6b complex	Human	None	293T-REx cells	O75461;P61244;P61964;Q06587;Q13185;Q13547;Q14186;Q8IWI9;Q8IY57;Q92769;Q969R5;Q99496;Q9BYE7	1876;4149;11091;6015;11335;3065;7027;23269;10138;3066;83746;6045;84108	MI:0029-cosedimentation through density gradient;MI:0676-tandem affinity purification	GO:0006355;GO:0035102	regulation of DNA-templated transcription;PRC1 complex	11.02.03.04	transcriptional control	22325352	PCGF6 target genes were enriched for phenotype like abnormal vaginal opening/morphology in mice.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transcription factor E2F6;Protein max;WD repeat-containing protein 5;E3 ubiquitin-protein ligase RING1;Chromobox protein homolog 3;Histone deacetylase 1;Transcription factor Dp-1;MAX gene-associated protein;YY1-associated factor 2;Histone deacetylase 2;Lethal(3)malignant brain tumor-like protein 2;E3 ubiquitin-protein ligase RING2;Polycomb group RING finger protein 6	E2F6;MAX;WDR5;RING1;CBX3;HDAC1;TFDP1;MGA;YAF2;HDAC2;L3MBTL2;RNF2;PCGF6	None;BHLHD4;BIG3;RNF1;None;RPD3L1;DP1;KIAA0518 MAD5;None;None;None;BAP1 DING HIPI3 RING1B;MBLR RNF134
8391	Spliceosome, E complex	Human	None	HeLa cells	O00148;O14497;O14893;O15042;O43143;O43172;O43290;O43390;O43395;O43447;O43719;O43809;O60506;O75400;O75526;O75533;O75643;O75934;O75937;O94906;O95104;O95232;O96019;P07910;P08579;P08621;P09012;P09234;P09651;P09661;P14678;P14866;P17844;P22626;P26368;P28370;P31943;P35637;P42285;P49756;P51531;P51532;P52272;P52298;P52597;P57678;P61978;P62304;P62306;P62308;P62314;P62316;P62318;P67809;P84103;P98175;Q00839;Q01081;Q01130;Q05519;Q07955;Q08170;Q08211;Q09161;Q10570;Q12824;Q12872;Q12874;Q13151;Q13243;Q13247;Q13435;Q13838;Q14103;Q14498;Q14839;Q15020;Q15029;Q15365;Q15366;Q15393;Q15427;Q15428;Q15459;Q15637;Q16629;Q16630;Q16637;Q53GS9;Q562R1;Q68CP9;Q6NZY4;Q6P2Q9;Q7L014;Q7RTV0;Q86U86;Q86V81;Q8IWX8;Q8N684;Q8NFD5;Q8TAQ2;Q8TEQ6;Q8WWY3;Q8WXA9;Q8WXD5;Q92841;Q92922;Q92945;Q969G3;Q96DI7;Q96GM5;Q96I25;Q9BRL6;Q9BTD8;Q9BUQ8;Q9BXP5;Q9HCK8;Q9NWZ8;Q9UHI6;Q9UHX1;Q9UMS4;Q9UQ35;Q9Y230;Q9Y265;Q9Y383;Q9Y3B4;Q9Y3F4;Q9Y4Z0;Q9Y580	10212;8289;8487;23350;1665;9128;9092;10236;9129;10465;27336;11051;10492;55660;27288;23451;23020;10286;22826;24148;57466;51747;86;3183;6629;6625;6626;6631;3178;6627;6628;3191;1655;3181;11338;6594;3187;2521;23517;58517;6595;6597;4670;22916;3185;50628;3190;6635;6636;6637;6632;6633;6634;4904;6428;8241;3192;7307;6427;9295;6426;6429;1660;4686;29894;6598;6433;10946;10949;6430;6431;10992;7919;3184;9584;1108;9733;9343;5093;5094;23450;10262;8175;10291;7536;6432;11052;None;10713;345651;196528;55596;10594;9879;84844;55193;10189;10523;79869;57492;6601;25929;26121;140890;79833;10521;6599;8570;6605;9410;6602;84991;10929;79171;9416;51593;57680;54960;11218;22827;27339;23524;10856;8607;51631;51639;11171;25804;10179	MI:0029-cosedimentation through density gradient;MI:0096-pull down	GO:0000398;GO:0005681	mRNA splicing, via spliceosome;spliceosomal complex	11.04.03	mRNA processing (splicing, 5'-, 3'-end processing)	22110043	Spliceosomes assemble in a series of consecutive steps that produce complexes E, A, B and C. First, in the E complex, the 5' - and 3' -splice sites of an intron are recognized by the specific binding of the U1 snRNP and the proteins U2 auxiliary factor (U2AF), respectively.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	ATP-dependent RNA helicase DDX39A;AT-rich interactive domain-containing protein 1A;Gem-associated protein 2;U2 snRNP-associated SURP motif-containing protein;ATP-dependent RNA helicase DHX15;U4/U6 small nuclear ribonucleoprotein Prp4;U4/U6.U5 tri-snRNP-associated protein 1;Heterogeneous nuclear ribonucleoprotein R;U4/U6 small nuclear ribonucleoprotein Prp3;Peptidyl-prolyl cis-trans isomerase H;HIV Tat-specific factor 1;Cleavage and polyadenylation specificity factor subunit 5;Heterogeneous nuclear ribonucleoprotein Q;Pre-mRNA-processing factor 40 homolog A;RNA-binding motif protein, X-linked-like-2;Splicing factor 3B subunit 1;U5 small nuclear ribonucleoprotein 200 kDa helicase;Pre-mRNA-splicing factor SPF27;DnaJ homolog subfamily C member 8;Pre-mRNA-processing factor 6;SR-related and CTD-associated factor 4;Luc7-like protein 3;Actin-like protein 6A;Heterogeneous nuclear ribonucleoproteins C1/C2;U2 small nuclear ribonucleoprotein B'';U1 small nuclear ribonucleoprotein 70 kDa;U1 small nuclear ribonucleoprotein A;U1 small nuclear ribonucleoprotein C;Heterogeneous nuclear ribonucleoprotein A1;U2 small nuclear ribonucleoprotein A';Small nuclear ribonucleoprotein-associated proteins B and B';Heterogeneous nuclear ribonucleoprotein L;Probable ATP-dependent RNA helicase DDX5;Heterogeneous nuclear ribonucleoproteins A2/B1;Splicing factor U2AF 65 kDa subunit;Probable global transcription activator SNF2L1;Heterogeneous nuclear ribonucleoprotein H;RNA-binding protein FUS;Exosome RNA helicase MTR4;RNA-binding protein 25;Probable global transcription activator SNF2L2;Transcription activator BRG1;Heterogeneous nuclear ribonucleoprotein M;Nuclear cap-binding protein subunit 2;Heterogeneous nuclear ribonucleoprotein F;Gem-associated protein 4;Heterogeneous nuclear ribonucleoprotein K;Small nuclear ribonucleoprotein E;Small nuclear ribonucleoprotein F;Small nuclear ribonucleoprotein G;Small nuclear ribonucleoprotein Sm D1;Small nuclear ribonucleoprotein Sm D2;Small nuclear ribonucleoprotein Sm D3;Y-box-binding protein 1;Serine/arginine-rich splicing factor 3;RNA-binding protein 10;Heterogeneous nuclear ribonucleoprotein U;Splicing factor U2AF 35 kDa subunit;Serine/arginine-rich splicing factor 2;Serine/arginine-rich splicing factor 11;Serine/arginine-rich splicing factor 1;Serine/arginine-rich splicing factor 4;ATP-dependent RNA helicase A;Nuclear cap-binding protein subunit 1;Cleavage and polyadenylation specificity factor subunit 1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1;Splicing factor, suppressor of white-apricot homolog;Splicing factor 3A subunit 3;Heterogeneous nuclear ribonucleoprotein A0;Serine/arginine-rich splicing factor 5;Serine/arginine-rich splicing factor 6;Splicing factor 3B subunit 2;Spliceosome RNA helicase DDX39B;Heterogeneous nuclear ribonucleoprotein D0;RNA-binding protein 39;Chromodomain-helicase-DNA-binding protein 4;Squamous cell carcinoma antigen recognized by T-cells 3;116 kDa U5 small nuclear ribonucleoprotein component;Poly(rC)-binding protein 1;Poly(rC)-binding protein 2;Splicing factor 3B subunit 3;Splicing factor 3B subunit 4;Splicing factor 3A subunit 2;Splicing factor 3A subunit 1;Splicing factor 1;Serine/arginine-rich splicing factor 7;Cleavage and polyadenylation specificity factor subunit 6;Survival motor neuron protein;U4/U6.U5 tri-snRNP-associated protein 2;Beta-actin-like protein 2;AT-rich interactive domain-containing protein 2;Zinc finger CCHC domain-containing protein 8;Pre-mRNA-processing-splicing factor 8;Probable ATP-dependent RNA helicase DDX46;PHD finger-like domain-containing protein 5A;Protein polybromo-1;THO complex subunit 4;Calcium homeostasis endoplasmic reticulum protein;Cleavage and polyadenylation specificity factor subunit 7;AT-rich interactive domain-containing protein 1B;SWI/SNF complex subunit SMARCC2;Gem-associated protein 5;U4/U6 small nuclear ribonucleoprotein Prp31;Splicing regulatory glutamine/lysine-rich protein 1;Gem-associated protein 6;Probable ATP-dependent RNA helicase DDX17;SWI/SNF complex subunit SMARCC1;Far upstream element-binding protein 2;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1;U5 small nuclear ribonucleoprotein 40 kDa protein;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1;Splicing factor 45;Serine/arginine-rich splicing factor 8;RNA-binding protein 42;Probable ATP-dependent RNA helicase DDX23;Serrate RNA effector molecule homolog;Chromodomain-helicase-DNA-binding protein 8;Gem-associated protein 8;Probable ATP-dependent RNA helicase DDX20;Poly(U)-binding-splicing factor PUF60;Pre-mRNA-processing factor 19;Serine/arginine repetitive matrix protein 2;RuvB-like 2;RuvB-like 1;Putative RNA-binding protein Luc7-like 2;Splicing factor 3B subunit 6;Serine-threonine kinase receptor-associated protein;U6 snRNA-associated Sm-like protein LSm4;RNA-binding protein 7	DDX39A;ARID1A;GEMIN2;U2SURP;DHX15;PRPF4;SART1;HNRNPR;PRPF3;PPIH;HTATSF1;NUDT21;SYNCRIP;PRPF40A;RBMXL2;SF3B1;SNRNP200;BCAS2;DNAJC8;PRPF6;SCAF4;LUC7L3;ACTL6A;HNRNPC;SNRPB2;SNRNP70;SNRPA;SNRPC;HNRNPA1;SNRPA1;SNRPB;HNRNPL;DDX5;HNRNPA2B1;U2AF2;SMARCA1;HNRNPH1;FUS;MTREX;RBM25;SMARCA2;SMARCA4;HNRNPM;NCBP2;HNRNPF;GEMIN4;HNRNPK;SNRPE;SNRPF;SNRPG;SNRPD1;SNRPD2;SNRPD3;YBX1;SRSF3;RBM10;HNRNPU;U2AF1;SRSF2;SRSF11;SRSF1;SRSF4;DHX9;NCBP1;CPSF1;SMARCB1;SFSWAP;SF3A3;HNRNPA0;SRSF5;SRSF6;SF3B2;DDX39B;HNRNPD;RBM39;CHD4;SART3;EFTUD2;PCBP1;PCBP2;SF3B3;SF3B4;SF3A2;SF3A1;SF1;SRSF7;CPSF6;SMN1;USP39;ACTBL2;ARID2;ZCCHC8;PRPF8;DDX46;PHF5A;PBRM1;ALYREF;CHERP;CPSF7;ARID1B;SMARCC2;GEMIN5;PRPF31;SREK1;GEMIN6;DDX17;SMARCC1;KHSRP;SMARCE1;SNRNP40;SMARCD1;RBM17;SRSF8;RBM42;DDX23;SRRT;CHD8;GEMIN8;DDX20;PUF60;PRPF19;SRRM2;RUVBL2;RUVBL1;LUC7L2;SF3B6;STRAP;LSM4;RBM7	DDX39;BAF250 BAF250A C1orf4 OSA1 SMARCF1;SIP1;KIAA0332 SR140;DBP1 DDX15;PRP4;None;HNRPR;HPRP3 PRP3;CYP20 CYPH;None;CFIM25 CPSF25 CPSF5;HNRPQ NSAP1;FBP11 FLAF1 FNBP3 HIP10 HYPA;HNRNPGT;SAP155;ASCC3L1 HELIC2 KIAA0788;DAM1;SPF31;C20orf14;KIAA1172 SFRS15;CREAP1 CROP O48;BAF53 BAF53A INO80K;HNRPC;None;RNPU1Z RPU1 SNRP70 U1AP1;None;None;HNRPA1;None;COD SNRPB1;HNRPL;G17P1 HELR HLR1;HNRPA2B1;U2AF65;SNF2L SNF2L1;HNRPH HNRPH1;TLS;DOB1 KIAA0052 MTR4 SKIV2L2;RNPC7;BAF190B BRM SNF2A SNF2L2;BAF190A BRG1 SNF2B SNF2L4;HNRPM NAGR1;CBP20;HNRPF;None;HNRPK;None;PBSCF;PBSCG;None;SNRPD1;None;NSEP1 YB1;SFRS3 SRP20;DXS8237E GPATC9 GPATCH9 KIAA0122;C1orf199 HNRPU SAFA U21.1;U2AF35 U2AFBP;SFRS2;SFRS11;ASF SF2 SF2P33 SFRS1;SFRS4 SRP75;DDX9 LKP NDH2;CBP80 NCBP;CPSF160;BAF47, INI1, SNF5L1;SFRS8,SWAP;SAP61;HNRPA0;HRS SFRS5 SRP40;SFRS6, SRP55;SAP145;BAT1 UAP56;AUF1 HNRPD;HCC1 RNPC2;None;KIAA0156 TIP110;KIAA0031 SNRP116;None;None;KIAA0017 SAP130;SAP49;SAP62;SAP114;ZFM1 ZNF162;SFRS7;CFIM68;SMN SMNT;None;None;BAF200 KIAA1557;None;PRPC8;KIAA0801;None;BAF180 PB1;ALY BEF THOC4;DAN26 SCAF6;None;BAF250B DAN15 KIAA1235 OSA2;BAF170;None;PRP31;SFRS12 SRRP86;None;None;BAF155;FUBP2;BAF57;PRP8BP SFP38 WDR57;BAF60A;SPF45;SFRS2B SRP46;None;None;ARS2 ASR2;HELSNF1 KIAA1564;FAM51A1;DP103 GEMIN3;FIR ROBPI SIAHBP1;NMP200 PRP19 SNEV;KIAA0324 SRL300 SRM300;INO80J TIP48 TIP49B;INO80H NMP238 TIP49 TIP49A;None;SAP14 SF3B14 SF3B14A;MAWD UNRIP;None;None
8393	GNB5-GPR158-RGS7 complex	Human	None	HEK293T/17 cells	O14775;P49802;Q5T848	10681;6000;57512	MI:0007-anti tag coimmunoprecipitation	GO:0007186;GO:0005886	G protein-coupled receptor signaling pathway;plasma membrane	30.05.02.24;70.02	G-protein coupled receptor signalling pathway;eukaryotic plasma membrane / membrane attached	22689652	Results suggest that GPR158 serves as a membrane anchor for the GNB5-RGS7 complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein subunit beta-5;Regulator of G-protein signaling 7;Probable G-protein coupled receptor 158	GNB5;RGS7;GPR158	None;None;KIAA1136
8394	GNB5-GPR158-RGS6 complex	Human	None	HEK293T/17 cells	O14775;P49758;Q5T848	10681;9628;57512	MI:0007-anti tag coimmunoprecipitation	GO:0007186	G protein-coupled receptor signaling pathway	30.05.02.24	G-protein coupled receptor signalling pathway	22689652	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein subunit beta-5;Regulator of G-protein signaling 6;Probable G-protein coupled receptor 158	GNB5;RGS6;GPR158	None;None;KIAA1136
8395	GNB5-RGS7-RGS7BP complex	Human	None	HEK293T/17 cells	O14775;P49802;Q6MZT1	10681;6000;401190	MI:0007-anti tag coimmunoprecipitation	GO:0007186;GO:0005886	G protein-coupled receptor signaling pathway;plasma membrane	30.05.02.24;70.02	G-protein coupled receptor signalling pathway;eukaryotic plasma membrane / membrane attached	22689652	In competi\u00adtion experiments, the binding of R7BP and GPR158 to GNB5-RGS7 was found to be mutually exclusive.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein subunit beta-5;Regulator of G-protein signaling 7;Regulator of G-protein signaling 7-binding protein	GNB5;RGS7;RGS7BP	None;None;R7BP
8396	GNB5-GPR179-RGS6 complex	Human	None	HEK293T/17 cells	O14775;P49758;Q6PRD1	10681;9628;440435	MI:0007-anti tag coimmunoprecipitation	GO:0007186;GO:0005886;GO:1990603	G protein-coupled receptor signaling pathway;plasma membrane;dark adaptation	30.05.02.24;70.02	G-protein coupled receptor signalling pathway;eukaryotic plasma membrane / membrane attached	22689652	Data suggest that GPR179 is essential for the postsynaptic targeting of the RGS\u2013GNB5 complexes in retinal ON bipolar neurons.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein subunit beta-5;Regulator of G-protein signaling 6;Probable G-protein coupled receptor 179	GNB5;RGS6;GPR179	None;None;GPR158L,GPR158L1
8397	GNB5-GPR179-RGS7 complex	Human	None	HEK293T/17 cells	O14775;P49802;Q6PRD1	10681;6000;440435	MI:0007-anti tag coimmunoprecipitation	GO:0007186;GO:0005886;GO:1990603	G protein-coupled receptor signaling pathway;plasma membrane;dark adaptation	30.05.02.24;70.02	G-protein coupled receptor signalling pathway;eukaryotic plasma membrane / membrane attached	22689652	Experiments revealed that RGS7 and RGS11 colocalize with GPR179 at the dendritic tips of the ON bipolar cells.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein subunit beta-5;Regulator of G-protein signaling 7;Probable G-protein coupled receptor 179	GNB5;RGS7;GPR179	None;None;GPR158L,GPR158L1
8398	GNB5-GPR179-RGS9 complex	Human	None	HEK293T/17 cells	O14775;O75916;Q6PRD1	10681;8787;440435	MI:0007-anti tag coimmunoprecipitation	GO:0007186;GO:0005886;GO:1990603	G protein-coupled receptor signaling pathway;plasma membrane;dark adaptation	30.05.02.24;70.02	G-protein coupled receptor signalling pathway;eukaryotic plasma membrane / membrane attached	22689652	Data suggest that GPR179 is essential for the postsynaptic targeting of the RGS-GNB5 complexes in retinal ON bipolar neurons.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein subunit beta-5;Regulator of G-protein signaling 9;Probable G-protein coupled receptor 179	GNB5;RGS9;GPR179	None;None;GPR158L,GPR158L1
8399	GNB5-GPR179-RGS11 complex	Human	None	HEK293T/17 cells	O14775;O94810;Q6PRD1	10681;8786;440435	MI:0007-anti tag coimmunoprecipitation	GO:0007186;GO:0005886;GO:1990603	G protein-coupled receptor signaling pathway;plasma membrane;dark adaptation	30.05.02.24;70.02	G-protein coupled receptor signalling pathway;eukaryotic plasma membrane / membrane attached	22689652	Experiments revealed that RGS7 and RGS11 colocalize with GPR179 at the dendritic tips of the ON bipolar cells.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanine nucleotide-binding protein subunit beta-5;Regulator of G-protein signaling 11;Probable G-protein coupled receptor 179	GNB5;RGS11;GPR179	None;None;GPR158L,GPR158L1
8402	MAP3K7-TAB2 complex	Human	TAB2-TAK1 complex	HEK293 cells; HeLa cells; Jurkat cell extract	O43318;Q9NYJ8	6885;23118	MI:0007-anti tag coimmunoprecipitation	GO:0043085;GO:0008047;GO:0006468	positive regulation of catalytic activity;enzyme activator activity;protein phosphorylation	18.02.01.01;14.07.03	enzyme activator;modification by phosphorylation, dephosphorylation, autophosphorylation	15125833	Poly-ubiquitination of NEMO may facilitate the recruitment of the IkappaB kinase complex to the TAK1/TAB2 complex, allowing TAK1 to phosphorylate IKKbeta in the activation loop thereby activating IKK.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Mitogen-activated protein kinase kinase kinase 7;TGF-beta-activated kinase 1 and MAP3K7-binding protein 2	MAP3K7;TAB2	TAK1;KIAA0733, MAP3K7IP2
8403	NAIP-CASP9 complex	Human	None	HeLa cells	P55211;Q13075	842;4671	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0089720;GO:0043008	caspase binding;ATP-dependent protein binding	None	None	15280366	The  ATP-induced  conformational change in NAIP that leads to interaction with caspase-9 is not accompanied by a change in the oligomeric structure of NAIP.	None	NAIP interaction with Caspase-9 is ATP-dependent.	Homo sapiens (Human);Homo sapiens (Human)	Caspase-9;Baculoviral IAP repeat-containing protein 1	CASP9;NAIP	MCH6;BIRC1
8405	GID/CTLH ubiquitin E3 ligase complex	Human	GID/CTLH complex (RMND5A)	HEK-293 cells	P62699;Q6VN20;Q7L5Y9;Q8IUR7;Q8IVV7;Q96S59;Q9H7D7;Q9H871;Q9NWU2;Q9UL63	51646;57610;10296;25852;79018;10048;80232;64795;54994;4289	MI:0007-anti tag coimmunoprecipitation;MI:0071-molecular sieving	GO:0010499;GO:0016567;GO:0000151;GO:0061630;GO:0001558	proteasomal ubiquitin-independent protein catabolic process;protein ubiquitination;ubiquitin ligase complex;ubiquitin protein ligase activity;regulation of cell growth	14.07.05	modification by ubiquitination, deubiquitination	29911972	The GID/CTLH ubiquitin E3 ligase complex promotes cell proliferation and targets the transcription factor HBP1 for degradation.	None	With a molecular weight of at least 550 kDa, the mammalian GID complex potentially constitutes an exceptionally large E3 ubiquitin ligase. The protein complex contains RMND5A or RMND5B as subunit.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein yippee-like 5;Ran-binding protein 10;E3 ubiquitin-protein transferase MAEA;Armadillo repeat-containing protein 8;Glucose-induced degradation protein 4 homolog;Ran-binding protein 9;WD repeat-containing protein 26;E3 ubiquitin-protein transferase RMND5A;Glucose-induced degradation protein 8 homolog;Muskelin	YPEL5;RANBP10;MAEA;ARMC8;GID4;RANBP9;WDR26;RMND5A;GID8;MKLN1	None;KIAA1464;EMP;None;C17orf39,VID24;RANBPM;CDW2 MIP2;None;C20orf11 TWA1;None
8406	GID/CTLH ubiquitin E3 ligase complex	Human	GID/CTLH complex (RMND5B)	HEK-293 cells	P62699;Q6VN20;Q7L5Y9;Q8IUR7;Q8IVV7;Q96G75;Q96S59;Q9H7D7;Q9NWU2;Q9UL63	51646;57610;10296;25852;79018;64777;10048;80232;54994;4289	MI:0007-anti tag coimmunoprecipitation	GO:0016567;GO:0000151;GO:0061630;GO:0010499	protein ubiquitination;ubiquitin ligase complex;ubiquitin protein ligase activity;proteasomal ubiquitin-independent protein catabolic process	14.07.05	modification by ubiquitination, deubiquitination	29911972	The GID/CTLH ubiquitin E3 ligase complex promotes cell proliferation and targets the transcription factor HBP1 for degradation.	None	With a molecular weight of at least 550 kDa, the mammalian GID complex potentially constitutes an exceptionally large E3 ubiquitin ligase. The protein complex contains RMND5A or RMND5B as subunit.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein yippee-like 5;Ran-binding protein 10;E3 ubiquitin-protein transferase MAEA;Armadillo repeat-containing protein 8;Glucose-induced degradation protein 4 homolog;E3 ubiquitin-protein transferase RMND5B;Ran-binding protein 9;WD repeat-containing protein 26;Glucose-induced degradation protein 8 homolog;Muskelin	YPEL5;RANBP10;MAEA;ARMC8;GID4;RMND5B;RANBP9;WDR26;GID8;MKLN1	None;KIAA1464;EMP;None;C17orf39,VID24;None;RANBPM;CDW2 MIP2;C20orf11 TWA1;None
8407	TCTEX1 Ca2+ channel complex	Human	None	HEK293 cells	O00555;P63172;Q00975	773;6993;774	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0008324;GO:0006812;GO:0005216	cation transmembrane transporter activity;cation transport;ion channel activity	20.01.01.01;20.03.01.01	cation transport (H+, Na+, K+, Ca2+ , NH4+, etc.);ion channels	15768038	The TCTEX1, a light-chain subunit of the dynein motor complex, interacts directly and selectively with N- and P/Q-type Ca(2+) channels, but not L-type Ca(2+) channels.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Voltage-dependent P/Q-type calcium channel subunit alpha-1A;Dynein light chain Tctex-type 1;Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1A;DYNLT1;CACNA1B	CACH4 CACN3 CACNL1A4;TCTEL1 TCTEX-1 TCTEX1;CACH5 CACNL1A5
8408	CSK-HSP90AA1-HSPA8 complex	Human	HSPA8-Hsp90-CSK2alpha complex	plateles	P07900;P11142;P41240	3320;3312;1445	MI:0019-coimmunoprecipitation;MI:0069-mass spectrometry studies of complexes	GO:0090331	negative regulation of platelet aggregation	None	None	33887528	The complex HSPA8/Hsp90/CSK2alpha is involved in diabetes-related platelet hyperreactivity. The role of the HSPA8/Hsp90/CSK2alpha complex may become a molecular target for the development of future preventive and therapeutic strategies for platelet dysfunction associated with diabetes and its complications (PMID:33887528).	Diabetes mellitus, type  II (PMID:33887528).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Heat shock protein HSP 90-alpha;Heat shock cognate 71 kDa protein;Tyrosine-protein kinase CSK	HSP90AA1;HSPA8;CSK	HSP90A HSPC1 HSPCA;HSC70 HSP73 HSPA10;None
8409	CSNK1A1-CSNK1E-NR3C2 complex	Human	CK1alpha-CK1epsilon-MR complex	HEK cells	P08235;P48729;P49674	4306;1452;102800317	MI:0019-coimmunoprecipitation	GO:0031959	mineralocorticoid receptor signaling pathway	None	None	34847273	o-immunoprecipitation experiments indicated that the MR is located in a protein-protein complex with CK1? and CK1?. Reporter gene assays with pharmacological inhibitors and MR constructs demonstrated that especially CK1? acts as a positive modulator of GRE activity via the C-terminal MR domains CDEF. CK1 enhanced the binding affinity of aldosterone to the MR, facilitated nuclear translocation and DNA interaction of the MR, and led to expression changes of pathophysiologically relevant genes like Per-1 and Phlda1 (PMID:34847273).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mineralocorticoid receptor;Casein kinase I isoform alpha;Casein kinase I isoform epsilon	NR3C2;CSNK1A1;CSNK1E	MCR MLR;None;None
8410	MAGEA3-MAGEC2-TRIM28 complex	Human	None	HepG2 cells	P43357;Q13263;Q9UBF1	4102;10155;51438	MI:0019-coimmunoprecipitation	GO:0000151;GO:0006511	ubiquitin ligase complex;ubiquitin-dependent protein catabolic process	14.13.01.01	proteasomal degradation (ubiquitin/proteasomal pathway)	28394358	The MAGEA3-MAGEC2-TRIM28 complex promotes the Warburg effect and hepatocellular carcinoma progression by targeting Fructose-1,6-biphosphatase (FBP1) for degradation.	FBP1 protein levels inversely correlate with TRIM28 expression in HCC patient specimens.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Melanoma-associated antigen 3;Transcription intermediary factor 1-beta;Melanoma-associated antigen C2	MAGEA3;TRIM28;MAGEC2	MAGE3;KAP1 RNF96 TIF1B;HCA587,MAGEE1
8411	CA9-MYCBPAP complex	Human	AMAP1-CAIX complex	MDA-MB-231 cells	Q16790;Q8TBZ2	768;84073	MI:0019-coimmunoprecipitation	GO:0032456	endocytic recycling	None	None	34742153	AMAP1 associated with the CAIX protein complex, and they colocalized at the plasma membrane and tubulovesicular structures. AMAP1 knockdown reduced total/surface CAIX, induced its lysosomal accumulation and degradation, and affected intracellular/extracellular pH-Analyzing the physical and functional cooperation between CAIX and AMAP1, the authors were focused on the trafficking to the plasma membrane.(PMID:34742153).	None	None	Homo sapiens (Human);Homo sapiens (Human)	Carbonic anhydrase 9;MYCBP-associated protein	CA9;MYCBPAP	G250 MN;AMAP1
8412	CDC42-FCHSD2-WASL complex	Human	CDC42-FCHSD2-N-WASP complex	epithelial cells	O00401;O94868;P60953	8976;9873;998	MI:0401-biochemical	GO:0060491	regulation of cell projection assembly	None	None	34520816	It was suggested that FCHSD2 cooperates with CDC42 and N-WASP to regulate cell protrusion formation in a membrane-dependent manner (PMID: 34520816).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Actin nucleation-promoting factor WASL;F-BAR and double SH3 domains protein 2;Cell division control protein 42 homolog	WASL;FCHSD2;CDC42	None;KIAA0769 SH3MD3;None
8414	DOT1L-MLLT10 complex	Human	DOT1L\u2013AF10 complex	None	P55197;Q8TEK3	8028;84444	MI:0114-x-ray crystallography	GO:0016571	histone methylation	None	None	34414607	None	Leukemogenic transformation (PMID:34414607).	None	Homo sapiens (Human);Homo sapiens (Human)	Protein AF-10;Histone-lysine N-methyltransferase, H3 lysine-79 specific	MLLT10;DOT1L	AF10;KIAA1814 KMT4
8415	MTERF4-NSUN4 complex	Human	MTERF4-NSUN4 complex	None	Q7Z6M4;Q96CB9	130916;387338	MI:0114-x-ray crystallography	GO:0042255;GO:0005739	ribosome assembly;mitochondrion	70.16	mitochondrion	22949673	This study provides a molecular explanation for MTERF4-dependent recruitment of NSUN4 to ribosomal RNA and suggests a unique mechanism by which other members of the large MTERF-family of proteins can regulate ribosomal biogenesis (PMID:22949673).	None	None	Homo sapiens (Human);Homo sapiens (Human)	Transcription termination factor 4, mitochondrial;5-methylcytosine rRNA methyltransferase NSUN4	MTERF4;NSUN4	MTERFD2;None
8416	HFE-HJV-TFR2 complex	Human	None	HuH7 hepatoma-derived cells	Q30201;Q6ZVN8;Q9UP52	3077;148738;7036	MI:0019-coimmunoprecipitation;MI:0029-cosedimentation through density gradient	GO:0055072	iron ion homeostasis	None	None	22728873	HFE, TfR2, and HJV physically interact on the surface of hepatocytes. This complex controls the iron hormone hepcidin (PMID: 22728873).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Hereditary hemochromatosis protein;Hemojuvelin;Transferrin receptor protein 2	HFE;HJV;TFR2	HLAH;HFE2 RGMC;None
8417	SOX9-TRAP complex	Human	None	None	O60244;O75448;O75586;P24863;P48436;Q15648;Q71SY5;Q93074;Q9NVC6;Q9UHV7;Q9Y2W1;Q9Y2X0	9282;9862;10001;892;6662;5469;81857;9968;9440;9969;9967;10025	MI:0071-molecular sieving	GO:0006355	regulation of DNA-templated transcription	11.02.03.04	transcriptional control	12136106	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mediator of RNA polymerase II transcription subunit 14;Mediator of RNA polymerase II transcription subunit 24;Mediator of RNA polymerase II transcription subunit 6;Cyclin-C;Transcription factor SOX-9;Mediator of RNA polymerase II transcription subunit 1;Mediator of RNA polymerase II transcription subunit 25;Mediator of RNA polymerase II transcription subunit 12;Mediator of RNA polymerase II transcription subunit 17;Mediator of RNA polymerase II transcription subunit 13;Thyroid hormone receptor-associated protein 3;Mediator of RNA polymerase II transcription subunit 16	MED14;MED24;MED6;CCNC;SOX9;MED1;MED25;MED12;MED17;MED13;THRAP3;MED16	ARC150 CRSP2 CXorf4 DRIP150 EXLM1 RGR1 TRAP170;ARC100 CRSP4 DRIP100 KIAA0130 THRAP4 TRAP100;ARC33;None;None;ARC205 CRSP1 CRSP200 DRIP205 DRIP230 PBP PPARBP PPARGBP RB18A TRAP220 TRIP2;ACID1 ARC92 PTOV2;ARC240 CAGH45 HOPA KIAA0192 TNRC11 TRAP230;ARC77 CRSP6 DRIP77 DRIP80 TRAP80;ARC250 KIAA0593 THRAP1 TRAP240;BCLAF2 TRAP150;DRIP92 THRAP5
8418	LY96-TLR4 complex	Human	TLR4-MD-2 intermediate complex; Toll-like receptor 4-MD-2 complex	HEK293 cells	O00206;Q9Y6Y9	7099;23643	MI:0007-anti tag coimmunoprecipitation	GO:0034142;GO:0045087;GO:0042742;GO:0002224;GO:0051092;GO:0045893;GO:0001530;GO:0032496	toll-like receptor 4 signaling pathway;innate immune response;defense response to bacterium;toll-like receptor signaling pathway;positive regulation of NF-kappaB transcription factor activity;positive regulation of DNA-templated transcription;lipopolysaccharide binding;response to lipopolysaccharide	36.25.16.01;11.02.03.04.01	innate immune response (invertebrates and vertebrates);transcription activation	11706042	LPS is transferred to the TLR4-MD-2 complex by two accessory proteins, LPS-binding protein (LBP) and CD14.(PMID:16953972). Selected N-linked glycosylation sites of both MD-2 and TLR4 play key roles in the maintenance of the ability of the LPS receptor to recognize LPS (PMID:11706042).	None	None	Homo sapiens (Human);Homo sapiens (Human)	Toll-like receptor 4;Lymphocyte antigen 96	TLR4;LY96	None;ESOP1 MD2
8419	MAGEA2-TRIM28 complex	Human	None	HEK293 cells	P43356;Q13263	266740;10155	MI:0019-coimmunoprecipitation;MI:0676-tandem affinity purification	GO:0006511;GO:0005634;GO:0000151	ubiquitin-dependent protein catabolic process;nucleus;ubiquitin ligase complex	14.13.01.01;70.10	proteasomal degradation (ubiquitin/proteasomal pathway);nucleus	20864041	The MAGEA2-TRIM28 complex enhances TRIM28-mediated p53 ubiquitylation.	MAGEA2 is highly expressed in glioma and breast cancer (PMID:\u00a030185218).	None	Homo sapiens (Human);Homo sapiens (Human)	Melanoma-associated antigen 2;Transcription intermediary factor 1-beta	MAGEA2;TRIM28	MAGE2 MAGEA2A;KAP1 RNF96 TIF1B
8420	Cohesin complex, incomplete (USP13, SMC3, STAG2)	Human	None	293T cells	Q8N3U4;Q92995;Q9UQE7	10735;8975;9126	MI:0019-coimmunoprecipitation	GO:0016579;GO:0016567	protein deubiquitination;protein ubiquitination	14.07.05	modification by ubiquitination, deubiquitination	33334891	These results identify USP13 as a new cohesin-interacting protein that regulates the ubiquitination of cohesin and its cell cycle regulated interaction with chromatin (PMID:.33334891)	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cohesin subunit SA-2;Ubiquitin carboxyl-terminal hydrolase 13;Structural maintenance of chromosomes protein 3	STAG2;USP13;SMC3	SA2;ISOT3;BAM BMH CSPG6 SMC3L1
8421	LPS receptor complex	Human	Toll-like receptor 4-MD-2-CD14 complex; TLR4-MD-2-CD14 complex; CD14-LY96-TLR4 complex	HEK293 cells	O00206;P08571;Q9Y6Y9	7099;929;23643	MI:0007-anti tag coimmunoprecipitation;MI:0030-cross-linking study	GO:0045087;GO:0034142;GO:0001530;GO:0002221;GO:0002224;GO:0042742;GO:0032496;GO:0051092;GO:0045893;GO:0031663	innate immune response;toll-like receptor 4 signaling pathway;lipopolysaccharide binding;pattern recognition receptor signaling pathway;toll-like receptor signaling pathway;defense response to bacterium;response to lipopolysaccharide;positive regulation of NF-kappaB transcription factor activity;positive regulation of DNA-templated transcription;lipopolysaccharide-mediated signaling pathway	36.25.16.01;11.02.03.04.01	innate immune response (invertebrates and vertebrates);transcription activation	11274165	LPS in the bloodstream binds to the soluble lipopolysaccharide binding protein (LBP) and these intermediate complexes are presented to CD14 (PMID:1698311; 28115037). LPS requires the presence of the tripartite complex composed of CD14\u00b7TLR4\u00b7MD-2 to bind TLR4 and MD-2 (PMID:11274165).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Toll-like receptor 4;Monocyte differentiation antigen CD14;Lymphocyte antigen 96	TLR4;CD14;LY96	None;None;ESOP1 MD2
8424	MAGEA3-TRIM28 complex	Human	None	HEK293 cells	P43357;Q13263	4102;10155	MI:0019-coimmunoprecipitation;MI:0676-tandem affinity purification	GO:0006511;GO:0000151	ubiquitin-dependent protein catabolic process;ubiquitin ligase complex	14.13.01.01	proteasomal degradation (ubiquitin/proteasomal pathway)	20864041	None	In an orthotopic xenograft model of thyroid cancer, overexpression of MAGE-A3 promotes increased cell proliferation and primary tumor size, as well as increased number and size of lung metastatic foci (PMID: 18829569).	None	Homo sapiens (Human);Homo sapiens (Human)	Melanoma-associated antigen 3;Transcription intermediary factor 1-beta	MAGEA3;TRIM28	MAGE3;KAP1 RNF96 TIF1B
8425	MAGEA6-TRIM28 complex	Human	None	HEK293 cells	P43360;Q13263	4105;10155	MI:0019-coimmunoprecipitation;MI:0676-tandem affinity purification	GO:0006511;GO:0000151	ubiquitin-dependent protein catabolic process;ubiquitin ligase complex	14.13.01.01	proteasomal degradation (ubiquitin/proteasomal pathway)	20864041	The MAGEA6-TRIM28 complex promotes p53 degradation in cells.	MAGEA6 is highly expressed in breast, colon, and lung cancer (PMID:\u00a030185218).	None	Homo sapiens (Human);Homo sapiens (Human)	Melanoma-associated antigen 6;Transcription intermediary factor 1-beta	MAGEA6;TRIM28	MAGE6;KAP1 RNF96 TIF1B
8426	MAGEC2-TRIM28 complex	Human	None	HEK293 cells	Q13263;Q9UBF1	10155;51438	MI:0019-coimmunoprecipitation;MI:0676-tandem affinity purification	GO:0005634;GO:0006511;GO:0000151	nucleus;ubiquitin-dependent protein catabolic process;ubiquitin ligase complex	70.10;14.13.01.01	nucleus;proteasomal degradation (ubiquitin/proteasomal pathway)	20864041	The MAGEC2-TRIM28 complex was shown to target p53 for degradation in a proteasome-dependent manner.	MAGEC2 is highly expressed in hepatocellular carcinoma; breast, lung cancer; melanoma; gastrointestinal stromal tumors (PMID:\u00a030185218).	None	Homo sapiens (Human);Homo sapiens (Human)	Transcription intermediary factor 1-beta;Melanoma-associated antigen C2	TRIM28;MAGEC2	KAP1 RNF96 TIF1B;HCA587,MAGEE1
8427	MAGED1-PJA1 complex	Human	None	HEK293 cells	Q8NG27;Q9Y5V3	64219;9500	MI:0019-coimmunoprecipitation;MI:0676-tandem affinity purification	GO:0000151	ubiquitin ligase complex	None	None	20864041	None	MAGED1 is highly expressed in breast cancer (PMID:\u00a030185218).	None	Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase Praja-1;Melanoma-associated antigen D1	PJA1;MAGED1	RNF70;NRAGE
8428	MAGEF1-NSMCE1 complex	Human	MAGEF1-NSE1 complex	HEK293 cells	Q8WV22;Q9HAY2	197370;64110	MI:0019-coimmunoprecipitation;MI:0676-tandem affinity purification	GO:0000151	ubiquitin ligase complex	None	None	20864041	None	MAGEF1 is highly expressed in colorectal, ovarian, breast, cervical cancer; melanoma and leukemia (PMID:\u00a030185218).	None	Homo sapiens (Human);Homo sapiens (Human)	Non-structural maintenance of chromosomes element 1 homolog;Melanoma-associated antigen F1	NSMCE1;MAGEF1	None;None
8429	NSMCE1-NSMCE3 complex	Human	MAGEG1-NSE1 complex	HEK293 cells	Q8WV22;Q96MG7	197370;56160	MI:0019-coimmunoprecipitation;MI:0114-x-ray crystallography;MI:0676-tandem affinity purification	GO:0005634;GO:0000151	nucleus;ubiquitin ligase complex	70.10	nucleus	20864041	MAGE-G1 (NSMCE3) directly enhances NSE1 ubiquitin ligase activity in vitro through binding NSE1 (NSMCE1).	None	None	Homo sapiens (Human);Homo sapiens (Human)	Non-structural maintenance of chromosomes element 1 homolog;Non-structural maintenance of chromosomes element 3 homolog	NSMCE1;NSMCE3	None;HCA4 MAGEG1 NDNL2
8430	NSMCE3-PJA1 complex	Human	MAGEG1-PJA1 complex	HEK293 cells	Q8NG27;Q96MG7	64219;56160	MI:0019-coimmunoprecipitation;MI:0676-tandem affinity purification	GO:0000151	ubiquitin ligase complex	None	None	20864041	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase Praja-1;Non-structural maintenance of chromosomes element 3 homolog	PJA1;NSMCE3	RNF70;HCA4 MAGEG1 NDNL2
8431	MAGEL2-TRIM27 complex	Human	None	HEK293 cells	P14373;Q9UJ55	5987;54551	MI:0019-coimmunoprecipitation;MI:0676-tandem affinity purification	GO:0000151	ubiquitin ligase complex	None	None	20864041	None	Truncating mutations of MAGEL2 cause Prader-Willi phenotypes and autism (PMID: 24076603).	None	Homo sapiens (Human);Homo sapiens (Human)	Zinc finger protein RFP;MAGE-like protein 2	TRIM27;MAGEL2	RFP RNF76;NDNL1
8432	CD36-TLR4-TLR6 complex	Human	TLR4-TLR6-CD36 complex; Toll-like receptor 4-Toll-like receptor 6-CD36 complex; CD36-TLR4-TLR6 complex	THP-1 monocytes treated with oxLDL or beta-amyloid; HEK293 cells	O00206;P16671;Q9Y2C9	7099;948;10333	MI:0019-coimmunoprecipitation;MI:0416-fluorescence microscopy	GO:0002224;GO:0045087;GO:0050729;GO:0002221;GO:0030169;GO:0001540;GO:0035666;GO:0002755;GO:0051092;GO:0032732;GO:0006952;GO:0140052	toll-like receptor signaling pathway;innate immune response;positive regulation of inflammatory response;pattern recognition receptor signaling pathway;low-density lipoprotein particle binding;amyloid-beta binding;TRIF-dependent toll-like receptor signaling pathway;MyD88-dependent toll-like receptor signaling pathway;positive regulation of NF-kappaB transcription factor activity;positive regulation of interleukin-1 production;defense response;cellular response to oxidised low-density lipoprotein particle stimulus	36.25.16.01	innate immune response (invertebrates and vertebrates)	20037584	Activation of the CD36-TLR4-TLR6 complex is a common molecular mechanism by which atherogenic lipids (oxLDL) or beta-amyloid stimulate sterile inflammation. Recognition of oxLDL and beta-amyloid peptide by CD36 triggers assembly of the CD36-TLR4-TLR6 complex.	In atherosclerosis and Alzheimer's disease, deposition of the altered self components oxLDL and amyloid-beta triggers a protracted sterile inflammatory response by inducing the TLR4-TLR6-CD36 complex.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Toll-like receptor 4;Platelet glycoprotein 4;Toll-like receptor 6	TLR4;CD36;TLR6	None;GP3B GP4;None
8435	TLR3 signaling complex	Human	MAP3K7-TAB2-TLR3-TRAF6 complex; TLR3-TAK1-TAB2-TRAF6 complex	HEK293 cells, poly(I-C) stimulated	O15455;O43318;Q9NYJ8;Q9Y4K3	7098;6885;23118;7189	MI:0007-anti tag coimmunoprecipitation;MI:0096-pull down	GO:0045087;GO:0043331;GO:0034138;GO:0043410;GO:0031347;GO:0051092;GO:0002221;GO:0002224	innate immune response;response to dsRNA;toll-like receptor 3 signaling pathway;positive regulation of MAPK cascade;regulation of defense response;positive regulation of NF-kappaB transcription factor activity;pattern recognition receptor signaling pathway;toll-like receptor signaling pathway	36.25.16.01	innate immune response (invertebrates and vertebrates)	12609980	Upon stimulation with dsRNA TLR3 induces TRAF6, TAK1, and TAB2 translocation from the membrane to the cytosol, forming a unique receptor complex that  leads to activation of NFkappaB and MAP kinase.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Toll-like receptor 3;Mitogen-activated protein kinase kinase kinase 7;TGF-beta-activated kinase 1 and MAP3K7-binding protein 2;TNF receptor-associated factor 6	TLR3;MAP3K7;TAB2;TRAF6	None;TAK1;KIAA0733, MAP3K7IP2;RNF85
8438	IRAK1-TOLLIP complex, unstimulated	Human	TOLLIP-IRAK complex	HEK293T cells, before IL-1 stimulation	P51617;Q9H0E2	3654;54472	MI:0007-anti tag coimmunoprecipitation	GO:0070498;GO:0006955;GO:0045087;GO:0006952	interleukin-1-mediated signaling pathway;immune response;innate immune response;defense response	36.25.16;36.25.16.01	immune response;innate immune response (invertebrates and vertebrates)	10854325	The TOLLIP-IRAK complex pre-exists without IL-1beta stimulation. Recruitment of the TOLLIP-IRAK complex to the activated IL-1 receptor complex occurs through association of Tollip with IL-1RAcP (IL1RAP).	None	None	Homo sapiens (Human);Homo sapiens (Human)	Interleukin-1 receptor-associated kinase 1;Toll-interacting protein	IRAK1;TOLLIP	IRAK;None
8439	IL1R1-IL1RAP-IRAK1-MYD88-TOLLIP complex	Human	IL-1 receptor type 1-IRAK-MYD88-TOLLIP complex; IL1R1-IL1RAP-IRAK1-MYD88-TOLLIP complex, IL-1-stimulated	HEK293T cells, IL-1beta stimulated	P14778;P51617;Q99836;Q9H0E2;Q9NPH3	3554;3654;4615;54472;3556	MI:0007-anti tag coimmunoprecipitation	GO:0070498;GO:0006955;GO:0051092;GO:0006952;GO:0019221;GO:0050727;GO:0070555;GO:0045087	interleukin-1-mediated signaling pathway;immune response;positive regulation of NF-kappaB transcription factor activity;defense response;cytokine-mediated signaling pathway;regulation of inflammatory response;response to interleukin-1;innate immune response	36.25.16;36.25.16.01	immune response;innate immune response (invertebrates and vertebrates)	10854325	After IL-1beta stimulation, the preformed TOLLIP-IRAK complex is recruited to the activated IL-1beta receptor (IL-1RAcP-IL-1R1) through association of Tollip with IL-1RAcP. Tollip may not only link IRAK to the IL-1 receptor but may also inhibit phosphorylation of IRAK to keep IRAK in an \u2018off\u2019 state before formation of an IL-1-induced complex with its activator MyD88.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Interleukin-1 receptor type 1;Interleukin-1 receptor-associated kinase 1;Myeloid differentiation primary response protein MyD88;Toll-interacting protein;Interleukin-1 receptor accessory protein	IL1R1;IRAK1;MYD88;TOLLIP;IL1RAP	IL1R IL1RA IL1RT1;IRAK;None;None;C3orf13 IL1R3
8441	CCR4-NOT-TOB1 complex	Human	None	HeLa S3 cells	A5YKK6;O75175;P50616;Q92600;Q96LI5;Q9H9A5;Q9NZN8;Q9UIV1	23019;4849;10140;9125;246175;25904;4848;29883	MI:0019-coimmunoprecipitation;MI:0091-chromatography technology	GO:0006355;GO:0000288	regulation of DNA-templated transcription;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	11.02.03.04	transcriptional control	18377426	None	None	The study showed that Tob1 protein associates with the components of the CCR4-NOT complex except Cnot4, Cnot6,and Cnot8. The authors assume that Tob1 could associate with the whole CCR4-NOT complex. The reason why the study failed to identify Cnot4, Cnot6, and Cnot8 in the Tob immunoprecipitates is unclear.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	CCR4-NOT transcription complex subunit 1;CCR4-NOT transcription complex subunit 3;Protein Tob1;CCR4-NOT transcription complex subunit 9;CCR4-NOT transcription complex subunit 6-like;CCR4-NOT transcription complex subunit 10;CCR4-NOT transcription complex subunit 2;CCR4-NOT transcription complex subunit 7	CNOT1;CNOT3;TOB1;CNOT9;CNOT6L;CNOT10;CNOT2;CNOT7	CDC39, KIAA1007, NOT1;KIAA0691 LENG2 NOT3;TOB,TROB1;RCD1 RQCD1;CCR4B;None;CDC36 NOT2;CAF1
8442	AR-MAGEA11 complex	Human	None	COS1 cells; LAPC-4 human prostate cancer cells	P10275;P43364	367;4110	MI:0007-anti tag coimmunoprecipitation	GO:0045893;GO:2000825	positive regulation of DNA-templated transcription;positive regulation of androgen receptor activity	11.02.03.04.01	transcription activation	23172223	MAGEA11 enhances transcriptional activity by linking androgen receptor dimers.	Increased expression of MAGEA11 during prostate cancer progression enhances androgen receptor signaling and prostate cancer growth.	None	Homo sapiens (Human);Homo sapiens (Human)	Androgen receptor;Melanoma-associated antigen 11	AR;MAGEA11	DHTR, NR3C4;MAGE11
8445	CBL-EGFR-VAV2 complex	Human	None	MCF-10A cells	P00533;P22681;P52735	1956;867;7410	MI:0019-coimmunoprecipitation	GO:0007165;GO:0016567;GO:0034334	signal transduction;protein ubiquitination;adherens junction maintenance	30;14.07.05	CELLULAR COMMUNICATION/SIGNAL TRANSDUCTION MECHANISM;modification by ubiquitination, deubiquitination	20940296	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Epidermal growth factor receptor;E3 ubiquitin-protein ligase CBL;Guanine nucleotide exchange factor VAV2	EGFR;CBL;VAV2	ERBB ERBB1 HER1;CBL2 RNF55;None
8446	ASXL1-BAP1 complex	Human	None	HeLa S3 cells	Q8IXJ9;Q92560	171023;8314	MI:0019-coimmunoprecipitation	GO:0016579	protein deubiquitination	14.07.05	modification by ubiquitination, deubiquitination	26416890	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Polycomb group protein ASXL1;Ubiquitin carboxyl-terminal hydrolase BAP1	ASXL1;BAP1	KIAA0978;KIAA0272
8447	ASXL2-BAP1 complex	Human	None	HeLa S3 cells	Q76L83;Q92560	55252;8314	MI:0019-coimmunoprecipitation	GO:0016579;GO:0090398	protein deubiquitination;cellular senescence	14.07.05	modification by ubiquitination, deubiquitination	26416890	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Putative Polycomb group protein ASXL2;Ubiquitin carboxyl-terminal hydrolase BAP1	ASXL2;BAP1	ASXH2,KIAA1685;KIAA0272
8448	CUL3-KBTBD6 complex	Human	None	HEK293T cells	Q13618;Q86V97	8452;89890	MI:0019-coimmunoprecipitation	GO:0016567	protein ubiquitination	14.07.05	modification by ubiquitination, deubiquitination	25684205	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cullin-3;Kelch repeat and BTB domain-containing protein 6	CUL3;KBTBD6	KIAA0617;None
8449	CUL3-KBTBD7 complex	Human	None	HEK293T cells	Q13618;Q8WVZ9	8452;84078	MI:0019-coimmunoprecipitation	GO:0016567	protein ubiquitination	14.07.05	modification by ubiquitination, deubiquitination	25684205	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cullin-3;Kelch repeat and BTB domain-containing protein 7	CUL3;KBTBD7	KIAA0617;None
8450	AP-3-KIF3A-RAB4A-RBSN complex	Human	None	HeLa cells	O14617;P20338;Q92572;Q9H1K0;Q9Y496	8943;5867;1176;64145;11127	MI:0019-coimmunoprecipitation	GO:0035459;GO:0097443;GO:1903232	vesicle cargo loading;sorting endosome;melanosome assembly	None	None	30154210	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	AP-3 complex subunit delta-1;Ras-related protein Rab-4A;AP-3 complex subunit sigma-1;Rabenosyn-5;Kinesin-like protein KIF3A	AP3D1;RAB4A;AP3S1;RBSN;KIF3A	None;RAB4;CLAPS3;ZFYVE20;KIF3
8452	SBNO1-TEAD4-YAP1 complex	Human	None	293T cells	A3KN83;P46937;Q15561	55206;10413;7004	MI:0019-coimmunoprecipitation	GO:0009790	embryo development	None	None	28401892	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein strawberry notch homolog 1;Transcriptional coactivator YAP1;Transcriptional enhancer factor TEF-3	SBNO1;YAP1;TEAD4	MOP3;YAP65;RTEF1 TCF13L1 TEF3
8453	NOTCH1-RBPJ-SBNO1 complex	Human	None	293T cells	A3KN83;P46531;Q06330	55206;4851;3516	MI:0019-coimmunoprecipitation	GO:0009790	embryo development	None	None	28401892	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein strawberry notch homolog 1;Neurogenic locus notch homolog protein 1;Recombining binding protein suppressor of hairless	SBNO1;NOTCH1;RBPJ	MOP3;TAN1;IGKJRB IGKJRB1 RBPJK RBPSUH
8454	SMC5-SMC6 heterodimer	Human	None	fibroblasts	Q8IY18;Q96SB8	23137;79677	MI:0019-coimmunoprecipitation	GO:0003682;GO:0005634;GO:0051321	chromatin binding;nucleus;meiotic cell cycle	70.10	nucleus	11408570	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Structural maintenance of chromosomes protein 5;Structural maintenance of chromosomes protein 6	SMC5;SMC6	KIAA0594 SMC5L1;SMC6L1
8455	EP300-TP53 complex	Human	p300-p53 complex	HCM cells	P04637;Q09472	7157;2033	MI:0019-coimmunoprecipitation	GO:0010468;GO:0010659	regulation of gene expression;cardiac muscle cell apoptotic process	None	None	28131915	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cellular tumor antigen p53;Histone acetyltransferase p300	TP53;EP300	P53;P300
8456	ALYREF-DDX39B-SARNP complex	Human	ALY-UAP56-CIP29 complex	HeLa cells	P82979;Q13838;Q86V81	84324;7919;10189	MI:0019-coimmunoprecipitation	GO:0006406	mRNA export from nucleus	None	None	20844015	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	SAP domain-containing ribonucleoprotein;Spliceosome RNA helicase DDX39B;THO complex subunit 4	SARNP;DDX39B;ALYREF	HCC1;BAT1 UAP56;ALY BEF THOC4
8457	AREX complex	Human	DDX39A-SARNP complex; URH49-CIP29 complex	HeLa cells	O00148;P82979	10212;84324	MI:0019-coimmunoprecipitation	GO:0006406	mRNA export from nucleus	None	None	20573985	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	ATP-dependent RNA helicase DDX39A;SAP domain-containing ribonucleoprotein	DDX39A;SARNP	DDX39;HCC1
8458	TANK-USP10-ZC3H12A complex	Human	None	HEK293 cells	Q14694;Q5D1E8;Q92844	9100;80149;10010	MI:0019-coimmunoprecipitation	GO:0016579;GO:0006974	protein deubiquitination;cellular response to DNA damage stimulus	14.07.05;32.01.09	modification by ubiquitination, deubiquitination;DNA damage response	25861989	The TANK-USP10-ZC3H12A complex is essential for the USP10-dependent deubiquitination of TRAF6 and the resolution of genotoxic NF-kappaB activation upon DNA damage.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Ubiquitin carboxyl-terminal hydrolase 10;Endoribonuclease ZC3H12A;TRAF family member-associated NF-kappa-B activator	USP10;ZC3H12A;TANK	KIAA0190;MCPIP MCPIP1;ITRAF TRAF2
8460	HNRNPL-SETD2 complex	Human	HnRNP-L-KMT3a complex	HEK293 cells	P14866;Q9BYW2	3191;29072	MI:0019-coimmunoprecipitation	GO:0097198	histone H3-K36 trimethylation	None	None	19332550	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Heterogeneous nuclear ribonucleoprotein L;Histone-lysine N-methyltransferase SETD2	HNRNPL;SETD2	HNRPL;HIF1 HYPB KIAA1732 KMT3A SET2
8463	BRISC complex	Human	None	HeLa cells	P46736;Q15018;Q9NWV8;Q9NXR7	79184;23172;29086;9577	MI:0019-coimmunoprecipitation	GO:0016579	protein deubiquitination	14.07.05	modification by ubiquitination, deubiquitination	19214193	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Lys-63-specific deubiquitinase BRCC36;BRISC complex subunit Abraxas 2;BRISC and BRCA1-A complex member 1;BRISC and BRCA1-A complex member 2	BRCC3;ABRAXAS2;BABAM1;BABAM2	BRCC36 C6.1A CXorf53;ABRO1,FAM175B,KIAA0157;C19orf62 MERIT40 NBA1;BRCC45 BRE
8465	ESR1-MAGEA2-TP53 complex	Human	None	T47DTR line; MCF-7VA cells; C18/C24 cells	P03372;P04637;P43356	2099;7157;266740	MI:0019-coimmunoprecipitation	GO:0005634;GO:0033148;GO:0072331	nucleus;positive regulation of intracellular estrogen receptor signaling pathway;signal transduction by p53 class mediator	70.10	nucleus	24662835	The MAGEA2 protein localizes to the nucleus and forms complexes with p53 and ERalpha, resulting in repression of the p53 pathway but increased ER-dependent signaling.	In a series of tamoxifen-treated breast cancer patients, the authors showed a highly significant association between MAGEA expression and reduced overall survival, confirming the clinical significance of the observations.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Estrogen receptor;Cellular tumor antigen p53;Melanoma-associated antigen 2	ESR1;TP53;MAGEA2	ESR NR3A1;P53;MAGE2 MAGEA2A
8466	DAAM1-INTU-NPHP4 complex	Human	None	HEK 293T cells	O75161;Q9ULD6;Q9Y4D1	261734;27152;23002	MI:0019-coimmunoprecipitation	GO:0060271	cilium assembly	None	None	26644512	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Nephrocystin-4;Protein inturned;Disheveled-associated activator of morphogenesis 1	NPHP4;INTU;DAAM1	KIAA0673;KIAA1284,PDZD6,PDZK6;KIAA0666
8467	E2F1-MAGEA11-SKP2 complex	Human	None	COS1 cells	P43364;Q01094;Q13309	4110;1869;6502	MI:0007-anti tag coimmunoprecipitation	GO:0010499;GO:1902498	proteasomal ubiquitin-independent protein catabolic process;regulation of protein autoubiquitination	None	None	27720894	MAGE-A11 decreases SKP2-mediated degradation of E2F1 and SKP2 self-ubiquitination. Stabilization of E2F1 by MAGEA11 was associated with sequestration and inactivation of SKP2 through the formation of an E2F1-MAGEA11-SKP2 complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Melanoma-associated antigen 11;Transcription factor E2F1;S-phase kinase-associated protein 2	MAGEA11;E2F1;SKP2	MAGE11;RBBP3;FBXL1
8468	DNAJB9-DNAJC10-TMEM67 complex	Human	TMEM67-ER chaperone complex	HEK293 cells	Q5HYA8;Q8IXB1;Q9UBS3	91147;54431;4189	MI:0019-coimmunoprecipitation	GO:0036503;GO:0005783	ERAD pathway;endoplasmic reticulum	70.07	endoplasmic reticulum	19815549	TMEM67 (MKS3) co-precipitated with mutant proprotein surfactant protein C (SP-C), DNAJB9 (ERdj4), and DNAJC10 (ERdj5), but did not interact with wild-type SP-C.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Meckelin;DnaJ homolog subfamily C member 10;DnaJ homolog subfamily B member 9	TMEM67;DNAJC10;DNAJB9	MKS3;ERDJ5;MDG1
8469	ELL-ICE1-ICE2-ZC3H8 complex	Human	Little elongation complex; LEC	HEK293 cells	P55199;Q659A1;Q8N5P1;Q9Y2F5	8178;79664;84524;23379	MI:0007-anti tag coimmunoprecipitation	GO:0009301;GO:0005634	snRNA transcription;nucleus	70.10	nucleus	23932780	The LEC complex has roles in both the recruitment and elongation stages of Pol II-dependent small nuclear RNA (snRNA) gene transcription.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	RNA polymerase II elongation factor ELL;Little elongation complex subunit 2;Zinc finger CCCH domain-containing protein 8;Little elongation complex subunit 1	ELL;ICE2;ZC3H8;ICE1	C19orf17;BRCC1 NARG2;ZC3HDC8;KIAA0947
8470	Distal appendage	Human	None	RPE cells (hTERT RPE-1, ATCC-CRL-4000)	O15078;O43303;Q4AC94;Q5BJF6;Q5TB80;Q8IW35;Q8TES7;Q96NL6;Q96ST8;Q9UPV0;Q9Y3M2;Q9Y592	80184;9738;26005;4957;22832;79598;85302;132320;84902;22897;25776;51134	MI:0416-fluorescence microscopy	GO:0060271;GO:0097539	cilium assembly;ciliary transition fiber	None	None	29789620	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Centrosomal protein of 290 kDa;Centriolar coiled-coil protein of 110 kDa;C2 domain-containing protein 3;Outer dense fiber protein 2;Centrosomal protein of 162 kDa;Centrosomal protein of 97 kDa;Fas-binding factor 1;Sodium channel and clathrin linker 1;Centrosomal protein of 89 kDa;Centrosomal protein of 164 kDa;Protein chibby homolog 1;Centrosomal protein of 83 kDa	CEP290;CCP110;C2CD3;ODF2;CEP162;CEP97;FBF1;SCLT1;CEP89;CEP164;CBY1;CEP83	BBS14 KIAA0373 NPHP6;CEP110 CP110 KIAA0419;None;None;C6orf84 KIAA1009 QN1;LRRIQ2;ALB KIAA1863;SAP1;CCDC123;KIAA1052 NPHP15;ARB1 C22orf2 CBY PGEA1;CCDC41
8473	NMNAT1-RRP8-SIRT1 complex	Human	NML complex	H1299 cells	O43159;Q96EB6;Q9HAN9	23378;23411;64802	MI:0019-coimmunoprecipitation	GO:0009303	rRNA transcription	11.02.01	rRNA synthesis	23737528	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Ribosomal RNA-processing protein 8;NAD-dependent protein deacetylase sirtuin-1;Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1	RRP8;SIRT1;NMNAT1	KIAA0409 NML;SIR2L1;NMNAT
8474	METTL3-METTL14 complex	Human	None	HeLa cells	Q86U44;Q9HCE5	56339;57721	MI:0007-anti tag coimmunoprecipitation;MI:0071-molecular sieving	GO:0001510;GO:0005634	RNA methylation;nucleus	70.10	nucleus	24316715	The METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation. WTAP, a mammalian splicing factor, can interact with this complex and affect this methylation (see complex-ID 7808).	None	Two-dimensional native SDS PAGE analysis of the co-expressed METTL3 and METTL14 confirmed formation of a complex between these two proteins with a stoichiometry of 1:1.	Homo sapiens (Human);Homo sapiens (Human)	N6-adenosine-methyltransferase catalytic subunit;N6-adenosine-methyltransferase non-catalytic subunit	METTL3;METTL14	MTA70;KIAA1627
8476	DRG1-ZC3H15 complex	Human	DRG1-DFRP1 complex	HeLa S3 cells	Q8WU90;Q9Y295	55854;4733	MI:0019-coimmunoprecipitation	None	None	None	None	19819225	The DRG1-ZC3H15 complex from mice cosediments with polysomes suggesting a role in protein biosynthesis.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Zinc finger CCCH domain-containing protein 15;Developmentally-regulated GTP-binding protein 1	ZC3H15;DRG1	DFRP1 LEREPO4;NEDD3
8477	DRG2-RWDD1 complex	Human	DRG2-DFRP2 complex	HeLa S3 cells	P55039;Q9H446	1819;51389	MI:0019-coimmunoprecipitation	None	None	None	None	19819225	There is no information about a cellular function of the complex so far.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Developmentally-regulated GTP-binding protein 2;RWD domain-containing protein 1	DRG2;RWDD1	None;DFRP2
8484	IL-2Rgamma/IL-7R receptor-IL-7 complex	Human	Interleukin-7R-interleukin-2Rgamma receptor-interleukin-7 complex; IL2RG-IL7-IL7R	COS-7cells	P13232;P16871;P31785	3574;3575;3561	MI:0006-anti bait coimmunoprecipitation;MI:0030-cross-linking study	GO:0006955;GO:0038111;GO:0019221;GO:0042098	immune response;interleukin-7-mediated signaling pathway;cytokine-mediated signaling pathway;T cell proliferation	36.25.16	immune response	8266077	None	Mutations in IL-2RG result in X-linked severe combined immunodeficiency (XSCID), a disease characterized by the presence of few or no T cells.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Interleukin-7;Interleukin-7 receptor subunit alpha;Cytokine receptor common subunit gamma	IL7;IL7R;IL2RG	None;None;None
8489	TFG-TRAF3 complex	Human	None	HEK293T cells; HeLa cells	Q13114;Q92734	7187;10342	MI:0007-anti tag coimmunoprecipitation;MI:0663-confocal microscopy	GO:0045087;GO:0051607;GO:0006888;GO:0016192	innate immune response;defense response to virus;endoplasmic reticulum to Golgi vesicle-mediated transport;vesicle-mediated transport	36.25.16.01;20.09.07.03;20.09.07	innate immune response (invertebrates and vertebrates);ER to Golgi transport;vesicular transport (Golgi network, etc.)	33411856	Following sensing of viral RNA TRAF3 is recruited to TFG.	None	None	Homo sapiens (Human);Homo sapiens (Human)	TNF receptor-associated factor 3;Protein TFG	TRAF3;TFG	CAP-1 CRAF1 TRAFAMN;None
8490	MAVS-TRAF3-TBK1-TFG complex	Human	MAVS-TBK1-TFG-TRAF3 complex	HeLa cells subjected to SeV infection; HEK293T cells	Q13114;Q7Z434;Q92734;Q9UHD2	7187;57506;10342;29110	MI:0006-anti bait coimmunoprecipitation	GO:0051607;GO:0045087;GO:0032479	defense response to virus;innate immune response;regulation of type I interferon production	36.25.16.01	innate immune response (invertebrates and vertebrates)	33411856	TFG is an essential component of the  MAVS-TRAF3-TBK1 complex. Its subcellular localization on the ER-to-Golgi compartments allows efficient recruitment of TRAF3 to its upstream adaptor MAVS, permitting the activation of downstream kinase TBK1.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	TNF receptor-associated factor 3;Mitochondrial antiviral-signaling protein;Protein TFG;Serine/threonine-protein kinase TBK1	TRAF3;MAVS;TFG;TBK1	CAP-1 CRAF1 TRAFAMN;IPS1,KIAA1271,VISA;None;NAK
8492	EYA4-SIX3 complex	Human	None	293 cells	O95343;O95677	6496;2070	MI:0019-coimmunoprecipitation	GO:0005634;GO:0006351	nucleus;DNA-templated transcription	70.10;11	nucleus;TRANSCRIPTION	19606496	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Homeobox protein SIX3;Eyes absent homolog 4	SIX3;EYA4	None;None
8494	TCF4-ZIC2 complex	Human	None	293T cells	O95409;P15884	7546;6925	MI:0019-coimmunoprecipitation	GO:0016055	Wnt signaling pathway	30.05.02.20	Wnt signalling pathway	21908606	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Zinc finger protein ZIC 2;Transcription factor 4	ZIC2;TCF4	None;BHLHB19 ITF2 SEF2
8495	CUL2-ZER1 complex	Human	CUL2-ZYG11BL complex	HEK293 cells	Q13617;Q7Z7L7	8453;10444	MI:0007-anti tag coimmunoprecipitation;MI:0018-two hybrid	None	None	None	None	17304241	ZYG11BL has high levels of expression in skeletal muscle and the testes, in which it is expressed in late pachytene spermatocytes and spermatids.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cullin-2;Protein zer-1 homolog	CUL2;ZER1	None;C9orf60 ZYG ZYG11BL
8497	ZFAND2B complex	Human	BAG6-DERL1-FAF2-NPLOC4-UFD1-ZFAND2B complex	HEK293 cells	P46379;P55072;Q8TAT6;Q8WV99;Q92890;Q96CS3;Q9BUN8	7917;7415;55666;130617;7353;23197;79139	MI:0007-anti tag coimmunoprecipitation	GO:0005783;GO:0045047	endoplasmic reticulum;protein targeting to ER	70.07	endoplasmic reticulum	24160817	The ZFAND2B complex serves as a quality-control complex involved in regulating translocation into the ER of secretory and membrane proteins in a signal-sequence-dependent manner.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Large proline-rich protein BAG6;Transitional endoplasmic reticulum ATPase;Nuclear protein localization protein 4 homolog;AN1-type zinc finger protein 2B;Ubiquitin recognition factor in ER-associated degradation protein 1;FAS-associated factor 2;Derlin-1	BAG6;VCP;NPLOC4;ZFAND2B;UFD1;FAF2;DERL1	BAT3 G3;None;KIAA1499 NPL4;AIRAPL;UFD1L;ETEA KIAA0887 UBXD8 UBXN3B;DER1
8499	IL-2Rgamma/IL-21R receptor-IL-21 complex	Human	Interleukin-2Rgamma-interleukin-21R receptor-interleukin-15 complex; IL2RG-IL21-IL21R complex	T cell line ED40515(-), IL-2gamma-transfected	P31785;Q9HBE4;Q9HBE5	3561;59067;50615	MI:0045-experimental interaction detection	GO:0019221;GO:0006955;GO:0001817;GO:0001787;GO:0038114	cytokine-mediated signaling pathway;immune response;regulation of cytokine production;natural killer cell proliferation;interleukin-21-mediated signaling pathway	36.25.16	immune response	11418623	None	IL-21 has been linked to autoimmune diseases. (PMID: 30773373)	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cytokine receptor common subunit gamma;Interleukin-21;Interleukin-21 receptor	IL2RG;IL21;IL21R	None;None;NILR
8502	CDON-PTCH1 complex	Human	None	Cos7 cells	Q13635;Q4KMG0	5727;50937	MI:0019-coimmunoprecipitation	GO:0007224	smoothened signaling pathway	30.05.02.16	hedgehog-dependent signalling pathway	21802063	None	Missense mutations in CDON cause holoprosencephaly (HPE), a common human congenital anomaly defined by a failure to delineate the midline of the forebrain and/or midface, is associated with diminished Sonic hedgehog (SHH)-pathway activity in development of these structures. Three of the four CDON variants defective in promoting SHH signaling (p.Pro686Ala, p.Val777Glu, and p.Ser937Arg) displayed significantly diminished ability to coprecipitate with PTCH1 .	None	Homo sapiens (Human);Homo sapiens (Human)	Protein patched homolog 1;Cell adhesion molecule-related/down-regulated by oncogenes	PTCH1;CDON	PTCH;CDO
8504	BOC-CDON complex	Human	None	293T cells	Q4KMG0;Q9BWV1	50937;91653	MI:0019-coimmunoprecipitation	GO:0007224	smoothened signaling pathway	30.05.02.16	hedgehog-dependent signalling pathway	21802063	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cell adhesion molecule-related/down-regulated by oncogenes;Brother of CDO	CDON;BOC	CDO;None
8508	CEP78-DCAF1-DYRK2-UBR5 complex	Human	CEP78-EDD1-DYRK2-DDB1(VPRBP) complex	in 293T cells	O95071;Q5JTW2;Q92630;Q9Y4B6	51366;84131;8445;9730	MI:0019-coimmunoprecipitation	GO:0060271;GO:0005813;GO:0061630	cilium assembly;centrosome;ubiquitin protein ligase activity	70.05	centrosome	34259627	None	The interaction of CEP78 with DCAF1 (DDB1, VPRBP), as well as centrosomal recruitment of CEP78 is dramatically reduced by the disease-causing CEP78-L150S mutation..	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase UBR5;Centrosomal protein of 78 kDa;Dual specificity tyrosine-phosphorylation-regulated kinase 2;DDB1- and CUL4-associated factor 1	UBR5;CEP78;DYRK2;DCAF1	EDD EDD1 HYD KIAA0896;C9orf81;None;KIAA0800 RIP VPRBP
8509	CEP19-CEP350-CEP43-RABL2B complex	Human	RABL2-CEP19-FOP-CEP350 complex	retinal pigmented epithelial cells	O95684;Q5VT06;Q96LK0;Q9UNT1	11116;9857;84984;11158	MI:0096-pull down;MI:0676-tandem affinity purification	GO:0000242;GO:0060271	pericentriolar material;cilium assembly	None	None	28625565	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Centrosomal protein 43;Centrosome-associated protein 350;Centrosomal protein of 19 kDa;Rab-like protein 2B	CEP43;CEP350;CEP19;RABL2B	FGFR1OP,FOP;CAP350 KIAA0480;C3orf34;None
8510	CUL2-PTCH1-TCEB1-TCEB2-ZYG11B complex	Human	None	HeLa cells	Q13617;Q13635;Q15369;Q15370;Q9C0D3	8453;5727;6921;6923;79699	MI:0019-coimmunoprecipitation;MI:0071-molecular sieving	GO:0007224	smoothened signaling pathway	30.05.02.16	hedgehog-dependent signalling pathway	26885983	C3H10T1/2 is a mesenchymal stem cell that can differentiate into alkaline phosphatase-positive osteoblasts in response to Shh stimulation.  Knockdown of CUL2 greatly reduced Shh-stimulated osteoblast differentiation. Knockdown of ZYG11B showed a similar tendency with reduced efficacies.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cullin-2;Protein patched homolog 1;Elongin-C;Elongin-B;Protein zyg-11 homolog B	CUL2;PTCH1;ELOC;ELOB;ZYG11B	None;PTCH;TCEB1;TCEB2;KIAA1730
8513	ATRX-SETDB1-TRIM28-ZNF274 complex	Human	None	K562 cells	P46100;Q13263;Q15047;Q96GC6	546;10155;9869;10782	MI:0019-coimmunoprecipitation;MI:0402-chromatin immunoprecipitation assay	GO:1900112;GO:0006355	regulation of histone H3-K9 trimethylation;regulation of DNA-templated transcription	11.02.03.04	transcriptional control	27029610	ATRX co-occupies 3' ZNF exons containing an H3K9me3/H3K36me3 chromatin signature, together with the H3K9 methyltransferase SETDB1, the co-repressor TRIM28, and the transcription factor ZNF274. Deletion of ATRX or ZNF274 leads to a reduction of H3K9me3, particularly at 3' ZNF exons and other H3K9me3/H3K36me3-containing regions, as well as increased DNA damage, and defects in the cell cycle.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Transcriptional regulator ATRX;Transcription intermediary factor 1-beta;Histone-lysine N-methyltransferase SETDB1;Neurotrophin receptor-interacting factor homolog	ATRX;TRIM28;SETDB1;ZNF274	RAD54L XH2;KAP1 RNF96 TIF1B;ESET KIAA0067 KMT1E;ZKSCAN19
8514	PDE6D-RPGR complex	Human	None	HEK293T cells	O43924;Q92834	5147;6103	MI:0019-coimmunoprecipitation	GO:0005929;GO:0007601	cilium;visual perception	34.11.01.03	visual transduction	33808286	None	None	The human RPGR gene consists of at least 22 exons encoding three major transcript isoforms: RPGR-ex1-19, RPGR-skip14/15, and RPGR-ORF15. RPGR-ex1-19 is the widely expressed full-length isoform of RPGR which includes all exons from 1 through 19, whereas RPGR-skip14/15 is generated by the alternative splicing of exons 14 and 15. Notably, skipping of exons 14 and 15 during splicing leads to an in-frame deletion in RPGR transcripts. Both the full-length isoform RPGR-ex1-19 and the isoform RPGR-skip14/15  form a complex with PDE6D.	Homo sapiens (Human);Homo sapiens (Human)	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta;X-linked retinitis pigmentosa GTPase regulator	PDE6D;RPGR	PDED;RP3 XLRP3
8515	INPP5E-RPGR complex	Human	None	HEK293T cells	Q92834;Q9NRR6	6103;56623	MI:0019-coimmunoprecipitation	GO:0007601;GO:0005929	visual perception;cilium	34.11.01.03	visual transduction	33808286	None	None	The human RPGR gene consists of at least 22 exons encoding three major transcript isoforms: RPGR-ex1-19, RPGR-skip14/15, and RPGR-ORF15. RPGR-ex1-19 is the widely expressed full-length isoform of RPGR which includes all exons from 1 through 19, whereas RPGR-skip14/15 is generated by the alternative splicing of exons 14 and 15. Notably, skipping of exons 14 and 15 during splicing leads to an in-frame deletion in RPGR transcripts. In contrast to the full-length isoform RPGR-ex1-19, the isoform RPGR-skip14/15 does not form a complex with INPP5E.	Homo sapiens (Human);Homo sapiens (Human)	X-linked retinitis pigmentosa GTPase regulator;Phosphatidylinositol polyphosphate 5-phosphatase type IV	RPGR;INPP5E	RP3 XLRP3;None
8516	RPGR-RPGRIP1L complex	Human	None	HEK293T cells	Q68CZ1;Q92834	23322;6103	MI:0019-coimmunoprecipitation	GO:0005929;GO:0007601	cilium;visual perception	34.11.01.03	visual transduction	33808286	None	None	The human RPGR gene consists of at least 22 exons encoding three major transcript isoforms: RPGR-ex1-19, RPGR-skip14/15, and RPGR-ORF15. RPGR-ex1-19 is the widely expressed full-length isoform of RPGR which includes all exons from 1 through 19, whereas RPGR-skip14/15 is generated by the alternative splicing of exons 14 and 15. Notably, skipping of exons 14 and 15 during splicing leads to an in-frame deletion in RPGR transcripts. In contrast to the full-length isoform RPGR-ex1-19, the isoform RPGR-skip14/15 does not form a complex with RPGRIP1L.	Homo sapiens (Human);Homo sapiens (Human)	Protein fantom;X-linked retinitis pigmentosa GTPase regulator	RPGRIP1L;RPGR	FTM KIAA1005 NPHP8;RP3 XLRP3
8518	ABCD4-LMBRD1 complex	Human	None	CHO cells	O14678;Q9NUN5	5826;55788	MI:0019-coimmunoprecipitation	GO:0015889	cobalamin transport	None	None	27456980	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Lysosomal cobalamin transporter ABCD4;Lysosomal cobalamin transport escort protein LMBD1	ABCD4;LMBRD1	PXMP1L;C6orf209 NESI
8520	Cone photoreceptor cyclic nucleotide-gated channel	Human	Cone CNG channel	HEK293 cells	Q16281;Q9NQW8	1261;54714	MI:0040-electron microscopy;MI:0400-affinity technology	GO:0007601;GO:0007165;GO:0043855;GO:0035845	visual perception;signal transduction;cyclic nucleotide-gated ion channel activity;photoreceptor cell outer segment organization	34.11.01.03;30	visual transduction;CELLULAR COMMUNICATION/SIGNAL TRANSDUCTION MECHANISM	34969976	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cyclic nucleotide-gated cation channel alpha-3;Cyclic nucleotide-gated cation channel beta-3	CNGA3;CNGB3	CNCG3;None
8521	IL-12RB1/IL-23R receptor-IL-23 complex	Human	Interleukin-12RB1/interleukin-23R receptor-interleukin-23 complex; IL12B-IL12RB1-IL23A-IL23R complex	T cell line Kit225	P29460;P42701;Q5VWK5;Q9NPF7	3593;3594;149233;51561	MI:0006-anti bait coimmunoprecipitation;MI:0045-experimental interaction detection	GO:0019221;GO:0006955;GO:0038155;GO:0032609;GO:0061485;GO:0050727	cytokine-mediated signaling pathway;immune response;interleukin-23-mediated signaling pathway;interferon-gamma production;memory T cell proliferation;regulation of inflammatory response	36.25.16	immune response	12023369	Isolation of the IL-23 heterodimer has been described in PMID: 11114383.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Interleukin-12 subunit beta;Interleukin-12 receptor subunit beta-1;Interleukin-23 receptor;Interleukin-23 subunit alpha	IL12B;IL12RB1;IL23R;IL23A	NKSF2;IL12R IL12RB;None;SGRF
8523	TBK1-TRAF3 complex	Human	None	HEK293 cells	Q13114;Q9UHD2	7187;29110	MI:0006-anti bait coimmunoprecipitation	GO:0045087;GO:0051607;GO:0032481;GO:0039529;GO:0002221;GO:0019048	innate immune response;defense response to virus;positive regulation of type I interferon production;RIG-I signaling pathway;pattern recognition receptor signaling pathway;modulation by virus of host process	36.25.16.01	innate immune response (invertebrates and vertebrates)	18614628	Viruses have evolved several strategies to evade the immune system of the host. Infection with NY-1 hantavirus disrupts TBK1-TRAF3 complex formation by interaction of NY-1 hantavirus Gn protein with TRAF3 thereby inhibiting cellular interferon responses. (PMID:18614628)	None	None	Homo sapiens (Human);Homo sapiens (Human)	TNF receptor-associated factor 3;Serine/threonine-protein kinase TBK1	TRAF3;TBK1	CAP-1 CRAF1 TRAFAMN;NAK
8525	PBX1-PBXIP1 complex	Human	PBX1-HPIP complex	fetal liver-hematopoietic cells	P40424;Q96AQ6	5087;57326	MI:0018-two hybrid;MI:0096-pull down	GO:0003714	transcription corepressor activity	None	None	10825160	It was demonstrated that HPIP interacts with PBX1 invivo and, moreover, that it prevents the binding of PBX1-HOXcomplexes to consensus DNA binding sites. (PMID:10825160)	None	None	Homo sapiens (Human);Homo sapiens (Human)	Pre-B-cell leukemia transcription factor 1;Pre-B-cell leukemia transcription factor-interacting protein 1	PBX1;PBXIP1	PRL;HPIP
8526	PBX2-TLX1 complex	Human	PBX2-HOX11 complex	None	P31314;P40425	3195;5089	MI:0018-two hybrid	GO:0006357	regulation of transcription by RNA polymerase II	None	None	19559479	The co-operation between TLX1 (HOX11) and MEIS proteins may have a significant role in T-cell leukemogenesis (PMID:19559479)	None	None	Homo sapiens (Human);Homo sapiens (Human)	T-cell leukemia homeobox protein 1;Pre-B-cell leukemia transcription factor 2	TLX1;PBX2	HOX11 TCL3;G17
8527	HOXB7-PBX2 complex	Human	None	A375M melanoma cells	P09629;P40425	3217;5089	MI:0019-coimmunoprecipitation	GO:1902893	regulation of miRNA transcription	None	None	23400877	The HOXB7/PBX2 dimer acts as a positive transcriptional regulator of the oncogenic microRNA-221 and -222.(PMID:23400877)	HXR9 treatment results in the downregulation of miR-221 and 222 in human melanoma cells as a consequence of HOXB7/PBX2 heterodimer disruption and the subsequent degradation of HOXB7 and PBX2 proteins. (PMID:23400877)	None	Homo sapiens (Human);Homo sapiens (Human)	Homeobox protein Hox-B7;Pre-B-cell leukemia transcription factor 2	HOXB7;PBX2	HOX2C;G17
8528	PLK4-TENT5C complex	Human	FAM46C-PLK4 complex	HEK293T cells.	O00444;Q5VWP2	10733;54855	MI:0019-coimmunoprecipitation	GO:0005813;GO:0008283;GO:0007283	centrosome;cell population proliferation;spermatogenesis	70.05	centrosome	32433990	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein kinase PLK4;Terminal nucleotidyltransferase 5C	PLK4;TENT5C	SAK,STK18;FAM46C
8529	PLK4-STIL complex	Human	None	293T cells	O00444;Q15468	10733;6491	MI:0019-coimmunoprecipitation	GO:0005814;GO:0007099	centriole;centriole replication	None	None	25342035	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein kinase PLK4;SCL-interrupting locus protein	PLK4;STIL	SAK,STK18;SIL
8530	STING1-TBK1-TRAF3 complex	Human	STING-TRAF3-TBK1 complex; TBK1-TMEM173-TRAF3 complex	HEK293T cells	Q13114;Q86WV6;Q9UHD2	7187;340061;29110	MI:0006-anti bait coimmunoprecipitation	GO:0051607;GO:0032481;GO:0045087;GO:0039529;GO:0002221;GO:0019048	defense response to virus;positive regulation of type I interferon production;innate immune response;RIG-I signaling pathway;pattern recognition receptor signaling pathway;modulation by virus of host process	36.25.16.01	innate immune response (invertebrates and vertebrates)	24622840	Viruses have evolved several strategies to evade the immune system of the host. SARS-CoV papain-like protease interacts with the components of the STING-TRAF3-TBK1 complex and disrupts complex formation leading to inhibition of type I interferon production. This explains how SARS-CoV virus can evade the antiviral activities of type-I-interferon signaling.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	TNF receptor-associated factor 3;Stimulator of interferon genes protein;Serine/threonine-protein kinase TBK1	TRAF3;STING1;TBK1	CAP-1 CRAF1 TRAFAMN;ERIS MITA STING TMEM173;NAK
8533	SNARE complex (SNAP23, STX4, VAMP8)	Human	None	platelet	O00161;Q12846;Q9BV40	8773;6810;8673	MI:0019-coimmunoprecipitation;MI:0047-far western blotting	GO:0016079;GO:0048489;GO:0006906;GO:0031201;GO:0061025	synaptic vesicle exocytosis;synaptic vesicle transport;vesicle fusion;SNARE complex;membrane fusion	20.09.16.09.05;20.09.07.27	synaptic vesicle exocytosis;vesicle fusion	12130530	SNARE (N-ethylmaleimide-sensitive factor attachment protein receptor) complexes are responsible for membrane fusion in the secretory pathway. VAMP-3 and VAMP-8 form ternary SNARE complexes with platelet syntaxin 4 and are required for platelet granule secretion.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Synaptosomal-associated protein 23;Syntaxin-4;Vesicle-associated membrane protein 8	SNAP23;STX4;VAMP8	None;STX4A;None
8535	ANKRD1-IRF3 complex	Human	None	HEK293 FT cells	Q14653;Q15327	3661;27063	MI:0007-anti tag coimmunoprecipitation	GO:0051607;GO:0002221;GO:0045087;GO:0019221;GO:0032481	defense response to virus;pattern recognition receptor signaling pathway;innate immune response;cytokine-mediated signaling pathway;positive regulation of type I interferon production	36.25.16.01	innate immune response (invertebrates and vertebrates)	29371118	None	ANKRD1 expression is reduced in human peripheral blood mononuclear cells from patients with eczema herpeticum, a complication of atopic dermatitis. Upon infection with herpes simplex virus-1 the expression of  ANKRD1 is significantly induced in patients with atopic dermatitis, but not in patients with eczema herpeticum.	None	Homo sapiens (Human);Homo sapiens (Human)	Interferon regulatory factor 3;Ankyrin repeat domain-containing protein 1	IRF3;ANKRD1	None;C193,CARP,HA1A2
8536	ANKRD1-NFKB1 complex	Human	None	HEK293 FT cells	P19838;Q15327	4790;27063	MI:0007-anti tag coimmunoprecipitation	GO:0019221;GO:0045087;GO:1901222	cytokine-mediated signaling pathway;innate immune response;regulation of NIK/NF-kappaB signaling	36.25.16.01	innate immune response (invertebrates and vertebrates)	29371118	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Nuclear factor NF-kappa-B p105 subunit;Ankyrin repeat domain-containing protein 1	NFKB1;ANKRD1	None;C193,CARP,HA1A2
8537	ISGF3 complex	Human	Interferon-stimulated gene factor 3 transcription complex; IRF9-STAT1-STAT2 complex	HeLa cells	P42224;P52630;Q00978	6772;6773;10379	MI:0071-molecular sieving;MI:0430-nucleic acid uv cross-linking assay;MI:0006-anti bait coimmunoprecipitation	GO:0051607;GO:0045087;GO:0006954;GO:0005634;GO:0045893;GO:0071357;GO:0035455;GO:0007259;GO:0019048	defense response to virus;innate immune response;inflammatory response;nucleus;positive regulation of DNA-templated transcription;cellular response to type I interferon;response to interferon-alpha;receptor signaling pathway via JAK-STAT;modulation by virus of host process	36.25.16.01;36.25.16.07;70.10;11.02.03.04.01;30.01.05.01.01	innate immune response (invertebrates and vertebrates);inflammatory response;nucleus;transcription activation;JAK-STAT cascade	7537377	The ISGF3 complex binds to IFN stimulated response elements (ISRE) on the DNA to activate the transcription of interferon stimulated genes. IRF9 (p48) and Stat1:2 heterodimer do not associate stably in the absence of DNA (PMID: 8943351). Viruses have evolved several strategies to evade the immune system of the host. Adenovirus infection inhibits the formation of the ISGF3 complex, thereby preventing the expression of genes involved in the antiviral immune response (PMID: 1652751).	None	A heterodimer of Stat2 and either Stat1alpha or Stat1beta plus p48 (IRF9) constitutes ISGF3 (PMID: 7537377).	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Signal transducer and activator of transcription 1-alpha/beta;Signal transducer and activator of transcription 2;Interferon regulatory factor 9	STAT1;STAT2;IRF9	None;None;ISGF3G
8540	TANK-TBK1-TRAF3 complex	Human	None	HEK293 cells	Q13114;Q92844;Q9UHD2	7187;10010;29110	MI:0007-anti tag coimmunoprecipitation	GO:0032496;GO:0045087;GO:0042742	response to lipopolysaccharide;innate immune response;defense response to bacterium	36.25.16.01	innate immune response (invertebrates and vertebrates)	17823124	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	TNF receptor-associated factor 3;TRAF family member-associated NF-kappa-B activator;Serine/threonine-protein kinase TBK1	TRAF3;TANK;TBK1	CAP-1 CRAF1 TRAFAMN;ITRAF TRAF2;NAK
8541	IKBKE-TBK1 complex	Human	TBK1-IKKepsilon complex	HEK293 cells	Q14164;Q9UHD2	9641;29110	MI:0007-anti tag coimmunoprecipitation	GO:0045087;GO:0051607;GO:0039529;GO:0002221;GO:0032481;GO:0019048	innate immune response;defense response to virus;RIG-I signaling pathway;pattern recognition receptor signaling pathway;positive regulation of type I interferon production;modulation by virus of host process	36.25.16.01	innate immune response (invertebrates and vertebrates)	19380580	Viruses have evolved several strategies to evade the immune system of the host. SARS coronavirus M protein impedes the formation of the TBK1-IKKepsilon complex thereby inhibiting phosphorylation of IRF3 necessary for the production of interferon beta.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Inhibitor of nuclear factor kappa-B kinase subunit epsilon;Serine/threonine-protein kinase TBK1	IKBKE;TBK1	IKKE IKKI KIAA0151;NAK
8542	TANK-TRAF3 complex	Human	TRAF3-TANK complex	HEK293 cells	Q13114;Q92844	7187;10010	MI:0006-anti bait coimmunoprecipitation	GO:0045087;GO:0051607;GO:0002221;GO:0039529;GO:0032481;GO:0019048	innate immune response;defense response to virus;pattern recognition receptor signaling pathway;RIG-I signaling pathway;positive regulation of type I interferon production;modulation by virus of host process	36.25.16.01	innate immune response (invertebrates and vertebrates)	19380580	Viruses have evolved several strategies to evade the immune system of the host. Formation of the TRAF3-TANK complex was blocked in the presence of SARS-CoV M protein to inhibit type I interferon production.	None	None	Homo sapiens (Human);Homo sapiens (Human)	TNF receptor-associated factor 3;TRAF family member-associated NF-kappa-B activator	TRAF3;TANK	CAP-1 CRAF1 TRAFAMN;ITRAF TRAF2
8543	Centriolar subdistal appendage	Human	None	hTERT-RPE1 cells	O00139;Q14203;Q5BJF6;Q5SW79;Q6ZU80;Q7Z7A1;Q8N4C6	3796;1639;4957;9859;145508;11064;51199	MI:0069-mass spectrometry studies of complexes;MI:0416-fluorescence microscopy	GO:0060271;GO:0007224	cilium assembly;smoothened signaling pathway	30.05.02.16	hedgehog-dependent signalling pathway	27818179	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Kinesin-like protein KIF2A;Dynactin subunit 1;Outer dense fiber protein 2;Centrosomal protein of 170 kDa;Centrosomal protein of 128 kDa;Centriolin;Ninein	KIF2A;DCTN1;ODF2;CEP170;CEP128;CNTRL;NIN	KIF2 KNS2;None;None;FAM68A,KAB,KIAA0470;C14orf145,C14orf61;CEP1,CEP110;KIAA1565
8544	TANK-TBK1-IRF3 complex	Human	None	HEK293T cells	Q14653;Q92844;Q9UHD2	3661;10010;29110	MI:0007-anti tag coimmunoprecipitation	GO:0060338;GO:0051607;GO:0032606	regulation of type I interferon-mediated signaling pathway;defense response to virus;type I interferon production	None	None	17327220	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Interferon regulatory factor 3;TRAF family member-associated NF-kappa-B activator;Serine/threonine-protein kinase TBK1	IRF3;TANK;TBK1	None;ITRAF TRAF2;NAK
8546	ITGA4-ITGB7 complex	Human	alpha4-beta7 integrin complex	mucosal lymphocytes	P13612;P26010	3676;3695	MI:0019-coimmunoprecipitation	GO:0008305;GO:0007155	integrin complex;cell adhesion	34.07	cell adhesion	1542691	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Integrin alpha-4;Integrin beta-7	ITGA4;ITGB7	CD49D;None
8547	IKBKE-TANK-TBK1-TRAF3 complex	Human	TBK1-IKKepsilon-TRAF3-TANK complex	HEK293 cells	Q13114;Q14164;Q92844;Q9UHD2	7187;9641;10010;29110	MI:0006-anti bait coimmunoprecipitation	GO:0051607;GO:0045087;GO:0002221;GO:0032481;GO:0043331;GO:0039529;GO:0019048	defense response to virus;innate immune response;pattern recognition receptor signaling pathway;positive regulation of type I interferon production;response to dsRNA;RIG-I signaling pathway;modulation by virus of host process	36.25.16.01	innate immune response (invertebrates and vertebrates)	19380580	Viruses have evolved several strategies to evade the immune system of the host. TBK1 can form a complex with TRAF3, TANK and IKKepsilon in the cytoplasm, which is a crucial step in the IRF3 activation. SARS-CoV-2 M protein interacts with TBK1, and induces TBK1 degradation via K48-linked ubiquitination. Reduced TBK1 protein levels further impair the formation of the TRAF3-TANK-TBK1-IKKepsilon complex leading to inhibition of IFN-I production. (PMID: 34084167; 19380580)	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	TNF receptor-associated factor 3;Inhibitor of nuclear factor kappa-B kinase subunit epsilon;TRAF family member-associated NF-kappa-B activator;Serine/threonine-protein kinase TBK1	TRAF3;IKBKE;TANK;TBK1	CAP-1 CRAF1 TRAFAMN;IKKE IKKI KIAA0151;ITRAF TRAF2;NAK
8548	ITGA3-ITGB5 complex	Human	alpha3-beta5 integrin complex	osteoblastic cells	P18084;P26006	3693;3675	MI:0019-coimmunoprecipitation	GO:0008305;GO:0007155	integrin complex;cell adhesion	34.07	cell adhesion	16878156	The direct biological implication of integrin alpha3beta1 on the surface of transformed cells increased migratory capacity of these cells contributing to the acquisition of malignant phenotype and may represent a novel therapeutic target. (PMID:16878156)	None	None	Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-5;Integrin alpha-3	ITGB5;ITGA3	None;MSK18
8549	ITGA3-ITGB4 complex	Human	alpha3-beta4 integrin complex	osteoblastic cells	P16144;P26006	3691;3675	MI:0019-coimmunoprecipitation	GO:0008305;GO:0007155	integrin complex;cell adhesion	34.07	cell adhesion	16878156	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Integrin beta-4;Integrin alpha-3	ITGB4;ITGA3	None;MSK18
8550	DDX58-MAP3K14-MAVS complex	Human	RIG-I-MAVS-NIK complex; DDX58-MAVS-MAP3K14 complex; DDX58-MAP3K14-MAVS complex	HEK293 cells	O95786;Q7Z434;Q99558	23586;57506;9020	MI:0007-anti tag coimmunoprecipitation	GO:0045087;GO:0051607;GO:0002221;GO:0039529;GO:0051092;GO:0043331;GO:0032481	innate immune response;defense response to virus;pattern recognition receptor signaling pathway;RIG-I signaling pathway;positive regulation of NF-kappaB transcription factor activity;response to dsRNA;positive regulation of type I interferon production	36.25.16.01	innate immune response (invertebrates and vertebrates)	18550535	RIG-I is the initial intracellular sensor for respiratory syncytial virus (RSV) infection (PMID:17108032).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Antiviral innate immune response receptor RIG-I;Mitochondrial antiviral-signaling protein;Mitogen-activated protein kinase kinase kinase 14	DDX58;MAVS;MAP3K14	None;IPS1,KIAA1271,VISA;NIK
8551	DDX58-MAVS complex	Human	RIG-I-MAVS complex	HEK293T cells	O95786;Q7Z434	23586;57506	MI:0007-anti tag coimmunoprecipitation	GO:0051607;GO:0045087;GO:0043331;GO:0039529;GO:0032481;GO:0002221;GO:0051092;GO:0019048	defense response to virus;innate immune response;response to dsRNA;RIG-I signaling pathway;positive regulation of type I interferon production;pattern recognition receptor signaling pathway;positive regulation of NF-kappaB transcription factor activity;modulation by virus of host process	36.25.16.01	innate immune response (invertebrates and vertebrates)	35075101	Viruses have evolved several strategies to evade the immune system of the host. NSP5, the main protease of SARS-CoV-2, disrupts RIG-I-MAVS complex formation to attenuate the RIG-I-mediated antiviral immunity (PMID:35075101). Influenza A virus NS1 protein also suppresses the formation of RIG-I-MAVS complex by inhibiting RIG-I ubiquitination (PMID:19454348). Sendai virus 3C protein suppresses RIG-I signaling by disruption of the RIG-I-MAVS complex and IRF3 nuclear translocation (PMID:20519382).	None	None	Homo sapiens (Human);Homo sapiens (Human)	Antiviral innate immune response receptor RIG-I;Mitochondrial antiviral-signaling protein	DDX58;MAVS	None;IPS1,KIAA1271,VISA
8552	IFI16-H2B-BRCA1 complex	Human	None	HMVEC-d cells	P38398;Q16666;Q8N257	672;3428;128312	MI:0006-anti bait coimmunoprecipitation	GO:0051607;GO:0045087;GO:0005634;GO:0005737;GO:0045893;GO:0032481;GO:1990784;GO:0032728	defense response to virus;innate immune response;nucleus;cytoplasm;positive regulation of DNA-templated transcription;positive regulation of type I interferon production;response to dsDNA;positive regulation of interferon-beta production	36.25.16.01;70.10;70.03;11.02.03.04.01	innate immune response (invertebrates and vertebrates);nucleus;cytoplasm;transcription activation	27764250	During infection with Kaposi's sarcoma-associated herpesvirus, nuclear H2B associated with IFI16 and BRCA1, translocates to the cytoplasm and associates with cGAS-STING leading to TBK1- and IRF3-dependent IFN-beta production.	None	Since the authors did not specify H2B, we used Histone H2B type 1-C/E/F/G/I.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Breast cancer type 1 susceptibility protein;Gamma-interferon-inducible protein 16;Histone H2B type 3-B	BRCA1;IFI16;H2BC26	RNF53;IFNGIP1;H2BU1 HIST3H2BB
8553	IFI16-BRCA1 complex	Human	BRCA1-IFI16 complex	HMVEC-d cells	P46736;Q16666	79184;3428	MI:0019-coimmunoprecipitation	GO:0045087;GO:0051607;GO:1990784;GO:0005634;GO:0060338	innate immune response;defense response to virus;response to dsDNA;nucleus;regulation of type I interferon-mediated signaling pathway	36.25.16.01;70.10	innate immune response (invertebrates and vertebrates);nucleus	26121674	IFI16-BRCA1 complex formation increases in the presence of nuclear viral genomes during de novo infection with Kaposi's sarcoma-associated herpesvirus, Epstein-Barr virus, and herpes simplex virus type-1 leading to IFI16-inflammasome formation.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Lys-63-specific deubiquitinase BRCC36;Gamma-interferon-inducible protein 16	BRCC3;IFI16	BRCC36 C6.1A CXorf53;IFNGIP1
8554	CALM1-CCP110-CETN2 complex	Human	CAM-CP110-CETN complex	293T cells	O43303;P0DP23;P41208	9738;801;1069	MI:0019-coimmunoprecipitation;MI:0091-chromatography technology	GO:0007098;GO:0005813	centrosome cycle;centrosome	10.03.05.01;70.05	spindle pole body/centrosome and microtubule cycle;centrosome	16760425	The authors believe  that CCP110 forms very large complexes with centrin, CaM, and a cohort of uncharacterized proteins.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Centriolar coiled-coil protein of 110 kDa;Calmodulin-1;Centrin-2	CCP110;CALM1;CETN2	CEP110 CP110 KIAA0419;CALM CAM CAM1;CALT CEN2
8555	TIM22 core complex (AGK, TIMM22, TIMM29), mitochondrial	Human	None	HEK293T mitochondria	Q53H12;Q9BSF4;Q9Y584	55750;90580;29928	MI:0047-far western blotting;MI:0069-mass spectrometry studies of complexes;MI:0276-blue native page	GO:0071806;GO:0005743;GO:0042721;GO:0005739;GO:0006626;GO:0006839	protein transmembrane transport;mitochondrial inner membrane;TIM22 mitochondrial import inner membrane insertion complex;mitochondrion;protein targeting to mitochondrion;mitochondrial transport	70.16.05;70.16;20.09.04	mitochondrial inner membrane;mitochondrion;mitochondrial transport	33125709	The translocase of the inner membrane 22 (TIM22) is a multi-subunit molecular machine specialized for the translocation of hydrophobic, multi-transmembrane-spanning proteins with internal targeting signals into the inner mitochondrial membrane. Chaperone complex contact sites within TIM29, TIM22 and AGK indicate that the small TIM chaperones have multiple docking sites within the core complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Acylglycerol kinase, mitochondrial;Mitochondrial import inner membrane translocase subunit Tim29;Mitochondrial import inner membrane translocase subunit Tim22	AGK;TIMM29;TIMM22	MULK;c19orf52;TEX4 TIM22
8556	Small TIM chaperone complex (TIMM9, TIMM10, TIMM10B), mitochondrial	Human	Small TIM chaperone complex (TIM9, TIM10A, TIM10B), mitochondrial	HEK293T mitochondria	P62072;Q9Y5J6;Q9Y5J7	26519;26515;26520	MI:0047-far western blotting;MI:0069-mass spectrometry studies of complexes	GO:0042719;GO:0005758;GO:0006839	mitochondrial intermembrane space protein transporter complex;mitochondrial intermembrane space;mitochondrial transport	70.16.03;20.09.04	mitochondrial intermembrane space;mitochondrial transport	33125709	Upon translocation through the TOM complex, the precursor protein is bound by the small TIM chaperone complexes that maintain the precursor in an import-competent state, by preventing aggregation of the hydrophobic transmembrane segments. The precursor is then shuttled across the aqueous intermembrane space to the TIM22 complex for insertion into the inner mitochondrial membrane.	None	Humans have two isoforms of TIM10, TIM10A  and TIM10B. TIM10A, like its yeast counterpart, forms a hexameric complex with TIM9 and is herein referred to simply as TIM10. In contrast, TIM10B remains constitutively associated with the core TIM22 complex and so it was proposed to be the functional human homolog of the yeast Tim12 protein, the docking site for the small TIM chaperone complex.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mitochondrial import inner membrane translocase subunit Tim10;Mitochondrial import inner membrane translocase subunit Tim10 B;Mitochondrial import inner membrane translocase subunit Tim9	TIMM10;TIMM10B;TIMM9	TIM10;FXC1 TIM9B TIMM9B;TIM9 TIM9A TIMM9A
8557	TIM22 holo-complex (AGK, TIMM9, TIMM10, TIMM10B, TIMM22, TIMM29), mitochondrial	Human	Small TIM chaperone - TIM22 core complex, mitochondrial; mitochondrial intermembrane space protein transporter complex	HEK293T mitochondria	P62072;Q53H12;Q9BSF4;Q9Y584;Q9Y5J6;Q9Y5J7	26519;55750;90580;29928;26515;26520	MI:0019-coimmunoprecipitation;MI:0047-far western blotting;MI:0276-blue native page	GO:0005743;GO:0042721;GO:0042719;GO:0005758;GO:0005739;GO:0006626;GO:0015031;GO:0006839	mitochondrial inner membrane;TIM22 mitochondrial import inner membrane insertion complex;mitochondrial intermembrane space protein transporter complex;mitochondrial intermembrane space;mitochondrion;protein targeting to mitochondrion;protein transport;mitochondrial transport	70.16.05;70.16.03;70.16;20.01.10;20.09.04	mitochondrial inner membrane;mitochondrial intermembrane space;mitochondrion;protein transport;mitochondrial transport	33125709	The translocase of the inner membrane 22 (TIM22) is a multisubunit molecular machine specialized for the translocation of hydrophobic, multi-transmembrane-spanning proteins with internal targeting signals into the inner mitochondrial membrane. The TIM22 core complex has multiple interaction sites for the small TIM chaperone complex. Intermolecular crosslinks were detected between the TIM9 and TIM10 proteins, but also between the small TIMs and each of the core TIM22 components TIM29, TIM22 and AGK.	None	Humans have two isoforms of TIM10, TIM10A and TIM10B. TIM10A, like its yeast counterpart, forms a hexameric complex with TIM9 and is herein referred to simply as TIM10. In contrast, TIM10B remains constitutively associated with the core TIM22 complex and so it was proposed to be the functional human homolog of the yeast Tim12 protein, the docking site for the small TIM chaperone complex.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mitochondrial import inner membrane translocase subunit Tim10;Acylglycerol kinase, mitochondrial;Mitochondrial import inner membrane translocase subunit Tim29;Mitochondrial import inner membrane translocase subunit Tim22;Mitochondrial import inner membrane translocase subunit Tim10 B;Mitochondrial import inner membrane translocase subunit Tim9	TIMM10;AGK;TIMM29;TIMM22;TIMM10B;TIMM9	TIM10;MULK;c19orf52;TEX4 TIM22;FXC1 TIM9B TIMM9B;TIM9 TIM9A TIMM9A
8559	TIM23(motor) subcomplex (DNAJC19, PAM16), mitochondrial	Human	DNAJC19-PAM16 subcomplex; MAGMAS-TIM14 subcomplex; TIMM14-TIMM16 subcomplex; PAM subcomplex DNAJC19, PAM16)(	HEK293T mitochondria	Q96DA6;Q9Y3D7	131118;51025	MI:0047-far western blotting;MI:0096-pull down	GO:0005743;GO:0030150;GO:0001405;GO:0005739;GO:0006839;GO:0006626	mitochondrial inner membrane;protein import into mitochondrial matrix;PAM complex, Tim23 associated import motor;mitochondrion;mitochondrial transport;protein targeting to mitochondrion	70.16.05;70.16;20.09.04	mitochondrial inner membrane;mitochondrion;mitochondrial transport	20053669	Magmas localizes into mitochondria and is peripherally associated with inner mitochondrial membrane in humans. Magmas forms a stable subcomplex with J-protein Pam18 or DnaJC19 through its C-terminal region and is tethered to TIM23 complex. It is proposed that the mutations resulting in decreased stability of functional Magmas-DnaJC19 subcomplex at human TIM23 channel leads to impaired protein import and cellular respiration in DCM patients (PMID:20053669). The TIM23 complex is anchored to the inner mitochondrial membrane (IMM) and exists as a hetero-oligomeric complex, composed of various subunits. It consists of an integral membrane embedded core complex as well as an import motor. The core complex contains three essential subunits named TIM17A/B, TIM23, and TIM50. Additionally, the membrane-embedded part has the two non-essential subunits TIM21 and ROMO1. The import motor, also known as the presequence translocase-associated motor (PAM) complex, drives translocation across the IMM, aided by ATP hydrolysis, and consists of TIM44, mtHSP70, DNAJC15/19, TIM16, and GRPEL1/2 (PMID: 34064758).	In humans, absence of a functional DnaJC19 leads to dilated cardiac myophathic syndrome (DCM), a genetic disorder with characteristic features of cardiac myophathy and neurodegeneration.	None	Homo sapiens (Human);Homo sapiens (Human)	Mitochondrial import inner membrane translocase subunit TIM14;Mitochondrial import inner membrane translocase subunit TIM16	DNAJC19;PAM16	TIM14 TIMM14;MAGMAS TIM16 TIMM16
8560	Pericentrin complex	Human	None	RPE-1 cells	O95613;Q13099;Q13563;Q8IY31;Q9NWB7	5116;8100;5311;90410;55081	MI:0019-coimmunoprecipitation;MI:0416-fluorescence microscopy	GO:0036064;GO:0060271	ciliary basal body;cilium assembly	None	None	15337773	None	None	The Pcnt antibodies used in the study recognize both small, Pcnt A and large, Pcnt B isoforms.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Pericentrin;Intraflagellar transport protein 88 homolog;Polycystin-2;Intraflagellar transport protein 20 homolog;Intraflagellar transport protein 57 homolog	PCNT;IFT88;PKD2;IFT20;IFT57	KIAA0402 PCNT2;TG737 TTC10;TRPP2;None;DERP8 ESRRBL1 HIPPI
8561	TNFR1 signaling complex, TNF-induced	Human	None	A549 cells, stimulated with TNF	O14920;O15111;O43318;O43464;P01375;P19438;P21580;Q12933;Q13489;Q13490;Q13546;Q14164;Q15025;Q15628;Q8NFZ5;Q92844;Q96EP0;Q9BYM8;Q9H0F6;Q9NQC7;Q9NYJ8;Q9UHD2;Q9UM82;Q9Y6K9	3551;1147;6885;27429;7124;7132;7128;7186;330;329;8737;9641;10318;8717;79155;10010;55072;10616;81858;1540;23118;29110;9825;8517	MI:0007-anti tag coimmunoprecipitation	GO:0016567;GO:0010803;GO:0060548;GO:0050727;GO:0034612	protein ubiquitination;regulation of tumor necrosis factor-mediated signaling pathway;negative regulation of cell death;regulation of inflammatory response;response to tumor necrosis factor	14.07.05	modification by ubiquitination, deubiquitination	30420664	TBK1 and IKKepsilon play an important role in in preventing TNF-induced cell death. The activity of the LUBAC complex enables TBK1 and IKKepsilon recruitment to and activation at the TNF receptor 1 signalling complex.	None	The abundancy of c-IAP2 in this complex is lower than that of c-IAP1.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Inhibitor of nuclear factor kappa-B kinase subunit beta;Inhibitor of nuclear factor kappa-B kinase subunit alpha;Mitogen-activated protein kinase kinase kinase 7;Serine protease HTRA2, mitochondrial;Tumor necrosis factor;Tumor necrosis factor receptor superfamily member 1A;Tumor necrosis factor alpha-induced protein 3;TNF receptor-associated factor 2;Baculoviral IAP repeat-containing protein 3;Baculoviral IAP repeat-containing protein 2;Receptor-interacting serine/threonine-protein kinase 1;Inhibitor of nuclear factor kappa-B kinase subunit epsilon;TNFAIP3-interacting protein 1;Tumor necrosis factor receptor type 1-associated DEATH domain protein;TNFAIP3-interacting protein 2;TRAF family member-associated NF-kappa-B activator;E3 ubiquitin-protein ligase RNF31;RanBP-type and C3HC4-type zinc finger-containing protein 1;Sharpin;Ubiquitin carboxyl-terminal hydrolase CYLD;TGF-beta-activated kinase 1 and MAP3K7-binding protein 2;Serine/threonine-protein kinase TBK1;Spermatogenesis-associated protein 2;NF-kappa-B essential modulator	IKBKB;CHUK;MAP3K7;HTRA2;TNF;TNFRSF1A;TNFAIP3;TRAF2;BIRC3;BIRC2;RIPK1;IKBKE;TNIP1;TRADD;TNIP2;TANK;RNF31;RBCK1;SHARPIN;CYLD;TAB2;TBK1;SPATA2;IKBKG	IKKB;IKKA TCF16;TAK1;OMI PRSS25;TNFA TNFSF2;TNFAR, TNFR1;OTUD7C;TRAP3;API2 MIHC RNF49;API1 MIHB RNF48;RIP, RIP1;IKKE IKKI KIAA0151;KIAA0113 NAF1;None;ABIN2 FLIP1;ITRAF TRAF2;ZIBRA;C20orf18 RNF54 UBCE7IP3 XAP3 XAP4;SIPL1;CYLD1 KIAA0849;KIAA0733, MAP3K7IP2;NAK;KIAA0757, PD1;FIP3, NEMO
8562	LUBAC-SPATA2-CYLD complex	Human	None	K562 cells; A549 cells	Q96EP0;Q9BYM8;Q9H0F6;Q9NQC7;Q9UM82	55072;10616;81858;1540;9825	MI:0676-tandem affinity purification	GO:0032434;GO:0097039;GO:0010941;GO:0043122;GO:0010803;GO:0070432	regulation of proteasomal ubiquitin-dependent protein catabolic process;protein linear polyubiquitination;regulation of cell death;regulation of I-kappaB kinase/NF-kappaB signaling;regulation of tumor necrosis factor-mediated signaling pathway;regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway	None	None	27545878	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase RNF31;RanBP-type and C3HC4-type zinc finger-containing protein 1;Sharpin;Ubiquitin carboxyl-terminal hydrolase CYLD;Spermatogenesis-associated protein 2	RNF31;RBCK1;SHARPIN;CYLD;SPATA2	ZIBRA;C20orf18 RNF54 UBCE7IP3 XAP3 XAP4;SIPL1;CYLD1 KIAA0849;KIAA0757, PD1
8563	COA3-HSPA9-TIMM44-TIM23(sort) complex, mitochondrial	Human	MITRAC12-mtHSP70-TIM44-TIM23(sort) complex, mitochondrial	HEK293T cell line	O14925;O43615;P38646;P60602;Q3ZCQ8;Q99595;Q9BVV7;Q9Y2R0	100287932;10469;3313;140823;92609;10440;29090;28958	MI:0019-coimmunoprecipitation;MI:0069-mass spectrometry studies of complexes;MI:0113-western blot	GO:0005744;GO:0031072;GO:0001405;GO:0005743;GO:0005739;GO:0006626;GO:0006839	TIM23 mitochondrial import inner membrane translocase complex;heat shock protein binding;PAM complex, Tim23 associated import motor;mitochondrial inner membrane;mitochondrion;protein targeting to mitochondrion;mitochondrial transport	70.16.05;70.16;20.09.04	mitochondrial inner membrane;mitochondrion;mitochondrial transport	30598479	Expected subunits of the TIM23 complex such as TIM17A, TIM17B, and TIM44 with TIM23, TIM21, and TIM50 were identified. Moreover, in case of TIM21FLAG, subunits of the MITRAC assembly intermediate were also identified. This was expected, since TIM21 shuttles between the translocase and MITRAC assembly intermediates of COX1. Additionally, in all analyses, a protein named ROMO1 (ROS modulator 1) was identified. ROMO1 was efficiently co-isolated with TIM21FLAG along with TIM50, TIM23, COX1, and MITRAC12.	None	ROMO1 participates in coupling TIM21 to the TIM23 complex. Human TIM21 associates with the TIM23 complex but is dispensable for protein import. In addition, it is a constituent of the MITRAC complex, which represents an assembly intermediate of cytochrome c oxidase. ROMO1 as a translocase constituent with an exceptionally short half-life.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mitochondrial import inner membrane translocase subunit Tim23;Mitochondrial import inner membrane translocase subunit TIM44;Stress-70 protein, mitochondrial;Reactive oxygen species modulator 1;Mitochondrial import inner membrane translocase subunit TIM50;Mitochondrial import inner membrane translocase subunit Tim17-A;Mitochondrial import inner membrane translocase subunit Tim21;Cytochrome c oxidase assembly factor 3 homolog, mitochondrial	TIMM23;TIMM44;HSPA9;ROMO1;TIMM50;TIMM17A;TIMM21;COA3	TIM23;MIMT44, TIM44;GRP75 HSPA9B mt-HSP70;C20orf52;TIM50;MIMT17 TIM17 TIM17A TIMM17;C18orf55 TIM21;CCDC56 MITRAC12
8564	IKBKG-MAVS-TBK1 complex	Human	NEMO-TBK1-MAVS complex	HEK293 cells, infected with Sendai virus	Q7Z434;Q9UHD2;Q9Y6K9	57506;29110;8517	MI:0007-anti tag coimmunoprecipitation	GO:0051607;GO:0045087;GO:0002221;GO:0039529;GO:0032481;GO:0009615	defense response to virus;innate immune response;pattern recognition receptor signaling pathway;RIG-I signaling pathway;positive regulation of type I interferon production;response to virus	36.25.16.01	innate immune response (invertebrates and vertebrates)	23028469	Upon infection with Sendai virus, TBK1 is ubiquitinated reulting in TBK1-NEMO complex formation. This complex assembles with MAVS leading to activation of TBK1 kinase activity and phosphorylation of the transcription factor, interferon response factor 3 which triggers the antiviral immune response.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mitochondrial antiviral-signaling protein;Serine/threonine-protein kinase TBK1;NF-kappa-B essential modulator	MAVS;TBK1;IKBKG	IPS1,KIAA1271,VISA;NAK;FIP3, NEMO
8565	IKBKE-IRF3-TANK-TBK1 complex	Human	TBK1-IKKepsilon-TANK-IRF3 complex	HEK293T cells	Q14164;Q14653;Q92844;Q9UHD2	9641;3661;10010;29110	MI:0007-anti tag coimmunoprecipitation	GO:0051607;GO:0045087;GO:0002221;GO:0039529;GO:0032481;GO:0019048	defense response to virus;innate immune response;pattern recognition receptor signaling pathway;RIG-I signaling pathway;positive regulation of type I interferon production;modulation by virus of host process	36.25.16.01	innate immune response (invertebrates and vertebrates)	28487378	Viruses have evolved several strategies to evade the immune system of the host. Encephalomyocarditis virus protein 3C inhibits type I IFN signaling by disrupting the formation of the TANK-TBK1-IKKepsilon-IRF3 complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Inhibitor of nuclear factor kappa-B kinase subunit epsilon;Interferon regulatory factor 3;TRAF family member-associated NF-kappa-B activator;Serine/threonine-protein kinase TBK1	IKBKE;IRF3;TANK;TBK1	IKKE IKKI KIAA0151;None;ITRAF TRAF2;NAK
8566	TIM23(sort) complex (ROMO1, TIMM17A, TIMM21, TIMM23, TIMM50), mitochondrial	Human	TIM23 subcomplex	HEK293T cell line	O14925;P60602;Q3ZCQ8;Q99595;Q9BVV7	100287932;140823;92609;10440;29090	MI:0019-coimmunoprecipitation;MI:0069-mass spectrometry studies of complexes	GO:0005744;GO:0015031;GO:0005743;GO:0005739;GO:0006626;GO:0006839	TIM23 mitochondrial import inner membrane translocase complex;protein transport;mitochondrial inner membrane;mitochondrion;protein targeting to mitochondrion;mitochondrial transport	20.01.10;70.16.05;70.16;20.09.04	protein transport;mitochondrial inner membrane;mitochondrion;mitochondrial transport	30598479	Expected subunits of the TIM23 complex such as TIM17A, TIM17B, and TIM44 with TIM23, TIM21, and TIM50 were identified. Additionally, in all analyses, a protein named ROMO1 (ROS modulator 1) was identified.	None	ROMO1 participates in coupling TIM21 to the TIM23 complex. Human TIM21 associates with the TIM23 complex but is dispensable for protein import. In addition, it is a constituent of the MITRAC complex, which represents anassembly intermediate of cytochrome c oxidase. ROMO1 as a translocase constituent with an exceptionally short half-life.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mitochondrial import inner membrane translocase subunit Tim23;Reactive oxygen species modulator 1;Mitochondrial import inner membrane translocase subunit TIM50;Mitochondrial import inner membrane translocase subunit Tim17-A;Mitochondrial import inner membrane translocase subunit Tim21	TIMM23;ROMO1;TIMM50;TIMM17A;TIMM21	TIM23;C20orf52;TIM50;MIMT17 TIM17 TIM17A TIMM17;C18orf55 TIM21
8567	TAK1-TAB1-TAB3 complex	Human	MAP3K7-TAB1-TAB3	Epithelial KB cells; HEK-293 cells	O43318;Q15750;Q8N5C8	6885;10454;257397	MI:0007-anti tag coimmunoprecipitation;MI:0045-experimental interaction detection	GO:0034612;GO:0070555;GO:0050727	response to tumor necrosis factor;response to interleukin-1;regulation of inflammatory response	None	None	14670075	Two distinct TAK1 complexes are present in cells, one comprises TAK1 complexed with TAB1 and TAB2 (CORUM-ID: 2758), and the other TAK1 complexed with TAB1 and TAB3 (CORUM-ID: 8567). (PMID: 14670075)	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mitogen-activated protein kinase kinase kinase 7;TGF-beta-activated kinase 1 and MAP3K7-binding protein 1;TGF-beta-activated kinase 1 and MAP3K7-binding protein 3	MAP3K7;TAB1;TAB3	TAK1;MAP3K7IP1;MAP3K7IP3
8568	MAVS-TRADD complex	Human	TRADD-CARDIF complex	HEK293T cells	Q15628;Q7Z434	8717;57506	MI:0007-anti tag coimmunoprecipitation	GO:0051607;GO:0045087;GO:0051092;GO:0032728;GO:0032481;GO:0002221;GO:0039529	defense response to virus;innate immune response;positive regulation of NF-kappaB transcription factor activity;positive regulation of interferon-beta production;positive regulation of type I interferon production;pattern recognition receptor signaling pathway;RIG-I signaling pathway	36.25.16.01	innate immune response (invertebrates and vertebrates)	18439848	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Tumor necrosis factor receptor type 1-associated DEATH domain protein;Mitochondrial antiviral-signaling protein	TRADD;MAVS	None;IPS1,KIAA1271,VISA
8569	MITRAC complex, mitochondrial	Human	MITRAC assembly	HEK293 cell line	P00395;P00403;P00414;P09669;P13073;P20674;Q15526;Q7KZN9;Q7Z7K0;Q96I36;Q9BVV7;Q9GZY4;Q9P0S2;Q9Y2R0	4512;4513;4514;1345;1327;9377;6834;1355;152100;84987;29090;55744;51241;28958	MI:0047-far western blotting;MI:0069-mass spectrometry studies of complexes;MI:0276-blue native page	GO:0098798;GO:0033617;GO:0032543;GO:0033108;GO:0022904;GO:0005739	mitochondrial protein-containing complex;mitochondrial cytochrome c oxidase assembly;mitochondrial translation;mitochondrial respiratory chain complex assembly;respiratory electron transport chain;mitochondrion	02.11.07;20.01.15;70.16	regulation of electron transport and membrane-associated energy conservation;electron transport;mitochondrion	23260140	Among the specific MITRAC12 interaction partners were central structural complex IV subunits such as COX1, COX3, COX4, COX5A, and COX6C and the assembly factors SURF1, COX15, COX16, as well as c12orf62. c7orf44, a protein product of which has sequence similarity to yeast Coa1 and that was term MITRAC15, as well as CMC1, a protein that is suggested to play a role in copper trafficking in yeast, were also identified. Western blot analyses confirmed interactions with TIM21 and MITRAC15.	Mutations in SURF1 are the most frequent cause of Leigh Syndrome with cytochrome c oxidase deficiency. Mutations in C12orf62, a factor that couples COX I synthesis with cytochrome c oxidase assembly, cause fatal neonatal lactic acidosis.	MITRAC12 is a cytochrome c oxidase assembly factor affecting COX1 translation. The finding that TIM21 also interacts with complex I intermediates points to a more general role of TIM21 in respiratory-chain assembly.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cytochrome c oxidase subunit 1;Cytochrome c oxidase subunit 2;Cytochrome c oxidase subunit 3;Cytochrome c oxidase subunit 6C;Cytochrome c oxidase subunit 4 isoform 1, mitochondrial;Cytochrome c oxidase subunit 5A, mitochondrial;Surfeit locus protein 1;Cytochrome c oxidase assembly protein COX15 homolog;COX assembly mitochondrial protein homolog;Cytochrome c oxidase assembly protein COX14;Mitochondrial import inner membrane translocase subunit Tim21;Cytochrome c oxidase assembly factor 1 homolog;Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial;Cytochrome c oxidase assembly factor 3 homolog, mitochondrial	MT-CO1;MT-CO2;MT-CO3;COX6C;COX4I1;COX5A;SURF1;COX15;CMC1;COX14;TIMM21;COA1;COX16;COA3	COI COXI MTCO1;COII COX2 COXII MTCO2;COIII COXIII MTCO3;None;COX4;None;SURF-1;None;C3orf68;C12orf62;C18orf55 TIM21;C7orf44 MITRAC15;C14orf112;CCDC56 MITRAC12
8570	FADD-MAVS-RIPK1 complex	Human	MAVS-FADD-RIP1 complex; IPS1-FADD-RIP1 complex; CARDIF-FADD-RIP1 complex; FADD-MAVS-RIPK1 complex	HEK293 cells	Q13158;Q13546;Q7Z434	8772;8737;57506	MI:0007-anti tag coimmunoprecipitation	GO:0051607;GO:0032728;GO:0032481;GO:0045087;GO:0039529;GO:0051092;GO:0002221;GO:0043331	defense response to virus;positive regulation of interferon-beta production;positive regulation of type I interferon production;innate immune response;RIG-I signaling pathway;positive regulation of NF-kappaB transcription factor activity;pattern recognition receptor signaling pathway;response to dsRNA	36.25.16.01	innate immune response (invertebrates and vertebrates)	16127453	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	FAS-associated death domain protein;Receptor-interacting serine/threonine-protein kinase 1;Mitochondrial antiviral-signaling protein	FADD;RIPK1;MAVS	MORT1;RIP, RIP1;IPS1,KIAA1271,VISA
8571	Outer dynein arm complex 2	Human	None	HEK293T cells	Q8TE73;Q9GZS0;Q9NYC9;Q9UI46	1767;64446;1770;27019	MI:0019-coimmunoprecipitation	GO:0031514;GO:0036157;GO:0003341	motile cilium;outer dynein arm;cilium movement	None	None	30471718	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Dynein axonemal heavy chain 5;Dynein axonemal intermediate chain 2;Dynein axonemal heavy chain 9;Dynein axonemal intermediate chain 1	DNAH5;DNAI2;DNAH9;DNAI1	DNAHC5 HL1 KIAA1603;None;DNAH17L DNEL1 KIAA0357;None
8572	Amyloid-beta protein 40-42 oligomeric complex	Human	None	cerebral cortex	P05067-PRO_0000000092;P05067-PRO_0000000093	351;351	MI:0019-coimmunoprecipitation	GO:0106003;GO:0048167;GO:0007613	amyloid-beta complex;regulation of synaptic plasticity;memory	None	None	18568035	Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Amyloid-beta precursor protein;Amyloid-beta precursor protein	APP;APP	A4 AD1;A4 AD1
8573	TANK-TRADD-TRAF3 complex	Human	TRADD-TRAF3-TANK complex	HEK293T cells	Q13114;Q15628;Q92844	7187;8717;10010	MI:0007-anti tag coimmunoprecipitation	GO:0045087;GO:0051607;GO:0039529;GO:0032481;GO:0002221	innate immune response;defense response to virus;RIG-I signaling pathway;positive regulation of type I interferon production;pattern recognition receptor signaling pathway	36.25.16.01	innate immune response (invertebrates and vertebrates)	18439848	RIG-I-mediated interferon responses are dependent on a molecular complex that contains at least TRADD, TRAF3, and TANK. This complex acts downstream of Cardif but upstream of TBK1 and IKKepsilon.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	TNF receptor-associated factor 3;Tumor necrosis factor receptor type 1-associated DEATH domain protein;TRAF family member-associated NF-kappa-B activator	TRAF3;TRADD;TANK	CAP-1 CRAF1 TRAFAMN;None;ITRAF TRAF2
8574	IRF7-MYD88 complex	Human	MYD88-IRF7 complex	HEK293T cells; HeLa cells	Q92985;Q99836	3665;4615	MI:0007-anti tag coimmunoprecipitation;MI:0663-confocal microscopy	GO:0002755;GO:0051607;GO:0045087;GO:0045893;GO:0005737;GO:0002224;GO:0002221;GO:0032481	MyD88-dependent toll-like receptor signaling pathway;defense response to virus;innate immune response;positive regulation of DNA-templated transcription;cytoplasm;toll-like receptor signaling pathway;pattern recognition receptor signaling pathway;positive regulation of type I interferon production	36.25.16.01;11.02.03.04.01;70.03	innate immune response (invertebrates and vertebrates);transcription activation;cytoplasm	15492225	Activation of the IFN promoter by the MyD88-IRF-7 complex was further enhanced by TRAF6 and IRAK4.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Interferon regulatory factor 7;Myeloid differentiation primary response protein MyD88	IRF7;MYD88	None;None
8575	IRAK4-MYD88 complex	Human	Myddosome; MyD88-IRAK4 complex	in vitro	Q99836;Q9NWZ3	4615;51135	MI:0069-mass spectrometry studies of complexes;MI:0071-molecular sieving;MI:0114-x-ray crystallography	GO:0002224;GO:0034142;GO:0002221;GO:0045087;GO:0051092;GO:0006952;GO:0002755	toll-like receptor signaling pathway;toll-like receptor 4 signaling pathway;pattern recognition receptor signaling pathway;innate immune response;positive regulation of NF-kappaB transcription factor activity;defense response;MyD88-dependent toll-like receptor signaling pathway	36.25.16.01	innate immune response (invertebrates and vertebrates)	19592493	Receptor clustering is required to initiate signal transduction by the Toll-like receptor 4.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Myeloid differentiation primary response protein MyD88;Interleukin-1 receptor-associated kinase 4	MYD88;IRAK4	None;None
8576	NDC80-ZW10-ZWINT complex	Human	HEC1-ZW10-ZWINT complex	T24 cells; HeLa cells	O14777;O43264;O95229	10403;9183;11130	MI:0019-coimmunoprecipitation;MI:0416-fluorescence microscopy	GO:0007059;GO:0051315;GO:0000776	chromosome segregation;attachment of mitotic spindle microtubules to kinetochore;kinetochore	10.03.04.05	chromosome segregation/division	16732327	In mitotic cells, NDC80 (HEC1) transiently forms complexes with ZWINT and ZW10 in a temporal and spatial manner. HEC1 and ZWINT co-localize at kinetochores beginning at prophase; ZW10 joins them later at prometa-phase. Inhibition of complex formation causes chromosome missegregation, spindle checkpoint failure, and eventually cell death upon cytokinesis.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Kinetochore protein NDC80 homolog;Centromere/kinetochore protein zw10 homolog;ZW10 interactor	NDC80;ZW10;ZWINT	HEC HEC1 KNTC2;None;None
8577	NBAS-RINT1-ZW10-ZWILCH complex	Human	NAG-RINT1-ZW10-ZWILCH complex; NRZ complex	HeLa cells	A2RRP1;O43264;Q6NUQ1;Q9H900	51594;9183;60561;55055	MI:0007-anti tag coimmunoprecipitation	GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	None	None	20462495	The evolutionarily conserved NBAS-RINT1-ZW10-ZWILCH complex likely acts as a tethering complex for retrograde trafficking of COPI vesicles from the Golgi to the endoplasmic reticulum.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	NBAS subunit of NRZ tethering complex;Centromere/kinetochore protein zw10 homolog;RAD50-interacting protein 1;Protein zwilch homolog	NBAS;ZW10;RINT1;ZWILCH	NAG;None;None;None
8578	RAB3IP-TRAPP II complex	Human	RAB3IP-Transport particle protein complex II	RPE-1 cells	O43617;O75865;P0DI81;P48553;Q86SZ2;Q8IUR0;Q8WVR3;Q96Q05;Q96QF0;Q9UL33;Q9Y296;Q9Y5R8	27095;79090;6399;7109;122553;126003;55262;83696;117177;51693;51399;58485	MI:0004-affinity chromatography technology;MI:0019-coimmunoprecipitation;MI:0069-mass spectrometry studies of complexes	GO:0060271;GO:0046907	cilium assembly;intracellular transport	None	None	31467083	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Trafficking protein particle complex subunit 3;Trafficking protein particle complex subunit 6A;Trafficking protein particle complex subunit 2;Trafficking protein particle complex subunit 10;Trafficking protein particle complex subunit 6B;Trafficking protein particle complex subunit 5;Trafficking protein particle complex subunit 14;Trafficking protein particle complex subunit 9;Rab-3A-interacting protein;Trafficking protein particle complex subunit 2-like protein;Trafficking protein particle complex subunit 4;Trafficking protein particle complex subunit 1	TRAPPC3;TRAPPC6A;TRAPPC2;TRAPPC10;TRAPPC6B;TRAPPC5;TRAPPC14;TRAPPC9;RAB3IP;TRAPPC2L;TRAPPC4;TRAPPC1	BET3;None;SEDL;EHOC1,TMEM1;None;None;C7orf43,MAP11;KIAA1882 NIBP;RABIN8;None;SBDN;BET5,MUM2
8579	Metaxin complex (MTX1, MTX2), mitochondrial	Human	None	HeLa mitochondria	O75431;Q13505	10651;4580	MI:0047-far western blotting;MI:0276-blue native page	GO:0008308;GO:0005741;GO:0017038	voltage-gated anion channel activity;mitochondrial outer membrane;protein import	70.16.01	mitochondrial outer membrane	17510655	Metaxins are required for VDAC biogenesis, but not for the import of matrix precursors. Metaxin 2-depleted mitochondria had reduced levels of metaxin 1 and were deficient in import and assembly of VDAC and Tom40. Metaxin 1 and metaxin 2 were found to be present together in an approximately 600 kDa complex that does not include Sam50.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Metaxin-2;Metaxin-1	MTX2;MTX1	None;MTX MTXN
8580	DDX3-IKBKE-IRF3 complex	Human	DDX3-IKKepsilon-IRF3 complex	A549 cells, stimulated with Sendai virus	O00571;Q14164;Q14653	1654;9641;3661	MI:0007-anti tag coimmunoprecipitation	GO:0045087;GO:0002221;GO:0051607;GO:0032481;GO:0032648;GO:0039529	innate immune response;pattern recognition receptor signaling pathway;defense response to virus;positive regulation of type I interferon production;regulation of interferon-beta production;RIG-I signaling pathway	36.25.16.01	innate immune response (invertebrates and vertebrates)	23478265	DDX3 acts as a downstream scaffolding adaptor that links IKKepsilon and IRF3.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	ATP-dependent RNA helicase DDX3X;Inhibitor of nuclear factor kappa-B kinase subunit epsilon;Interferon regulatory factor 3	DDX3X;IKBKE;IRF3	DBX DDX3;IKKE IKKI KIAA0151;None
8581	IKBKE-MAVS-TRAF3 complex	Human	MAVS-TRAF3-IKKepsilon complex; MAVS-TRAF3-IKBKE complex	A549 cells, infected with Sendai virus	Q13114;Q14164;Q7Z434	7187;9641;57506	MI:0006-anti bait coimmunoprecipitation	GO:0032481;GO:0043331;GO:0051607;GO:0002221;GO:0045087;GO:0039529	positive regulation of type I interferon production;response to dsRNA;defense response to virus;pattern recognition receptor signaling pathway;innate immune response;RIG-I signaling pathway	36.25.16.01	innate immune response (invertebrates and vertebrates)	21200404	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	TNF receptor-associated factor 3;Inhibitor of nuclear factor kappa-B kinase subunit epsilon;Mitochondrial antiviral-signaling protein	TRAF3;IKBKE;MAVS	CAP-1 CRAF1 TRAFAMN;IKKE IKKI KIAA0151;IPS1,KIAA1271,VISA
8582	DDX58-TRIM25-YWHAE complex	Human	RIG-I translocon; RIG-I-TRIM25-14-3-3epsilon complex	HEK293 cells, infected with Sendai virus	O95786;P62258;Q14258	23586;7531;7706	MI:0007-anti tag coimmunoprecipitation	GO:0002221;GO:0045087;GO:0039529;GO:0051607;GO:0006612;GO:0032481;GO:0016567	pattern recognition receptor signaling pathway;innate immune response;RIG-I signaling pathway;defense response to virus;protein targeting to membrane;positive regulation of type I interferon production;protein ubiquitination	36.25.16.01;14.07.05	innate immune response (invertebrates and vertebrates);modification by ubiquitination, deubiquitination	22607805	Upon viral RNA recognition RIG-I is redistributed from the cytosol to membranes where it binds the adaptor protein MAVS. This translocation process is catalyzed by the RIG-I-TRIM25-14-3-3epsilon complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Antiviral innate immune response receptor RIG-I;14-3-3 protein epsilon;E3 ubiquitin/ISG15 ligase TRIM25	DDX58;YWHAE;TRIM25	None;None;EFP RNF147 ZNF147
8583	CYLD-DDX58-SDC4 complex	Human	RIG-I-SDC4-CYLD complex	HEK293 cells, HeLa cells, infected with Sendai virus	O95786;P31431;Q9NQC7	23586;6385;1540	MI:0007-anti tag coimmunoprecipitation	GO:1903003;GO:0002221;GO:0045087;GO:0039536;GO:0032688;GO:0032480;GO:0051607	positive regulation of protein deubiquitination;pattern recognition receptor signaling pathway;innate immune response;negative regulation of RIG-I signaling pathway;negative regulation of interferon-beta production;negative regulation of type I interferon production;defense response to virus	36.25.16.01	innate immune response (invertebrates and vertebrates)	27279133	SDC4 recruits CYLD and RIG-I to form a large complex in a perinuclear pattern post viral infection to potentiate the K63-linked deubiquitination of RIG-I and slow down RIG-I-mediated antiviral signalling. This process is necessary for balancing antiviral signaling to avoid deleterious effects on host cells.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Antiviral innate immune response receptor RIG-I;Syndecan-4;Ubiquitin carboxyl-terminal hydrolase CYLD	DDX58;SDC4;CYLD	None;None;CYLD1 KIAA0849
8584	SWSAP1-ZSWIM7 complex	Human	SWS1-SWSAP1 complex; Shu complex	HEK293T cells; HeLa cells	Q19AV6;Q6NVH7	125150;126074	MI:0019-coimmunoprecipitation;MI:0071-molecular sieving;MI:0676-tandem affinity purification	GO:0097196	Shu complex	None	None	21965664	The SWSAP1-ZSWIM7 complex is required for efficient homologous recombination repair in mammalian cells.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Zinc finger SWIM domain-containing protein 7;ATPase SWSAP1	ZSWIM7;SWSAP1	SWS1;C19orf39
8585	MICOS subcomplex (APOO, IMMT), mitochondrial	Human	MICOS subcomplex (MIC23, MIC60), mitochondrial; MIB subcomplex, mitochondrial	HeLa cells	Q16891;Q9BUR5	10989;79135	MI:0019-coimmunoprecipitation;MI:0047-far western blotting	GO:0061617;GO:0042407	MICOS complex;cristae formation	None	None	25781180	Mitochondrial inner membrane folds into cristae, which significantly increase its surface and are important for mitochondrial function. The stability of cristae depends on the mitochondrial contact site (MICOS) complex. In human mitochondria, the inner membrane MICOS complex interacts with the outer membrane sorting and assembly machinery (SAM) complex, to form the mitochondrial intermembrane space bridging complex (MIB). The most important subunits of the mitochondrial intermembrane space bridging complex (MIB) complex in human mitochondria are MIC60/Mitofilin, MIC19/CHCHD3 and an outer membrane component Sam50. ApoO/MIC23 is a subunit of the mitochondrial contact site (MICOS) and MIB complexes. ApoO/MIC23 is detected in the MIB complex after radiolabelled import into mitochondria and coimmunoprecipitates with MIC60/IMMT.	None	None	Homo sapiens (Human);Homo sapiens (Human)	MICOS complex subunit MIC60;MICOS complex subunit MIC26	IMMT;APOO	HMP MIC60 MINOS2;FAM121B MIC23 MIC26
8586	ILF3-RAN-XPO5-ZNF346 complex	Human	ILF3-RAN-XPO5-JAZ complex	HeLa cells	P62826;Q12906;Q9HAV4;Q9UL40	5901;3609;57510;23567	MI:0007-anti tag coimmunoprecipitation	GO:0006611;GO:0006405;GO:0005737;GO:0005634	protein export from nucleus;RNA export from nucleus;cytoplasm;nucleus	70.03;70.10	cytoplasm;nucleus	15254228	ZNF346 (JAZ) is an unusual dsRNA-binding protein that binds its target RNAs with high affinity via C2H2 zinc fingers. It is a nuclear protein at steady state but is highly dynamic within the nucleus and undergoes nucleocytoplasmic shuttling.	None	For the analyses the constitutively active variant RanQ69L was used.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	GTP-binding nuclear protein Ran;Interleukin enhancer-binding factor 3;Exportin-5;Zinc finger protein 346	RAN;ILF3;XPO5;ZNF346	ARA24;DRBF MPHOSPH4 NF90;KIAA1291 RANBP21;JAZ
8587	Mitofilin complex, mitochondrial	Human	MIB subcomplex, mitochondrial	human heart mitochondria	O75431;Q13505;Q16891;Q9BRQ6;Q9NVH1;Q9NX63;Q9Y512	10651;4580;10989;84303;55735;54927;25813	MI:0019-coimmunoprecipitation;MI:0047-far western blotting;MI:0069-mass spectrometry studies of complexes	GO:0005743;GO:0005741;GO:0017038;GO:0006626;GO:0005739;GO:0006839	mitochondrial inner membrane;mitochondrial outer membrane;protein import;protein targeting to mitochondrion;mitochondrion;mitochondrial transport	70.16.05;70.16.01;70.16;20.09.04	mitochondrial inner membrane;mitochondrial outer membrane;mitochondrion;mitochondrial transport	17624330	The mitochondrial inner membrane protein mitofilin exists as a complex with SAM50, metaxins 1 and 2, coiled-coil-helix coiled-coil-helix domain-containing protein 3 and 6 and DnaJC11. Metaxins 1 and 2 along with SAM 50 protein have been characterized as outer membrane proteins. Metaxins 1 and 2 locate on the cytosol side of the outer membrane and serve in protein precursor import into mitochondria. Metaxin 2 is peripherally associated with mitochondrial outer membrane by means of its interaction with membrane-bound metaxin 1 protein. The functional role of this new complex is uncertain. However, a role in protein import related to maintenance of mitochondrial structure is suggested as mitofilin helps regulate mitochondrial morphology and at least four of the associated proteins (metaxins 1 and 2, SAM50 and CHCHD3) have been implicated in protein import, while DnaJC11 is a chaperone-like protein that may have a similar role (PMID:17624330). SAM50 is a critical stabilizing protein of the MIB complex responsible for protein transport, assembly of respiratory chain complexes and regulation of cristae integrity (PMID:34385433).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Metaxin-2;Metaxin-1;MICOS complex subunit MIC60;MICOS complex subunit MIC25;DnaJ homolog subfamily C member 11;MICOS complex subunit MIC19;Sorting and assembly machinery component 50 homolog	MTX2;MTX1;IMMT;CHCHD6;DNAJC11;CHCHD3;SAMM50	None;MTX MTXN;HMP MIC60 MINOS2;CHCM1 MIC25;None;MIC19, MINOS3;SAM50
8588	DDX58-MAVS-STING1 complex	Human	RIG-I-MAVS-STING complex; RIG-I-VISA-MITA complex; DDX58-TMEM17-MAVS complex	HEK293 cells, infected with SeV	O95786;Q7Z434;Q86WV6	23586;57506;340061	MI:0007-anti tag coimmunoprecipitation	GO:0045087;GO:0002221;GO:0051607;GO:0032728;GO:0032481;GO:0039529	innate immune response;pattern recognition receptor signaling pathway;defense response to virus;positive regulation of interferon-beta production;positive regulation of type I interferon production;RIG-I signaling pathway	36.25.16.01	innate immune response (invertebrates and vertebrates)	18818105	RIG-I is recruited to the VISA-MITA complex on mitochondria upon viral infection. MITA and VISA are constitutively localized to the outer membrane of mitochondria as a complex also in uninfected cells.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Antiviral innate immune response receptor RIG-I;Mitochondrial antiviral-signaling protein;Stimulator of interferon genes protein	DDX58;MAVS;STING1	None;IPS1,KIAA1271,VISA;ERIS MITA STING TMEM173
8589	IRF7-MYD88-TRAF6 complex	Human	MyD88-TRAF6-IRF7 complex	HEK293 cells	Q92985;Q99836;Q9Y4K3	3665;4615;7189	MI:0007-anti tag coimmunoprecipitation	GO:0032727;GO:0045087;GO:0002221;GO:0002224;GO:0051607;GO:0032481	positive regulation of interferon-alpha production;innate immune response;pattern recognition receptor signaling pathway;toll-like receptor signaling pathway;defense response to virus;positive regulation of type I interferon production	36.25.16.01	innate immune response (invertebrates and vertebrates)	15361868	TLR-mediated IFN-alpha production requires the formation of a complex consisting of MyD88, TRAF6 and IRF7.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Interferon regulatory factor 7;Myeloid differentiation primary response protein MyD88;TNF receptor-associated factor 6	IRF7;MYD88;TRAF6	None;None;RNF85
8590	MIA complex (AIFM1, CHCHD4), mitochondrial	Human	AIF-MIA40 Complex	human cervical cancer cells, U2OS cells	O95831;Q8N4Q1	9131;131474	MI:0019-coimmunoprecipitation;MI:0047-far western blotting;MI:0069-mass spectrometry studies of complexes	GO:0033108;GO:0045041;GO:0005758;GO:0006457;GO:0006839;GO:0005739;GO:0006626	mitochondrial respiratory chain complex assembly;protein import into mitochondrial intermembrane space;mitochondrial intermembrane space;protein folding;mitochondrial transport;mitochondrion;protein targeting to mitochondrion	70.16.03;14.01;20.09.04;70.16	mitochondrial intermembrane space;protein folding and stabilization;mitochondrial transport;mitochondrion	26004228	AIF interacts with CHCHD4/MIA40, a regulator of the mitochondrial intermembrane space (IMS) import machinery and regulates specific respiratory chain complexes by acting upstream of CHCHD4. AIF is indispensable for translation-coupled mitochondrial import of CHCHD4 (PMID:26004228). MIA40 exists in the IMS as a soluble protein in higher eukaryotes. The evolutionary advantage of the interaction between CHCHD4 and AIF is not understood, but the data published so far indicate that AIF is needed for the co-translational import of CHCHD4 in the IMS (PMID: 33921425).	In humans, mutations in AIF manifest as familial X-linked diseases that have either of two different phenotypes. First, AIF mutations can cause a severe pediatric mitochondriopathy linked to reduced expression and function of respiratory chain complexes. Second, the so-called Cowchock syndrome is caused by a mutation of AIF that increases its cytocidal potential.	NADH is important for the stabilization of the AIF-CHCHD4 complex.	Homo sapiens (Human);Homo sapiens (Human)	Apoptosis-inducing factor 1, mitochondrial;Mitochondrial intermembrane space import and assembly protein 40	AIFM1;CHCHD4	AIF, PDCD8;MIA40
8591	CTBP2-FOXP3-HDAC1 complex	Human	CHFTC complex; CtBP2-HDAC1-FOXP3 transcriptional complex	A549 cells	P56545;Q13547;Q9BZS1	1488;3065;50943	MI:0007-anti tag coimmunoprecipitation	GO:1902894;GO:0050729;GO:0002221;GO:0031334;GO:0045088;GO:1904784	negative regulation of miRNA transcription;positive regulation of inflammatory response;pattern recognition receptor signaling pathway;positive regulation of protein-containing complex assembly;regulation of innate immune response;NLRP1 inflammasome complex assembly	None	None	31754335	This complex specifically binds to the promoter and represses the expression of miR-199a-3p which is significantly downregulated in lung tissues of patients with acute lung injury. NLRP1 is a target of miR-199a-3p. Downregulation of miR-199a-3p eliminated its repression against NLRP1, thereby causing the upregulation of NLRP1. (PMID:31754335)	The CHFTC complex transcriptional complex contributes to acute lung injury by targeting NLRP1. (PMID:31754335)	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	C-terminal-binding protein 2;Histone deacetylase 1;Forkhead box protein P3	CTBP2;HDAC1;FOXP3	None;RPD3L1;IPEX
8593	NLRP1 inflammasome	Human	None	in vitro	P29466;Q9C000;Q9ULZ3	834;22861;29108	MI:0007-anti tag coimmunoprecipitation;MI:0045-experimental interaction detection	GO:0051607;GO:0045087;GO:0072558;GO:0002221;GO:0050729;GO:0032731;GO:0032496;GO:0042742;GO:0061702;GO:0140639;GO:0140447	defense response to virus;innate immune response;NLRP1 inflammasome complex;pattern recognition receptor signaling pathway;positive regulation of inflammatory response;positive regulation of interleukin-1 beta production;response to lipopolysaccharide;defense response to bacterium;inflammasome complex;positive regulation of pyroptosis;cytokine precursor processing	36.25.16.01	innate immune response (invertebrates and vertebrates)	17349957	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Caspase-1;NACHT, LRR and PYD domains-containing protein 1;Apoptosis-associated speck-like protein containing a CARD	CASP1;NLRP1;PYCARD	IL1BC, IL1BCE;CARD7 DEFCAP KIAA0926 NAC NALP1;ASC CARD5 TMS1
8594	DMXL1-ROGDI-WDR7 complex	Human	RAVE-like complex	HEK293T cells	Q9GZN7;Q9Y485;Q9Y4E6	79641;1657;23335	MI:0096-pull down	GO:0006457	protein folding	14.01	protein folding and stabilization	35271311	The DMXL1-ROGDI-WDR7 complex is proposed to act as a chaperone for v-ATPase assembly based on its yeast homolog.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein rogdi homolog;DmX-like protein 1;WD repeat-containing protein 7	ROGDI;DMXL1;WDR7	None;XL1;KIAA0541,TRAG
8595	DMXL2-ROGDI-WDR7 complex	Human	RAVE-like complex	HEK293T cells	Q8TDJ6;Q9GZN7;Q9Y4E6	23312;79641;23335	MI:0096-pull down	GO:0006457	protein folding	14.01	protein folding and stabilization	35271311	The DMXL2-ROGDI-WDR7 complex is proposed to act as a chaperone for v-ATPase assembly based on its yeast homolog.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	DmX-like protein 2;Protein rogdi homolog;WD repeat-containing protein 7	DMXL2;ROGDI;WDR7	KIAA0856;None;KIAA0541,TRAG
8596	EIF4E2-GIGYF2-ZNF598 complex	Human	m4EHP complex	HEK293 cells	O60573;Q6Y7W6;Q86UK7	9470;26058;90850	MI:0007-anti tag coimmunoprecipitation	GO:0017148;GO:0009790	negative regulation of translation;embryo development	None	None	22751931	The EIF4E2-GIGYF2-ZNF598 complex functions as a translational repressor and is essential for normal embryonic development in mice. EIF4E2 KO embryos die within a few hours of birth.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Eukaryotic translation initiation factor 4E type 2;GRB10-interacting GYF protein 2;E3 ubiquitin-protein ligase ZNF598	EIF4E2;GIGYF2;ZNF598	EIF4EL3;KIAA0642,PERQ2,TNRC15;None
8597	KPNB1-SMN1-SNUPN-ZRP1 complex	Human	KPNB1-SMN1-SNUPN-ZNF259 complex	HeLa cells	O75312;O95149;Q14974;Q16637	8882;10073;3837;None	MI:0007-anti tag coimmunoprecipitation;MI:0071-molecular sieving	GO:0005737;GO:0006404;GO:0005634	cytoplasm;RNA import into nucleus;nucleus	70.03;70.10	cytoplasm;nucleus	12095920	Findings that SMN directly interacts with importin beta (KPNB1) and that snurportin1 (SNUPN), SMN, ZPR1, importin beta and TMG-capped snRNPs form a complex indicates that SMN may be imported into the nucleus along with the snRNPs.	None	In gel filtration assays, KPNB1, SMN1, SNUPN and ZRP1 co-migrate in the 400-500 kDa region.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Zinc finger protein ZPR1;Snurportin-1;Importin subunit beta-1;Survival motor neuron protein	ZPR1;SNUPN;KPNB1;SMN1	ZNF259;RNUT1 SPN1;NTF97;SMN SMNT
8600	MIA complex (CHCHD4, GFER), mitochondrial	Human	ALR-MIA40 complex	S. cerevisiae strains expressing human proteins via plasmid shuffling	P55789;Q8N4Q1	2671;131474	MI:0047-far western blotting	GO:0005758;GO:0045041;GO:0006457;GO:0005739;GO:0006839;GO:0006626	mitochondrial intermembrane space;protein import into mitochondrial intermembrane space;protein folding;mitochondrion;mitochondrial transport;protein targeting to mitochondrion	70.16.03;14.01;70.16;20.09.04	mitochondrial intermembrane space;protein folding and stabilization;mitochondrion;mitochondrial transport	23186364	The conserved MIA pathway is responsible for the import and oxidative folding of proteins destined for the intermembrane space of mitochondria. The yeast model for MIA consists of two critical components, the disulfide bond carrier Mia40 and sulfhydryl oxidase Erv1/ALR. Human MIA40 (hMIA40) and ALR (hALR) substituted for their yeast counterparts in the essential function for the oxidative biogenesis of mitochondrial intermembrane space proteins. hMIA40 and hALR were found to interact.	None	None	Homo sapiens (Human);Homo sapiens (Human)	FAD-linked sulfhydryl oxidase ALR;Mitochondrial intermembrane space import and assembly protein 40	GFER;CHCHD4	ALR HERV1 HPO;MIA40
8601	DYRK1B-RANBP9 complex	Human	MIRK-RANBPM complex	HEK293T cells	Q96S59;Q9Y463	10048;9149	MI:0007-anti tag coimmunoprecipitation;MI:0071-molecular sieving	GO:0006355;GO:0030334	regulation of DNA-templated transcription;regulation of cell migration	11.02.03.04	transcriptional control	14500717	The DYRK1B-RANBP9 complex provides a novel control point for cell motility and invasion. RANBP9 inhibits the function of DYRK1B as a transcriptional coactivator.	None	In gelfiltration experiments DYRK1B and RANBP9 comigrate in a 660-670 kDa complex.	Homo sapiens (Human);Homo sapiens (Human)	Ran-binding protein 9;Dual specificity tyrosine-phosphorylation-regulated kinase 1B	RANBP9;DYRK1B	RANBPM;MIRK
8602	ENTR1-GIT1-PTPN13 complex	Human	GIT1-PTPN13-SDCCAG3 complex	colon cancer cells	Q12923;Q96C92;Q9Y2X7	5783;10807;28964	MI:0096-pull down	GO:0000910	cytokinesis	10.03.03	cytokinesis (cell division) /septum formation and hydrolysis	23108400	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Tyrosine-protein phosphatase non-receptor type 13;Endosome-associated-trafficking regulator 1;ARF GTPase-activating protein GIT1	PTPN13;ENTR1;GIT1	PNP1 PTP1E PTPL1;SDCCAG3;None
8605	IFN-lambda receptor-IFN-lambda1 complex	Human	IFN-lambdaR1-IL-10R receptor-IFN-lambda1 complex; IFNLR1-IL10RB-IFNL1 complex	COS-1 cells, transfected with human genes	Q08334;Q8IU54;Q8IU57	3588;282618;163702	MI:0030-cross-linking study	GO:0038196;GO:0046425;GO:0051607;GO:0019221;GO:0045087	type III interferon signaling pathway;regulation of receptor signaling pathway via JAK-STAT;defense response to virus;cytokine-mediated signaling pathway;innate immune response	36.25.16.01	innate immune response (invertebrates and vertebrates)	12483210	This receptor is utilized by all three IFN-? proteins, IFN-lambda1, IFN-lambda2 and IFN-lambda3, for signaling. The subunit CRF2-4 (IL10RB) is a shared receptor component within the IL-10 and IL-22 receptor complexes.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Interleukin-10 receptor subunit beta;Interferon lambda-1;Interferon lambda receptor 1	IL10RB;IFNL1;IFNLR1	CRFB4 D21S58 D21S66;IL29,ZCYTO21;IL28RA LICR2
8607	CXCR4-GDF5-HSPA8-HSP90AA1 complex	Human	None	ECV-304 cells	P07900;P11142;P43026;P61073	3320;3312;8200;7852	MI:0004-affinity chromatography technology;MI:0055-fluorescent resonance energy transfer	GO:0007165;GO:0001530	signal transduction;lipopolysaccharide binding	30	CELLULAR COMMUNICATION/SIGNAL TRANSDUCTION MECHANISM	11276205	The authors show evidence that the CXCR4-GDF5-HSPA8-HSP90AA1 complex is a main mediator of activation by bacterial lipopolysaccharide.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Heat shock protein HSP 90-alpha;Heat shock cognate 71 kDa protein;Growth/differentiation factor 5;C-X-C chemokine receptor type 4	HSP90AA1;HSPA8;GDF5;CXCR4	HSP90A HSPC1 HSPCA;HSC70 HSP73 HSPA10;BMP14 CDMP1;None
8608	CD274-RAB11A-TRAPPC4 complex	Human	None	colon cancer cells	P62491;Q9NZQ7;Q9Y296	8766;29126;51399	MI:0019-coimmunoprecipitation;MI:0051-fluorescence technology	GO:0055037;GO:0016192;GO:0099022;GO:0006955	recycling endosome;vesicle-mediated transport;vesicle tethering;immune response	20.09.07;36.25.16	vesicular transport (Golgi network, etc.);immune response	34518538	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Ras-related protein Rab-11A;Programmed cell death 1 ligand 1;Trafficking protein particle complex subunit 4	RAB11A;CD274;TRAPPC4	RAB11;B7H1 PDCD1L1 PDCD1LG1 PDL1;SBDN
8611	SUG1-NLRC4-CASP8 complex	Human	SUG1-IPAF-CASP8 complex; PSMC5-NLRC4-CASP8 complex	A549 cells	P62195;Q14790;Q9NPP4	5705;841;58484	MI:0006-anti bait coimmunoprecipitation;MI:0663-confocal microscopy	GO:0016567;GO:0043065	protein ubiquitination;positive regulation of apoptotic process	14.07.05	modification by ubiquitination, deubiquitination	20085538	SUG1 interacts with IPAF to enable IPAF ubiquitination. Ubiquitinated IPAF recruits caspase 8, forming a multimolecular complex responsible for caspase 8-dependent cell death.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	26S proteasome regulatory subunit 8;Caspase-8;NLR family CARD domain-containing protein 4	PSMC5;CASP8;NLRC4	SUG1;MCH5;CARD12 CLAN CLAN1 IPAF
8612	NLRP3 inflammasome	Human	NLRP3-PYCARD-CASP1 complex; NLRP3-ASC-CASP1 complex	in vitro	P29466;Q96P20;Q9ULZ3	834;114548;29108	MI:0040-electron microscopy;MI:0045-experimental interaction detection	GO:0042742;GO:0050832;GO:0051607;GO:0045087;GO:0002221;GO:0072559;GO:0050729;GO:0032731;GO:0000302;GO:0043331;GO:0061702;GO:0032741;GO:0140447;GO:0019048	defense response to bacterium;defense response to fungus;defense response to virus;innate immune response;pattern recognition receptor signaling pathway;NLRP3 inflammasome complex;positive regulation of inflammatory response;positive regulation of interleukin-1 beta production;response to reactive oxygen species;response to dsRNA;inflammasome complex;positive regulation of interleukin-18 production;cytokine precursor processing;modulation by virus of host process	36.25.16.01;32.01.01	innate immune response (invertebrates and vertebrates);oxidative stress response	24630722	SARS-CoV-2 N protein directly interacts with NLRP3 and facilitates the oligomerization of ASC. The N-NLRP3-ASC complex promotes the assembly and activation of the NLRP3 inflammasome and induces hyperinflammation (PMID:34341353). The Zika virus NS5 protein (PMID:29317641) and M protein of Dengue virus (PMID:31413130) are known to interact with NLRP3 to activate the NLRP3 inflammasome thus exacerbating disease progression.	SARS-CoV-2 N protein aggravates lung injury through facilitating the NLRP3 inflammasome activation (PMID:34341353).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Caspase-1;NACHT, LRR and PYD domains-containing protein 3;Apoptosis-associated speck-like protein containing a CARD	CASP1;NLRP3;PYCARD	IL1BC, IL1BCE;C1orf7 CIAS1 NALP3 PYPAF1;ASC CARD5 TMS1
8613	TRAPP III complex	Human	None	HEK293T cells	A5PLN9;O43617;O75865;P0DI81;Q7Z392;Q86SZ2;Q8IUR0;Q8WVT3;Q9UL33;Q9Y296;Q9Y2L5;Q9Y5R8	80006;27095;79090;6399;60684;122553;126003;51112;51693;51399;22878;58485	MI:0019-coimmunoprecipitation;MI:0069-mass spectrometry studies of complexes	GO:0034976;GO:0006915;GO:0006914	response to endoplasmic reticulum stress;apoptotic process;autophagy	40.10.02	apoptosis (type I programmed cell death)	28536105	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Trafficking protein particle complex subunit 13;Trafficking protein particle complex subunit 3;Trafficking protein particle complex subunit 6A;Trafficking protein particle complex subunit 2;Trafficking protein particle complex subunit 11;Trafficking protein particle complex subunit 6B;Trafficking protein particle complex subunit 5;Trafficking protein particle complex subunit 12;Trafficking protein particle complex subunit 2-like protein;Trafficking protein particle complex subunit 4;Trafficking protein particle complex subunit 8;Trafficking protein particle complex subunit 1	TRAPPC13;TRAPPC3;TRAPPC6A;TRAPPC2;TRAPPC11;TRAPPC6B;TRAPPC5;TRAPPC12;TRAPPC2L;TRAPPC4;TRAPPC8;TRAPPC1	C5orf44;BET3;None;SEDL;C4orf41;None;None;TRAMM TTC15;None;SBDN;KIAA1012;BET5,MUM2
8614	CD36-TLR2-TLR6 complex	Human	TLR2-TLR6-CD36 complex; Toll-like receptor 2-Toll-like receptor 6-CD36 complex	monocytes , HEK293 cells, stimulated with lipoteichoic acid	O60603;P16671;Q9Y2C9	7097;948;10333	MI:0051-fluorescence technology;MI:0663-confocal microscopy	GO:0002221;GO:0045087;GO:0002224;GO:0038124;GO:0070391;GO:0070891;GO:0071724;GO:0042498;GO:0042742;GO:0045893;GO:0051092	pattern recognition receptor signaling pathway;innate immune response;toll-like receptor signaling pathway;toll-like receptor TLR6:TLR2 signaling pathway;response to lipoteichoic acid;lipoteichoic acid binding;response to diacyl bacterial lipopeptide;diacyl lipopeptide binding;defense response to bacterium;positive regulation of DNA-templated transcription;positive regulation of NF-kappaB transcription factor activity	36.25.16.01;11.02.03.04.01	innate immune response (invertebrates and vertebrates);transcription activation	16880211	After stimulation with lipoteichoic acid, pre-existing TLR2-TLR6 heterodimers along with CD36 are targeted to the Golgi apparatus.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Toll-like receptor 2;Platelet glycoprotein 4;Toll-like receptor 6	TLR2;CD36;TLR6	TIL4;GP3B GP4;None
8615	TLR2-TLR6 complex	Human	Toll-like receptor 2-Toll-like receptor 6 complex	monocytes, HEK293 cells	O60603;Q9Y2C9	7097;10333	MI:0051-fluorescence technology;MI:0663-confocal microscopy	GO:0042742;GO:0045087;GO:0002221;GO:0035355;GO:0002224;GO:0038124;GO:0045893;GO:0051092;GO:0032494;GO:0042834	defense response to bacterium;innate immune response;pattern recognition receptor signaling pathway;Toll-like receptor 2-Toll-like receptor 6 protein complex;toll-like receptor signaling pathway;toll-like receptor TLR6:TLR2 signaling pathway;positive regulation of DNA-templated transcription;positive regulation of NF-kappaB transcription factor activity;response to peptidoglycan;peptidoglycan binding	36.25.16.01;11.02.03.04.01	innate immune response (invertebrates and vertebrates);transcription activation	16880211	The TLR2-TLR6 heterodimer pre-exists in the cell. Heterodimerization is not induced by the ligand. Upon stimulation by the specific ligand, these heterodimers are recruited within lipid rafts and interact with CD36 (Corum-ID:8614).	None	None	Homo sapiens (Human);Homo sapiens (Human)	Toll-like receptor 2;Toll-like receptor 6	TLR2;TLR6	TIL4;None
8616	SRI complex	Human	Sensitization-to-ricin complex	HeLa cells	Q9BZH6;Q9HAS0	55717;64149	MI:0019-coimmunoprecipitation;MI:0069-mass spectrometry studies of complexes	GO:0009407;GO:0006914	toxin catabolic process;autophagy	None	None	23394947	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	WD repeat-containing protein 11;Protein Njmu-R1	WDR11;C17orf75	BRWD2 KIAA1351 WDR15;None
8617	RP105-MD1 complex	Human	CD180-LY86 complex	in vitro	O95711;Q99467	9450;4064	MI:0114-x-ray crystallography	GO:0034121;GO:0034143;GO:0001530;GO:0032496;GO:0045087;GO:0002221;GO:0034135;GO:0042742	regulation of toll-like receptor signaling pathway;regulation of toll-like receptor 4 signaling pathway;lipopolysaccharide binding;response to lipopolysaccharide;innate immune response;pattern recognition receptor signaling pathway;regulation of toll-like receptor 2 signaling pathway;defense response to bacterium	36.25.16.01	innate immune response (invertebrates and vertebrates)	21959264	The RP105-MD1 complex modulates the TLR4-MD2 complex-mediated innate immune response against bacterial lipopolysaccharide. (PMID:21857663)	None	None	Homo sapiens (Human);Homo sapiens (Human)	Lymphocyte antigen 86;CD180 antigen	LY86;CD180	MD1;LY64 RP105
8619	TICAM1-TLR3 complex	Human	TLR3-TICAM1 complex: Toll-like receptor 3-TICAM1 complex	HEK293 cells	O15455;Q8IUC6	7098;148022	MI:0007-anti tag coimmunoprecipitation	GO:0045087;GO:0002221;GO:0002224;GO:0034138;GO:0002756;GO:0043331;GO:0032481;GO:0032728;GO:0006952	innate immune response;pattern recognition receptor signaling pathway;toll-like receptor signaling pathway;toll-like receptor 3 signaling pathway;MyD88-independent toll-like receptor signaling pathway;response to dsRNA;positive regulation of type I interferon production;positive regulation of interferon-beta production;defense response	36.25.16.01	innate immune response (invertebrates and vertebrates)	12539043	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Toll-like receptor 3;TIR domain-containing adapter molecule 1	TLR3;TICAM1	None;PRVTIRB TRIF
8620	IL1R1-IL1RAP-IRAK2 complex	Human	IL-1 receptor type 1-IRAK2 complex; Interleukin-1 receptor type 1-IRAK2 complex; IL1R1-IL1RAP-IRAK2 complex	HEK293T cells	O43187;P14778;Q9NPH3	3656;3554;3556	MI:0007-anti tag coimmunoprecipitation	GO:0051092;GO:0006955;GO:0070498;GO:0050727;GO:0019221;GO:0006952	positive regulation of NF-kappaB transcription factor activity;immune response;interleukin-1-mediated signaling pathway;regulation of inflammatory response;cytokine-mediated signaling pathway;defense response	36.25.16	immune response	23264670	IRAK2 is a component of the IL-1 signaling complex. Although MyD88 interacts with IRAK2 and IL1RAP, the authors were not able to assemble a complex between MyD88, IRAK2 and the IL-1 receptor, indicating that MyD88 is only transiently associated with the complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Interleukin-1 receptor-associated kinase-like 2;Interleukin-1 receptor type 1;Interleukin-1 receptor accessory protein	IRAK2;IL1R1;IL1RAP	None;IL1R IL1RA IL1RT1;C3orf13 IL1R3
8621	IL1R1-IL1RAP-IRAK1-MYD88 complex	Human	IL-1 receptor type 1-IRAK1-MYD88 complex; Interleukin-1 receptor type 1-IRAK1-MYD88 complex	HEK293 cells, IL-1beta stimulated	P14778;P51617;Q99836;Q9NPH3	3554;3654;4615;3556	MI:0007-anti tag coimmunoprecipitation	GO:0006955;GO:0019221;GO:0006952;GO:0045087;GO:0070498;GO:0051092;GO:0050727;GO:0070555	immune response;cytokine-mediated signaling pathway;defense response;innate immune response;interleukin-1-mediated signaling pathway;positive regulation of NF-kappaB transcription factor activity;regulation of inflammatory response;response to interleukin-1	36.25.16;36.25.16.01	immune response;innate immune response (invertebrates and vertebrates)	23264669	MyD88 is recruited to the IL-1 receptor following IL-1 stimulation and functions as an adaptor to recruit IRAK to the receptor complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Interleukin-1 receptor type 1;Interleukin-1 receptor-associated kinase 1;Myeloid differentiation primary response protein MyD88;Interleukin-1 receptor accessory protein	IL1R1;IRAK1;MYD88;IL1RAP	IL1R IL1RA IL1RT1;IRAK;None;C3orf13 IL1R3
8622	Apoptosis- and splicing-associated protein complex (SAP18, RNPS1, Acinus-L)	Human	ASAP-L complex	HeLa cells	O00422;Q15287;Q9UKV3-1	10284;10921;22985	MI:0004-affinity chromatography technology;MI:0006-anti bait coimmunoprecipitation	GO:0006915;GO:0006397;GO:0000398;GO:0005634	apoptotic process;mRNA processing;mRNA splicing, via spliceosome;nucleus	40.10.02;11.04.03;70.10	apoptosis (type I programmed cell death);mRNA processing (splicing, 5'-, 3'-end processing);nucleus	12665594	In vitro splicing assays suggest that the ASAP complexes function to repress splicing in vitro and that the ability of RNPS1 (and possibly Acinus-L) to activate splicing is overcome both when it is a component of ASAP and in the presence of the intact complex. In vitro assays using an apoptotic extract strongly indicate that ASAP complexes disassemble during apoptosis.	None	The ASAP complexes exist in at least two isoforms, termed ASAP-L and ASAP-S, which are characterized by the presence of different splice variants of Acinus (ACIN1), ACIN1-L and ACIN1-S, respectively.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone deacetylase complex subunit SAP18;RNA-binding protein with serine-rich domain 1;Isoform 1 of Apoptotic chromatin condensation inducer in the nucleus	SAP18;RNPS1;ACIN1	None;LDC2;ACINUS KIAA0670
8623	Rixosome	Human	None	HEK 293FT cells	Q5SY16;Q8IZL8;Q9BV38;Q9H4L4;Q9NU22;Q9NXF1;Q9Y4W2	79707;27043;57418;26168;23195;54881;81887	MI:0019-coimmunoprecipitation	GO:0010629;GO:0005634;GO:0006364	negative regulation of gene expression;nucleus;rRNA processing	70.10;11.04.01	nucleus;rRNA processing	35355014	The rixosome contributes to silencing of many Polycomb targets in human cells. The rixosome associates with human polycomb repressive complexes and is enriched at promoters of Polycomb target genes.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Polynucleotide 5'-hydroxyl-kinase NOL9;Proline-, glutamic acid- and leucine-rich protein 1;WD repeat-containing protein 18;Sentrin-specific protease 3;Midasin;Testis-expressed protein 10;Ribosomal biogenesis protein LAS1L	NOL9;PELP1;WDR18;SENP3;MDN1;TEX10;LAS1L	None;HMX3 MNAR;None;SSP3, SUSP3;KIAA0301;None;None
8624	TIRAP-TRAF6 complex	Human	MAL-TRAF6 complex	HEK293T cells	P58753;Q9Y4K3	114609;7189	MI:0007-anti tag coimmunoprecipitation	GO:0051092;GO:0032496;GO:0006954;GO:0002756;GO:0002221;GO:0045087;GO:0034142;GO:0034134	positive regulation of NF-kappaB transcription factor activity;response to lipopolysaccharide;inflammatory response;MyD88-independent toll-like receptor signaling pathway;pattern recognition receptor signaling pathway;innate immune response;toll-like receptor 4 signaling pathway;toll-like receptor 2 signaling pathway	36.25.16.07;36.25.16.01	inflammatory response;innate immune response (invertebrates and vertebrates)	15247281	TIRAP (MAL) interacts with TRAF6 in response to TLR2 and TLR4 stimulation. By mediating Ser phosphorylation of the p65 subunit of NF-kappaB the complex is responsible for transactivation of NF-kappaB. (PMID:19592497)	None	None	Homo sapiens (Human);Homo sapiens (Human)	Toll/interleukin-1 receptor domain-containing adapter protein;TNF receptor-associated factor 6	TIRAP;TRAF6	MAL;RNF85
8625	RAB11a-RAB11FIP2-TICAM1-TICAM2 complex	Human	TICAM1-TICAM2-RAB11FIP2-RAB11a complex; TRIF-TRAM-FIP2-RAB11A complex	THP-1 cells, stimulated by E.coli	P62491;Q7L804;Q86XR7;Q8IUC6	8766;22841;None;148022	MI:0007-anti tag coimmunoprecipitation	GO:0042742;GO:0002221;GO:0045087;GO:0032481;GO:0032728;GO:0002756;GO:0035669;GO:0050766;GO:0034142;GO:0002224	defense response to bacterium;pattern recognition receptor signaling pathway;innate immune response;positive regulation of type I interferon production;positive regulation of interferon-beta production;MyD88-independent toll-like receptor signaling pathway;TRAM-dependent toll-like receptor 4 signaling pathway;positive regulation of phagocytosis;toll-like receptor 4 signaling pathway;toll-like receptor signaling pathway	36.25.16.01	innate immune response (invertebrates and vertebrates)	30883606	FIP2 exists in a preformed complex with TRAM and TRIF (TICAM2, TICAM1) that is rapidly recruited to the E. coli binding site and enhanced by TLR4 activation. Interaction of FIP2 with TRAM controls both phagocytosis and TLR4-mediated TRAM-TRIF signaling from E. coli phagosomes. FIP2 binding to TRAM occurs via FIP2 and Rab11 positively regulates TRAM-FIP2 complex formation.(PMID:30883606)	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Ras-related protein Rab-11A;Rab11 family-interacting protein 2;TIR domain-containing adapter molecule 2;TIR domain-containing adapter molecule 1	RAB11A;RAB11FIP2;TICAM2;TICAM1	RAB11;KIAA0941;TIRAP3 TIRP TRAM;PRVTIRB TRIF
8626	RAB11A-RAB11FIP1-SLAMF1 complex	Human	SLAMF1-RAB11A-RAB11FIP1 complex; SLAMF1-RAB11a-FIP1 complex	HEK293 cells	P62491;Q13291;Q6WKZ4	8766;6504;80223	MI:0007-anti tag coimmunoprecipitation	GO:0002221;GO:0034143;GO:0045087;GO:0032481;GO:0032728;GO:0042742;GO:2001135;GO:0060627;GO:0034127;GO:0016192	pattern recognition receptor signaling pathway;regulation of toll-like receptor 4 signaling pathway;innate immune response;positive regulation of type I interferon production;positive regulation of interferon-beta production;defense response to bacterium;regulation of endocytic recycling;regulation of vesicle-mediated transport;regulation of MyD88-independent toll-like receptor signaling pathway;vesicle-mediated transport	36.25.16.01;20.09.07	innate immune response (invertebrates and vertebrates);vesicular transport (Golgi network, etc.)	29440514	SLAMF1 functions as regulator of TLR4-mediated signaling from phagosomes. By interacting with the TRAM adapter RAB11a and class I FIPs (FIP1, FIP2, FIP5) TRAM is recruited to the TLR4-TRAM-TRIF complex (CORUM-ID:1714)	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Ras-related protein Rab-11A;Signaling lymphocytic activation molecule;Rab11 family-interacting protein 1	RAB11A;SLAMF1;RAB11FIP1	RAB11;SLAM;RCP
8627	CD44-ERBB2-GRB2-VAV2 complex	Human	CD44-p185HER2-GRB2-VAV2 complex	SK-OV-3 human ovarian carcinoma cell line	P04626;P16070;P52735;P62993	2064;960;7410;2885	MI:0019-coimmunoprecipitation	GO:0007265;GO:0016477;GO:0016049	Ras protein signal transduction;cell migration;cell growth	34.05.01;40.01	cell migration;cell growth / morphogenesis	11606575	CD44-VAV2 interaction with the GRB2- ERBB2 (p185HER2) complex plays an important role in promoting hyaluronan-dependent Rac1 activation and Ras signaling leading to the concomitant stimulation of human ovarian tumor cell migration and growth.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Receptor tyrosine-protein kinase erbB-2;CD44 antigen;Guanine nucleotide exchange factor VAV2;Growth factor receptor-bound protein 2	ERBB2;CD44;VAV2;GRB2	HER2 MLN19 NEU NGL;LHR MDU2 MDU3 MIC4;None;ASH
8628	RAB11A-RAB11FIP2-SLAMF1 complex	Human	SLAMF1-RAB11A-RAB11FIP2 complex; SLAMF1-RAB11a-FIP2 complex	HEK293 cells	P62491;Q13291;Q7L804	8766;6504;22841	MI:0007-anti tag coimmunoprecipitation	GO:0042742;GO:0002221;GO:0045087;GO:0032728;GO:0032481;GO:2001135;GO:0034143;GO:0060627;GO:0034127;GO:0016192	defense response to bacterium;pattern recognition receptor signaling pathway;innate immune response;positive regulation of interferon-beta production;positive regulation of type I interferon production;regulation of endocytic recycling;regulation of toll-like receptor 4 signaling pathway;regulation of vesicle-mediated transport;regulation of MyD88-independent toll-like receptor signaling pathway;vesicle-mediated transport	36.25.16.01;20.09.07	innate immune response (invertebrates and vertebrates);vesicular transport (Golgi network, etc.)	29440514	SLAMF1 functions as regulator of TLR4-mediated signaling from phagosomes. By interacting with the TRAM adapter RAB11a and class I FIPs (FIP1, FIP2, FIP5) TRAM is recruited to the TLR4-TRAM-TRIF complex (CORUM-ID:1714)	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Ras-related protein Rab-11A;Signaling lymphocytic activation molecule;Rab11 family-interacting protein 2	RAB11A;SLAMF1;RAB11FIP2	RAB11;SLAM;KIAA0941
8629	RAB11A-RAB11FIP5-SLAMF1 complex	Human	SLAMF1-RAB11A-RAB11FIP5; SLAMF1-RAB11a-FIP5 complex	HEK293 cells	P62491;Q13291;Q9BXF6	8766;6504;26056	MI:0007-anti tag coimmunoprecipitation	GO:0002221;GO:0045087;GO:0042742;GO:0032728;GO:0032481;GO:0034143;GO:0060627;GO:2001135;GO:0034127;GO:0016192	pattern recognition receptor signaling pathway;innate immune response;defense response to bacterium;positive regulation of interferon-beta production;positive regulation of type I interferon production;regulation of toll-like receptor 4 signaling pathway;regulation of vesicle-mediated transport;regulation of endocytic recycling;regulation of MyD88-independent toll-like receptor signaling pathway;vesicle-mediated transport	36.25.16.01;20.09.07	innate immune response (invertebrates and vertebrates);vesicular transport (Golgi network, etc.)	29440514	SLAMF1 functions as regulator of TLR4-mediated signaling from phagosomes. By interacting with the TRAM adapter RAB11a and class I FIPs (FIP1, FIP2, FIP5) TRAM is recruited to the TLR4-TRAM-TRIF complex (CORUM-ID:1714)	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Ras-related protein Rab-11A;Signaling lymphocytic activation molecule;Rab11 family-interacting protein 5	RAB11A;SLAMF1;RAB11FIP5	RAB11;SLAM;GAF1 KIAA0857 RIP11
8630	VPS34-VPS15-BECLIN1-SLAMF1 complex	Human	PIK3C3-PIK3R4-BECN1-SLAMF1 complex	HEK293 cells	Q13291;Q14457;Q8NEB9;Q99570	6504;8678;5289;30849	MI:0019-coimmunoprecipitation	GO:0045087;GO:0002221;GO:0042742;GO:0090382;GO:0014068;GO:0032930;GO:0050766	innate immune response;pattern recognition receptor signaling pathway;defense response to bacterium;phagosome maturation;positive regulation of phosphatidylinositol 3-kinase signaling;positive regulation of superoxide anion generation;positive regulation of phagocytosis	36.25.16.01	innate immune response (invertebrates and vertebrates)	20818396	SLAMF1 is a microbial sensor that recognizes bacterial surface proteins embedded in the outer membrane of most Gram-negative bacteria. SLAMF1 recruits the VPS34-VPS15-BECLIN1 complex to the early phagosome to induce NOX2 activity by accumulation of PtdIns(3)P in the lipid bilayer of the phagosome. Thus, SLAMF1 regulates two main bactericidal processes: phagosome maturation and the production of free radical species by the NOX2 complex. (PMID:20818396, 22493499)	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Signaling lymphocytic activation molecule;Beclin-1;Phosphatidylinositol 3-kinase catalytic subunit type 3;Phosphoinositide 3-kinase regulatory subunit 4	SLAMF1;BECN1;PIK3C3;PIK3R4	SLAM;GT197;VPS34;VPS15
8632	VPS34-VPS15-BECLIN1-UVRAG-SLAMF1 complex	Human	PIK3C3-PIK3R4-BECN1-UVRAG-SLAMF1 complex	CLL cells; transfectant HEK293 cells	Q13291;Q14457;Q8NEB9;Q99570;Q9P2Y5	6504;8678;5289;30849;7405	MI:0006-anti bait coimmunoprecipitation	GO:0090382;GO:0042742;GO:0002221;GO:0045087;GO:0014068;GO:0032930;GO:0050766	phagosome maturation;defense response to bacterium;pattern recognition receptor signaling pathway;innate immune response;positive regulation of phosphatidylinositol 3-kinase signaling;positive regulation of superoxide anion generation;positive regulation of phagocytosis	36.25.16.01	innate immune response (invertebrates and vertebrates)	22493499	SLAMF1 regulates membrane fusion and NADPH oxidase 2 activity by recruiting the VPS24/15-BECLIN1-UVRAG to the early phagosomes. This complex is formed even without induction of phagocytosis, instead, Slamf1 uses this complex as a universal signaling pathway to employ its function in more than macrophages.	None	The authors did not show immunoprecipitation of the subunit VPS15, but it is mentioned in the publication, that VPS15 is a component of the complex.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Signaling lymphocytic activation molecule;Beclin-1;Phosphatidylinositol 3-kinase catalytic subunit type 3;Phosphoinositide 3-kinase regulatory subunit 4;UV radiation resistance-associated gene protein	SLAMF1;BECN1;PIK3C3;PIK3R4;UVRAG	SLAM;GT197;VPS34;VPS15;None
8634	mTRAPP II complex	Human	None	HeLa cells	O43617;O75865;P0DI81;P48553;Q86SZ2;Q8IUR0;Q96Q05;Q9UL33;Q9Y296;Q9Y5R8	27095;79090;6399;7109;122553;126003;83696;51693;51399;58485	MI:0019-coimmunoprecipitation	GO:0099022;GO:0060271	vesicle tethering;cilium assembly	None	None	23394947	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Trafficking protein particle complex subunit 3;Trafficking protein particle complex subunit 6A;Trafficking protein particle complex subunit 2;Trafficking protein particle complex subunit 10;Trafficking protein particle complex subunit 6B;Trafficking protein particle complex subunit 5;Trafficking protein particle complex subunit 9;Trafficking protein particle complex subunit 2-like protein;Trafficking protein particle complex subunit 4;Trafficking protein particle complex subunit 1	TRAPPC3;TRAPPC6A;TRAPPC2;TRAPPC10;TRAPPC6B;TRAPPC5;TRAPPC9;TRAPPC2L;TRAPPC4;TRAPPC1	BET3;None;SEDL;EHOC1,TMEM1;None;None;KIAA1882 NIBP;None;SBDN;BET5,MUM2
8635	mTRAPP III complex	Human	None	HeLa cells	A5PLN9;O43617;O75865;P0DI81;Q7Z392;Q86SZ2;Q8IUR0;Q8WVT3;Q9UL33;Q9Y296;Q9Y2L5;Q9Y5R8	80006;27095;79090;6399;60684;122553;126003;51112;51693;51399;22878;58485	MI:0019-coimmunoprecipitation	GO:0099022	vesicle tethering	None	None	23394947	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Trafficking protein particle complex subunit 13;Trafficking protein particle complex subunit 3;Trafficking protein particle complex subunit 6A;Trafficking protein particle complex subunit 2;Trafficking protein particle complex subunit 11;Trafficking protein particle complex subunit 6B;Trafficking protein particle complex subunit 5;Trafficking protein particle complex subunit 12;Trafficking protein particle complex subunit 2-like protein;Trafficking protein particle complex subunit 4;Trafficking protein particle complex subunit 8;Trafficking protein particle complex subunit 1	TRAPPC13;TRAPPC3;TRAPPC6A;TRAPPC2;TRAPPC11;TRAPPC6B;TRAPPC5;TRAPPC12;TRAPPC2L;TRAPPC4;TRAPPC8;TRAPPC1	C5orf44;BET3;None;SEDL;C4orf41;None;None;TRAMM TTC15;None;SBDN;KIAA1012;BET5,MUM2
8639	PRLR heterodimer complex, long/short form (LF/S1b)	Human	None	HEK293 cells	P16471-1;P16471-6	5618;5618	MI:0012-bioluminescence resonance energy transfer;MI:0019-coimmunoprecipitation;MI:0047-far western blotting	GO:0004925;GO:0005148;GO:0046983	prolactin receptor activity;prolactin receptor binding;protein dimerization activity	None	None	16556730	The process of receptor dimerization can be either constitutive or ligand dependent. The receptor dimer appears in variant (alternatively spliced) forms: as heterodimer long form (LF, 622 aa) - short form (SF) S1a (376 aa) or S1b (288 aa) and homodimers LF - LF, SF - SF. The LF and both SFs of the hPRLR formed homodimers under nonreducing conditions, independently of PRL, but formed only monomers under reducing conditions. Although SF homodimers and their heterodimers with LF mediate JAK2 activation, the SF heterodimer partner lacks cytoplasmic sequences essential for activation of the JAK2/signal transducer and activator of transcription 5 pathway. This prevents the heterodimeric LF from mediating activation of PRL-induced genes.	None	PRLR (long form, LF, 622 aa) = splice variant/isoform; PRLR (short form 1b, S1b, 288 aa) is a splice variant/isoform of PRLR.	Homo sapiens (Human);Homo sapiens (Human)	Isoform 1 of Prolactin receptor;Isoform 6 of Prolactin receptor	PRLR;PRLR	None;None
8640	PRLR homodimer complex, short form (S1a)	Human	None	HEK293 cells	P16471-4	5618	MI:0012-bioluminescence resonance energy transfer;MI:0019-coimmunoprecipitation;MI:0047-far western blotting	GO:0009986;GO:0004925;GO:0042803;GO:0010533	cell surface;prolactin receptor activity;protein homodimerization activity;regulation of activation of Janus kinase activity	None	None	16556730	The process of receptor dimerization can be either constitutive or ligand dependent. The receptor dimer appears in variant (alternatively spliced) forms: as heterodimer long form (LF, 622 aa) - short form (SF) S1a (376 aa) or S1b (288 aa) and homodimers LF - LF, SF - SF. The LF and both SFs of the hPRLR formed homodimers under nonreducing conditions, independently of PRL, but formed only monomers under reducing conditions. Although SF homodimers and their heterodimers with LF mediate JAK2 activation, the SF heterodimer partner lacks cytoplasmic sequences essential for activation of the JAK2/signal transducer and activator of transcription 5 pathway. This prevents the heterodimeric LF from mediating activation of PRL-induced genes.	None	PRLR (short form 1a, S1a, 376 aa) is a splice variant/isoform of PRLR.	Homo sapiens (Human)	Isoform 4 of Prolactin receptor	PRLR	None
8641	PRLR homodimer complex, short form (S1b)	Human	None	HEK293 cells	P16471-6	5618	MI:0012-bioluminescence resonance energy transfer;MI:0019-coimmunoprecipitation;MI:0047-far western blotting	GO:0009986;GO:0004925;GO:0042803;GO:0010533	cell surface;prolactin receptor activity;protein homodimerization activity;regulation of activation of Janus kinase activity	None	None	16556730	The process of receptor dimerization can be either constitutive or ligand dependent. The receptor dimer appears in variant (alternatively spliced) forms: as heterodimer long form (LF, 622 aa) - short form (SF) S1a (376 aa) or S1b (288 aa) and homodimers LF - LF, SF - SF. The LF and both SFs of the hPRLR formed homodimers under nonreducing conditions, independently of PRL, but formed only monomers under reducing conditions. Although SF homodimers and their heterodimers with LF mediate JAK2 activation, the SF heterodimer partner lacks cytoplasmic sequences essential for activation of the JAK2/signal transducer and activator of transcription 5 pathway. This prevents the heterodimeric LF from mediating activation of PRL-induced genes.	None	PRLR (short form 1b, S1b, 288 aa) is a splice variant/isoform of PRLR.	Homo sapiens (Human)	Isoform 6 of Prolactin receptor	PRLR	None
8642	CDC37-HSP90AA1-MAPK1-MAPK3-MAPK11 complex	Human	HSP90-CDC37-ERK1-ERK2-p38 complex	sperm	P07900;P27361;P28482;Q15759;Q16543	3320;5595;5594;5600;11140	MI:0019-coimmunoprecipitation	GO:0004672;GO:0048240	protein kinase activity;sperm capacitation	None	None	33663544	Hsp90 and its co-chaperone Cdc37 form a protein complex with Erk1/2 and p38 to regulate their kinase activity. These results suggest that Hsp90 regulates human sperm capacitation via the Erk1/2 and p38 MAPK signaling pathways (PMID:33663544).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Heat shock protein HSP 90-alpha;Mitogen-activated protein kinase 3;Mitogen-activated protein kinase 1;Mitogen-activated protein kinase 11;Hsp90 co-chaperone Cdc37	HSP90AA1;MAPK3;MAPK1;MAPK11;CDC37	HSP90A HSPC1 HSPCA;ERK1 PRKM3;ERK2 PRKM1 PRKM2;PRKM11 SAPK2 SAPK2B;CDC37A
8643	ABCB11-CHMP5 complex	Human	BSEP-CHMP5 complex	liver	O95342;Q9NZZ3	8647;51510	MI:0019-coimmunoprecipitation;MI:0663-confocal microscopy	GO:0015125;GO:0015432;GO:0015721	bile acid transmembrane transporter activity;ABC-type bile acid transporter activity;bile acid and bile salt transport	None	None	33750401	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Bile salt export pump;Charged multivesicular body protein 5	ABCB11;CHMP5	BSEP;C9orf83 SNF7DC2
8644	DTNBP1 (splice variant 1A)-PRKDC-XRCC5-XRCC6 complex	Human	None	COS cells	P12956;P13010;P78527;Q96EV8-1	2547;7520;5591;84062	MI:0019-coimmunoprecipitation	GO:0006355	regulation of DNA-templated transcription	11.02.03.04	transcriptional control	19142223	The DNA-dependent protein kinase (DNA-PK) complex interacts only with dysbindin-1 splice isoforms A (Q96EV8-1) and B (Q96EV8-3), but not with C. isoforms A and B localized in nucleus, where the kinase complex exist, whereas the isoform C was found exclusively in cytosol. Furthermore, results of phosphorylation assay suggest that the DNA-PK complex phosphorylated dysbindin-1 isoforms A and B in cells. These observations suggest that DNA-PK regulates the dysbindin-1 isoforms A and B by phosphorylation in nucleus. Isoform C does not contain exons from 1 to 6.	None	Dysbindin 1A is a splice variant of DTNBP1 (Q96EV8-1).	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	X-ray repair cross-complementing protein 6;X-ray repair cross-complementing protein 5;DNA-dependent protein kinase catalytic subunit;Isoform 1 of Dysbindin	XRCC6;XRCC5;PRKDC;DTNBP1	G22P1;G22P2;HYRC HYRC1;BLOC1S8
8645	PTPN6-VAV1 complex	Human	PTP1C-VAV complex	P815 cells	P15498;P29350	7409;5777	MI:0019-coimmunoprecipitation	GO:0046579;GO:0060218	positive regulation of Ras protein signal transduction;hematopoietic stem cell differentiation	None	None	8632004	In stimulated, steel factor-treated P815 cells the association of PTPN6 with VAV1 is increased. Steel factor treatment induced marked increases in VAV1 tyrosine phosphorylation in P815 cells. PTPN6 tyrosine phosphorylation was also increased in association with stimulation of these cells. Results implicate a role of the PTPN6-VAV1 complex in the activation of Ras or Ras-related signaling pathways.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Proto-oncogene vav;Tyrosine-protein phosphatase non-receptor type 6	VAV1;PTPN6	VAV;HCP,PTP1C
8647	GRB2-PTPN6-SOS1 complex	Human	None	P815 cells	P29350;P62993;Q07889	5777;2885;6654	MI:0019-coimmunoprecipitation	GO:0045931	positive regulation of mitotic cell cycle	None	None	8632004	PTPN6 interactions with Grb2 and SOS1 were examined in steel factor-treated cells, and, interactions between this phosphatase and both GRB2 and SOS1 were increased, following cell activation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Tyrosine-protein phosphatase non-receptor type 6;Growth factor receptor-bound protein 2;Son of sevenless homolog 1	PTPN6;GRB2;SOS1	HCP,PTP1C;ASH;None
8649	GRB2-MED28-NF2 complex	Human	GRB2-Merlin-Magicin complex	T-47D cells	P35240;P62993;Q9H204	4771;2885;80306	MI:0019-coimmunoprecipitation	GO:0005856;GO:0007166	cytoskeleton;cell surface receptor signaling pathway	70.04;30.05	cytoskeleton;transmembrane signal transduction	15467741	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Merlin;Growth factor receptor-bound protein 2;Mediator of RNA polymerase II transcription subunit 28	NF2;GRB2;MED28	SCH;ASH;EG1
8650	GOLGA7-ZDHHC9 complex	Human	GCP16-DHHC9 complex	HEK-293 cells	Q7Z5G4;Q9Y397	51125;51114	MI:0019-coimmunoprecipitation	GO:0016746;GO:0018345;GO:0005794	acyltransferase activity;protein palmitoylation;Golgi apparatus	70.08	Golgi	16000296	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Golgin subfamily A member 7;Palmitoyltransferase ZDHHC9	GOLGA7;ZDHHC9	GCP16;CXorf11 ZDHHC10 ZNF379 ZNF380
8651	GOLGA7-ZDHHC5 complex	Human	None	293T cells	Q7Z5G4;Q9C0B5	51125;25921	MI:0019-coimmunoprecipitation;MI:0047-far western blotting	GO:0043543;GO:0016746;GO:0005886	protein acylation;acyltransferase activity;plasma membrane	70.02	eukaryotic plasma membrane / membrane attached	31631010	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Golgin subfamily A member 7;Palmitoyltransferase ZDHHC5	GOLGA7;ZDHHC5	GCP16;KIAA1748 ZNF375
8652	GOLGA7B-ZDHHC5 complex	Human	None	HeLa cells	Q2TAP0;Q9C0B5	401647;25921	MI:0019-coimmunoprecipitation	GO:0018345;GO:0016409;GO:0002159;GO:0007155;GO:0005886	protein palmitoylation;palmitoyltransferase activity;desmosome assembly;cell adhesion;plasma membrane	34.07;70.02	cell adhesion;eukaryotic plasma membrane / membrane attached	31402609	To confirm that the interaction of DHHC5 and Golga7b occurs in vivo, the authors performed immunoprecipitations of endogenous DHHC5 and Golga7b from a mouse forebrain lysate.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Golgin subfamily A member 7B;Palmitoyltransferase ZDHHC5	GOLGA7B;ZDHHC5	C10orf132 C10orf133;KIAA1748 ZNF375
8654	GRB2-p36/p38-PLCG1-SOS1-ZAP70 complex	Human	None	Jurkat cells	P19174;P43403;P62993;Q07889	5335;7535;2885;6654	MI:0019-coimmunoprecipitation	GO:0050852	T cell receptor signaling pathway	None	None	7629168	None	None	One other subunit of the complex was found in the analysis, which has not been further characterized: p36/p38.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1;Tyrosine-protein kinase ZAP-70;Growth factor receptor-bound protein 2;Son of sevenless homolog 1	PLCG1;ZAP70;GRB2;SOS1	PLC1;SRK;ASH;None
8655	MyD88-SYK-TLR4 complex	Human	SYK-TLR4-MyD88 complex	THP-1 cells	O00206;P43405;Q99836	7099;6850;4615	MI:0019-coimmunoprecipitation	GO:0045087;GO:0002221;GO:0002224;GO:0034142;GO:0002755;GO:0042742;GO:0032496;GO:0051092;GO:0001819;GO:0032653;GO:0032655	innate immune response;pattern recognition receptor signaling pathway;toll-like receptor signaling pathway;toll-like receptor 4 signaling pathway;MyD88-dependent toll-like receptor signaling pathway;defense response to bacterium;response to lipopolysaccharide;positive regulation of NF-kappaB transcription factor activity;positive regulation of cytokine production;regulation of interleukin-10 production;regulation of interleukin-12 production	36.25.16.01	innate immune response (invertebrates and vertebrates)	17228323	Syk is a modulator of LPS-mediated TLR4 responses in human monocytic cells. Inhibition of SYK by piceatannol treatment abrogates the LPS-mediated IL10 and IL12 release.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Toll-like receptor 4;Tyrosine-protein kinase SYK;Myeloid differentiation primary response protein MyD88	TLR4;SYK;MYD88	None;None;None
8656	IRAK1-MYD88-SYK-TLR4 complex	Human	SYK-TLR4-MyD88-IRAK1 complex	THP-1 cells, LPS stimulated	O00206;P43405;P51617;Q99836	7099;6850;3654;4615	MI:0019-coimmunoprecipitation	GO:0042742;GO:0045087;GO:0002221;GO:0002224;GO:0002755;GO:0001819;GO:0051092;GO:0032653;GO:0032655;GO:0032496;GO:0034142	defense response to bacterium;innate immune response;pattern recognition receptor signaling pathway;toll-like receptor signaling pathway;MyD88-dependent toll-like receptor signaling pathway;positive regulation of cytokine production;positive regulation of NF-kappaB transcription factor activity;regulation of interleukin-10 production;regulation of interleukin-12 production;response to lipopolysaccharide;toll-like receptor 4 signaling pathway	36.25.16.01	innate immune response (invertebrates and vertebrates)	17228323	IRAK-1 is only transiently recruited to the complex within 1 min of LPS engagement and dissociates by 30 min.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Toll-like receptor 4;Tyrosine-protein kinase SYK;Interleukin-1 receptor-associated kinase 1;Myeloid differentiation primary response protein MyD88	TLR4;SYK;IRAK1;MYD88	None;None;IRAK;None
8658	ATG2B-TRAPPC11-WDR45 complex	Human	None	HeLa cells	Q7Z392;Q96BY7;Q9Y484	60684;55102;11152	MI:0019-coimmunoprecipitation	GO:1905146	lysosomal protein catabolic process	None	None	30843302	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Trafficking protein particle complex subunit 11;Autophagy-related protein 2 homolog B;WD repeat domain phosphoinositide-interacting protein 4	TRAPPC11;ATG2B;WDR45	C4orf41;C14orf103;WDRX1 WDRXI4 WIPI4
8661	HNRNPD (p42)-PIN1 complex	Human	AUF1 (p42)-PIN1 complex	human peripheral blood	Q13526;Q14103-2	5300;3184	MI:0019-coimmunoprecipitation	GO:0005125;GO:0005737;GO:0032604	cytokine activity;cytoplasm;granulocyte macrophage colony-stimulating factor production	40.02.03.01;70.03	cytokines (interleukines, colony stimulating factors, etc.);cytoplasm	16273101	Immunoprecipitation of eosinophil cytoplasmic lysates demonstrated an interaction between Pin1 and all four AUF1 isoforms. The data indicate that Pin1 is a critical regulator of cytokine mRNA turnover, which in turn controls the survival of activated eosinophils in the lungs of asthmatics. In addition, because AUF1 controls the decay of many other ARE mRNAs, Pin1 may be important in cytokine production by other activated cells as well.	None	Pin1 is a key mediator of GM-CSF production and activated in vivo after allergen challenge. AUF1 / HNRNPD contains 4 isoforms/splice variants (isoform1=p45=Dx9=355aa, isoform2=p42=Dx4=336aa, isoform3=p40=Dx7=306aa, isoform4=p37=287aa).	Homo sapiens (Human);Homo sapiens (Human)	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1;Isoform 2 of Heterogeneous nuclear ribonucleoprotein D0	PIN1;HNRNPD	None;AUF1 HNRPD
8662	HNRNPD (p40)-PIN1 complex	Human	AUF1 (p40)-PIN1 complex	human peripheral blood	Q13526;Q14103-3	5300;3184	MI:0019-coimmunoprecipitation	GO:0005125;GO:0005737;GO:0032604	cytokine activity;cytoplasm;granulocyte macrophage colony-stimulating factor production	40.02.03.01;70.03	cytokines (interleukines, colony stimulating factors, etc.);cytoplasm	16273101	Immunoprecipitation of eosinophil cytoplasmic lysates demonstrated an interaction between Pin1 and all four AUF1 isoforms. The data indicate that Pin1 is a critical regulator of cytokine mRNA turnover, which in turn controls the survival of activated eosinophils in the lungs of asthmatics. In addition, because AUF1 controls the decay of many other ARE mRNAs, Pin1 may be important in cytokine production by other activated cells as well.	None	Pin1 is a key mediator of GM-CSF production and activated in vivo after allergen challenge. AUF1 / HNRNPD contains 4 isoforms/splice variants (isoform1=p45=Dx9=355aa, isoform2=p42=Dx4=336aa, isoform3=p40=Dx7=306aa, isoform4=p37=287aa).	Homo sapiens (Human);Homo sapiens (Human)	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1;Isoform 3 of Heterogeneous nuclear ribonucleoprotein D0	PIN1;HNRNPD	None;AUF1 HNRPD
8663	HNRNPD (p37)-PIN1 complex	Human	AUF1 (p37)-PIN1 complex	human peripheral blood	Q13526;Q14103-4	5300;3184	MI:0019-coimmunoprecipitation	GO:0005125;GO:0005737;GO:0032604	cytokine activity;cytoplasm;granulocyte macrophage colony-stimulating factor production	40.02.03.01;70.03	cytokines (interleukines, colony stimulating factors, etc.);cytoplasm	16273101	Immunoprecipitation of eosinophil cytoplasmic lysates demonstrated an interaction between Pin1 and all four AUF1 isoforms. The data indicate that Pin1 is a critical regulator of cytokine mRNA turnover, which in turn controls the survival of activated eosinophils in the lungs of asthmatics. In addition, because AUF1 controls the decay of many other ARE mRNAs, Pin1 may be important in cytokine production by other activated cells as well.	None	Pin1 is a key mediator of GM-CSF production and activated in vivo after allergen challenge. AUF1 / HNRNPD contains 4 isoforms/splice variants (isoform1=p45=Dx9=355aa, isoform2=p42=Dx4=336aa, isoform3=p40=Dx7=306aa, isoform4=p37=287aa).	Homo sapiens (Human);Homo sapiens (Human)	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1;Isoform 4 of Heterogeneous nuclear ribonucleoprotein D0	PIN1;HNRNPD	None;AUF1 HNRPD
8664	KPNA2-NUP50 complex	Human	Inportin alpha-Npap60L complex	HeLa cells	P52292;Q9UKX7-1	3838;10762	MI:0019-coimmunoprecipitation;MI:0416-fluorescence microscopy	GO:0006606;GO:0005634	protein import into nucleus;nucleus	70.10	nucleus	20016008	In humans, there are two NUP50 (Npap60) isoforms: the long (Npap60L) and short (Npap60S) forms. Npap60S stabilizes the binding of importin alpha to classical NLS-cargo, whereas Npap60L promotes the release of NLS-cargo from importin alpha.	None	Endogenous Npap60 localizes mainly to the nucleus.	Homo sapiens (Human);Homo sapiens (Human)	Importin subunit alpha-1;Isoform 1 of Nuclear pore complex protein Nup50	KPNA2;NUP50	RCH1, SRP1;NPAP60L
8665	KPNA2-NUP50 complex	Human	Importin alpha-Npap60S complex	HeLa cells	P52292;Q9UKX7-2	3838;10762	MI:0019-coimmunoprecipitation;MI:0416-fluorescence microscopy	GO:0006606;GO:0005634	protein import into nucleus;nucleus	70.10	nucleus	20016008	In humans, there are two NUP50 (Npap60) isoforms: the long (Npap60L) and short (Npap60S) forms. Npap60S stabilizes the binding of importin alpha to classical NLS-cargo, whereas Npap60L promotes the release of NLS-cargo from importin alpha.	None	Endogenous Npap60 localizes mainly to the nucleus.	Homo sapiens (Human);Homo sapiens (Human)	Importin subunit alpha-1;Isoform 2 of Nuclear pore complex protein Nup50	KPNA2;NUP50	RCH1, SRP1;NPAP60L
8666	KPNA4-KPNB1 complex	Human	Importin alpha3-importin beta complex	in vitro	O00629;Q14974	3840;;3837	MI:0416-fluorescence microscopy;MI:0107-surface plasmon resonance	GO:0006606;GO:0005737;GO:0005634	protein import into nucleus;cytoplasm;nucleus	70.03;70.10	cytoplasm;nucleus	10523667	The KPNA4-KPNB1 complex was shown to perform the nuclear import of proteins such as the shuttling RNA-binding protein hnRNP K and the chromatin-bound protein RCC1.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Importin subunit alpha-3;Importin subunit beta-1	KPNA4;KPNB1	QIP1;NTF97
8667	KPNA3-KPNB1 complex	Human	Importin alpha4-importin beta complex	in vitro	O00505;Q14974	None;3837	MI:0416-fluorescence microscopy;MI:0107-surface plasmon resonance	GO:0006606;GO:0005737;GO:0005634	protein import into nucleus;cytoplasm;nucleus	70.03;70.10	cytoplasm;nucleus	10523667	The KPNA3-KPNB1 complex was shown to perform the nuclear import of proteins such as the shuttling RNA-binding protein hnRNP K and the chromatin-bound protein RCC1.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Importin subunit alpha-4;Importin subunit beta-1	KPNA3;KPNB1	QIP2;NTF97
8668	KPNA1-KPNB1 complex	Human	Importin alpha5-importin beta complex	in vitro	P52294;Q14974	3836;3837	MI:0416-fluorescence microscopy;MI:0107-surface plasmon resonance	GO:0006606;GO:0005737;GO:0005634	protein import into nucleus;cytoplasm;nucleus	70.03;70.10	cytoplasm;nucleus	10523667	The KPNA1-KPNB1 complex was shown to perform the nuclear import of proteins such as the shuttling RNA-binding protein hnRNP K and the chromatin-bound protein RCC1.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Importin subunit alpha-5;Importin subunit beta-1	KPNA1;KPNB1	RCH2;NTF97
8669	KPNA6-KPNB1 complex	Human	Importin alpha7-importin beta complex	in vitro	O60684;Q14974	23633;;3837	MI:0416-fluorescence microscopy;MI:0107-surface plasmon resonance	GO:0006606;GO:0005737;GO:0005634	protein import into nucleus;cytoplasm;nucleus	70.03;70.10	cytoplasm;nucleus	10523667	The KPNA6-KPNB1 complex was shown to perform the nuclear import of proteins such as the shuttling RNA-binding protein hnRNP K and the chromatin-bound protein RCC1.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Importin subunit alpha-7;Importin subunit beta-1	KPNA6;KPNB1	IPOA7;NTF97
8670	CSE1L-KPNA4-RAN complex	Human	CAS-Importin alpha3-RanGTP complex	in vitro	O00629;P55060;P62826	3840;;1434;5901	MI:0400-affinity technology	GO:0005737;GO:0005634;GO:0006611	cytoplasm;nucleus;protein export from nucleus	70.03;70.10	cytoplasm;nucleus	10523667	The the return of importin alpha proteins from the nucleus into the cytoplasm is mediated by the nuclear export factor CSE1L (CAS), which binds to importin alpha proteins preferentially in the presence of RanGTP.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Importin subunit alpha-3;Exportin-2;GTP-binding nuclear protein Ran	KPNA4;CSE1L;RAN	QIP1;CAS XPO2;ARA24
8671	CSE1L-KPNA3-RAN complex	Human	CAS-Importin alpha4-RanGTP complex	in vitro	O00505;P55060;P62826	None;1434;5901	MI:0400-affinity technology	GO:0005737;GO:0005634;GO:0006611	cytoplasm;nucleus;protein export from nucleus	70.03;70.10	cytoplasm;nucleus	10523667	The the return of importin alpha proteins from the nucleus into the cytoplasm is mediated by the nuclear export factor CSE1L (CAS), which binds to importin alpha proteins preferentially in the presence of RanGTP.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Importin subunit alpha-4;Exportin-2;GTP-binding nuclear protein Ran	KPNA3;CSE1L;RAN	QIP2;CAS XPO2;ARA24
8672	CSE1L-KPNA1-RAN complex	Human	CAS-Importin alpha5-RanGTP complex	in vitro	P52294;P55060;P62826	3836;1434;5901	MI:0400-affinity technology	GO:0005737;GO:0005634;GO:0006611	cytoplasm;nucleus;protein export from nucleus	70.03;70.10	cytoplasm;nucleus	10523667	The the return of importin alpha proteins from the nucleus into the cytoplasm is mediated by the nuclear export factor CSE1L (CAS), which binds to importin alpha proteins preferentially in the presence of RanGTP.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Importin subunit alpha-5;Exportin-2;GTP-binding nuclear protein Ran	KPNA1;CSE1L;RAN	RCH2;CAS XPO2;ARA24
8673	CSE1L-KPNA6-RAN complex	Human	CAS-Importin alpha7-RanGTP complex	in vitro	O60684;P55060;P62826	23633;;1434;5901	MI:0400-affinity technology	GO:0005737;GO:0005634;GO:0006611	cytoplasm;nucleus;protein export from nucleus	70.03;70.10	cytoplasm;nucleus	10523667	The the return of importin alpha proteins from the nucleus into the cytoplasm is mediated by the nuclear export factor CSE1L (CAS), which binds to importin alpha proteins preferentially in the presence of RanGTP.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Importin subunit alpha-7;Exportin-2;GTP-binding nuclear protein Ran	KPNA6;CSE1L;RAN	IPOA7;CAS XPO2;ARA24
8674	Nuclear pore complex	Human	None	HeLa cells; HEK293 cells	O15504;O75694;P12270;P35658;P37198;P49790;P49792;P52948;P55735;P57740;P78406;Q12769;Q53GS7;Q5SRE5;Q7Z3B4;Q8N1F7;Q8NFH3;Q8NFH4;Q8NFH5;Q8TEM1;Q8WUM0;Q8WYP5;Q92621;Q96EE3;Q96HA1;Q99567;Q9BTX1;Q9BVL2;Q9BW27;Q9NRG9;Q9UKX7	11097;9631;None;None;23636;;9972;;5903;4928;6396;57122;8480;;23279;2733;23511;;53371;;9688;348995;79023;129401;;23225;;55746;25909;;None;81929;9883;;4927;;55706;;9818;;79902;None;10762;	MI:0069-mass spectrometry studies of complexes	GO:0051169;GO:0005635	nuclear transport;nuclear envelope	20.09.01;70.10.05	nuclear transport;nuclear membrane	23511206	The nuclear pore complex conducts the transport of molecules in and out of the nucleus. It is built from nucleoporins (Nups) that assemble in multiple copies to form an eight-fold rotationally symmetric complex. Nups first assemble into hetero-oligomeric subcomplexes, which in turn, serve as modular building blocks to form larger structures.	The expression of NUP210 (Gp210) and other subunits varies spatially between different human cancer cell lines, at both the transcript and protein level.	The composition of the nuclear pore complexes was found to vary across different human cell lines. The sum of the molecular weight of all copies of all Nups in the study was 110+/-10 MDa.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Nucleoporin NUP42;Nuclear pore complex protein Nup155;Nucleoprotein TPR;Nuclear pore complex protein Nup214;Nuclear pore glycoprotein p62;Nuclear pore complex protein Nup153;E3 SUMO-protein ligase RanBP2;Nuclear pore complex protein Nup98-Nup96;Protein SEC13 homolog;Nuclear pore complex protein Nup107;mRNA export factor RAE1;Nuclear pore complex protein Nup160;mRNA export factor GLE1;Nucleoporin NUP188;Nucleoporin p54;Nuclear pore complex protein Nup93;Nucleoporin Nup43;Nucleoporin Nup37;Nucleoporin NUP35;Nuclear pore membrane glycoprotein 210;Nuclear pore complex protein Nup133;Protein ELYS;Nuclear pore complex protein Nup205;Nucleoporin SEH1;Nuclear envelope pore membrane protein POM 121;Nuclear pore complex protein Nup88;Nucleoporin NDC1;Nucleoporin p58/p45;Nuclear pore complex protein Nup85;Aladin;Nuclear pore complex protein Nup50	NUP42;NUP155;TPR;NUP214;NUP62;NUP153;RANBP2;NUP98;SEC13;NUP107;RAE1;NUP160;GLE1;NUP188;NUP54;NUP93;NUP43;NUP37;NUP35;NUP210;NUP133;AHCTF1;NUP205;SEH1L;POM121;NUP88;NDC1;NUP58;NUP85;AAAS;NUP50	CG1 NUPL2;KIAA0791;None;CAIN CAN KIAA0023;None;None;NUP358;ADAR2;D3S1231E SEC13A SEC13L1 SEC13R;None;MRNP41;KIAA0197 NUP120;GLE1L;KIAA0169;None;KIAA0095;None;None;MP44 NUP53;KIAA0906;None;ELYS TMBS62;C7orf14 KIAA0225;SEC13L SEH1;KIAA0618 NUP121 POM121A;None;TMEM48;KIAA0410 NUPL1;NUP75 PCNT1;ADRACALA;NPAP60L
8675	MIB subcomplex (MTX2, MTX3, SAMM50), mitochondrial	Human	mitochondrial intermembrane space bridging subcomplex	human skin fibroblasts	O75431;Q5HYI7;Q9Y512	10651;None;25813	MI:0069-mass spectrometry studies of complexes	GO:0042407;GO:0044284;GO:0001401;GO:0006626;GO:0006839;GO:0005739	cristae formation;mitochondrial crista junction;SAM complex;protein targeting to mitochondrion;mitochondrial transport;mitochondrion	20.09.04;70.16	mitochondrial transport;mitochondrion	26477565	The SAMM50/MTX2/MTX3 MIB subcomplex is sufficient to recruit the MICOS complex to form the MIB centerpiece structure (PMID:26477565). SAM50 is a critical stabilizing protein of the MIB complex responsible for protein transport, assembly of respiratory chain complexes and regulation of cristae integrity (PMID:34385433).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Metaxin-2;Metaxin-3;Sorting and assembly machinery component 50 homolog	MTX2;MTX3;SAMM50	None;None;SAM50
8676	MIB subcomplex (DNAJC11, MTX1), mitochondrial	Human	mitochondrial intermembrane space bridging subcomplex	human skin fibroblasts	Q13505;Q9NVH1	4580;55735	MI:0069-mass spectrometry studies of complexes	GO:0042407;GO:0044284	cristae formation;mitochondrial crista junction	None	None	26477565	Addition of the MIB subcomplex MTX1/DNAJC11 resulted in the full size MIB complex.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Metaxin-1;DnaJ homolog subfamily C member 11	MTX1;DNAJC11	MTX MTXN;None
8677	TLR3-associated signaling complex	Human	TLR3-TRIF-RIP1-FADD-cFLIP-Casp8 complex; TLR3-TRIF-RIP1-FADD-cFLIP(L)-cFLIP(S)-Casp8 complex	DU145 cells, influenza virus A stimulated	O15455;O15519-1;O15519-2;Q13158;Q13546;Q14790;Q8IUC6	7098;8837;8837;8772;8737;841;148022	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0045087;GO:0002221;GO:0002224;GO:0034138;GO:0051607;GO:0042981	innate immune response;pattern recognition receptor signaling pathway;toll-like receptor signaling pathway;toll-like receptor 3 signaling pathway;defense response to virus;regulation of apoptotic process	36.25.16.01	innate immune response (invertebrates and vertebrates)	23449395	In untreated DU145 cells and in cells stimulated with IL-24 alone, only TRIF was associated with TLR3. Stimulation of cells by influenza A virus (hi-delNS1) resulted in the formation of this TLR3-associated signaling complex. cFLIP was absent from the complex  (CORUM-ID 8679) when cells were additionally co-stimulated with IL-24 and pronounced caspase-8 activation was observed. (PMID:23449395)	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Toll-like receptor 3;Isoform 1 of CASP8 and FADD-like apoptosis regulator;Isoform 2 of CASP8 and FADD-like apoptosis regulator;FAS-associated death domain protein;Receptor-interacting serine/threonine-protein kinase 1;Caspase-8;TIR domain-containing adapter molecule 1	TLR3;CFLAR;CFLAR;FADD;RIPK1;CASP8;TICAM1	None;CASH CASP8AP1 CLARP MRIT;CASH CASP8AP1 CLARP MRIT;MORT1;RIP, RIP1;MCH5;PRVTIRB TRIF
8678	TLR3 death-signaling complex	Human	TLR3 to caspase-8-activating DISC-like complex	NCI-H292 cells, Poly(I:C) treated	O15455;O15519-1;Q13158;Q13546;Q14790;Q8IUC6;Q92851	7098;8837;8772;8737;841;148022;843	MI:0004-affinity chromatography technology;MI:0019-coimmunoprecipitation	GO:0043331;GO:0034138;GO:0045087;GO:0002221;GO:0002224;GO:0043065;GO:0006952	response to dsRNA;toll-like receptor 3 signaling pathway;innate immune response;pattern recognition receptor signaling pathway;toll-like receptor signaling pathway;positive regulation of apoptotic process;defense response	36.25.16.01	innate immune response (invertebrates and vertebrates)	22421964	Activation of TLR3 by dsRNA induces the formation of an atypical caspase-8-containing complex that is devoid of classical death receptors of the TNFR superfamily, but instead is physically associated to TLR3. (PMID:22421964). Lack of the short-lived cFLIP in this complex leads to the activation of caspase-8 and, subsequently, caspase-3-mediated apoptotic cell death (PMID:23449395).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Toll-like receptor 3;Isoform 1 of CASP8 and FADD-like apoptosis regulator;FAS-associated death domain protein;Receptor-interacting serine/threonine-protein kinase 1;Caspase-8;TIR domain-containing adapter molecule 1;Caspase-10	TLR3;CFLAR;FADD;RIPK1;CASP8;TICAM1;CASP10	None;CASH CASP8AP1 CLARP MRIT;MORT1;RIP, RIP1;MCH5;PRVTIRB TRIF;MCH4
8679	TLR3-DISC complex, atypical	Human	TLR3-associated death-inducing signaling complex, atypical	DU145 cells, infected with IL-24 encoding influenza A virus	O15455;Q13158;Q13546;Q14790;Q8IUC6	7098;8772;8737;841;148022	MI:0019-coimmunoprecipitation	GO:0006915;GO:0002224;GO:0002221;GO:0045087;GO:0051607;GO:0034138	apoptotic process;toll-like receptor signaling pathway;pattern recognition receptor signaling pathway;innate immune response;defense response to virus;toll-like receptor 3 signaling pathway	40.10.02;36.25.16.01	apoptosis (type I programmed cell death);innate immune response (invertebrates and vertebrates)	23449395	In untreated DU145 cells and in cells stimulated with IL-24 alone, only TRIF was associated with TLR3. Stimulation of cells by influenza A virus (hi-delNS1) resulted in the formation of a complex that contained TLR3, TRIF, RIP1, FADD, cFLIPL, cFLIPS and pro-caspase-8 (CORUM-ID 8677). cFLIP was absent from the complex when cells were additionally co-stimulated with IL-24 and pronounced caspase-8 activation was observed. (PMID:23449395)	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Toll-like receptor 3;FAS-associated death domain protein;Receptor-interacting serine/threonine-protein kinase 1;Caspase-8;TIR domain-containing adapter molecule 1	TLR3;FADD;RIPK1;CASP8;TICAM1	None;MORT1;RIP, RIP1;MCH5;PRVTIRB TRIF
8681	IKBKG-MAVS-TRAF2 complex	Human	MAVS-TRAF2-NEMO complex	U2OS cells and HeLa S100	Q12933;Q7Z434;Q9Y6K9	7186;57506;8517	MI:0007-anti tag coimmunoprecipitation	GO:0051607;GO:0045087;GO:0002221;GO:0039529;GO:0043331;GO:0032481	defense response to virus;innate immune response;pattern recognition receptor signaling pathway;RIG-I signaling pathway;response to dsRNA;positive regulation of type I interferon production	36.25.16.01	innate immune response (invertebrates and vertebrates)	23951545	MAVS and TRAF2 form a MAVS-induced ubiquitination-dependent signaling complex with NEMO in vitro.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	TNF receptor-associated factor 2;Mitochondrial antiviral-signaling protein;NF-kappa-B essential modulator	TRAF2;MAVS;IKBKG	TRAP3;IPS1,KIAA1271,VISA;FIP3, NEMO
8682	DDX3X-IKBKE-MAVS-TRAF3 complex	Human	MAVS-TRAF3-DDX3-IKKepsilon complex	A549 cells, infected with Sendai virus	O00571;Q13114;Q14164;Q7Z434	1654;7187;9641;57506	MI:0007-anti tag coimmunoprecipitation	GO:0045087;GO:0002221;GO:0051607;GO:0032481;GO:0039529	innate immune response;pattern recognition receptor signaling pathway;defense response to virus;positive regulation of type I interferon production;RIG-I signaling pathway	36.25.16.01	innate immune response (invertebrates and vertebrates)	27980081	This complex is formed at 1 and 2h following SeV infection. DDX3 is required to facilitate TRAF3 recruitment to MAVS, where it might subsequently interact with IKKepsilon.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	ATP-dependent RNA helicase DDX3X;TNF receptor-associated factor 3;Inhibitor of nuclear factor kappa-B kinase subunit epsilon;Mitochondrial antiviral-signaling protein	DDX3X;TRAF3;IKBKE;MAVS	DBX DDX3;CAP-1 CRAF1 TRAFAMN;IKKE IKKI KIAA0151;IPS1,KIAA1271,VISA
8683	HCN2-HCN4 complex	Human	None	HEK293 cells	Q9UL51;Q9Y3Q4	610;;10021;	MI:0019-coimmunoprecipitation	GO:0005249;GO:0008076	voltage-gated potassium channel activity;voltage-gated potassium channel complex	None	None	12928435	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2;Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	HCN2;HCN4	BCNG2;None
8684	HCN1-HCN3 complex	Human	None	HEK293 cells	O60741;Q9P1Z3	348980;;57657;	MI:0019-coimmunoprecipitation	GO:0005249;GO:0008076	voltage-gated potassium channel activity;voltage-gated potassium channel complex	None	None	12928435	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1;Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3	HCN1;HCN3	BCNG1;KIAA1535
8685	HCN1-HCN4 complex	Human	None	HEK293 cells	O60741;Q9Y3Q4	348980;;10021;	MI:0019-coimmunoprecipitation	GO:0005249;GO:0008076	voltage-gated potassium channel activity;voltage-gated potassium channel complex	None	None	12928435	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1;Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	HCN1;HCN4	BCNG1;None
8686	HCN3-HCN4 complex	Human	None	HEK293 cells	Q9P1Z3;Q9Y3Q4	57657;;10021;	MI:0019-coimmunoprecipitation	GO:0005249;GO:0008076	voltage-gated potassium channel activity;voltage-gated potassium channel complex	None	None	12928435	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3;Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	HCN3;HCN4	KIAA1535;None
8691	PRKN-TOMM40 subcomplex, mitochondrial	Human	PARK2-TOM40 complex	HEK293T cells	O60260;O96008	5071;10452	MI:0055-fluorescent resonance energy transfer;MI:0096-pull down;MI:0113-western blot	GO:0000423;GO:0005741	mitophagy;mitochondrial outer membrane	70.16.01	mitochondrial outer membrane	24149440	Blockade of mitochondrial protein import triggers the recruitment of PARK2/PRKN, by PINK1, to the TOM machinery. PRKN interacts with the TOMM machinery in a PINK1-dependent manner and was required to promote the degradation of whole organelles by autophagy. Downregulation of TOMM40 triggers PARK2-dependent mitophagy.	Loss-of-function mutations in PARK2/PARKIN and PINK1 cause early-onset autosomal recessive Parkinson disease (PD). PD-causing PARK2 mutations weakened or disrupted the molecular interaction between PARK2 and specific TOMM subunits: the surface receptor, TOMM70A, and the channel protein, TOMM40. TOMM40 influences the age at onset of Alzheimer disease and changes in protein import efficiency have been reported in neurodegenerative conditions in humans and animal models.	None	Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase parkin;Mitochondrial import receptor subunit TOM40 homolog	PRKN;TOMM40	PARK2;C19orf1 PEREC1 TOM40
8692	PRKN-TOMM70 subcomplex, mitochondrial	Human	PARK2-TOMM70A complex	HEK293T cells	O60260;O94826	5071;9868	MI:0055-fluorescent resonance energy transfer;MI:0096-pull down;MI:0113-western blot	GO:0000423	mitophagy	None	None	24149440	Blockade of mitochondrial protein import triggers the recruitment of PARK2/PRKN, by PINK1, to the TOM machinery. PRKN interacts with the TOMM machinery in a PINK1-dependent manner and was required to promote the degradation of whole organelles by autophagy.	Loss-of-function mutations in PARK2/PARKIN and PINK1 cause early-onset autosomal recessive Parkinson disease (PD). PD-causing PARK2 mutations weakened or disrupted the molecular interaction between PARK2 and specific TOMM subunits: the surface receptor, TOMM70A, and the channel protein, TOMM40.	None	Homo sapiens (Human);Homo sapiens (Human)	E3 ubiquitin-protein ligase parkin;Mitochondrial import receptor subunit TOM70	PRKN;TOMM70	PARK2;KIAA0719 TOM70 TOMM70A
8693	DDX58-MAVS-TRIM31 complex	Human	RIG-I-MAVS-TRIM31 complex	HEK293T and A549 cells, infected with SEV cells	O95786;Q7Z434;Q9BZY9	23586;57506;11074	MI:0006-anti bait coimmunoprecipitation	GO:0045087;GO:0002221;GO:0039529;GO:0051607;GO:0032481;GO:0019048	innate immune response;pattern recognition receptor signaling pathway;RIG-I signaling pathway;defense response to virus;positive regulation of type I interferon production;modulation by virus of host process	36.25.16.01	innate immune response (invertebrates and vertebrates)	34239064	TRIM31 and RIG-I associate with endogenous MAVS after infection with SeV. This association is impeded by SARS2-N protein (SARS2-NP). The authors confirmed that ectopic SARS2-NP expression inhibits TRIM31-mediated-poly-ubiquitination and aggregation of MAVS leading to down-regulation of the interferon response favouring the infectious process.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Antiviral innate immune response receptor RIG-I;Mitochondrial antiviral-signaling protein;E3 ubiquitin-protein ligase TRIM31	DDX58;MAVS;TRIM31	None;IPS1,KIAA1271,VISA;C6orf13 RNF
8694	IKBKE-MAVS-TBK1 complex	Human	MAVS-TBK1-IKKepsilon complex	HEK293T and A549 cells, infected with SeV	Q14164;Q7Z434;Q9UHD2	9641;57506;29110	MI:0006-anti bait coimmunoprecipitation	GO:0045087;GO:0002221;GO:0039529;GO:0051607;GO:0032481;GO:0019048	innate immune response;pattern recognition receptor signaling pathway;RIG-I signaling pathway;defense response to virus;positive regulation of type I interferon production;modulation by virus of host process	36.25.16.01	innate immune response (invertebrates and vertebrates)	34239064	MAVS aggregation induced by SeV virus infection recruits TBK1 and IKKepsilon for phosphorylation and activation. SARS-CoV-2 N protein interfered with the association between MAVS and TBK1-IKKepsilon and disrupts MAVS-TBK1-IKKepsilon complex formation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Inhibitor of nuclear factor kappa-B kinase subunit epsilon;Mitochondrial antiviral-signaling protein;Serine/threonine-protein kinase TBK1	IKBKE;MAVS;TBK1	IKKE IKKI KIAA0151;IPS1,KIAA1271,VISA;NAK
8695	DDX58-MAVS-TRAF3-TBK1 complex	Human	RIG-I-MAVS-TRAF3-TBK1 complex	HEK293T cells, infected with SeV	O95786;Q13114;Q7Z434;Q9UHD2	23586;7187;57506;29110	MI:0019-coimmunoprecipitation	GO:0045087;GO:0002221;GO:0039529;GO:0051607;GO:0043331;GO:0032481;GO:0019048	innate immune response;pattern recognition receptor signaling pathway;RIG-I signaling pathway;defense response to virus;response to dsRNA;positive regulation of type I interferon production;modulation by virus of host process	36.25.16.01	innate immune response (invertebrates and vertebrates)	33372174	SARS-CoV-2 M protein inhibits the production of type I and III IFNs induced by the cytosolic dsRNA-sensing pathway mediated by RIG-I-MAVS signaling. SARS-CoV-2 M protein prevents the RIG-I-MAVS, MAVS-TBK1, and TRAF3-TBK1 interactions and the formation of the complex containing RIG-I, MAVS, TRAF3, and TBK1. (PMID:33372174)	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Antiviral innate immune response receptor RIG-I;TNF receptor-associated factor 3;Mitochondrial antiviral-signaling protein;Serine/threonine-protein kinase TBK1	DDX58;TRAF3;MAVS;TBK1	None;CAP-1 CRAF1 TRAFAMN;IPS1,KIAA1271,VISA;NAK
8696	DDX58-MAVS-PPP6C-TRIM14-WHIP complex	Human	RIG-I-MAVS-PPP6C-TRIM14-WHIP complex	THP-1 cells, infected with VSV (vesicular stomatitis virus)	O00743;O95786;Q14142;Q7Z434;Q96S55	5537;23586;9830;57506;56897	MI:0004-affinity chromatography technology	GO:0002221;GO:0045087;GO:0039529;GO:0051607;GO:0032481;GO:0005739;GO:0043331	pattern recognition receptor signaling pathway;innate immune response;RIG-I signaling pathway;defense response to virus;positive regulation of type I interferon production;mitochondrion;response to dsRNA	36.25.16.01;70.16	innate immune response (invertebrates and vertebrates);mitochondrion	29053956	The mitochondrion-associated and pre-existing WHIP-TRIM14-PPP6C complex (CORUM-ID:8319) bridges RIG-I and MAVS  after infection with VSV (vesicular stomatitis virus).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein phosphatase 6 catalytic subunit;Antiviral innate immune response receptor RIG-I;Tripartite motif-containing protein 14;Mitochondrial antiviral-signaling protein;ATPase WRNIP1	PPP6C;DDX58;TRIM14;MAVS;WRNIP1	PPP6;None;KIAA0129;IPS1,KIAA1271,VISA;WHIP
8697	GUCA1A-GUCY2D-RD3 complex	Human	GC1-GCAP1-RD3 complex	COS7 cells	P43080;Q02846;Q7Z3Z2	2978;3000;343035	MI:0019-coimmunoprecipitation	GO:0007601;GO:1903546	visual perception;protein localization to photoreceptor outer segment	34.11.01.03	visual transduction	25477517	None	The complex Is not properly formed and targeted to the photoreceptor outer segment in GUCY2D (GC1) mutants that cause Leber congenital amaurosis 1 (LCA1).	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Guanylyl cyclase-activating protein 1;Retinal guanylyl cyclase 1;Protein RD3	GUCA1A;GUCY2D;RD3	C6orf131 GCAP GCAP1 GUCA1;CORD6 GUC1A4 GUC2D RETGC RETGC1;C1orf36
8698	RIPK1-RIPK3 complex	Human	RIP1-RIP3 complex	HT-29 cells, treated with Smac mimetic and TNF-alpha	Q13546;Q9Y572	8737;11035	MI:0019-coimmunoprecipitation	GO:0034612;GO:0051607;GO:0006955;GO:0032481;GO:1990784;GO:0032088;GO:0045087;GO:0060544;GO:0019048	response to tumor necrosis factor;defense response to virus;immune response;positive regulation of type I interferon production;response to dsDNA;negative regulation of NF-kappaB transcription factor activity;innate immune response;regulation of necroptotic process;modulation by virus of host process	36.25.16;36.25.16.01	immune response;innate immune response (invertebrates and vertebrates)	19524512	RIPK3 is recruited to RIPK1 to form a necrosis-inducing complex (PMID:19524512). Epstein-Barr virus (EBV) and  Herpes simplex virus (HSV) have evolved mechanisms inhibiting necroptosis to overcome host antiviral defense. EBV-LMP1 protein interacts with RIPK1 and RIPK3 and disrupts the formation of the RIPK1-RIPK3 complex via inhibition of K63-linked polyubiquitination of RIPK3 (PMID:29352166). HSV-1 and -2 R1 proteins suppress necroptosis by inhibiting the interaction between RIPK1 and RIPK3 (PMID:25674983).	None	None	Homo sapiens (Human);Homo sapiens (Human)	Receptor-interacting serine/threonine-protein kinase 1;Receptor-interacting serine/threonine-protein kinase 3	RIPK1;RIPK3	RIP, RIP1;RIP3
8699	CASP8-FADD-RIPK1-RIPK3 complex	Human	CASP8-FADD-RIP1-RIP3 complex	HT-29 cells, TNF-alpha, Smac mimetic and z-VAD treated	Q13158;Q13546;Q14790;Q9Y572	8772;8737;841;11035	MI:0007-anti tag coimmunoprecipitation	GO:0097300;GO:0034612	programmed necrotic cell death;response to tumor necrosis factor	None	None	19524512	If caspase-8 is inhibited after death receptor activation, RIPK3 forms a stable complex with RIPK1, FADD, CASP8 and transforms it to a pro-necrosis complex (PMID:19524512).	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	FAS-associated death domain protein;Receptor-interacting serine/threonine-protein kinase 1;Caspase-8;Receptor-interacting serine/threonine-protein kinase 3	FADD;RIPK1;CASP8;RIPK3	MORT1;RIP, RIP1;MCH5;RIP3
8700	HRAS-PPP1CC-SHOC2 complex	Human	None	in vitro	P01112;P36873;Q9UQ13	3265;5501;8036	MI:0071-molecular sieving;MI:0107-surface plasmon resonance	GO:0043408;GO:0007265	regulation of MAPK cascade;Ras protein signal transduction	None	None	35768504	SHOC2 is as an essential scaffolding protein that engages both PP1C and RAS to dephosphorylate RAF N-terminal phosphoserine.	Analyses show that fitness defects caused by SHOC2 inactivation in cancer cell lines are directly associated with the oncogenic activity of H/K/NRAS and are independent of MRAS.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	GTPase HRas;Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Leucine-rich repeat protein SHOC-2	HRAS;PPP1CC;SHOC2	HRAS1;None;KIAA0862
8701	KRAS-PPP1CC-SHOC2 complex	Human	None	in vitro	P01116;P36873;Q9UQ13	3845;5501;8036	MI:0071-molecular sieving;MI:0107-surface plasmon resonance;MI:0410-3D electron microscopy	GO:0043408;GO:0007265	regulation of MAPK cascade;Ras protein signal transduction	None	None	35768504	SHOC2 is as an essential scaffolding protein that engages both PP1C and RAS to dephosphorylate RAF N-terminal phosphoserine. MRAS(GCP) is the stronger binding partner in the SHOC2\u2013PP1C\u2013RAS complex among the isoforms tested.	Analyses show that fitness defects caused by SHOC2 inactivation in cancer cell lines are directly associated with the oncogenic activity of H/K/NRAS and are independent of MRAS.	A fraction of particles in the SHOC2-PP1C-MRAS cryo-EM dataset adopted a 2:2:2 hexameric complex (a dimer of SHOC2-PP1C-MRAS heterotrimers)	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	GTPase KRas;Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Leucine-rich repeat protein SHOC-2	KRAS;PPP1CC;SHOC2	KRAS2 RASK2;None;KIAA0862
8702	MRAS-PPP1CC-SHOC2 complex (trimer)	Human	None	in vitro	O14807;P36873;Q9UQ13	22808;5501;8036	MI:0071-molecular sieving;MI:0107-surface plasmon resonance;MI:0410-3D electron microscopy	GO:0043408;GO:0007265	regulation of MAPK cascade;Ras protein signal transduction	None	None	35768504	SHOC2 is as an essential scaffolding protein that engages both PP1C and RAS to dephosphorylate RAF N-terminal phosphoserine.	Analyses show that fitness defects caused by SHOC2 inactivation in cancer cell lines are directly associated with the oncogenic activity of H/K/NRAS and are independent of MRAS.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Ras-related protein M-Ras;Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Leucine-rich repeat protein SHOC-2	MRAS;PPP1CC;SHOC2	RRAS3;None;KIAA0862
8703	NRAS-PPP1CC-SHOC2 complex	Human	None	in vitro	P01111;P36873;Q9UQ13	None;5501;8036	MI:0071-molecular sieving;MI:0107-surface plasmon resonance	GO:0043408;GO:0007265	regulation of MAPK cascade;Ras protein signal transduction	None	None	35768504	SHOC2 is as an essential scaffolding protein that engages both PP1C and RAS to dephosphorylate RAF N-terminal phosphoserine.	Analyses show that fitness defects caused by SHOC2 inactivation in cancer cell lines are directly associated with the oncogenic activity of H/K/NRAS and are independent of MRAS.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	GTPase NRas;Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Leucine-rich repeat protein SHOC-2	NRAS;PPP1CC;SHOC2	HRAS1;None;KIAA0862
8704	MRAS-PPP1CC-SHOC2 complex (hexamer)	Human	None	in vitro	O14807;P36873;Q9UQ13	22808;5501;8036	MI:0071-molecular sieving;MI:0107-surface plasmon resonance;MI:0410-3D electron microscopy	GO:0043408;GO:0007265	regulation of MAPK cascade;Ras protein signal transduction	None	None	35768504	SHOC2 is as an essential scaffolding protein that engages both PP1C and RAS to dephosphorylate RAF N-terminal phosphoserine.	Analyses show that fitness defects caused by SHOC2 inactivation in cancer cell lines are directly associated with the oncogenic activity of H/K/NRAS and are independent of MRAS.	A fraction of particles in the SHOC2-PP1C-MRAS cryo-EM dataset adopted a 2:2:2 hexameric complex (a dimer of SHOC2-PP1C-MRAS heterotrimers)	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Ras-related protein M-Ras;Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Leucine-rich repeat protein SHOC-2	MRAS;PPP1CC;SHOC2	RRAS3;None;KIAA0862
8705	RIPK1-TLR3-TRIF complex	Human	RIP1-TLR3-TRIF complex	HEK293T cells	O15455;Q13546;Q8IUC6	7098;8737;148022	MI:0019-coimmunoprecipitation	GO:0051092;GO:0043331;GO:0051607;GO:0035666;GO:0034138;GO:0045087;GO:0002221;GO:0002224;GO:0002756	positive regulation of NF-kappaB transcription factor activity;response to dsRNA;defense response to virus;TRIF-dependent toll-like receptor signaling pathway;toll-like receptor 3 signaling pathway;innate immune response;pattern recognition receptor signaling pathway;toll-like receptor signaling pathway;MyD88-independent toll-like receptor signaling pathway	36.25.16.01	innate immune response (invertebrates and vertebrates)	15064760	TRIF functions as adaptor for TLR3 and RIPK1.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Toll-like receptor 3;Receptor-interacting serine/threonine-protein kinase 1;TIR domain-containing adapter molecule 1	TLR3;RIPK1;TICAM1	None;RIP, RIP1;PRVTIRB TRIF
8706	Optn-Tbk1 complex	Human	None	bone marrow-derived macrophages	Q8K3K8;Q9WUN2	71648;56480	MI:0019-coimmunoprecipitation	GO:0043331;GO:0032496;GO:0032728;GO:0002221;GO:0045087;GO:0034121;GO:0039535;GO:0051607;GO:0042742	response to dsRNA;response to lipopolysaccharide;positive regulation of interferon-beta production;pattern recognition receptor signaling pathway;innate immune response;regulation of toll-like receptor signaling pathway;regulation of RIG-I signaling pathway;defense response to virus;defense response to bacterium	36.25.16.01	innate immune response (invertebrates and vertebrates)	28159912	Ubiquitination of OPTN is required for the robust phosphorylation and activation of the OPTN-TBK1 complex (PMID:28159912). TBK1-mediated phosphorylation of OPTN is a crucial event in the restriction of intracellular growth of L. monocytogenes (PMID:28872615).	Loss-of-function mutations in optineurin (OPTN) are involved in the development of amyotrophic lateral sclerosis. Sudies indicate that disruption of OPTN-TBK1 complex-mediated IFN-beta production leads to an immune failure which could predispose to neurodegeneration. (PMID:30017954). Mutations in the OPTN gene have been found to cause familial primary open angle glaucoma (POAG). The OPTN[E50K] mutant associated with POAG displayed strikingly enhanced binding to TBK1, suggesting that this interaction may contribute to familial POAG. (PMID:18307994)	None	Mus musculus (Mouse);Mus musculus (Mouse)	Optineurin;Serine/threonine-protein kinase TBK1	Optn;Tbk1	None;None
8707	OPTN-TBK1 complex	Human	None	HEK293 cells	Q96CV9;Q9UHD2	10133;29110	MI:0019-coimmunoprecipitation	GO:0042742;GO:0051607;GO:0045087;GO:0002221;GO:0032728;GO:0043331;GO:0032496	defense response to bacterium;defense response to virus;innate immune response;pattern recognition receptor signaling pathway;positive regulation of interferon-beta production;response to dsRNA;response to lipopolysaccharide	36.25.16.01	innate immune response (invertebrates and vertebrates)	18307994	Ubiquitination of OPTN is required for the robust phosphorylation and activation of the OPTN-TBK1 complex (PMID:28159912). TBK1-mediated phosphorylation of OPTN is a crucial event in the restriction of intracellular growth of L. monocytogenes (PMID:28872615).	Loss-of-function mutations in optineurin (OPTN) are involved in the development of amyotrophic lateral sclerosis. Studies indicate that disruption of OPTN-TBK1 complex-mediated IFN-beta production leads to an immune failure which could predispose to neurodegeneration. (PMID:30017954). Mutations in the OPTN gene have been found to cause familial primary open angle glaucoma (POAG). The OPTN[E50K] mutant associated with POAG displayed strikingly enhanced binding to TBK1, suggesting that this interaction may contribute to familial POAG. (PMID:18307994)	None	Homo sapiens (Human);Homo sapiens (Human)	Optineurin;Serine/threonine-protein kinase TBK1	OPTN;TBK1	FIP2 GLC1E HIP7 HYPL NRP;NAK
8708	TLR4-TLR5 complex	Human	None	transfected COS-1 cells	O00206;O60602	7099;7100;	MI:0007-anti tag coimmunoprecipitation	GO:0042742;GO:0032728;GO:0045087;GO:0002221;GO:0002224;GO:0002537	defense response to bacterium;positive regulation of interferon-beta production;innate immune response;pattern recognition receptor signaling pathway;toll-like receptor signaling pathway;nitric oxide production involved in inflammatory response	36.25.16.01	innate immune response (invertebrates and vertebrates)	12794153	TLR5 forms homomeric complexes as well as heteromeric complexes with TLR4. Production of NO induced by Gram-negative flagellin is dependent on TLR5-TLR4 complexes.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Toll-like receptor 4;Toll-like receptor 5	TLR4;TLR5	None;TIL3
8709	MYD88-TLR4 complex	Human	None	monocytes, LPS-induced	O00206;Q99836	7099;4615	MI:0006-anti bait coimmunoprecipitation	GO:0032496;GO:0002224;GO:0034142;GO:0002221;GO:0045087	response to lipopolysaccharide;toll-like receptor signaling pathway;toll-like receptor 4 signaling pathway;pattern recognition receptor signaling pathway;innate immune response	36.25.16.01	innate immune response (invertebrates and vertebrates)	12391239	LPS-induced formation of the TLR4-MyD88 complex is impaired in LPS-tolerant human monocytes.	Tolerance against endotoxins, such as LPS, is a common phenomenon observed in blood from sepsis patients. (PMID:10811644)	None	Homo sapiens (Human);Homo sapiens (Human)	Toll-like receptor 4;Myeloid differentiation primary response protein MyD88	TLR4;MYD88	None;None
8710	ALYREF-MYCN complex	Human	None	HEK293 cells	P04198;Q86V81	4613;;10189	MI:0007-anti tag coimmunoprecipitation	GO:0005634;GO:0045893	nucleus;positive regulation of DNA-templated transcription	70.10;11.02.03.04.01	nucleus;transcription activation	33767157	The ALYREF-MYCN complex upregulates USP3 expression. USP3 regulates MYCN expression through its deubiquitinase activity.	The MYCN expression profile is one of the most robust and significant prognostic markers for neuroblastoma outcome. The ALYREF-MYCN complex drives neuroblastoma tumorigenesis through effects on USP3 and MYCN stability.	None	Homo sapiens (Human);Homo sapiens (Human)	N-myc proto-oncogene protein;THO complex subunit 4	MYCN;ALYREF	BHLHE37 NMYC;ALY BEF THOC4
8711	MYCN-SIRT1 complex	Human	None	HEK293 cells	P04198;Q96EB6	4613;;23411	MI:0019-coimmunoprecipitation	GO:0045892;GO:0005634	negative regulation of DNA-templated transcription;nucleus	11.02.03.04.03;70.10	transcription repression;nucleus	21698133	SIRT1 functions as an oncoprotein in N-Myc oncogenesis through forming a transcriptional repressor complex with N-Myc, repressing MKP3 gene transcription and consequently stabilizing N-Myc oncoprotein, and that SIRT1 inhibitors exert anticancer effects against N-Myc-induced neuroblastoma in vitro and in vivo.	The MYCN expression profile is one of the most robust and significant prognostic markers for neuroblastoma outcome. SIRT1 promotes MYCN oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on MYCN protein stability.	None	Homo sapiens (Human);Homo sapiens (Human)	N-myc proto-oncogene protein;NAD-dependent protein deacetylase sirtuin-1	MYCN;SIRT1	BHLHE37 NMYC;SIR2L1
8712	HDAC2-MYCN-SP1 complex	Human	None	BE(2)-C cells	P04198;P08047;Q92769	4613;;6667;3066	MI:0019-coimmunoprecipitation;MI:0402-chromatin immunoprecipitation assay	GO:0005634;GO:0045892	nucleus;negative regulation of DNA-templated transcription	70.10;11.02.03.04.03	nucleus;transcription repression	20697349	MYCN forms a protein complex along with HDAC2 and Sp1, and the protein complex represses CCGN2 gene transcription by binding the Sp1 containing region downstream of the transcription start site.	The MYCN expression profile is one of the most robust and significant prognostic markers for neuroblastoma outcome. Transcriptional upregulation of histone deacetylase 2 promotes Myc-induced oncogenic effects.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	N-myc proto-oncogene protein;Transcription factor Sp1;Histone deacetylase 2	MYCN;SP1;HDAC2	BHLHE37 NMYC;TSFP1;None
8713	HDAC1-MYCN-SP1 complex	Human	None	LAN-1 neuroblastoma cells	P04198;P08047;Q13547	4613;;6667;3065	MI:0019-coimmunoprecipitation;MI:0402-chromatin immunoprecipitation assay	GO:0005634;GO:0045892	nucleus;negative regulation of DNA-templated transcription	70.10;11.02.03.04.03	nucleus;transcription repression	18003922	MYCN acts as a transrepressor by recruiting the HDAC1 protein to an Sp1-binding site.	The MYCN expression profile is one of the most robust and significant prognostic markers for neuroblastoma outcome. Repression of TG2 (tissue transglutaminase) expression by MYCN is required for neuritic differentiation arrest in neuroblastoma cells.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	N-myc proto-oncogene protein;Transcription factor Sp1;Histone deacetylase 1	MYCN;SP1;HDAC1	BHLHE37 NMYC;TSFP1;RPD3L1
8714	DOCK8-MYD88-PTK2B complex	Human	DOCK8-MyD88-Pyk2 complex	HEK293T cells	Q14289;Q8NF50;Q99836	2185;81704;4615	MI:0007-anti tag coimmunoprecipitation	GO:0045087;GO:0002221;GO:0002224;GO:0002755;GO:0050871;GO:0034162	innate immune response;pattern recognition receptor signaling pathway;toll-like receptor signaling pathway;MyD88-dependent toll-like receptor signaling pathway;positive regulation of B cell activation;toll-like receptor 9 signaling pathway	36.25.16.01	innate immune response (invertebrates and vertebrates)	22581261	DOCK8 was found to mediate a novel MyD88 signaling pathway, which is essential for TLR9-driven B cell proliferation and immunoglobulin production. DOCK8 becomes more strongly associated with MyD88 and Pyk2 after stimulation with TLR9 ligand CpG. This indicates that ligation of TLR9 by CpG causes recruitment and stabilization of a preexisting MyD88-Pyk2-DOCK8 complex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Protein-tyrosine kinase 2-beta;Dedicator of cytokinesis protein 8;Myeloid differentiation primary response protein MyD88	PTK2B;DOCK8;MYD88	FAK2 PYK2 RAFTK;None;None
8715	IKBKE-MAVS complex	Human	MAVS-IKKepsilon complex	lung epithelial A549 cells	Q14164;Q7Z434	9641;57506	MI:0663-confocal microscopy	GO:0002221;GO:0045087;GO:0039529;GO:0051607;GO:0031966;GO:0043331;GO:0019048	pattern recognition receptor signaling pathway;innate immune response;RIG-I signaling pathway;defense response to virus;mitochondrial membrane;response to dsRNA;modulation by virus of host process	36.25.16.01	innate immune response (invertebrates and vertebrates)	16731946	Vesicular stomatitis virus infection of lung epithelial A549 cells induces the binding of IKKepsilon (IKBKE) to MAVS at the mitochondrial membrane. Hepatitis C virus NS3-4A protease specifically cleaves the MAVS-IKKepsilon complex from the mitochondria as part of its immune evasion strategy. (PMID:16731946)	None	None	Homo sapiens (Human);Homo sapiens (Human)	Inhibitor of nuclear factor kappa-B kinase subunit epsilon;Mitochondrial antiviral-signaling protein	IKBKE;MAVS	IKKE IKKI KIAA0151;IPS1,KIAA1271,VISA
8719	TBK1-TRAF6 complex	Human	None	HEK293T cells	Q9UHD2;Q9Y4K3	29110;7189	MI:0007-anti tag coimmunoprecipitation	GO:0002221;GO:0045087;GO:0039529;GO:0051607;GO:0019048	pattern recognition receptor signaling pathway;innate immune response;RIG-I signaling pathway;defense response to virus;modulation by virus of host process	36.25.16.01	innate immune response (invertebrates and vertebrates)	30530224	Zika virus NS5 protein interacts with TBK1 and leads to less TBK1 in complex with TRAF6. This indicates that NS5 antagonizes IFN production through inhibiting the activation of TBK1.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Serine/threonine-protein kinase TBK1;TNF receptor-associated factor 6	TBK1;TRAF6	NAK;RNF85
8720	ECSIT-TAK1-TRAF6 complex	Human	TAK1-ECSIT-TRAF6 complex	THP1 cells, stimulated with LPS	O43318;Q9BQ95;Q9Y4K3	6885;51295;7189	MI:0071-molecular sieving	GO:0032496;GO:0034142;GO:0002221;GO:0045087;GO:0002224;GO:0051092;GO:0001819	response to lipopolysaccharide;toll-like receptor 4 signaling pathway;pattern recognition receptor signaling pathway;innate immune response;toll-like receptor signaling pathway;positive regulation of NF-kappaB transcription factor activity;positive regulation of cytokine production	36.25.16.01	innate immune response (invertebrates and vertebrates)	25371197	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mitogen-activated protein kinase kinase kinase 7;Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial;TNF receptor-associated factor 6	MAP3K7;ECSIT;TRAF6	TAK1;None;RNF85
8721	DDX3X-IKBKE complex	Human	DDX3-IKBKE complex; DDX3-IKKepsilon complex	HEK293 cells, stimulated with sendai virus or poly(I:C) transfection	O00571;Q14164	1654;9641	MI:0007-anti tag coimmunoprecipitation;MI:0096-pull down	GO:0032728;GO:0032481;GO:0045087;GO:0002221;GO:0039535;GO:0051607;GO:0019048	positive regulation of interferon-beta production;positive regulation of type I interferon production;innate immune response;pattern recognition receptor signaling pathway;regulation of RIG-I signaling pathway;defense response to virus;modulation by virus of host process	36.25.16.01	innate immune response (invertebrates and vertebrates)	18636090	SeV infection stimulates the binding of DDX3 to IKKepsilon and enhances TBK1-IKKepsilon-dependent  induction of the interferon-beta promoter. Vaccinia virus K7 protein interacts with DDX3 to prevent TBK1-IKKepsilon-mediated IRF3 activation.	None	None	Homo sapiens (Human);Homo sapiens (Human)	ATP-dependent RNA helicase DDX3X;Inhibitor of nuclear factor kappa-B kinase subunit epsilon	DDX3X;IKBKE	DBX DDX3;IKKE IKKI KIAA0151
8722	TIM23 subcomplex (TIMM17B, TIMM23, TIMM44), mitochondrial	Human	TIM (TIM17B, TIM23, TIM44) complex, mitochondrial	mitochondria from frozen HeLa cells; multiple human adult and fetal tissues	O14925;O43615;O60830	100287932;10469;10245	MI:0019-coimmunoprecipitation;MI:0047-far western blotting;MI:0071-molecular sieving	GO:0005743;GO:0005744;GO:0006839;GO:0005739;GO:0006626;GO:0071806;GO:0015031	mitochondrial inner membrane;TIM23 mitochondrial import inner membrane translocase complex;mitochondrial transport;mitochondrion;protein targeting to mitochondrion;protein transmembrane transport;protein transport	70.16.05;20.09.04;70.16;20.01.10	mitochondrial inner membrane;mitochondrial transport;mitochondrion;protein transport	10339406	Translocation of nuclear-encoded mitochondrial preproteins is mediated by translocases in the outer (TOM) and inner (TIM) membranes.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mitochondrial import inner membrane translocase subunit Tim23;Mitochondrial import inner membrane translocase subunit TIM44;Mitochondrial import inner membrane translocase subunit Tim17-B	TIMM23;TIMM44;TIMM17B	TIM23;MIMT44, TIM44;TIM17B
8723	TIM23(sort) complex (ROMO1, TIMM17B, TIMM21, TIMM23, TIMM50), mitochondrial	Human	TIM23 subcomplex	HEK293T cell line	O14925;O60830;P60602;Q3ZCQ8;Q9BVV7	100287932;10245;140823;92609;29090	MI:0019-coimmunoprecipitation;MI:0069-mass spectrometry studies of complexes	GO:0005743;GO:0005744;GO:0006839;GO:0005739;GO:0006626;GO:0015031	mitochondrial inner membrane;TIM23 mitochondrial import inner membrane translocase complex;mitochondrial transport;mitochondrion;protein targeting to mitochondrion;protein transport	70.16.05;20.09.04;70.16;20.01.10	mitochondrial inner membrane;mitochondrial transport;mitochondrion;protein transport	30598479	Expected subunits of the TIM23 complex such as TIM17A, TIM17B, and TIM44 with TIM23, TIM21, and TIM50 were identified. Additionally, in all analyses, a protein named ROMO1 (ROS modulator 1) was identified.	None	ROMO1 participates in coupling TIM21 to the TIM23 complex. Human TIM21 associates with the TIM23 complex but is dispensable for protein import. In addition, it is a constituent of the MITRAC complex, which represents an assembly intermediate of cytochrome c oxidase. ROMO1 as a translocase constituent with an exceptionally short half-life.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mitochondrial import inner membrane translocase subunit Tim23;Mitochondrial import inner membrane translocase subunit Tim17-B;Reactive oxygen species modulator 1;Mitochondrial import inner membrane translocase subunit TIM50;Mitochondrial import inner membrane translocase subunit Tim21	TIMM23;TIMM17B;ROMO1;TIMM50;TIMM21	TIM23;TIM17B;C20orf52;TIM50;C18orf55 TIM21
8724	IFNAR1-IFNAR2-RACK1-STAT1 complex	Human	IFN alpha receptor, type 1-RACK1-STAT1 complex; Interferon alpha receptor, type 1-RACK1-STAT1 complex	SiHa cells, infected wwith MeV strain AK-1	P17181;P42224;P48551;P63244	3454;6772;3455;10399	MI:0006-anti bait coimmunoprecipitation	GO:0060338;GO:0009615;GO:0051607;GO:0045087;GO:0002221;GO:0019221;GO:0046425;GO:0019048	regulation of type I interferon-mediated signaling pathway;response to virus;defense response to virus;innate immune response;pattern recognition receptor signaling pathway;cytokine-mediated signaling pathway;regulation of receptor signaling pathway via JAK-STAT;modulation by virus of host process	36.25.16.01	innate immune response (invertebrates and vertebrates)	12620806	Infection with measles virus (MeV)) leads to a tight complex between MeV proteins V and C and the IFNAR1-IFNAR2-RACK1-STAT1 complex. Consequently IFN-alpha signals are not transduced. (PMID:12620806)	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Interferon alpha/beta receptor 1;Signal transducer and activator of transcription 1-alpha/beta;Interferon alpha/beta receptor 2;Receptor of activated protein C kinase 1	IFNAR1;STAT1;IFNAR2;RACK1	IFNAR;None;IFNABR IFNARB;GNB2L1
8725	AZI2-TBK1 complex	Human	NAK-NAP1 complex; NAP1-TBK1 complex	HEK293T cells; HeLa cells	Q9H6S1;Q9UHD2	64343;29110	MI:0006-anti bait coimmunoprecipitation;MI:0004-affinity chromatography technology;MI:0007-anti tag coimmunoprecipitation	GO:0051092;GO:0034612;GO:0032608;GO:0002224;GO:0032496;GO:0034142	positive regulation of NF-kappaB transcription factor activity;response to tumor necrosis factor;interferon-beta production;toll-like receptor signaling pathway;response to lipopolysaccharide;toll-like receptor 4 signaling pathway	None	None	14560022	NAP1 enhances NAK-induced NF-kappaB activation. The NAK-NAP1 complex phosphorylates the p65/RelA subunit of NF-kappaB, and this activity is stimulated by TNF-alpha (PMID:14560022). In addition, this complex is also involved in the activation of the IFN-beta promoter (PMID:15611223).	None	None	Homo sapiens (Human);Homo sapiens (Human)	5-azacytidine-induced protein 2;Serine/threonine-protein kinase TBK1	AZI2;TBK1	NAP1 TBKBP2;NAK
8726	TNFR2-TRAF signaling complex	Human	BIRC2-TNFRSF1B-TRAF2-TRAF3 complex; c-IAP1-TNFR2-TRAF2-TRAF3 complex	HEK293 cells	P20333;Q12933;Q13114;Q13490	7133;7186;7187;329	MI:0007-anti tag coimmunoprecipitation	GO:0033209;GO:0050727	tumor necrosis factor-mediated signaling pathway;regulation of inflammatory response	None	None	8548810	The association of TNFR2 and c-IAPl was specifically mediated by the TRAF1-TRAF2 heterocomplex.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Tumor necrosis factor receptor superfamily member 1B;TNF receptor-associated factor 2;TNF receptor-associated factor 3;Baculoviral IAP repeat-containing protein 2	TNFRSF1B;TRAF2;TRAF3;BIRC2	TNFBR, TNFR2;TRAP3;CAP-1 CRAF1 TRAFAMN;API1 MIHB RNF48
8727	KCNE1-KCNQ1 complex	Human	None	HEK 293 cells	P15382;P51787	3753;3784	MI:0096-pull down;MI:0019-coimmunoprecipitation	GO:0005267;GO:0034705;GO:0071805;GO:0008076;GO:0005249	potassium channel activity;potassium channel complex;potassium ion transmembrane transport;voltage-gated potassium channel complex;voltage-gated potassium channel activity	None	None	19521339	\u2022 KCNQ1 and KCNE1 binding generates the IKS K+ current, which is important  for the cardiac action potential repolarization. KCNQ1 helix C interacts with the KCNE1 distal C-terminus.	Mutations in KCNE1 and KCNQ1 cause long QT syndrome (LQT) and atrial fibrillation. (PMID: 25037568)	None	Homo sapiens (Human);Homo sapiens (Human)	Potassium voltage-gated channel subfamily E member 1;Potassium voltage-gated channel subfamily KQT member 1	KCNE1;KCNQ1	None;KCNA8 KCNA9 KVLQT1
8729	IRF3-HSP90-TBK1 complex	Human	TBK1-Hsp90-IRF3 complex	HEK293 cells	Q14653;Q76LV2;Q9UHD2	3661;281832;29110	MI:0006-anti bait coimmunoprecipitation	GO:0009615;GO:0045087;GO:0002224;GO:0002221;GO:0051607;GO:0032481	response to virus;innate immune response;toll-like receptor signaling pathway;pattern recognition receptor signaling pathway;defense response to virus;positive regulation of type I interferon production	36.25.16.01	innate immune response (invertebrates and vertebrates)	16394098	Hsp90 forms a dynamic complex with IRF3 and TBK1. This complex is essential for IRF3 activation in response to Sendai virus. Hsp90 is important for stabilizing TBK1 and promoting IRF3 phosphorylation by TBK1 in response to virus infection.	None	Since the authors did not specify HSP90, we used isoform HSP90-alpha (HSP90AA1).	Homo sapiens (Human);Bos taurus (Bovine);Homo sapiens (Human)	Interferon regulatory factor 3;Heat shock protein HSP 90-alpha;Serine/threonine-protein kinase TBK1	IRF3;HSP90AA1;TBK1	None;HSP90A, HSPCA;NAK
8730	BAX-HSP90-IRF3-TOMM70 complex	Human	None	HEK293T cells	O94826;P07900;Q07812;Q14653	9868;3320;581;3661	MI:0019-coimmunoprecipitation;MI:0113-western blot	GO:0016032;GO:0005741;GO:0006915;GO:0140374	viral process;mitochondrial outer membrane;apoptotic process;antiviral innate immune response	70.16.01;40.10.02	mitochondrial outer membrane;apoptosis (type I programmed cell death)	25609812	It is demonstrated that IRF3 associates with Bax upon virus infection. Tom70 recruits this protein complex to the mitochondrial outer membrane through Hsp90, which thus induces the release of cytochrome c into the cytosol, initiating virus-induced apoptosis. The recent study characterized Tom70 as an important adaptor linking MAVS to TBK1/IRF3 activation, thus establishing a novel function of Tom70 in innate immunity.	None	Since the authors did not specify HSP90, we used HSP90AA1.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mitochondrial import receptor subunit TOM70;Heat shock protein HSP 90-alpha;Apoptosis regulator BAX;Interferon regulatory factor 3	TOMM70;HSP90AA1;BAX;IRF3	KIAA0719 TOM70 TOMM70A;HSP90A HSPC1 HSPCA;BCL2L4;None
8731	BAX-IRF3 complex	Human	None	HEK293T cells	Q07812;Q14653	581;3661	MI:0019-coimmunoprecipitation	GO:0016032;GO:0045087;GO:0006915	viral process;innate immune response;apoptotic process	36.25.16.01;40.10.02	innate immune response (invertebrates and vertebrates);apoptosis (type I programmed cell death)	25609812	It is demonstrated that IRF3 associates with Bax upon virus infection. Tom70 recruits this protein complex to the mitochondrial outer membrane through Hsp90, which thus induces the release of cytochrome c into the cytosol, initiating virus-induced apoptosis.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Apoptosis regulator BAX;Interferon regulatory factor 3	BAX;IRF3	BCL2L4;None
8732	HSP90-RIG-I complex	Human	None	HT-29 cells	O95786;P07900	23586;3320	MI:0006-anti bait coimmunoprecipitation	GO:0002221;GO:0045087;GO:0039535;GO:0032481;GO:0032728	pattern recognition receptor signaling pathway;innate immune response;regulation of RIG-I signaling pathway;positive regulation of type I interferon production;positive regulation of interferon-beta production	36.25.16.01	innate immune response (invertebrates and vertebrates)	19234166	HSP90-alpha interacts with RIG-I and inhibition of this interaction leads to ubiquitination and proteasomal degradation of RIG-I. This indicates that the chaperone activity of HSP90 stabilizes RIG-I and protects RIG-I from proteolytic degradation.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Antiviral innate immune response receptor RIG-I;Heat shock protein HSP 90-alpha	DDX58;HSP90AA1	None;HSP90A HSPC1 HSPCA
8733	IRAK2-MAL complex	Human	MAL-IRAK2 complex	HEK293T cells	O43187;P21145	3656;4118;	MI:0006-anti bait coimmunoprecipitation	GO:0051607;GO:0019048;GO:0034143;GO:0002221;GO:0045087;GO:0051092	defense response to virus;modulation by virus of host process;regulation of toll-like receptor 4 signaling pathway;pattern recognition receptor signaling pathway;innate immune response;positive regulation of NF-kappaB transcription factor activity	36.25.16.01	innate immune response (invertebrates and vertebrates)	12566418	The vaccinia virus protein A52R inhibits the activation of NF-kappaB by Mal by preventing the formation of an active Mal-IRAK2 signaling complex.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Interleukin-1 receptor-associated kinase-like 2;Myelin and lymphocyte protein	IRAK2;MAL	None;None
8734	HSP90-IRF3-MAVS-TBK1-TOMM70 complex	Human	None	HEK293T cells	O94826;P07900;Q14653;Q7Z434;Q9UHD2	9868;3320;3661;57506;29110	MI:0019-coimmunoprecipitation	GO:0005741;GO:0016032;GO:0006915;GO:0140374	mitochondrial outer membrane;viral process;apoptotic process;antiviral innate immune response	70.16.01;40.10.02	mitochondrial outer membrane;apoptosis (type I programmed cell death)	20628368	The translocase of the outer mitochondrial membrane 70 (Tom70), a mitochondrial import receptor, was identified to interact with MAVS upon RNA virus infection. Ectopic expression or knockdown of Tom70 could enhance or impair IRF3-mediated gene expression, respectively. A transient formation of a stable signal complex on the mitochondrial outer membrane, including MAVS/Tom70/Hsp90/TBK1/IRF3, could be found. It is suggested that Tom70 is a novel component of the MAVS signalosome. The current study sheds new light on the evolutionary integration of mitochondria with antiviral innate immunity.	None	Since the authors did not specify HSP90, we used HSP90AA1.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mitochondrial import receptor subunit TOM70;Heat shock protein HSP 90-alpha;Interferon regulatory factor 3;Mitochondrial antiviral-signaling protein;Serine/threonine-protein kinase TBK1	TOMM70;HSP90AA1;IRF3;MAVS;TBK1	KIAA0719 TOM70 TOMM70A;HSP90A HSPC1 HSPCA;None;IPS1,KIAA1271,VISA;NAK
8735	R2TP complex	Human	PIH1D1-RPAP3-RUVBL1-RUVBL2 complex	human genes expressed in pLysS cells	Q9H6T3;Q9NWS0;Q9Y230;Q9Y265	79657;55011;10856;8607	MI:0096-pull down;MI:0040-electron microscopy	GO:0097255;GO:0065003;GO:0006457;GO:0009615;GO:0045069;GO:0019048	R2TP complex;protein-containing complex assembly;protein folding;response to virus;regulation of viral genome replication;modulation by virus of host process	14.01	protein folding and stabilization	29662061	R2TP complex functions with Hsp90 to facilitate assembly of protein complexes (PMID:31121004). In addition, the R2TP complex is a host factor that interacts with the mumps virus (MuV) L protein to regulate MuV RNA synthesis. This regulation is critical for MuV evasion of host innate immune responses to ensure its replication. (PMID:31121004)	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	RNA polymerase II-associated protein 3;PIH1 domain-containing protein 1;RuvB-like 2;RuvB-like 1	RPAP3;PIH1D1;RUVBL2;RUVBL1	None;NOP17;INO80J TIP48 TIP49B;INO80H NMP238 TIP49 TIP49A
8736	MAVS-TOMM70 complex	Human	None	HEK293T cells	O94826;Q7Z434	9868;57506	MI:0019-coimmunoprecipitation;MI:0113-western blot	GO:0140374;GO:0005741;GO:0016032	antiviral innate immune response;mitochondrial outer membrane;viral process	70.16.01	mitochondrial outer membrane	20628368	Tom70 is found to interact specifically with MAVS during RNA virus infection. Tom70 plays an essential role in the antiviral response.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Mitochondrial import receptor subunit TOM70;Mitochondrial antiviral-signaling protein	TOMM70;MAVS	KIAA0719 TOM70 TOMM70A;IPS1,KIAA1271,VISA
8737	EFNB1-TUBB4B complex	Human	None	HSC-3 cells, SAS cells	P68371;P98172	10383;;1947	MI:0019-coimmunoprecipitation	GO:0072657	protein localization to membrane	None	None	35004310	None	Cancer stem cell (CSC) niche is a crucial factor modulating tumor progression and treatment outcomes. TUBB4B was found to be overexpressed in the membranes of stem cell enriched cultures. TUBB4B and Ephrin-B1 cohabit in the CSC niche. Ephrin-B1 is a signaling protein, the abrogation of which reduces the self-renewal of oral cancer stem cells. TUBB4B regulates the membrane localization of Ephrin-B1.	None	Homo sapiens (Human);Homo sapiens (Human)	Tubulin beta-4B chain;Ephrin-B1	TUBB4B;EFNB1	TUBB2C;EFL3 EPLG2 LERK2
8739	HSP90-TOMM70 complex	Human	HSP90-TOM70 complex	HEK293T cells	O94826;P07900	9868;3320	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0005741;GO:0016032;GO:0140374;GO:0002221;GO:0045087;GO:0051607;GO:0032481;GO:0019048	mitochondrial outer membrane;viral process;antiviral innate immune response;pattern recognition receptor signaling pathway;innate immune response;defense response to virus;positive regulation of type I interferon production;modulation by virus of host process	70.16.01;36.25.16.01	mitochondrial outer membrane;innate immune response (invertebrates and vertebrates)	20628368	Tom70 modulates IRF3-mediated antiviral responses. The direct interaction between Tom70 and Hsp90 is essential for IRF3 activation. The clamp domain (R192) of Tom70 interacts with the C-terminal motif (EEVD) of Hsp90, thus recruiting TBK1/IRF3 to mitochondria. Disruption of this interaction or mislocation of Tom70 sharply impairs activation of TBK1 and IRF3. Host antiviral responses are significantly boosted or crippled in the presence or absence of Tom70 (PMID:20628368). The interaction of TOM70 with HSP90 is essential for the induction of the antiviral interferon pathway. SARS-CoV-2 ORF9b protein binds TOM70 and forms a stable complex that prevents the interaction of TOM70 with Hsp90. This explains how SARS-CoV-2 can evade host immunity through the downregulation of IFN production in the host cell. (PMID:35643212)	None	Since the authors did not specify HSP90, we used HSP90AA1.	Homo sapiens (Human);Homo sapiens (Human)	Mitochondrial import receptor subunit TOM70;Heat shock protein HSP 90-alpha	TOMM70;HSP90AA1	KIAA0719 TOM70 TOMM70A;HSP90A HSPC1 HSPCA
8740	HSP90-IRF3-TBK1 complex	Human	None	HEK293T cells	P07900;Q14653;Q9UHD2	3320;3661;29110	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0140374;GO:0005741;GO:0016032	antiviral innate immune response;mitochondrial outer membrane;viral process	70.16.01	mitochondrial outer membrane	20628368	Tom70 recruits Hsp90/TBK1/IRF3 complex to mitochondria during viral infection.	None	Since the authors did not specify HSP90, we used HSP90AA1.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Heat shock protein HSP 90-alpha;Interferon regulatory factor 3;Serine/threonine-protein kinase TBK1	HSP90AA1;IRF3;TBK1	HSP90A HSPC1 HSPCA;None;NAK
8741	HSP90-IRF3-TBK1-TOMM70 complex	Human	None	HEK293T cells	O94826;P07900;Q14653;Q9UHD2	9868;3320;3661;29110	MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0140374;GO:0005741;GO:0016032	antiviral innate immune response;mitochondrial outer membrane;viral process	70.16.01	mitochondrial outer membrane	20628368	Tom70 recruits Hsp90/TBK1/IRF3 complex to mitochondria during viral infection. The translocase of the outer mitochondrial membrane 70 (Tom70), a mitochondrial import receptor, was identified to interact with MAVS upon RNA virus infection. Ectopic expression or knockdown of Tom70 could enhance or impair IRF3-mediated gene expression, respectively. A transient formation of a stable signal complex on the mitochondrial outer membrane, including MAVS/Tom70/Hsp90/TBK1/IRF3, could be found. It is suggested that Tom70 is a novel component of the MAVS signalosome. The current study sheds new light on the evolutionary integration of mitochondria with antiviral innate immunity.	None	Since the authors did not specify HSP90, we used HSP90AA1.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mitochondrial import receptor subunit TOM70;Heat shock protein HSP 90-alpha;Interferon regulatory factor 3;Serine/threonine-protein kinase TBK1	TOMM70;HSP90AA1;IRF3;TBK1	KIAA0719 TOM70 TOMM70A;HSP90A HSPC1 HSPCA;None;NAK
8742	CHUK-HSP90-IKBKB-TOMM70 complex	Human	HSP90-IKKA-IKKB-TOMM70 complex	HEK293T cells	O14920;O15111;O94826;P07900	3551;1147;9868;3320	MI:0019-coimmunoprecipitation	GO:0140374;GO:0005741;GO:0016032	antiviral innate immune response;mitochondrial outer membrane;viral process	70.16.01	mitochondrial outer membrane	20628368	It was found that Tom70 could immunoprecipitate IKK complex in the presence of Hsp90. Hsp90 binds strongly to and delivers IKK complex to Tom70, thus resulting in the activation of IKK and NF-kappaB.	None	Since the authors did not specify HSP90, we used HSP90AA1.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Inhibitor of nuclear factor kappa-B kinase subunit beta;Inhibitor of nuclear factor kappa-B kinase subunit alpha;Mitochondrial import receptor subunit TOM70;Heat shock protein HSP 90-alpha	IKBKB;CHUK;TOMM70;HSP90AA1	IKKB;IKKA TCF16;KIAA0719 TOM70 TOMM70A;HSP90A HSPC1 HSPCA
8743	PEX3-PEX19 complex	Human	None	immortalized WT human skin fibroblast cell line (GM5756-TI);  PEX19-deficient cell line (PBD39)	P40855;P56589	5824;;8504	MI:0416-fluorescence microscopy	GO:0036105;GO:0005778;GO:0005737	peroxisome membrane class-1 targeting sequence binding;peroxisomal membrane;cytoplasm	70.03	cytoplasm	15007061	PEX19 is a chaperone and import receptor for newly synthesized, class I peroxisomal membrane proteins (PMPs). PEX19 binds these PMPs in the cytoplasm and delivers them to the peroxisome for subsequent insertion into the peroxisome membrane. PEX3 is required for PEX19 to dock at peroxisomes, interacts specifically with the docking domain of PEX19, and is required for recruitment of the PEX19 docking domain to peroxisomes. PEX3 is also sufficient to dock PEX19 at heterologous organelles and binds PEX19 via a conserved motif that is essential for this docking activity and for PEX3 function in general. PEX3 and PEX19 interact primarily at the surface of the peroxisome membrane.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Peroxisomal biogenesis factor 19;Peroxisomal biogenesis factor 3	PEX19;PEX3	HK33 PXF;None
8749	TRMT10A-FTO complex	Human	None	HEK293T cells	Q8TBZ6;Q9C0B1	93587;;79068;	MI:0019-coimmunoprecipitation;MI:0030-cross-linking study	GO:0030488;GO:0035552	tRNA methylation;oxidative single-stranded DNA demethylation	None	None	32213595	A tRNA methyltransferase, TRMT10A, interacts with an mRNA demethylase FTO (ALKBH9), both in vitro and inside cells. TRMT10A installs N 1-methylguanosine (m1G) in tRNA, and FTO performs demethylation on N 6-methyladenosine (m6A) and N 6,2'-O-dimethyladenosine (m6Am) in mRNA.This complex has a dual role: methylation of the ninth G on several tRNAs and demethylation of certain mRNAs through FTO. TRMT10A:FTO target mRNAs appeared to be enriched with codons corresponding to likely tRNA targets of TRMT10A. (PMID:33683402)	None	None	Homo sapiens (Human);Homo sapiens (Human)	tRNA methyltransferase 10 homolog A;Alpha-ketoglutarate-dependent dioxygenase FTO	TRMT10A;FTO	RG9MTD2;KIAA1752
8750	MICU1-USP2 complex	Human	None	HeLa cells	P55851;Q9BPX6	7351;;10367	MI:0019-coimmunoprecipitation	GO:0006851	mitochondrial calcium ion transmembrane transport	None	None	27642082	None	None	None	Homo sapiens (Human);Homo sapiens (Human)	Mitochondrial uncoupling protein 2;Calcium uptake protein 1, mitochondrial	UCP2;MICU1	SLC25A8;CALC, CBARA1
8756	HEPH-SLC40A1 complex	Human	None	HEK293 cell	Q9BQS7;Q9NP59	9843;;None	MI:0055-fluorescent resonance energy transfer	GO:0034755	iron ion transmembrane transport	None	None	30647129	It was demonstrated that Fpn and Heph co-localize, and FRET analysis indicated that the two proteins form an iron-efflux complex.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Hephaestin;Solute carrier family 40 member 1	HEPH;SLC40A1	KIAA0698;FPN1 IREG1 SLC11A3
8757	MYCN-SP1-ZBTB17 complex	Human	MIZ1-MYCN-SP1 complex	HEK293 cells; SK-N-BE cells	P04198;P08047;Q13105	4613;;6667;None	MI:0019-coimmunoprecipitation;MI:0402-chromatin immunoprecipitation assay	GO:0045892;GO:0005634	negative regulation of DNA-templated transcription;nucleus	11.02.03.04.03;70.10	transcription repression;nucleus	21123453	The MYCN-SP1-ZBTB17 complex performs transcriptional repression of TRKA and p75NTR, two neurotrophin receptors.	The MYCN-SP1-ZBTB17 complex affects neuroblastoma malignancy by inhibiting the cell response to NGF.	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	N-myc proto-oncogene protein;Transcription factor Sp1;Zinc finger and BTB domain-containing protein 17	MYCN;SP1;ZBTB17	BHLHE37 NMYC;TSFP1;MIZ1 ZNF151 ZNF60
8758	AURKA-MYCN complex	Human	None	SH-EP cells	O14965;P04198	6790;4613;	MI:0019-coimmunoprecipitation	GO:0006626;GO:0005634	protein targeting to mitochondrion;nucleus	70.10	nucleus	19111882	None	In human neuroblastoma, amplification of the MYCN gene predicts poor prognosis and resistance to therapy. Aurora A is a protein that binds to and stabilizes N-Myc.	None	Homo sapiens (Human);Homo sapiens (Human)	Aurora kinase A;N-myc proto-oncogene protein	AURKA;MYCN	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6;BHLHE37 NMYC
8759	KDM1A-MYCN complex	Human	None	Tet-21/N cells	O60341;P04198	23028;4613;	MI:0019-coimmunoprecipitation	GO:0006355	regulation of DNA-templated transcription	11.02.03.04	transcriptional control	26062444	MYCN interacts with KDM1A (LSD1), a monoamine oxidase that function as master epigenetic regulator in neuroblastoma cell lines. The KDM1A-MYCN complex is involved either in activation or repression of MYCN target genes in neuroblastoma cell lines (PMID:27894074).	Neuroblastoma with MYCN amplification is a highly aggressive and metastatic tumor in children.	None	Homo sapiens (Human);Homo sapiens (Human)	Lysine-specific histone demethylase 1A;N-myc proto-oncogene protein	KDM1A;MYCN	AOF2 KDM1 KIAA0601 LSD1;BHLHE37 NMYC
8760	MAP2K1-WWOX complex	Human	MEK1-WWOX complex	Jurkat cells	Q02750;Q9NZC7	5604;51741	MI:0019-coimmunoprecipitation;MI:0018-two hybrid	GO:0012501;GO:0005764	programmed cell death;lysosome	40.10.90;70.25	other programmed cell death;vacuole or lysosome	21901168	The MAP2K1-WWOX complex is a master on/off switch for apoptosis in leukemia T cells.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Dual specificity mitogen-activated protein kinase kinase 1;WW domain-containing oxidoreductase	MAP2K1;WWOX	MEK1 PRKMK1;FOR SDR41C1 WOX1
8761	HYAL2-WWOX complex	Human	None	THP-1 cells	Q12891;Q9NZC7	8692;;51741	MI:0019-coimmunoprecipitation	GO:0005634;GO:0008219	nucleus;cell death	70.10;40.10	nucleus;cell death	27845895	In traumatic brain injury-induced neuronal death, the HYAL2-WWOX complex was accumulated in the apoptotic nuclei of neurons in the rat brains in 24 hr post injury.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Hyaluronidase-2;WW domain-containing oxidoreductase	HYAL2;WWOX	LUCA2;FOR SDR41C1 WOX1
8762	HYAL2-SMAD3-WWOX complex	Human	None	SK-N-SH cells	P84022;Q12891;Q9NZC7	4088;8692;;51741	MI:0019-coimmunoprecipitation	None	None	None	None	27845895	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Mothers against decapentaplegic homolog 3;Hyaluronidase-2;WW domain-containing oxidoreductase	SMAD3;HYAL2;WWOX	MADH3;LUCA2;FOR SDR41C1 WOX1
8763	HYAL2-SMAD4-WWOX complex	Human	None	U937 cells	Q12891;Q13485;Q9NZC7	8692;;4089;51741	MI:0019-coimmunoprecipitation;MI:0018-two hybrid	GO:0008219;GO:0045893;GO:0005634	cell death;positive regulation of DNA-templated transcription;nucleus	40.10;11.02.03.04.01;70.10	cell death;transcription activation;nucleus	27845895	In a non-canonical signaling, TGF-beta binds membrane hyaluronidase Hyal-2 for recruiting tumor suppressors WWOX and SMAD4, and the resulting HYAL2-SMAD4-WWOX complex is accumulated in the nucleus to enhance SMAD-promoter dependent transcriptional activity.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Hyaluronidase-2;Mothers against decapentaplegic homolog 4;WW domain-containing oxidoreductase	HYAL2;SMAD4;WWOX	LUCA2;DPC4 MADH4;FOR SDR41C1 WOX1
8764	SMAD4-TP53-WWOX complex	Human	None	DU145 cells	P04637;Q13485;Q9NZC7	7157;4089;51741	MI:0055-fluorescent resonance energy transfer	None	None	None	None	27845895	Hyaluronan induces the signaling pathways for the SMAD4-TP53-WWOX complex, which causes membrane blebbing but without cell death.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Cellular tumor antigen p53;Mothers against decapentaplegic homolog 4;WW domain-containing oxidoreductase	TP53;SMAD4;WWOX	P53;DPC4 MADH4;FOR SDR41C1 WOX1
8765	mSin3A corepressor complex	Human	None	HeLa nuclear extract	O00422;O75446;Q09028;Q13547;Q16576;Q92769;Q96ST3	10284;8819;5928;3065;5931;3066;25942	MI:0004-affinity chromatography technology	GO:0051276;GO:0003677;GO:0006265;GO:0045892;GO:0005634;GO:0016575	chromosome organization;DNA binding;DNA topological change;negative regulation of DNA-templated transcription;nucleus;histone deacetylation	42.10.03;16.03.01;10.01.09.05;11.02.03.04.03;70.10	organization of chromosome structure;DNA binding;DNA conformation modification (e.g. chromatin);transcription repression;nucleus	9150135	None	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Histone deacetylase complex subunit SAP18;Histone deacetylase complex subunit SAP30;Histone-binding protein RBBP4;Histone deacetylase 1;Histone-binding protein RBBP7;Histone deacetylase 2;Paired amphipathic helix protein Sin3a	SAP18;SAP30;RBBP4;HDAC1;RBBP7;HDAC2;SIN3A	None;None;RBAP48;RPD3L1;RBAP46;None;None
8766	NFKB1-RELA-UXT complex	Human	NF-kappaB-UXT complex	HEK293T cells	P19838;Q04206;Q9UBK9	4790;5970;8409;	MI:0019-coimmunoprecipitation;MI:0412-electrophoretic mobility supershift assay	GO:0005634;GO:0006355;GO:0006915	nucleus;regulation of DNA-templated transcription;apoptotic process	70.10;11.02.03.04;40.10.02	nucleus;transcriptional control;apoptosis (type I programmed cell death)	17620405	UXT forms a signal-dependent complex with NF-kappaB and is recruited to the NF-kappaB enhanceosome upon stimulation.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Nuclear factor NF-kappa-B p105 subunit;Transcription factor p65;Protein UXT	NFKB1;RELA;UXT	None;NFKB3;None
8767	BCLAF1-TET2 complex	Human	None	SW620 cells	Q6N021;Q9NYF8	54790;;9774;	MI:0007-anti tag coimmunoprecipitation;MI:0416-fluorescence microscopy;MI:0813-proximity ligation assay	GO:0005634;GO:0044030;GO:0006355	nucleus;regulation of DNA methylation;regulation of DNA-templated transcription	70.10;11.02.03.04	nucleus;transcriptional control	35660018	None	BCLAF1-TET2 transcription repression complex epigenetically regulates the expression of colorectal cancer gene ASCL2 via methylation of its promoter.	None	Homo sapiens (Human);Homo sapiens (Human)	Methylcytosine dioxygenase TET2;Bcl-2-associated transcription factor 1	TET2;BCLAF1	KIAA1546;BTF KIAA0164
8768	TNNC1-TNNI3-TNNT2 complex	Human	cardiac troponin complex	in vitro	P19429;P45379;P63316	7137;;7139;;7134;	MI:0226-ion exchange chromatography;MI:0071-molecular sieving	GO:0060047	heart contraction	None	None	11162386	Cardiac troponin (cTn), a phosphoprotein complex, consists of the tropomyosin binding subunit (cTnT), the inhibitory subunit (cTnI) and the calcium binding subunit (cTnC) and is the major regulatory protein complex of thin filaments.	None	None	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Troponin I, cardiac muscle;Troponin T, cardiac muscle;Troponin C, slow skeletal and cardiac muscles	TNNI3;TNNT2;TNNC1	TNNC1;None;TNNC
8771	CRLF2-Il7R-TSLP complex	Human	Il7R-TSLP-TSLPR complex	HEK293 cells	P16871;Q969D9;Q9HC73	3575;85480;;64109;	MI:0114-x-ray crystallography	GO:0006954;GO:0007259	inflammatory response;receptor signaling pathway via JAK-STAT	36.25.16.07;30.01.05.01.01	inflammatory response;JAK-STAT cascade	28368013	TSLP is a central orchestrator of type 2 helper T cell (Th2) responses that initiate allergy and inflammation.	Formation of the ternary complex activates JAK1/2, which, through downstream pathways , induces the expression of Th2 cytokines including IL-4, IL-5, IL-9, and IL-13.	The assembly of the ternary complex is stepwise, as TSLP does not interact appreciably with Il7R until after it has bound TSLPR.	Homo sapiens (Human);Homo sapiens (Human);Homo sapiens (Human)	Interleukin-7 receptor subunit alpha;Thymic stromal lymphopoietin;Cytokine receptor-like factor 2	IL7R;TSLP;CRLF2	None;None;CRL2 ILXR TSLPR
8772	CLEC4M-VWF complex	Human	None	HEK293 cells	P04275;Q9H2X3	7450;10332;	MI:0416-fluorescence microscopy;MI:0411-enzyme linked immunosorbent assay	GO:0006897	endocytosis	20.09.18.09.01	endocytosis	23529928	von Willebrand factor (VWF) is a plasma glycoprotein that mediates platelet adhesion and aggregation and acts as the carrier protein for factor VIII (FVIII). CLEC4M functions as a VWF clearance receptor by binding VWF and facilitating its internalization and targeting to early endosomes.	None	None	Homo sapiens (Human);Homo sapiens (Human)	von Willebrand factor;C-type lectin domain family 4 member M	VWF;CLEC4M	F8VWF;CD209L CD209L1 CD299
8773	F8-VWF complex	Human	None	blood plasma	P00451;P04275	2157;;7450	MI:0071-molecular sieving;MI:0892-solid phase assay	GO:0007596;GO:1900046	blood coagulation;regulation of hemostasis	36.25.16.09	blood coagulation	7756647	In plasma, factor 8 is bound to von Willebrand factor (VWF), a glycoprotein that plays an essential role in hemostasis by promoting the attachment of platelets to the injured vessel wall. Complex formation was shown to protect factor 8 against inactivation by activated protein C, and activation and inactivation by factor 10a.	A deficiency of factor 8 results in hemophilia A, a bleeding disorder affecting 1 in 10,000 males.	None	Homo sapiens (Human);Homo sapiens (Human)	Coagulation factor VIII;von Willebrand factor	F8;VWF	F8C;F8VWF
8774	SNX1A-SNX2 complex	Human	None	human SNX expressed in COS7 cells	O60749-1;Q13596-2	6643;6642	MI:0019-coimmunoprecipitation	GO:0015031	protein transport	20.01.10	protein transport	9819414	SNX2 forms heteromeric complexes with SNX1, SNX1A, and SNX4 but not with SNX3.	None	SNX1A (457 aa) is a splice variant/isoform of SNX1 (522 aa); SNX2 (519 aa) = splice variant/isoform;	Homo sapiens (Human);Homo sapiens (Human)	Isoform 1 of Sorting nexin-2;Isoform 1A of Sorting nexin-1	SNX2;SNX1	None;None
8775	SNX2-SNX4 complex	Human	None	human SNX expressed in COS7 cells	O60749-1;O95219-1	6643;8723	MI:0019-coimmunoprecipitation	GO:0015031	protein transport	20.01.10	protein transport	9819414	SNX2 forms heteromeric complexes with SNX1, SNX1A, and SNX4 but not with SNX3.	None	SNX2 (519 aa) and SNX4 (450 aa) are splice variants/isoforms;	Homo sapiens (Human);Homo sapiens (Human)	Isoform 1 of Sorting nexin-2;Isoform 1 of Sorting nexin-4	SNX2;SNX4	None;None
8776	LEPR-SNX1A complex	Human	LEPR-B - SNX1A complex; LEPR (long isoform) - SNX1A complex	human SNX expressed in COS7 cells	P48357-1;Q13596-2	None;6642	MI:0019-coimmunoprecipitation	GO:0038021;GO:1990460	leptin receptor activity;leptin receptor binding	None	None	9819414	SNX1, SNX1A, SNX2, and SNX4 coimmunoprecipitated with the long form of the leptin receptor, but not with the short and medium isoforms. SNX3 was not found to associate with any of the receptors studied.	None	SNX1A (457 aa) is a splice variant/isoform of SNX1 (522 aa); LEPR B is the long splice variant/isoform of LEPR:	Homo sapiens (Human);Homo sapiens (Human)	Isoform B of Leptin receptor;Isoform 1A of Sorting nexin-1	LEPR;SNX1	DB OBR;None
8777	LEPR-SNX2 complex	Human	LEPR-B - SNX2 complex; LEPR (long isoform) - SNX2 complex	human SNX expressed in COS7 cells	O60749-1;P48357-1	6643;None	MI:0019-coimmunoprecipitation	GO:0038021;GO:1990460	leptin receptor activity;leptin receptor binding	None	None	9819414	SNX1, SNX1A, SNX2, and SNX4 coimmunoprecipitated with the long form of the leptin receptor. Association between SNX3 and hLR303 was not detected.	None	SNX2 (519 aa) = splice variant/isoform; LEPR B is the long splice variant/isoform of LEPR;	Homo sapiens (Human);Homo sapiens (Human)	Isoform 1 of Sorting nexin-2;Isoform B of Leptin receptor	SNX2;LEPR	None;DB OBR
8778	LEPR-SNX4 complex	Human	LEPR-B - SNX4 complex; LEPR (long isoform) - SNX4 complex	human SNX expressed in COS7 cells	O95219-1;P48357	8723;3953	MI:0019-coimmunoprecipitation	GO:0038021;GO:1990460	leptin receptor activity;leptin receptor binding	None	None	9819414	SNX1, SNX1A, SNX2, and SNX4 coimmunoprecipitated with the long form of the leptin receptor, but not with the short and medium isoforms. SNX3 was not found to associate with any of the receptors studied.	None	SNX4 (450 aa) = splice variant/isoform; LEPR B is the long splice variant/isoform of LEPR;	Homo sapiens (Human);Homo sapiens (Human)	Isoform 1 of Sorting nexin-4;Leptin receptor	SNX4;LEPR	None;DB, OBR
8779	INSR-SNX1A complex	Human	None	human SNX expressed in COS7 cells	P06213;Q13596-2	3643;6642	MI:0019-coimmunoprecipitation;MI:0113-western blot	GO:0005158;GO:0008286	insulin receptor binding;insulin receptor signaling pathway	30.05.01.12.05	insulin receptor signalling pathway	9819414	After incubation of cell extracts with an insulin receptor beta-subunit antibody followed by Western blotting of the precipitates with antibody to the epitope tag, it was found that SNX1, SNX1A, and SNX2 and small amounts of SNX4 coimmunoprecipitated with the insulin receptor.	None	SNX1A = splice variant/isoform of SNX1;	Homo sapiens (Human);Homo sapiens (Human)	Insulin receptor;Isoform 1A of Sorting nexin-1	INSR;SNX1	None;None
8780	INSR-SNX2 complex	Human	None	human SNX expressed in COS7 cells	O60749-1;P06213	6643;3643	MI:0019-coimmunoprecipitation;MI:0113-western blot	GO:0005158;GO:0008286	insulin receptor binding;insulin receptor signaling pathway	30.05.01.12.05	insulin receptor signalling pathway	9819414	After incubation of cell extracts with an insulin receptor beta-subunit antibody followed by Western blotting of the precipitates with antibody to the epitope tag, it was found that SNX1, SNX1A, and SNX2 and small amounts of SNX4 coimmunoprecipitated with the insulin receptor.	None	SNX2 = splice variant/isoform;	Homo sapiens (Human);Homo sapiens (Human)	Isoform 1 of Sorting nexin-2;Insulin receptor	SNX2;INSR	None;None
8781	INSR-SNX4 complex	Human	None	human SNX expressed in COS7 cells	O95219-1;P06213	8723;3643	MI:0019-coimmunoprecipitation;MI:0113-western blot	GO:0005158;GO:0008286	insulin receptor binding;insulin receptor signaling pathway	30.05.01.12.05	insulin receptor signalling pathway	9819414	After incubation of cell extracts with an insulin receptor beta-subunit antibody followed by Western blotting of the precipitates with antibody to the epitope tag, it was found that SNX1, SNX1A, and SNX2 and small amounts of SNX4 coimmunoprecipitated with the insulin receptor.	None	SNX4= splice variant/isoform;	Homo sapiens (Human);Homo sapiens (Human)	Isoform 1 of Sorting nexin-4;Insulin receptor	SNX4;INSR	None;None
8782	SNX1A-TFRC complex	Human	None	human SNX expressed in COS7 cells	P02786;Q13596-2	7037;6642	MI:0019-coimmunoprecipitation;MI:0113-western blot	GO:0004998;GO:1990459	transferrin receptor activity;transferrin receptor binding	None	None	9819414	Only SNX1 and SNX1A coimmunoprecipitated with endogenous transferrin receptors. Association between endogenous transferrin receptors and SNX2, SNX3, or SNX4 were not detected.	None	SNX1A (457 aa) is a splice variant/isoform of SNX1 (522 aa);	Homo sapiens (Human);Homo sapiens (Human)	Transferrin receptor protein 1;Isoform 1A of Sorting nexin-1	TFRC;SNX1	None;None
8783	EGFR-SNX1A complex	Human	None	human SNX expressed in COS7 cells	P00533;Q13596-2	1956;6642	MI:0019-coimmunoprecipitation;MI:0113-western blot	GO:0005154;GO:0007173	epidermal growth factor receptor binding;epidermal growth factor receptor signaling pathway	30.05.01.12.01	EGF-receptor signalling pathway	9819414	In extracts from cells overexpressing EGF receptors and the various sorting nexins, it was found that SNX1 and SNX1A were readily detected in EGF receptor immunoprecipitates. SNX2 and SNX4 were detected, but to a lesser degree, and SNX3 was undetectable.	None	SNX1A is a splice variant/isoform of SNX1;	Homo sapiens (Human);Homo sapiens (Human)	Epidermal growth factor receptor;Isoform 1A of Sorting nexin-1	EGFR;SNX1	ERBB ERBB1 HER1;None
8784	EGFR-SNX2 complex	Human	None	human SNX expressed in COS7 cells	O60749-1;P00533	6643;1956	MI:0019-coimmunoprecipitation;MI:0113-western blot	GO:0005154;GO:0007173	epidermal growth factor receptor binding;epidermal growth factor receptor signaling pathway	30.05.01.12.01	EGF-receptor signalling pathway	9819414	In extracts from cells overexpressing EGF receptors and the various sorting nexins, it was found that SNX1 and SNX1A were readily detected in EGF receptor immunoprecipitates. SNX2 and SNX4 were detected, but to a lesser degree, and SNX3 was undetectable.	None	SNX2 = splice variant/isoform;	Homo sapiens (Human);Homo sapiens (Human)	Isoform 1 of Sorting nexin-2;Epidermal growth factor receptor	SNX2;EGFR	None;ERBB ERBB1 HER1
8785	EGFR-SNX4 complex	Human	None	human SNX expressed in COS7 cells	O95219-1;P00533	8723;1956	MI:0019-coimmunoprecipitation;MI:0113-western blot	GO:0005154;GO:0007173	epidermal growth factor receptor binding;epidermal growth factor receptor signaling pathway	30.05.01.12.01	EGF-receptor signalling pathway	9819414	In extracts from cells overexpressing EGF receptors and the various sorting nexins, it was found that SNX1 and SNX1A were readily detected in EGF receptor immunoprecipitates. SNX2 and SNX4 were detected, but to a lesser degree, and SNX3 was undetectable.	None	SNX4 = splice variant/isoform;	Homo sapiens (Human);Homo sapiens (Human)	Isoform 1 of Sorting nexin-4;Epidermal growth factor receptor	SNX4;EGFR	None;ERBB ERBB1 HER1
8786	PDGFRB-SNX1A complex	Human	None	human SNX expressed in COS7 cells	P09619;Q13596-2	5159;6642	MI:0019-coimmunoprecipitation;MI:0113-western blot	GO:0005161;GO:0005017	platelet-derived growth factor receptor binding;platelet-derived growth factor receptor activity	None	None	9819414	SNX1, SNX1A, and SNX2 were readily coimmunoprecipitated with PDGF receptors (beta isoform), while SNX4 was coimmunoprecipitated to a lesser extent. As with the insulin receptor and EGF receptor, no association was detectable between the PDGF receptor and SNX3.	None	SNX1A is splice variant/isoform of SNX1;	Homo sapiens (Human);Homo sapiens (Human)	Platelet-derived growth factor receptor beta;Isoform 1A of Sorting nexin-1	PDGFRB;SNX1	PDGFR PDGFR1;None
8787	PDGFRB-SNX2 complex	Human	None	human SNX expressed in COS7 cells	O60749-1;P09619	6643;5159	MI:0019-coimmunoprecipitation	GO:0005017;GO:0005161	platelet-derived growth factor receptor activity;platelet-derived growth factor receptor binding	None	None	9819414	SNX1, SNX1A, and SNX2 were readily coimmunoprecipitated with PDGF receptors (beta isoform), while SNX4 was coimmunoprecipitated to a lesser extent. As with the insulin receptor and EGF receptor, no association was detectable between the PDGF receptor and SNX3.	None	SNX2 = splice variant/isoform;	Homo sapiens (Human);Homo sapiens (Human)	Isoform 1 of Sorting nexin-2;Platelet-derived growth factor receptor beta	SNX2;PDGFRB	None;PDGFR PDGFR1
8788	PDGFRB-SNX4 complex	Human	None	human SNX expressed in COS7 cells	O95219-1;P09619	8723;5159	MI:0019-coimmunoprecipitation;MI:0113-western blot	GO:0005017;GO:0005161	platelet-derived growth factor receptor activity;platelet-derived growth factor receptor binding	None	None	9819414	SNX1, SNX1A, and SNX2 were readily coimmunoprecipitated with PDGF receptors (beta isoform), while SNX4 was coimmunoprecipitated to a lesser extent. As with the insulin receptor and EGF receptor, no association was detectable between the PDGF receptor and SNX3.	None	SNX4 = splice variant/isoform;	Homo sapiens (Human);Homo sapiens (Human)	Isoform 1 of Sorting nexin-4;Platelet-derived growth factor receptor beta	SNX4;PDGFRB	None;PDGFR PDGFR1
8791	PEX5-PEX12 complex	Human	None	skin fibroblast cell lines	O00623;P50542	5193;5830;	MI:0019-coimmunoprecipitation;MI:0018-two hybrid	GO:0016558;GO:0071535	protein import into peroxisome matrix;RING-like zinc finger domain binding	None	None	10562279	Peroxisomal matrix protein import requires PEX12, an integral peroxisomal membrane protein with a zinc ring domain at its carboxy terminus. It was observed that the zinc-binding domain of PEX12 binds both PEX5, the PTS1 receptor, and PEX10, another integral peroxisomal membrane protein required for peroxisomal matrix protein import.	Mutations in human PEX12 result in Zellweger syndrome, a lethal neurological disorder, and implicate the zinc ring domain in PEX12 function. A missense mutation in the PEX12 zinc-binding domain, S320F, reduces the binding of PEX12 to PEX5 and PEX10. Overexpression of either PEX5 or PEX10 can suppress this PEX12 mutation.	None	Homo sapiens (Human);Homo sapiens (Human)	Peroxisome assembly protein 12;Peroxisomal targeting signal 1 receptor	PEX12;PEX5	PAF3;PXR1
8792	PEX10-PEX12 complex	Human	None	skin fibroblast cell lines	O00623;O60683	5193;5192	MI:0019-coimmunoprecipitation;MI:0018-two hybrid	GO:0016558;GO:0071535	protein import into peroxisome matrix;RING-like zinc finger domain binding	None	None	10562279	Peroxisomal matrix protein import requires PEX12, an integral peroxisomal membrane protein with a zinc ring domain at its carboxy terminus. It was observed that the zinc-binding domain of PEX12 binds both PEX5, the PTS1 receptor, and PEX10, another integral peroxisomal membrane protein required for peroxisomal matrix protein import.	Mutations in human PEX12 result in Zellweger syndrome, a lethal neurological disorder, and implicate the zinc ring domain in PEX12 function. A missense mutation in the PEX12 zinc-binding domain, S320F, reduces the binding of PEX12 to PEX5 and PEX10. Overexpression of either PEX5 or PEX10 can suppress this PEX12 mutation.	None	Homo sapiens (Human);Homo sapiens (Human)	Peroxisome assembly protein 12;Peroxisome biogenesis factor 10	PEX12;PEX10	PAF3;RNF69
8796	RAB5IF-TMCO1 complex	Human	C20orf24-TMCO1 complex; OPTI-TMCO1 complex	in vitro	Q9BUV8;Q9UM00	55969;;54499;	MI:0019-coimmunoprecipitation	GO:0061077	chaperone-mediated protein folding	None	None	36261528	According to a model for multipass membrane protein biogenesis, nascent membrane proteins trigger not only PAT complex (CORUM-ID 7781) recruitment but also the NCLN-NOMO1-TMEM147 complex (CORUM-ID 7865) and the RAB5IF-TMCO1 complex.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Respirasome Complex Assembly Factor 1;Calcium load-activated calcium channel	RAB5IF;TMCO1	C20orf24 RCAF1;TMCC4
8802	NOD2-RIPK2 complex	Human	None	SW480 cells; HT29 cells; HCT116 cells	O43353;Q9HC29	8767;64127	MI:0019-coimmunoprecipitation	GO:0045089	positive regulation of innate immune response	None	None	21931826	None	Cigarette smoke extract delayed TNFalpha-induced NOD2 mRNA expression and was associated with abnormal NOD2/RIPK2 interaction, reduced NFkappaB activity and decreased chemokine production. These effects may be involved in the pathogenesis of small-intestinal Crohn's disease.	None	Homo sapiens (Human);Homo sapiens (Human)	Receptor-interacting serine/threonine-protein kinase 2;Nucleotide-binding oligomerization domain-containing protein 2	RIPK2;NOD2	CARDIAK RICK RIP2;CARD15 IBD1
8808	KEAP1-SQSTM1 complex	Human	KEAP1-p62 complex	SKOV3 cells (ovarian adenocarcinoma cells)	Q13501;Q14145	8878;9817	MI:0019-coimmunoprecipitation;MI:0416-fluorescence microscopy	GO:0006954;GO:0045088	inflammatory response;regulation of innate immune response	36.25.16.07	inflammatory response	32047536	The autophagy-adaptor protein SQSTM1 (p62) is assembled on selective autophagic cargos such as ubiquitinated organelles and subsequently phosphorylated in an mTORC1-dependent manner. Phosphorylation of SQSTM1 markedly increases SQSTM1\u2019s binding affinity for Keap1, an adaptor of the Cul3-ubiquitin E3 ligase complex responsible for degrading Nrf2. Thus, SQSTM1 phosphorylation induces expression of cytoprotective Nrf2 targets (24011591).	Results of the study suggest that overexpressed SQSTM1 (p62) may protect cells from oxidative damage caused by vitamin K3 through activating Keap1/Nrf2 signaling in ovarian cancer.	None	Homo sapiens (Human);Homo sapiens (Human)	Sequestosome-1;Kelch-like ECH-associated protein 1	SQSTM1;KEAP1	ORCA OSIL;INRF2 KIAA0132 KLHL19
8811	ACHE-NRXN1 complex	Human	ACHE-NRXN1B complex	HEK293 cells	P22303;P58400	43;;9378	MI:0019-coimmunoprecipitation	GO:0060076;GO:0003990;GO:0035249	excitatory synapse;acetylcholinesterase activity;synaptic transmission, glutamatergic	None	None	24594013	The activity and expression levels of AChE control the amount of extracellular acetylcholine, which critically regulates glutamatergic synaptic transmission. When expressed in human embryonic kidney 293 cells, N-glycosylated AChE co-immunoprecipitated with non-O-glycosylated neurexin-1beta, with N-glycosylation of the AChE being required for this co-precipitation to occur.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Acetylcholinesterase (AChE) (EC 3.1.1.7);Neurexin-1-beta	ACHE;NRXN1	None;
8813	APOA1-BCHE complex	Human	None	human blood serum	P02647;P06276	335;590;	MI:0113-western blot;MI:0091-chromatography technology;MI:0019-coimmunoprecipitation;MI:0096-pull down	GO:0004104	cholinesterase activity	None	None	34639003	Butyrylcholinesterase (BChE), an enzyme existing mainly as a glycosylated soluble tetramer, plays an important role in the metabolism of many drugs. BChE interacts with a number of proteins in the human serum. Some of these interactions seem to be more stable than transient. BChE copurification with ApoA-I and the density of some fractions containing BChE corresponding to high-density lipoprotein cholesterol (HDL) during ultracentrifugation suggest its interactions with HDL. A lower BChE plasma activity was observed in individuals with severely reduced HDL levels. Western blot analysis revealed ApoA-I and ApoB100, which are protein markers of HDL and LDL, respectively.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Apolipoprotein A-I;Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) (Butyrylcholine esterase) (Choline esterase II) (Pseudocholinesterase)	APOA1;BCHE	None;CHE1
8814	APOB-BCHE complex	Human	ApoB100-BCHE complex	human blood serum	P04114;P06276	338;;590;	MI:0019-coimmunoprecipitation;MI:0113-western blot;MI:0091-chromatography technology	GO:0004104	cholinesterase activity	None	None	34639003	Butyrylcholinesterase (BChE), an enzyme existing mainly as a glycosylated soluble tetramer, plays an important role in the metabolism of many drugs. BChE interacts with a number of proteins in the human serum. Some of these interactions seem to be more stable than transient. BChE copurification with ApoA-I and the density of some fractions containing BChE corresponding to high-density lipoprotein cholesterol (HDL) during ultracentrifugation suggest its interactions with HDL. A lower BChE plasma activity was observed in individuals with severely reduced HDL levels. Western blot analysis revealed ApoA-I and ApoB100, which are protein markers of HDL and LDL, respectively.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Apolipoprotein B-100 (Apo B-100) [Cleaved into: Apolipoprotein B-48 (Apo B-48)];Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) (Butyrylcholine esterase) (Choline esterase II) (Pseudocholinesterase)	APOB;BCHE	None;CHE1
8815	BCHE-CLU complex	Human	None	human blood serum	P06276;P10909	590;;1191;	MI:0004-affinity chromatography technology;MI:0096-pull down;MI:0019-coimmunoprecipitation;MI:0069-mass spectrometry studies of complexes	GO:0004104	cholinesterase activity	None	None	34639003	Butyrylcholinesterase (BChE), an enzyme existing mainly as a glycosylated soluble tetramer, plays an important role in the metabolism of many drugs. Binding studies revealed that BChE interacts with a number of proteins in the human serum. Pull-down studies showed that probably all detected keratin and the immune system proteins bind non-specifically, while proteins, i.e., ApoA-I, clusterin, vitronectin, and serum albumin, seem to bind more specifically to BChE protein.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) (Butyrylcholine esterase) (Choline esterase II) (Pseudocholinesterase);Clusterin (Aging-associated gene 4 protein) (Apolipoprotein J) (Apo-J) (Complement cytolysis inhibitor) (CLI) (Complement-associated protein SP-40,40) (Ku70-binding protein 1) (NA1/NA2) (Sulfated glycoprotein 2) (SGP-2) (Testosterone-repressed prostate message 2) (TRPM-2) [Cleaved into: Clusterin beta chain (ApoJalpha) (Complement cytolysis inhibitor a chain); Clusterin alpha chain (ApoJbeta) (Complement cytolysis inhibitor b chain)]	BCHE;CLU	CHE1;APOJ CLI KUB1
8817	BCHE-KRT1 complex	Human	None	human blood serum	P04264;P06276	3848;;590;	MI:0019-coimmunoprecipitation;MI:0096-pull down;MI:0069-mass spectrometry studies of complexes;MI:0113-western blot	GO:0004104	cholinesterase activity	None	None	34639003	Butyrylcholinesterase (BChE), an enzyme existing mainly as a glycosylated soluble tetramer, plays an important role in the metabolism of many drugs. Binding studies revealed that BChE interacts with a number of proteins in the human serum. Pull-down studies showed that probably all detected keratin and the immune system proteins bind non-specifically, while proteins, i.e., ApoA-I, clusterin, vitronectin, and serum albumin, seem to bind more specifically to BChE protein.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Keratin, type II cytoskeletal 1 (67 kDa cytokeratin) (Cytokeratin-1) (CK-1) (Hair alpha protein) (Keratin-1) (K1) (Type-II keratin Kb1);Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) (Butyrylcholine esterase) (Choline esterase II) (Pseudocholinesterase)	KRT1;BCHE	KRTA;CHE1
8818	BCHE-KRT10 complex	Human	None	human blood serum	P06276;P13645	590;;3858;	MI:0019-coimmunoprecipitation;MI:0096-pull down;MI:0069-mass spectrometry studies of complexes;MI:0113-western blot	GO:0004104	cholinesterase activity	None	None	34639003	Butyrylcholinesterase (BChE), an enzyme existing mainly as a glycosylated soluble tetramer, plays an important role in the metabolism of many drugs. Binding studies revealed that BChE interacts with a number of proteins in the human serum. Pull-down studies showed that probably all detected keratin and the immune system proteins bind non-specifically, while proteins, i.e., ApoA-I, clusterin, vitronectin, and serum albumin, seem to bind more specifically to BChE protein.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) (Butyrylcholine esterase) (Choline esterase II) (Pseudocholinesterase);Keratin, type I cytoskeletal 10 (Cytokeratin-10) (CK-10) (Keratin-10) (K10)	BCHE;KRT10	CHE1;KPP
8819	ALB-BCHE complex	Human	None	human blood serum	P02768;P06276	213;;590;	MI:0019-coimmunoprecipitation;MI:0096-pull down;MI:0069-mass spectrometry studies of complexes;MI:0113-western blot	GO:0004104	cholinesterase activity	None	None	34639003	Butyrylcholinesterase (BChE), an enzyme existing mainly as a glycosylated soluble tetramer, plays an important role in the metabolism of many drugs. Binding studies revealed that BChE interacts with a number of proteins in the human serum. Pull-down studies showed that probably all detected keratin and the immune system proteins bind non-specifically, while proteins, i.e., ApoA-I, clusterin, vitronectin, and serum albumin, seem to bind more specifically to BChE protein.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Albumin;Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) (Butyrylcholine esterase) (Choline esterase II) (Pseudocholinesterase)	ALB;BCHE	None;CHE1
8820	BCHE-KRT9 complex	Human	None	human blood serum	P06276;P35527	590;;3857;	MI:0019-coimmunoprecipitation;MI:0096-pull down;MI:0069-mass spectrometry studies of complexes;MI:0113-western blot	GO:0004104	cholinesterase activity	None	None	34639003	Butyrylcholinesterase (BChE), an enzyme existing mainly as a glycosylated soluble tetramer, plays an important role in the metabolism of many drugs. Binding studies revealed that BChE interacts with a number of proteins in the human serum. Pull-down studies showed that probably all detected keratin and the immune system proteins bind non-specifically, while proteins, i.e., ApoA-I, clusterin, vitronectin, and serum albumin, seem to bind more specifically to BChE protein.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) (Butyrylcholine esterase) (Choline esterase II) (Pseudocholinesterase);Keratin, type I cytoskeletal 9 (Cytokeratin-9) (CK-9) (Keratin-9) (K9)	BCHE;KRT9	CHE1;None
8821	BCHE-KRT2 complex	Human	None	human blood serum	P06276;P35908	590;;3849;	MI:0019-coimmunoprecipitation;MI:0096-pull down;MI:0069-mass spectrometry studies of complexes;MI:0113-western blot	GO:0004104	cholinesterase activity	None	None	34639003	Butyrylcholinesterase (BChE), an enzyme existing mainly as a glycosylated soluble tetramer, plays an important role in the metabolism of many drugs. Binding studies revealed that BChE interacts with a number of proteins in the human serum. Pull-down studies showed that probably all detected keratin and the immune system proteins bind non-specifically, while proteins, i.e., ApoA-I, clusterin, vitronectin, and serum albumin, seem to bind more specifically to BChE protein.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) (Butyrylcholine esterase) (Choline esterase II) (Pseudocholinesterase);Keratin, type II cytoskeletal 2 epidermal (Cytokeratin-2e) (CK-2e) (Epithelial keratin-2e) (Keratin-2 epidermis) (Keratin-2e) (K2e) (Type-II keratin Kb2)	BCHE;KRT2	CHE1;KRT2A KRT2E
8822	BCHE-KRT14 complex	Human	None	human blood serum	P02533;P06276	3861;590;	MI:0019-coimmunoprecipitation;MI:0096-pull down;MI:0069-mass spectrometry studies of complexes;MI:0113-western blot	GO:0004104	cholinesterase activity	None	None	34639003	Butyrylcholinesterase (BChE), an enzyme existing mainly as a glycosylated soluble tetramer, plays an important role in the metabolism of many drugs. Binding studies revealed that BChE interacts with a number of proteins in the human serum. Pull-down studies showed that probably all detected keratin and the immune system proteins bind non-specifically, while proteins, i.e., ApoA-I, clusterin, vitronectin, and serum albumin, seem to bind more specifically to BChE protein.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Keratin, type I cytoskeletal 14 ;Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) (Butyrylcholine esterase) (Choline esterase II) (Pseudocholinesterase)	KRT14;BCHE	;CHE1
8823	AHSG-BCHE complex	Human	BCHE-FETUA complex	human blood serum	P02765;P06276	197;590;	MI:0019-coimmunoprecipitation;MI:0096-pull down;MI:0069-mass spectrometry studies of complexes;MI:0113-western blot	GO:0004104	cholinesterase activity	None	None	34639003	Butyrylcholinesterase (BChE), an enzyme existing mainly as a glycosylated soluble tetramer, plays an important role in the metabolism of many drugs. Binding studies revealed that BChE interacts with a number of proteins in the human serum. Pull-down studies showed that probably all detected keratin and the immune system proteins bind non-specifically, while proteins, i.e., ApoA-I, clusterin, vitronectin, and serum albumin, seem to bind more specifically to BChE protein.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Alpha-2-HS-glycoprotein ;Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) (Butyrylcholine esterase) (Choline esterase II) (Pseudocholinesterase)	AHSG;BCHE	FETUA;CHE1
8824	BCHE-KRT6B complex	Human	None	human blood serum	P04259;P06276	3854;;590;	MI:0019-coimmunoprecipitation;MI:0096-pull down;MI:0069-mass spectrometry studies of complexes;MI:0113-western blot	GO:0004104	cholinesterase activity	None	None	34639003	Butyrylcholinesterase (BChE), an enzyme existing mainly as a glycosylated soluble tetramer, plays an important role in the metabolism of many drugs. Binding studies revealed that BChE interacts with a number of proteins in the human serum. Pull-down studies showed that probably all detected keratin and the immune system proteins bind non-specifically, while proteins, i.e., ApoA-I, clusterin, vitronectin, and serum albumin, seem to bind more specifically to BChE protein.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Keratin, type II cytoskeletal 6B (Cytokeratin-6B) (CK-6B) (Keratin-6B) (K6B) (Type-II keratin Kb10);Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) (Butyrylcholine esterase) (Choline esterase II) (Pseudocholinesterase)	KRT6B;BCHE	K6B KRTL1;CHE1
8825	BCHE-TF complex	Human	None	human blood serum	P02787;P06276	7018;590;	MI:0019-coimmunoprecipitation;MI:0096-pull down;MI:0069-mass spectrometry studies of complexes;MI:0113-western blot	GO:0004104	cholinesterase activity	None	None	34639003	Butyrylcholinesterase (BChE), an enzyme existing mainly as a glycosylated soluble tetramer, plays an important role in the metabolism of many drugs. Binding studies revealed that BChE interacts with a number of proteins in the human serum. Pull-down studies showed that probably all detected keratin and the immune system proteins bind non-specifically, while proteins, i.e., ApoA-I, clusterin, vitronectin, and serum albumin, seem to bind more specifically to BChE protein.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Serotransferrin;Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) (Butyrylcholine esterase) (Choline esterase II) (Pseudocholinesterase)	TF;BCHE	None;CHE1
8826	BCHE-KRT6A complex	Human	None	human blood serum	P02538;P06276	3853;;590;	MI:0019-coimmunoprecipitation;MI:0096-pull down;MI:0069-mass spectrometry studies of complexes;MI:0113-western blot	GO:0004104	cholinesterase activity	None	None	34639003	Butyrylcholinesterase (BChE), an enzyme existing mainly as a glycosylated soluble tetramer, plays an important role in the metabolism of many drugs. Binding studies revealed that BChE interacts with a number of proteins in the human serum. Pull-down studies showed that probably all detected keratin and the immune system proteins bind non-specifically, while proteins, i.e., ApoA-I, clusterin, vitronectin, and serum albumin, seem to bind more specifically to BChE protein.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Keratin, type II cytoskeletal 6A (Cytokeratin-6A) (CK-6A) (Cytokeratin-6D) (CK-6D) (Keratin-6A) (K6A) (Type-II keratin Kb6) (allergen Hom s 5);Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) (Butyrylcholine esterase) (Choline esterase II) (Pseudocholinesterase)	KRT6A;BCHE	K6A KRT6D;CHE1
8827	BCHE-KRT5 complex	Human	None	human blood serum	P06276;P13647	590;;3852	MI:0019-coimmunoprecipitation;MI:0096-pull down;MI:0069-mass spectrometry studies of complexes;MI:0113-western blot	GO:0004104	cholinesterase activity	None	None	34639003	Butyrylcholinesterase (BChE), an enzyme existing mainly as a glycosylated soluble tetramer, plays an important role in the metabolism of many drugs. Binding studies revealed that BChE interacts with a number of proteins in the human serum. Pull-down studies showed that probably all detected keratin and the immune system proteins bind non-specifically, while proteins, i.e., ApoA-I, clusterin, vitronectin, and serum albumin, seem to bind more specifically to BChE protein.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) (Butyrylcholine esterase) (Choline esterase II) (Pseudocholinesterase);Keratin, type II cytoskeletal 5	BCHE;KRT5	CHE1;
8828	BCHE-C1S complex	Human	None	human blood serum	P06276;P09871	590;;716;	MI:0019-coimmunoprecipitation;MI:0096-pull down;MI:0069-mass spectrometry studies of complexes;MI:0113-western blot	GO:0004104	cholinesterase activity	None	None	34639003	Butyrylcholinesterase (BChE), an enzyme existing mainly as a glycosylated soluble tetramer, plays an important role in the metabolism of many drugs. Binding studies revealed that BChE interacts with a number of proteins in the human serum. Pull-down studies showed that probably all detected keratin and the immune system proteins bind non-specifically, while proteins, i.e., ApoA-I, clusterin, vitronectin, and serum albumin, seem to bind more specifically to BChE protein.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) (Butyrylcholine esterase) (Choline esterase II) (Pseudocholinesterase);Complement C1s subcomponent (EC 3.4.21.42) (C1 esterase) (Complement component 1 subcomponent s) [Cleaved into: Complement C1s subcomponent heavy chain; Complement C1s subcomponent light chain]	BCHE;C1S	CHE1;None
8829	BCHE-KRT16 complex	Human	None	human blood serum	P06276;P08779	590;;3868;	MI:0019-coimmunoprecipitation;MI:0096-pull down;MI:0069-mass spectrometry studies of complexes;MI:0113-western blot	GO:0004104	cholinesterase activity	None	None	34639003	Butyrylcholinesterase (BChE), an enzyme existing mainly as a glycosylated soluble tetramer, plays an important role in the metabolism of many drugs. Binding studies revealed that BChE interacts with a number of proteins in the human serum. Pull-down studies showed that probably all detected keratin and the immune system proteins bind non-specifically, while proteins, i.e., ApoA-I, clusterin, vitronectin, and serum albumin, seem to bind more specifically to BChE protein.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) (Butyrylcholine esterase) (Choline esterase II) (Pseudocholinesterase);Keratin, type I cytoskeletal 16 (Cytokeratin-16) (CK-16) (Keratin-16) (K16)	BCHE;KRT16	CHE1;KRT16A
8830	BCHE-IGHG1 complex	Human	None	human blood serum	P06276;P0DOX5	590;;None	MI:0019-coimmunoprecipitation;MI:0096-pull down;MI:0069-mass spectrometry studies of complexes;MI:0113-western blot	GO:0004104	cholinesterase activity	None	None	34639003	Butyrylcholinesterase (BChE), an enzyme existing mainly as a glycosylated soluble tetramer, plays an important role in the metabolism of many drugs. Binding studies revealed that BChE interacts with a number of proteins in the human serum. Pull-down studies showed that probably all detected keratin and the immune system proteins bind non-specifically, while proteins, i.e., ApoA-I, clusterin, vitronectin, and serum albumin, seem to bind more specifically to BChE protein.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) (Butyrylcholine esterase) (Choline esterase II) (Pseudocholinesterase);Immunoglobulin gamma-1 heavy chain (Immunoglobulin gamma-1 heavy chain NIE)	BCHE;None	CHE1;None
8831	BCHE-VTN complex	Human	None	human blood serum	P04004;P06276	7448;590;	MI:0019-coimmunoprecipitation;MI:0096-pull down;MI:0069-mass spectrometry studies of complexes;MI:0113-western blot	GO:0004104	cholinesterase activity	None	None	34639003	Butyrylcholinesterase (BChE), an enzyme existing mainly as a glycosylated soluble tetramer, plays an important role in the metabolism of many drugs. Binding studies revealed that BChE interacts with a number of proteins in the human serum. Pull-down studies showed that probably all detected keratin and the immune system proteins bind non-specifically, while proteins, i.e., ApoA-I, clusterin, vitronectin, and serum albumin, seem to bind more specifically to BChE protein.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Vitronectin;Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) (Butyrylcholine esterase) (Choline esterase II) (Pseudocholinesterase)	VTN;BCHE	None;CHE1
8832	BCHE-HBB complex	Human	None	human blood serum	P06276;P68871	590;;3043;	MI:0019-coimmunoprecipitation;MI:0096-pull down;MI:0069-mass spectrometry studies of complexes;MI:0113-western blot	GO:0004104	cholinesterase activity	None	None	34639003	Butyrylcholinesterase (BChE), an enzyme existing mainly as a glycosylated soluble tetramer, plays an important role in the metabolism of many drugs. Binding studies revealed that BChE interacts with a number of proteins in the human serum. Pull-down studies showed that probably all detected keratin and the immune system proteins bind non-specifically, while proteins, i.e., ApoA-I, clusterin, vitronectin, and serum albumin, seem to bind more specifically to BChE protein.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) (Butyrylcholine esterase) (Choline esterase II) (Pseudocholinesterase);Hemoglobin subunit beta (Beta-globin) (Hemoglobin beta chain) [Cleaved into: LVV-hemorphin-7; Spinorphin]	BCHE;HBB	CHE1;None
8833	BCHE-THBS1 complex	Human	None	human blood serum	P06276;P07996	590;;7057	MI:0004-affinity chromatography technology;MI:0069-mass spectrometry studies of complexes	GO:0004104	cholinesterase activity	None	None	34639003	Butyrylcholinesterase (BChE), an enzyme existing mainly as a glycosylated soluble tetramer, plays an important role in the metabolism of many drugs. BChE interacts with a number of proteins in the human serum.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) (Butyrylcholine esterase) (Choline esterase II) (Pseudocholinesterase);Thrombospondin-1	BCHE;THBS1	CHE1;TSP TSP1
8835	BCHE-IGHM complex	Human	None	human blood serum	P01871;P06276	3507;590;	MI:0004-affinity chromatography technology;MI:0069-mass spectrometry studies of complexes	GO:0004104	cholinesterase activity	None	None	34639003	Butyrylcholinesterase (BChE), an enzyme existing mainly as a glycosylated soluble tetramer, plays an important role in the metabolism of many drugs. BChE interacts with a number of proteins in the human serum.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Immunoglobulin heavy constant mu;Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) (Butyrylcholine esterase) (Choline esterase II) (Pseudocholinesterase)	IGHM;BCHE	None;CHE1
8836	BCHE-LGALS3BP complex	Human	None	human blood serum	P06276;Q08380	590;;3959;	MI:0004-affinity chromatography technology;MI:0069-mass spectrometry studies of complexes	GO:0004104	cholinesterase activity	None	None	34639003	Butyrylcholinesterase (BChE), an enzyme existing mainly as a glycosylated soluble tetramer, plays an important role in the metabolism of many drugs. BChE interacts with a number of proteins in the human serum.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) (Butyrylcholine esterase) (Choline esterase II) (Pseudocholinesterase);Galectin-3-binding protein (Basement membrane autoantigen p105) (Lectin galactoside-binding soluble 3-binding protein) (Mac-2-binding protein) (MAC2BP) (Mac-2 BP) (Tumor-associated antigen 90K)	BCHE;LGALS3BP	CHE1;M2BP
8837	A2M-BCHE complex	Human	None	human blood serum	P01023;P06276	2;590;	MI:0004-affinity chromatography technology;MI:0069-mass spectrometry studies of complexes	GO:0004104	cholinesterase activity	None	None	34639003	Butyrylcholinesterase (BChE), an enzyme existing mainly as a glycosylated soluble tetramer, plays an important role in the metabolism of many drugs. BChE interacts with a number of proteins in the human serum.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Alpha-2-macroglobulin;Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) (Butyrylcholine esterase) (Choline esterase II) (Pseudocholinesterase)	A2M;BCHE	CPAMD5;CHE1
8838	BCHE-HPR complex	Human	None	human blood serum	P00739;P06276	3250;590;	MI:0004-affinity chromatography technology;MI:0069-mass spectrometry studies of complexes	GO:0004104	cholinesterase activity	None	None	34639003	Butyrylcholinesterase (BChE), an enzyme existing mainly as a glycosylated soluble tetramer, plays an important role in the metabolism of many drugs. BChE interacts with a number of proteins in the human serum.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Haptoglobin-related protein;Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) (Butyrylcholine esterase) (Choline esterase II) (Pseudocholinesterase)	HPR;BCHE	None;CHE1
8839	BCHE-HP complex	Human	None	human blood serum	P00738;P06276	3240;590;	MI:0004-affinity chromatography technology;MI:0069-mass spectrometry studies of complexes	GO:0004104	cholinesterase activity	None	None	34639003	Butyrylcholinesterase (BChE), an enzyme existing mainly as a glycosylated soluble tetramer, plays an important role in the metabolism of many drugs. BChE interacts with a number of proteins in the human serum.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Haptoglobin ;Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) (Butyrylcholine esterase) (Choline esterase II) (Pseudocholinesterase)	HP;BCHE	;CHE1
8840	BCHE homotetramer	Human	None	human blood plasma	P06276	590;	MI:0040-electron microscopy;MI:0826-x ray scattering	GO:0004104;GO:0051262	cholinesterase activity;protein tetramerization	None	None	30385318	Butyrylcholinesterase (EC. 3.1.1.8; BChE) is of toxicological and pharmacological importance, as it hydrolyzes numerous medicamentous and poisonous esters. In addition, it is a stoichiometric bioscavenger of toxic organophosphates It is also considered a therapeutic target against Alzheimer's disease.	None	The tetramer organization of BChE is unique in that the four subunits are joined at their C-termini through noncovalent contacts with a short polyproline-rich peptide.	Homo sapiens (Human)	Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) (Butyrylcholine esterase) (Choline esterase II) (Pseudocholinesterase)	BCHE	CHE1
8841	ACHE homotetramer	Human	ACHE (G4)	human brain (caudate nucleus)	P22303	43;	MI:0807-comigration in gel electrophoresis;MI:0113-western blot;MI:0833-autoradiography	GO:0003990;GO:0051262	acetylcholinesterase activity;protein tetramerization	None	None	3585324	Acetylcholinesterase (AChE; EC 3.1.1.7) has been identified in different tissues of a variety of vertebrate and invertebrate species, and has been shown to occur in multiple molecular forms. Globular forms of AChE occur e.g. in cells involved in cholinergic neurotransmission, but are also found in a variety of other neuronal and some non-neuronal cells as well. The globular forms of AChE may be subdivided into two groups, namely soluble and detergent-soluble AChE.	None	None	Homo sapiens (Human)	Acetylcholinesterase (AChE) (EC 3.1.1.7)	ACHE	None
8842	AHR-ARNT complex	Human	None	in vitro	P27540;P35869	405;196	MI:0412-electrophoretic mobility supershift assay	GO:0006355;GO:0005634	regulation of DNA-templated transcription;nucleus	11.02.03.04;70.10	transcriptional control;nucleus	7929368	Upon activation by ligand binding, AHR enters the nucleus where it interacts with ARNT, forming the liganded AHR-ARNT complex, which binds to specific DNA sequences called xenobiotic response elements (PMID: 10619402).	None	None	Homo sapiens (Human);Homo sapiens (Human)	Aryl hydrocarbon receptor nuclear translocator;Aryl hydrocarbon receptor	ARNT;AHR	BHLHE2;BHLHE76
8843	KDM6A-RNF114 complex	Human	UTX-RNF114 complex	HEK293T cells	O15550;Q9Y508	7403;55905;	MI:0006-anti bait coimmunoprecipitation	GO:0032436;GO:0016567	positive regulation of proteasomal ubiquitin-dependent protein catabolic process;protein ubiquitination	14.07.05	modification by ubiquitination, deubiquitination	35788583	The histone H3K27 demethylase KDM6A (UTX) binds to the E3 ligase RNF114 to ubiquitinate phosphoglycerate dehydrogenase (PHGDH), the rate limiting enzyme for de novo serine synthesis. Ubiquitination induces the proteasomal degradation of  PHGDH and thus suppresses circulating serine levels. (PMID:35788583)	None	None	Homo sapiens (Human);Homo sapiens (Human)	Lysine-specific demethylase 6A;E3 ubiquitin-protein ligase RNF114 (EC 2.3.2.27) (RING finger protein 114) (RING-type E3 ubiquitin transferase RNF114) (Zinc finger protein 228) (Zinc finger protein 313)	KDM6A;RNF114	UTX;ZNF228 ZNF313
8844	COLQ-HSPG2 complex	Human	COLQ-Perlecan complex	HEK293 cells	P98160;Q9Y215	3339;8292;	MI:0019-coimmunoprecipitation;MI:0113-western blot	GO:0031594;GO:0005604	neuromuscular junction;basement membrane	None	None	24281389	The interaction of ColQ to perlecan and MuSK is crucial for anchoring AChE to the neuromuscular junction.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Basement membrane-specific heparan sulfate proteoglycan core protein ;Acetylcholinesterase collagenic tail peptide (AChE Q subunit) (Acetylcholinesterase-associated collagen)	HSPG2;COLQ	;None
8845	COLQ-MUSK complex	Human	None	HEK293 cells	O15146;Q9Y215	4593;;8292;	MI:0019-coimmunoprecipitation;MI:0113-western blot	GO:0005604;GO:0031594	basement membrane;neuromuscular junction	None	None	24281389	The interaction of ColQ to perlecan and MuSK is crucial for anchoring AChE to the neuromuscular junction.	None	None	Homo sapiens (Human);Homo sapiens (Human)	Muscle, skeletal receptor tyrosine-protein kinase (EC 2.7.10.1) (Muscle-specific tyrosine-protein kinase receptor) (MuSK) (Muscle-specific kinase receptor);Acetylcholinesterase collagenic tail peptide (AChE Q subunit) (Acetylcholinesterase-associated collagen)	MUSK;COLQ	None;None
